Neoadjuvant TherapyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: Does the pattern of recurrence differ for patients with complete response and those with partial or no response?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Most esophageal cancer recurrences after neoadjuvant therapy and surgery are distant, and survival time after recurrence is short regardless of pathologic response. Fewer patients achieving complete response had recurrences, and distant recurrences in these patients manifest later than in patients showing partial response and those showing no response. Only pathologic response is significantly associated with disease recurrence, suggesting that tumor biology and chemosensitivity are critical in long-term patient outcome. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - November 20, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Robert A. Meguid, Craig M. Hooker, Joshua T. Taylor, Laurence R. Kleinberg, Stephen M. Cattaneo, Marc S. Sussman, Stephen C. Yang, Richard F. Heitmiller, Arlene A. Forastiere, Malcolm V. Brock Tags: General Thoracic Surgery Source Type: journals

Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment StrategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. From our data, postirradiation sarcoma should not be managed differently from primary sarcoma. Chemotherapy has to be included in the treatment plan of postirradiation sarcoma, in future studies. (Source: Sarcoma)
Source: Sarcoma - November 17, 2009 Category: Cancer & Oncology Source Type: journals

MRI Versus Ultrasonography And Mammography For Preoperative Assessment Of Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Accurate assessment of primary tumor size is an essential part of management in breast cancer patients. Tumor size is part of the TNM system used to stage breast cancer and provide prognostic information. Adaptation of the principles of breast conservation surgery requires evaluation of tumor size to judge appropriateness and extent of surgery. Precise measurement of tumor size is also important to monitor response to neoadjuvant chemotherapy for locally advanced tumors. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Researchers From University Of Utah Discuss Findings In Esophageal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with locally advanced esophageal cancer who require neoadjuvant therapy have significant dysphagia. To prospectively evaluate Polyflex stents to treat malignant dysphagia and to ameliorate weight loss in patients with locally advanced esophageal cancer who will undergo neoadjuvant therapy, scientists in the United States report. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Randomized Clinical Trials in Gastric CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Minimally invasive resection has emerged as a surgical technique for gastric cancer, and there has been continued investigation to determine the appropriate extent of lymphadenectomy in gastric cancer patients. There has also been significant progress in evaluating the role of chemotherapeutic regimens used in the neoadjuvant and adjuvant settings for patients with resectable disease. We also summarize a selection of RCT trials focused on the perioperative care of the gastric cancer patient. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: James J. Mezhir, Venu G. Pillarisetty, Manish A. Shah, Daniel G. Coit Source Type: journals

An Update on Randomized Clinical Trials in Advanced and Metastatic Colorectal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the past eight years, there have been significant advances in the treatment and outcome of patients with metastatic colorectal cancer. This is likely the result of improved imaging, staging, chemotherapy, and surgery. After conducting a standardized MEDLINE literature search, this article reviews the prospective randomized controlled trials in advanced colorectal cancer published between May 2001 and October 2008. There are a total of 96 studies, all chemotherapy-related trials, divided into five categories based on trial focus: (1) types of chemotherapy; (2) administration of adjuvant or neoadjuvant chemotherapy fo...
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Shishir K. Maithel, Michael I. D'Angelica Source Type: journals

Randomized Clinical Trials in Esophageal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The treatment of esophageal cancer with curative intent remains highly controversial, with advocates of surgery alone, chemoradiotherapy alone, surgery with adjuvant therapy (including neoadjuvant and postoperative), and trimodality therapy each contributing prospective randomized controlled trials (PRCTs) to the body of scientific publications between 2000 and 2008. Any improvements in survival have been small in absolute percentage terms, and as such PRCTs published over the last decade have met the same primary obstacle encountered by the studies from the two prior decades, namely lack of power to detect small differenc...
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Stephen A. Barnett, Nabil P. Rizk Source Type: journals

Neoadjuvant chemoradiation and pancreaticoduodenectomy for initially locally advanced head pancreatic adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PD after CRT was safe and resected patients had interesting survival rates. However, resected patients developed metastatic disease and new neoadjuvant regimens are needed to improve the survival of these patients. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: O. Turrini, F. Viret, L. Moureau-Zabotto, J. Guiramand, V. Moutardier, B. Lelong, M. Giovannini, J.R. Delpero Tags: Original Articles Source Type: journals

Influence of neoadjuvant radio-chemotherapy on tumor-infiltrating lymphocytes in squamous esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Neoadjuvant RCT reduced the number of TILs in esophageal SCC. This was primarily seen in the centre of tumors and suggests that the effect of RCT on immunological response is located in the centre of tumors. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: U. Zingg, M. Montani, D.M. Frey, S. Dirnhofer, P. Went, D. Oertli Tags: Original Articles Source Type: journals

Pneumonectomy After Neoadjuvant Chemotherapy and Radiation for Advanced-Stage Lung CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Using a multidisciplinary team approach at a tertiary care center, pneumonectomy can be performed successfully after neoadjuvant chemotherapy and radiation for advanced-stage lung cancer. Vascularized flap for bronchial stump coverage may be important in this regard. Content Type Journal ArticleCategory Thoracic OncologyDOI 10.1245/s10434-009-0810-0Authors Thomas Ng, The Warren Alpert Medical School of Brown University Brown University Oncology Group Providence RI USAAriel E. Birnbaum, The Warren Alpert Medical School of Brown University Brown University Oncology Group Providence RI USAJac...
Source: Annals of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Systematic review of neoadjuvant transarterial chemoembolization for resectable hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resection of hepatocellular carcinoma (HCC) offers the only hope for cure. However, in patients undergoing resection, recurrences, in particular, intrahepatic recurrence are common. The effectiveness of transarterial chemoembolization (TACE) as a neoadjuvant therapy for unresectable HCC was exploited by numerous liver units and employed preoperatively in the setting of resectable HCC with an aim to prevent recurrence and prolong survival. A systematic literature search of databases (Medline and PubMed) to identify published studies of TACE administered preoperatively as a neoadjuvant treatment for resectable HCC was undert...
Source: Liver International - November 14, 2009 Category: Gastroenterology Authors: Terence C. Chua, Winston Liauw, Akshat Saxena, Francis Chu, Derek Glenn, Alan Chai, David L. Morris Source Type: journals

Revisiting the prognostic value of preoperative 18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography (PET) in early-stage (I & II) non-small cell lung cancers (NSCLC)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Each doubling of SUVmax as determined by preoperative PET is associated with a 1.28-fold increase in hazard of death in early-stage (I & II) NSCLC. Preoperative SUVmax is not an independent predictor of overall survival. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1291-xAuthors Mohit Agarwal, Oakland University William Beaumont School of Medicine Hospital Department of Internal Medicine 3601 W 13 Mile Rd Royal Oak MI 48073-6769 USAGovinda Brahmanday, Oakland University William Beaumont School of Medicine Hospital Department of Internal Medicine 3601 W 13 Mile ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 13, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Use and comprehension of complementary and alternative medicine in breast cancer patients: Results from cognitive interviewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Regarding the integration of CAM and conventional medicine many patients wish for and implement themselves, their comprehension of CAM modalities and modes of action plays an important role. Being aware of this is crucial in order to ensure a patient-centred treatment. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: E. Tautz, A. Hasenburg, F. Momm, C. Güthlin Source Type: journals

High preoperative serum vascular endothelial growth factor levels predict poor clinical outcome after curative resection of gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumour vascular endothelial growth factor (VEGF) and tumour urokinase-type plasminogen activator (uPA) are prognostic factors in gastric cancer but surgical specimens are required for testing. The prognostic value of preoperative serum VEGF (s-VEGF) and serum uPA (s-uPA) levels was evaluated in patients undergoing potentially curative (R0) gastric cancer resection.Concentrations of s-VEGF and s-uPA were measured 97 patients with gastric cancer and 20 controls. Angiogenesis was measured in vitro based on human endothelial cell tube formation.Levels of s-VEGF were higher in patients with gastric cancer than controls (median ...
Source: British Journal of Surgery - November 13, 2009 Category: Surgery Authors: Ó. Vidal, J.-P. Metges, I. Elizalde, M. Valentíni, A. Volant, R. Molina, A. Castells, M. Pera Tags: Original Articles Source Type: journals

Prognostic factors for and outcome of locally advanced prostate cancer after radical prostatectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To present the outcomes of cT3N0M0 prostate cancer after radical prostatectomy (RP) and determine the prognostic factors in biochemical progression-free survival (BPFS), clinical progression-free survival (CPFS), cancer-specific survival (CSS) and overall survival (OS) after long-term follow-up of 10 years. In all, 164 patients who were assessed as clinical T3 prostate cancer by digital rectal examination (DRE), underwent RP and bilateral pelvic lymphadenectomy at Erasmus MC between 1977 and 2004 without neoadjuvant treatment. Preoperative staging computed tomography showed no signs of metastasis. Kaplan[ndash]Meier curves...
Source: BJU International - November 13, 2009 Category: Urology & Nephrology Authors: Chao-Yu Hsu, Mark F. Wildhagen, Hein Van Poppel, Chris H. Bangma Source Type: journals

High preoperative serum vascular endothelial growth factor levels predict poor clinical outcome after curative resection of gastric cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION:: High preoperative s-VEGF level is an independent prognostic factor for recurrence and survival after R0 resection of gastric cancer. This may provide a useful guide to decision making regarding neoadjuvant and adjuvant therapies. Copyright (c) 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 19918848 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - November 13, 2009 Category: Surgery Authors: Vidal O, Metges JP, Elizalde I, Valentíni M, Volant A, Molina R, Castells A, Pera M Tags: Br J Surg Source Type: journals

Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we sought to examine the prognostic relevance of ALDH1, a putative cancer stem cell marker, by immunohistochemistry. The four cohorts analyzed included an adjuvantly treated series of 245 invasive cancers, a neoadjuvantly treated series of 34 cases, and two series of 58 and 40 triple negative cases, respectively. Both tumor cell and stromal expression for ALDH1 was evaluated, where possible. Tumor cell ALDH1 expression significantly correlated only with basal-like and HER2 tumor types in the adjuvant series and tumor grade in the neoadjuvant cohort. No significant enrichment for ALDH1 positive cells was...
Source: Breast Cancer Research and Treatment - November 12, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

Anterior Minithoracotomy: A Direct Approach to the Difficult Hilum for Upper Lobectomy, Pneumonectomy, and Sleeve LobectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The Chamberlain mini anterior thoracotomy provides direct access to the pulmonary hilum, facilitating dissection and vascular control for large and central tumors. Reduced perioperative pain and down-lung syndrome compared to lateral approaches can be achieved. Muscle function is preserved, and intrapericardial/hilar access is expeditious. This approach enhances hilar access and avoids the vascular control and hilar exposure challenges inherent with lateral thoracotomy. Content Type Journal ArticleCategory Thoracic OncologyDOI 10.1245/s10434-009-0799-4Authors Brian L. Pettiford, Universit...
Source: Annals of Surgical Oncology - November 12, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Relapse in resected lung cancer revisited: does intensified follow up really matter? A prospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: the intensified follow up did not increase either the proportion of patients detected with asymptomatic relapse or the number of patients with specific oncological treatment of relapse. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - November 12, 2009 Category: Cancer & Oncology Authors: Dragan SuboticDragan MandaricGordana RadosavljevicJelena StojsicMilan GajicMaja Ercegovac Source Type: journals

The Christie Experience of Neoadjuvant Chemotherapy for Invasive Bladder Cancer. Tolerance, Short Term Response and Time to Definitive TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: Neoadjuvant chemotherapy in muscle-invasive bladder cancer has demonstrated a 5% improvement in absolute overall survival (OS) at 5 years. This retrospective study addressed the tolerance and response to this approach. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: B. Jyoti, C. Chan, D. Corgie, A. Choudhury, J. Wylie Tags: Abstracts Source Type: journals

Antagonistic interaction between bicalutamideTM (Casodex®) and radiation in androgen-positive prostate cancer LNCaP cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BicalutamideTM (Casodex®) reportedly improves high-risk prostate cancer survival as an adjuvant treatment following radiotherapy. However, biological data for the interaction between bicalutamide and ionizing radiation in concomitant association are lacking.To explore this issue, androgen-dependent (LNCaP) and -independent (DU145) human prostate cancer cells were exposed for 48 hr to 20, 40, or 80 µM bicalutamide introduced before (neoadjuvant), during (concomitant), or following (adjuvant) radiation. Growth inhibition and cytotoxicity, cell cycle distribution and expression of the prostate serum antigen (PSA) and androg...
Source: The Prostate - November 9, 2009 Category: Urology & Nephrology Authors: Laurent Quéro, Nicole Giocanti, Christophe Hennequin, Vincent Favaudon Source Type: journals

EUS diagnosis of a primary pancreatic metastasis of alveolar rhabdomyosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: To our knowledge this is the first reported case of EUS guided FNA diagnosis of alveolar rhabdomyosarcoma metastatic to the pancreas. This is also the only case report of a primary pancreatic metastasis of this type of tumor in a male patient (which occurs less commonly than in females). PMID: 19890194 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Vanwoerkom RC, Bentz J, Chen L, Adler DG Tags: JOP Source Type: journals

Some reflexions on the modified Appleby procedure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: CT vascular encasement is not always synonymous with real tumoral vascular invasion. Improvement in the quality of anesthesiological and surgical techniques has allowed vascular resections with lower morbidity. A cholecystectomy should always be performed using the modified Appleby procedure. PMID: 19890192 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Morera-Ocon FJ, Cárcel-Cárcel I, Ballestín Vicente J, Iranzo González-Cruz V Tags: JOP Source Type: journals

Surgical Management of Colorectal Liver MetastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinics in Colon and Rectal Surgery 2009; 22: 225-232DOI: 10.1055/s-0029-1242462ABSTRACTColorectal cancer is the third most commonly diagnosed cancer with approximately half of the patients developing liver metastases during the course of their disease. Modern multimodal therapies have improved the overall survival. Liver resection remains the most important modality in the treatment of colorectal liver metastases. The evolution of the criteria for resectability has resulted in more patients being offered a hepatectomy. This is further augmented with the utilization of adjuncts to liver resection, including portal vein emb...
Source: Clinics in Colon and Rectal Surgery - November 7, 2009 Category: Surgery Source Type: journals

Association of age and response to androgen-deprivation therapy with or without radiotherapy for prostate cancer: data from CaPSUREEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess whether the response to primary androgen-deprivation therapy (PADT) and radiotherapy (RT) plus adjuvant ADT would be muted in older men, as their tumours might already be relatively androgen insensitive, because serum testosterone levels decline with increasing age. Using the Cancer of the Prostate Strategic Urologic Research Endeavor database, we conducted an observational study evaluating two groups of men treated for prostate cancer from 1995 to 2006. One group of 1748 men was treated with PADT and the second group of 612 men was treated with RT (external beam RT or brachytherapy) with neoadjuvant and/or adjuv...
Source: BJU International - November 4, 2009 Category: Urology & Nephrology Authors: David Aaronson, Janet Cowan, Peter Carroll, Badrinath Konety Source Type: journals

Neoadjuvant chemotherapy with a combination of docetaxel, cisplatin, fluorouracil, and leucovorin in nonresectable advanced gastric cancer: a short communicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study was to evaluate the efficacy and toxicity of docetaxel (TAX), cisplatin (CDDP), and fluorouracil (5-FU) plus leucovorin (CF) as the neoadjuvant chemotherapy (NACT) regimens in the treatment of nonresectable advanced gastric cancer. Twelve patients with nonresectable advanced gastric cancer were treated with NACT regimens consisted of docetaxel, cisplatin, fluorouracil, plus leucovorin before operation. Nine of the 12 patients were downstaged and 8 were radically operated after the end of the NACT. The overall response rate was 75% with 8.3% complete response and 66.7% partial r...
Source: Medical Oncology - November 3, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Noninvasive Imaging Surrogate of Angiogenesis in OsteosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests an important role of DCE-MRI as a noninvasive imaging surrogate of tumor angiogenesis in osteosarcoma based on visual inspection of TIC. Pediatr Blood Cancer. © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Jyoti Bajpai, Shivanand Gamanagatti, Mehar C. Sharma, Rakesh Kumar, Sreenivas Vishnubhatla, Shah Alam Khan, Shishir Rastogi, Arun Malhotra, Sameer Bakhshi Source Type: journals

Editorial CommentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with invasive upper tract transitional cell carcinoma (UTTCC) pose a difficult management problem with prognosis dependent on the degree of invasion, the relationship, if any, to previous superficial or invasive bladder cancer, and the presence of metastatic nodes. Similar to invasive bladder cancer, preoperative staging can often be inaccurate and distinguishing superficial invasion from deep invasion may not always be possible. Unlike invasive bladder cancer, strategies to improve survival rates using neoadjuvant systemic chemotherapy before nephroureterectomy have not been subjected to clinical trials. However,...
Source: Urology - November 1, 2009 Category: Urology & Nephrology Authors: Paul Russo Tags: Oncology Source Type: journals

Interferon-gamma 874A>T genetic polymorphism is associated with infectious complications following surgery in patients with thoracic esophageal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings suggest that the IFN-gamma 874A>T polymorphism is potentially predictive of the likelihood that patients undergoing esophagectomy for thoracic esophageal cancer will develop postoperative infections. This polymorphism may therefore have important clinical relevance and should be considered when treatment regimens are designed. PMID: 19733878 [PubMed - indexed for MEDLINE] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - November 1, 2009 Category: Information Technology Authors: Motoyama S, Miura M, Hinai Y, Maruyama K, Usami S, Nakatsu T, Saito H, Minamiya Y, Murata K, Suzuki T, Ogawa J Tags: Surgery Source Type: journals

Modified neoadjuvant short-course radiation therapy in uT3 rectal carcinoma: low local recurrence rate with unchanged overall survival and frequent morbidityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Compared to the literature-modified 8 × 3 Gy neoadjuvant SCRT and surgery in uT3, rectal carcinoma was associated with low local recurrence but frequent peri-operative complications. The decisive prognostic factor, distant metastasis, was unaffected. Difficulties included overestimation of tumour invasion depth by endosonography. Possible clinical consequences of the results are discussed. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0823-yAuthors Rainer Kube, An-Institut für Qualitätssicherung in der operativen Medizin (gGmbH) an der Otto-von-Gu...
Source: International Journal of Colorectal Disease - October 30, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals

Does the sequence of taxane administration affect the outcome of patients with breast cancer in the adjuvant and neoadjuvant settings?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-009-9322-9Authors Ali Alkan, Hacettepe University School of Medicine Department of Internal Medicine Ankara TurkeyUgur Sahin, Hacettepe University School of Medicine Department of Internal Medicine Ankara TurkeyKadri Altundag, Hacettepe University Institute of Oncology Department of Medical Oncology 06100 Sihhiye, Ankara Turkey Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology)
Source: Medical Oncology - October 30, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

[Analysis of postoperative morbidity in patients with gastric adenocarcinoma treated using a protocol of preoperative chemoradiotherapy and surgery.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Preoperative treatment with chemoradiotherapy in patients with locally advanced stomach cancer does not increase the incidence of post-surgical complication. The preoperative condition of the patient (BMI) and extending the surgery to the spleen and pancreas are prognostic factors of early postoperative complications. PMID: 19880100 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - October 30, 2009 Category: Surgery Authors: Valentí V, Hernández-Lizoain JL, Martínez Regueira F, Gil A, Martí P, Zozaya G, Bueno A, Pedano N, Arredondo J, Beorlegui MC, Alvarez-Cienfuegos J Tags: Cir Esp Source Type: journals

Preoperative Multimodality Therapy Improves Disease-Free Survival in Patients With Carcinoma of the Rectum: NSABP R-03 [Gastrointestinal Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Preoperative chemoradiotherapy, compared with postoperative chemoradiotherapy, significantly improved DFS and showed a trend toward improved OS. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Roh, Colangelo, O'Connell, Yothers, Deutsch, Allegra, Kahlenberg, Baez-Diaz, Ursiny, Petrelli, Wolmark Tags: Chemotherapy Gastrointestinal Cancer Source Type: journals

Diagnostic performance of fluorodeoxyglucose-positron emission tomography/computed tomography of breast cancer in detecting axillary lymph node metastasis: comparison with ultrasonography and contrast-enhanced CTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PET/CT showed poor sensitivity and high specificity in the detection of axillary lymph node metastasis of breast cancer. Diagnostic performance of PET/CT was not superior to that of ultrasonography and contrast-enhanced CT. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-009-0314-9Authors Shuichi Monzawa, Hyogo Cancer Center Department of Radiology Kitaohji 13-70 Akashi Hyogo 673-8558 JapanShuji Adachi, Hyogo Cancer Center Department of Radiology Kitaohji 13-70 Akashi Hyogo 673-8558 JapanKayo Suzuki, Hyogo Cancer Center Department of Radiology Kitaohji 13-70 Akashi H...
Source: Annals of Nuclear Medicine - October 29, 2009 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals

Widespread Estrogen-Dependent Repression of microRNAs Involved in Breast Tumor Cell GrowthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Altered expression of microRNAs (miRNA), an abundant class of small nonprotein-coding RNAs that mostly function as negative regulators of protein-coding gene expression, is common in cancer. Here, we analyze the regulation of miRNA expression in response to estrogen, a steroid hormone that is involved in the development and progression of breast carcinomas and that is acting via the estrogen receptors (ER) transcription factors. We set out to thoroughly describe miRNA expression, by using miRNA microarrays and real-time reverse transcription-PCR (RT-PCR) experiments, in various breast tumor cell lines in which estrogen sig...
Source: Cancer Research - October 29, 2009 Category: Cancer & Oncology Authors: Maillot, G., Lacroix-Triki, M., Pierredon, S., Gratadou, L., Schmidt, S., Benes, V., Roche, H., Dalenc, F., Auboeuf, D., Millevoi, S., Vagner, S. Tags: Endocrinology Source Type: journals

Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conventional development of multivariate gene expression models (GEM) predicting therapeutic response of cancer patients is based on analysis of patients treated with specific regimens, which limits generalization to different or novel drug combinations. We overcome this limitation by developing GEMs based on in vitro drug sensitivities and microarray analyses of the NCI-60 cancer cell line panel. These GEMs were evaluated in blind fashion as predictors of tumor response and/or patient survival in seven independent cohorts of patients with breast (n = 275), bladder (n = 59), and ovarian (n= 143) cancer treated with multiag...
Source: Cancer Research - October 29, 2009 Category: Cancer & Oncology Authors: Williams, P. D., Cheon, S., Havaleshko, D. M., Jeong, H., Cheng, F., Theodorescu, D., Lee, J. K. Tags: Clinical Research Source Type: journals

Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in patients with locally advanced rectal cancer (LARC).Between 2004 and 2006, 28 patients with LARC (cT2-T4, N0-N2) were treated with neoadjuvant chemoradiation. Total radiation dose was 50.4 Gy and daily dose was 1.8 Gy in 5.5 weeks. Capecitabine was administrated 1,650 mg/m2/day, 7 days/week. Preoperative staging was based on combined computer tomography and endorectal ultrasound. Tissue samples...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: C.S. Boskos, C. Liacos, D. Korkolis, K. Aygerinos, I. Lamproglou, E. Terpos, E. Stoupa, G. Baltatzis, K. Beroukas, P. Papasavvas, M.A. Dimopoulos, A. Bamias Source Type: journals

The role of PET CT to evaluate the response to neoadjuvant chemotherapy in advanced breast cancer: Comparison with ultrasonography and magnetic resonance imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is aimed to estimate the predictive role of PET CT and other imaging modalities (ultrasound, MRI) through NAC.PET CT was acquired before and after NAC from 41 patients. Pathologic results were classified as pathological complete response (pCR) and non-pCR. The results of clinical responses were assessed with imaging indexes (postTx, postchemotherapy size or peak standardized uptake values (pSUV); delta, the size difference between treatment; RR, reduction rate of tumor size or pSUV), and they were compared with pathologic results.Seven patients (17.1%) showed pCR. As a result of comparison of the image index, al...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Jae Hyuck Choi, Hye In Lim, Se Kyung Lee, Wan Wook Kim, Sang Min Kim, EunYoon Cho, Eun Young Ko, Boo-Kyung Han, Yeon Hee Park, Jin-Seok Ahn, Young-Hyuck Im, Jeong Eon Lee, Jung-Hyun Yang, Seok Jin Nam Source Type: journals

Extended bile duct resection liver and transplantation in patients with hilar cholangiocarcinoma: Long-term resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the overall long-term survival was relatively low in our inhomogeneous cohort but favorable in patients without metastases. However, because of the increased perioperative mortality, EBDR is not recommended as a standard procedure for hilar cholangiocarcinoma instead of LT alone. To further improve the results, other approaches such as (neo)adjuvant therapy have to be increasingly investigated. Liver Transpl 15:1499-1507, 2009. © 2009 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - October 28, 2009 Category: Transplant Surgery Authors: Daniel Seehofer, Armin Thelen, Ulf P. Neumann, Winfried Veltzke-Schlieker, Timm Denecke, Carsten Kamphues, Johann Pratschke, Sven Jonas, Peter Neuhaus Tags: Original Articles Source Type: journals

Long-term results of sleeve lobectomy in the management of non-small cell lung carcinoma and low-grade neoplasms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Sleeve lobectomy can be performed with minimal bronchial anastomotic complications and low postoperative mortality. In our study, neoadjuvant therapy for non-small cell lung cancer adversely influenced the rate of anastomotic complications. Performing sleeve lobectomy for patients with N1 disease was not associated with decreased overall survival rates. PMID: 19853115 [PubMed - in process] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 27, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Merritt RE, Mathisen DJ, Wain JC, Gaissert HA, Donahue D, Lanuti M, Allan JS, Morse CR, Wright CD Tags: Ann Thorac Surg Source Type: journals

Rectal cancer: quo vadis, neoadjuvant and adjuvant (chemo) radiotherapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Invited CommentaryDOI 10.1007/s00384-009-0825-9Authors Rainer Fietkau, University of Erlangen Department of Radiotherapy Erlangen Germany Journal International Journal of Colorectal DiseaseOnline ISSN 1432-1262Print ISSN 0179-1958 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 26, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals

Why Are Pretreatment Prostate-specific Antigen Levels And Biochemical Recurrence Poor Predictors Of Prostate Cancer Survival?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
UroToday.com - In the online edition of Cancer, Dr. James Denham and colleagues evaluated the initial, pretreatment PSA (iPSA) level as a prognostic predictor of prostate cancer (CaP) survival. A cohort of 802 patients from Australia and New Zealand received radiotherapy (XRT) with either 0, 3, or 6 months of neoadjuvant androgen deprivation therapy (ADT). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 26, 2009 Category: Consumer Health News Tags: Prostate / Prostate Cancer Source Type: news

Successful treatment of neoadjuvant therapy for papillary tumor of the pineal regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a boy who in 1994, at the age of 11, presented with headache and vomiting. The fi nal diagnosis was papillary tumor of the pineal region (PTPR). Magnetic resonance imaging (MRI) revealed a heterogeneous mass. Hydrocephalus was addressed by immediate ventricle drainage; subsequently, we attempted tumor removal. As the intraoperative diagnosis of the hemorrhagic tumor was primitive neuroectodermal tumor (PNET), we did not proceed to total removal. After the delivery of radiotherapy (50.4 Gy) and one course of Nimustine hydrochloride (ACNU) chemotherapy, the residual tumor was completely resected. The diagnosis ...
Source: Brain Tumor Pathology - October 26, 2009 Category: Neurology Tags: Brain Tumor Pathology Source Type: journals

Chemoradiotherapy for cancer of the esophagus: contribution of the leucovorin, 5-fluorouracil bolus, and infusion–cisplatin–radiotherapy schedule starting with two neoadjuvant chemotherapy cycles: results from a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess feasibility and tolerance of a modification in the usual radiochemotherapy regimen for esophageal cancer by using a leucovorin, 5-fluorouracil bolus, and infusion[ndash]cisplatin regimen (six cycles), beginning with two cycles of chemotherapy before conventional radiotherapy (50 Gy), 33 patients, 30 were men, 62.8 ± 9.5 years, were treated for an esophageal carcinoma (29 squamous cell), 27 of these were in stage III (based on computed tomography scan). Neoadjuvant chemotherapy was well tolerated; concomitant radiochemotherapy was associated with severe adverse events mostly hematological in 23 patients. Complete...
Source: Diseases of the Esophagus - October 26, 2009 Category: Gastroenterology Authors: T. N. Tran Vuong, E. Le Prisé, E. Vauléon, E. Boucher, O. Audrain, J.-L. Raoul Source Type: journals

The effect of Gleason score on the predictive value of prostate-specific antigen doubling timeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate the influence of the pathological Gleason score on the predictive value of the prostate-specific antigen (PSA) doubling time (DT), as this variable predicts a patient's risk of disease progression both before and after definitive therapy for prostate cancer, and there is an inverse correlation between the Gleason score and PSA production. We evaluated all men treated with radical prostatectomy (RP) between 1990 and 1999 who did not receive neoadjuvant or adjuvant therapy. We identified 2296 patients who had multiple PSA values available before RP, and 1323 who had biochemical recurrence after RP and had at leas...
Source: BJU International - October 26, 2009 Category: Urology & Nephrology Authors: Matthew K. Tollefson, Michael L. Blute, Laureano J. Rangel, Erik J. Bergstralh, Stephen A. Boorjian, R. Jeffrey Karnes Source Type: journals

Cardiac safety of trastuzumab as adjuvant treatment for Japanese patients with early breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The incidence of cardiac events caused by trastuzumab treatment was low in our analysis. Adjuvant trastuzumab treatment for up to at least 1 year should be safe for Japanese breast cancer patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-009-0898-zAuthors Mikiya Ishihara, National Cancer Center Hospital East Division of Oncology/Hematology 6-5-1 Kashiwanoha, Kashiwa Chiba 277-8577 JapanHirofumi Mukai, National Cancer Center Hospital East Division of Oncology/Hematology 6-5-1 Kashiwanoha, Kashiwa Chiba 277-8577 JapanShunji Nagai, National Cancer Center Hospital...
Source: International Journal of Clinical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: journals

Systematic Review of Randomized and Nonrandomized Trials of the Clinical Response and Outcomes of Neoadjuvant Systemic Chemotherapy for Resectable Colorectal Liver MetastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Current evidence suggests that objective response to neoadjuvant chemotherapy may be achieved with improvement in DFS in patients with resectable CLM. A prospective randomized trial of neoadjuvant therapy versus adjuvant therapy after liver resection is required to determine the optimal perisurgical treatment regimen. Content Type Journal ArticleCategory Hepatobiliary TumorsDOI 10.1245/s10434-009-0781-1Authors Terence C. Chua, University of New South Wales Department of Surgery, St George Hospital Kogarah Sydney AustraliaAkshat Saxena, University of New South Wales Department of Surgery, St...
Source: Annals of Surgical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

A Systematic Review of Resectability and Survival After Concurrent Chemoradiation in Primarily Unresectable Pancreatic CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The finding of a high proportion of R0 resection among all resections performed confirms the activity of neoadjuvant radiochemotherapy and should not be neglected. Based on these data, patients with unresectable pancreatic cancer without disease progression after chemoradiotherapy should be considered for radical surgery. Content Type Journal ArticleCategory Radiation OncologyDOI 10.1245/s10434-009-0762-4Authors Alessio G. Morganti, Catholic University Department of Radiation Oncology, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences Campobasso It...
Source: Annals of Surgical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Study Finds No Relationship Between PCR Rate And Race In Women With Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Locally advanced breast cancer patients who received the same class of neoadjuvant chemotherapy were found to have no evidence of disease at the time of their surgery, or achieved pathological complete response, at the same rate regardless of race, according to researchers at The University of Texas M. D. Anderson Cancer Center. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - October 24, 2009 Category: Cancer & Oncology Source Type: news

Neoadjuvant Capecitabine Added to Standard Treatment Helps to Eradicate Tumors in PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Data from the Austrian Breast and Colorectal Cancer Study Group (ABCSG)-24 study presented at the joint 15th ECCO and 34th ESMO congress in Berlin, show that adding capecitabine (Xeloda) to anthracycline- and taxane-containing regimens prior to surgery completely eradicated the tumor in 24% of women with HER2-positive or HER2-negative early breast cancer. This is an impressive finding since the proportion of women achieving total tumor eradication with standard chemotherapy for HER2-positive or HER2-negative early breast cancer is less than 20% (range = 6%–18%). (Source: Cancer Network)
Source: Cancer Network - October 23, 2009 Category: Cancer & Oncology Source Type: info