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This page shows you the latest news and research items in this category.

Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis
Toftgard & T J McDonnell (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - May 17, 2013 Category: Cytology Authors: N S ChariR A RomanoM I KosterV JaksD RoopE R FloresS TeglundS SinhaW GruberF AbergerL J MedeirosR ToftgardT J McDonnell Tags: SUFU TP63 BCL2 keratinocyte differentiation non-melanoma skin cancer Source Type: research

Does Skin Cancer Protect Against Alzheimer's? (CME/CE)
(MedPage Today) -- Older patients with nonmelanoma skin cancer showed less risk of developing Alzheimer's disease than those without, researchers reported. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - May 15, 2013 Category: Primary Care Source Type: news

Influence of reflected UV irradiance on occupational exposure from combinations of reflective wall surfaces
Photochem. Photobiol. Sci., 2013, Accepted ManuscriptDOI: 10.1039/C3PP50059D, PaperJoanna Turner, Alfio V ParisiOutdoor workers who occupationally spend large periods of time exposed to ultraviolet irradiance are at increased risk of developing certain types of non-melanoma skin cancer in addition to being prone...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Photochem. Photobiol. Sci. latest articles)
Source: RSC - Photochem. Photobiol. Sci. latest articles - May 3, 2013 Category: Chemistry Authors: Joanna Turner Source Type: research

Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin
Nicotinamide (vitamin B3) protects from ultraviolet (UV) radiation-induced carcinogenesis in mice and from UV-induced immunosuppression in mice and humans. Recent double-blinded randomized controlled Phase 2 studies in heavily sun-damaged individuals have shown that oral nicotinamide significantly reduces premalignant actinic keratoses, and may reduce new non-melanoma skin cancers. Nicotinamide is a precursor of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in adenosine triphosphate (ATP) production. Previously, we showed that nicotinamide prevents UV-induced ATP decline in HaCaT keratinocytes. Energy-dep...
Source: Carcinogenesis - May 3, 2013 Category: Cancer & Oncology Authors: Surjana, D., Halliday, G. M., Damian, D. L. Tags: Original Manuscript Source Type: research

A Pilot Split‐Face Study Comparing Conventional Methyl Aminolevulinate‐Photodynamic Therapy (PDT) With Microneedling‐Assisted PDT on Actinically Damaged Skin
ConclusionMicroneedling‐assisted PDT is a safe and effective method and can produce superior cosmetic results to conventional MAL‐PDT for improving photodamaged skin. Further larger prospective studies are needed to determine whether the addition of MN decreases actinic keratosis. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - May 2, 2013 Category: Dermatology Authors: Luís Torezan, Yuri Chaves, Ane Niwa, José A. Sanches, Cyro Festa‐Neto, Rolf‐Markus Szeimies Tags: Original Articles Source Type: research

Skin Cancer Tx No Help for Sick Older Patients? (CME/CE)
(MedPage Today) -- Surgical treatment of nonmelanoma skin cancer in elderly patients with other underlying health conditions may do more harm than good, researchers found. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 29, 2013 Category: Cardiology Source Type: news

Should old, sick patients get skin cancer surgery?
NEW YORK (Reuters Health) - More than two-thirds of people with non-melanoma skin cancer underwent surgery to treat the condition, according to a new study - including patients who were at least 85 years old or had multiple other chronic diseases. (Source: Reuters: Health)
Source: Reuters: Health - April 29, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Should Old, Sick Patients Get Skin Cancer Surgery?
More than two-thirds of people with non-melanoma skin cancer underwent surgery to treat the condition, according to a new study - including patients who were at least 85 years old or had multiple other chronic diseases.Source: Reuters Health Related MedlinePlus Page: Skin Cancer (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - April 29, 2013 Category: Consumer Health News Source Type: news

Should Old, Sick Patients Have Surgery for Skin Cancer?Should Old, Sick Patients Have Surgery for Skin Cancer?
More than two-thirds of people with non-melanoma skin cancer had surgery to treat the condition in a new study, including patients at least 85 years old or with multiple chronic diseases. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 29, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Skin cancer may increase subsequent primary malignancy risk
Research suggests that people with non-melanoma skin cancer are at moderately increased risk for developing other primary malignancies in the future, particularly breast and lung cancer and melanoma. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - April 26, 2013 Category: Dermatology Source Type: news

A Light Emitting Diode (LED) Based Spatial Frequency Domain Imaging System for Optimization of Photodynamic Therapy of Nonmelanoma Skin Cancer: Quantitative Reflectance Imaging
ConclusionsSFDI can be used to quantitatively characterize in vivo tissue optical properties that could be useful for better informing PDT treatment parameters. Specifically, this information provides spatially resolved insight into light delivery into tissue and local tissue oxygenation, thereby providing more quantitative and controlled dosimetry specific to the lesion. Ultimately, by optimizing the execution of PDT, this instrument has the potential to positively improve treatment outcomes. Lasers Surg. Med. 9999:XX–XX, 2013. © 2013 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)
Source: Lasers in Surgery and Medicine - April 26, 2013 Category: Laser Surgery Authors: R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, A. J. Durkin Tags: Basic Science Source Type: research

Skin cancer may increase subsequent primary malignancy risk
Research suggests that people with non-melanoma skin cancer are at moderately increased risk for developing other primary malignancies in the future, particularly breast and lung cancer and melanoma. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - April 25, 2013 Category: Cancer & Oncology Source Type: news

Skin cancer may increase subsequent primary malignancy risk
Research suggests that people with non-melanoma skin cancer are at moderately increased risk for developing other primary malignancies in the future, particularly breast and lung cancer and melanoma. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - April 25, 2013 Category: Respiratory Medicine Source Type: news

Prospective study of genital human papillomaviruses and nonmelanoma skin cancer
In conclusion, we found prospective evidence that HPV16 and 18 antibodies associate with SCC and other NMSC risk, but not with BCC risk. As only a small proportion of seropositive subjects had evidence of the corresponding HPV DNA in the tumor, most of this excess risk is likely to be due to confounders associated with genital HPV infection. (Source: International Journal of Cancer)
Source: International Journal of Cancer - April 25, 2013 Category: Cancer & Oncology Authors: Kristin Andersson, Tapio Luostarinen, Anna Söderlund Strand, Hilde Langseth, Randi E. Gislefoss, Ola Forslund, Michael Pawlita, Tim Waterboer, Joakim Dillner Tags: Epidemiology Source Type: research

The Link Between Non-Melanoma Skin Cancer And Indoor Tanning
The widespread liking for sunbeds continues to place a huge amount of individuals at risk of developing non-melanoma skin cancer. Adding further concern to the link between sunbeds and non-melanoma cancer was a recent study carried out by the University of California, San Francisco. The results of the study were reported on the UCSF website, and predominantly warned that sunbed users are in greater danger the younger they begin to use indoor tanning equipment. Basal cell carcinomas are the growths that appear on the skin and these are categorised as the most common type of skin cancer... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 24, 2013 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Non-Melanoma Skin Cancers Tied to Risk for Other Cancers
Title: Non-Melanoma Skin Cancers Tied to Risk for Other CancersCategory: Health NewsCreated: 4/23/2013 6:36:00 PMLast Editorial Review: 4/24/2013 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - April 24, 2013 Category: Cancer & Oncology Source Type: news

Non-Melanoma Skin Cancer Linked To Future Risk Of Other Forms Of Cancers
White people who have types of skin cancer other than melanoma (non-melanoma skin cancer) may be at increased risk of having other forms of cancer in the future, according to a study by US researchers published in this week's PLOS Medicine. The analysis, led by Dr... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 23, 2013 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study
Conclusion This prospective study found a modestly increased risk of subsequent malignancies among individuals with a history of NMSC, specifically breast and lung cancer in women and melanoma in both men and women.Please see later in the article for the Editors' Summary (Source: PLoS Medicine)
Source: PLoS Medicine - April 23, 2013 Category: Internal Medicine Authors: Fengju Song et al. Source Type: research

Non-Melanoma Skin Cancers Tied to Risk for Other Cancers
Findings come from two large, long-term studies of U.S. health professionals (Source: Fertility News - Doctors Lounge)
Source: Fertility News - Doctors Lounge - April 23, 2013 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Gynecology, Oncology, Reproductive Medicine, News, Source Type: news

Researchers Observe an Increased Risk of Cancer in People with History of Non-melanoma Skin Cancer
In a study, people with a history of non-melanoma skin cancer had a modestly increased risk of getting cancer in the future, specifically breast and lung cancer in women and melanoma in both men and women (Source: BWH for Journalists)
Source: BWH for Journalists - April 22, 2013 Category: Research Source Type: news

Researchers Observe an Increased Risk of Cancer in People with History of Non-melanoma Skin Cancer
In a study, people with a history of non-melanoma skin cancer had a modestly increased risk of getting cancer in the future, specifically breast and lung cancer in women and melanoma in both men and women (Source: BWH News)
Source: BWH News - April 22, 2013 Category: Hospital Management Source Type: news

The association between TP53 Arg72pro polymorphism and non-melanoma skin cancer risk: A meta-analysis including 7,107 subjects
Conclusions: TP53 Arg72Pro polymorphism may have little involvement in the pathogenesis of NMSC, regardless of type, including SCC, and BCC. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - April 20, 2013 Category: Dermatology Authors: Xueling YangBaohong YangYa LiuShanshan XuBo Li Source Type: research

The Hospital de Cancer de Barretos Registry: an analysis of cancer survival at a single institution in Brazil over a 10-year period
Conclusions: During this ten-year period, the Hospital de Cancer de Barretos Registry collected, processed and analysed data related to all cases treated at the institution, providing relevant information about patient characteristics and survival. (Source: BMC Research Notes)
Source: BMC Research Notes - April 10, 2013 Category: Research Authors: Estela CarnesecaEdmundo MauadMarcos AraújoRafael DalboAdhemar Longatto FilhoVinícius Vazquez Source Type: research

UVR exposure through window glass may be associated with localization of nonmelanoma skin cancer in organ transplant recipients: a study in France and the United Kingdom
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - April 1, 2013 Category: Dermatology Authors: R. Atkar, M. Ocampo, S. Euvard, J. McGregor, J. Kanitakis, C. Harwood Tags: Correspondence Source Type: research

Two-Year Randomized Controlled Prospective Trial Converting Treatment of Stable Renal Transplant Recipients With Cutaneous Invasive Squamous Cell Carcinomas to Sirolimus [Cancer Prevention and Control]
Conclusion Conversion to sirolimus-based immunosuppression failed to show a benefit in terms of SCC-free survival at 2 years. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - March 29, 2013 Category: Cancer & Oncology Authors: Hoogendijk-van den Akker, Harden, Hoitsma, Proby, Wolterbeek, Bouwes Bavinck, de Fijter Tags: Non-Melanoma Skin Cancer Cancer Prevention and Control Source Type: research

Long‐term safety of ustekinumab in patients with moderate‐to‐severe psoriasis: final results from 5 years of follow‐up
Conclusions No dose‐related or cumulative toxicity was observed with increasing duration of ustekinumab exposure for up to 5 years. Rates of AEs reported in ustekinumab psoriasis trials are generally comparable with those reported for other biologics approved for the treatment of moderate‐to‐severe psoriasis. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - March 25, 2013 Category: Dermatology Authors: K.A. Papp, C.E.M. Griffiths, K. Gordon, M. Lebwohl, P.O. Szapary, Y. Wasfi, D. Chan, M.‐C. Hsu, V. Ho, P.D. Ghislain, B. Strober, K. Reich, Tags: THERAPEUTICS Source Type: research

Merkel cell polyomavirus large T antigen is detected in rare cases of nonmelanoma skin cancer
ConclusionsOur results suggest that the frequent detection of the MCPyV genome in NMSC by PCR reflects ubiquitous spread of the virus. However, the low immunohistochemical detection rate of MCPyV and the lack of MCC‐specific MCPyV mutations argue against an essential role of MCPyV in the development of skin cancers other than MCC. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - March 23, 2013 Category: Pathology Authors: Kirsten D. Mertz, Aino Paasinen, Andreas Arnold, Michèle Baumann, Felix Offner, Niels Willi, Gieri Cathomas Tags: Original Article Source Type: research

Immunotherapy: A vehicle for inflammation
Nature Reviews Cancer 13, 221 (2013). doi:10.1038/nrc3505 Author: Darren J. Burgess Aldara is a topical cream formulation of imiquimod (IMQ) that stimulates an antitumour inflammatory immune response for the treatment of non-melanoma skin cancers. Walter et al. examined the effects of Aldara on the skin of healthy mice and found that much of the inflammatory (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 22, 2013 Category: Cancer & Oncology Authors: Darren J. Burgess Tags: Research Highlight Source Type: research

Saving face the Mohs way
Mohs surgery is now considered the definitive treatment for non- melanoma skin cancers, writesMIKE MILOTTE (Source: The Irish Times - Health)
Source: The Irish Times - Health - March 6, 2013 Category: Consumer Health News Source Type: news

HIV Infection Status, Immunodeficiency, and the Incidence of Non-Melanoma Skin Cancer
Conclusion HIV+ subjects had a twofold higher incidence rate of NMSCs compared with HIV– subjects. SCCs but not BCCs were associated with immunodeficiency. (Source: JNCI)
Source: JNCI - March 5, 2013 Category: Cancer & Oncology Authors: Silverberg, M. J., Leyden, W., Warton, E. M., Quesenberry, C. P., Engels, E. A., Asgari, M. M. Tags: Article Source Type: research

Introduction
The incidence of head and neck melanoma and non-melanoma cutaneous malignancy is rising in the United States and worldwide. These malignancies can be the source of significant patient morbidity and mortality depending on the histology, stage, and risk features. It is important for otolaryngologists to be familiar with the presentation and treatment of these cancers. Patients frequently present to otolaryngologists with head and neck skin lesions as their primary complaint. Additionally, concerning skin lesions are often noted incidentally on otolaryngologists' head and neck exams. Because they have training in both head an...
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - March 1, 2013 Category: ENT & OMF Authors: Genevieve A. Andrews Source Type: research

Appearance of cutaneous malignancies of the head and neck
The spectrum of cutaneous malignancies of the head and neck ranges from tumors that are fairly well behaved, such as the majority of basal cell carcinomas, to very aggressive cancers with a high metastatic rate, such as Merkel cell carcinoma. Most forms of cutaneous malignancy have characteristic clinical presentations, which assist in their clinical diagnosis. The goal of this article is to review the appearances and clinical presentations of common nonmelanoma skin cancers (basal and squamous cell carcinomas), uncommon nonmelanoma skin cancers (Merkel cell carcinoma and dermatofibrosarcoma protuberans), and the various s...
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - March 1, 2013 Category: ENT & OMF Authors: Genevieve Andrews, Bryan Anderson, Rogerio Neves Source Type: research

Primary resection of cutaneous malignancies of the head and neck
Cutaneous malignancies, which commonly occur in the head and neck, are the most common cancers in the United States, and are composed primarily of the nonmelanoma skin cancers, basal cell carcinoma, and squamous cell carcinoma. Mohs micrographic surgery is often preferred over wide local excision for these nonmelanoma skin cancers of the head and neck. However, wide local excision is still the preferred method of primary resection for specific cutaneous malignancies of the head and neck. The purpose of this article is to describe the indications, preoperative workup, and technique for the primary surgical resection of cuta...
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - March 1, 2013 Category: ENT & OMF Authors: Genevieve Andrews Source Type: research

Lymphadenectomy for anterior cutaneous malignancies of the head and neck
Cutaneous cancer is the most common malignancy in the United States. Basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and Merkel cell carcinoma (MCC) represent the nonmelanoma category and correspond to 3.5 million skin cancers annually. Melanoma, a more aggressive skin cancer with a higher propensity for regional metastases, represents 5% of all diagnosed skin cancers, but 75% of skin cancer related deaths. Appropriate evaluation and management of regional lymph nodes is an important part of workup, staging and prognosis. Cervical lymphadenectomy in anterior cutaneous malignancies is dependent on the histology ...
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - March 1, 2013 Category: ENT & OMF Authors: Jennifer R. Cracchiolo, Jeffrey C. Liu Source Type: research

Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease
Conclusions Analysis of adverse events of interest through nearly 12 years of adalimumab exposure in clinical trials across indications demonstrated individual differences in rates by disease populations, no new safety signals and a safety profile consistent with known information about the anti-TNF class. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 25, 2013 Category: Rheumatology Authors: Burmester, G. R., Panaccione, R., Gordon, K. B., McIlraith, M. J., Lacerda, A. P. M. Tags: Inflammatory bowel disease, Open access, Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological resear Source Type: research

Frequency and spectrum of metachronous malignancies in heart transplant recipients: a 11-year-experience at a German heart center.
CONCLUSIONS: Incidence of various cancer types among HTX patients in this survey was consistent with previous studies, with lung and skin cancer as the commonest malignancies encountered. Regular cancer screening may be of benefit in reducing morbidity and mortality in these patients. PMID: 23412350 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Strecker T, Rösch J, Weyand M, Agaimy A Tags: Int J Clin Exp Pathol Source Type: research

Are non-melanoma skin cancer incomplete excision rates different between grades of plastic surgeons?
Non-melanoma skin cancers (NMSCs) are increasing in incidence and worldwide there are currently 2–3 million new cases each year. In the majority of departments, local anaesthetic (LA) day case NMSC surgery is undertaken by all grades of surgeon and is considered a valuable training opportunity. When NMSC excision margins are involved, the recommendation is usually for re-excision, radiotherapy or close outpatient follow-up. All of these have a negative effect on patient experience and incur additional financial costs. In an era where demand is increasing on limited resources and risk-adjusted clinical performance data is...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - February 18, 2013 Category: Cosmetic Surgery Authors: Kai Yuen Wong, Onur Gilleard, Richard D. Price Tags: Correspondence and Communications - E-Only Publication Source Type: research

Development of a Plaque Infiltrated With Large CD30+ T Cells Over a Silicone-Containing Device in a Patient With History of Sezary Syndrome [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 15, 2013 Category: Cancer & Oncology Authors: Engberg, Bunick, Subtil, Ko, Girardi Tags: Non-Melanoma Skin Cancer, Immunology/Immunobiology DIAGNOSIS IN ONCOLOGY Source Type: research

Pituitary tumor‐transforming gene 1 as a proliferation marker lacking prognostic value in cutaneous squamous cell carcinoma
Abstract Nonmelanoma skin cancer is the most frequently‐occurring type of cancer worldwide and is caused by epidermal carcinogenesis and malignant progression that involve dysregulated expression of proto‐oncogenes and tumor suppressor genes. The proto‐oncogene pituitary tumor‐transforming gene 1 (PTTG1) is a ubiquitously expressed transcription factor that can promote enhanced proliferation of cultured epidermal keratinocytes. To the investigate the potential roles of PTTG1 in epidermal carcinogenesis and malignant progression, the expression of PTTG1 was analyzed by immunohistochemistry along with Ki67, keratin 1...
Source: Experimental Dermatology - February 15, 2013 Category: Dermatology Authors: Yosuke Ishitsuka, Yasuhiro Kawachi, Shijima Taguchi, Hiroshi Maruyama, Yoshiyuki Nakamura, Yasuhiro Fujisawa, Jun‐ichi Furuta, Yasuhiro Nakamura, Yoshiyuki Ish, Fujio Otsuka Tags: Regular Article Source Type: research

Use of Azathioprine for Non-Thymoma Myasthenia and Risk of Cancer: A Nationwide Case-Control Study in Denmark (P02.191)
CONCLUSIONS: Use of azathioprine in non-thymoma MG patients may be associated with a slightly increased risk of overall cancer. Larger studies are warranted to address the risk of site specific cancers.Disclosure: Dr. Pedersen has nothing to disclose. Dr. Pottegaard has nothing to disclose. Dr. Hallas has received personal compensation for activities with the Association of Danish Pharmaceutical Industry. Dr. Friis has nothing to disclose. Dr. Hansen has received royalty payments from ThermoFisher Scientific. Dr. Jensen has nothing to disclose. Dr. Gaist has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Pedersen, E., Pottegaard, A., Hallas, J., Friis, S., Hansen, K., Jensen, P. E., Gaist, D. Tags: P02 Myasthenia Gravis: Treatment Issues Source Type: research

Increased Risk of Skin Cancer in Myasthenia Patients Treated with Azathioprine: A Nationwide Case-Control Study in Denmark (P02.192)
CONCLUSIONS: Long-term use of azathioprine in MG patients increases the risk of NMSC.Disclosure: Dr. Pedersen has nothing to disclose. Dr. Pottegaard has nothing to disclose. Dr. Hallas has received personal compensation for activities with the Association of Danish Pharmaceutical Industry. Dr. Friis has nothing to disclose. Dr. Hansen has received royalty payments from ThermoFisher Scientific. Dr. Jensen has nothing to disclose. Dr. Gaist has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Pedersen, E., Pottegaard, A., Hallas, J., Friis, S., Hansen, K., Jensen, P. E., Gaist, D. Tags: P02 Myasthenia Gravis: Treatment Issues Source Type: research

Sunburn in children and adolescents: associations with parents' behaviour and attitudes.
Conclusions: Interventions to influence the attitudes and behaviour of parents could reduce their children's risk for excessive sun exposure and thereby their risk for melanoma and non-melanoma skin cancer. The results encourage preventive campaigns to focus on changing parental attitudes towards tanned skin and sun behaviour. PMID: 23392996 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Public Health)
Source: Scandinavian Journal of Public Health - February 7, 2013 Category: Global & Universal Authors: Behrens CL, Thorgaard C, Philip A, Bentzen J Tags: Scand J Public Health Source Type: research

Patient‐reported outcome measures in nonmelanoma skin cancer of the face: a systematic review
Summary Nonmelanoma skin cancer (NMSC) is the most common malignancy in the western world, with an incidence of 98 000 in the U.K. Since 2009 the Department of Health (DoH) has collected patient‐reported outcome measure (PROM) data following four common surgical procedures. However, a DoH PROM for NMSC does not exist. A systematic review of questionnaires published on patient concerns due to NMSC of the face was conducted. Keywords relevant to PROMs, NMSC and the facial region were comprehensively searched in medical databases. Inclusion criteria stipulated questionnaires from relevant papers that recruited patients wit...
Source: British Journal of Dermatology - February 6, 2013 Category: Dermatology Authors: A.S. Bates, C.R. Davis, A. Takwale, G.J. Knepil Tags: Review Article Source Type: research

Patient-reported outcome measures in nonmelanoma skin cancer of the face: a systematic review.
Abstract Nonmelanoma skin cancer (NMSC) is the most common malignancy in the western world, with an incidence of 98 000 in the U.K. Since 2009 the Department of Health (DoH) has collected patient-reported outcome measure (PROM) data following four common surgical procedures. However, a DoH PROM for NMSC does not exist. A systematic review of questionnaires published on patient concerns due to NMSC of the face was conducted. Keywords relevant to PROMs, NMSC and the facial region were comprehensively searched in medical databases. Inclusion criteria stipulated questionnaires from relevant papers that recruited patie...
Source: The British Journal of Dermatology - February 6, 2013 Category: Dermatology Authors: Bates AS, Davis CR, Takwale A, Knepil GJ Tags: Br J Dermatol Source Type: research

Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma
Ultraviolet B (UVB) light is the major environmental carcinogen contributing to non-melanoma skin cancer (NMSC) development. There are over 3.5 million NMSC diagnoses in two million patients annually, with men having a 3-fold greater incidence of squamous cell carcinoma (SCC) compared with women. Chronic inflammation has been linked to tumorigenesis, with a key role for the cyclooxygenase-2 (COX-2) enzyme. Diclofenac, a COX-2 inhibitor and non-steroidal anti-inflammatory drug, currently is prescribed to patients as a short-term therapeutic agent to induce SCC precursor lesion regression. However, its efficacy as a preventa...
Source: Carcinogenesis - February 5, 2013 Category: Cancer & Oncology Authors: Burns, E. M., Tober, K. L., Riggenbach, J. A., Schick, J. S., Lamping, K. N., Kusewitt, D. F., Young, G. S., Oberyszyn, T. M. Tags: Original Manuscript Source Type: research

ANCA-associated vasculitis and malignancy: Current evidence for cause and consequence relationships
In this review, we summarise the current understanding of the potential link between cancer and anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (Wegener's; GPA) and microscopic polyangiitis (MPA). As is true for many autoimmune or inflammatory rheumatic diseases, AAV diagnosis and therapy are associated with an increased risk of de novo cancer development, likely as a result of impaired immunosurveillance, direct oncogenicity of immunosuppressive agents and perhaps malignant degeneration of tissues undergoing chronic immune stimulation. Data from several studies ...
Source: Best Practice and Research. Clinical Rheumatology - February 1, 2013 Category: Rheumatology Authors: Alfred Mahr, Caroline Heijl, Guillaume Le Guenno, Mikkel Faurschou Source Type: research

Nonmelanoma Skin Cancer
Nonmelanoma skin cancer (NMSC) is the most common form of malignancy in humans. The incidence of NMSC continues to increase despite increased awareness and sun-protective measures. If neglected or mismanaged, NMSC can cause significant morbidity and even death. The most common forms of NMSC on the head and neck include basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma, eccrine porocarcinoma, Merkel cell carcinoma, atypical fibroxanthoma, and microcystic adnexal carcinoma. Surgery is the mainstay of treatment (standard excision, Mohs micrographic surgery, curettage); however, other modalities exist, includi...
Source: Facial Plastic Surgery Clinics of North America - January 31, 2013 Category: Cosmetic Surgery Authors: Lauren E. Dubas, Adam Ingraffea Source Type: research

HIV Patients At Two-Fold Higher Risk For Non-Melanoma Skin Cancers
HIV-positive patients have a higher incidence of non-melanoma skin cancers, according to a Kaiser Permanente study that appears in the current online issue of the Journal of the National Cancer Institute. Specifically, basal cell and squamous cell carcinomas occur more than twice as often among HIV-positive individuals compared to those who are HIV-negative. The study cohort of 6,560 HIV-positive and almost 37,000 HIV-negative subjects was drawn from members of Kaiser Permanente Northern California from 1996 to 2008. Overall, HIV-positive subjects had a 2... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 31, 2013 Category: Consumer Health News Tags: HIV / AIDS Source Type: news

Cancer death rates are a third higher in men
The fact that men are more likely than women to both develop and die from cancer has been covered by most of the media today. The news is based on a report highlighting the excess cancer burden in men (both in terms of cases and deaths), and was produced by Cancer Research UK, the Men’s Health Forum and the National Cancer Intelligence Network. The results of the report were widely and accurately reported in the media. The report found that men are at significantly greater risk of both developing and dying from cancer, and the difference in risk increased further when breast and sex-specific cancers, for example cervi...
Source: NHS News Feed - January 29, 2013 Category: Consumer Health News Tags: Cancer QA articles Source Type: news

Study reveals 2-fold higher incidence of non-melanoma skin cancers for HIV patients
(Kaiser Permanente) HIV-positive patients have a higher incidence of non-melanoma skin cancers, according to a Kaiser Permanente study that appears in the current online issue of the Journal of the National Cancer Institute. Specifically, basal cell and squamous cell carcinomas occur more than twice as often among HIV-positive individuals compared to those who are HIV-negative. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 29, 2013 Category: Global & Universal Source Type: news