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This page shows you the latest news and research items in this category.

Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease
Conclusions Analysis of adverse events of interest through nearly 12 years of adalimumab exposure in clinical trials across indications demonstrated individual differences in rates by disease populations, no new safety signals and a safety profile consistent with known information about the anti-TNF class. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 25, 2013 Category: Rheumatology Authors: Burmester, G. R., Panaccione, R., Gordon, K. B., McIlraith, M. J., Lacerda, A. P. M. Tags: Inflammatory bowel disease, Open access, Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological resear Source Type: research

Frequency and spectrum of metachronous malignancies in heart transplant recipients: a 11-year-experience at a German heart center.
CONCLUSIONS: Incidence of various cancer types among HTX patients in this survey was consistent with previous studies, with lung and skin cancer as the commonest malignancies encountered. Regular cancer screening may be of benefit in reducing morbidity and mortality in these patients. PMID: 23412350 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Strecker T, Rösch J, Weyand M, Agaimy A Tags: Int J Clin Exp Pathol Source Type: research

Development of a Plaque Infiltrated With Large CD30+ T Cells Over a Silicone-Containing Device in a Patient With History of Sezary Syndrome [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 15, 2013 Category: Cancer & Oncology Authors: Engberg, Bunick, Subtil, Ko, Girardi Tags: Non-Melanoma Skin Cancer, Immunology/Immunobiology DIAGNOSIS IN ONCOLOGY Source Type: research

Pituitary tumor‐transforming gene 1 as a proliferation marker lacking prognostic value in cutaneous squamous cell carcinoma
Abstract Nonmelanoma skin cancer is the most frequently‐occurring type of cancer worldwide and is caused by epidermal carcinogenesis and malignant progression that involve dysregulated expression of proto‐oncogenes and tumor suppressor genes. The proto‐oncogene pituitary tumor‐transforming gene 1 (PTTG1) is a ubiquitously expressed transcription factor that can promote enhanced proliferation of cultured epidermal keratinocytes. To the investigate the potential roles of PTTG1 in epidermal carcinogenesis and malignant progression, the expression of PTTG1 was analyzed by immunohistochemistry along with Ki67, keratin 1...
Source: Experimental Dermatology - February 15, 2013 Category: Dermatology Authors: Yosuke Ishitsuka, Yasuhiro Kawachi, Shijima Taguchi, Hiroshi Maruyama, Yoshiyuki Nakamura, Yasuhiro Fujisawa, Jun‐ichi Furuta, Yasuhiro Nakamura, Yoshiyuki Ish, Fujio Otsuka Tags: Regular Article Source Type: research

Use of Azathioprine for Non-Thymoma Myasthenia and Risk of Cancer: A Nationwide Case-Control Study in Denmark (P02.191)
CONCLUSIONS: Use of azathioprine in non-thymoma MG patients may be associated with a slightly increased risk of overall cancer. Larger studies are warranted to address the risk of site specific cancers.Disclosure: Dr. Pedersen has nothing to disclose. Dr. Pottegaard has nothing to disclose. Dr. Hallas has received personal compensation for activities with the Association of Danish Pharmaceutical Industry. Dr. Friis has nothing to disclose. Dr. Hansen has received royalty payments from ThermoFisher Scientific. Dr. Jensen has nothing to disclose. Dr. Gaist has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Pedersen, E., Pottegaard, A., Hallas, J., Friis, S., Hansen, K., Jensen, P. E., Gaist, D. Tags: P02 Myasthenia Gravis: Treatment Issues Source Type: research

Increased Risk of Skin Cancer in Myasthenia Patients Treated with Azathioprine: A Nationwide Case-Control Study in Denmark (P02.192)
CONCLUSIONS: Long-term use of azathioprine in MG patients increases the risk of NMSC.Disclosure: Dr. Pedersen has nothing to disclose. Dr. Pottegaard has nothing to disclose. Dr. Hallas has received personal compensation for activities with the Association of Danish Pharmaceutical Industry. Dr. Friis has nothing to disclose. Dr. Hansen has received royalty payments from ThermoFisher Scientific. Dr. Jensen has nothing to disclose. Dr. Gaist has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Pedersen, E., Pottegaard, A., Hallas, J., Friis, S., Hansen, K., Jensen, P. E., Gaist, D. Tags: P02 Myasthenia Gravis: Treatment Issues Source Type: research

Sunburn in children and adolescents: associations with parents' behaviour and attitudes.
Conclusions: Interventions to influence the attitudes and behaviour of parents could reduce their children's risk for excessive sun exposure and thereby their risk for melanoma and non-melanoma skin cancer. The results encourage preventive campaigns to focus on changing parental attitudes towards tanned skin and sun behaviour. PMID: 23392996 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Public Health)
Source: Scandinavian Journal of Public Health - February 7, 2013 Category: Global & Universal Authors: Behrens CL, Thorgaard C, Philip A, Bentzen J Tags: Scand J Public Health Source Type: research

Patient‐reported outcome measures in nonmelanoma skin cancer of the face: a systematic review
Summary Nonmelanoma skin cancer (NMSC) is the most common malignancy in the western world, with an incidence of 98 000 in the U.K. Since 2009 the Department of Health (DoH) has collected patient‐reported outcome measure (PROM) data following four common surgical procedures. However, a DoH PROM for NMSC does not exist. A systematic review of questionnaires published on patient concerns due to NMSC of the face was conducted. Keywords relevant to PROMs, NMSC and the facial region were comprehensively searched in medical databases. Inclusion criteria stipulated questionnaires from relevant papers that recruited patients wit...
Source: British Journal of Dermatology - February 6, 2013 Category: Dermatology Authors: A.S. Bates, C.R. Davis, A. Takwale, G.J. Knepil Tags: Review Article Source Type: research

Patient-reported outcome measures in nonmelanoma skin cancer of the face: a systematic review.
Abstract Nonmelanoma skin cancer (NMSC) is the most common malignancy in the western world, with an incidence of 98 000 in the U.K. Since 2009 the Department of Health (DoH) has collected patient-reported outcome measure (PROM) data following four common surgical procedures. However, a DoH PROM for NMSC does not exist. A systematic review of questionnaires published on patient concerns due to NMSC of the face was conducted. Keywords relevant to PROMs, NMSC and the facial region were comprehensively searched in medical databases. Inclusion criteria stipulated questionnaires from relevant papers that recruited patie...
Source: The British Journal of Dermatology - February 6, 2013 Category: Dermatology Authors: Bates AS, Davis CR, Takwale A, Knepil GJ Tags: Br J Dermatol Source Type: research

Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma
Ultraviolet B (UVB) light is the major environmental carcinogen contributing to non-melanoma skin cancer (NMSC) development. There are over 3.5 million NMSC diagnoses in two million patients annually, with men having a 3-fold greater incidence of squamous cell carcinoma (SCC) compared with women. Chronic inflammation has been linked to tumorigenesis, with a key role for the cyclooxygenase-2 (COX-2) enzyme. Diclofenac, a COX-2 inhibitor and non-steroidal anti-inflammatory drug, currently is prescribed to patients as a short-term therapeutic agent to induce SCC precursor lesion regression. However, its efficacy as a preventa...
Source: Carcinogenesis - February 5, 2013 Category: Cancer & Oncology Authors: Burns, E. M., Tober, K. L., Riggenbach, J. A., Schick, J. S., Lamping, K. N., Kusewitt, D. F., Young, G. S., Oberyszyn, T. M. Tags: Original Manuscript Source Type: research

Nonmelanoma Skin Cancer
Nonmelanoma skin cancer (NMSC) is the most common form of malignancy in humans. The incidence of NMSC continues to increase despite increased awareness and sun-protective measures. If neglected or mismanaged, NMSC can cause significant morbidity and even death. The most common forms of NMSC on the head and neck include basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma, eccrine porocarcinoma, Merkel cell carcinoma, atypical fibroxanthoma, and microcystic adnexal carcinoma. Surgery is the mainstay of treatment (standard excision, Mohs micrographic surgery, curettage); however, other modalities exist, includi...
Source: Facial Plastic Surgery Clinics of North America - January 31, 2013 Category: Cosmetic Surgery Authors: Lauren E. Dubas, Adam Ingraffea Source Type: research

HIV Patients At Two-Fold Higher Risk For Non-Melanoma Skin Cancers
HIV-positive patients have a higher incidence of non-melanoma skin cancers, according to a Kaiser Permanente study that appears in the current online issue of the Journal of the National Cancer Institute. Specifically, basal cell and squamous cell carcinomas occur more than twice as often among HIV-positive individuals compared to those who are HIV-negative. The study cohort of 6,560 HIV-positive and almost 37,000 HIV-negative subjects was drawn from members of Kaiser Permanente Northern California from 1996 to 2008. Overall, HIV-positive subjects had a 2... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 31, 2013 Category: Consumer Health News Tags: HIV / AIDS Source Type: news

Cancer death rates are a third higher in men
The fact that men are more likely than women to both develop and die from cancer has been covered by most of the media today. The news is based on a report highlighting the excess cancer burden in men (both in terms of cases and deaths), and was produced by Cancer Research UK, the Men’s Health Forum and the National Cancer Intelligence Network. The results of the report were widely and accurately reported in the media. The report found that men are at significantly greater risk of both developing and dying from cancer, and the difference in risk increased further when breast and sex-specific cancers, for example cervi...
Source: NHS News Feed - January 29, 2013 Category: Consumer Health News Tags: Cancer QA articles Source Type: news

Study reveals 2-fold higher incidence of non-melanoma skin cancers for HIV patients
(Kaiser Permanente) HIV-positive patients have a higher incidence of non-melanoma skin cancers, according to a Kaiser Permanente study that appears in the current online issue of the Journal of the National Cancer Institute. Specifically, basal cell and squamous cell carcinomas occur more than twice as often among HIV-positive individuals compared to those who are HIV-negative. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 29, 2013 Category: Global & Universal Source Type: news

Effects of folic acid supplementation on overall and site-specific cancer incidence during randomised trials: meta-analyses of data on 50,000 individuals
Source: Lancet Area: News Some countries fortify flour with folic acid to prevent neural tube defects but others do not, partly because of concerns about possible cancer risks. In The Lancet, researchers present new data that contribute to the debate regarding folic acid and cancer. They conducted a meta-analysis to assess any effects on site-specific cancer rates in the randomised trials of folic acid supplementation, at doses higher than those for fortification. A search was conducted for trials completed before 2011 that compared folic acid with placebo, had scheduled treatment duration at least 1 year, incl...
Source: NeLM - News - January 25, 2013 Category: Drugs & Pharmacology Source Type: news

Nine out of 10 sunbeds have 'unsafe' UV levels
Conclusion This well-conducted and useful study suggests that, on average, the UV exposure from tanning units throughout England is higher than the recent standard level introduced throughout the EU, and that cancer risk from the average level of radiation seen across these units is more than twice that of the midday summer Mediterranean sun. The researchers say that there is a recent trend of increasing UV levels, and that this coincides "with the development of new high-power sunlamps". There are some discrepancies between the reporting of this research and the methods used in the study. Some newspapers reporte...
Source: NHS News Feed - January 17, 2013 Category: Consumer Health News Tags: Cancer Source Type: news

Nonmelanoma Skin Cancer Visits and Procedure Patterns in a Nationally Representative Sample: National Ambulatory Medical Care Survey 1995–2007
ConclusionsNonmelanoma skin cancer visit rates increased from 1995 to 2007 and were higher in men than women. Visits to a dermatologist are more likely to be associated with a procedure for NMSC, and there may be discrepancies in treatment patterns based on insurance type and sex. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - January 17, 2013 Category: Dermatology Authors: Ashley Wysong, Eleni Linos, Tina Hernandez‐Boussard, Sarah T. Arron, Hayes Gladstone, Jean Y. Tang Tags: Original Article Source Type: research

Photodynamic Therapy in Mycosis Fungoides.
This article reviews the literature and the practical application of photodynamic therapy in mycosis fungoides. PMID: 23332865 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - January 17, 2013 Category: Dermatology Authors: Fernández-Guarino M, Jaén-Olasolo P Tags: Actas Dermosifiliogr Source Type: research

Digital compression of facial arteries facilitates cutaneous nasal surgery.
Abstract Non-melanoma skin cancers on the nose frequently present to dermatology for surgical excision. This anatomical area has an excellent vascular supply and, consequently, increased intra-operative bleeding (Fig. 1 (a)). Pinching the nasal tip to control bleeding is commonly used, however this can be uncomfortable for the patient because the nasal septum may not be anaesthetised (Fig. 1 (b)). PMID: 23301876 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Moran B, Foley C, Ormond P Tags: Br J Dermatol Source Type: research

Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from five years of follow-up.
CONCLUSIONS: No dose-related or cumulative toxicity was observed with increasing duration of ustekinumab exposure for up to five years. Rates of AEs reported in ustekinumab psoriasis trials are generally comparable to those reported for other biologics approved for the treatment of moderate-to-severe psoriasis. PMID: 23301632 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Papp KA, Griffiths CE, Gordon K, Lebwohl M, Szapary PO, Wasfi Y, Chan D, Hsu MC, Ho V, Ghislain PD, Strober B, Reich K, The PHOENIX 1, PHOENIX 2, ACCEPT Investigators Tags: Br J Dermatol Source Type: research

'Addressing' an under-recognised cause of discomfort for patients undergoing Mohs micrographic surgery.
Abstract Mohs micrographic surgery (MMS) is acknowledged as the gold-standard treatment for high risk non-melanoma skin cancer of the head and neck. By virtue of its tissue-sparing nature, patients who undergo MMS may require several stages or 'layers' to successfully extirpate a tumour. Under such circumstances it is commonplace for adhesive dressings to be applied between each stage to cover an exposed wound bed and act as a temporary pressure dressing to reduce the risk of bleeding. PMID: 23301598 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Parker J, Norman D, Savage L, Hussain W Tags: Br J Dermatol Source Type: research

Risk Factors for Non-melanoma Skin Cancer in Kidney Transplant Patients in a Spanish Population in the Mediterranean Region.
Abstract Non-melanoma skin cancer (NMSC) is the most frequent malignancy in organ transplant recipients. The aetiology of NMSC after transplant is multifactorial. The aim of this study was to determine the clinical and environmen-tal factors involved in the development of NMSC in a Spanish kidney transplant population from the Mediterranean region. A total of 289 patients who had received a kidney transplant during the period January 1996 to December 2010 were included in the study. Both prospective and retrospective data were used. All patients underwent a structured interview and a complete examination of the ski...
Source: Acta Dermato-Venereologica - January 10, 2013 Category: Dermatology Authors: García JB, Suárez-Varela MM, Vilata JJ, Marquina A, Pallardó L, Crespo J Tags: Acta Derm Venereol Source Type: research

Long‐term safety of ustekinumab in patients with moderate‐to‐severe psoriasis: final results from 5 years of follow‐up
ConclusionsNo dose‐related or cumulative toxicity was observed with increasing duration of ustekinumab exposure for up to 5 years. Rates of AEs reported in ustekinumab psoriasis trials are generally comparable to those reported for other biologics approved for the treatment of moderate‐to‐severe psoriasis. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: K.A. Papp, C.E.M. Griffiths, K. Gordon, M. Lebwohl, P.O. Szapary, Y. Wasfi, D. Chan, M.‐C. Hsu, V. Ho, P.D. Ghislain, B. Strober, K. Reich, Tags: Original Article Source Type: research

Nonmelanoma skin cancer in Australia.
PMID: 23278555 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 1, 2013 Category: Dermatology Authors: Sinclair R Tags: Br J Dermatol Source Type: research

Capecitabine to Reduce Nonmelanoma Skin Carcinoma Burden in Solid Organ Transplant Recipients
ConclusionsSOTRs experienced a clinically and statistically significant decline in incident SCCs during treatment with low‐dose oral capecitabine, with varying degrees of side effects. Larger randomized trials will determine the dose and efficacy of capecitabine for adjuvant treatment of NMSC in SOTRs. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - January 1, 2013 Category: Dermatology Authors: Bart Endrizzi, Rehana L. Ahmed, Theresa Ray, Arkadiusz Dudek, Peter Lee Tags: Original Article Source Type: research

Vitiligo: the white armor?
The difficulty in the management of the patient with vitiligo is that long‐term UVB narrowband phototherapy is the recognized mainstay for treatment contrasting with the fact that dermatologists warn constantly their patients about the dangers of sun exposure to limit skin aging and cancer. Ambivalent reasoning has not a great appeal in the profession and many dermatologists just prefer to give vitiligo patients sunscreens for white skin and advice for reinforced photoprotection. In this context, the retrospective study by Teulings et al. in a Dutch population indicating that patients with vitiligo have a decreased risk ...
Source: Pigment Cell Research - January 1, 2013 Category: Cytology Authors: Alain Taïeb, Khaled Ezzedine Tags: News & Views Source Type: research

Tumor necrosis factor α inhibitor therapy and cancer risk in chronic immune‐mediated diseases
ConclusionShort‐term cancer risk was not elevated among patients treated with TNFα inhibitor therapy relative to commonly used therapies for immune‐ mediated chronic inflammatory diseases in this study. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 27, 2012 Category: Rheumatology Authors: Kevin Haynes, Timothy Beukelman, Jeffrey R. Curtis, Craig Newcomb, Lisa J. Herrinton, David J. Graham, Daniel H. Solomon, Marie R. Griffin, Lang Chen, Liyan Liu, Kenneth G. Saag, James D. Lewis, Tags: Rheumatoid Arthritis Source Type: research

Incidence of Residual Nonmelanoma Skin Cancer in Excisions After Shave Biopsy
ConclusionThe rate of residual nonmelanoma carcinoma in excision specimens after shave biopsy was found to be different from previously reported in the literature. These data may have therapeutic ramifications if further substantiated. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - December 26, 2012 Category: Dermatology Authors: Kurt Grelck, Sean Sukal, Les Rosen, Gabriel P. Suciu Tags: Original Article Source Type: research

Non-melanoma skin cancer in mouse and man.
Abstract As a frontier organ, skin is exposed to different environmental and/or occupational chemicals which cause cutaneous cancers in experimental animals. In mice, 7,12-dimethylbenz[a]anthrancene (DMBA) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) are frequently used as skin model tumor initiator and promoter, respectively. The sequential administration of DMBA and TPA leads to the appearance of a large number of benign papillomas, of which some convert later into invasive squamous cell carcinomas (SCC). At the molecular level, initiation of carcinogenesis in mouse skin consists in the mutati...
Source: Archives of Toxicology - December 25, 2012 Category: Toxicology Authors: Schwarz M, Münzel PA, Braeuning A Tags: Arch Toxicol Source Type: research

Nonmelanoma skin cancer in Australia
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - December 21, 2012 Category: Dermatology Authors: Rodney Sinclair Tags: EDITORIAL Source Type: research

Weather conditions and daylight‐mediated photodynamic therapy: protoporphyrin IX‐weighted daylight doses measured in six geographical locations
Conclusions Where and when to perform daylight‐PDT depends on the PpIX light dose and outdoor temperature. The PpIX light dose was influenced by the geographical location (latitude), weather condition and time of year. The UV index was not more suitable than temperature and weather to predict if the intensity of daylight would be sufficient for daylight‐PDT. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - December 21, 2012 Category: Dermatology Authors: S.R. Wiegell, S. Fabricius, J. Heydenreich, C.D. Enk, S. Rosso, W. Bäumler, B.T. Baldursson, H.C. Wulf Tags: PHOTOBIOLOGY Source Type: research

Are low levels of 25-hydroxyvitamin D a risk factor for cardiovascular diseases or malignancies in renal transplantation?
Conclusions Our data suggested that low vitamin D levels were not associated with an increased risk of cardiovascular diseases or malignancies. However, due to the small number of patients and events, the results should not be considered as definitive. Additional studies with a higher number of patients are required to elucidate the true impact of vitamin D status on cardiovascular and malignancy risks. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - December 20, 2012 Category: Urology & Nephrology Authors: Marcen, R., Jimenez, S., Fernandez-Rodriguez, A., Galeano, C., Villafruela, J. J., Gomis, A., Teruel, J. L., Quereda, C. Tags: Original articles Source Type: research

βKlotho regulates the differentiation and tumorgenesis of epidermal keratinocytes
klotho gene is a putative aging suppressor gene. Klotho protein exists in two forms: membrane Klotho and secreted Klotho. The secreted Klotho has been suggested to have anti-oxidative stress/anti-cancer properties partially by inhibiting type I insulin-like growth factor receptor (IGF-IR)/extracellular signal-regulated kinase (ERK) 1/2 activity in some human organs. βKlotho is a member of the Klotho protein family. Immunohistological analysis revealed that the expression of βKlotho protein was reduced in the lesion of human squamous cell carcinoma (SCC) and diminished in the lesion of basal cell carcinoma (BCC) compared ...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Kozo Nakai, Shigeaki Inoue, Reiji Haba, Yoshio Kushida, Nahomi Katsuki, Yoichiro Hosokawa, Tetsuya Moriue, Kozo Yoneda, Yasuo Kubota Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Human papillomavirus infection in Bowen disease
Human papillomavirus (HPV) is one of the well-known risk factors of many epithelial malignancies of the oral cavity, larynx, and skin, as well as the cervix. Among the non-melanoma skin cancers, Bowen disease (BD) of the genitalia and fingers has been shown to be strongly linked to the high-risk types of HPV infection, especially HPV 16. Recently, there have been several case reports of HPV-associated BD on other locations as well; however, there are only several reports demonstrating the frequencies of HPV infection in BD lesions. The skin specimens of 142 BD lesions from 136 patients were investigated clinicopathological...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Kazutoshi Murao, Yoshiaki Kubo Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

The long-term treatments of topical vitamin D3 inhibit the UV-induced skin tumor formation in a mouse model
In conclusion, topical calcitriol is more effective for tumor progression rather than tumor initiation and can be used as a chemopreventive agent, but it needs very careful approach because the adverse effects occur when the treated area is extensive. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Jiwon Gye, Donghye Kim, Minyoung Jung, Jae-Hong Kim, Jiyeon Yoo, Sung-Ku Ahn, Eung-Ho Choi, Seung-Phil Hong Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Vitiligo lowers melanoma risk
Patients with vitiligo may have a lower risk for developing melanoma and nonmelanoma skin cancer, according to findings of a recent study. (Source: Modern Medicine)
Source: Modern Medicine - December 19, 2012 Category: Journals (General) Source Type: news

Pattern of HPV infection in basal cell carcinoma and in perilesional skin biopsies from immunocompetent patients
Conclusions: These findings demonstrate that beta-HPV types belonging to species 1 are the most common HPV types detected in the skin of BCC patients. Moreover beta-1-HPV types and mixed infections are significantly more frequent in tumour samples than in healthy perilesional skin. Our results suggest that beta-1-HPVs as well as co-infection with more than one viral type could be important in NMSC and in particular in BCC.Further studies aimed to compare the biological activity of viral types in tumours and in healthy skin (viral replication and expression, interference of infection with cellular functions) are necessary t...
Source: Virology Journal - December 17, 2012 Category: Virology Authors: Krystyna ZakrzewskaElisa RegalbutoFederica PierucciRosaria ArviaSandra MazzoliAlessia GoriVincenzo de Giorgi Source Type: research

Cyclo-oxygenase-2 inhibitors for chemoprevention of nonmelanoma skin cancer: Is there a role for these agents?
Selective cyclo-oxygenase (COX)-2 inhibitors have been proposed as potentially useful agents in the chemoprevention of nonmelanoma skin cancer (NMSC). Although COX-2 inhibitors are not without considerable risks, they may hold benefit for certain patient subgroups at risk for NMSC. In this article, we review studies examining the use of these agents in cancer prevention, and offer suggestions for future investigations with oral and topical COX-2 inhibitors in the prevention of NMSC. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - December 13, 2012 Category: Dermatology Authors: Tracey N. Liebman, Jennifer A. Stein, David Polsky Tags: Commentary Source Type: research

Incidences of overall and site specific cancers in TNF{alpha} inhibitor treated patients with rheumatoid arthritis and other arthritides - a follow-up study from the DANBIO Registry
Conclusions Our results suggest that TNF-I therapy in routine care is not associated with an overall excess of cancer in arthritis patients, but observed increased risks of colon and ovarian cancer need further investigation. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - December 12, 2012 Category: Rheumatology Authors: Dreyer, L., Mellemkjaer, L., Andersen, A. R., Bennett, P., Poulsen, U. E., Juulsgaard Ellingsen, T., Hansen, T. H., Jensen, D. V., Linde, L., Lindegaard, H. M., Loft, A. G. R., Nordin, H., Omerovic, E., Rasmussen, C., Schlemmer, A., Tarp, U., Hetland, M. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research

[Risk of non-melanoma skin cancer under TNF inhibition : New aspects from the British Biologics Register.]
[Risk of non-melanoma skin cancer under TNF inhibition : New aspects from the British Biologics Register.] Z Rheumatol. 2012 Dec 9; Authors: Zink A PMID: 23223913 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - December 9, 2012 Category: Rheumatology Authors: Zink A Tags: Z Rheumatol Source Type: research

Detection of mucosal type human papillomavirus in cutaneous squamous cell carcinoma in Iran.
Abstract Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer. The oncogenic role of human papilloma virus (HPV) in cutaneous SCC has been suggested by several studies performed on immunosuppresed patients. However, the role of mucosal type HPV in SCC patients with normal immunity has not been studied extensively. Sixty skin biopsies from immunocompetent SCC patients and 60 benign skin specimens were evaluated for mucosal type HPV DNA using polymerase chain reaction (PCR) and immunohistochemistry (IHC). Mucosal type HPV DNA was detected in 18 of 60 cases (30%) and in 7 of 60 controls (11...
Source: Pathology, Research and Practice - December 5, 2012 Category: Pathology Authors: Shayanfar N, Hosseini N, Panahi M, Azadmanesh K, Mohammadpour M, Kadivar M, Mirzaie AZ, Sohrabi A Tags: Pathol Res Pract Source Type: research

Safety profile of belimumab: pooled data from placebo-controlled phase 2 and 3 studies in patients with systemic lupus erythematosus.
Abstract Safety data were pooled and analyzed from one phase 2 and two phase 3 double-blind, placebo-controlled, repeat-dose systemic lupus erythematosus (SLE) trials of belimumab 1, 4 (phase 2 only), and 10 mg/kg. Types and rates of adverse events (AEs) were similar across treatment groups. Rates of patients experiencing any serious AE were 16.6%, 19.5%, 13.5%, and 18.0% with placebo, and belimumab 1, 4, and 10 mg/kg, respectively; rates of serious infusion reactions (including hypersensitivity reactions) occurring on the same days as infusions were 0.4%, 0.9%, 0%, and 0.9%, and rates of serious infections wer...
Source: Lupus - December 4, 2012 Category: Rheumatology Authors: Wallace D, Navarra S, Petri M, Gallacher A, Thomas M, Furie R, Levy R, van Vollenhoven R, Cooper S, Zhong Z, Freimuth W, Cervera R, for the BLISS-52 and -76, and LBSL02 Study Groups Tags: Lupus Source Type: research

A Collision of Diseases: Chronic Lymphocytic Leukemia Discovered During Lymph Node Biopsy for Melanoma
Conclusions We have confirmed an increased association of CLL and melanoma. This may be related to an underlying immunologic defect; however, there has been scant investigation into this phenomenon. Surgeons and pathologists should understand this occurrence and recognize that not all grossly enlarged or abnormal sentinel lymph nodes in melanoma patients represent melanoma. Content Type Journal ArticleCategory MelanomasPages 1-5DOI 10.1245/s10434-012-2740-5Authors Jeffrey M. Farma, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USAJonathan S. Zager, Department of Cutaneo...
Source: Annals of Surgical Oncology - November 26, 2012 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: research

Reconstructing skin cancers using animal models
Abstract The American Cancer Society estimates that skin cancer is the most prevalent of all cancers with over 2 million cases of nonmelanoma skin cancer each year and 75,000 melanoma cases in 2012. Representative animal cancer models are important for understanding the underlying molecular pathogenesis of these cancers and the development of novel targeted anticancer therapeutics. In this review, we will discuss some of the important animal models that have been useful to identify important pathways involved in basal cell carcinoma, squamous cell carcinoma, and melanoma. Content Type Journal ArticlePag...
Source: Cancer and Metastasis Reviews - November 25, 2012 Category: Cancer & Oncology Tags: Cancer and Metastasis Reviews Source Type: research

The risk of developing non‐melanoma skin cancer, lymphoma and melanoma in patients with psoriasis in Taiwan: a 10‐year, population‐based cohort study
Conclusions Psoriasis carries an elevated risk of NMSC and lymphoma. This effect is modified by the severity of psoriasis, age, gender, and geographic location. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - November 21, 2012 Category: Dermatology Authors: Meng‐Sui Lee, Ruey‐Yi Lin, Yun‐Ting Chang, Mei‐Shu Lai Tags: Report Source Type: research

Non-melanoma skin cancer in Australia.
CONCLUSION: NMSC treatments increased by 86% between 1997 and 2010. We anticipate that the number and the total cost without inflation of NMSC treatments will increase by a further 22% between 2010 and 2015. NMSC will remain the most costly cancer and place an increasing burden on the Australian health care system. PMID: 23163687 [PubMed - in process] (Source: Med J Aust)
Source: Med J Aust - November 19, 2012 Category: Journals (General) Authors: Fransen M, Karahalios A, Sharma N, English DR, Giles GG, Sinclair RD Tags: Med J Aust Source Type: research

Sensus Healthcare Announces Health Canada Approval
Sensus Healthcare, providers of the SRT-100, the leading alternative for non surgical skin cancer treatment, announces that it has received a Medical Device License from Health Canada, permitting the marketing and sale of its device for treating skin cancer patients. The SRT-100™ is a state-of-the-art therapy device for Non Melanoma Skin Cancer (Source: Medical Design Online News)
Source: Medical Design Online News - November 18, 2012 Category: Medical Equipment Source Type: news

Vitiligo patients have low risk for skin cancer
Evidence suggests that patients with vitiligo have a reduced risk for both melanoma and nonmelanoma skin cancer. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - November 16, 2012 Category: Dermatology Source Type: news

Vitiligo patients have low risk for skin cancer
Evidence suggests that patients with vitiligo have a reduced risk for both melanoma and nonmelanoma skin cancer. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - November 16, 2012 Category: Cancer & Oncology Source Type: news

Pain and nonmelanoma skin cancer in transplant patients
To the Editor: Nonmelanoma skin cancer (NMSC) is the most common cancer in the United States. Approximately 80% of NMSCs are basal cell carcinomas (BCCs) and 20% are squamous-cell carcinomas (SCCs). Transplant patients are at an increased risk for developing numerous, frequently aggressive NMSCs. Considering that skin cancers are so frequent in this population, bedside tools to aid the physician in diagnosing these cancers would be of significant clinical utility. Thus the aim of the present study was to identify unique symptoms of NMSCs in this population. A striking finding of this analysis was the association of pain ...
Source: Journal of the American Academy of Dermatology - November 16, 2012 Category: Dermatology Authors: Shawn G. Kwatra, Kyle C. Mills, Alex Zeitany, Daniel J. Pearce, Phillip M. Williford, Ralph B. D'Agostino, Gil Yosipovitch Tags: Research Letters Source Type: research