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This page shows you the latest news and research items in this category.

Onychomycosis in close quarter living review of the literature
Summary Onychomycosis is defined as a fungal infection of the nail bed and/or nail plate. The prevalence of onychomycosis has increased dramatically as a worldwide condition in the twentieth century due to occlusive footwear, global wars and natural migration. Risk factors generally leading to onychomycosis development include bodily spread of dermatophyte and non‐dermatophyte tinea pedis, peripheral vascular disease, damaged nails via sports and trauma, older age, genetics, immunodeficiency and diabetes. Many publications discuss prevalence, symptoms and treatment of the disease in individual cases, hospitals or specifi...
Source: Mycoses - May 14, 2013 Category: Research Authors: Michael I. Gazes, Joshua Zeichner Tags: Review Article Source Type: research

An assessment of the genetic toxicology of novel boron‐containing therapeutic agents
Boron‐containing compounds are being studied as potential therapeutic agents. As part of the safety assessment of these therapeutic agents, a battery of genetic toxicology studies was conducted. The battery included a bacterial reverse mutation (Ames) assay, an in vitro chromosome aberration assay in peripheral human lymphocytes, and an in vivo rat micronucleus study. The following compounds represent some of the boron‐containing compounds that have been advanced to human clinical trials in various therapeutic areas. The borinic picolinate, AN0128, is an antibacterial compound with anti‐inflammatory activity that has...
Source: Environmental and Molecular Mutagenesis - April 29, 2013 Category: Molecular Biology Authors: Vic Ciaravino, Jacob Plattner, Sanjay Chanda Tags: Research Article Source Type: research

Dermatophyte isolation in the socks of patients with tinea pedis and onychomycosis
(Source: The Journal of Dermatology)
Source: The Journal of Dermatology - April 27, 2013 Category: Dermatology Authors: Alexandro Bonifaz, Denisse Vázquez‐González, Marco Antonio Hernández, Javier Araiza, Andrés Tirado‐Sánchez, Rosa María Ponce Tags: Letter to the Editor Source Type: research

Efficacy of 4 weeks topical bifonazole treatment for onychomycosis after nail ablation with 40% urea: a double‐blind, randomized, placebo‐controlled multicenter study
Summary Onychomycosis is a common fungal infection most often affecting the toenails. If untreated, it can cause discomfort sufficient to reduce quality of life. To evaluate efficacy and safety of bifonazole cream vs. placebo in onychomycosis treatment after non‐surgical nail ablation with urea paste. Fifty‐one study centres randomized 692 subjects with mild‐to‐moderate onychomycosis to receive bifonazole 1% cream or placebo for 4 weeks following non‐surgical nail ablation with urea 40% paste over 2–4 weeks. Efficacy of the two phase treatment was evaluated by overall cure of the target nail comprising clin...
Source: Mycoses - April 23, 2013 Category: Research Authors: Hans‐Jürgen Tietz, Roderick Hay, Susanne Querner, Andreas Delcker, Peter Kurka, Hans F. Merk Tags: Original article Source Type: research

Fungal skin infections: current approaches to management
Abstract The dermatophyte skin infections tinea capitis, tinea pedis and onychomycosis are common and challenging to treat. Our Drug review focusses on key points and advances in their management, followed by further sources of information. (Source: Prescriber)
Source: Prescriber - April 22, 2013 Category: Primary Care Authors: Nicola Salmon, Claire Fuller Tags: Drug Review Source Type: research

Onychomycosis due to Rhizomucor in psoriatic patient with HIV infection
We report an unusual case of onychomycosis in an HIV-positive psoriatic patient caused by Rhizomucor pusillus, which has not been mentioned in the literature before. Our finding underline the fact that fungal species appearing as contaminants should be evaluated by proper clinical-mycological correlation to ensure an accurate diagnosis. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - April 20, 2013 Category: Dermatology Authors: Ravinder KaurShwetaMonika Matlani Source Type: research

Efficacy of NVC‐422 in the treatment of dermatophytosis caused by Trichophyton mentagrophytes using a guinea pig model
Conclusions Evaluation of the efficacy of NVC‐422 in the treatment of dermatophytosis using an experimental guinea pig model showed that this compound possesses potent antifungal efficacy as measured by mycological and clinical endpoints. The highest degree of clinical and mycological efficacy was demonstrated by 2% NVC‐422 in 1% Noveon Gel. These data show that NVC‐422 has potent antifungal activity in vivo. Clinical evaluation of NVC‐422 in the treatment of superficial infections caused by dermatophytes, including onychomycosis, is warranted. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - April 17, 2013 Category: Dermatology Authors: Mahmoud A. Ghannoum, Lisa Long, Amber J. Cirino, Anthony R. Miller, Ron Najafi, Lu Wang, Kuldeepak Sharma, Mark Anderson, Bahram Memarzadeh Tags: Report Source Type: research

An observational and descriptive study of the epidemiology of and therapeutic approach to onychomycosis in dermatology offices in Brazil
CONCLUSION: This study was important to describe the epidemiological behavior of onychomycosis in Brazilian dermatology offices and to determine important risk factors, such as gender, age, practice of exercises, personal history of the disease, and comorbidities. BACKGROUND: Fundamentos: As onicomicoses são infecções fúngicas que representam mais de 50% de todas onicopatias e são consideradas por alguns autores a micose superficial de mais difícil tratamento. Poucos estudos foram feitos para investigar a epidemiologia da onicomicose no Brasil. OBJETIVO: Descrever perfil epidemiol�...
Source: Anais Brasileiros de Dermatologia - April 13, 2013 Category: Dermatology Source Type: research

Identification and antifungal susceptibility of fungi isolated from dermatomycoses
ConclusionYeasts, particularly C. parapsilosis, play an important role as causative agents of dermatomycosis in our region. Our results suggest that the antifungal susceptibility testing coupled with proper identification of the fungi may be useful to assist clinicians in determining the appropriate therapy for dermatomycoses. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - April 5, 2013 Category: Dermatology Authors: L.B. Silva, D.B.C. Oliveira, B.V. Silva, R.A. Souza, P.R. Silva, K. Ferreira‐Paim, L.E. Andrade‐Silva, M.L. Silva‐Vergara, A.A. Andrade Tags: Original Article Source Type: research

Randomized controlled trial comparing photodynamic therapy based on methylene blue dye and fluconazole for toenail onychomycosis
Abstract Photodynamic therapy (PDT) is a medical modality that uses a combination of visible light and a photosensitive compound in the presence of oxygen. It is widely used to treat non‐melanoma skin cancer; other indications are being investigated, especially onychomycosis. Eighty patients with toenail onychomycosis were enrolled and completed this randomized, parallel, placebo‐controlled study. For 24 weeks, 40 patients (Group A) were treated with one placebo capsule per week and sessions of 2% methylene blue aqueous solution irradiated with light emission diode device (MBLED/PDT) with 18 J/cm2; and another 40 pat...
Source: Dermatologic Therapy - April 1, 2013 Category: Dermatology Authors: L. W. Figueiredo Souza, S. V. T. Souza, A. C. C. Botelho Tags: Therapeutic Hotline Source Type: research

Quality of life in patients with toenail onychomycosis
This study was undertaken to assess health‐related quality of life (HRQoL) in patients with toenail onychomycosis. The Onychomycosis QoL questionnaire (ONYCHO), as a disease‐specific instrument, and the Short Form 36 Health Survey (SF‐36) as a generic instrument, were applied in 140 consecutive patients affected by onychomycosis. Women and patients who were experiencing toenail onychomycosis for more than 2 years were reporting worse disease‐specific HRQoL. The patients working in blue‐collar occupations and patients with greater involvement of individual nails were more affected by onychomycosis regarding sympt...
Source: Mycoses - March 18, 2013 Category: Research Authors: Danica Milobratović, Slavenka Janković, Jelica Vukičević, Jelena Marinković, Janko Janković, Zoran Railić Tags: Original article Source Type: research

Hyperkeratotic warty skin lesion of foot caused by Fusarium oxysporum
We report a case of hyperkeratotic verrucous warty skin lesion in the foot of a 50-year-old immunocompetent male, farmer by occupation. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - March 5, 2013 Category: Dermatology Authors: Ravinder KaurMegha Maheshwari Source Type: research

Dermatologist‐diagnosed skin diseases among immigrant Latino poultry processors and other manual workers in North Carolina, USA
Conclusions Several skin diseases are highly prevalent in immigrant Latino workers and may relate to work environment. These may impair the quality of life of these workers and predispose them to further illness. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - March 3, 2013 Category: Dermatology Authors: Rita Pichardo‐Geisinger, Diana Muñoz‐Ali, Thomas A. Arcury, Jill N. Blocker, Joseph G. Grzywacz, Dana C. Mora, Haiying Chen, Mark R. Schulz, Steve R. Feldman, Sara A. Quandt Tags: Report Source Type: research

Aspergillus terreus complex: an emergent opportunistic agent of Onychomycosis
Summary The incidence of onychomycosis due to non‐dermatophyte moulds (NDM) is increasing. Aspergillus terreus is relatively undocumented as an agent of this fungal infection. The aim of this work is to show the prevalence of onychomycosis caused by A. terreus and to describe its clinical features. Nail samples were collected for microscopic examination and culturing in selective media. All cases of onychomycosis due to NDM were confirmed by a second sample. Aspergillus terreus isolates were identified through their morphological characteristics and using molecular methods. A total of 2485 samples were obtained. Positive...
Source: Mycoses - March 1, 2013 Category: Research Authors: Mariana S. Fernández, Florencia D. Rojas, María E. Cattana, María Sosa, Magdalena L. Mangiaterra, Gustavo E. Giusiano Tags: Original Article Source Type: research

Superficial white onychomycosis due to Trichophyton rubrum in a two-year-old child
Gong Yu, Wu JianhuaIndian Journal of Dermatology, Venereology, and Leprology 2013 79(2):269-269 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - February 22, 2013 Category: Dermatology Authors: Gong YuWu Jianhua Source Type: research

Comparison of direct microscopic methods using potassium hydroxide, periodic acid Schiff, and calcofluor white with culture in the diagnosis of onychomycosis
Sachin Yadav, AK Saxena, Malini R Capoor, V RameshIndian Journal of Dermatology, Venereology, and Leprology 2013 79(2):242-243 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - February 22, 2013 Category: Dermatology Authors: Sachin YadavAK SaxenaMalini R CapoorV Ramesh Source Type: research

Complementary role of a polymerase chain reaction test in the diagnosis of onychomycosis
ConclusionsThis study demonstrates that PCR increases the sensitivity of detection of dermatophytes in nail specimens. Despite its limitations, the use of PCR can complement direct microscopic examination and fungal cultures to aid clinicians in the diagnosis of suspected dermatophytic onychomycosis. (Source: Australasian Journal of Dermatology)
Source: Australasian Journal of Dermatology - February 21, 2013 Category: Dermatology Authors: Nisha Suyien Chandran, Jiun‐Yit Pan, Zacharias AD Pramono, Hiok‐Hee Tan, Chew‐Swee Seow Tags: Original Research Source Type: research

Complementary role of a polymerase chain reaction test in the diagnosis of onychomycosis.
CONCLUSIONS: This study demonstrates that PCR increases the sensitivity of detection of dermatophytes in nail specimens. Despite its limitations, the use of PCR can complement direct microscopic examination and fungal cultures to aid clinicians in the diagnosis of suspected dermatophytic onychomycosis. PMID: 23425129 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - February 21, 2013 Category: Dermatology Authors: Chandran NS, Pan JY, Pramono ZA, Tan HH, Seow CS Tags: Australas J Dermatol Source Type: research

Nail psoriasis – a treatment challenge
This article presents an overview of different clinical appearances of nail psoriasis, the essential diagnostic assessment before treatment, important differential diagnoses, and published data on treatment options for nail psoriasis. (Source: JDDG)
Source: JDDG - February 20, 2013 Category: Dermatology Authors: Marc A. Radtke, Florian C. Beikert, Matthias Augustin Tags: CME Article Source Type: research

Infected nail plate model made of human hair keratin for evaluating the efficacy of different topical antifungal formulations against Trichophyton rubrum in vitro.
Abstract A novel model of infected nail plate for testing the efficacy of topical antifungal formulations has been developed. This model utilized keratin film made of human hair keratin as a nail plate model. Subsequent to infection by Trichophyton rubrum, the common causative agent of onychomycosis, keratin films as infected nail plate models were treated with selected topical formulations, that is cream, gel, and nail lacquer. Bovine hoof was compared to keratin film. In contrast to the common antifungal susceptibility test, the antifungal drugs tested were applied as ready-to-use formulations because the vehicle...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 16, 2013 Category: Drugs & Pharmacology Authors: Lusiana, Reichl S, Müller-Goymann CC Tags: Eur J Pharm Biopharm Source Type: research

Incidence of onychomycosis among psoriatic patients with nail involvement: a descriptive study
(Source: Mycoses)
Source: Mycoses - February 1, 2013 Category: Research Authors: Daniele Rizzo, Roberta Alaimo, Giovanna Tilotta, Franco Dinotta, Maria Rita Bongiorno Tags: Letter to the editor Source Type: research

Clinical Inquiry: Which oral antifungal works best for toenail onychomycosis?
Abstract Terbinafine, 250 mg daily for 12 to 16 weeks, produces higher clinical cure rates than either pulsed-dose itraconazole or weekly fluconazole. Daily oral dosing is more effective than pulsed-dose terbinafine. PMID: 23405380 [PubMed - in process] (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - February 1, 2013 Category: Practice Management Authors: Volk B, Tiu A, St Anna L Tags: J Fam Pract Source Type: research

Anacor reports positive preliminary results from tavaborole Phase III onychomycosis trial
Biopharmaceutical company Anacor Pharmaceuticals has reported positive preliminary results from the first of two Phase III trials of topical anti-fungal tavaborole, designed to treat onychomycosis. (Source: Drug Development Technology)
Source: Drug Development Technology - January 30, 2013 Category: Pharmaceuticals Source Type: news

Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis.
In conclusion, efinaconazole is a potent antifungal with broad spectrum of activity that may have clinical applications in onychomycosis and other mycoses. PMID: 23318803 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - January 14, 2013 Category: Microbiology Authors: Jo Siu WJ, Tatsumi Y, Senda H, Pillai R, Nakamura T, Sone D, Fothergill A Tags: Antimicrob Agents Chemother Source Type: research

Development of a Novel PCR‐ELISA Assay for the Diagnosis of Trichophyton rubrum Onychomycosis
In conclusion, we have optimized a target gene and DNA extraction method for rapid detection of T. rubrum onychomycosis. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: F. Pankewitz, P. Nenoff, S. Uhrlaß, G. Bezold, I. Winter, Y. Gräser Tags: Original Article Source Type: research

Development of a Novel PCR-ELISA Assay for the Diagnosis of Trichophyton rubrum Onychomycosis.
In conclusion, we have optimized a target gene and DNA extraction method for rapid detection of T. rubrum onychomycosis. PMID: 23301809 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Pankewitz F, Nenoff P, Uhrlaß S, Bezold G, Winter I, Gräser Y Tags: Br J Dermatol Source Type: research

Novel Topical Formulations of Terbinafine-HCl for Treatment of Onychomycosis.
In this study, TBF-HCl loaded liposome and ethosome formulations and also gel form of these formulations were prepared. The formulations were characterized and in-vitro and ex-vivo release studies were performed. Nail characterization studies were also performed to examine the effect of formulations and experimental conditions on nail surface. As a result, all formulations can serve as efficient formulations for ungual application of TBF-HCl. By the way, the results of the accumulation studies suggested that liposome poloxamer gel formulation could be promising system for ungual drug delivery due to the better accumulation...
Source: European Journal of Pharmaceutical Sciences - January 4, 2013 Category: Drugs & Pharmacology Authors: Tanrıverdi ST, Ozer O Tags: Eur J Pharm Sci Source Type: research

Intermittent therapy with terbinafine and nail abrasion for dermatophyte toe onychomycosis: a pilot study
Summary Onychomycosis constitutes up to 50% of all nail disorders. Toenails are generally affected, mostly due to dermatophytes. Terbinafine is the most potent antifungal agent in vitro against dermatophytes. There are few randomised controlled trials using a non‐continuous dose of terbinafine. The aim of this open‐label pilot study was to reduce the total drug amount, the collateral effects and, specially, the costs; albeit maintaining the same efficacy of the standard regimens. Compare the outcomes of two different intermittent regimens with the same total amount of the medication (42 tablets in 6 months). Forty‐...
Source: Mycoses - January 1, 2013 Category: Research Authors: Isabella B. Succi, Andréa R. Bernardes‐Engemann, Rosane Orofino‐Costa Tags: Original article Source Type: research

The Diagnostic Value Of Fungal Fluorescence In Onychomycosis
ConclusionsWe conclude that that fluorescence microscopy can be used as a rapid screening tool for identification of fungi in nail specimens. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - January 1, 2013 Category: Pathology Authors: Munir H. Idriss, Ahmed Khalil, Dirk Elston Tags: Original Article Source Type: research

Onychomycosis Does Not Always Require Systemic Treatment for Cure: A Trial Using Topical Therapy
Abstract Standard teaching dictates that systemic therapy is required for treatment of onychomycosis. It is unknown whether topical antifungal therapy is effective for pediatric nail infections. This prospective, randomized, double‐blind, vehicle‐controlled study was conducted in the Pediatric Dermatology Research Unit at Rady Children's Hospital to determine whether topical antifungal therapy is efficacious for pediatric onychomycosis. Forty patients ages 2 to 16 years with nonmatrix onychomycosis were randomized 1:3 to ciclopirox lacquer or vehicle lacquer. Ciclopirox lacquer or vehicle was applied daily for 32 wee...
Source: Pediatric Dermatology - December 28, 2012 Category: Dermatology Authors: Shiela Fallon Friedlander, Yuin C. Chan, Yiong H. Chan, Lawrence F. Eichenfield Tags: Clinical and Laboratory Investigation Source Type: research

Antifungal Activity of 10 Guadeloupean Plants
Screening of the antifungal activities of ten Guadeloupean plants was undertaken to find new extracts and formulations against superficial mycoses such as onychomycosis, athlete's foot, Pityriasis versicolor, as well as the deep fungal infection Pneumocystis pneumonia. For the first time, the CMI of these plant extracts [cyclohexane, ethanol and ethanol/water (1:1, v/v)] was determined against five dermatophytes, five Candida species, Scytalidium dimidiatum, a Malassezia sp. strain and Pneumocystis carinii. Cytotoxicity tests of the most active extracts were also performed on an HaCat keratinocyte cell line. Results sugges...
Source: Phytotherapy Research - December 27, 2012 Category: Biochemistry Authors: Murielle Biabiany, Vincent Roumy, Thierry Hennebelle, Nadine François, Boualem Sendid, Muriel Pottier, El Moukhtar Aliouat, Isabelle Rouaud, Françoise Lohézic‐Le Dévéhat, Henry Joseph, Paul Bourgeois, Sevser Sahpaz, François Bailleul Tags: Research Article Source Type: research

Systemic Antifungals to Treat Onychomycosis in Children: A Systematic Review
In conclusion, based on the little information available on onychomycosis in children, systemic antifungal therapies in children are safe and cure rates are similar to the rates achieved in adults. (Source: Pediatric Dermatology)
Source: Pediatric Dermatology - December 26, 2012 Category: Dermatology Authors: Aditya K Gupta, Maryse Paquet Tags: Review Article Source Type: research

Association between onychodystrophy and human T-lymphotropic virus type 1 infection
Conclusions: There is an independent association between HTLV-1 infection and onychodystrophy. Patients with an HTLV-1 infection might have a higher risk for onychomycosis given the abnormal nail plate and a decreased T-cell-mediated immunologic response. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - December 13, 2012 Category: Infectious Diseases Authors: Erick F. Mayer, Fanny Ita, Elsa Gonzalez, Kristien Verdonck, Francisco Bravo, Daniel Clark, Eduardo Gotuzzo Tags: Original Reports Source Type: research

Efinaconazole effective for onychomycosis
Once daily topical efinaconazole may be a reasonable alternative to treating onychomycosis, according to results of a recent study. (Source: Modern Medicine)
Source: Modern Medicine - December 5, 2012 Category: Journals (General) Source Type: news

Update: medical treatment of onychomycosis
Abstract The diagnosis of onychomycosis should be made clinically and mycologically: clinically, by one of seven subtypes of onychomycosis, and mycologically, by evidence of dermatophytes or verified presence of molds and/or yeasts. Dermatophytes are usually considered as pathogens, whereas non‐dermatophyte molds and yeasts are saprophytes. Basic anamnesis and close inspection should be performed to eliminate combined diseases (e.g., onychomycosis and trauma). The gold standard treatment for onychomycosis is basically systemic. Combination with topical agents, such as nail lacquer and/or chemical nail avulsion, produces ...
Source: Dermatologic Therapy - December 4, 2012 Category: Dermatology Authors: Avner Shemer Tags: Invited Article Source Type: research

Medical devices for the treatment of onychomycosis
Abstract Device‐based therapies are the most rapidly expanding area of onychomycosis treatment. Traditional pharmacotherapy of onychomycosis has a low to moderate efficacy and is associated with adverse reactions and drug interactions that limit its use in many patients. These new therapies include laser systems, photodynamic therapy, iontophoresis, and ultrasound. Device‐based therapies are procedures conducted in the clinic by a trained professional, which mitigates the requirement for long‐term patient compliance. In addition, the drug component of these therapies is topical, preventing the adverse events associat...
Source: Dermatologic Therapy - December 4, 2012 Category: Dermatology Authors: Aditya K. Gupta, Fiona C. Simpson Tags: Invited Article Source Type: research

Update: nail unit dermatopathology
Abstract Nail unit dermatopathology is a growing field filled with many challenges. Many advances in this field have been made in the last 5 years. This review article provides an update on new information and studies published in that period of time. We divided these works into different sections, including clinical and pathologic challenges in diagnosis and treatment of nail disorders, nail unit biopsy and processing techniques, normal nail unit histology, nail plate structural and growth pathology, metabolic disease, inflammatory conditions, onychomycosis, benign growths, malignant growths, and dyschromias. Specific hig...
Source: Dermatologic Therapy - December 4, 2012 Category: Dermatology Authors: Campbell L. Stewart, Adam I. Rubin Tags: Invited Article Source Type: research

Horizon scanning: Efinaconazole 10% solution in the treatment of toenail onychomycosis - results from two phase III trials
Source: Journal of the American Academy of Dermatology Area: News The Journal of the American Academy of Dermatology has published the results of two phase III trials evaluating efinaconazole 10% solution (efinaconazole), for distal lateral subungual onychomycosis. Two identical, multicentre, double-blind, vehicle-controlled studies were conducted in patients with toenail distal lateral subungual onychomycosis (20%-50% clinical involvement [study 1: N = 870, study 2: N = 785]). Patients were randomized (3:1) to efinaconazole or vehicle, once daily for 48 weeks, with 4-week post-treatment follow-up. The primary ...
Source: NeLM - News - November 27, 2012 Category: Drugs & Pharmacology Source Type: news

Device-Based Therapies for Onychomycosis TreatmentDevice-Based Therapies for Onychomycosis Treatment
Device-based therapies such as lasers, photodynamic therapy, iontophoresis, and ultrasound are promising solutions for the treatment of onychomycosis. Skin Therapy Letter (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 26, 2012 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Laser and light therapy for onychomycosis: a systematic review
Abstract More than just a cosmetic concern, onychomycosis is a prevalent and extremely difficult condition to treat. In older and diabetic populations, severe onychomycosis may possibly serve as a nidus for infection, and other more serious complications may ensue. Many treatment modalities for the treatment of onychomycosis have been studied, including topical lacquers and ointments, oral antifungals, surgical and chemical nail avulsion, and lasers. Due to their minimally invasive nature and potential to restore clear nail growth with relatively few sessions, lasers have become a popular option in the treat...
Source: Lasers in Medical Science - November 25, 2012 Category: Laser Surgery Tags: Lasers in Medical Science Source Type: research

Efinaconazole 10% solution in the treatment of toenail onychomycosis: Two phase III multicenter, randomized, double-blind studies
Background: Onychomycosis is a common nail infection, often resulting in nail plate damage and deformity. Topical lacquer treatments have negligible efficacy. Oral treatments, although more efficacious, are limited by drug interactions and potential hepatotoxicity.Objective: We investigated the safety and efficacy of efinaconazole 10% solution (efinaconazole), the first triazole antifungal developed for distal lateral subungual onychomycosis.Methods: Two identical, multicenter, randomized, double-blind, vehicle-controlled studies were conducted in patients with toenail distal lateral subungual onychomycosis (20%-50% clinic...
Source: Journal of the American Academy of Dermatology - November 22, 2012 Category: Dermatology Authors: Boni E. Elewski, Phoebe Rich, Richard Pollak, David M. Pariser, Shinichi Watanabe, Hisato Senda, Chikara Ieda, Kathleen Smith, Radhakrishnan Pillai, Tage Ramakrishna, Jason T. Olin Tags: Original Articles Source Type: research

Onychomycosis in Cameroon: a clinical and epidemiological study among dermatological patients
Conclusions This is the first investigation dealing with onychomycosis in Cameroon. These data may be useful for future research and in the development of preventive and educational strategies. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - November 21, 2012 Category: Dermatology Authors: Salvador Nkondjo Minkoumou, Valentina Fabrizi, Manuela Papini Tags: Tropical medicine rounds Source Type: research

Sprucing up treatment for fungal nail infection
A lacquer containing resin from the Norway spruce shows promise as a treatment for onychomycosis, suggest results from an exploratory study. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - November 9, 2012 Category: Dermatology Source Type: news

Sprucing up treatment for fungal nail infection
A lacquer containing resin from the Norway spruce shows promise as a treatment for onychomycosis, suggest results from an exploratory study. (Source: MedWire News - Infectious Diseases)
Source: MedWire News - Infectious Diseases - November 9, 2012 Category: Infectious Diseases Source Type: news

PinPointe FootLaser Surpasses 100,000 Treatments For Onychomycosis
NuvoLase Inc. announced today more then 100,000 procedures have now been performed with the PinPointe FootLaser worldwide, more than many of the other light-based options combined (Source: Medical Design Online News)
Source: Medical Design Online News - November 5, 2012 Category: Medical Equipment Source Type: news

An in vitro study of the photodynamic effect of rose bengal on trichophyton rubrum
Abstract Onychomycosis, a fungal infection of the finger or toenails, is predominantly caused by Trichophyton rubrum. Treatment is difficult due to high recurrence rates and problems with treatment compliance. For these reasons, alternative therapies are needed. Here we describe the photoactivation of Rose Bengal (RB) using a green laser (λ = 532 nm) at fluences of 68, 133 and 228 J/cm2, and assess its fungicidal activity on T. rubrum spore suspensions. A 140 µM RB solution was able to induce a fungicidal effect on T. rubrum when photosensitized with the fluence of 228 J/cm2. RB photosensitization using a green laser pro...
Source: Journal of Biophotonics - November 2, 2012 Category: Physics Authors: Leah Cronin, Michelle Moffitt, Damia Mawad, Oliver C. Morton, Antonio Lauto, Colin Stack Tags: Full Article Source Type: research

Natural coniferous resin lacquer in treatment of toenail onychomycosis: an observational study
Summary In in vitro tests, natural coniferous resin from the Norway spruce (Picea abies) is strongly antifungal. In this observational study, we tested the clinical effectiveness of a lacquer composed of spruce resin for topical treatment of onychomycosis. Thirty‐seven patients with clinical diagnosis of onychomycosis were enrolled into the study. All patients used topical resin lacquer treatment daily for 9 months. A mycological culture and potassium hydroxide (KOH) stain were done from nail samples in the beginning and in the end of the study. Treatment was considered effective, if a mycological culture was negative ...
Source: Mycoses - November 1, 2012 Category: Research Authors: Pentti Sipponen, Arno Sipponen, Jouni Lohi, Marjo Soini, Riikka Tapanainen, Janne J. Jokinen Tags: Original article Source Type: research

Onychomycosis in Immunosuppressed Children Receiving Chemotherapy
Abstract Onychomycosis in children has a low incidence worldwide; certain conditions such as immunosuppression have been described as risk factors for it. We studied 72 children receiving chemotherapy for different neoplasms to determine the frequency of onychomycosis. Only one patient had white superficial onychomycosis from Trichophyton rubrum, a frequency of 1.3%, not different from that reported in healthy patients. (Source: Pediatric Dermatology)
Source: Pediatric Dermatology - October 29, 2012 Category: Dermatology Authors: Maria Teresa García Romero, Enrique L. Aguilar, Roberto Arenas Tags: Brief Report Source Type: research

Clinical and mycological features of onychomycosis in central Tunisia: a 22 years retrospective study (1986–2007)
The objective of this study was to determine the prevalence, the clinical and mycological characteristics of onychomycosis in central Tunisia. It is a retrospective study performed over a 22‐year period (1986–2007). It included 7151 patients (4709 women and 2442 men) with suspected fingernails and/or toenails onychomycosis. The patients were referred to the Mycology‐Parasitology Laboratory of Farhat Hached hospital in Sousse for mycological examination. Both direct microscopy and culture of the nail material were performed to diagnose and identify the causative fungal species. Onychomycosis was confirmed in 78.6% of ...
Source: Mycoses - October 26, 2012 Category: Research Authors: I. Dhib, A. Fathallah, A. Yaacoub, R. Zemni, R. Gaha, M. B. Said Tags: Original article Source Type: research

Apricus Biosciences Announces Intent to File NDS for MycoVa(TM) in Canada
SAN DIEGO, Oct. 1, 2012 (GLOBE NEWSWIRE) -- Apricus Biosciences, Inc. ("Apricus Bio" or the "Company") (Nasdaq:APRI) (http://www.apricusbio.com) announced today its intent to file a New Drug Submission ("NDS") in Canada for MycoVa(tm), the Company's topical treatment for onychomycosis. (Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - October 1, 2012 Category: Pharmaceuticals Source Type: news