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Community-acquired methicillin-resistant <i>Staphylococcus aureus</i> pyomyositis with myelitis: A rare occurrence with diverse presentationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kulkarni Girish Baburao, Pal P K, Veena Kumari H B, Goyal M, Kovoor J.M.E, Nadig Savitha, Arakere GayathriNeurology India 2009 57(5):653-656Staphylococcus aureus is the most common bacterial pathogen implicated in pyomyositis. There are increasing reports of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections. The present case report brings out the diverse clinical manifestations of MRSA infection in the form of paraspinal pyomyositis, myelitis, spinal osteomyelitis, and pneumonia. Molecular typing of the organism confirmed the diagnosis. Patient was successfully treated with vancomycin and ...
Source: Neurology India - November 20, 2009 Category: Neurology Authors: Kulkarni Girish Baburao, Pal P K, Veena Kumari H B, Goyal M, Kovoor J.M.E, Nadig Savitha, Arakere Gayathri Source Type: journals

RIA: One Community's ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Reamer Irrigator Aspirator (RIA) has three main indications in our community trauma practice. The most common indication for RIA is harvesting of autololgous bone graft from the femur for nonstructural bone graft. The second most common indication is for irrigation and debridement of intramedullary osteomyelitis. The final indication for RIA is for acute nailing of femoral shaft fractures in patients with multiple long bone fractures with or without pulmonary injury. If one pays careful attention to the details of the technique, RIA is a safe and effective method of harvesting autologous bone graft with minimal morbidi...
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Christopher G. Finkemeier, Rafael Neiman, Domingo Hallare Source Type: journals

In Vitro and In Vivo Efficacy of Teicoplanin-loaded Calcium Sulphate for the Treatment of Chronic MRSA Osteomyelitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In vitro and in vivo therapeutic efficacy of teicoplanin-loaded calcium sulphate (TCS, 10 wt% teicoplanin) was investigated in a rabbit model of chronic methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. The in vitro elution characteristics of teicoplanin from TCS pellets were realized by carrying out an evaluation on release kinetics, recovery rate and antibacterial activity of the released teicoplanin. Chronic osteomyelitis was induced by inoculating 10(7) cfu of MRSA strain into the tibial cavity of rabbits. After 3 weeks, the animals were treated by debridement, followed by implantation of TCS pellet...
Source: Antimicrobial Agents and Chemotherapy - November 16, 2009 Category: Microbiology Authors: Jia WT, Luo SH, Zhang CQ, Wang JQ Tags: Antimicrob Agents Chemother Source Type: journals

Italian Guidelines for the Diagnosis and Infectious Disease Management of Osteomyelitis and Prosthetic Joint Infections in AdultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article presents the recommendations for the diagnosis and management of osteomyelitis and prosthetic joint infections in adults developed by Bone and Joint Infections Committee for the Italian Society of Infectious and Tropical Diseases. It contains data published through to November 2007. An evidence-based scoring system that is used by the Infectious Diseases Society of America was applied to treatment recommendations. Content Type Journal ArticleCategory ReviewDOI 10.1007/s15010-009-8269-2Authors S. Esposito, Seconda Università di Napoli Dipartimento Malattie Infettive Naples ItalyS. Leone, U.O.C. Malatti...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review summarizes the in vitro and animal model data available on antibiotic combinations with daptomycin. The majority of studies focus on the clinically relevant combinations of daptomycin with rifampicin or with gentamicin. These studies demonstrate that daptomycin does not adversely affect the activity of other antimicrobial agents that may be administered concomitantly. Overall, additive or indifferent effects with daptomycin combinations were observed; however, synergy was observed for certain isolates of vancomycin-resistant enterococci when exposed to daptomycin and rifampicin. Unexpected synergy was demonstra...
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Steenbergen, J. N., Mohr, J. F., Thorne, G. M. Tags: Review Source Type: journals

OsteomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: OsteomyelitisCategory: Diseases and ConditionsCreated: 11/6/2009 5:06:00 PMLast Editorial Review: 11/6/2009 5:06:05 PM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - November 6, 2009 Category: Anesthesiology Source Type: consumer

OsteomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: OsteomyelitisCategory: Diseases and ConditionsCreated: 11/6/2009 5:06:00 PMLast Editorial Review: 11/6/2009 5:06:05 PM (Source: MedicineNet Senior Health General)
Source: MedicineNet Senior Health General - November 6, 2009 Category: Geriatrics Source Type: consumer

OsteomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: OsteomyelitisCategory: Diseases and ConditionsCreated: 11/6/2009 5:06:00 PMLast Editorial Review: 11/6/2009 5:06:05 PM (Source: MedicineNet Womens Health General)
Source: MedicineNet Womens Health General - November 6, 2009 Category: OBGYN Source Type: consumer

Septic arthritis of the knee joint secondary to adjacent chronic osteomyelitis of the femur in an adultEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The present report describes a case of septic knee arthritis secondary to reactivated chronic osteomyelitis. The osteolytic lesion observed on the initial radiographs resulted in further imaging studies including CT and MRI, which confirmed the diagnosis. Based on the patient’s history, physical findings and imaging studies, we performed open debridement rather than arthroscopic surgery in order to treat the infected intraarticular knee joint and ream the femur intramedullary canal. Additionally, an antibiotic-impregnated cement rod was inserted into the medullary cavity to fill the dead space and...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - November 5, 2009 Category: Orthopaedics Tags: Knee Surgery, Sports Traumatology, Arthroscopy Source Type: journals

Vertebral osteomyelitis with a rare etiology diagnosed by fine-needle aspiration cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report one such case of vertebral osteomyelitis due to Aspergillus diagnosed by FNAC in a well-controlled diabetic patient who presented with nonspecific symptoms and in whom a clinical and radiological diagnosis of Pott's spine was considered. The present case stresses the importance of early cytologic diagnosis of vertebral Aspergillus osteomyelitis, which in conjunction with appropriate timely medical and surgical treatment, offers good recovery without much sequelae or threat to life. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: BN Nandeesh, Usha Kini, Betty Alexander Source Type: journals

Can procalcitonin measurement help the diagnosis of osteomyelitis and septic arthritis? A prospective trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: PCT is not a good screening test for identifying skeletal infection in children. Larger studies are needed to evaluate still more the place of PCT measurements in the diagnosis of osteomyelitis and septic arthritis. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 4, 2009 Category: Pediatrics Authors: Sabine FaeschBogdan CojocaruCarole HennequinStephanie PannierChristophe GlorionBernard LacourGerard Cheron Source Type: journals

Septic Arthritis in Adults with Sickle Cell Disease Often is Associated with Osteomyelitis or Osteonecrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The incidence of septic arthritis in adults with SCD is low, but often is associated with osteomyelitis or osteonecrosis. LEVEL OF EVIDENCE: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence. PMID: 19885711 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - November 3, 2009 Category: Orthopaedics Authors: Hernigou P, Daltro G, Flouzat-Lachaniette CH, Roussignol X, Poignard A Tags: Clin Orthop Relat Res Source Type: journals

Vacuum-assisted closure and bilateral pectoralis muscle flaps for different stages of mediastinitis after cardiac surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Early BPMMF is an effective surgical treatment for DSWI in patients with an unstable sternum and osteomyelitis. VAC may be considered for patients without osteomyelitis but a stable sternum, or as adjuvant therapy in patients with comorbidity. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-008-3982-5Authors Zeynep Eyileten, University of Ankara School of Medicine Department of Cardiovascular Surgery, Heart Centre Dikimevi, Ankara 06340 TurkeyAhmet Ruchan Akar, University of Ankara School of Medicine Department of Cardiovascular Surgery, Heart Centre Dikimevi, Ankara...
Source: Surgery Today - November 2, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Infectious and Inflammatory DisordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteomyelitis and inflammatory arthritis affect many children. In this article, the authors describe clinical, pathophysiologic, and imaging characteristics of common (and a few not-so-common) conditions in these categories. Emphasis is placed on MR imaging characteristics, but the article discusses other imaging modalities and clinical evaluation when appropriate. Having a thorough understanding of the pathophysiology and imaging characteristics of these disease processes helps us choose the best radiologic study to answer the clinical questions. (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - November 1, 2009 Category: Radiology Authors: Sumit Pruthi, Mahesh M. Thapa Source Type: journals

Primary bone lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary bone lymphomas are rare, even though secondary involvement of the bone marrow is a common event in systemic lymphomas. Most primary bone lymphomas are primary bone diffuse large B-cell lymphomas (PBDLBCLs) with a rare occurrence of follicular, marginal zone, anaplastic large cell, Hodgkin, and T-cell lymphomas. The PBDLBCL affects the middle-aged to elderly population, with a slight predominance in men. The patients present with bone pain, palpable mass, fractures, or neurologic symptoms. The metaphysis of bones is a common location of PBDLBCL. Morphologically, the lymphoma consists of a polymorphous mixture of...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Bhagavathi S, Fu K Tags: Arch Pathol Lab Med Source Type: journals

Imported melioidosis, Israel, 2008.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2008, melioidosis was diagnosed in an agricultural worker from Thailand in the southern Jordan Valley in Israel. He had newly diagnosed diabetes mellitus, fever, multiple abscesses, and osteomyelitis. Burkholderia pseudomallei was isolated from urine and blood. Four of 10 laboratory staff members exposed to the organism received chemoprophylaxis, 3 of whom had adverse events. PMID: 19891871 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - November 1, 2009 Category: Infectious Diseases Authors: Cahn A, Koslowsky B, Nir-Paz R, Temper V, Hiller N, Karlinsky A, Gur I, Hidalgo-Grass C, Heyman SN, Moses AE, Block C Tags: Emerg Infect Dis Source Type: journals

Bartonella henselae and pyogranulomatous lymphadenitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bartonella henselae is the cause of Cat Scratch Disease (CSD), a typically self-limiting, benign regional lymphadenopathy. CSD is often accompanied by fever, malaise, and fatigue in immunocompetent humans. Atypical CSD, complicated by Parinaud's oculoglandular syndrome, retinitis, glomerulonephritis, endocarditis, granulomatous hepatitis, hemolytic anemia, and osteomyelitis, develops in 5% to 25% of cases. Bartonella henselae causes several granulomatous syndromes in humans; however, evidence of B henselae as a causative agent of granulomatous disease in dogs remains circumstantial. (Source: Advances in Small Animal Medicine and Surgery)
Source: Advances in Small Animal Medicine and Surgery - November 1, 2009 Category: Veterinary Research Tags: Clinical Pathology Source Type: journals

Infectious and inflammatory disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteomyelitis and inflammatory arthritis affect many children. In this article, the authors describe clinical, pathophysiologic, and imaging characteristics of common (and a few not-so-common) conditions in these categories. Emphasis is placed on MR imaging characteristics, but the article discusses other imaging modalities and clinical evaluation when appropriate. Having a thorough understanding of the pathophysiology and imaging characteristics of these disease processes helps us choose the best radiologic study to answer the clinical questions. PMID: 19895964 [PubMed - in process] (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - November 1, 2009 Category: Radiology Authors: Pruthi S, Thapa MM Tags: Radiol Clin North Am Source Type: journals

Antineoplastics: Osteonecrosis and osteomyelitis (first report with epirubicin): case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Median Facial Cleft with a Frontoethmoidal Encephalocele Treated with Craniofacial Bipartition and Free Radial Forearm Flap: A Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a patient with a median facial cleft with a frontoethmoidal encephalocele, hypertelorism, hydrocephalus, and cerebrospinal fluid (CSF) leakage referred to our department due to numerous complications after previous surgical treatments. An 8-year-old girl, born with median cleft syndrome, underwent neurosurgical repair of the encephalocele at another hospital and cleft lip/palate repair later in the same year. Her hydrocephalus was treated with a ventriculoperitoneal shunt, but she underwent numerous shunt revisions due to recurrent intracerebral infections. In 2008, she was rehospitalized due to a gram-negative...
Source: Skull Base - October 30, 2009 Category: ENT & OMF Tags: CASE REPORT Source Type: journals

Two-stage revision surgery for hip prosthesis infection using antibiotic-loaded porous hydroxyapatite blocksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here a modification of this delivery system applied for the first stage of two-stage reconstruction surgery against infected hip prosthesis. Patients and methods Eight consecutive patients who developed hip prosthesis infection underwent two-stage revision total hip arthroplasty (THA) using antibiotic-loaded porous HA blocks prepared by the vacuum method. Thorough debridement and insertion of antibiotic-loaded HA blocks was performed in the first stage, followed by conversion to THA after eradication of infection in the second stage. Results The mean interval between the sta...
Source: Archives of Orthopaedic and Trauma Surgery - October 29, 2009 Category: Orthopaedics Tags: Archives of Orthopaedic and Trauma Surgery Source Type: journals

Osteonecrosis of the jaw (ONJ) in chronically treated patients with bisphosphonates (BPS)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report our experience in patients under BPs chronic treatment who were referred to us since 2007 by Buenos Aires suburban hospitals to the Dentomaxillofacial Department, School of Dentistry, Buenos Aires University. One man and fifteen women (62.75±4 years old) with ONJ diagnosis under BPs treatment administered during at least 6 months were evaluated. A total of 12 patients were treated with one BPs (alendronate: 56.25%; pamidronate: 12.50%; zolendronate: 25%; risendronate: 6.25%); the remaining were treated with two BPs: pamidronate/zolendronate, 1; alendronate/zolendronate, 2; and alendronate/pamidronate, 1. Two pa...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: S. Picardo, G.G. Pellegrini, E. Rey, S.N. Zeni Source Type: journals

Cefoperazone sodium impregnated polycaprolactone composite implant for osteomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anand A, Pundir R, Pandian C S, Saraf S, Gupta HIndian Journal of Pharmaceutical Sciences 2009 71(4):377-381The use of local antibiotics from a biodegradable implant for chronic osteomyelitis is an attractive alternative. The implant delivers high antibiotic concentration at tissue levels, obliterates dead space, aids bone repair and does not need to be removed. The purpose of this paper is to develop and evaluate a calcium sulphate and polycaprolactone based composite biodegradable implantable delivery system of cefoperazone sodium. Implants were prepared by modified fabrication technique to avoid solvent use. Interaction...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Anand A, Pundir R, Pandian C S, Saraf S, Gupta H Source Type: journals

[Marjolin's ulcer : Malignant transformation of a crural ulcer due to posttraumatic chronic osteomyelitis.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on the case of an 81-year-old female patient who developed a squamous cell carcinoma in a long-lasting therapy-resistant crural ulcer of the lower leg due to posttraumatic chronic osteomyelitis. Eventually the lower leg had to be amputated because of massive destruction of soft tissue and the tibia bone. Based on the desolate wound conditions plastic reconstruction by a pivoted muscle flap and surgical covering with mesh graft plastic was also necessary.The amputation stump had completely healed 6 months after surgery and the patient is fitted with an artificial limb ensuring independent mobility even outside the...
Source: Der Unfallchirurg - October 28, 2009 Category: Orthopaedics Authors: Bula P, Bula-Sternberg J, Wollina U, Haroske G, Bonnaire F Tags: Unfallchirurg Source Type: journals

European CHMP issues positive opinion on besilesomab (Scintimun®)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: EMEA Area: News The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending the granting of a marketing authorisation for besilesomab (Scintimun®), a radiopharmaceutical intended for use in scintigraphic imaging, in conjunction with other appropriate imaging modalities, for determining the location of inflammation/infection in peripheral bone in adults with suspected osteomyelitis. (Source: NeLM - Rheumatology)
Source: NeLM - Rheumatology - October 22, 2009 Category: Rheumatology Source Type: organizations

An unusual etiology of osteomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of 3-year-child with varicella associated with pandiaphysal osteomyelitis caused by streptococcus type A β hemolytic. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00590-009-0564-1Authors Hichem Mnif, Monastir Fattouma-Bourguiba Teaching Hospital Department of Orthopaedic Surgery Monastir TunisiaMakram Zrig, Monastir Fattouma-Bourguiba Teaching Hospital Department of Orthopaedic Surgery Monastir TunisiaKarim Amara, Monastir Fattouma-Bourguiba Teaching Hospital Department of Orthopaedic Surgery Monastir TunisiaSabeur Hammami, Monastir Fattouma-Bourguiba Teaching Hospital Department o...
Source: European Journal of Orthopaedic Surgery & Traumatology - October 21, 2009 Category: Orthopaedics Tags: European Journal of Orthopaedic Surgery & Traumatology Source Type: journals

A rare radiological appearance of lumbar tuberculous vertebral osteomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes an unusual case with a very interesting radiological appearance of spinal TB. A 30-year-old man presented with dull, progressive back pain. Radiological control showed complete destruction of the L4 vertebral body and partial destruction of the L3, as well as extensive bilateral paraspinal soft tissue infection. The patient underwent open biopsy, complete abscess drainage, lumbar spine stabilization and antituberculous chemotherapy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00590-009-0563-2Authors Christiana Savvidou, University of Athens Medical School, Agia Olga Hospital �...
Source: European Journal of Orthopaedic Surgery & Traumatology - October 21, 2009 Category: Orthopaedics Tags: European Journal of Orthopaedic Surgery & Traumatology Source Type: journals

Clinicopathological Profile and Surgical Results of Nonhealing Sinuses and Fistulous Tracts of the Head and Neck RegionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All patients with sinus or fistulous tracts in the head and neck region should be properly assessed and evaluated for proper diagnosis and treatment, to prevent the recurrence and chronicity of these lesions. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - October 20, 2009 Category: ENT & OMF Authors: Nisar A. Chowdri, Shakil Sheikh, Mushtaq A. Gagloo, Fazal Q. Parray, Manzoor A. Sheikh, Fayaz A. Khan Tags: Basic and Patient-Oriented Research Source Type: journals

A Conserved Serine Residue Is Required for the Phosphatidate Phosphatase Activity but Not the Transcriptional Coactivator Functions of Lipin-1 and Lipin-2 [Lipids and Lipoproteins: Metabolism, Regulation, and Signaling]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mammalian lipins (lipin-1, lipin-2, and lipin-3) are Mg2+-dependent phosphatidate phosphatase (PAP) enzymes, which catalyze a key reaction in glycerolipid biosynthesis. Lipin-1 also functions as a transcriptional coactivator in conjunction with members of the peroxisome proliferator-activated receptor family. An S734L mutation in LPIN2 causes Majeed syndrome, a human inflammatory disorder characterized by recurrent osteomyelitis, fever, dyserythropoietic anemia, and cutaneous inflammation. Here we demonstrate that mutation of the equivalent serine in mouse lipin-1 and lipin-2 to leucine or aspartate abolishes PAP activity ...
Source: Journal of Biological Chemistry - October 16, 2009 Category: Chemistry Authors: Donkor, J., Zhang, P., Wong, S., O'Loughlin, L., Dewald, J., Kok, B. P.C., Brindley, D. N., Reue, K. Tags: Lipids and Lipoproteins: Metabolism, Regulation, and Signaling Source Type: journals

Osteopetrosis Complicated by Osteomyelitis of the Maxilla and Mandible: Light and Electron Microscopic FindingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report presents a case of osteopetrosis in a 25-year-old male, which was complicated by the development of osteomyelitis in the maxilla and mandible following traumatic injury and tooth extractions. The osteomyelitis in the mandible was refractory to marginal resection and antibiotic therapy. Partial resection with mandible reconstruction was then carried out. Light and backscattered electron scanning microscopy revealed sclerosis of spongy bone and variations in mineral density of the bone matrix. There was also a prominent periosteal bone formation in regions affected by osteomyelitis. An 18-month follow-up show...
Source: Head and Neck Pathology - October 15, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Diagnostic Performance of FDG-PET, MRI, and Plain Film Radiography (PFR) for the Diagnosis of Osteomyelitis in the Diabetic FootEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion FDG-PET is a highly specific imaging modality for the diagnosis of osteomyelitis in diabetic foot and, therefore, should be considered to be a useful complimentary imaging modality with MRI. In the setting where MRI is contraindicated, the high sensitivity and specificity of FDG-PET justifies its use after a negative or inconclusive PFR to aid an accurate diagnosis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0268-2Authors Asad Nawaz, Department of Radiology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania Division of...
Source: Molecular Imaging and Biology - October 9, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Very Late‐Onset Group B Streptococcus Meningitis, Sepsis, and Systemic Shigellosis due to Interleukin‐1 Receptor–Associated Kinase‐4 DeficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a child with very late‐onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin‐1β or lipopolysaccharide. Sequencing of the interleukin‐1 receptor–associated kinase‐4 gene revealed 2 novel mutations. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - October 8, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals

Antibiotics Control SAPHO Syndrome, but Symptoms Recur When Therapy StopsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although SAPHO syndrome - which stands for synovitis, acne, pustulosis, hyperostosis, and osteomyelitis - responds to antibiotics, discontinuing the medication leads to relapse, German researchers report in the September 21st online issue of Arthritis Research and Therapy. Reuters Health Information (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - October 8, 2009 Category: Rheumatology Tags: Rheumatology Source Type: info

Tuberculous vertebral osteomyelitis: Findings of a 10-year review of experience in a UK centreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest Luzzati et al's recent review of spinal infections presenting to two Italian hospitals over an 11-year period. They presented data on 27 cases of spinal tuberculosis (TB), and concluded that tuberculous vertebral osteomyelitis was associated with significant diagnostic delay, need for operative intervention and ongoing back pain after completion of therapy. They found that most cases of spinal TB occurred in non-foreign-born individuals, although further data on ethnicity were not given. We have recently reviewed cases of tuberculous vertebral osteomyelitis in Sheffield, United Kingdom over a 10-year ...
Source: Journal of Infection - October 6, 2009 Category: Infectious Diseases Authors: Polly C. Kenyon, Ann L.N. Chapman Tags: Letters to the Editor Source Type: journals

New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar pustulosis, severe acne, and hidradenitis suppurativa. Despite recent advances in our understanding of the epidemiologic, pathophysiologic, and immunogenetic mechanisms involved in SAPHO syndrome, etiopathogenesis remains poorly understood. Propioni...
Source: Current Rheumatology Reports - October 6, 2009 Category: Rheumatology Tags: Current Rheumatology Reports Source Type: journals

What is the Appropriate Treatment for a Pedal Puncture Wound?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Ciprofloxacin and other fluoroquinolones have demonstrated cartilage and joint toxicity when administered to immature laboratory animals. Therefore health care providers have been reluctant to use fluoroquinolones in young children and voluntarily have avoided them. However in 2002, more than 182,000 courses of fluoroquinolones were administered to children. Research data is limited but the pediatric safety profile appears to be similar to the adult safety profile. Current indications for fluoroquinolones include complicated urinary tract infections, treatment of opportunistic infections in immunocompromised pat...
Source: PediatricEducation.org - October 5, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info

The mandibulotomy: Friend or foe? Safety outcomes and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine the safety outcomes of a unique mandibulotomy technique and to compare results to the world literature.Retrospective review of a tertiary care head and neck cancer practice.A total of 220 consecutive lip-splitting mandibulotomy access cases from 1998 to 2006 were identified in the University of Alberta's prospective head and neck surgery database and reviewed with follow-up to June 2009. Uniform surgical technique consisting of a lower lip-splitting incision, incisor extraction, a paramedian stair-step osteotomy, and combination fixation with direct interosseous wires and a compression miniplate was utilized f...
Source: The Laryngoscope - October 4, 2009 Category: ENT & OMF Authors: Peter T. Dziegielewski, Alex M. Mlynarek, John Dimitry, Jeffrey R. Harris, Hadi Seikaly Source Type: journals

Nonbacterial osteitis: a clinical, histopathological, and imaging study with a proposal for protocol-based management of patients with this diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions On the basis of our findings, we propose using a patient questionnaire and protocol for investigating and managing patients who present with NBO to orthopedic surgeons. We predict that this will benefit patients with this disorder by improving our knowledge of the presenting signs and symptoms and related disorders, rationalizing the therapeutic approach, and allowing us to learn about the natural history of the disease. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00776-009-1381-4Authors Panagiotis D. Gikas, Bone Tumour Unit, Royal National Orthopaedic Hospital Stanm...
Source: Journal of Orthopaedic Science - October 3, 2009 Category: Orthopaedics Tags: Journal of Orthopaedic Science Source Type: journals

Fight Diabetic Non-Healing Wounds Lying DownEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
October 2, 2009 (Newswise) - More than 18-million people in the United States, or 6.3% of the population, have diabetes, according to the American Diabetes Association. Unfortunately, when someone becomes diabetic, chronic non-healing wounds often develop, most often in the legs and feet. These wounds can be uncomfortable and even life-threatening. There are many types of treatments. One of the most painless and successful is hyperbaric oxygen therapy (HBOT). Hyperbaric oxygen therapy is a specialized medical treatment inside a pressurized chamber, in which a patient breathes 100 percent oxygen at greater than normal...
Source: Diabetes News from dLife.com - October 1, 2009 Category: Consumer Health News Authors: dlife Source Type: info

Nontuberculous Mycobacteria Infection and Tumor Necrosis Factor-OC Antagonists.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report pulmonary M. haemophilum infection in a woman who had been immunosuppressed by tumor necrosis factor-oc antagonist (TNF-ocA) (adalimumab) treatment for rheumatoid arthritis. PMID: 19861085 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 1, 2009 Category: Infectious Diseases Authors: Swart RM, van Ingen J, van Soolingen D, Slingerland R, Hendriks WD, den Hollander JG Tags: Emerg Infect Dis Source Type: journals

Mycobacterium chelonae infections involving the head and neck.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Mycobacterium chelonae should be considered in cases of abscesses that persist despite broad-spectrum intravenous antibiotics, and in cases of maxillary sinusitis with bony involvement that do not respond to traditional treatment methods. PMID: 19894399 [PubMed - in process] (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - October 1, 2009 Category: ENT & OMF Authors: Mullin D, Jothi S, Healy D Tags: Ann Otol Rhinol Laryngol Source Type: journals

Aortic Endograft Infection with Aortoduodenal Fistula Associated with Adjacent Vertebral Body Mycobacterial Osteomyelitis (Pott's Disease)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aortoenteric fistulae (AEF) are a rare complication of infrarenal abdominal aortic aneurysm (IAAA) repair. These fistulae, which occur in (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - September 28, 2009 Category: Surgery Authors: B. Solomon, G. Plitas, S. Bauer, L. Rousou, G. Jacobowitz Tags: EVS abstracts Source Type: journals

Serratia marcescens: A case history to illustrate the value of radiographer history taking in the face of poor health professional communicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The radiographer is often the only point of contact that a patient may have with the Medical Imaging team. Assessment of the patient by the radiographer is a role that has tacitly and historically occurred in most practice, though in this age of litigation and heavy workloads it is prudent to suggest that a formulated approach should be adopted. This may occur in undergraduate education and be developed in the postgraduate forum such that good imaging is performed and appropriate extra information reaches the radiologist that may often be lacking in the referral historical details. This case based article uses an...
Source: Radiography - September 28, 2009 Category: Radiology Authors: Susan Hannah, Jonathan McConnell Tags: On-line Only Articles Source Type: journals

Cellular magnetic resonance imaging for the differentiation of infectious and degenerative vertebral disorders: Preliminary resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate macrophage imaging using the ability of superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI) to differentiate infectious vertebral osteomyelitis and degenerative disk-related inflammatory endplates. The in vivo demonstration of the different distribution of macrophages in those two disorders may allow a more accurate characterization of vertebral endplate abnormalities than classical extracellular MR changes.In 12 patients with endplate abnormalities (six cases of bacteriologically proven spondylodiscitis, six cases of disk degeneration-related endplate changes), two MRI sessions were realized: ...
Source: Journal of Magnetic Resonance Imaging - September 27, 2009 Category: Radiology Authors: Guillaume Bierry, François Jehl, Nathalie Holl, Jean Sibilia, Sébastien Froelich, Pierre Froehlig, Jean-Louis Dietemann, Stéphane Kremer Tags: Technical Notes Source Type: journals

Update in Diagnosis and Treatment of Diabetic Foot InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Foot infections are a major cause of morbidity and mortality in diabetics. Evaluation of diabetic foot infections often requires clinical, radiologic, laboratory, and microbiologic assessment. Osteomyelitis has a profound impact on the prognosis and management of these infections, and diagnosis can be difficult; the gold standard remains bone biopsy. Despite a panoply of studies, the optimal management of diabetic foot infections remains poorly understood. Antibiotics, surgery, rehabilitation and/or off-loading, and glycemic control remain the cornerstones of treatment; alternative therapies remain largely unproven. (Sourc...
Source: Physical Medicine and Rehabilitation Clinics of North America - September 25, 2009 Category: Rehabilitation Authors: Andy O. Miller, Michael Henry Source Type: journals

The accuracy of different imaging techniques in diagnosis of acute hematogenous osteomyelitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our analysis showed that late x-ray is the most valuable radiologic method in the diagnosis of acute hematogenous osteomyelitis, but bone scintigraphy and magnetic resonance imaging are the most valuable tests at the onset of the disease. PMID: 19773621 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 25, 2009 Category: Universities & Medical Training Authors: Malcius D, Jonkus M, Kuprionis G, Maleckas A, Monastyreckiene E, Uktveris R, Rinkevicius S, Barauskas V Tags: Medicina (Kaunas) Source Type: journals

Spread of Squamous Cell Carcinoma From the Thumb to the Small Finger via the Flexor Tendon SheathsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the development of metastatic squamous cell carcinoma at the tip of the small finger following the development of a thumb distal phalanx squamous cell carcinoma caused by chronic osteomyelitis. The spread of hand infections from the flexor tendons of the thumb to the small finger through a tendon sheath connection at the wrist is a well-described phenomenon. The evidence from this case suggests that the spread of the squamous cell carcinoma from the tip of the thumb to the tip of the small finger occurred in a similar fashion. This information is important in understanding how malignant tumors spread in the hand ...
Source: The Journal of Hand Surgery - September 23, 2009 Category: Surgery Authors: Michael A. Rauh, Thomas R. Duquin, Brian E. McGrath, Eugene R. Mindell Tags: Scientific Articles Source Type: journals

Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: interventional studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: For the period of application, the antibiotic therapy seems to have controlled the disease. After antibiotics discontinuation however, disease relapse was observed. SAPHO syndrome thus groups with other chronic inflammatory arthropathies with a need of permanent therapy. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 20, 2009 Category: Rheumatology Authors: Gunter AssmannOlaf KueckTimm KirchhoffHerbert RosenthalJan VoswinkelMichael PfreundschuhHenning ZeidlerAnnette Wagner Source Type: journals

Linezolid-associated optic neuropathy in a patient with ocular sarcoidosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our findings demonstrate that it is important for ophthalmologists as well as physicians and orthopedists to consider the possibility of optic neuropathy caused by long-term use of linezolid. Content Type Journal ArticleCategory Clinical InvestigationDOI 10.1007/s10384-009-0678-3Authors Katsuji Kiuchi, Osaka Saiseikai Izuo Hospital Department of Ophthalmology Osaka JapanMiki Miyashiro, Osaka Saiseikai Izuo Hospital Department of Ophthalmology Osaka JapanChiemi Kitagawa, Osaka Saiseikai Izuo Hospital Department of Ophthalmology Osaka JapanSanae Wada, Osaka Saiseikai Izuo Hospital Department o...
Source: Japanese Journal of Ophthalmology - September 18, 2009 Category: Opthalmology Tags: Japanese Journal of Ophthalmology Source Type: journals