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This page shows you the latest news and research items in this category.

Effects of tramadol on viscero‐visceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - May 24, 2013 Category: Drugs & Pharmacology Authors: Mariangela Lopopolo, Giannapia Affaitati, Alessandra Fabrizio, Francesca Massimini, Domenico Lapenna, Maria Adele Giamberardino, Raffaele Costantini Tags: Original Article Source Type: research

The relationship between sagittal curvature and extensor muscle volume in the lumbar spine.
Abstract A previous modelling study predicted that the forces applied by the extensor muscles to stabilise the lumbar spine would be greater in spines that have a larger sagittal curvature (lordosis). Because the force-generating capacity of a muscle is related to its size, it was hypothesised that the size of the extensor muscles in a subject would be related to the size of their lumbar lordosis. Magnetic resonance imaging (MRI) data were obtained, together with age, height, body mass and back pain status, from 42 female subjects. The volume of the extensor muscles (multifidus and erector spinae) caudal to the mid...
Source: Journal of Anatomy - May 24, 2013 Category: Anatomy Authors: Meakin JR, Fulford J, Seymour R, Welsman JR, Knapp KM Tags: J Anat Source Type: research

Red fingers syndrome in a patient with pseudolymphoma
To the Editor: A 31-year-old woman presented with a 10-year history of erythematous plaques on the face consistent with cutaneous pseudolymphoma. She incidentally was noted to also have dusky discoloration of her distal fingers and hypothenar eminences bilaterally (), but not toes, and without associated pain, numbness, or accentuation in the cold. Onycholysis was noted on several fingernails, but clubbing or periungual telangiectasias were not present. The patient related that the redness was not present at birth and appeared during her adult years before her pseudolymphoma lesions. She also noted that the redness appeare...
Source: Journal of the American Academy of Dermatology - May 24, 2013 Category: Dermatology Authors: Barry Ladizinski, Elise A. Olsen Tags: JAAD Online Source Type: research

Physician Global Assessment (PGA) and Psoriasis Area and Severity Index (PASI): Why do both? A systematic analysis of randomized controlled trials of biologic agents for moderate to severe plaque psoriasis
To the Editor: With great interest we read the publication “Physician Global Assessment (PGA) and Psoriasis Area and Severity Index (PASI): Why do both? A systematic analysis of randomized controlled trials of biologic agents for moderate to severe plaque psoriasis” by Robinson, Kardos, and Kimball. Systematic research on outcomes methodology in psoriasis—such as the study by Robinson et al—is very valuable and may help to standardize the reporting of efficacy in future clinical trials. Standardization of outcome measures is a prerequisite for evidence-based medicine and enables indirect comparisons of different i...
Source: Journal of the American Academy of Dermatology - May 24, 2013 Category: Dermatology Authors: Alexander Nast, Jochen Schmitt Tags: Notes & Comments Source Type: research

Self-perceived changes in oral health-related quality of life after receiving different types of conventional prosthetic treatments: A cohort follow-up study
Conclusions Patients perceived benefits in chewing ability, aesthetics and satisfaction with their mouth after receiving conventional dental prostheses. Clinical significance Conventional prosthetic therapy enhances patients’ overall well-being although it can cause discomfort and chewing dysfunction in more than 20% of subjects. Metal-based removable partial dentures are the most predictable in terms of patient satisfaction. The higher the clinical impairment felt by patients, the higher the increase in OHRQoL after rehabilitation. (Source: Journal of Dentistry)
Source: Journal of Dentistry - May 23, 2013 Category: Dentistry Source Type: research

How Can a Methadone and an Opiate-Positive Immunoassay Result be Reconciled in a Patient Prescribed only OxyContin and Wellbutrin?
This report introduces the complex nature involved in understanding and interpreting urine drug testing (UDT) results in pain patients who are prescribed opioid medications. Laboratory testing examples of UDT results are provided to illustrate the sometimes discordant nature of UDT interpretation. This case study describes one method of approaching cases where laboratory result interpretation in pain clinic patients is essential for medical treatment and management. The case presented in this manuscript illustrates a reconciliation of an opiate positive immunoassay result in a patient who was prescribed only OxyContin and ...
Source: Annals of Clinical and Laboratory Science - May 23, 2013 Category: Laboratory Medicine Authors: Abadie JM Tags: Ann Clin Lab Sci Source Type: research

Intrathecal Transplantation of Neural Stem Cells Appears to Alleviate Neuropathic Pain in Rats Through Release of GDNF.
Abstract The beneficial effect of stem cells on several animal models of neuropathic pain has been recognized recently. However, there have been no studies on the effects of neural stem cell transplantation on neuropathic pain. In the present study, using the rat model of chronic constriction injury of the sciatic nerve, we observed the effect of intrathecal transplantation of extrinsic neural stem cells on the behavior and expression of neurotrophins such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in the spinal dorsal horn and dorsal root ganglia (DRG), and a...
Source: Annals of Clinical and Laboratory Science - May 23, 2013 Category: Laboratory Medicine Authors: Xu Q, Zhang M, Liu J, Li W Tags: Ann Clin Lab Sci Source Type: research

Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease.
Abstract Cardiovascular disease is a leading cause of morbidity and mortality worldwide, encompassing a variety of cardiac and vascular conditions. Transient receptor potential vanilloid (TRPV) channels, specifically TRPV type 1 (TRPV1) and TRPV type 2 (TRPV2), are relatively recently described channels found throughout the body including within and around the cardiovascular system. They are activated by a variety of stimuli including high temperatures, stretch, and pharmacologic and endogenous ligands. The TRPV1 channel has been found to be an important player in the pathway of the detection of chest pain after my...
Source: Translational Research : the journal of laboratory and clinical medicine - May 23, 2013 Category: Laboratory Medicine Authors: Robbins N, Koch SE, Rubinstein J Tags: Transl Res Source Type: research

Single-stage operation for traumatic thoracolumbar fractures with severe dislocation via a posterior approach alone: a case series.
CONCLUSION: Our experience proves that the single-stage posterior approach is safe and biomechanically reliable for treating severe thoracolumbar fractures/dislocations. Therefore, the presented technique is an alternative approach for this rare injury. PMID: 23546901 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - May 23, 2013 Category: Neurosurgery Authors: Xiong W, Li F, Zhang F, Huo X, Chen A Tags: Turk Neurosurg Source Type: research

Ketamine in pain management.
Abstract For ketamine's fiftieth birthday, a narrative review of this unique drug in pain management is presented. Its history is traced from its conception, and its heritage, as a phencyclidine offspring, delineated. The earliest roots of the conceptions concerning the mechanisms of action are sought, and then followed in preclinical as well as clinical research. The major proposed mechanisms in the literature are commented on and evaluated. The growth of the clinical evidence for perioperative pain, acute pain, and chronic pain is followed from early attempts to systematic reviews. Finally, an attempt is made to ...
Source: CNS Neuroscience and Therapeutics - May 23, 2013 Category: Neuroscience Authors: Persson J Tags: CNS Neurosci Ther Source Type: research

Do women and providers value the same features of contraceptive products? Results of a best-worst stated preference experiment.
Conclusion Women and GPs differed in their ranking of contraceptive characteristics. Long duration of use, high efficacy, minimal or no bleeding without pain, were preferred by both. Very undesirable were heavy periods especially with pain, and low efficacy. PMID: 23557397 [PubMed - in process] (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - May 23, 2013 Category: Reproduction Medicine Authors: Weisberg E, Bateson D, Knox S, Haas M, Viney R, Street D, Fiebig D Tags: Eur J Contracept Reprod Health Care Source Type: research

Sickness absence due to musculoskeletal diagnoses and risk of diagnosis-specific disability pension: A nationwide Swedish prospective cohort study
In conclusion, this nationwide cohort study reveals strongly increased risks of all-cause and diagnosis-specific disability pension among those sickness absent due to musculoskeletal diagnoses. (Source: Pain)
Source: Pain - May 23, 2013 Category: Anesthesiology Authors: Catarina Jansson, Kristina Alexanderson Tags: Research papers Source Type: research

The Pain Course: A randomised controlled trial of a clinician-guided Internet-delivered cognitive behaviour therapy program for managing chronic pain and emotional well-being
Summary: Examination of a clinician-guided Internet-delivered cognitive behaviour therapy program for chronic pain found significant improvements in disability, anxiety, depression, and average pain ratings.Abstract: The present study evaluated the efficacy of a clinician-guided Internet-delivered cognitive behaviour therapy (iCBT) program, the Pain Course, to reduce disability, anxiety, and depression associated with chronic pain. Sixty-three adults with chronic pain were randomised to either a Treatment Group or waitlist Control Group. Treatment consisted of 5 iCBT-based lessons, homework tasks, additional resources, wee...
Source: Pain - May 23, 2013 Category: Anesthesiology Authors: Blake F. Dear, Nick Titov, Kathryn Nicholson Perry, Luke Johnston, Bethany M. Wootton, Matthew D. Terides, Ron M. Rapee, Jennifer L. Hudson Tags: Research papers Source Type: research

Disabling musculoskeletal pain in working populations: Is it the job, the person, or the culture?
Summary: Large international variation in the prevalence of disabling forearm and low back pain was only partially explained by established personal and socioeconomic risk factors.Abstract: To compare the prevalence of disabling low back pain (DLBP) and disabling wrist/hand pain (DWHP) among groups of workers carrying out similar physical activities in different cultural environments, and to explore explanations for observed differences, we conducted a cross-sectional survey in 18 countries. Standardised questionnaires were used to ascertain pain that interfered with everyday activities and exposure to possible risk factor...
Source: Pain - May 23, 2013 Category: Anesthesiology Authors: David Coggon, Georgia Ntani, Keith T. Palmer, Vanda E. Felli, Raul Harari, Lope H. Barrero, Sarah A. Felknor, David Gimeno, Anna Cattrell, Consol Serra, Matteo Bonzini, Eleni Solidaki, Eda Merisalu, Rima R. Habib, Farideh Sadeghian, M. Masood Kadir, Sudat Tags: Research papers Source Type: research

Editorial Board
(Source: Pain)
Source: Pain - May 23, 2013 Category: Anesthesiology Source Type: research

Sugar water injections may help ease knee pain
NEW YORK (Reuters Health) - Knee pain appears to decrease up to one year after "prolotherapy," a series of sugar water injections at the site of the pain, according to a new study. (Source: Reuters: Health)
Source: Reuters: Health - May 23, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Visceral Larva Migrans Presenting with Hypereosinophilia.
Abstract Toxocariasis is an infection caused by the ingestion of larvae of the dog Toxocara canis or the cat Toxocara cati. A 2.5 year old boy was admitted to our clinics with fever, abdominal pain and loss of appetite. His medical history included geophagia (pica) and amebiasis infection. On admission, the physical examination revealed hepatomegaly and pallor. There was marked eosinophilia with leukocytosis, anemia, hypergammaglobulinemia and elevated serum Ig E titers. Toxocariasis was confirmed by anti-Toxocara IgG and Western blot. After 7 days of albendazole therapy, leukocytosis persisted and a second course ...
Source: Turkish Society for Parasitology - May 23, 2013 Category: Parasitology Authors: Ecevit C, Bağ O, Vergin C, Oztürk A Tags: Turkiye Parazitol Derg Source Type: research

[Strongyloidosis Caused Loeffler's Syndrome in an Immunosuppressed Patient Who Uses Cronic Steroid].
We report a case of Strongiloides stercoralis infection and Loeffler syndrome that developed in a patient who had systemıc prednisolone. Thepatient in the pulmonary disease department clinic was examined because of right lung upper lobe mass image, and referred to us with complaints of abdominal pain, diarrhea and pruritus. Peripheral smear showed 43% eosinophilia. Parasitological examination of faeces showed larvae of Strongyloides stercoralis. Parasitosis and Loeffler's syndrome was considered in the patient. Thepatient's complaints declined significantly after treatment with albendazole. (Turkiye Parazitol Derg 2013; 3...
Source: Turkish Society for Parasitology - May 23, 2013 Category: Parasitology Authors: Ekmekci OO, Tahmaz M, Altıparmak S, Gülaçtı G, Ergen AK, Kumbasar AB, Sepetcioğlu S, Oner YA Tags: Turkiye Parazitol Derg Source Type: research

[Investigation of cryptosporidiosis by serologic and microscopic method and examination of tap water samples for oocysts].
Conclusion: Cryptosporidiosis was found to be present in 3.4 percent of this group of people, and the distribution of infection among subjects was understood to be not statistically meaningful by gender, age and identification methods (p > 0.05). Finding of oocysts in only one sample out of 30 (3.3%) led to a need for reconsideration of other causal factors in the epidemiology. (Turkiye Parazitol Derg 2013; 37: 9-12). PMID: 23619038 [PubMed - in process] (Source: Turkish Society for Parasitology)
Source: Turkish Society for Parasitology - May 23, 2013 Category: Parasitology Authors: Akdemir C Tags: Turkiye Parazitol Derg Source Type: research

TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate.
Conclusion The results of this work contribute information regarding the antinociceptive properties of CAT on acute pain and show that, at least in part, TRPV1, TRPM8, ASIC, glutamate receptors, PKC and PKA participate in CAT's antinociceptive mechanism. PMID: 23562495 [PubMed - in process] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 23, 2013 Category: Molecular Biology Authors: Rios ER, Rocha NF, Carvalho AM, Vasconcelos LF, Dias ML, de Sousa DP, de Sousa FC, de França Fonteles MM Tags: Chem Biol Interact Source Type: research

Anti-nociceptive effect of IL-12p40 in a rat model of neuropathic pain.
This study investigated pain response following systemic administration of IL-12p70 and IL-12p40 homodimer in chronic neuropathic pain model, induced by chronic constriction injury. The doses tested were IL-12p40 homodimer or IL12p70 at 15, 150 and 1500ng/kg, respectively. Pain was assessed at 1, 4, 7 and 24h after injection, in the form of tactile allodynia and mechanical hyperalgesia. The side effect of sensory motor disability was measured by rotarod performance. By all behavioral measures, IL-12p70 of any dosage, at any time point, had no significant effect on tactile allodynia and mechanical hyperalgesia. A high dose ...
Source: Cytokine - May 23, 2013 Category: Molecular Biology Authors: Chen IF, Khan J, Noma N, Hadlaq E, Teich S, Benoliel R, Eliav E Tags: Cytokine Source Type: research

Evaluation of a non-invasive, inhalational challenge method for rabies vaccine potency assay.
The objective of this study was to evaluate the intranasal route of challenge as a modification to the NIH test to reduce animal pain and suffering until harmonized requirements for in vitro testing of rabies vaccines are developed. Results confirm the intranasal route is an effective route of rabies challenge in mice. However, a valid challenge requires the use of a more concentrated inoculum, in comparison to the intracranial method. PMID: 23557669 [PubMed - in process] (Source: Journal of Virological Methods)
Source: Journal of Virological Methods - May 23, 2013 Category: Virology Authors: Lewis CE, Reising MM, Fry AM, Conrad SK, Siev D, Gatewood DM, Hermann JR Tags: J Virol Methods Source Type: research

Single Inter-space Videoscopic Lobectomy – A Five Year Experience
Introduction: Video Assisted Thoracoscopy (VAT) is a procedure that has been increasing in clinical practice over recent years. Many centres performing ‘videoscopic’ lobectomies still utilise rib retraction and place ports in multiple intercostal spaces. The main impetus for the development of a totally videoscopic (no rib retraction) approach was to reduce the incidence of post-thoracotomy chronic pain attributable to intercostal nerve traction or crush injury at the time of rib retraction . Furthermore, through the utilisation of a single intercostal space, any potential nerve damage is limited to a single intercosta...
Source: Heart, Lung and Circulation - May 23, 2013 Category: Cardiology Authors: Jason A. Varzaly, Craig Jurisevic Tags: Abstracts Source Type: research

Kocuria kristinae endocarditis related to diabetic foot infection.
We report an unusual case of endocarditis occurring in a 74-year-old man with a history of systemic hypertension, diabetes mellitus and minor amputation for left forefoot ulcer. The patient was hospitalized for vacuum-assisted closure therapy to aid in wound healing. After the first treatment session, the patient reported abdominal pain with haematemesis and fever (40 °C). Owing to persistent fever, three blood cultures were performed, all positive for Kocuria kristinae. The identification was based on biochemical tests and automated systems. The speciation of the micro-organism was achieved with MALDI-TOF and then confir...
Source: Journal of Medical Microbiology - May 23, 2013 Category: Microbiology Authors: Citro R, Prota C, Greco L, Mirra M, Masullo A, Silverio A, Bossone E, Piscione F Tags: J Med Microbiol Source Type: research

In Leishmania major-induced inflammation, interleukin-13 reduces hyperalgesia, down-regulates IL-1β and up-regulates IL-6 in an IL-4 independent mechanism.
In this study we correlated the pain thresholds and the levels of IL-1β, IL-6 and IL-4 with the period of IL-13 treatment and beyond it in mice infected with high and low dose of L. major. The results of both models show that IL-1β plays no direct role in provoking the observed hyperalgesia after stopping the treatment with IL-13 which is in contrary to IL-6 which might be a key player after the treatment period. Furthermore we demonstrate that there is no correlation between the levels of IL-4, hyperalgesia, the decreased IL-1β levels and the increased levels of IL-6 in the paws of IL-13 treated and L. major (high and ...
Source: Experimental Parasitology - May 23, 2013 Category: Parasitology Authors: Karam MC, Merckbawi R, El-Kouba JE, Bazzi SI, Bodman-Smith KB Tags: Exp Parasitol Source Type: research

Effects of buprenorphine and meloxicam analgesia on induced cerebral ischemia in C57BL/6 male mice.
Abstract Laboratory mice constitute an extensively used model to study the pathologic and functional outcomes of cerebral ischemic stroke. The middle cerebral artery occlusion (MCAO) model requires surgical intervention, which potentially can result in postsurgical pain and stress. In the present study, we investigated whether buprenorphine and meloxicam, at clinically relevant doses provided pain relief without altering infarct volume in male C57BL/6 mice. Common known side-effects of buprenorphine, including decreased food consumption, were noted after surgery in buprenorphine-treated mice, but these effects were...
Source: Comparative Medicine - May 23, 2013 Category: Zoology Authors: Jacobsen KR, Fauerby N, Raida Z, Kalliokoski O, Hau J, Johansen FF, Abelson KS Tags: Comp Med Source Type: research

Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta.
Abstract Infection with helminth parasites triggers strong and stereotypic immune responses in humans and mice, which can protect against specific experimentally-induced autoimmune diseases. We have shown that infection with the rat tapeworm, Hymenolepis diminuta, confers a protective effect on FCA-induced joint inflammation. Here, we investigated the effect of a prophylactic infection with H. diminuta on the K/BxN-serum model of polyarthritis in BALB/c mice. Mice were infected with 10 cysticercoids of H. diminuta by oral gavage and 8days later arthritis was induced by i.p. injection of K/BxN arthritogenic serum. J...
Source: International Journal for Parasitology - May 23, 2013 Category: Parasitology Authors: Graepel R, Leung G, Wang A, Villemaire M, Jirik FR, Sharkey KA, McDougall JJ, McKay DM Tags: Int J Parasitol Source Type: research

Deal with your chronic pain
Chronic pain conditions now affect more than 116 million Americans, according to the Institute of Medicine, a figure that dwarfs the number of people who suffer from diabetes, coronary heart disease/stroke and cancer combined. (Source: CNN.com - Health)
Source: CNN.com - Health - May 23, 2013 Category: Consumer Health News Source Type: news

Pain, chronic pain, and sickle cell chronic pain.
PMID: 23514387 [PubMed - indexed for MEDLINE] (Source: The American Journal of Bioethics : AJOB)
Source: The American Journal of Bioethics : AJOB - May 23, 2013 Category: Medical Ethics Authors: Amundson R Tags: Am J Bioeth Source Type: research

Shoulder pain and mobility deficits: adhesive capsulitis.
Abstract The Orthopaedic Section of the American Physical Therapy Association (APTA) has an ongoing effort to create evidence-based practice guidelines for orthopaedic physical therapy management of patients with musculoskeletal impairments described in the World Health Organization's International Classification of Functioning, Disability, and Health (ICF). The purpose of these clinical practice guidelines is to describe the peer-reviewed literature and make recommendations related to adhesive capsulitis.J Orthop Sports Phys Ther 2013;43(5):A1-A31. doi:10.2519/jospt.2013.0302. PMID: 23636125 [PubMed - in proce...
Source: Health Physics - May 23, 2013 Category: Physics Authors: Kelley MJ, Shaffer MA, Kuhn JE, Michener LA, Seitz AL, Uhl TL, Godges JJ, McClure PW Tags: J Orthop Sports Phys Ther Source Type: research

A comparison of cyst wall curettage and en bloc excision in the treatment of aneurysmal bone cysts
Conclusions: Curettage is a standard procedure in ABC management. En bloc excision is another option, albeit more technically demanding, that may be considered in recurrent lesions with extensive bone destruction or for cysts in an expendable location. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - May 23, 2013 Category: Cancer & Oncology Authors: Pawel FlontMarta Kolacinska-FlontKryspin Niedzielski Source Type: research

5 ways to handle chronic pain
Chronic pain conditions now affect more than 116 million Americans, according to the Institute of Medicine, a figure that dwarfs the number of people who suffer from diabetes, coronary heart disease/stroke and cancer combined. (Source: WDSU.com - Health)
Source: WDSU.com - Health - May 22, 2013 Category: Consumer Health News Source Type: news

Children With Abdominal Pain Have Poor PrognosisChildren With Abdominal Pain Have Poor Prognosis
Children who present to primary care with abdominal pain have a high risk of developing chronic abdominal pain and long-term functional impairment. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 22, 2013 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Chapter Two Inflammation-Related Disorders in the Tryptophan Catabolite Pathway in Depression and Somatization
Publication date: 2012 Source:Advances in Protein Chemistry and Structural Biology, Volume 88 Author(s): George Anderson , Michael Maes , Michael Berk A recent study—comparing those with depression, somatization, comorbid depression+somatization, and controls—showed specific changes in the tryptophan catabolite (TRYCAT) pathway in somatization, specifically lowered tryptophan and kynurenic acid, and increased kynurenine/kynurenic acid (KY/KA) and kynurenine/tryptophan ratios. These findings suggest that somatization and depression with somatization are characterized by increased activity of indoleamine 2,3-dioxygenas...
Source: Advances in Protein Chemistry and Structural Biology - May 22, 2013 Category: Biochemistry Source Type: research

Memory decay and susceptibility to amnesia dissociate punishment- from relief-learning.
Abstract Painful events shape future behaviour in two ways: stimuli associated with pain onset subsequently support learned avoidance (i.e. punishment-learning) because they signal future, upcoming pain. Stimuli associated with pain offset in turn signal relief and later on support learned approach (i.e. relief-learning). The relative strengths of such punishment- and relief-learning can be crucial for the adaptive organization of behaviour in the aftermath of painful events. Using Drosophila, we compare punishment- and relief-memories in terms of their temporal decay and sensitivity to retrograde amnesia. During t...
Source: Biology Letters - May 22, 2013 Category: Biology Authors: Diegelmann S, Preuschoff S, Appel M, Niewalda T, Gerber B, Yarali A Tags: Biol Lett Source Type: research

Migraine, Chronic Back Pain Tied to Higher Suicide Risk
Hopelessness, disability may play a role in feelings of despair, study finds (Source: WebMD Health)
Source: WebMD Health - May 22, 2013 Category: Consumer Health News Source Type: news

As Brain Goes, So Goes the Heart (CME/CE)
(MedPage Today) -- Six weeks of treatment with the antidepressant escitalopram (Lexapro) resulted in a lower rate of mental stress-induced chest pain in patients with stable coronary heart disease, a small randomized study found. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - May 22, 2013 Category: Consumer Health News Source Type: news

Invertebrate welfare: an overlooked issue.
Abstract While invertebrates make up the majority of animal species, their welfare is overlooked compared to the concern shown to vertebrates. This fact is highlighted by the near absence of regulations in animal research, with the exception of cephalopods in the European Union. This is often justified by assumptions that invertebrates do not experience pain and stress while lacking the capacity for higher order cognitive functions. Recent research suggests that invertebrates may be just as capable as vertebrates in experiencing pain and stress, and some species display comparable cognitive capacities. Another obst...
Source: Ann Ist Super Sanita - May 22, 2013 Category: Biomedical Science Authors: Horvath K, Angeletti D, Nascetti G, Carere C Tags: Ann Ist Super Sanita Source Type: research

An Increase in Synaptic NMDA Receptors in the Insular Cortex Contributes to Neuropathic Pain.
Abstract Neurons in the insular cortex are activated by acute and chronic pain, and inhibition of neuronal activity in the insular cortex has analgesic effects. We found that in a mouse model in which peripheral nerve injury leads to the development of neuropathic pain, the insular cortex showed changes in synaptic plasticity, which were associated with a long-term increase in the amount of synaptic N-methyl-d-aspartate receptors (NMDARs), but not that of extrasynaptic NMDARs. Activation of cyclic adenosine monophosphate (cAMP)-dependent signaling enhanced the amount of synaptic NMDARs in acutely isolated insular c...
Source: Science Signaling - May 22, 2013 Category: Biomedical Science Authors: Qiu S, Chen T, Koga K, Guo YY, Xu H, Song Q, Wang JJ, Descalzi G, Kaang BK, Luo JH, Zhuo M, Zhao MG Tags: Sci Signal Source Type: research

Migraine, Chronic Back Pain Tied to Higher Suicide Risk
Hopelessness, disability may play a role in feelings of despair, study finds Source: HealthDay Related MedlinePlus Pages: Back Pain, Migraine, Suicide (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - May 22, 2013 Category: Consumer Health News Source Type: news

Chronic pain? 5 tips
Chronic pain conditions now affect more than 116 million Americans, according to the Institute of Medicine, a figure that dwarfs the number of people who suffer from diabetes, coronary heart disease/stroke and cancer combined. (Source: CNN.com - Health)
Source: CNN.com - Health - May 22, 2013 Category: Consumer Health News Source Type: news

Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils.
Abstract Acetaminophen is a frequently prescribed over-the-counter drug to reduce fever and pain in the event of inflammatory process. As neutrophils are relevant cells in inflammatory processes, the putative interaction of acetaminophen with these cells, if present, would be of paramount importance. The present study was undertaken to evaluate the effect of acetaminophen in human neutrophils' oxidative burst and lifespan in vitro. The obtained results demonstrate that acetaminophen efficiently modulates neutrophils' oxidative burst in phorbol myristate acetate-activated neutrophils, in a concentration-dependent ma...
Source: Toxicology Letters - May 22, 2013 Category: Toxicology Authors: Freitas M, Costa VM, Ribeiro D, Couto D, Porto G, Carvalho F, Fernandes E Tags: Toxicol Lett Source Type: research

Incidence of abnormalities in temporomandibular joints in a population of 1,100 urban and rural patients lacking teeth and other parafunctions in 2003-2008. An international problem.
CONCLUSIONS: It is extremely important (as it is international problem) to introduce prophylactic care to prevent the occurrence of parafunctional activity in patients from the rural environment. Parafunctions, therefore, should be taken into account in the diagnosing procedure of such disorders and pathological symptoms as pathological tooth wear, sleep disorders, cervicalgia, neck myalgia, shoulder girdle myalgia, and dorsalgia. PMID: 23540218 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - May 22, 2013 Category: Environmental Health Authors: Michalak M, Paulo M, Bożyk A, Zadrożny Ł, Wysokińska-Miszczuk J, Michalak I, Borowicz J Tags: Ann Agric Environ Med Source Type: research

The application of a classification-tree model for predicting low back pain prevalence among hospital staff.
This study proposes a classification-tree model to predict LBP risk levels in Sacré-Cœur Hospital, Lebanon (as a case study-236 chosen staffs) using various predictor individual and occupational factors. The developed tree model explained 80% of variance in LBP risk levels using standing hours/day (90% in relative importance), job status/sitting hours per day (80% each), body mass index (71%), working days/week (63%), domestic activity hours/week (36%), weight (35%), job dissatisfaction/sitting on ergonomic chairs (30% each), height (28%), gender (27%), sufficient break time (26%), using handling techniques/age (25% each...
Source: Archives of Environmental and Occupational Health - May 22, 2013 Category: Environmental Health Authors: Mendelek F, Caby I, Pelayo P, Kheir RB Tags: Arch Environ Occup Health Source Type: research

EndometriosisEndometriosis
This review focuses on the management of pain and infertility in women with endometriosis. Women's Health (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 22, 2013 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news

How to handle chronic pain
Chronic pain conditions now affect more than 116 million Americans, according to the Institute of Medicine, a figure that dwarfs the number of people who suffer from diabetes, coronary heart disease/stroke and cancer combined. (Source: CNN.com - Health)
Source: CNN.com - Health - May 22, 2013 Category: Consumer Health News Source Type: news

5 ways to handle chronic pain
Chronic pain conditions now affect more than 116 million Americans, according to the Institute of Medicine, a figure that dwarfs the number of people who suffer from diabetes, coronary heart disease/stroke and cancer combined. (Source: CNN.com - Health)
Source: CNN.com - Health - May 22, 2013 Category: Consumer Health News Source Type: news

Patients With Low Back Pain Can Be Accurately Assessed Via Telerehabilitation
A new "telerehabilitation" approach lets physical therapists assess patients with low back pain (LBP) over the Internet, with good accuracy compared with face-to-face examinations, reports a study in the journal Spine. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. Taking advantage of Skype and other widely-used services may make telerehabilitation a more feasible alternative to in-person clinic visits, according to the new research by Prof. Manuel Arroyo-Morales and colleagues of University of Granada, Spain... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 22, 2013 Category: Consumer Health News Tags: Back Pain Source Type: news

Cognitive Function in Older Patients with Postherpetic Neuralgia
ConclusionThis study shows the deleterious effect of systemic PHN treatment on several domains of cognition. Cognitive impairment associated with pain and antidepressants may be reversed by topical pain management. Topical treatment with 5% lidocaine medicated plaster is a valuable alternative for pain alleviation and maintains cognitive integrity in this vulnerable population. (Source: Pain Practice)
Source: Pain Practice - May 22, 2013 Category: Anesthesiology Authors: Gisèle Pickering, Bruno Pereira, Florentin Clère, Marc Sorel, Geraldine Montgazon, Malou Navez, Pascale Picard, Delphine Roux, Véronique Morel, Rachida Salimani, Mireille Adda, Valérie Legout, Claude Dubray Tags: Original Article Source Type: research

Report of a Preliminary Discontinued Double‐Blind, Randomized, Placebo‐Controlled Trial of the Anti‐TNF‐α Chimeric Monoclonal Antibody Infliximab in Complex Regional Pain Syndrome
ConclusionsThis study was terminated before the required number of participants had been reached for sufficient statistical power. Nevertheless, a trend was found toward an effect of infliximab on the initially high TNF‐α concentration. (Source: Pain Practice)
Source: Pain Practice - May 22, 2013 Category: Anesthesiology Authors: Maaike Dirckx, George Groeneweg, Feikje Wesseldijk, Dirk L. Stronks, Frank J.P.M. Huygen Tags: Original Article Source Type: research