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Health news: Pomegranates can speed up labour, new psoriasis drug offers greater relief and a dose of herbs could banish fluEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pomegranates could help speed up childbirth - and may reduce the number of emergency Caesarean sections performed as a result of long labour. (Source: the Mail online | Health)
Source: the Mail online | Health - February 9, 2010 Category: Consumer Health News Source Type: news

SMC accepts restricted use of ustekinumab (Stelara®) for psoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Scottish Medicines Consortium (SMC) Area: Evidence > Drug Specific Reviews Following a full submission, the Scottish Medicines Consortium (SMC) has accepted ustekinumab (Stelara®) for restricted use within NHS Scotland for the treatment of moderate to severe plaque psoriasis in adults who failed to respond to, or who have a contraindication to, or are intolerant to other systemic therapies including ciclosporin, methotrexate and psoralen and UVA treatment (PUVA).  Continued treatment should be restricted to patients who achieve a PASI 75 response within 16 weeks.   This advice takes account of a Pat...
Source: NeLM - Drug Specific Reviews - February 8, 2010 Category: Drugs & Pharmacology Source Type: organizations

Methotrexate enhances NBUVB treatment of psoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The combination of methotrexate and narrowband ultraviolet B phototherapy may offer psoriasis patients more rapid clinical improvement of their symptoms than narrowband ultraviolet B phototherapy alone, research suggests. (Source: MedWire News - Psoriasis)
Source: MedWire News - Psoriasis - February 6, 2010 Category: Dermatology Source Type: news

Tailor Etanercept to Symptoms in Psoriasis and Psoriatic Arthritis (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The decision to use once-weekly or twice-weekly etanercept in patients with both psoriasis and psoriatic arthritis should be determined by the cutaneous and joint symptoms of the patient, researchers said. (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - February 5, 2010 Category: Dermatology Source Type: news

Methotrexate enhances NBUVB treatment of psoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The combination of methotrexate and narrowband ultraviolet B phototherapy may offer psoriasis patients more rapid clinical improvement of their symptoms than narrowband ultraviolet B phototherapy alone, research suggests. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - February 5, 2010 Category: Dermatology Source Type: news

Comparison of two etanercept regimens for treatment of psoriasis and psoriatic arthritis: PRESTA randomised double blind multicentre trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives To compare the efficacy over 12 weeks of two different etanercept regimens in treating the skin manifestations of psoriasis in patients who also have psoriatic arthritis and to evaluate... (Source: BMJ Online First)
Source: BMJ Online First - February 3, 2010 Category: Journals (General) Authors: Sterry, W., Ortonne, J.-P., Kirkham, B., Brocq, O., Robertson, D., Pedersen, R. D, Estojak, J., Molta, C. T, Freundlich, B. Tags: Degenerative joint disease, Musculoskeletal syndromes, Dermatology RESEARCH Source Type: journals

Efficacy of a far erythemogenic dose of narrow-band ultraviolet B phototherapy in chronic plaque-type psoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the present study was to examine the effect of far erythemogenic dose of narrow-band ultraviolet B (NB-UVB; starting dose at 35% minimal erythematous dose [MED]) on clinical response by measuring the severity, extent of disease and the changes in quality of life. Fifty patients with chronic plaque-type psoriasis were enrolled. Therapy was held for 3 days a week. The severity of the disease was assessed based on the Psoriasis Area and Severity Index (PASI) score and Dermatology Life Quality Index (DLQI) scores. The percentage improvement of PASI at 30 sessions was 68.99%. The improvement in DLQI scores at 30 sess...
Source: The Journal of Dermatology - February 3, 2010 Category: Dermatology Authors: Rutsanee AKARAPHANTH, Yotsinee KITTIPAVARA, Nataya VORAVUTINON, Usa WACHIRATARAPADORN, Pimonpun GRITIYARANGSAN Tags: Original Articles Source Type: journals

Comorbidities associated with psoriasis: An experience from the Middle EastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies suggest that psoriasis patients have higher rates of comorbidities. We sought to determine the prevalence of comorbidities and co-medications in our psoriasis patients. We conducted case-control study in 1835 patients with psoriasis vulgaris and age- and gender-matched cohort without psoriasis. Patients were examined for clinical characteristics of psoriasis, PASI scores, and data of age, sex, body mass index (BMI), smoking status, comorbidities, and co-medications were analysed for both patients and controls. We identified 1661 (92.8%) patients with mild to moderate psoriasis (PASI < 10) and 129 patient's (...
Source: The Journal of Dermatology - February 3, 2010 Category: Dermatology Authors: Nawaf AL-MUTAIRI, Shahat AL-FARAG, Ahmed AL-MUTAIRI, Mazen AL-SHILTAWY Tags: Original Articles Source Type: journals

Etanercept in psoriasis: initial twice weekly treatment brings faster improvement to skin but not jointsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to determine whether either regimen was superior in patients with both skin and joint symptoms. Participants were adults with active but stable moderate to severe psoriasis and active psoriatic arthropathy. They were randomised to etanercept 50mg once or twice weekly for 12 weeks, with matching placebo in the once weekly group to maintain blinding. After the 12 week study period, all received open-label once weekly etanercept for a further 12 weeks. Primary outcome was the proportion of participants who achieved "clear" or ... (Source: NeLM - News)
Source: NeLM - News - February 3, 2010 Category: Drugs & Pharmacology Source Type: organizations

High Prevalence of Potential Drug-Drug Interactions for Psoriasis Patients Prescribed Methotrexate or Cyclosporine for Psoriasis: Associated Clinical and Economic Outcomes in Real-World PracticeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dermatology (DOI:10.1159/000275198) (Source: Dermatology)
Source: Dermatology - February 2, 2010 Category: Dermatology Source Type: journals

Psoriasis treatment: Can fish oil supplements reduce symptoms?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Psoriasis treatment — Fish oil supplements may be helpful, but use caution. (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - February 2, 2010 Category: Consumer Health News Source Type: news

Psoriasis treatment: Can fish oil supplements reduce symptoms?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Psoriasis treatment — Fish oil supplements may be helpful, but use caution. (Source: MayoClinic.com - Ask a Specialist)
Source: MayoClinic.com - Ask a Specialist - February 2, 2010 Category: Consumer Health News Source Type: news

Relationships between obesity and the clinical severity of psoriasis in TaiwanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In psoriasis patients, obesity is associated with a more severe disease, especially in men. Bodyweight control may be important for the management of psoriasis. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - February 2, 2010 Category: Dermatology Authors: Y-H Huang, L-C Yang, RC-Y Hui, Y-C Chang, Y-W Yang, C-H Yang, Y-H Chen, W-H Chung, Y-Z Kuan, C-S Chiu Source Type: journals

Effect of cyclosporine on blood pressureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Cochrane Library Area: Evidence > Medication Safety Abstract   Background Cyclosporine is an immunosuppressive agent used for different autoimmune diseases. The official Canadian indications for cyclosporine are solid organ transplantation, bone marrow transplantation, psoriasis, rheumatoid arthritis and nephritic syndrome (e-CPS 2008). The expanding range of indications for cyclosporine therapy will lead to more patients receiving chronic therapy with possible side effects, hypertension being one of the most common. Therefore it is essential to know the magnitude of increase of blood pressure (BP) associ...
Source: NeLM - Patient Safety - February 2, 2010 Category: Drugs & Pharmacology Source Type: organizations

The uses and properties of almond oil.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Almond oil [Oleum amygdalae] has long been used in complementary medicine circles for its numerous health benefits. Although no conclusive scientific data exists currently, almonds and almond oil have many properties including anti-inflammatory, immunity-boosting and anti-hepatotoxicity effects. Further, associations between almond oil and improved bowel transit have been made, which consequently reduces irritable bowel syndrome symptoms. Further, some studies show a reduced incidence of colonic cancer. Moreover, cardiovascular benefits have also been identified with almond oil elevating the levels of so-called 'good c...
Source: Complementary Therapies in Clinical Practice - February 1, 2010 Category: Complementary Medicine Authors: Ahmad Z Tags: Complement Ther Clin Pract Source Type: journals

IL-1 from epithelial cells fosters T-cell dependent skin inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion IL-1 secretion and the physical contact between keratinocytes and activated, infiltrating T-cells may be central for the development of chronic inflammatory skin conditions. PMID: 20128791 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 1, 2010 Category: Dermatology Authors: Renne J, Schäfer V, Werfel T, Wittmann M Tags: Br J Dermatol Source Type: journals

Phosphodiesterase 7A inhibitor ASB16165 impairs proliferation of keratinocytes in vitro and in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Excessive proliferation of epidermal keratinocytes is a typical aspect of chronic skin diseases such as psoriasis. In the present study, effect of phosphodiesterase 7A (PDE7A) inhibitor ASB16165 on proliferation of keratinocytes was investigated to examine the role of PDE7A in keratinocyte proliferation and the possible therapeutic relevance of PDE7A inhibition in psoriasis. Topical application of ASB16165 inhibited the increase of thickness of skin as well as epidermis in a skin inflammation model induced by repeated painting of 12-O-tetradecanoylphorbol-13-acetate (TPA) in a concentration-dependent manner. The ASB161...
Source: European Journal of Pharmacology - February 1, 2010 Category: Drugs & Pharmacology Authors: Goto M, Kadoshima-Yamaoka K, Murakawa M, Yoshioka R, Tanaka Y, Inoue H, Murafuji H, Kanki S, Hayashi Y, Nagahira K, Ogata A, Nakatsuka T, Fukuda Y Tags: Eur J Pharmacol Source Type: journals

The patient's journey: living with psoriasis - the doctors' perspective.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 20132723 [PubMed - in process] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - February 1, 2010 Category: Primary Care Authors: Alexandroff AB, Johnston GA Tags: Br J Gen Pract Source Type: journals

The patient's journey: living with psoriasis - the patient's perspective.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 20132722 [PubMed - in process] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - February 1, 2010 Category: Primary Care Authors: Pickering H Tags: Br J Gen Pract Source Type: journals

No increased cancer risk with coal tar treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers say that coal tar for the treatment of psoriasis and eczema should not be abandoned, after finding concerns of an associated increased risk for cancer are unfounded. (Source: MedWire News - Psoriasis)
Source: MedWire News - Psoriasis - January 30, 2010 Category: Dermatology Source Type: news

Photoleukomelanoderma possibly caused by etretinate in a patient with psoriasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 20107735 [PubMed - in process] (Source: Acta Derm Venereol A...)
Source: Acta Derm Venereol A... - January 30, 2010 Category: Dermatology Authors: Seishima M, Shibuya Y, Kato G, Watanabe K Tags: Acta Derm Venereol Source Type: journals

Skin pain and discomfort in psoriasis: an exploratory study of symptom prevalence and characteristics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, pain and discomfort are more common and more severe in patients with psoriasis than previously estimated. PMID: 20107724 [PubMed - in process] (Source: Acta Derm Venereol A...)
Source: Acta Derm Venereol A... - January 30, 2010 Category: Dermatology Authors: Ljosaa TM, Rustoen T, Mörk C, Stubhaug A, Miaskowski C, Paul SM, Wahl AK Tags: Acta Derm Venereol Source Type: journals

Psoriasis and hypertension: a case-control study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In recent years, numerous reports have demonstrated an association between psoriasis and metabolic syndrome. However, some studies failed to demonstrate an association between psoriasis and hypertension. The aim of the present study was to examine the association between psoriasis and hypertension. Psoriasis patients of a health-maintenance organization were compared with enrollees without psoriasis regarding the prevalence of hypertension in a case-control study. The study included 12,502 psoriasis patients over the age of 20 years and 24,285 age- and sex-frequency-matched controls. The prevalence of hypertension was ...
Source: Acta Derm Venereol A... - January 30, 2010 Category: Dermatology Authors: Cohen AD, Weitzman D, Dreiher J Tags: Acta Derm Venereol Source Type: journals

No increased cancer risk with coal tar treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers say that coal tar for the treatment of psoriasis and eczema should not be abandoned, after finding concerns of an associated increased risk for cancer are unfounded. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - January 29, 2010 Category: Dermatology Source Type: news

Clinical Picture of the Week: Severe psoriasis during pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This woman developed severe psoriasis during pregancy. (Source: Pulse Today Clinical Updates)
Source: Pulse Today Clinical Updates - January 28, 2010 Category: Primary Care Tags: Article Source Type: info

Clinical Picture of the Week: Pustular psoriasis during pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This woman developed severe psoriasis during pregancy. (Source: Pulse Today Clinical Updates)
Source: Pulse Today Clinical Updates - January 28, 2010 Category: Primary Care Tags: Article Source Type: info

Prevalence of metabolic syndrome in Japanese psoriasis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metabolic syndrome is a constellation of multiple risk factors including central obesity, dyslipidemia, glucose intolerance, and elevated blood pressure. The syndrome is associated with cardiovascular disease and type 2 DM , and non-alcoholic steatohepatitis (NASH) . Several reports indicate the association between psoriasis and DM, hypertension, obesity, and metabolic syndrome in Caucasian and Chinese psoriasis . Although we have shown the increased prevalence of obesity and adiposity in Japanese psoriasis , the incidence of DM, hypertension, cardiovascular disease, and the metabolic syndrome remains to be determined. (So...
Source: Journal of Dermatological Science - January 28, 2010 Category: Dermatology Authors: Hidetoshi Takahashi, Ichiro Takahashi, Masaru Honma, Akemi Ishida-Yamamoto, Hajime Iizuka Tags: Letters to the Editor Source Type: journals

Up-regulation of serpin SCCA1 is associated with epidermal barrier disruptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All of our findings indicate that SCCA1 plays an important role in the induction of epidermal barrier disruption. SCCA1 may be a critical determinant of barrier function in the epidermis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 28, 2010 Category: Dermatology Authors: Chika Katagiri, Toshii Iida, Jotaro Nakanishi, Maki Ozawa, Setsuya Aiba, Toshihiko Hibino Tags: Regular articles Source Type: journals

Tumor necrosis factor [alpha] blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was undertaken to explore the mechanisms underlying TNF[alpha] blockade-induced exacerbation of skin inflammation in murine psoriasis-like skin disease.Skin inflammation was induced in BALB/c scid/scid mice after they received CD4+CD45RBhighCD25- (naive CD4) T cells from donor mice. These mice were treated with either anti-interleukin-12 (anti-IL-12)/23p40 antibody or murine TNFRII-Fc fusion protein and were examined for signs of disease, including histologic features, various cytokine levels in the serum, and cytokine or FoxP3 transcripts in the affected skin and draining lymph node (LN) cells. In a separate st...
Source: Arthritis and Rheumatism - January 28, 2010 Category: Rheumatology Authors: Hak-Ling Ma, Lee Napierata, Nancy Stedman, Stephen Benoit, Mary Collins, Cheryl Nickerson-Nutter, Deborah A. Young Tags: psoriasis Source Type: journals

Infliximab: Psoriasis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - January 27, 2010 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Slide show: Types of psoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Psoriasis pictures — See pictures of types of psoriasis, including guttate psoriasis and scalp psoriasis. (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - January 27, 2010 Category: Consumer Health News Source Type: news

Effectiveness of adalimumab in treating patients with active psoriatic arthritis and predictors of good clinical responses for arthritis, skin and nail lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Adalimumab was effective in patients with PsA. Lower impairment of physical function, greater pain, male sex and no systemic treatment with glucocorticoids were factors that increased the chance of achieving a good clinical response. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - January 26, 2010 Category: Rheumatology Authors: Van den Bosch, F, Manger, B, Goupille, P, McHugh, N, Rodevand, E, Holck, P, van Vollenhoven, R F, Leirisalo-Repo, M, FitzGerald, O, Kron, M, Frank, M, Kary, S, Kupper, H Tags: Unlocked, Pain (neurology), Degenerative joint disease, Musculoskeletal syndromes Clinical and epidemiological research Source Type: journals

CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The frequency of circulating CD14+CD16+ cells was increased in PsA compared to controls. OCP might undergo a transitional state with an intermediate expression of CD16 during osteoclastogenesis. TNFalpha blocks CD16 expression on a subset of CD14+ monocytes. CD16 has the potential to serve as an OCP marker in inflammatory arthritis. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 26, 2010 Category: Rheumatology Authors: Yahui Grace ChiuTianmeng ShaoChangyong FengKofi MensahMichael ThullenEdward SchwarzChristopher Ritchlin Source Type: journals

Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Please cite this paper as: Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice. Experimental Dermatology 2010.Abstract: Topical corticosteroids such as hydrocortisone-17-butyrate (HCB) and clobetasol-17-propionate (CP) and vitamin D3 derivatives such as calcipotriol (CAL) are widely used to treat psoriasis. The immunosuppressive effects of corticosteroids make their topical use a concern for skin carcinogenicity. Few studies have assessed the effect of topical corticosteroids and topical vitamin D3 derivatives on photoca...
Source: Experimental Dermatology - January 25, 2010 Category: Dermatology Authors: Catharina M. Lerche, Peter A. Philipsen, Thomas Poulsen, Hans Christian Wulf Source Type: journals

Sue Visit 1 - A 34-year-old woman with longstanding psoriasis and onset of stiffness and foot pain (CME)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Upon completion of the activity, participants should be able to outline the cutaneous and musculoskeletal features of psoriatic arthritis; discuss the impact of psoriatic arthritis on quality of life and morbidity; identify and manage comorbidities in patients with psoriatic arthritis. (Source: Modern Medicine)
Source: Modern Medicine - January 25, 2010 Category: Journals (General) Source Type: info

Rising psoriasis treatment costs outstrip inflationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cost of systemic therapies for psoriasis in the USA appears to be increasing at a faster rate than inflation, cost model findings suggest. (Source: MedWire News - Psoriasis)
Source: MedWire News - Psoriasis - January 23, 2010 Category: Dermatology Source Type: news

Sue Visit 2 - A 34-year-old woman with longstanding psoriasis and onset of stiffness and foot pain (CME)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Upon completion of the activity, participants should be able to outline the cutaneous and musculoskeletal features of psoriatic arthritis; discuss the impact of psoriatic arthritis on quality of life and morbidity; identify and manage comorbidities in patients with psoriatic arthritis. (Source: Modern Medicine)
Source: Modern Medicine - January 23, 2010 Category: Journals (General) Source Type: info

Rising psoriasis treatment costs outstrip inflationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cost of systemic therapies for psoriasis in the USA appears to be increasing at a faster rate than inflation, cost model findings suggest. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - January 22, 2010 Category: Dermatology Source Type: news

Purification of Antimicrobial Peptides from Human SkinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human skin is a rich source of human antimicrobial peptides. Its cellular source is the keratinocyte, which terminally differentiates in the uppermost parts of the skin, eventually forming the stratum corneum, the horny layer. The easy availability of human stratum corneum makes it possible to identify and characterize human antimicrobial peptides with a biochemical approach. Moreover, the availability of lesional scales of patients with psoriasis, an inflammatory skin disease, allows the identification of human-inducible peptide antibiotics, which are absent in healthy skin. With this strategy, the beta-defensins hBD-2 an...
Source: Springer protocols feed by Immunology - January 22, 2010 Category: Allergy & Immunology Source Type: info

Rising Costs -- the Real Heartbreak of Psoriasis (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Treatment costs for psoriasis have outpaced inflation, researchers said. (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - January 20, 2010 Category: Dermatology Source Type: news

Modulating T cell functions does not alleviate chronic inflammatory skin lesions in K5.TGFβ1 transgenic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Please cite this paper as: Modulating T cell functions does not alleviate chronic inflammatory skin lesions in K5.TGF[beta]1 transgenic mice. Experimental Dermatology 2009.Abstract: To use mice with chronic hyperproliferative skin inflammation as psoriasis models, their thorough phenotypic and functional characterization is indispensable. Mice with keratin 5 promoter-controlled overexpression of latent human Transforming Growth Factor (TGF)[beta]1 within the basal epidermis (K5.TGF[beta]1 mice) show a psoriasiform phenotype, but the underlying pathogenic mechanisms are not entirely clear. To elucidate the contribution of T...
Source: Experimental Dermatology - January 20, 2010 Category: Dermatology Authors: Kai Michaelis, Katrin Wallbrecht, Andreas Kerstan, Niklas Beyersdorf, Cortny Williams, Thomas Kerkau, Xiao-Jing Wang, Thomas Hünig, Michael P. Schön Source Type: journals

Costs of psoriasis treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Findings from a cost model suggest that expenses for systemic psoriasis treatment appear to be increasing at a faster rate than inflation, and newer biologically derived therapys are more expensive than traditional systemic therapies, as per a report in the recent issue of Archives of Dermatology, one of the JAMA/Archives journals........ (Source: Medicineworld.org: New Article Alert)
Source: Medicineworld.org: New Article Alert - January 19, 2010 Category: Consumer Health News Source Type: info

Cost of Psoriasis Drugs Rising Faster Than OthersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Cost of Psoriasis Drugs Rising Faster Than OthersCategory: Health NewsCreated: 1/18/2010 4:10:00 PMLast Editorial Review: 1/19/2010 (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - January 19, 2010 Category: Dermatology Source Type: consumer

Consensus Guidelines for Psoriasis-Related DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
These recommendations will help clinicians quickly review the available data to select the best therapies. Medscape Rheumatology (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - January 19, 2010 Category: Dermatology Tags: Rheumatology Source Type: info

Two psoriasis drugs reduce symptomsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MANCHESTER, England, Jan. 18 (UPI) -- Clinical trials of two prescription drugs for psoriasis were effective in reducing symptoms of psoriasis, British researchers said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - January 19, 2010 Category: Consumer Health News Source Type: news

Pulsed Dye Laser in the Treatment of Nail PsoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The treatment options for nail psoriasis have been limited, and the management of nail psoriasis has been challenging for physicians. To evaluate the effect of pulsed dye laser (PDL) in the treatment of nail psoriasis. Psoriatic nails of five patients were treated using PDL (595 nm) once monthly for 3 months. The pulse duration was 1.5 ms, the beam diameter was 7 mm, and the laser energy was 8.0 to 10.0 J/cm2. Clinical efficacy was statistically evaluated according to Nail Psoriasis Severity Index (NAPSI) score differences before and after the treatment. Statistical analysis of NAPSI scores before and after treatment showe...
Source: Dermatologic Surgery - January 19, 2010 Category: Dermatology Authors: YASEMIN ORAM, YELDA KARINCAOĞLU, ERKAN KOYUNCU, FERAYI KAHARAMAN Source Type: journals

Cost-effectiveness analysis of TNF-α blockers for the treatment of chronic plaque psoriasis in the perspective of the Italian health-care systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study was to perform a cost-effectiveness analysis of infliximab compared with other anti-tumor necrosis factor-[alpha] agents for the treatment of psoriasis in Italy. The incremental cost-effectiveness ratio per patients achieving at least 75% improvement in the psoriasis area and severity index assessed over 24- and 48[ndash]50-week periods was calculated. Efficacy data were drawn from randomized controlled trials when available or from open label studies. Considering patients achieving psoriasis area and severity index at week 24 and 48[ndash]50, infliximab was dominant (more effective and less co...
Source: Dermatologic Therapy - January 19, 2010 Category: Dermatology Authors: Simona de Portu, Micol Del Giglio, Gianfranco Altomare, Fabio Arcangeli, Enzo Berardesca, Piergiacomo Calzavara Pinton, Torello Lotti, Patrizia Martini, Andrea Peserico, Marco Simonacci, Gino A. Vena, Giampiero Girolomoni Tags: SIDeMaST Source Type: journals

Correlation between BMI and PASI in patients affected by moderate to severe psoriasis undergoing biological therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity is common in psoriatic patients, and it has been shown to be important for many aspects of the condition. In particular, low-calorie diets can improve the symptoms and response to treatment in pustular psoriasis. The present study investigates the influence of body-weight alteration on the disease's clinical manifestations in moderate to severe psoriasis patients treated with biological drugs. Finally, the influence of a caloric restriction was assessed. This observational transversal study enrolled 33 patients attending our Severe Psoriasis Outpatient Clinic, who were treated with biological drugs. Body Mass Index...
Source: Dermatologic Therapy - January 19, 2010 Category: Dermatology Authors: F. Bardazzi, R. Balestri, E. Baldi, A. Antonucci, S. De Tommaso, A. Patrizi Tags: SIDeMaST Source Type: journals

Prevalence of autoantibodies in patients of psoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study concludes that the autoantibodies are found to be present in psoriasis patients or latent autoimmune diseases develop in psoriasis patients without any clinical symptoms. J. Clin. Lab. Anal. 24:44-48, 2010. © 2010 Wiley-Liss, Inc. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 19, 2010 Category: Laboratory Medicine Authors: Sangeeta Singh, Usha Singh, Sanjay Singh Tags: Original Articles Source Type: journals

Rising Psoriasis Therapy Costs Far Outstrip InflationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The price of brand-name drugs, and thus the overall cost of treating systemic psoriasis, rose steeply from 2000 to 2008, with the average 66 percent price hike far outstripping the rate of inflation over the same period, according to a study in the January issue of the Archives of Dermatology. (Source: Modern Medicine)
Source: Modern Medicine - January 19, 2010 Category: Journals (General) Source Type: info