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Psoriasis treatment guidelines proposed for patients with concomitant HCVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Pediatrics)
Source: MedWire News - Pediatrics - November 21, 2009 Category: Pediatrics Source Type: news

Psoriasis treatment guidelines proposed for patients with concomitant HCVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - November 21, 2009 Category: Dermatology Source Type: news

An epidemiological survey of low back pain and axial spondyloarthritis in a Chinese Han population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The survey questionnaire for SpA in this study is useful for axial SpA screening in China. In southern China, the prevalence of LBP is 7.21%. The prevalence of axial SpA is 0.782%. USpA is the most common subtype of SpA, followed by AS. PMID: 19922021 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - November 21, 2009 Category: Rheumatology Authors: Liao Z, Pan Y, Huang J, Huang F, Chi W, Zhang K, Lin Z, Wu Y, He W, Wu J, Xie X, Huang J, Wei Q, Li T, Wu Z, Yu B, Gu J Tags: Scand J Rheumatol Source Type: journals

Assessing the Impact of Efalizumab on Nail, Scalp and Palmoplantar Psoriasis and on Quality of Life: Results from a Multicentre, Open-label, Phase IIIb/IV TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This post-approval, open-label trial (n = 1266) assessed the efficacy of efalizumab, administered in accordance with the European label at that time, in patients with concomitant nail, scalp or palmoplantar psoriasis. Patients received subcutaneous efalizumab 1.0 mg/kg weekly for up to 20 weeks. By Week 12, an improvement from baseline of 50% or more was observed in 21.4% (181/844) of patients with nail psoriasis, 62.4% (718/1150) of patients with scalp psoriasis, and 51.4% (127/247) of patients with palmoplantar psoriasis. Quality of life improved throughout the trial, with a 50% median improvement in DLQI score after 12 ...
Source: Archives of Drug Information - November 21, 2009 Category: Drugs & Pharmacology Authors: Andreas Katsambas, Ketty Peris, Gino Vena, Peter Freidmann, Gottfried Wozel, Esteban Daudén, Daiana Licu, Mauro Placchi, Michel De La Brassinne Source Type: journals

Videodermatoscopy enhances diagnostic capability in psoriatic balanitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Balanitis is an inflammatory condition of the glans penis that may be caused by a wide range of dermatologic conditions, including psoriasis. Psoriatic balanitis is clinically characterized by erythematous, nonscaling plaques most commonly located proximally on the glans and under the prepuce. Most often, genital psoriasis is part of a more generalized disease process, but in the case of exclusively penile involvement, the correct diagnosis may be difficult to make, and several investigations, including a skin biopsy, are often necessary. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 19, 2009 Category: Dermatology Authors: Francesco Lacarrubba, Maria Rita Nasca, Giuseppe Micali Tags: Research Letters Source Type: journals

Pain associated with aminolevulinic acid-photodynamic therapy of skin diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Gamma-aminobutyric acid receptors, cold/menthol receptors (transient receptor potential cation channel, subfamily M, member 8), and vanilloid/capsaicin receptors (transient receptor potential cation channel, subfamily V, member 1) may be involved in pain perception during ALA-PDT and are therefore worthy of further investigation. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 19, 2009 Category: Dermatology Authors: Christine B. Warren, Laszlo J. Karai, Allison Vidimos, Edward V. Maytin Tags: Reviews Source Type: journals

CorrectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patel RV, Clark LN, Lebwohl M, Weinberg JM. Treatments for psoriasis and the risk of malignancy. J Am Acad Dermatol 2009;60:1001-17. On page 1002 of the article above, the following statement was incorrect: Patients with mild psoriasis have a relative risk of 1.42 and 3.18 of developing Hodgkin's lymphoma and CTCL, respectively. Patients with severe psoriasis have a relative risk of 4.10 and 10.75 of developing Hodgkin's lymphoma and CTCL, respectively. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 19, 2009 Category: Dermatology Tags: Corrections Source Type: journals

Cells That Control Inflammation In Chronic DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new type of immune cell that can be out of control in certain chronic inflammatory diseases, worsening the symptoms of conditions like psoriasis and asthma, is described for the first time this week in the Journal of Clinical Investigation. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Cells That Control Inflammation In Chronic DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new type of immune cell that can be out of control in certain chronic inflammatory diseases, worsening the symptoms of conditions like psoriasis and asthma, is described for the first time this week in the Journal of Clinical Investigation. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news

Methotrexate versus traditional Chinese medicine in psoriasis: a randomized, placebo-controlled trial to determine efficacy, safety and quality of lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Our results verify the therapeutic effect of methotrexate for the management of psoriasis. Despite widespread belief and use of TCM in Asia for the treatment of psoriasis, we were unable to confirm the efficacy of TCM in this study. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - November 19, 2009 Category: Dermatology Authors: S. G. Y. Ho, C. K. Yeung, H. H. L. Chan Source Type: journals

Estimation of cost-of-illness in patients with psoriasis in Switzerland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Moderate-to-severe psoriasis is associated with a significant impact on the quality of life and at least 4-fold higher costs than mild psoriasis, indicating the need for efficient control of the disease. This cost-of-illness study provides specific health economic data for future healthcare decision making, particularly with the advent of new therapeutic agents for effective psoriasis control. PMID: 19924580 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Navarini AA, Laffitte E, Conrad C, Piffaretti P, Brock E, Ruckdaeschel S, Trüeb RM Tags: Swiss Med Wkly Source Type: journals

Impact of Adalimumab on Symptoms of Psoriatic Arthritis in Patients with Moderate to Severe Psoriasis: A Pooled Analysis of Randomized Clinical TrialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dermatology (DOI:10.1159/000260371) (Source: Dermatology)
Source: Dermatology - November 18, 2009 Category: Dermatology Source Type: journals

Basilea's Toctino(R) Receives Marketing Authorization In CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Basilea Pharmaceutica Ltd. announces that Toctino® (alitretinoin), a new once-daily oral treatment for adults with severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids, has obtained regulatory approval from Health Canada. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Eczema / psoriasis Source Type: news

Basilea's Toctino(R) Receives Marketing Authorization In CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Basilea Pharmaceutica Ltd. announces that Toctino® (alitretinoin), a new once-daily oral treatment for adults with severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids, has obtained regulatory approval from Health Canada. "We are delighted that Health Canada has approved the use of Toctino for patients with severe chronic hand eczema unresponsive to potent topical steroids. (Source: Dermatology News From Medical News Today)
Source: Dermatology News From Medical News Today - November 18, 2009 Category: Dermatology Tags: Eczema / psoriasis Source Type: news

International Psoriasis Council Hosts Second Educational Symposium To Increase Global Knowledge Of PsoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Beginning Thursday, Nov. 19, 2009, the International Psoriasis Council (IPC) will host its second symposium at Baylor University Medical Center in Dallas. The two-day conference brings together dermatologists from Asia, Eastern Europe and Spain to elevate the global understanding of psoriasis and its treatment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Eczema / psoriasis Source Type: news

International Psoriasis Council Hosts Second Educational Symposium To Increase Global Knowledge Of PsoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Beginning Thursday, Nov. 19, 2009, the International Psoriasis Council (IPC) will host its second symposium at Baylor University Medical Center in Dallas. The two-day conference brings together dermatologists from Asia, Eastern Europe and Spain to elevate the global understanding of psoriasis and its treatment. Sessions will be facilitated by leading dermatologists and nurses dedicated to psoriasis management and research. (Source: Dermatology News From Medical News Today)
Source: Dermatology News From Medical News Today - November 18, 2009 Category: Dermatology Tags: Eczema / psoriasis Source Type: news

[Atopic Dermatitis and Psoriasis: What is the Benefit of In-Patient High Altitude Climate Therapy?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atopic dermatitis as well as psoriasis are characterized as common, chronic, often long lasting disorders of the cutis. In case of (a) a refractory out-patient therapy, (b) an acute severe exacerbation of skin lesions, (c) functional impairment of hands and feet, (d) suberythroderma or erythroderma, (e) complex topical as well as systemic treatment modalities, (f) complicating somatic or psychological co-morbidity, a referral to in-patient treatment at high altitude must be considered. The therapy at the Hochgebirgsklinik Davos (1'560 m above see level) is characterized by application of natural-borne UV radiation all ...
Source: Praxis - November 18, 2009 Category: Journals (General) Authors: Steiner C Tags: Praxis (Bern 1994) Source Type: journals

Epidemiology and comorbidity of psoriasis in children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Psoriasis is a common disease in children. Like in adults, it is associated with significant comorbidity. Increased attention should be paid to the early detection and treatment of patients affected. PMID: 19922529 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 18, 2009 Category: Dermatology Authors: Augustin M, Glaeske G, Radtke MA, Christophers E, Reich K, Schäfer I Tags: Br J Dermatol Source Type: journals

Psoriasis and alcohol: is cutaneous ethanol one of the missing links?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Many exogenous factors including excessive alcohol consumption have been associated with psoriasis, but the underlying mechanisms still remain elusive. Drinking worsens therapeutic compliance, decreases the efficacy and increases the toxicity of systemic antipsoriatic treatments. Excess alcohol intake results in compromised immunity and increased risk of infections, but alcohol can induce proinflammatory cytokine production in various cell types and can increase mitogen-derived lymphocyte proliferation and lymphocyte activation. As we have previously reported, alcohol and one of its metabolites acetone induce ...
Source: The British Journal of Dermatology - November 18, 2009 Category: Dermatology Authors: Farkas A, Kemény L Tags: Br J Dermatol Source Type: journals

Scientists discover cells that control inflammation in chronic diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Imperial College London) A new type of immune cell that can be out of control in certain chronic inflammatory diseases, worsening the symptoms of conditions like psoriasis and asthma, is described for the first time this week in the Journal of Clinical Investigation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 17, 2009 Category: Global & Universal Source Type: news

Scientists discover cells that control inflammation in chronic diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New kind of immune cell can go out of control in diseases like psoriasis and asthma - News Release (Source: Imperial College News)
Source: Imperial College News - November 17, 2009 Category: Biomedical Science Source Type: organizations

Linking Publication About Efalizumab Effectiveness With Safety Concerns [Correspondence]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of Dermatology)
Source: Archives of Dermatology - November 16, 2009 Category: Dermatology Tags: Neurology, Neurology, Other, Dermatology, Dermatologic Disorders, Quality of Care, Patient Safety/ Medical Error, psoriasis, Dermatologic Disorders, Other, Drug Therapy, Adverse Effects, Drug Therapy, Other Correspondence Source Type: journals

Leflunomide in the Treatment of Palmoplantar Pustulosis [The Cutting Edge]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of Dermatology)
Source: Archives of Dermatology - November 16, 2009 Category: Dermatology Authors: Melwani, P. M., Penate, Y., Guillermo, N., Soler, E., Hernandez-Machin, B., Borrego, L. Tags: Dermatology, Dermatologic Disorders, psoriasis, Dermatologic Disorders, Other, Drug Therapy, Drug Therapy, Other The Cutting Edge Source Type: journals

Alefacept for Severe Alopecia Areata: A Randomized, Double-blind, Placebo-Controlled Study [Study]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Alefacept is ineffective for the treatment of severe AA. (Source: Archives of Dermatology)
Source: Archives of Dermatology - November 16, 2009 Category: Dermatology Authors: Strober, B. E., Menon, K., McMichael, A., Hordinsky, M., Krueger, G., Panko, J., Siu, K., Lustgarten, J. L., Ross, E. K., Shapiro, J. Tags: Dermatology, Dermatologic Disorders, Alopecia, Hair Disorders, Randomized Controlled Trial, Drug Therapy, Drug Therapy, Other Study Source Type: journals

Psoriatic arthritis in AsiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Geographic or ethnic differences in the occurrence of disease often provide insights into causes of disease and possible opportunities for disease prevention. A wide variation on the incidence and prevalence of PsA was reported in different countries. The prevalence in China was similar to the rest of the world, whereas the incidence and prevalence of PsA was much lower in Japan. Among patients with psoriasis, 6–42% of the Caucasians were reported to have PsA, but figures were lower from Asian countries (1–9%). Divergent distribution of HLA in different ethnic groups and other genetic determinants may account f...
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Tam, L.-S., Leung, Y.-Y., Li, E. K. Tags: Spondylarthropathies REVIEWS Source Type: journals

TNF{alpha} shedding and epidermal inflammation are controlled by Jun proteins [Research Papers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inducible epidermal deletion of JunB and c-Jun in adult mice causes a psoriasis-like inflammatory skin disease. Increased levels of the proinflammatory cytokine TNF play a major role in this phenotype. Here we define the underlying molecular mechanism using genetic mouse models. We show that Jun proteins control TNF shedding in the epidermis by direct transcriptional activation of tissue inhibitor of metalloproteinase-3 (TIMP-3), an inhibitor of the TNF-converting enzyme (TACE). TIMP-3 is down-regulated and TACE activity is specifically increased, leading to massive, cell-autonomous TNF shedding upon loss of both JunB and ...
Source: Genes and Development - November 16, 2009 Category: Genetics & Stem Cells Authors: Guinea-Viniegra, J., Zenz, R., Scheuch, H., Hnisz, D., Holcmann, M., Bakiri, L., Schonthaler, H. B., Sibilia, M., Wagner, E. F. Tags: Research Papers Source Type: journals

Nail Psoriasis: Clinical Presentation and Best Practice RecommendationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Drugs)
Source: Drugs - November 16, 2009 Category: Drugs & Pharmacology Authors: Edwards, FelicityDavid de Berker, Tags: Therapy In Practice Source Type: journals

Using 'number needed to treat' to express the magnitudes of benefit of ultraviolet B phototherapy and of antitumour necrosis factor-α therapies for psoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 16, 2009 Category: Dermatology Authors: R.S. Dawe Source Type: journals

Using 'number needed to treat' to express the magnitudes of benefit of ultraviolet B phototherapy and of antitumour necrosis factor-alpha therapies for psoriasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19919632 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 16, 2009 Category: Dermatology Authors: Dawe RS Tags: Br J Dermatol Source Type: journals

Psoriasis treatment guidelines proposed for patients with concomitant HCVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - November 14, 2009 Category: Dermatology Source Type: news

Psoriasis treatment guidelines proposed for patients with concomitant HCVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Psoriasis)
Source: MedWire News - Psoriasis - November 14, 2009 Category: Dermatology Source Type: news

Homeopathic and conventional therapies for chronic skin diseases: A prospective study on effectiveness and safetyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The treatment of chronic skin diseases with homeopathic remedies appears to be more safe and satisfactory to the patient when compared with conventional medication, with improvement in quality of life and general health up to 2 years after start of the treatment. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: M. Jong Source Type: journals

Evidence based integrative medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Integrative approaches have played an essential role in the treatment of dermatological diseases since a long time. Many current standard treatments can be considered integrative such as phototherapy, climate therapy (such as staying at high altitude or at the sea), special training on how to handle a disease, special diets and psychological approaches. Furthermore the amount of well-controlled studies on complementary medicine in the treatment of dermatological disorders has increased within the last years. Besides different therapies derive from natural remedies, such as fumaric acid or psoralene (used e.g. in the treatm...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: F. Pfab, J. Huss-Marp, H. Behrendt, U. Darsow, J. Ring Source Type: journals

Adalimumab in the management of palmoplantar psoriasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Palmoplantar pustular psoriasis (PPP) is an uncommon form of chronic psoriasis. Characterized by sterile, intraepidermal pustules located on the palms and soles, it is highly resistant to treatment. Our patient presented with palmar inflammation and throbbing joint pain in his hands, as well as erythematous, pustular, and micaceous scaling skin on his right foot, legs, elbows, and hands. Approximately 4 percent of his body surface area was involved and he was diagnosed with PPP after skin biopsy. After conventional therapy failed, the patient underwent treatment with adalimumab and the majority of his symptoms resolved...
Source: Dermatol Online J - November 13, 2009 Category: Dermatology Authors: Ghate JV, Alspaugh CD Tags: Dermatol Online J Source Type: journals

Evidence-based (S3) guideline for the treatment of psoriasis vulgaris – Update: "Therapeutic options" and "Efalizumab"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In February 2009, the European Medicines Agency's (EMEA) Committee for Medicinal Products for Human Use (CHMP) had recommended the suspension of efalizumab's (Raptiva®) marketing authorization, because its benefits in the treatment of psoriasis were modest, while there was a risk of serious side effects in patients receiving the medicine, including the occurrence of progressive multifocal leukoencephalopathy (PML). The guideline group has changed the guideline accordingly. (Source: JDDG)
Source: JDDG - November 13, 2009 Category: Dermatology Authors: Alexander Nast, Matthias Augustin, Wolf-Henning Boehncke, Joachim Klaus, Ulrich Mrowietz, Hans-Michael Ockenfels, Sandra Philipp, Kristian Reich, Thomas Rosenbach, Martin Schlaeger, Michael Sebastian, Wolfram Sterry, Volker Streit, Peter Weisenseel, Berth Source Type: journals

Ustekinumab: new option for moderate-to-severe psoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ustekinumab (Stelara), a novel biologic for the treatment of moderate-to-severe plaque psoriasis, targets interleukins rather than TNF-alpha. In our New products review, Steve Chaplin presents the clinical data relating to its efficacy and adverse effects and Dr Downs discusses its place in psoriasis treatment. Copyright © 2009 Wiley Interface Ltd (Source: Prescriber)
Source: Prescriber - November 13, 2009 Category: Primary Care Authors: Steve Chaplin, Tony Downs Tags: New Products Source Type: journals

Apolipoprotein ε4 allele is associated with psoriasis severityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Many reports provided strong evidence of the influence of genetic factors in the pathogenesis of psoriasis (Ps). A higher prevalence of lipid disorders in psoriatic patients has been reported. Because apolipoprotein E (apoE) is involved in lipid metabolism, APOE gene variants could be candidates to influence Ps-risk. However, data about the potential influence of the APOE genotypes in Ps are inconclusive. Our objective was to investigate the relationship between the common APOE-ε2/ε3/ε4 variation and Ps in a Caucasian population. Our study involved 331 unrelated Ps-patients and 400 healthy controls...
Source: Archives of Dermatological Research - November 12, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Adalimumab safety and mortality rates from global clinical trials of six immune-mediated inflammatory diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based on 10 years of clinical trial experience across six diseases, this safety report and the established efficacy of adalimumab in these diseases provide the foundation for a better understanding of its benefit–risk profile. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 12, 2009 Category: Rheumatology Authors: Burmester, G R, Mease, P, Dijkmans, B A C, Gordon, K, Lovell, D, Panaccione, R, Perez, J, Pangan, A L Tags: Unlocked, Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology, Calcium and bone Clinical and epidemiological research Source Type: journals

Ankylosing spondylitis and the risk of fracture: results from a large primary care-based nested case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients with AS have an increased risk of clinical vertebral fracture but not of non-vertebral fractures, while the risk of any clinical fracture is increased in patients with concomitant inflammatory bowel disease. The mechanism by which non-steroidal anti-inflammatory drugs reduce the risk of any clinical fracture warrants further research. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 12, 2009 Category: Rheumatology Authors: Vosse, D, Landewe, R, van der Heijde, D, van der Linden, S, van Staa, T-P, Geusens, P Tags: Inflammatory bowel disease, Immunology (including allergy), Pain (neurology), Ankylosing spondylitis, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoi Source Type: journals

Generalized pustular psoriasis of pregnancy successfully treated with cyclosporineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hazarika DebeekaIndian Journal of Dermatology, Venereology, and Leprology 2009 75(6):638-638Two multigravidae aged 27 and 29 years, with previous uneventful pregnancies, second being psoriatic, reported at 24 and 28 weeks of pregnancies, with generalized pustular lesions. Laboratory findings, including serum calcium were normal. Ultrasonography showed normal fetal growth. Histopathology confirmed pustular psoriasis. Patients were put on cyclosporine 3 mg/ kg weight/ day after failure of an initial systemic steroid. Blood pressure, pulse, and fetal heart sounds were recorded every 12 hours, and ultrasonography and blood par...
Source: Indian Journal of Dermatology, Venereology and Leprology - November 12, 2009 Category: Dermatology Authors: Hazarika Debeeka Source Type: journals

Increased Serum Levels of Growth-Related Oncogene-a in Patients with Generalized Pustular PsoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dermatology (DOI:10.1159/000258674) (Source: Karger Publishers)
Source: Karger Publishers - November 11, 2009 Category: Cancer & Oncology Source Type: journals

Reliability, Validity, and Responsiveness to Change of the Patient Report of Extent of Psoriasis Involvement (PREPI) for Measuring Body Surface Area Affected by Psoriasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study suggests that the PREPI is a reliable, valid, and responsive measure of body surface area affected by psoriasis that may be useful for future epidemiologic research. PMID: 19906216 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 11, 2009 Category: Dermatology Authors: Dommasch ED, Shin DB, Troxel AB, Margolis DJ, Gelfand JM Tags: Br J Dermatol Source Type: journals

Basement membrane antibodies in sera of haematopoietic cell recipients are associated with graft-versus-host diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Circulating BMZ antibodies are significantly associated with chronic GvHD in contrast to uncomplicated HCT. Recurrent mucocutaneous lesions in chronic inflammatory skin disorders may liberate antigens, which may lead to production of BMZ antibodies, particularly in the context of GvHD-mediated reduced self-tolerance. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - November 10, 2009 Category: Dermatology Authors: SC Hofmann, G Kopp, C Gall, L Bruckner-Tuderman, H Bertz Source Type: journals

TCRgamma gene rearrangement in cutaneous T-cell lymphoma: comparative study of PCR with denaturing gradient gel electrophoresis and GeneScan analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions BIOMED-2-GS analysis of the TCRgamma gene is as sensitive and specific as DGGE for CTCL diagnosis. In addition, BIOMED-2-GS is less time-consuming and gives more information concerning the size and nature of TCR-GR. PMID: 19906072 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 10, 2009 Category: Dermatology Authors: Goeldel AL, Cornillet-Lefebvre P, Durlach A, Birembaut P, Bernard P, Nguyen P, Grange F Tags: Br J Dermatol Source Type: journals

Infliximab for the treatment of psoriasis in Greece. Four years of clinical experience at a single center.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The above data confirm previous reports that treatment with infliximab is an efficacious and safe option for patients with moderate to severe plaque psoriasis (and/or arthritis). Long-term follow-up, continued pharmacovigilance, and controlled comparative studies will be required to fully evaluate its use in psoriasis. PMID: 19906069 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 10, 2009 Category: Dermatology Authors: Antoniou C, Stefanaki I, Stratigos A, Moustou E, Vergou T, Stavropoulos P, Avgerinou G, Rigopoulos D, Katsambas AD Tags: Br J Dermatol Source Type: journals

Daily practice assessment of liver injury in patients with psoriasis on methotrexateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 9, 2009 Category: Dermatology Authors: R.J.B. Driessen, P.C.M. van de Kerkhof, E.M.G.J. de Jong Source Type: journals

Ustekinumab improves health-related quality of life in patients with moderate-to-severe psoriasis: results from the PHOENIX 1 trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Ustekinumab improves HRQoL in patients with moderate-to-severe psoriasis. Patient-reported outcomes measured a treatment effect beyond that indicated by clinical measures. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 9, 2009 Category: Dermatology Authors: M. Lebwohl, K. Papp, C. Han, B. Schenkel, N. Yeilding, Y. Wang, G.G. Krueger Source Type: journals

Ustekinumab improves health-related quality of life in patients with moderate-to-severe psoriasis: results from the PHOENIX 1 trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Ustekinumab improves HRQoL in patients with moderate-to-severe psoriasis. Patient-reported outcomes measured a treatment effect beyond that indicated by clinical measures. PMID: 19903183 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 9, 2009 Category: Dermatology Authors: Lebwohl M, Papp K, Han C, Schenkel B, Yeilding N, Wang Y, Krueger GG Tags: Br J Dermatol Source Type: journals

Daily practice assessment of liver injury in patients with psoriasis on methotrexate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19903179 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 9, 2009 Category: Dermatology Authors: Driessen RJ, van de Kerkhof PC, de Jong EM Tags: Br J Dermatol Source Type: journals

Linear psoriasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 33-year-old man presented with verrucous, red-brown papules, which coalesced into linear plaques on the right buttock, waist, thigh, and genitals. A skin biopsy was consistent with psoriasis, and the unilateral distribution in a linear pattern led to a diagnosis of linear psoriasis, which is a rare variant of psoriasis. Although histopathologically it can be difficult to distinguish from inflammatory linear verrucous epidermal nevus (ILVEN), linear psoriasis presents in adulthood and responds to conventional topical antipsoriatic therapies. PMID: 19891912 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - November 7, 2009 Category: Dermatology Authors: Chien P, Rosenman K, Cheung W, Wang N, Sanchez M Tags: Dermatol Online J Source Type: journals