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Angiostrongylus cantonensis Infection in Brown Rats (Rattus norvegicus), Atlanta, Georgia, USA, 2019-2022
Emerg Infect Dis. 2023 Oct;29(10):2167-2170. doi: 10.3201/eid2910.230706.ABSTRACTRat lungworm (Angiostrongylus cantonensis), a zoonotic parasite invasive to the United States, causes eosinophilic meningoencephalitis. A. cantonensis harbors in rat reservoir hosts and is transmitted through gastropods and other paratenic hosts. We discuss the public health relevance of autochthonous A. cantonensis cases in brown rats (Rattus norvegicus) in Atlanta, Georgia, USA.PMID:37735783 | DOI:10.3201/eid2910.230706
Source: Emerging Infectious Diseases - September 22, 2023 Category: Infectious Diseases Authors: Nicole L Gottdenker Rafael Antonio Nascimento Ramos Hassan Hakimi Brittany McHale Sam Rivera Bryce M Miller Elizabeth W Howerth Caitlin E Burrell Justin M Stilwell Rita McManamon Guilherme G Verocai Source Type: research

ctDNA-guided adjuvant treatment after radical-intent treatment of metastatic spread from colorectal cancer-the first interim results from the OPTIMISE study
CONCLUSION: The study was proven to be feasible and continues in the planned large-scale phase II trial. Results from the OPTIMISE study will potentially optimize the adjuvant treatment of patients undergoing radical-intent treatment of mCRC, thereby improving survival and reducing chemotherapy-related toxicity.PMID:37738268 | DOI:10.1080/0284186X.2023.2259083
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Louise Bach Callesen Torben Fr østrup Hansen Rikke Fredslund Andersen Niels Pallisgaard Stine Kramer Sven Schlander S øren Rafael Rafaelsen Anders Kindberg Boysen Lars Henrik Jensen Anders Jakobsen Karen-Lise Garm Spindler Source Type: research

Safety and efficacy of benralizumab in elderly subjects with severe asthma
CONCLUSIONS: In patients aged >65 years old, benralizumab was an effective and safe therapy for severe eosinophilic asthma in our study, with no significant differences from the younger subgroup. This is especially important since they are a group with numerous comorbidities, medications and worse quality of life.PMID:37737844 | DOI:10.1080/02770903.2023.2263078
Source: Journal of Asthma - September 22, 2023 Category: Respiratory Medicine Authors: Marcela Valverde-Monge Remedios C árdenas Ismael Garc ía-Moguel Ana Rosado Mar Gandolfo-Cano Teresa Robledo Echarren Mar ía Del Mar Moro-Moro Mar ía Del Mar Reaño Martos Rafael Pineda-Pineda Cristina Martin-Arriscado Arroba Javier Dom ínguez-Ortega Source Type: research

ctDNA-guided adjuvant treatment after radical-intent treatment of metastatic spread from colorectal cancer-the first interim results from the OPTIMISE study
CONCLUSION: The study was proven to be feasible and continues in the planned large-scale phase II trial. Results from the OPTIMISE study will potentially optimize the adjuvant treatment of patients undergoing radical-intent treatment of mCRC, thereby improving survival and reducing chemotherapy-related toxicity.PMID:37738268 | DOI:10.1080/0284186X.2023.2259083
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Louise Bach Callesen Torben Fr østrup Hansen Rikke Fredslund Andersen Niels Pallisgaard Stine Kramer Sven Schlander S øren Rafael Rafaelsen Anders Kindberg Boysen Lars Henrik Jensen Anders Jakobsen Karen-Lise Garm Spindler Source Type: research

Cutting cartel recruitment could be the only way to reduce Mexico ’s violence
For decades, the Mexican government has been fighting a losing war against dozens of cartels involved in drug trading, human trafficking, extortion, and other crimes. Even though thousands of cartel members land in prison each year, cartel-related violence has continued to grow: The number of homicides resulting from the organizations fighting one another—including thousands of innocent bystanders caught in their crossfire each year—tripled between 2006 and 2018. Now, researchers have developed a mathematical model of cartel recruitment and losses that hints at a better way out of this cycle of violence. The study...
Source: Science of Aging Knowledge Environment - September 21, 2023 Category: Geriatrics Source Type: research

Reducing cartel violence in Mexico, and what to read and see this fall
The key to shrinking cartels is cutting recruitment, and a roundup of books, video games, movies, and more   First up on this week’s show: modeling Mexico’s cartels. Rafael Prieto-Curiel, a postdoctoral research fellow at the Complexity Science Hub in Vienna, joins host Sarah Crespi to discuss how modeling cartel activities can help us understand the impact of potential interventions such as increased policing or reducing gang recruitment.    Lisa Sanchez, executive director of México Unido Contra la Delincuencia, talks with Sarah about just how difficult it would be to make the model results—which show that ...
Source: Science Magazine Podcast - September 21, 2023 Category: Science Authors: Science Magazine Source Type: podcasts

Examining individual learning patterns using generalised linear mixed models
Behav Res Methods. 2023 Sep 20. doi: 10.3758/s13428-023-02232-z. Online ahead of print.ABSTRACTEveryone learns differently, but individual performance is often ignored in favour of a group-level analysis. Using data from four different experiments, we show that generalised linear mixed models (GLMMs) and extensions can be used to examine individual learning patterns. Producing ellipsoids and cluster analyses based on predicted random effects, individual learning patterns can be identified, clustered and used for comparisons across various experimental conditions or groups. This analysis can handle a range of datasets inclu...
Source: Behavior Research Methods - September 21, 2023 Category: Psychiatry & Psychology Authors: Sean Commins Antoine Coutrot Michael Hornberger Hugo J Spiers Rafael De Andrade Moral Source Type: research

Conduction system pacing and atrioventricular node ablation in heart failure: The PACE ‐FIB study design
ConclusionLBBP is a promising stimulation mode that may foster the clinical benefit of heart rate regularization through AV node ablation compared with pharmacological rate control. This is the first randomized trial specifically addressing the long-term efficacy and safety of this pace-and-ablate strategy in patients with HFpEF/HFmrEF and permanent AF.
Source: ESC Heart Failure - September 21, 2023 Category: Cardiology Authors: Daniel Rodr íguez Muñoz, María Generosa Crespo‐Leiro, Ignacio Fernández Lozano, José Luis Zamorano Gómez, Rafael Peinado Peinado, Luis Manzano Espinosa, Javier Juan Bagudá, Álvaro Marco del Castillo, Fernando Arribas Ynsaurriaga, Rafael Tags: Study Design Source Type: research

Noncardiac comorbidities and intensive up ‐titration of oral treatment in patients recently hospitalized for heart failure: insights from the STRONG‐HF trial
ConclusionsIn the STRONG-HF trial, non-cardiac comorbidities neither limited the rapid up-titration of HF-therapies, nor attenuated the benefit of HIC on primary endpoint.In the context of a clinical trial, the benefit-risk ratio favors the rapid up-titration of HF-therapies even in patients with multiple NCCsThis article is protected by copyright. All rights reserved.
Source: European Journal of Heart Failure - September 21, 2023 Category: Cardiology Authors: Ovidiu Chioncel, Beth Davison, Marianna Adamo, Laura E Antohi, Mattia Arrigo, Marianela Barros, Jan Biegus, Kamil ė Čerlinskaitė‐Bajorė, Jelena Celutkiene, Alain Cohen‐Solal, Albertino Damasceno, Rafael Diaz, Christopher Edwards, Gera Tags: Research Article Source Type: research

Aberration-free holographic microscope for simultaneous imaging and stimulation of neuronal populations
A technical challenge in neuroscience is to record and specifically manipulate the activity of neurons in living animals. This can be ...
Source: Optics Express - September 21, 2023 Category: Physics Authors: Yuriy Shymkiv Rafael Yuste Source Type: research

An Experimental and Computational Investigation of the Elusive Anhydrous form of Oxyma-B
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Rafel Prohens, Rafael Barbas, Beatriz G. de la Torre, Fernando Albericio, Antonio Frontera We report the crystal structure of the anhydrous form of Oxyma-B, a relevant racemization suppressor for peptide synthesis, solved by direct space methodologies from X-Ray Powder Diffraction Data. The structure... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - September 20, 2023 Category: Chemistry Authors: Rafel Prohens Source Type: research

First report of Aedes albopictus (Diptera: Culicidae) in the North of Colombia
Rev Inst Med Trop Sao Paulo. 2023 Sep 15;65:e49. doi: 10.1590/S1678-9946202365049. eCollection 2023.ABSTRACTAedes albopictus is considered a potential vector of arboviruses in Colombia. Females and males naturally infected with dengue, Zika and chikungunya viruses have already been found in this country. We document the first record of Ae. albopictus in the Cordoba department, in North of Colombia. The finding was carried out during Ae. aegypti collection activities in the Ayapel, Montelibano, Planeta Rica, Pueblo Nuevo and Puerto Libertador municipalities. The entomological material was collected in water containers such ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - September 20, 2023 Category: Tropical Medicine Authors: Mar ía Claudia Atencia-Pineda Alfonso Calder ón-Rangel Richard Hoyos-L ópez Javier Garc ía-Leal Rafael Bola ños Paula Pareja-Loaiza Ronald Maestre-Serrano Source Type: research

Environmental characterization of home range of Antillean manatees (Trichechus manatus) released in northeastern Brazil
This study characterized the home range areas of six rehabilitated manatees released in northeastern Brazil. The activities were conducted in the states of Paraíba, Sergipe, and Bahia. Type of environment, substrate, depth, aquatic vegetation, physicochemical variables of the water, presence of solid waste, human settlements, and watercraft were considered to characterize the areas. The results showed a manatee preference for sheltered areas. Resources were available in larger quantities in the dry season, and a reduction in the availability of food items was fund over the years. High overlap was found in the multivariate...
Source: An Acad Bras Cienc - September 20, 2023 Category: Science Authors: Sebasti ão S Dos Santos Iara S Medeiros Isis C DE Almeida Vanessa A Rebelo Allan O B Carvalho Rafael Menezes Miriam Marmontel Jo ão Carlos G Borges Source Type: research

Conserving avian evolutionary history can effectively safeguard future benefits for people
Sci Adv. 2023 Sep 22;9(38):eadh4686. doi: 10.1126/sciadv.adh4686. Epub 2023 Sep 20.ABSTRACTPhylogenetic diversity (PD)-the evolutionary history of a set of species-is conceptually linked to the maintenance of yet-to-be-discovered benefits from biodiversity or "option value." We used global phylogenetic and utilization data for birds to test the PD option value link, under the assumption that the performance of sets of PD-maximizing species at capturing known benefits is analogous to selecting the same species at a point in human history before these benefits were realized. PD performed better than random at capturing utili...
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Rikki Gumbs Claudia L Gray Michael Hoffmann Rafael Molina-Venegas Nisha R Owen Laura J Pollock Source Type: research

Validated HPLC-UV method for amphotericin B quantification in a critical patient receiving AmBisome and treated with extracorporeal replacement therapies
Biomed Chromatogr. 2023 Sep 20:e5749. doi: 10.1002/bmc.5749. Online ahead of print.ABSTRACTAmphotericin B (AMB) is a polyene macrolide antifungal agent used for treating invasive fungal infections. Liposomal AMB is a lipid dosage form, available as AmBisome, which reduces the toxicity of the drug. A simple HPLC-UV method was developed for the determination of AMB in plasma to study its pharmacokinetic profile in a critical patient receiving AmBisome and treated with extracorporeal replacement therapies. Sample preparation was performed using plasma deproteinization and drug release from liposome by the addition of acetonit...
Source: Biomedical Chromatography : BMC - September 20, 2023 Category: Biomedical Science Authors: Carlos Ezquer-Garin Gerardo Aguilar Rafael Ferriols-Lisart Manuel Alos-Almi ñana Source Type: research