Cancers, Vol. 16, Pages 1652: Exosome-Mediated Paracrine Signaling Unveils miR-1246 as a Driver of Aggressiveness in Fusion-Negative Rhabdomyosarcoma
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Sandra E. Ghayad
Rhabdomyosarcoma is a pediatric cancer associated with aggressiveness and a tendency to develop metastases. Fusion-negative rhabdomyosarcoma (FN-RMS) is the most commonly occurring subtype of RMS, where metastatic disease can hinder treatment success and decrease survival rates. RMS-derived exosomes were previously demonstrated to be enriched with miRNAs, including miR-1246, possibly contributing to disease aggressiveness. We aimed to decipher the functional impact of exosomal miR-1246 on recipient cells and its role in promoting aggressiveness. Treatment of normal fibroblasts with FN-RMS-derived ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Farah Ramadan Raya Saab Farah Ghamloush Rita Khoueiry Zdenko Herceg Ludovic Gomez Bassam Badran Philippe Clezardin Nader Hussein Pascale A. Cohen Sandra E. Ghayad Tags: Article Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Multimodality Imaging Evaluation of Nasal Rhabdomyosarcoma in Adults: A Case Report and Literature Review
CONCLUSION: Sinus ARMS is notably malignant and associated with a dismal prognosis. Accurate diagnosis depends on histopathological and immunohistochemical evaluation, complemented by genetic analysis for specific chromosomal translocations and fusion genes. Imaging techniques, including CT, MRI, and PET/CT, are crucial for assessing lesion extent and metastasis, supporting disease diagnosis, informing treatment choices, facilitating surgical planning, and monitoring response to therapy.PMID:38644703 | DOI:10.2174/0118744710288830240405090932 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 22, 2024 Category: Radiology Authors: Lujiao Chen Bo Chen Shanlu Yu Zhenhua Zhao Liyijing Shen Source Type: research
Mosaic RASopathies concept: different skin lesions, same systemic manifestations?
Conclusion
This review delineates genotype/phenotype correlations of syndromic epidermal nevi with somatic RAS and BRAF pathogenic variants and may help improve their follow-up. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - April 19, 2024 Category: Genetics & Stem Cells Authors: Morren, M.-A., Fodstad, H., Brems, H., Bedoni, N., Guenova, E., Jacot-Guillarmod, M., Busiah, K., Giuliano, F., Gilliet, M., Atallah, I. Tags: Genotype-phenotype correlations Source Type: research
Non-surgical fertility spearing management of cervical embryonal rhabdomyosarcoma
J Obstet Gynaecol Can. 2024 Apr 15:102462. doi: 10.1016/j.jogc.2024.102462. Online ahead of print.NO ABSTRACTPMID:38631432 | DOI:10.1016/j.jogc.2024.102462 (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - April 17, 2024 Category: OBGYN Authors: Nesrine Souayeh Manel Ben Ghalia Hadhemi Rouis Hajer Bettaieb Source Type: research
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma [Errata]
(Source: Genes and Development)
Source: Genes and Development - April 17, 2024 Category: Genetics & Stem Cells Authors: Langenau, D. M., Keefe, M. D., Storer, N. Y., Guyon, J. R., Kutok, J. L., Le, X., Goessling, W., Neuberg, D. S., Kunkel, L. M., Zon, L. I. Tags: Errata Source Type: research
Novel small molecule DMAMCL induces differentiation in rhabdomyosarcoma by downregulating of DLL1
This study unveils a novel anti-tumor mechanism of dimethylaminomicheliolide (DMAMCL), which is a water-soluble derivative of Micheliolide. First, we demonstrate that DMAMCL inhibits RMS cell growth without obvious cell death, leading to morphological alterations, enhanced expression of muscle differentiation markers, and a shift from a malignant to a more benign metabolic phenotype. Second, we detected decreased expression of DLL1 in RMS cells after DMAMCL treatment, known as a pivotal ligand in the Notch signaling pathway. Downregulation of DLL1 inhibits RMS cell growth and induces morphological changes similar to the ef...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 16, 2024 Category: Drugs & Pharmacology Authors: Qi Li Yexi Chen Yang Chen Zhongyan Hua Baocheng Gong Zhihui Liu Carol J Thiele Zhijie Li Source Type: research
Primary Alveolar Rhabdomyosarcoma of the Thyroid: A Case Report
We present the case of an adolescent who presented with a neck mass and suffered rapid deterioration. Establishment of final diagnosis was possible only because of a skilfully performed pathological examination which revealed a thyroid gland rhabdomyosarcoma. An alveolar variety of rhabdomyosarcoma presenting in the thyroid gland is extremely rare. To the best of our knowledge, only two cases of the aforementioned are documented as yet. Through this report, we aim at highlighting the possibility of such an occurrence and vigilance on part of the treating surgeon so that timely intervention can be instituted. (Source: India...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 12, 2024 Category: ENT & OMF Source Type: research
< em > NF1 < /em > -Driven Rhabdomyosarcoma Phenotypes: A Comparative Clinical and Molecular Study of < em > NF1 < /em > -Mutant Rhabdomyosarcoma and < em > NF1 < /em > -Associated Malignant Triton Tumor
CONCLUSION: Patients with NF1-mutant ERMS lacking TP53 alterations may benefit from dose-reduction chemotherapy. On the basis of the diagnostic challenges and significant treatment and prognostic differences, molecular profiling of challenging tumors with rhabdomyoblastic differentiation is recommended.PMID:38603649 | DOI:10.1200/PO.23.00597 (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Henry de Traux de Wardin Josephine K Dermawan Fabio Vanoli Samuel C Jiang Samuel Singer Ping Chi William Tap Leonard H Wexler Cristina R Antonescu Source Type: research
Paratesticular spindle cell rhabdomyosarcoma: A case report
Asian J Surg. 2024 Apr 10:S1015-9584(24)00607-9. doi: 10.1016/j.asjsur.2024.03.180. Online ahead of print.NO ABSTRACTPMID:38604842 | DOI:10.1016/j.asjsur.2024.03.180 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Yifei Hong Tongtong Wang Li Li Source Type: research
Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines
CONCLUSIONS: Consensus guidelines for the use of brachytherapy in pediatric rhabdomyosarcoma have been developed through multicenter collaboration establishing the basis for future work. These have been adopted for the open EpSSG overarching study for children and adults with Frontline and Relapsed RhabdoMyoSarcoma (FaR-RMS).PMID:38588921 | DOI:10.1016/j.radonc.2024.110273 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 8, 2024 Category: Radiology Authors: Raquel D ávila Fajardo Giovanni Scarzello Mark N Gaze Tom Boterberg Alison Cameron Joerg Fuchs Florent Gu érin Peter Hoskin Matthew J Krasin Petra Kroon Henriette Magelssen Claes Mercke Johannes H M Merks Frank Paulsen Pascal Pommier Monica Ramos Helen Source Type: research
