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Total 40893 results found since Jan 2013.

GSE222695 Transcriptomic profiling of CDCP1 knock-down in human cardiac fibroblasts (HCFs)
Contributors : Vishakantha Murthy ; Thanh L Nguyen ; Duan LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of CDCP1 in regulation of HCF proliferation, we cultured primary HCFs and transfected with non-targeting siRNA and CDCP1 siRNAs. Total RNA samples were extracted for RNA-seq to identify transcriptome-wide gene expression changes in the HCFs after CDCP1 knock-down (KD).
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Musclin Mitigates the Attachment of HUVECs to THP-1 Monocytes in Hyperlipidemic Conditions through PPAR α/HO-1-Mediated Attenuation of Inflammation
This study aimed to explore the impact of musclin on inflammatory responses and the interaction between endothelial cells and monocytes under hyperlipidemic conditions. The attachment levels of THP-1 monocytes on cultured HUVECs were examined. Inflammation and the expression of cell adhesion molecules were also evaluated. To explore the molecular mechanisms of musclin, PPAR α or heme oxygenase 1 (HO-1) siRNA transfection was performed in HUVECs. The results revealed that treatment with recombinant musclin effectively suppressed the attachment of palmitate-induced HUVECs to THP-1 cells and reduced the expression of cell ad...
Source: Inflammation - September 22, 2023 Category: Allergy & Immunology Source Type: research

In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06159-3In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Lingfeng Yu Gentao Fan Qingyan Wang Yan Zhu Hao Zhu Jiang Chang Zhen Wang Shoubin Zhan Xianming Hua Diankun She Jianhao Huang Yicun Wang Jianning Zhao Chen-Yu Zhang Xi Chen Guangxin Zhou Source Type: research

Retracted IQGAP1 ‑siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines
Mol Med Rep. 2023 Nov;28(5):207. doi: 10.3892/mmr.2023.13094. Epub 2023 Sep 21.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control western blotting data shown in Fig. 1C, and other western blotting data included in Figs. 2D and 7C and D, were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published elsewhere, prior to its s...
Source: Molecular Medicine Reports - September 21, 2023 Category: Molecular Biology Authors: Bo Diao Ying Liu Yi Zhang Jing Yu Jun Xie Guo-Zheng Xu Source Type: research

Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis
This study was designed to investigate the effects and underlying mechanisms of linc00657 in atherogenesis. The results showed that ox-LDL treatment significantly induced pyroptosis in human THP-1-derived macrophages. The secretion levels of LDH and pro-inflammatory factors were markedly enhanced, and the integrity of plasma membranes was disrupted in ox-LDL-treated THP-1-derived macrophages. These effects were significantly compensated after transfection with linc00657 siRNA and became more evident by linc00657 overexpression. Moreover, the effects of linc00657 overexpression on pyroptosis of THP-1-derived macrophages can...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Yin Liang Xiao-Dan Xu Xi Xu Yang-Bo Cai Zi-Xian Zhu Lin Zhu Kun Ren Source Type: research

EEF1A1 is Involved the Regulating Neuroinflammatory Processes in Parkinson's Disease
CONCLUSIONS: EEF1A1 is involved in the regulating of IL-6, GDF15, STC1, MT1E, GPNMB, CCL5, MT1X, A2M, and VIP genes associated with the neuroinflammatory process of PD. Among them, we found that GDF15, STC1, MT1E, MT1X, GPNMB, VIP, and A2M genes were involved in delaying the neuroinflammatory process of PD, while IL-6 and CCL5 were involved in exacerbating the neuroinflammatory process, implicating that EEF1A1 may participate in the regulation of the PD neuroinflammation.PMID:37735116 | DOI:10.31083/j.jin2205122
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Zaolaguli Aisha Jing Lei Yan Zhang Jianhua Ma Source Type: research

GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis
ConclusionsGCH1 inhibited ferroptosis in LPS-stimulated macrophages, reduced macrophage toward to M1 polarization and inflammatory response.
Source: Inflammation Research - September 21, 2023 Category: Research Source Type: research

Toxoplasma gondii induces pyroptosis in human placental trophoblast and amniotic cells by inducing ROS production and activation of cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 inflammasome
Toxoplasma gondii infection in pregnant women may cause fetal anomaly; however, the underlying mechanisms remain unclear. Here, we investigated whether T. gondii induces pyroptosis in human placental cells and the underlying mechanisms. Human placental trophoblast (BeWo and HTR-8/SVneo) and amniotic (WISH) cells were infected with T. gondii, and then ROS production, cathepsin B (CatB) release, inflammasome activation, and pyroptosis induction were evaluated. Moreover, the molecular mechanisms of these effects were investigated by treating the cells with ROS scavengers, a CatB inhibitor, or inflammasome-specific siRNA.
Source: American Journal of Pathology - September 21, 2023 Category: Pathology Authors: Juan-Hua Quan, Fei Fei Gao, Tian-Zhong Ma, Wei Ye, Xiang Gao, Ming-Zhu Deng, Lan-Lan Yin, In-Wook Choi, Jae-Min Yuk, Guang-Ho Cha, Young-Ha Lee, Jia-Qi Chu Tags: Regular Article Source Type: research

ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway
In conclusion, this study uncovers the role of ZNF746 in promoting M2 macrophage polarisation and suggests that ZNF746 may be a promising therapeutic target for limiting BC progression.PMID:37730102 | DOI:10.1016/j.cellsig.2023.110892
Source: Cellular Signalling - September 20, 2023 Category: Cytology Authors: Lu Liu Wen-Yue Zhao Xin-Yu Zheng Source Type: research

Downregulated BIRC5 inhibits proliferation and metastasis of melanoma through the β-catenin/HIF-1α/VEGF/MMPs pathway
CONCLUSION: Our findings revealed that ZWZ-3 could downregulate BIRC5 and inhibit melanoma proliferation and metastasis through the β-catenin/HIF-1α/VEGF/MMPs pathway. Therefore, BIRC5 represents a promising therapeutic target for the treatment of melanoma.PMID:37728702 | DOI:10.1007/s00432-023-05425-3
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Qingqing He Yijing He Changqiang Li Jianv Wang Tong Xia Xia Xiong Jixiang Xu Li Liu Source Type: research

LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research

Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research