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Unrecognized tamponade diagnosed pre-induction by focused echocardiography.
CONCLUSION: Focused TTE has significant clinical utility for the diagnosis and assessment of hemodynamically significant cardiac conditions, particularly in the complex patient where clinical examination is challenging and echocardiographic findings can have immediate management implications. PMID: 23681721 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - May 17, 2013 Category: Anesthesiology Authors: Gerlach RM, Saha TK, Allard RV, Tanzola RC Tags: Can J Anaesth Source Type: research

Cerebritis Arising From Acute Sinusitis Evolving Into a Large Brain Abscess
A 13-year-old girl was admitted with headache and fever. She had a previous history of sinusitis, but did not report rhinologic signs. Her neurologic examination findings were normal except mild neck stiffness. Cranial axial computed tomography showed sphenoid sinusitis. Cerebrospinal fluid analysis was normal. Intravenous cefotaxime was administrated to treat sinusitis. However, the symptoms of fever, headache, and neck stiffness persisted. Brain magnetic resonance imaging (MRI), performed after 2 days, identified early stage cerebral abscess extended from sinusitis (). She underwent functional endoscopic sinus surgery, a...
Source: Pediatric Neurology - May 15, 2013 Category: Neurology Authors: Keun Soo Lee, Bo Lyun Lee Tags: Images in Child Neurology Source Type: research

CT Findings of Sinonasal Respiratory Epithelial Adenomatoid Hamartoma: A Closer Look at the Olfactory Clefts [HEAD & NECK]
CONCLUSIONS: Both clinical presentations of REAH are associated with OC widening on CT scan. In the setting of polypoid disease, an OC width of > 10 mm should increase suspicion for the presence of REAH. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - May 15, 2013 Category: Radiology Authors: Hawley, K. A., Ahmed, M., Sindwani, R. Tags: HEAD & amp; NECK Source Type: research

Damage-associated molecular patterns and their receptors in upper airway pathologies.
Abstract Inflammation of the nasal (rhinitis) and sinus mucosa (sinusitis) are prevalent medical conditions of the upper airways that are concurrent in many patients; hence the terminology "rhinosinusitis". The disease status is further defined to be "chronic" in case symptoms persist for more than 12 weeks without resolution. A diverse spectrum of external factors including viral and bacterial insults together with epithelial barrier malfunctions could be implicated in the chronicity of the inflammatory responses in chronic rhinosinusitis (CRS). However, despite massive research efforts in an attempt to unveil th...
Source: Cellular and Molecular Life Sciences : CMLS - May 15, 2013 Category: Cytology Authors: Van Crombruggen K, Jacob F, Zhang N, Bachert C Tags: Cell Mol Life Sci Source Type: research

Impact of synechiae after endoscopic sinus surgery on long‐term outcomes in chronic rhinosinusitis
ConclusionsSynechiae of the sinonasal cavity commonly occurs following ESS, particularly in those undergoing revision surgeries. Although both groups improve, the degree of HRQoL improvement appears to be less in those who form postoperative synechiae after surgery compared to those who do not. Level of Evidence2c. Laryngoscope, 2013 (Source: The Laryngoscope)
Source: The Laryngoscope - May 13, 2013 Category: ENT & OMF Authors: Oswaldo A. Henriquez, Rodney J. Schlosser, Jess C. Mace, Timothy L. Smith, Zachary M. Soler Tags: Allergy/Rhinology Source Type: research

The otolaryngology hospitalist
ConclusionsTo our knowledge, ours is the first full‐time otolaryngology hospitalist model in the United States. The hospitalist practice is a conceptually viable and clinically beneficial paradigm that should be considered at other similar institutions. Level of EvidenceN/A. (Source: The Laryngoscope)
Source: The Laryngoscope - May 10, 2013 Category: ENT & OMF Authors: Matthew S. Russell, David Eisele, Andrew Murr Tags: General Otolaryngology Source Type: research

Isolated sinusitis sphenoidalis caused by Trichoderma longibrachiatum in an immunocompetent patient with headache.
We present a case of isolated sinusitis sphenoidalis caused by Trichoderma longibrachiatum, an emerging causal agent of fungal infections with often fatal outcome. A Trichoderma strain was isolated from secretion obtained from the sinus sphenoidalis of a rhinosinusitis patient and identified by sequence analysis of two loci as Trichoderma longibrachiatum from the Longibrachiatum clade of the genus Trichoderma. T. longibrachiatum can trigger a fatal pathomechanism in immunodeficient patients, while only rarely causes disease in healthy people. The unique character of the present case is that the patient was not immunocompro...
Source: Journal of Medical Microbiology - May 8, 2013 Category: Microbiology Authors: Molnár-Gábor E, Dóczi I, Hatvani L, Vágvölgyi C, Kredics L Tags: J Med Microbiol Source Type: research

Optimal duration of macrolide treatment for chronic sinusitis after endoscopic sinus surgery
Conclusion: The results indicate that chronic sinusitis patients with rhinorrhea or postnasal drip should be treated with macrolides for 6 months after surgery in order to improve the long-term outcome of endoscopic sinus surgery. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - May 1, 2013 Category: ENT & OMF Authors: Yoshihisa Nakamura, Motohiko Suzuki, Makoto Yokota, Shinya Ozaki, Nobuaki Ohno, Yuki Hamajima, Meiho Nakayama, Motoyuki Hashiba, Shingo Murakami Tags: Rhinology Source Type: research

Mechanisms of Aspirin Desensitization
Aspirin-exacerbated respiratory disease is a clinical syndrome characterized by severe, persistent asthma, hyperplastic eosinophilic sinusitis with nasal polyps, and reactions to aspirin and other nonsteroidal antiinflammatory drugs that preferentially inhibit cyclooxygenase 1. The mechanisms behind the therapeutic effects of aspirin desensitization remain poorly understood. Recent studies suggest that the clinical benefits may occur through direct inhibition of tyrosine kinases and the signal transducer and activator of transcription 6 signaling pathway, which results in inhibition of interleukin 4 production. In this art...
Source: Immunology and Allergy Clinics of North America - May 1, 2013 Category: Allergy & Immunology Authors: Trever Burnett, Rohit Katial, Rafeul Alam Source Type: research

Potential adverse events of endosseous dental implants penetrating the maxillary sinus
ConclusionThis long‐term study, spreading over a period of up to 20 years, indicates that no sinus complication was observed following implant penetration into the maxillary sinus. Furthermore, absence of occurrence of such complications is related to the maintenance of successful osseointegration. A contrario, and in the presence of an acute or chronic maxillary sinusitis, the differential diagnosis must always consider other potential odontogenic and nonodontogenic etiologies. Level of Evidence2b (Source: The Laryngoscope)
Source: The Laryngoscope - May 1, 2013 Category: ENT & OMF Authors: Semaan Abi Najm, Didier Malis, Marc El Hage, Sonia Rahban, Jean‐Pierre Carrel, Jean‐Pierre Bernard Tags: Original Reports Source Type: research

Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults
This study evaluated an allergy immunotherapy tablet (AIT; SCH 39641/MK-3641) for treatment of ragweed-induced AR/C in the first large randomized, double-blind multinational trial of this therapeutic modality for ragweed allergy.Methods: Adults (n = 784) with short ragweed-induced AR/C were randomly assigned to approximately 52 weeks of daily self-administered ragweed AIT of 1.5, 6, or 12 units of Ambrosia artemisiifolia major allergen 1 (Amb a 1-U) or placebo. Subjects could use as-needed allergy rescue medication. Symptoms and medications were recorded daily. The primary efficacy end point was total combined daily sym...
Source: Journal of Allergy and Clinical Immunology - April 30, 2013 Category: Allergy & Immunology Authors: Peter S. Creticos, Jennifer Maloney, David I. Bernstein, Thomas Casale, Amarjot Kaur, Robert Fisher, Nancy Liu, Kevin Murphy, Kristóf Nékám, Hendrik Nolte Tags: Rhinitis, sinusitis, and upper airway disease Source Type: research

Go For The Glory Quiz: Tender Arm Lesion; Neck Stiffness and Painful Swallowing; Malignant Melanoma; Sinusitis and Myalgias?; Persistent Facial Sore
Test your clinical skills in this week’s 5-question quiz. (Source: Consultant Live)
Source: Consultant Live - April 24, 2013 Category: Primary Care Source Type: news

Correlation between respiratory cultures and sinus cultures in children with cystic fibrosis
Conclusion: In children with CF who are over eight years of age, organisms grown from sputum cultures are similar to organisms grown from sinus cultures when bacterial growth is present. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - April 22, 2013 Category: ENT & OMF Authors: Jennifer Lavin, Bharat Bhushan, James W. Schroeder Tags: Research papers Source Type: research

Histologic versus pH probe results in pediatric laryngopharyngeal reflux
Conclusion: Eighty percent of our patients (40) were either positive for reflux by pH probe or by pH probe and biopsy. The Restech Dx-pH Measurement System appeared to be well tolerated in all age groups. There were no complications. We found this a useful tool in confirming clinical suspicion of LPR. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - April 22, 2013 Category: ENT & OMF Authors: Thomas M. Andrews, Nicklas Orobello Tags: Research papers Source Type: research

Chronic sinusitis pathophysiology: The role of allergy.
CONCLUSION: Treatments of this disease include agents directed at allergic mediators such as leukotriene modifiers and corticosteroids, although this doesnot necessarily signify that an IgE-dependent mechanism can be ascribed. However, more recently, omalizumab has shown promise, including in patientswithout obvious aeroallergen sensitization. Although many aspects of the role of allergy in CHES remain a mystery, the mechanisms that are being elucidatedallow for improved understanding of this disease, which ultimately will lead to better treatments for our patients who live daily with this disease. PMID: 23601202 [PubM...
Source: American Journal of Rhinology and Allergy - April 18, 2013 Category: ENT & OMF Authors: Kennedy JL, Borish L Tags: Am J Rhinol Allergy Source Type: research

Revealing The Secrets Of Bacterial Slime
Newcastle University scientists have revealed the mechanism that causes a slime to form, making bacteria hard to shift and resistant to antibiotics. When under threat, some bacteria can shield themselves in a slimy protective layer, known as a biofilm. It is made up of communities of bacteria held together to protect themselves from attack. Biofilms cause dental plaque and sinusitis; in healthcare, biofilms can lead to life threatening and difficult to treat infections, particularly on medical implants such as catheters, heart valves, artificial hips and even breast implants... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 16, 2013 Category: Consumer Health News Tags: MRSA / Drug Resistance Source Type: news

The relationship between posterior septum deviation and depth of maxillopalatal arch
Conclusion: These findings suggest that posterior septum deviations are considered as a result of increase in maxillopalatal depth. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - April 13, 2013 Category: ENT & OMF Authors: Ercan Akbay, Yasar Cokkeser, Omer Yilmaz, Cengiz Cevik Tags: Rhinology Source Type: research

Clinical and immunological features of common variable immunodeficiency in Mexican patients.
CONCLUSION: This is the first cohort of CVID reported in Mexico We found that infection diseases were the most frequent presentations at onset. Moreover, patients had an average diagnosis delay of twelve years and thus a major prevalence of bronchiectasis. We suggest performing an extended analysis of patients with CVID patients in other Latin American countries. PMID: 23578780 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - April 8, 2013 Category: Allergy & Immunology Authors: Ramírez-Vargas N, Arablin-Oropeza SE, Mojica-Martínez D, Yamazaki-Nakashimada MA, de la Luz García-Cruz M, Terán-Juárez LM, Cortés-Grimaldo RM, Torres-Lozano C, Madrigal-Beas I, Ortega-Cisneros M, Vargas-Camaño ME, Staines-Boone T, Pietropaolo-Cien Tags: Allergol Immunopathol (Madr) Source Type: research

Subcutaneous and sublingual immunotherapy for seasonal allergic rhinitis: A systematic review and indirect comparison
Conclusions: Although there is clear evidence of effectiveness of both SCIT and SLIT, superiority of one mode of administration over the other could not be consistently demonstrated through indirect comparison, and further research is needed to establish the comparative effectiveness of SCIT versus SLIT. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 3, 2013 Category: Allergy & Immunology Authors: Janine Dretzke, Angela Meadows, Nicola Novielli, Aarnoud Huissoon, Anne Fry-Smith, Catherine Meads Tags: Rhinitis, sinusitis, and upper airway disease Source Type: research

Racial Differences in Antibiotic Prescribing by Primary Care Pediatricians
CONCLUSIONS: When treated by the same clinician, black children received fewer antibiotic prescriptions, fewer acute respiratory tract infection diagnoses, and a lower proportion of broad-spectrum antibiotic prescriptions than nonblack children. Reasons for these differences warrant further study. (Source: PEDIATRICS)
Source: PEDIATRICS - April 1, 2013 Category: Pediatrics Authors: Gerber, J. S., Prasad, P. A., Localio, A. R., Fiks, A. G., Grundmeier, R. W., Bell, L. M., Wasserman, R. C., Rubin, D. M., Keren, R., Zaoutis, T. E. Tags: Premature & Newborn Article Source Type: research

Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis
Background: Chronic rhinosinusitis (CRS) is a prevalent condition with underexplored risk factors.Objectives: We sought to determine CRS incidence and evaluate associations with a range of premorbid medical conditions for chronic rhinosinusitis without nasal polyps (CRSsNP) and chronic rhinosinusitis with nasal polyps (CRSwNP) using real-world clinical practice data.Methods: Electronic health records data from 446,480 Geisinger Clinic primary care patients were used for a retrospective longitudinal cohort study for data from 2001-2010. By using logistic regression, newly diagnosed CRS cases between 2007 and 2009 were compa...
Source: Journal of Allergy and Clinical Immunology - March 29, 2013 Category: Allergy & Immunology Authors: Bruce K. Tan, Rakesh K. Chandra, Jonathan Pollak, Atsushi Kato, David B. Conley, Anju T. Peters, Leslie C. Grammer, Pedro C. Avila, Robert C. Kern, Walter F. Stewart, Robert P. Schleimer, Brian S. Schwartz Tags: Rhinitis, sinusitis, and upper airway disease Source Type: research

Exposure To Inhaled Agents At Work Means 1 In 4 Of Operated Chronic Sinusitis Patients Fail To Recover
Exposure to occupational agents at work should be taken into account as a risk factor for the occurrence of chronic rhinosinusitis (CRS). This conclusion on the chronic sinusitis study* will be discussed, alongside other issues at the 9th Symposium on Experimental Rhinology and Immunology of the Nose, SERIN, 2013 organised by the European Academy of Allergy and Clinical Immunology, EAACI, set to take place at the University of Leuven from 21-23 March... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 22, 2013 Category: Consumer Health News Tags: Allergy Source Type: news

Effectiveness of oseltamivir in adults: a meta-analysis of published and unpublished clinical trials
Conclusions. There is no evidence that oseltamivir reduces the likelihood of hospitalization, pneumonia or the combined outcome of pneumonia, otitis media and sinusitis in the ITT population. (Source: Family Practice)
Source: Family Practice - March 21, 2013 Category: Primary Care Authors: Ebell, M. H., Call, M., Shinholser, J. Tags: Review Source Type: research

Cavernous sinus thrombosis caused by contralateral sphenoid sinusitis: a case report
Conclusions: Sphenoiditis can cause contralateral cavernous sinus thrombosis. Early surgical sphenoidotomy and aggressive medical treatment are the cornerstones of successful management of this life-threatening complication. (Source: Head and Face Medicine)
Source: Head and Face Medicine - March 13, 2013 Category: ENT & OMF Authors: Hiroaki KomatsuFumihiko MatsumotoMisato KasaiKaori KuranoDaisuke SasakiKatsuhisa Ikeda Source Type: research

Stable Bipolar Patient Switched to Mania following Clinical Doses of Prednisone.
We describe a stable bipolar female patient on medications that got switched into mania due to higher doses of prednisone prescribed for her severe sinusitis. PMID: 22937409 [PubMed] (Source: Case Reports in Psychiatry)
Source: Case Reports in Psychiatry - March 9, 2013 Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research

Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression
Background: Despite the high prevalence and morbidity of chronic rhinosinusitis (CRS), little is known about the mechanisms that underlie its pathogenesis. Recent studies have suggested that B cells might play an important role in CRS.Objective: We sought to thoroughly characterize B lineage cells within sinus tissues of patients with CRS and healthy control subjects and to determine whether levels of EBV-induced protein 2, which is known to play an important role in the development of B-cell responses, were increased in patients with CRS.Methods: Cells isolated from sinus tissues of patients with CRS and healthy control s...
Source: Journal of Allergy and Clinical Immunology - March 7, 2013 Category: Allergy & Immunology Authors: Kathryn E. Hulse, James E. Norton, Lydia Suh, Qiu Zhong, Mahboobeh Mahdavinia, Patrick Simon, Robert C. Kern, David B. Conley, Rakesh K. Chandra, Bruce K. Tan, Anju T. Peters, Leslie C. Grammer, Kathleen E. Harris, Roderick G. Carter, Atsushi Kato, Robert Tags: Rhinitis, sinusitis, and upper airway disease Source Type: research

Mayo Sinus Clinic Offers Answers to Lingering Congestion, Sinus Problems
Mayo Clinic in Florida has combined the expertise of immunologists and ear, nose, throat specialists into a Sinus Clinic which aims to treat a person's entire respiratory system, including rhinitis and sinusitis, to provide accurate answers to lingering problems. (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 1, 2013 Category: Databases & Libraries Authors: Mayo Clinic Source Type: news

Mayo Sinus Clinic Offers Answers to Lingering Congestion, Sinus Problems
Mayo Clinic in Florida has combined the expertise of immunologists and ear, nose, throat specialists into a Sinus Clinic which aims to treat a person's entire respiratory system, including rhinitis and sinusitis, to provide accurate answers to lingering problems. (Source: Mayo Clinic Jacksonville News)
Source: Mayo Clinic Jacksonville News - March 1, 2013 Category: Hospital Management Authors: Mayo Clinic Source Type: news

Comparison of Clinical Data, CT, and Bone Histopathology in Unilateral Chronic Maxillary Sinusitis.
PMID: 23562208 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 1, 2013 Category: ENT & OMF Authors: Amedee RG Tags: Am J Rhinol Allergy Source Type: research

Mini-nasoseptal flap for recalcitrant sphenoid sinusitis.
CONCLUSION: The mini-nasoseptal flap decreases the risk of restenosis after sphenoid sinusotomy by preventing circumferential cicatricial scarring and offers an effective surgical option on the spectrum of sphenoid surgical interventions in select patients. PMID: 23562205 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 1, 2013 Category: ENT & OMF Authors: Thompson CF, Deconde AS, Chiu AG, Lee JM, Suh JD Tags: Am J Rhinol Allergy Source Type: research

Trends in incidence and susceptibility among methicillin-resistant Staphylococcus aureus isolated from intranasal cultures associated with rhinosinusitis.
CONCLUSION: S. aureus and MRSA isolates from intranasal cultures, which were essentially absent before the year 2000, became significantly more common earlier this decade. These data show the increased role of MRSA in sinusitis. MRSA antibiotic susceptibilities have remained, however, largely stable during this time period. PMID: 23562203 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 1, 2013 Category: ENT & OMF Authors: Rujanavej V, Soudry E, Banaei N, Baron EJ, Hwang PH, Nayak JV Tags: Am J Rhinol Allergy Source Type: research

Sinonasal disease in polyostotic fibrous dysplasia and McCune–Albright Syndrome
ConclusionsSinonasal involvement of fibrous dysplasia in PFD/MAS is common. Symptoms are usually few and mild, and disease progression occurs primarily in young subjects. Concomitant endocrinopathy is associated with disease severity, but not progression. (Source: The Laryngoscope)
Source: The Laryngoscope - February 26, 2013 Category: ENT & OMF Authors: Timothy R. DeKlotz, Hung Jeffrey Kim, Marilyn Kelly, Michael T. Collins Tags: Rhinology Source Type: research

Intersect ENT Raises $30 Million
Funds to Fuel Commercial Expansion and Development of Next Generation Products for Chronic Sinusitis Sufferers MENLO PARK, Calif.--(Healthcare Sales & Marketing Network)--Intersect ENT, Inc., an innovator in treatment solutions for ear, nose and throat ... Devices, Venture CapitalIntersect ENT, mini sinus implants, sinusitis (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 25, 2013 Category: Pharmaceuticals Source Type: news

Marine Microbe Will Likely Benefit Sufferers Of Chronic Sinusitis
A team of scientists and surgeons from Newcastle are developing a new nasal spray from a marine microbe to help clear chronic sinusitis. They are using an enzyme isolated from a marine bacterium Bacillus licheniformis found on the surface of seaweed which the scientists at Newcastle University were originally researching for the purpose of cleaning the hulls of ships. Publishing in PLOS ONE, they describe how in many cases of chronic sinusitis the bacteria form a biofilm, a slimy protective barrier which can protect them from sprays or antibiotics... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 20, 2013 Category: Consumer Health News Tags: Ear, Nose and Throat Source Type: news

A solution to sinusitis from the sea
(Newcastle University) A team of scientists and surgeons from Newcastle are developing a new nasal spray from a marine microbe originally being investigated to clear the hulls of ships in order to help clear chronic sinusitis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 18, 2013 Category: Global & Universal Source Type: news

ACR Appropriateness Criteria Sinonasal Disease
Sinonasal imaging is performed in 2 major clinical scenarios: inflammatory rhinosinusitis or suspected mass lesion. Rhinosinusitis affects more than 16% of the US population annually. It poses an immense economic burden, accounting for more than 26 million outpatient visits annually and costing more than $4.3 billion annually in direct medical expenses. Most cases of uncomplicated acute and subacute rhinosinusitis are diagnosed clinically and should not require any imaging procedure. CT of the sinuses without contrast is the imaging method of choice in patients with recurrent acute sinusitis or chronic sinusitis. Sinusitis...
Source: Journal of the American College of Radiology : JACR - February 18, 2013 Category: Radiology Authors: Rebecca S. Cornelius, Jamie Martin, Franz J. Wippold, Ashley H. Aiken, Edgardo J. Angtuaco, Kevin L. Berger, Douglas C. Brown, Patricia C. Davis, Charles T. McConnell, Laszlo L. Mechtler, Brian Nussenbaum, Christopher J. Roth, David J. Seidenwurm Tags: Original Articles Source Type: research

Trends in Otolaryngologic Utilization of Computed Tomography for Sinonasal Disorders
ConclusionsDespite widespread availability of imaging and a strong prevalence of sinonasal diagnoses, otolaryngologists' CT ordering patterns have not resulted in increased utilization over the past 6 years. This suggests that otolaryngologists are remaining consistent in their ordering patterns for sinonasal CT. Level of Evidence2c. Laryngoscope, 2013 (Source: The Laryngoscope)
Source: The Laryngoscope - February 16, 2013 Category: ENT & OMF Authors: Neil Bhattacharyya Tags: Allergy/Rhinology Source Type: research

Patterns of Care Before and After the Adult Sinusitis Clinical Practice Guideline
ConclusionsCare patterns for the medical treatment of acute adult sinusitis have changed after guideline publication, with an increase in oral antibiotic prescription rates in cases of acute sinusitis and increase in the use of amoxicillin as the first‐line antimicrobial agent. The latter is strongly in keeping with guideline recommendation. Clinicians' espousal of the analgesic recommendations likely needs improvement to better comply with guideline recommendations. Level of Evidence2b. Laryngoscope, 2013 (Source: The Laryngoscope)
Source: The Laryngoscope - February 16, 2013 Category: ENT & OMF Authors: Neil Bhattacharyya, Lynn J. Kepnes Tags: Allergy/Rhinology Source Type: research

Comparison of Infection Risk with Alemtuzumab and SC IFNB-1a in Patients with Multiple Sclerosis Who Experienced Disease Activity While on Prior Therapy (CARE-MS II) (P01.172)
CONCLUSIONS: Although alemtuzumab increased the risk for infection compared with IFNB-1a in CARE-MS II, all infections were manageable, few were serious, and none led to study discontinuation.Supported by: Genzyme, a Sanofi company and Bayer Healthcare Pharmaceuticals.Disclosure: Dr. Wray has received personal compensation for activities with Serono, Inc., Bayer Pharmaceuticals Corporation, Genzyme Corporation, Biogen Idec, Novartis and Teva Neuroscience as a consultant, speaker and/or serving on an advisory board. Dr. Wray has received research support from Accorda, Biogen Idec, Elan, Genzyme, Novartis, Ono, Roche and Ser...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Wray, S., Arnold, D., Cohen, J., Coles, A., Confavreux, C., Fox, E., Hartung, H., Havrdova, E., Selmaj, K., Weiner, H., Miller, T., Twyman, C., Lake, S., Margolin, D., Panzara, M., Compston, A. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Phase 2 BOLD Extension Study Safety Results for Siponimod (BAF312) in Patients with Relapsing-Remitting Multiple Sclerosis (P01.176)
CONCLUSIONS: Siponimod was well tolerated during the first 12 months of extension, in line with the core trial, and no new safety signals were observed.Supported by: Novartis Pharma AG.Disclosure: Dr. Hartung has received personal compensation for activities with Biogen Idec, Teva Neuroscience, Sanofi-Aventis Pharmaceuticals, Inc., Bayer, Novartis, and Merck Serono. Dr. Selmaj has received personal compensation for activities with Biogen Idec, Genzyme, Ono Pharmaceutical, Novartis, Bayer, Hoffmann LaRoche, Merck, Serono and Synthon. Dr. Li has received personal compensation for activities with Genzyme, Novartis, and Nuron ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hartung, H.-P., Selmaj, K., Li, D., Hemmer, B., Freedman, M., Stuve, O., Rieckmann, P., Montalban, X., Ziemssen, T., Zhang-Auberson, L., Hunter, B., Rochotte, E., Wallstrom, E., Kappos, L. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Defining the Border-Zone between Episodic Migraine (EM) and Chronic Migraine (CM): Medical Comorbidities in the US Population (P03.110)
CONCLUSIONS: The comorbidity profiles of HFEM have much more in common with CM than with LFEM suggesting that HFEM and CM may bear a close biological relationship.Supported by: The American Migraine Prevalence and Prevention Study is funded through a research grant to the National Headache Foundation from Ortho-McNeil Neurologics, Inc., Titusville, NJ. Additional analyses were supported by a grant from Allergan Inc., Irvine, CA, to the National Headache Foundation. Abstract development was conducted independent of financial support.Disclosure: Dr. Serrano has received research support from Allergan, ENDO Pharmaceuticals, M...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Serrano, D., Buse, D., Reed, M., Pavlovic, J., Vollbracht, S., Sollars, C. M., Lipton, R. Tags: P03 Headache: Epidemiology Source Type: research

Outer membrane vesicles shield Moraxella catarrhalis {beta}-lactamase from neutralization by serum IgG
Conclusions Moraxella catarrhalis β-lactamase is found in, or associated with, OMVs, providing clinical relevance for the vesicles in the spread of antibiotic resistance. Furthermore, OMVs protect β-lactamase from specific IgG. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - February 7, 2013 Category: Microbiology Authors: Schaar, V., Paulsson, M., Morgelin, M., Riesbeck, K. Tags: Original research Source Type: research

Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma
Conclusion: Everolimus therapy is safe and effective for longer term (median exposure 34.2 months) treatment of patients with TSC with SEGA. Classification of evidence: This study provides Class III evidence that everolimus, titrated to trough serum levels of 5–15 ng/mL, was effective in reducing tumor size in patients with SEGA secondary to TSC for a median of 34 months. (Source: Neurology)
Source: Neurology - February 4, 2013 Category: Neurology Authors: Krueger, D. A., Care, M. M., Agricola, K., Tudor, C., Mays, M., Franz, D. N. Tags: Primary brain tumor, All Pediatric, All Epilepsy/Seizures, Other neurocutaneous disorders ARTICLE Source Type: research

Amoxicillin-Humdrum? Or Miraculous?
Busy primary care doctors, especially those who see children, prescribe it ten times a day, sometimes more. For over thirty years it's been our old steady friend, our go-to medication for bacterial ear infections, pneumonia, strep throat, and sinusitis. Evidence-based literature has its back. It's the "pink medicine," the yummy "bubble gum medicine," to which even obstinate toddlers will grudgingly capitulate.Doctors use it so often (when medically indicated, of course) that we barely even think about it. The anesthetic of the routine has been induced. But if we allow that anesthetic to be lifted, for a bit, the lifted cur...
Source: Scientific American - Official RSS Feed - February 1, 2013 Category: Science Tags: Evolution,Health,More Science Source Type: research

Stop coughing with these nine remedies - Control coughs from flu, bronchitis, asthma, pneumonia and COPD
Coughing always involves some type of irritation in the upper respiratory tract. It may be associated with a case of the flu, sinusitis, congestion, post nasal drip, or pneumonia. Additionally, coughing may be the result of chronic bronchitis, emphysema or COPD. Aside... (Source: NaturalNews.com)
Source: NaturalNews.com - February 1, 2013 Category: Consumer Health Advice Source Type: news

Rhinovirus has the unique ability to directly activate human T cells in vitro
Conclusion: Rhinovirus has the unique ability to bypass antigen presentation and directly infect and activate human T cells. This could explain the strong association of rhinovirus with exacerbation of airway diseases. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2013 Category: Allergy & Immunology Authors: Ramses Ilarraza, Yingqi Wu, Christopher D. Skappak, Farnam Ajamian, David Proud, Darryl J. Adamko Tags: Rhinitis, sinusitis, and upper airway disease Source Type: research

Intralymphatic allergen-specific immunotherapy: An effective and safe alternative treatment route for pollen-induced allergic rhinitis
Conclusions: Although this study is based on a limited number of patients, ILIT with grass-pollen or birch-pollen extracts appears to reduce nasal allergic symptoms without causing any safety problems. Hence, ILIT might constitute a less time-consuming and more cost-effective alternative to conventional subcutaneous allergen-specific immunotherapy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2013 Category: Allergy & Immunology Authors: Terese Hylander, Leith Latif, Ulla Petersson-Westin, Lars Olaf Cardell Tags: Rhinitis, sinusitis, and upper airway disease Source Type: research

Lessons from everyday practice: septic cavernous sinus thrombosis due to sphenoid sinusitis in a young patient following a road traffic accident.
PMID: 23315463 [PubMed - in process] (Source: Practical Neurology)
Source: Practical Neurology - February 1, 2013 Category: Neurology Authors: Liolios V, Petridou E, Vangelopoulos I, Puvanachandra N Tags: Pract Neurol Source Type: research

Olfactory disorders after general anesthesia
We noted with great interest your recent case report on an olfactory complication after general anesthesia . We feel that some aspects of the case history and patient's clinical presentation pose questions about whether general anesthesia was the main cause of the anosmia and hypogeusia. The patient was prone to recurrent acute sinusitis and, prior to the cholecystectomy, had acute sinusitis . (Source: Journal of Clinical Anesthesia)
Source: Journal of Clinical Anesthesia - February 1, 2013 Category: Anesthesiology Authors: Hergen Friedrich, Marco Caversaccio, Basile Nicolas Landis Tags: Correspondence Source Type: research

Reply
We thank Dr. Friedrich and colleagues for their interest in our recent case report. First, regarding the patient's history of sinusitis, we believe that the case was closely associated with general anesthesia rather than a possible case of sinusitis. The patient's loss of smell occurred after she received general anesthesia. While she had a history of sinusitis, her olfactory function was normal before the surgery and anesthesia. The chance of developing sinusitis while undergoing a cholecystectomy would be rare. The patient also reported that she had not experienced any deficits with her sense of smell, even when she expe...
Source: Journal of Clinical Anesthesia - February 1, 2013 Category: Anesthesiology Authors: Nadya M. Dhanani, Yandong Jiang Tags: Correspondence Source Type: research