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This page shows you the latest news and research items in this category.

Prevalence of pneumococcal vaccination in adult immune thrompocytopenia patients exposed to rituximab or to splenectomy
The objective of this retrolective study was to assess the prevalence of this vaccination in a cohort of ITP patients exposed to rituximab or splenectomy. © 2013 John Wiley & Sons A/S (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 27, 2013 Category: Hematology Authors: Guillaume Moulis, Laurent Sailler, Agnès Sommet, Maryse Lapeyre‐Mestre, Daniel Adoue Tags: Letter to the Editor Source Type: research

Splenectomy in older adults: indications and clinical outcomes.
Abstract The aim of this study was to improve the understanding of the indications and associated outcomes among older adults undergoing splenectomy. Data regarding patients of age ≥60 years treated between 1998 and 2008 were reviewed. Fifty patients (age 71.6 ± 8) were identified. Common indications for splenectomy included idiopathic thrombotic purpura (26.0 %) and lymphoma (28.0 %). Patient co-morbidities included hypertension (54 %), coronary artery disease (24 %) and diabetes mellitus (20 %). Twenty-seven patients (54 %) underwent laparoscopic surgery; 23 (46 %) had open procedures; more than half...
Source: International Journal of Hematology - February 27, 2013 Category: Hematology Authors: Frasier LL, Malani PN, Diehl KM Tags: Int J Hematol Source Type: research

Indications for and efficacy of splenectomy for haematological disorders
ConclusionSplenectomy is an effective procedure in the diagnosis and treatment of haematological disease in selected patients. (Source: British Journal of Surgery)
Source: British Journal of Surgery - February 21, 2013 Category: Surgery Authors: K. A. Bickenbach, M. Gonen, D. M. Labow, V. Strong, M. L. Heaney, A. D. Zelenetz, D. G. Coit Tags: Original Article Source Type: research

Associating portal congestive gastropathy and hepatic fibrosis in hepatosplenic mansoni schistosomiasis.
This study aimed to investigate the association between PCG with parameters of portal hypertension and the intensity of periportal fibrosis assessed by ultrasonography, in patients with mansoni schistosomiasis. A prospective study was made of 71 patients whether or not they had a history of upper digestive bleeding, and who had not been previously treated for portal hypertension (splenectomy, use of beta blockers or endoscopic treatment). Patients with other liver diseases were excluded. After signing a form of consent, the patients underwent endoscopy, as well as ultrasonography of the abdomen, and hematological, biochemi...
Source: Acta Tropica - February 19, 2013 Category: Infectious Diseases Authors: Soares Dias H, Coutinho Domingues AL, Miranda Cordeiro FT, Jucá N, Lopes EP Tags: Acta Trop Source Type: research

Splenectomy Protect Experimental Rats from Cerebral Damage after Stroke by Anti-Inflammation (P02.035)
CONCLUSIONS: Mechanism that splenectomy protect brain from damages induced by stroke may correlate with the decreased concentration of inflammatory cells in the ischemic zone of brain and changes in inflammatory cytokines in the central nervous system and blood.Disclosure: Dr. Zhang has nothing to disclose. Dr. Men has nothing to disclose. Dr. Lu has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Zhang, B., Men, X., Lu, Z. Tags: P02 Cerebrovascular Disease II Source Type: research

Thrombolysis of Portal Vein Thrombosis After Splenectomy Post Liver Transplant
(Source: Liver Transplantation)
Source: Liver Transplantation - February 13, 2013 Category: Transplant Surgery Authors: Dean Y. Kim, Lloyd Brown, Ahmad Abou Abbass, Shunji Nagai, Vrishali Patil, Marwan Abouljoud, Todd Getzen, Atsushi Yoshida, Marwan Kazimi Tags: Letter from the Frontline Source Type: research

Immunoenhancing therapy with interleukin-18 against bacterial infection in immunocompromised hosts after severe surgical stress.
Abstract IL-18 has a potential to up-regulate the Th1 and Th2 immune responses. It is known that IL-18, in synergy with IL-12, augments the Th1 response to bacterial infections, but it also augments the Th2 response to allergic disorders in the absence of IL-12. Although the Th1 and Th2 immune responses cross-regulate each other, our recent murine studies have demonstrated that multiple, alternate-day IL-18 injections (but not a single injection) could augment not only the Th1 immune response but also the Th2 immune response, including IgM production against bacterial infection in mice. In addition, critically ill ...
Source: Journal of Leukocyte Biology - February 13, 2013 Category: Hematology Authors: Kinoshita M, Miyazaki H, Ono S, Seki S Tags: J Leukoc Biol Source Type: research

Towards Personalized Medicine in Sepsis: Quest for Shangri-La?
Background: Severe sepsis is typically characterized by initial cytokine-mediated hyper- inflammation. Whether this hyper-inflammatory phase is followed by immunosuppression is controversial. Animal studies suggest that multiple immune defects occur in sepsis, but data from humans remain conflicting.ObjectiveTo determine the association of sepsis with changes in host innate and adaptive immunity and to examine potential mechanisms for putative immunosuppressionDesignRapid prospective postmortem spleen and lung tissue harvest and analysis within 120 minutes of deathSetting- Intensive care units (ICUs) of academic medical ce...
Source: Critical Care - February 10, 2013 Category: Intensive Care Authors: Ayan SenSachin Yende Source Type: research

Radnor Veterinary Hospital Discusses Pet Surgery Services
WAYNE, Pa., Feb. 10, 2013 (GLOBE NEWSWIRE) -- Radnor Veterinary Hospital offers preventive pet surgery like spays, neuters, dental cleanings, as well as more advanced procedures such as soft tissue surgery, endoscopy, and orthopedic surgery. The veterinary hospital's advanced surgical capabilities include splenectomy, gastrointestinal surgery (foreign body retrieval/anastamosis/gall bladder removal), cystotomy, endoscopy and many other types of exploratory surgery. Pre-operative diagnostics are used to prepare patients for the best outcome possible. This may include blood testing, EKG, digital radiography (x-ray), or even ...
Source: Medical News (via PRIMEZONE) - February 10, 2013 Category: Pharmaceuticals Source Type: news

Transient Elastography in HCV‐Infected patients with Beta‐Thalassemia for Assessment of Fibrosis
ConclusionRegardless of LIC, TE alone or when combined with FIB‐4 or APRI, is a diagnostic tool with moderate to high accuracy to evaluate liver fibrosis in CHC patients with beta‐thalassemia. However, since splenectomy in a proportion of our subjects might affect the platelet count, the scores utilizing APRI and FIB‐4 should be interpreted cautiously. (Source: Hepatology Research)
Source: Hepatology Research - February 7, 2013 Category: Internal Medicine Authors: Hossein Poustchi, Masoomeh Eslami, Mohammad Reza Ostovaneh, Amirhossein Modabbernia, Fatemeh Sima Saeedian, Shervin Taslimi, Jacob George, Reza Malekzadeh, Farhad Zamani Tags: Original Article Source Type: research

Iatrogenic splenectomy during nephrectomy for renal tumors
ConclusionsIatrogenic splenectomy is a rare complication during nephrectomy and is associated with locally advanced tumors (≥pT3). It also carries prognostic significance for adverse perioperative outcomes and possibly diminished survival, although this warrants further study. (Source: International Journal of Urology)
Source: International Journal of Urology - February 4, 2013 Category: Urology & Nephrology Authors: Jeffrey K Wang, Matthew K Tollefson, Simon P Kim, Stephen A Boorjian, Bradley C Leibovich, Christine M Lohse, John C Cheville, R Houston Thompson Tags: Original Article Source Type: research

The effects of splenectomy on lipid peroxidation and neuronal loss in experimental spinal cord ischemia/reperfusion injury.
CONCLUSION: SCIR injury affects lipid peroxidation in rats. Prior splenectomy does not attenuate lipid peroxidation, but prevents neuronal loss after SCIR injury. PMID: 23344870 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - January 29, 2013 Category: Neurosurgery Authors: Temiz C, Solmaz I, Tehli O, Kaya S, Onguru O, Arslan E, Izci Y Tags: Turk Neurosurg Source Type: research

Primary myelofibrosis: 2013 update on diagnosis, risk‐stratification, and management
Disease overviewPrimary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by stem cell‐derived clonal myeloproliferation, abnormal cytokine expression, bone marrow fibrosis, anemia, splenomegaly, extramedullary hematopoiesis (EMH), constitutional symptoms, cachexia, leukemic progression, and shortened survival. DiagnosisDiagnosis is based on bone marrow morphology. The presence of fibrosis, JAK2/MPL mutation, or +9/13q− cytogenetic abnormality is supportive but not essential for diagnosis. Prefibrotic PMF mimics essential thrombocythemia in its presentation and the distinction is prognostically relevan...
Source: American Journal of Hematology - January 24, 2013 Category: Hematology Authors: Ayalew Tefferi Tags: A Continuing Medical Education Series Source Type: research

Starting the clock: defining nonoperative management of blunt splenic injury by time
Conclusions: The grade of injury is an important predictor for failure of NOM. If a 5% failure rate is to be considered a benchmark, then the 5-hour time point after admission should be used for the calculation of NOM success rates. (Source: American Journal of Surgery)
Source: American Journal of Surgery - January 24, 2013 Category: Surgery Authors: Elan Jeremitsky, R. Stephen Smith, Adrian W. Ong Tags: Presidential Address Source Type: research

Treatment of Splenic Marginal Zone Lymphoma With Rituximab Monotherapy: Progress Report and Comparison With Splenectomy.
Conclusions. Rituximab is a very effective and well-tolerated therapy and may be substituted for splenectomy as the first-line treatment of choice for patients with SMZL. PMID: 23345547 [PubMed - as supplied by publisher] (Source: The Oncologist)
Source: The Oncologist - January 23, 2013 Category: Cancer & Oncology Authors: Kalpadakis C, Pangalis GA, Angelopoulou MK, Sachanas S, Kontopidou FN, Yiakoumis X, Kokoris SI, Dimitriadou EM, Dimopoulou MN, Moschogiannis M, Korkolopoulou P, Kyrtsonis MC, Siakantaris MP, Papadaki T, Tsaftaridis P, Plata E, Papadaki HE, Vassilakopoulos Tags: Oncologist Source Type: research

[Recurrent somatic mutation in hairy cell leukemia].
This article reviews the significance of this observation and presents the different types of methods for the detection of this mutation. Orv. Hetil., 2013, 154, 123-127. PMID: 23335721 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - January 22, 2013 Category: Journals (General) Authors: Sári E, Nagy Z, Demeter J Tags: Orv Hetil Source Type: research

An Uncommon Cause of a Focal Liver Lesion
Question: A 62-year-old man with a chronic hepatitis C and liver cirrhosis Child A was referred for abdominal computed tomography (CT) after a nodular liver lesion in segment V was found on ultrasonography. His medical history included esophageal varices grade I, reflux esophagitis grade III, and a posttraumatic splenectomy 50 years ago. The physical examination was unremarkable and the laboratory values were normal (alpha-fetoprotein, 1.9 µg/L). Abdominal CT scan revealed a homogenous, smoothly outlined, round lesion measuring 15 × 18 mm located between the gallbladder and the liver (segment V). During the arterial phas...
Source: Gastroenterology - January 21, 2013 Category: Gastroenterology Authors: Mareike Röther, Jean-Francois Dufour, Beat Schnüriger Tags: Clinical Challenges and Images in GI Source Type: research

Incidence, Risk Factors, and Outcome of Portal Vein Thrombosis After Laparoscopic-Assisted Splenectomy in β-Thalassemia Patients: A Prospective Exploratory Study
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - January 18, 2013 Category: Surgery Tags: article Source Type: research

Single-Incision Pediatric Endosurgery (SIPES) Splenectomy: A Case-Control Series
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - January 17, 2013 Category: Surgery Tags: article Source Type: research

Multidetector CT Anatomy of Drainage Routes of Gastric Varices: A Pictorial Review [Gastrointestinal Imaging]
Most gastric varices arise at hepatofugal collateral pathways and drain into the systemic vein through one or both of two different types of portosystemic collateral drainage systems: the gastroesophageal (azygous) venous system and the gastrophrenic venous system. The gastroesophageal venous system consists of gastric varices contiguous with esophageal varices, paraesophageal varices, and the azygos vein, which terminates into the superior vena cava. Gastric varices draining through the gastroesophageal venous system can be treated with endoscopic techniques or creation of a transjugular intrahepatic portosystemic shunt. ...
Source: Radiographics recent issues - January 15, 2013 Category: Radiology Authors: Kiyosue, H., Ibukuro, K., Maruno, M., Tanoue, S., Hongo, N., Mori, H. Tags: Interventional Radiology, Vascular Imaging, Computed Tomography, Gastrointestinal Radiology Gastrointestinal Imaging Source Type: research

Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus‐related cirrhotic patients
ConclusionProthrombin time and total bilirubin improve in approximately half of cirrhotic patients within a year after splenectomy. HVWF type I and splenomegaly may be predictive factors for improvement in prothrombin time after splenectomy in patients with cirrhosis due to hepatitis C. (Source: Hepatology Research)
Source: Hepatology Research - January 14, 2013 Category: Internal Medicine Authors: Nao Kinjo, Yoshihiro Nagao, Tomohiko Akahoshi, Kamori Masahiro, Naotaka Hashimoto, Hideo Uehara, Hirohumi Kawanaka, Morimasa Tomikawa, Ken Shirabe, Makoto Hashizume, Yoshihiko Maehara Tags: Original Article Source Type: research

Strategies for Successful Left-Lobe Living Donor Liver Transplantation in 250 Consecutive Adult Cases in a Single Center
Conclusions: The outcomes of left-lobe LDLT were improved by accumulated experience and technical developments. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - January 14, 2013 Category: Surgery Authors: Toru Ikegami, Ken Shirabe, Yuji Soejima, Tomoharu Yoshizumi, Hideaki Uchiyama, Yo-ichi Yamashita, Norifumi Harimoto, Takeo Toshima, Shohei Yoshiya, Tetsuo Ikeda, Yoshihiko Maehara Tags: Original Scientific Articles Source Type: research

Outcomes Following Splenectomy in Patients With Myeloid Neoplasms
(Source: Journal of Surgical Research)
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: K.L. Rialon, S. Thomas, E.P. Ceppa, S.N. Vaslef, D.S. Tyler, D.G. Blazer Tags: Quickshot Session: Thursday 2/7 3:30 PM to 5:30 PM Source Type: research

Splenectomy Correlates With Worse Survival Independent of Disease Burden After Cytoreduction and Heated Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma
Malignant peritoneal mesothelioma (MPM) is commonly treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). We evaluated the impact of splenectomy on postoperative outcomes in patients with MPM. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: N.P. Schaub, M. Alimchandani, M. Quezado, S.M. Steinberg, R. Langan, M.M. Hughes, T. Beresnev, D.L. Bartlett, S.K. Libutti, J.F. Pingpank, R.E. Royal, B. Brcher, P. Pandalai, G.Q. Phan, A. Stojadinovich, U. Rudloff, H.R. Alexander, I. Avital Tags: Oral Session: Thursday 2/7 7:30 AM to 9:30 AM Source Type: research

Surgery as primary prophylaxis from variceal bleeding in patients with extrahepatic portal venous obstruction
ConclusionIn patients with EHO, prophylactic surgery is fairly safe and prevents variceal bleeding in ∼ 94% of patients with no occurrence of portosystemic encephalopathy. Patients with EHO who have not bled but have high‐risk varices and/or hypersplenism and poor access to medical facilities should be offered prophylactic operations. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - January 10, 2013 Category: Gastroenterology Authors: Sujoy Pal, Vivek Mangla, Patta Radhakrishna, Peush Sahni, Girish Kumar Pande, Subrat Kumar Acharya, Tushar Kanti Chattopadhyay, Samiran Nundy Tags: Clinical Hepatology Source Type: research

Spleen endothelial cells from patients with myelofibrosis harbor the JAK2V617F mutation
In conclusion, we provide evidence that some ECs from the spleen and splenic veins of patients with MF bear the JAK2V617F mutation. We suggest that splenic ECs are involved in the process of malignant transformation in MF. (Source: Blood)
Source: Blood - January 10, 2013 Category: Hematology Authors: Rosti, V., Villani, L., Riboni, R., Poletto, V., Bonetti, E., Tozzi, L., Bergamaschi, G., Catarsi, P., Dallera, E., Novara, F., Massa, M., Campanelli, R., Fois, G., Peruzzi, B., Lucioni, M., Guglielmelli, P., Pancrazzi, A., Fiandrino, G., Zuffardi, O., Ma Tags: Myeloid Neoplasia Source Type: research

Immunoarchitectural patterns in splenic marginal zone lymphoma: correlations with chromosomal aberrations, ighv mutations, and survival. A study of 76 cases
ConclusionWe report the histological spectrum of SMZL and discuss the differential diagnosis and requirement of molecular and cytogenetic characteristics in atypical cases.© 2013 Blackwell Publishing Ltd (Source: Histopathology)
Source: Histopathology - January 10, 2013 Category: Pathology Authors: A Traverse‐Glehen, E Bachy, L Baseggio, E Callet‐Bauchu, S Gazzo, A Verney, S Hayette, L Jallades, M Ffrench, G Salles, B Coiffier, P Felman, F Berger Tags: Original Article Source Type: research

Spleen injuries in Spain: At what point are we?
CONCLUSION: In Spain, management of spleen trauma is mainly surgical (particularly splenectomy). Angio-embolization and conservative surgical procedures are now hardly used. PMID: 23312699 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - January 8, 2013 Category: Surgery Authors: Jiménez Fuertes M, Costa Navarro D, Jover Navalón JM, Turégano Fuentes F, Ceballos Esparragón J, Yuste P, Sánchez Tocino JM, Navarro Soto S, Montmany S Tags: Cir Esp Source Type: research

Strategic breakthrough in adult ABO‐incompatible living donor liver transplantation: preliminary results of consecutive seven cases
In conclusion, adult ABO‐I LDLT results were excellent – comparable or even superior to those of ABO‐compatible LDLT. ABO‐I adult LDLT has now become a more applicable modality without the need for an appropriate donor. (Source: Clinical Transplantation)
Source: Clinical Transplantation - January 7, 2013 Category: Transplant Surgery Authors: Yuji Soejima, Jyun Muto, Rumi Matono, Mizuki Ninomiya, Tetsuo Ikeda, Tomoharu Yoshizumi, Hideaki Uchiyama, Toru Ikegami, Ken Shirabe, Yoshihiko Maehara Tags: Original Article Source Type: research

Editor's quiz: Protein, protein everywhere...but none to keep
A 72-year-old woman presented to the outpatient department with a 3-month history of non-bloody diarrhoea and weight loss. Her past medical history was notable for non-Hodgkin's lymphoma (splenectomy performed 10 years prior; no evidence of recurrence on follow-up) and cardiac pacemaker insertion. Physical examination demonstrated significant proximal muscle wasting and peripheral oedema. Laboratory findings at presentation showed an albumin of 28 g/l but tissue-transglutaminase antibody was absent, and stool tested negative for common and opportunistic pathogens, parasitic infections and toxins. Faecal α-1...
Source: Gut - January 4, 2013 Category: Gastroenterology Authors: Pavlides, M., Trivedi, P., Gill, P., Appleton, S., Cullen, S., McIntyre, A. Tags: GUT Snapshot Editor ' s quiz: GI snapshot Source Type: research

Splenic sarcoidosis mimicking neoplastic disease
Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause that commonly involves the spleen. Sarcoid can produce either homogeneous splenomegaly or multiple splenic nodules. Although other organ system involvement usually occurs, this is not invariable. Herein, we report on the clinical, histological, and radiological features—including sonography and MRI—of an isolated splenic sarcoidosis that mimicked neoplastic disease in a 37‐year‐old female. Knowledge of this atypical sonographic presentation may prevent unnecessary splenectomy. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 2013 (Source...
Source: Journal of Clinical Ultrasound - January 1, 2013 Category: Radiology Authors: Salem Bauones, Thomas Le Corroller, Olivier Durieux, Daphné Guenoun, Jean Del Grande, Nicolas Pirro, Pierre Champsaur Tags: Case Report Source Type: research

[Splenic cyst during pregnancy: A rare disease with difficult management.]
Abstract Maternal splenic cyst during pregnancy seems to be a rare disease whose treatment is not codified. The most feared complication of these cysts is the rupture. In case of rupture, 60% of cases occur during the third trimester of pregnancy and result in a significant maternal and fetal morbidity and mortality. We examine the two main modes of treatment used nowadays: surgical splenectomy or radiological drainage. PMID: 23265673 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)
Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction - December 19, 2012 Category: OBGYN Authors: Hamm JA, Deloménie M, Derniaux E, Durier M, Loock M, Abboud P, Graesslin O Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: research

Outcome of Laparoscopic Splenectomy with Sandwich Treatment Including Pericardial Devascularization and Limited Portacaval Shunt for Portal Hypertension Due to Liver Cirrhosis
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - December 18, 2012 Category: Surgery Tags: article Source Type: research

NICE issues Appraisal Consultation Document on eltrombopag for thrombocytopenic purpura (review of TA205)
Source: NICE Area: News Following a review of the previously issued Technology Appraisal guidance (TA205) on eltrombopag for thrombocytopenic purpura, the National Institute for Health and Clinical Excellence (NICE) has issued an Appraisal Consultation Document making the following preliminary recommendations: . Eltrombopag is recommended within its marketing authorisation as an option for treating chronic immune (idiopathic) thrombocytopenia purpura in adults who have had a splenectomy and whose condition is refractory to other treatments (for example, corticosteroids or immunoglobulins) or as second-line...
Source: NeLM - News - December 18, 2012 Category: Drugs & Pharmacology Source Type: news

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells
Primary immune thrombocytopenia (ITP) is a disorder caused by autoantibody-mediated platelet destruction and decreased platelet production. Rituximab, a B cell–depleting agent, has become the first-line treatment for ITP; however, patients with refractory disease usually require splenectomy. We identified antibody-secreting cells as the major splenic B cell population that is resistant to rituximab. The phenotype, antibody specificity, and gene expression profile of these cells were characterized and compared to those of antibody-secreting cells from untreated ITP spleens and from healthy tissues. Antiplatelet-spec...
Source: Journal of Clinical Investigation - December 17, 2012 Category: Biomedical Science Authors: Matthieu Mahévas, Pauline Patin, François Huetz, Marc Descatoire, Nicolas Cagnard, Christine Bole-Feysot, Simon Le Gallou, Mehdi Khellaf, Olivier Fain, David Boutboul, Lionel Galicier, Mikael Ebbo, Olivier Lambotte, Mohamed Hamidou, Philippe Source Type: research

Increased circulating red cell microparticles (RMP) and platelet microparticles (PMP) in immune thrombocytopenic purpura
In conclusion: Chronic ITP was associated with increased levels of RMP and PMP. FVIII, FIX and FXI were increased in ITP patients but showed a negative correlation with platelet count. Splenectomy was associated with increased levels of RMP and lower levels of FIX and F XI. The high level of microparticles in ITP might point towards a prothrombotic tendency. (Source: Thrombosis Research)
Source: Thrombosis Research - December 17, 2012 Category: Hematology Authors: Eman M. Sewify, Douaa Sayed, Refat F. Abdel AAl, Heba M. Ahmad, Madleen A. Abdou Tags: Platelets and cell biology Source Type: research

CLIN] - Splenectomy for massive splenomegaly offers effective palliation in hematologic disorders
NEW YORK (Reuters Health) - Splenectomy for massive splenomegaly reduces pressure-related symptoms in nearly all patients with hematologic disorders, according to a review of 222 consecutive cases. (Source: Modern Medicine)
Source: Modern Medicine - December 14, 2012 Category: Journals (General) Source Type: news

A unique case of peripheral myoclonus
Introduction Myoclonus is a sudden, brief, involuntary muscle jerk, sufficient to cause movement. Cortical myoclonus is well recognised and characterises many neurological diseases1 Myoclonus can be classified by presumed cause or anatomical origin. Peripherally generated myoclonus is not well characterised, with the exception of hemifacial spasm (HFS). Case report A 71-year-old woman awoke with a twitching of her right hand, which persisted despite distraction, sleep or voluntary use of the hand. The ‘twitch’ comprised a single complex movement, involving contraction of abductor digiti minimi (ADM) and flexor ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 13, 2012 Category: Neurosurgery Authors: Ross Russell, A. L., Knight, W., Oware, A., Fuller, G. N. Tags: PostScript Source Type: research

Use of the remnant stomach for oesophagoplasty in patients following distal gastrectomy [REVIEWS]
Oesophageal replacement in patients following distal gastrectomy (DGE) remains a surgical challenge, and the standard option is the colonic or jejunal transplant. However, in some cases, it is possible (or mandatory) to utilize the remnant stomach for oesophagoplasty (EP). This method preserves some advantages of the gastric EP in comparison with the bowel EP. During recent years, several papers have been published in English regarding remnant stomach EP, and different aspects of this procedure have been discussed. However, there is still no comprehensive literature review analysing the possible EP approaches using the rem...
Source: European Journal of Cardio-Thoracic Surgery - December 12, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Shiryajev, Y. N. Tags: REVIEWS Source Type: research

Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in HCV‐related cirrhotic patients.
ConclusionsProthrombin time and total bilirubin improve in about half of cirrhotic patients within a year after splenectomy. HVWF type I and splenomegaly might be predictive factors for improvement in prothrombin time after splenectomy in patients with cirrhosis due to hepatitis C. (Source: Hepatology Research)
Source: Hepatology Research - December 12, 2012 Category: Internal Medicine Authors: N. Kinjo, Y. Nagao, T. Akahoshi, M. Kamori, N. Hashimoto, H. Uehara, H. Kawanaka, M. Tomikawa, K. Shirabe, M. Hashizume, Y. Maehara Tags: Original Article Source Type: research

Long-Term Results After Splenectomy in Adult Idiopathic Thrombocytopenic Purpura: Comparison Between Open and Laparoscopic Procedures
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - December 11, 2012 Category: Surgery Tags: article Source Type: research

Laparoscopic Repair of Epiphrenic Diverticulum
Epiphrenic diverticulum of the esophagus is an uncommon disease, and its pathogenesis remains unclear. Surgical repair of this disease is warranted only for symptomatic patients because treatment carries high risk of morbidity. Over the past decade, the laparoscopic approach to epiphrenic diverticulectomy has been shown to be safe and effective. The aim of the study was to describe our specific approach to the procedure and results. From 1994 to 2012, 30 patients with symptomatic epiphrenic diverticulum underwent laparoscopic surgery. There were no conversions to open surgery. The postoperative course was uneventful in 28 ...
Source: Seminars in Thoracic and Cardiovascular Surgery - December 11, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Uberto Fumagalli Romario, Martina Ceolin, Matteo Porta, Riccardo Rosati Tags: Techniques My Way Source Type: research

Surgical Trauma Induces Iron Accumulation and Oxidative Stress in a Rodent Model of Postoperative Cognitive Dysfunction.
In this study, we investigated the role of iron accumulation within the central nervous system in the development of cognitive dysfunction in rats following splenectomy. Cognitive function was assessed using a Morris water maze on postoperative days 1, 3, and 7. Impaired cognitive function was observed on days 1 and 3 after splenectomy, while an anesthesia-alone group showed no significant difference from the control. Serum iron levels decreased and brain iron content increased on days 1 and 3 after surgery, which was in parallel with the impairment of cognitive function. Furthermore, the levels of proteins involved in the...
Source: Biological Trace Element Research - December 11, 2012 Category: Biology Authors: An LN, Yue Y, Guo WZ, Miao YL, Mi WD, Zhang H, Lei ZL, Han SJ, Dong L Tags: Biol Trace Elem Res Source Type: research

Transumbilical Single-Incision Laparoscopic Splenectomy Plus Pericardial Devascularization Using Conventional Instruments: Initial Experience of 5 Cases
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - December 10, 2012 Category: Surgery Tags: article Source Type: research

Effects of spleen status on early outcomes after hematopoietic cell transplantation
K Ballen, K R Cooke, P L McCarthy & V T Ho (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 10, 2012 Category: Hematology Authors: G AkpekM C PasquiniB LoganM-A AgoviH M LazarusD I MarksM BornhaeüserO RingdénR T MaziarzV GuptaU PopatD MaharajB J BolwellJ D RizzoK K BallenK R CookeP L McCarthyV T Ho Tags: engraftment splenectomy spleen SCT myeloproliferative disease Source Type: research

What Causes Thrombocytosis?
Discussion Cytomegalovirus (CMV) belongs to the herpes virus family. It can be acquired though contact with infected body fluids and cause primary infection. It can also become latent and then reactivated. It is also possible to become infected with another CMV strain. Primary maternal CMV infection has a 30-40% risk of transplacental transmission to the fetus, and if infected a 20-25% risk of some type of developmental problems in the child. Most congenitally infected infants have no symptoms at birth but 5-15% will have sequelae such as hearing loss, vision problems or mental retardation. If affected at birth, common sy...
Source: PediatricEducation.org - December 9, 2012 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Neuroendocrine carcinoma of the pancreas with soft tissue metastasis.
We report the case of a 34-year-old man with pancreatic NEC with soft tissue metastasis. The patient presented with right upper abdominal discomfort. Computed tomography revealed a low-density heterogeneous mass in the tail and body of the pancreas that encroached on the greater curvature of the stomach and spleen. We performed exploratory laparotomy and total pancreatectomy with splenectomy and total gastrectomy. Histopathological analysis showed spindle-shaped cells with scanty cytoplasm and hyperchromatic nuclei, confirming a primary pancreatic NEC. One month after the surgery, the patient experienced leg swelling. Posi...
Source: World Journal of Gastroenterology : WJG - December 7, 2012 Category: Gastroenterology Authors: Chen J, Zheng Q, Yang Z, Huang XY, Yuan Z, Tang J Tags: World J Gastroenterol Source Type: research

Primary Versus Secondary Splenic Pedicle Dissection in Laparoscopic Splenectomy for Splenic Diseases
Conclusions: Secondary splenic pedicle dissection can decrease the incidence of splenic fever and pancreatic leakage and is a valuable technique for LS for normal-sized spleen or moderate splenomegaly. It is not a safe procedure for massive splenomegaly because of the high conversion rate. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - December 3, 2012 Category: Surgery Authors: Qiuliang Yan, Jinhui Zhu, Xiaoli Zhan, Weihong Weng, Wanbo Wu, Dijian Shen, Kai Yu, Yuedong Wang Tags: Original Scientific Articles Source Type: research

Spleen‐preserving distal pancreatectomy with and without splenic vessel ligation: a systematic review
DiscussionWT is technically easier to perform than SVP but has a higher incidence of subsequent splenectomies. Surgeons should be able to perform both procedures and tailor the technique according to the patient. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - December 2, 2012 Category: Gastroenterology Authors: Gaurav Jain, Saurav Chakravartty, Ameet G. Patel Tags: Review Article Source Type: research

Spleno-adrenal shunt: A novel alternative for portosystemic decompression in children with portal vein cavernous transformation
We describe our 10year experience focusing on technique evolution and treatment efficacy.Methods: Between 2001 and 2011, 15 children (9 girls and 6 boys, ages 3–11years, median: 6years) with PVCT, portal hypertension, and hypersplenism were treated with SA shunt with splenectomy in Shanghai Children's Medical Center. All children in the study had endoscopy proven active esophageal variceal bleeding requiring multiple transfusions (mean: 4.2 units) with failed sclerotherapy (mean: 2.6 times). Greater omental vein pressure (GVP) approximating portal venous pressure was measured pre- and post-SA shunt. Pre- and post-operati...
Source: Journal of Pediatric Surgery - December 1, 2012 Category: Surgery Authors: Song Gu, Shirong Chang, Jun Chu, Min Xu, Zhilong Yan, Donald C. Liu, Qimin Chen Tags: PAPS Papers Source Type: research