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25379 records returned
Decoupling two-step anodization in anodic aluminum oxide
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Kwang Hong Lee and C. C. Wong It is well known that ordered anodic aluminum oxide (AAO) can be fabricated by a two-step anodization process, but in the current approach, pore size and interpore spacing are coupled because the ordering mechanism is expected to be the same in both steps. Here, we demonstrate that, by using a diffe ... [J. Appl. Phys. 106, 104305 (2009)] published Thu Nov 19, 2009.
Source: Journal of Applied Physics - November 20, 2009 Category: Physics Source Type: journals
Portable power supply takes a step forwardEmail this article to a colleague.
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Chinese scientists have developed membranes that could improve direct methanol fuel cells
Source: Chemistry World | Latest News - November 20, 2009 Category: Chemistry Source Type: journals
Maternal Mortality Halved in Eastern Europe and Central Asia, but Too Many Women Still Die Giving Life - 12 November 2009Email this article to a colleague.
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ISTANBUL – Decision-makers and government officials from 20 countries in Eastern Europe and Central Asia have pledged to step up the fight against needless deaths and suffering resulting from pregnancy and childbirth. In a Statement of Commitment issued in Istanbul late last night, delegates to a high-level meeting recognized that investment in the health and rights of women is smart economics, especially during a financial crisis, and that family planning is one of the most cost-effective investments in reducing the maternal deaths that continue to affect the region.
Source: UNFPA News - November 20, 2009 Category: Global & Universal Source Type: organizations
Feasibility of foot and ankle strength training in childhood Charcot-Marie-Tooth diseaseEmail this article to a colleague.
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Abstract: Weakness of ankle dorsiflexion is the cardinal manifestation of CMT. We investigated if a 12-week progressive resistance dorsiflexion strengthening program was feasible, safe and beneficial in a 15-year-old girl with an axonal form of CMT. Training load was based on a dose-escalating percentage of one-repetition maximum, completed on three non-consecutive days each week. Outcomes included dynamometric foot strength, motor function and instrumented walking ability. At 12-weeks, dorsiflexion strength improved 56–72% and plantarflexion strength by 15–20%. Standing long jump increased by 16%, while balance and en...
Source: Neuromuscular Disorders - November 20, 2009 Category: Neurology Authors: Joshua Burns, Jacqueline Raymond, Robert Ouvrier Tags: Research papers Source Type: journals
Newborn hearing screening on infants at riskEmail this article to a colleague.
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Conclusion: Our selected hearing screening on infants at risk allowed 60 deaf children access to early management. However, too many children were lost to follow up; which revealed that better information regarding risk of hearing loss must be provided to parents and paramedics and universal newborn screening needs to be performed. The most important result of this study is that in a population of hearing impaired children, with an impairment incidence close to what is commonly reported, the association of several risk factors proves to be a significant additional risk factor for hearing impairment.
Source: International Journal of Pediatric Otorhinolaryngology - November 20, 2009 Category: ENT & OMF Authors: Christine Ohl, Liliane Dornier, Cécile Czajka, Jean-Claude Chobaut, Laurent Tavernier Tags: Research papers Source Type: journals
A new weapon against allergies and asthmaEmail this article to a colleague.
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Researchers at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks. Their advance is a significant step toward crafting pharmaceuticals to fight these often life-endangering conditions in a new way........
Source: Medicineworld.org: New Article Alert - November 20, 2009 Category: Consumer Health News Source Type: info
Potential Strategy To Help Generate HIV-Neutralizing AntibodiesEmail this article to a colleague.
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WHAT: New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: HIV / AIDS Source Type: news
Leeds research finds new piece of BSE puzzleEmail this article to a colleague.
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New research funded mainly through the Wellcome Trust with additional support from the Medical Research Council shows that a new treatment route for BSE and its human form CJD could be a step closer.
Source: Medical Research Council Press Releases - November 20, 2009 Category: Consumer Health News Source Type: organizations
Statement By Medicare Rights Center President Joe Baker On The House Vote To Repeal Medicare Pay Cuts For DoctorsEmail this article to a colleague.
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Today's vote by the House of Representatives is an important step toward repealing the 21.5 percent Medicare pay cut for doctors set to take effect next year, and moves to stabilize Medicare's payment system for doctors for the long term. People with Medicare must be able to maintain relationships with the doctors they trust.
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Medicare / Medicaid / SCHIP Source Type: news
White House Backing Medicare 'Doc Fix' BillEmail this article to a colleague.
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Reuters reports that the White House Wednesday "urged Congress to pass a bill to boost Medicare payments to doctors, a step that could shore up support" from the American Medical Association for health care reform. The bill, which would stop a scheduled 21 percent cut in doctor Medicare payments next year and implement a fee schedule that pays doctors more, has been endorsed by the AMA.
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Medicare / Medicaid / SCHIP Source Type: news
Saliva Proteins Change As Women AgeEmail this article to a colleague.
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In a step toward using human saliva to tell whether those stiff joints, memory lapses, and other telltale signs of aging are normal or red flags for disease, scientists are describing how the protein content of women's saliva change with advancing age.
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Women's Health / Gynecology Source Type: news
Saliva Proteins Change As Women AgeEmail this article to a colleague.
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In a step toward using human saliva to tell whether those stiff joints, memory lapses, and other telltale signs of aging are normal or red flags for disease, scientists are describing how the protein content of women's saliva change with advancing age. The discovery could lead to a simple, noninvasive test for better diagnosing and treating certain age-related diseases in women, they suggest in a report in ACS' Journal of Proteome Research, a monthly publication.
Source: Seniors / Aging News From Medical News Today - November 20, 2009 Category: Geriatrics Tags: Women's Health / Gynecology Source Type: news
Evaluation of a biplanar diode array dosimeter for quality assurance of step-and-shoot IMRT.Email this article to a colleague.
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We described and characterized a novel biplanar diode array, and demonstrated its applicability to dosimetric QA of the step-and-shoot IMRT. It is the first commercially available device of its kind specifically designed for measurements at varying gantry angles. The detector consists of a cylindrical PMMA phantom with two orthogonal detector boards. There are a total of 1069 p-type 1 mm wide diode detectors covering the measurement area of 20 x 20 cm2 in each of the measurement planes. The orthogonal detector arrays ensure that the dose modulation information is not lost regardless of the beam incidence angle. For absolut...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Feygelman V, Forster K, Opp D, Nilsson G Tags: J Appl Clin Med Phys Source Type: journals
Direct machine parameter optimization for intensity modulated radiation therapy (IMRT) of oropharyngeal cancer - a planning study.Email this article to a colleague.
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The purpose of the study was to investigate the potential of direct machine parameter optimization (DMPO) to achieve parotid sparing without compromising target coverage in IMRT of oropharyngeal cancer as compared to fluence modulation with subsequent leaf sequencing (IM) and forward planned 2-step arc therapy (IMAT). IMRT plans were generated for 10 oropharyngeal cancer patients using DMPO and IM. The resulting dose volume histograms (DVH) were evaluated with regard to compliance with the dose volume objectives (DVO) and plan quality. DMPO met the DVO for the targets better than IM but violated the DVO to the parotids...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Dobler B, Koelbl O, Bogner L, Pohl F Tags: J Appl Clin Med Phys Source Type: journals
Characterization of cylindrical ionization chambers for patient specific IMRT QA.Email this article to a colleague.
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Proven conventional dosimetry techniques do not provide accuracy and precision in the measurement of inverse planned intensity modulated radiation therapy (IMRT) fields. Dynamic and step-and-shoot multileaf collimation (DMLC/SMLC) challenge current ionization chamber dosimetry practices. Ionization chamber performance in these fields is evaluated for three cylindrical chambers of varying volumes (PinPoint (PP): 0.015 cm3, IC10: 0.13 cm3, Farmer type NE2571 (FT): 0.69 cm3) in terms of measurement reproducibility, dose measurement linearity, and IMRT dose measurements. Fifty IMRT patient specific quality assurance dose m...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Fraser DJ, Parker W, Seuntjens J Tags: J Appl Clin Med Phys Source Type: journals
Comparison of IMRT planning with two-step and one-step optimization: a strategy for improving therapeutic gain and reducing the integral dose.Email this article to a colleague.
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The aim of this study was to evaluate the effectiveness and efficiency in inverse IMRT planning of one-step optimization with the step-and-shoot (SS) technique as compared to traditional two-step optimization using the sliding windows (SW) technique. The Pinnacle IMRT TPS allows both one-step and two-step approaches. The same beam setup for five head-and-neck tumor patients and dose-volume constraints were applied for all optimization methods. Two-step plans were produced converting the ideal fluence with or without a smoothing filter into the SW sequence. One-step plans, based on direct machine parameter optimization ...
Source: Physics in Medicine and Biology - November 20, 2009 Category: Physics Authors: Abate A, Pressello MC, Benassi M, Strigari L Tags: Phys Med Biol Source Type: journals
Enzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-protein block copolymers.Email this article to a colleague.
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A new approach to prepare functional polymeric micelles in a one step reaction using the unique catalytic property of PHA synthase is described. A biopolymer-based nanocarrier with cancer targeting capability was successfully synthesized from genetically engineered PHA synthase fused with RGD peptide.
PMID: 19920997 [PubMed - as supplied by publisher]
Source: Chemical Communications - November 20, 2009 Category: Chemistry Authors: Kim HN, Lee J, Kim HY, Kim YR Tags: Chem Commun (Camb) Source Type: journals
As many as six tandem reactions in one step! Unprecedented formation of highly functionalized benzothiophenes.Email this article to a colleague.
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A novel reaction pathway involving 1,3-diketones and 2,2'-dithiodibenzoylchloride that gives access to benzothiophenes with spiroketal, lactone, carbonyl, hydroxyl and carboxylic acid functionalities is discussed.
PMID: 19921006 [PubMed - as supplied by publisher]
Source: Chemical Communications - November 20, 2009 Category: Chemistry Authors: Gopinath P, Nilaya S, Debi TR, Ramkumar V, Muraleedharan KM Tags: Chem Commun (Camb) Source Type: journals
A consensus-based template for uniform reporting of data from pre-hospital advanced airway managementEmail this article to a colleague.
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Conclusion: We successfully developed an Utstein-style template for documenting and reporting pre-hospital airway management. The core dataset for this template should be included in future studies on pre-hospital airway management to produce comparable data across systems and patient populations and will be implemented in systems that are influenced by the expert panel.
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - November 20, 2009 Category: Emergency Medicine Authors: step... J M SollidDavid LockeyHans Morten LossiusPre-hospital advanced airway management expert group Paam Source Type: journals
HAMSTER: visualizing microarray experiments as a set of minimum spanning treesEmail this article to a colleague.
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Conclusions:
Researchers may find it helpful to include HAMSTER in their microarray analysis workflow as it can offer insights that differ from hierarchical clustering. We believe that HAMSTER would be useful for certain types of gradient data sets (e.g time-series data) and data that indicate relationships between cells/tissues. Both the source and the web server variant of HAMSTER are available from http://hamster.cbrc.jp/.
Source: Source Code for Biology and Medicine - November 20, 2009 Category: Information Technology Authors: Raymond WanLarisa KiselevaHajime HaradaHiroshi MamitsukaPaul Horton Source Type: journals
Skills for support: personal assistants and people with learning disabilitiesEmail this article to a colleague.
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This paper is about how people get good support. This can happen when you have a direct payment, and you have your own personal assistant (PA). But you need to have a good PA, who knows how to communicate well. Two people with learning disabilities worked in the research team on this project. The team made videos of people with learning disabilities working with their PAs. It is important that the PA knows how to support you well. For instance, they should treat you with respect. This means that you can tell them what to do. They should talk to you like an adult, and listen to what you want. They should not rush you. A goo...
Source: British Journal of Learning Disabilities - November 20, 2009 Category: Disability Authors: Val Williams, Lisa Ponting, Kerrie Ford, Philippa Rudge Source Type: journals
P&G Voluntarily Recalls Specific Lots of Vicks Sinex Nasal Spray in the United States, Germany and the United KingdomEmail this article to a colleague.
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The Procter & Gamble Company (NYSE:PG) announced today it is voluntarily recalling three lots of its Vicks Sinex nasal spray in three countries: the United States, Germany and the United Kingdom. The company said it is taking this precautionary step after finding the bacteria B. cepacia in a small amount of product made at its plant in Gross Gerau, Germany.
Source: Food and Drug Administration - November 19, 2009 Category: Food Science Source Type: organizations
My New New BossEmail this article to a colleague.
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Shuffle Ball change. That's the current dance step in so many offices.It's ironic in a way. With the job market frozen so that even the unhappiest amongst us are advised to take a deep breath and endure for the nonce, some companies are undergoing internal change at an unexpected pace."It's my third boss in two years." said one Assistant Superintendent in a school district where School Superintendents have the life span of fruit flies.‘We merged again." explained a banking investments advisor. "And while I'm singing the grateful-to-have-a-job anthem, which is the god's honest truth, I inherited a boss from the gang that ...
Source: Psychology Today Work Center - November 19, 2009 Category: Psychiatry & Psychology Authors: Dr. Judith Sills Tags: Work anthem assistant superintendent banking investments ceos dance step...ep breath family business fruit flies honest truth life span new boss nonce outsider power structure printing sales repositioning sales director Source Type: consumer
ALLHAT investigators report 10-year follow-up and stand by diuretics as first step antihypertensive treatmentEmail this article to a colleague.
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New 10-year mortality and morbidity data confirm the original trial conclusions, they say, that while amlodipine and lisinopril are not superior to chlorthalidone on any outcome, chlorthalidone is superior to these agents on one or more secondary end points. Full agreement with this conclusion in the community, though, is still hard to come by.
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info
False positive on breast cancer | Sarah WildmanEmail this article to a colleague.
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A panel's recommendation that American women need fewer mammograms would mean more deaths from breast cancerIn the US we've heard the refrain for two decades: early detection saves lives. But this week a federal advisory board decided that while that slogan wasn't false, in the case of breast cancer, it just wasn't true enough. After years of pink ribbons and breast cancer marches and admonishments to examine our breasts, this week the US Preventative Services Task Force bucked conventional wisdom (and the American Cancer Society) claiming that the number of women saved by early detection through mammography was not enough...
Source: Guardian Unlimited Science - November 19, 2009 Category: Science Authors: Sarah Wildman Tags: US healthcare Women Healthcare industry Cancer Obama administration & wellbeing United States World news guardian.co.uk Comment Comment is free Source Type: news
ALLHAT Investigators Report 10-Year Follow-up and Stand by Diuretics as First-Step Antihypertensive TreatmentEmail this article to a colleague.
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New data confirm the original conclusions: although amlodipine and lisinopril are not superior to chlorthalidone on any outcome, chlorthalidone is superior to them on 1 or more secondary endpoints. Medscape Medical News
Source: Medscape Today Headlines - November 19, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news
Complete Characterization of Stable Bandlimited Systems Under Quantization and ThresholdingEmail this article to a colleague.
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In this paper, we analyze the approximation behavior of sampling series, where the sample values—taken equidistantly at Nyquist rate—are disturbed either by the nonlinear threshold operator or the nonlinear quantization operator. We perform the analysis for several spaces of bandlimited signals and completely characterize the spaces for which an approximation is possible. Additionally, we study the approximation of outputs of stable linear time-invariant systems by sampling series with disturbed samples for signals in ${cal PW}_{pi}^{1}$. We show that there exist stable systems that become unstable under thre...
Source: IEEE Transactions on Signal Processing - November 19, 2009 Category: Biomedical Engineering Source Type: journals
Linkage Biosciences Unveils LinkSeqTM -- A Revolutionary New Tool For Immunogenetic TestingEmail this article to a colleague.
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Linkage Biosciences, Inc., a privately held molecular diagnostics company, recently unveiled LinkSeq™ -- a new one-step method for Human Leukocyte Antigen (HLA) testing -- at the annual meeting of the American Society of Histocompatibility and Immunogenetics (ASHI) in San Francisco.
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news
Linkage Biosciences Unveils LinkSeqTM -- A Revolutionary New Tool For Immunogenetic TestingEmail this article to a colleague.
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Linkage Biosciences, Inc., a privately held molecular diagnostics company, recently unveiled LinkSeq™ -- a new one-step method for Human Leukocyte Antigen (HLA) testing -- at the annual meeting of the American Society of Histocompatibility and Immunogenetics (ASHI) in San Francisco. Much faster than other HLA testing methods currently available, LinkSeq™ is a proprietary sequence-specific priming (SSP) chemistry that can be analyzed utilizing real-time PCR platforms.
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Synthesis of Pentafluorophenyl
Esters of Nitroveratryloxycarbonyl-Protected Amino AcidsEmail this article to a colleague.
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SynlettDOI: 10.1055/s-0029-1218369AbstractFor efficient peptide synthesis on a glass chip, 20 kinds of
pentafluorophenyl (Pfp) esters of nitroveratryloxycarbonyl (NVOC)-protected
amino acids were synthesized by using Pfp trifluoroacetate.
Simple purification step gave moderate to high yield. The first
loading time of each amino acid on glass surface was 30-60
min. The UV cleavage of the NVOC group was completed within 10 minutes.[...]© Georg Thieme Verlag
Stuttgart ˙ New YorkGet connected:Table of contents | Abstract | Full text
Source: Synlett - November 19, 2009 Category: Chemistry Tags: letter Source Type: journals
Maternal Mortality Halved in Eastern Europe and Central Asia, but Too Many Women Still Die Giving Life - 12 November 2009Email this article to a colleague.
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ISTANBUL – Decision-makers and government officials from 20 countries in Eastern Europe and Central Asia have pledged to step up the fight against needless deaths and suffering resulting from pregnancy and childbirth. In a Statement of Commitment issued in Istanbul late last night, delegates to a high-level meeting recognized that investment in the health and rights of women is smart economics, especially during a financial crisis, and that family planning is one of the most cost-effective investments in reducing the maternal deaths that continue to affect the region.
Source: UNFPA News - November 19, 2009 Category: Global & Universal Source Type: organizations
Thermal Ablation of Osteoid Osteoma: Overview and Step-by-Step Guide [RSNA Education Exhibits]Email this article to a colleague.
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The indications, contraindications, and possible complications of using radiofrequency ablation to treat osteoid osteoma are discussed, with emphasis on a detailed step-by-step guide to preprocedural preparations, procedural technique, and postprocedural care.
Source: Radiographics recent issues - November 19, 2009 Category: Radiology Authors: Motamedi, D., Learch, T. J., Ishimitsu, D. N., Motamedi, K., Katz, M. D., Brien, E. W., Menendez, L. Tags: Musculoskeletal Radiology, Vascular and/or Interventional Radiology RSNA Education Exhibits Source Type: journals
Clinical Use of Resorbable Polymeric Membranes in the Treatment of Bone DefectsEmail this article to a colleague.
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The reconstruction of large bone defects remains a clinically challenging condition. Although many treatment approaches exist, they all have limitations. Recently, bioresorbable polylactide membranes have become commercially available. These membranes, when applied to bone defects, enhance bone healing by direct osteoconduction, exclusion of nonosseous tissues, and enhancing the osteogenic environment for autologous grafts. When combined with appropriate internal fixation and autologous bone graft, bioresorbable polylactide membranes allow for single-step reconstruction of large bone defects.
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Richard P. Meinig Source Type: journals
Gold η2-Coordination to Unsaturated and Aromatic Hydrocarbons: The Key Step in Gold-Catalyzed Organic TransformationsEmail this article to a colleague.
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Organometallics, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable).
Source: Organometallics - November 19, 2009 Category: Chemistry Tags: article Source Type: journals
Also In Global Health News: Sleeping Sickness; Aid For Philippines; U.S., China In Africa; Polio Eradication In Afghanistan; Ethiopia FamineEmail this article to a colleague.
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Lancet Infectious Diseases Examines Hold-Ups In Implementation Of Sleeping Sickness Therapy Lancet Infectious Diseases Newsdesk examines how despite evidence that a new therapy to treat sleeping sickness, called nifurtimox-eflornithine (NECT) is a step forward in treating the
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Tropical Diseases Source Type: news
CytRx To Initiate Phase 2 Clinical Trial With INNO-206 In Patients With Advanced Gastric CancerEmail this article to a colleague.
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CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical company, today announced plans to initiate an open-label, multinational Phase 2 clinical trial with its doxorubicin prodrug INNO-206 as a second-line treatment in patients with advanced gastric (stomach) cancer. CytRx President and CEO Steven A. Kriegsman said, "This planned clinical trial is a key step forward in our plans to build a commercial oncology franchise for CytRx.
Source: Cancer / Oncology News From Medical News Today - November 19, 2009 Category: Cancer & Oncology Tags: Cancer / Oncology Source Type: news
As women ageEmail this article to a colleague.
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In a step toward using human saliva to tell whether those stiff joints, memory lapses, and other telltale signs of aging are normal or red flags for disease, researchers are describing how the protein content of women's saliva change with advancing age. The discovery could lead to a simple, noninvasive test for better diagnosing and treating certain age-related diseases in women, they suggest in a report in ACS' Journal of Proteome Research, a monthly publication. These diseases include lupus, Sjgrens syndrome (linked to dry mouth and dry eye), and other immune-related disorders that affect millions of women worldwide, oft...
Source: Medicineworld.org: New Article Alert - November 19, 2009 Category: Consumer Health News Source Type: info
New research into the mechanisms of gene regulationEmail this article to a colleague.
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(Penn State) A team of scientists led by Penn State's Ross Hardison has taken a large step toward unraveling how regulatory proteins control the production of gene products during development and growth. They focused specifically on the complex process of producing red blood cells (erythrocytes). These cells contain large amounts of hemoglobin, a molecule essential for transporting oxygen throughout the body. The research results could help in the development of important new therapies to combat sickle-cell disease.
Source: EurekAlert! - Medicine and Health - November 19, 2009 Category: Global & Universal Source Type: news
New findings suggest strategy to help generate HIV-neutralizing antibodiesEmail this article to a colleague.
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(NIH/National Institute of Allergy and Infectious Diseases) New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.
Source: EurekAlert! - Medicine and Health - November 19, 2009 Category: Global & Universal Source Type: news
Sweet -- sugared polymer a new weapon against allergies and asthmaEmail this article to a colleague.
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(Johns Hopkins Medical Institutions) Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks. Their advance is a significant step toward crafting pharmaceuticals to fight these often life-endangering conditions in a new way.
Source: EurekAlert! - Medicine and Health - November 19, 2009 Category: Global & Universal Source Type: news
Molecular Targets in Malignant Pleural Mesothelioma Treatment.Email this article to a colleague.
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Malignant mesothelioma is an aggressive tumour of the serosal surfaces with poor prognosis and increasing incidence due to widespread previous asbestos exposure. Relative chemotherapeutic and radiotherapeutic resistance makes malignant pleural mesothelioma (MPM) difficult to manage, even though encouraging results were achieved with multimodality treatment. Better knowledge of angiogenesis and molecular pathways involved in MPM seems to be the right way to define new targets for systemic treatment. Neoangiogenesis may be considered as a critical step in the development of mesothelioma. Vascular endothelial growth facto...
Source: Current Drug Targets - November 19, 2009 Category: Drugs & Pharmacology Authors: Pasello G, Favaretto A Tags: Curr Drug Targets Source Type: journals
Comparing objective measures of environmental supports for pedestrian travel in adultsEmail this article to a colleague.
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Conclusion:
Among three methods of aggregation examined, the method that accounted for distance from participant's home to the pedestrian facility (distance weighting) is promising; at the same time, it requires the most time and effort to calculate. This finding is consistent with the behavioral assumption that travelers may respond to environmental features closer to their residence more strongly than to more distant environmental qualities.
Source: International Journal of Health Geographics - November 19, 2009 Category: Global & Universal Authors: Elizabeth ShayDaniel RodriguezGihyoug ChoKelly CliftonKelly Evenson Source Type: journals
[Development of pediatric surgery in the next 20 years.]Email this article to a colleague.
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Pediatric surgery focuses not on an anatomic region or organ system, but on the development of a growing human being according to age. Recently, a tendency to reduce and to downgrade pediatric surgery could be observed which is due to economic reasons and an alarming lack of trained surgeons. Just as 60 years ago, general surgeons continue to operate on infants and children. However, this is a step backwards and an anachronism. Children are not small adults and pediatric surgery can be distinguished from adult surgery in many aspects, such as the spectrum of surgical diseases, the congenital malformations and frequentl...
Source: Der Chirurg - November 19, 2009 Category: Surgery Authors: Barthlen W Tags: Chirurg Source Type: journals
A systematic association mapping on chromosome 6q in bipolar affective disorder - evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorderEmail this article to a colleague.
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Strong evidence of linkage between chromosomal region 6q16-q22 and bipolar affective disorder (BPAD) has previously been reported. We conducted a systematic association mapping of the 6q-linkage interval using 617 SNP markers in a BPAD case-control sample of German descent (cases = 330, controls = 325). In this screening step, 46 SNPs showed nominally significant BPAD-association (P-values between 0.0007 and 0.0484). Although none of the 46 SNPs survived correction for multiple testing, they were genotyped in a second and ethnically matched BPAD sample (cases = 328, controls = 397). At the melanin-concentrating-hormone-rec...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 19, 2009 Category: Genetics & Stem Cells Authors: Rami Abou Jamra, Thomas G. Schulze, Tim Becker, Felix F. Brockschmidt, Elaine Green, Margrieta A. Alblas, Jens R. Wendland, Mazda Adli, Detelina Grozeva, Jana Strohmeier, Alexander Georgi, Nick Craddock, Peter Propping, Marcella Rietschel, Markus M. Nöth Source Type: journals
Dynamic Model for Predicting Death Within 12 Months in Patients With Primary or Post-Polycythemia Vera/Essential Thrombocythemia Myelofibrosis [Hematologic Malignancies]Email this article to a colleague.
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Conclusion
Blood or bone marrow blasts ≥ 10%, platelets less than 50 x 109/L, and chromosome 17 aberrations defined AP in patients with MF. Patients in AP should be candidates for intensive therapeutic interventions.
Source: Journal of Clinical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Tam, Kantarjian, Cortes, Lynn, Pierce, Zhou, Keating, Thomas, Verstovsek Tags: Diagnosis & Staging Hematologic Malignancies Source Type: journals
HIV-1 STEP Vaccine Trial Failure Blamed on Adenovirus ShellEmail this article to a colleague.
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The increase in HIV infections among vaccines, leading to a halt of the HIV type 1 STEP vaccine trial, has been traced to the adenovirus shell. Medscape Medical News
Source: Medscape Today Headlines - November 18, 2009 Category: Consumer Health News Tags: HIV/AIDS Source Type: news
ONLINE MINDFULNESS MEDITATION THERAPY FOR STRESS MANAGEMENTEmail this article to a colleague.
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The single major cause of emotional suffering and stress in our lives comes from the accumulated habitual emotional reactions to life events that we acquire through unconscious learning. We become victims of recurrent negative thoughts and patterns of emotional reactivity that operate automatically in the mind, and that operate outside the sphere of conscious choice. We become prisoners of our habitual thinking and suffer accordingly. Therefore, it stands to reason that if we want to reduce our level of emotional stress and suffering, we must learn new strategies to counteract and neutralize our conditioned habitual reacti...
Source: Psychology Today Relationships Center - November 18, 2009 Category: Psychiatry & Psychology Authors: Peter Strong, Ph.D. Tags: Anxiety Cognition Depression Happiness Relationships Self-Help Stress Therapy Work coffee maker conscious choice core level correspondence driving seat emotional reactions emotional reactivity emotional stress emotions Source Type: consumer
The Population Genetics of Adaptation: Multiple Substitutions on a Smooth Fitness Landscape [Population and evolutionary genetics]Email this article to a colleague.
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Much recent work in the theoretical study of adaptation has focused on the so-called strong selection–weak mutation (SSWM) limit, wherein adaptation is due to new mutations of definite selective advantage. This work, in turn, has focused on the first step (substitution) during adaptive evolution. Here we extend this theory to allow multiple steps during adaptation. We find analytic solutions to the probability that adaptation follows a certain path during evolution as well as the probability that adaptation arrives at a given genotype regardless of the path taken. We also consider the probability of parallel adaptati...
Source: Genetics - November 18, 2009 Category: Genetics & Stem Cells Authors: Unckless, R. L., Orr, H. A. Tags: Population and evolutionary genetics Source Type: journals
Interlock Formation and Coiling of Meiotic Chromosome Axes During Synapsis [Cellular genetics]Email this article to a colleague.
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The meiotic prophase chromosome has a unique architecture. At the onset of leptotene, the replicated sister chromatids are organized along an axial element. During zygotene, as homologous chromosomes pair and synapse, a synaptonemal complex forms via the assembly of a transverse element between the two axial elements. However, due to the limitations of light and electron microscopy, little is known about chromatin organization with respect to the chromosome axes and about the spatial progression of synapsis in three dimensions. Three-dimensional structured illumination microscopy (3D-SIM) is a new method of superresolution...
Source: Genetics - November 18, 2009 Category: Genetics & Stem Cells Authors: Wang, C.-J. R., Carlton, P. M., Golubovskaya, I. N., Cande, W. Z. Tags: Cellular genetics Source Type: journals
A Combinatorial Interplay Among the 1-Aminocyclopropane-1-Carboxylate Isoforms Regulates Ethylene Biosynthesis in Arabidopsis thaliana [Developmental and behavioral genetics]Email this article to a colleague.
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Ethylene (C2H4) is a unique plant-signaling molecule that regulates numerous developmental processes. The key enzyme in the two-step biosynthetic pathway of ethylene is 1-aminocyclopropane-1-carboxylate synthase (ACS), which catalyzes the conversion of S-adenosylmethionine (AdoMet) to ACC, the precursor of ethylene. To understand the function of this important enzyme, we analyzed the entire family of nine ACS isoforms (ACS1, ACS2, ACS4-9, and ACS11) encoded in the Arabidopsis genome. Our analysis reveals that members of this protein family share an essential function, because individual ACS genes are not essential for Arab...
Source: Genetics - November 18, 2009 Category: Genetics & Stem Cells Authors: Tsuchisaka, A., Yu, G., Jin, H., Alonso, J. M., Ecker, J. R., Zhang, X., Gao, S., Theologis, A. Tags: Developmental and behavioral genetics Source Type: journals
