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Components of the complete blood count as risk predictors for coronary heart disease: in-depth review and update.
Abstract Atherosclerosis is an inflammatory disease, and several inflammatory biomarkers, such as C-reactive protein, have been used to predict the risk of coronary heart disease. High white blood cell count is a strong and independent predictor of coronary risk in patients of both sexes, with and without coronary heart disease. A high number of white blood cells and their subtypes (for example, neutrophils, monocytes, lymphocytes, and eosinophils) are associated with the presence of coronary heart disease, peripheral arterial disease, and stroke. The coronary heart disease risk ratios associated with a high white ...
Source: Texas Heart Institute Journal - May 25, 2013 Category: Cardiology Authors: Madjid M, Fatemi O Tags: Tex Heart Inst J Source Type: research
Acute aortic dissection and stroke in multivessel fibromuscular dysplasia.
We report a rare case of multivessel fibromuscular dysplasia manifested by acute stroke in association with type I aortic dissection, which progressed rapidly to ascending aortic false aneurysmal development that necessitated arch replacement. Outcomes of aortic arch replacement in this setting are currently unknown. Therefore, our case might well offer some insight. PMID: 23467036 [PubMed - in process] (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - May 25, 2013 Category: Cardiology Authors: Kar S, Gopaldas RR, Kumar A Tags: Tex Heart Inst J Source Type: research
The effect of denture cleansers on resiliency of soft lining materials.
Conclusion: Heat processed soft liners recover faster/better in a shorter time interval when compared to self-processed liners which takes longer time for the recovery. This time period is very important as the cushioning effect of the soft liner require an elastic recovery between the masticatory strokes. Clinical implications: Greater the softness and better the elastic recovery of the denture soft liner, more effective would be its performance clinically. Silicon based material, such as Molloplast-B, rebounds quickly and would seem preferable to a material that is acrylic based. It is possible that, if the response is t...
Source: J Contemp Dent Pract - May 24, 2013 Category: Dentistry Authors: Rao AK, Kumar S, Reddy NA, Reddy NS Tags: J Contemp Dent Pract Source Type: research
Usefulness of vascular wall deformation for assessment of carotid arterial stiffness and association with previous stroke in elderly.
CONCLUSIONS: Carotid wall deformation indices are useful for assessment of local carotid arterial stiffness. CS and CSR of carotid artery measured by speckle tracking techniques were associated with previous ischemic stroke in the elderly. PMID: 23479072 [PubMed - in process] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - May 24, 2013 Category: Cardiology Authors: Tsai WC, Sun YT, Liu YW, Ho CS, Chen JY, Wang MC, Tsai LM Tags: Am J Hypertens Source Type: research
Disproportionate pregnancy-induced myocardial hypertrophy in women with essential hypertension.
CONCLUSIONS: Hypertension and pregnancy have a synergistic effect on ventricular remodeling, which elevates a woman's risk of myocardial hypertrophy. PMID: 23475699 [PubMed - in process] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - May 24, 2013 Category: Cardiology Authors: Zanati Bazan SG, Borges VM, Martin LC, Magalhães CG, Hueb JC, de Arruda Silveira LV, Peraçoli JC, Matsubara BB Tags: Am J Hypertens Source Type: research
Rivaroxaban Gains Approval In Europe For ACS Indication
Rivaroxaban (Xarelto, Bayer) has been approved in Europe for the prevention of atherothrombotic events (cardiovascular death, myocardial infarction or stroke) following an acute coronary syndrome (ACS). The drug was approved at a dose of 2.5 mg twice-daily and should be used in combination with standard antiplatelet therapy. Rivaroxaban is now the only oral anticoagulant to receive an ACS indication. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - May 24, 2013 Category: Pharmaceuticals Authors: Larry Husten Source Type: news
In-hospital strokes get worse care than those presenting to ER, study finds
There are time-tested protocols for responding to strokes in the emergency department, says one observer, but "we just haven't worked it out for the inpatient setting because it's much less common." (Source: theHeart.org)
Source: theHeart.org - May 24, 2013 Category: Cardiology Source Type: news
Clinical guidelines for acute stroke management: Which recommendations should remain consensus-based?
This study investigated stroke clinicians' and academics' opinions about which consensus-based recommendations from the Australian National Stroke Foundation Clinical Guidelines for Acute Stroke Management (2007) should remain as such, using a self-administered questionnaire. In the study, 43 people participated (62% response rate). Of the 50 recommendations presented, at least half the participants believed that 35 (70%) of these should remain consensus-based. In an adjusted multivariable analysis, recommendations perceived to be “highly likely” or “likely” to have an impact on patient outcomes were less likely t...
Source: Journal of Vascular Nursing - May 24, 2013 Category: Nursing Authors: Sandy Middleton, Julianne Rowley, Sharon Hillege, Kelvin Hill, Leonid Churilov, Nissa Allnutt Tags: Articles Source Type: research
Carotid artery endarterectomy: A multidisciplinary approach to improving resource utilization and quality assurance
An estimated 780,000 people in the United States have a stroke each year. Carotid endarterectomy (CEA) is the most frequently performed surgical procedure to prevent the occurrence of stroke. Over the past several years, physicians, nurses, and allied healthcare workers have been challenged to perform this operation in a cost-effective manner without compromising clinical outcomes. At Maine Medical Center (MMC), Portland, Maine, an average of 250 CEAs are performed annually. As part of a quality-assurance initiative, MMC key stakeholders redesigned the care of patients undergoing CEA surgery. A critical pathway supported b...
Source: Journal of Vascular Nursing - May 24, 2013 Category: Nursing Authors: Jill A. Knutson, Carol Jo Morse, Jens Eldrup-Jorgensen, Margaret Estee, Lois Hayworth, Tara A. Herman, Angela S. Vereshko Tags: Articles Source Type: research
A systematic review of the effectiveness of bowel management strategies for constipation in adults with stroke
Conclusion: Constipation management strategies are limited. This review suggests that structured bowel programmes and nurse-led intervention in bowel care have a significant effect in improving bowel evacuations. (Source: International Journal of Nursing Studies)
Source: International Journal of Nursing Studies - May 24, 2013 Category: Nursing Authors: Su Fee Lim, Charmaine Childs Tags: Reviews and Discussion Papers Source Type: research
Outcomes of invasive treatment in very elderly Polish patients with non-ST-segment-elevation myocardial infarction from 2003-2009 (from the PL-ACS registry).
CONCLUSIONS: Elderly patients with NSTEMI benefit significantly from invasive strategies and modern pharmacotherapy recommended by treatment guidelines. Nevertheless, this approach is associated with an increased incidence of major bleeding. PMID: 23558809 [PubMed - in process] (Source: Cardiology Journal)
Source: Cardiology Journal - May 24, 2013 Category: Cardiology Authors: Gierlotka M, Gąsior M, Tajstra M, Hawranek M, Osadnik T, Wilczek K, Kalarus Z, Lekston A, Zembala M, Poloński L Tags: Cardiol J Source Type: research
Influence of aerobic training on neurohormonal and hemodynamic responses to head-up tilt test and on autonomic nervous activity at rest and after exercise in patients after bypass surgery.
CONCLUSIONS: Aerobic training improved neurohormonal and hemodynamic responses to head-up tilt test and favorably modified sympatho-vagal balance in low risk post-CABG patients. PMID: 23558806 [PubMed - in process] (Source: Cardiology Journal)
Source: Cardiology Journal - May 24, 2013 Category: Cardiology Authors: Bilińska M, Kosydar-Piechna M, Mikulski T, Piotrowicz E, Gąsiorowska A, Piotrowski W, Nazar K, Piotrowicz R Tags: Cardiol J Source Type: research
Stroke costs to double by 2030: AHA statement
The statement calls for greater awareness of this "looming crisis" by policy makers at all levels of governance so that practical ways to avert it can be considered. (Source: theHeart.org)
Source: theHeart.org - May 24, 2013 Category: Cardiology Source Type: news
[Articles] Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials
There was no evidence that patients with ischaemic stroke who were at higher risk of thrombotic events or lower risk of haemorrhagic events benefited from heparins. We were therefore unable to define a targeted approach to select the patients who would benefit from treatment with early anticoagulant therapy. We recommend that guidelines for routine or selective use of heparin in stroke should be revised. (Source: Lancet Neurology)
Source: Lancet Neurology - May 24, 2013 Category: Neurology Authors: William N Whiteley, Harold P Adams, Philip MW Bath, Eivind Berge, Per Morten Sandset, Martin Dennis, Gordon D Murray, Ka-Sing Lawrence Wong, Peter AG Sandercock Tags: Articles Source Type: research
[Review] Non-pharmacological strategies for the treatment of acute ischaemic stroke
Early recanalisation and an increase in collateral blood supply are predictors of favourable outcome in acute ischaemic stroke. Since individual responses to intravenous treatment with alteplase are heterogeneous, additional intra-arterial thrombolytic and mechanical endovascular treatment is increasingly given. Despite encouraging findings from single-centre studies, data from randomised clinical trials have not proven the hypothesis that interventional recanalisation leads to a better outcome. Advanced thrombectomy devices, the effect of ultrasound-enhanced thrombolysis, and imaging-guided selection of patients outside t...
Source: Lancet Neurology - May 24, 2013 Category: Neurology Authors: Michael G Hennerici, Rolf Kern, Kristina Szabo Tags: Review Source Type: research
[Review] Streamlining of prehospital stroke management: the golden hour
Thrombolysis with alteplase administered within a narrow therapeutic window provides an effective therapy for acute ischaemic stroke. However, mainly because of prehospital delay, patients often arrive too late for treatment, and no more than 1–8% of patients with stroke obtain this treatment. We recommend that all links in the prehospital stroke rescue chain must be optimised so that in the future more than a small minority of patients can profit from time-sensitive acute stroke therapy. Measures for improvement include continuous public awareness campaigns, education of emergency medical service personnel, the use of s...
Source: Lancet Neurology - May 24, 2013 Category: Neurology Authors: Klaus Fassbender, Clotilde Balucani, Silke Walter, Steven R Levine, Anton Haass, James Grotta Tags: Review Source Type: research
[Review] Movement disorders in cerebrovascular disease
Movement disorders can occur as primary (idiopathic) or genetic disease, as a manifestation of an underlying neurodegenerative disorder, or secondary to a wide range of neurological or systemic diseases. Cerebrovascular diseases represent up to 22% of secondary movement disorders, and involuntary movements develop after 1–4% of strokes. Post-stroke movement disorders can manifest in parkinsonism or a wide range of hyperkinetic movement disorders including chorea, ballism, athetosis, dystonia, tremor, myoclonus, stereotypies, and akathisia. (Source: Lancet Neurology)
Source: Lancet Neurology - May 24, 2013 Category: Neurology Authors: Raja Mehanna, Joseph Jankovic Tags: Review Source Type: research
[Comment] Anticoagulant therapy in acute brain ischaemia
Thrombosis plays an important part in acute ischaemic stroke, and antithrombotic therapies are a logical approach to treatment. Heparin has been advocated for acute stroke since the 1950s, and by the 1980s, patients with acute ischaemic stroke and transient ischaemic attack were routinely treated with intravenous heparin with the aim of reducing progression of ischaemia and preventing early stroke recurrence. Since then, multiple randomised trials have tested heparins (unfractionated heparin, low-molecular-weight heparin, and heparinoids) and other anticoagulants in acute stroke. (Source: Lancet Neurology)
Source: Lancet Neurology - May 24, 2013 Category: Neurology Authors: John W Eikelboom, Robert G Hart Tags: Comment Source Type: research
Clinical predictors to identify paroxysmal atrial fibrillation after ischaemic stroke
ConclusionsIn acute stroke patients with advanced age, history of coronary artery disease and clinical symptoms >24 h, a prolonged Holter ECG monitoring and follow‐up is warranted to identify pAF. This could increase the detection rate of patients requiring anticoagulation and may be able to reduce the risk of recurrent stroke in the case of successful anticoagulation of these patients. (Source: European Journal of Neurology)
Source: European Journal of Neurology - May 24, 2013 Category: Neurology Authors: J. Wohlfahrt, R. Stahrenberg, M. Weber‐Krüger, S. Gröschel, K. Wasser, F. Edelmann, J. Seegers, R. Wachter, K. Gröschel Tags: Original Article Source Type: research
A double‐blind placebo‐controlled clinical evaluation of MultiStem for the treatment of ischemic stroke
Conclusions and future directionIf MultiStem is safe and there is a signal of efficacy, a late stage phase IIb‐III trial is planned. (Source: International Journal of Stroke)
Source: International Journal of Stroke - May 24, 2013 Category: Neurology Authors: David C. Hess, Cathy A. Sila, Anthony J. Furlan, Larry R. Wechsler, Jeffrey A. Switzer, Robert W. Mays Tags: Protocols Source Type: research
Bee venom acupuncture point injection for central post stroke pain: A preliminary single-blind randomized controlled trial.
CONCLUSION: Apipuncture significantly improved CPSP in this pilot trial. Further studies of its mechanisms and a larger and long-term follow-up trial will be needed to determine more definitely the efficacy of apipuncture and to elucidate duration of improvement. PMID: 23642945 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - May 24, 2013 Category: Complementary Medicine Authors: Cho SY, Park JY, Jung WS, Moon SK, Park JM, Ko CN, Park SU Tags: Complement Ther Med Source Type: research
Well: Mind: Depression and Stroke Risk
Being depressed is known to increase the risk for stroke. Now a new study suggests that the association is even stronger in younger women. (Source: NYT Health)
Source: NYT Health - May 24, 2013 Category: Consumer Health News Authors: By NICHOLAS BAKALAR Tags: depression Stroke Mind Featured Source Type: news
Bayer’s Xarelto® Approved in the EU for Secondary Prevention after an Acute Coronary Syndrome (for specialized target groups only)
Following an ACS event, one in ten patients will have another major atherothrombotic event (cardiovascular death, myocardial infarction or stroke) within a year / Xarelto 2.5 mg BID in combination with antiplatelet therapy can help prevent athero-thrombotic events by providing more complete protection than antiplatelet therapy alone / Xarelto is approved to protect patients from blood clots across more venous and arterial thromboembolic conditions than any other novel oral anticoagulant (Source: Bayer Company News)
Source: Bayer Company News - May 24, 2013 Category: Pharmaceuticals Source Type: news
[Editorial] Salt: friend or foe?
Dietary guidelines advise against the consumption of too much salt. A high intake of sodium causes raised blood pressure—an established risk factor for heart disease, stroke, and kidney disease. But how much salt is too much? And could a very low salt intake also be detrimental? (Source: LANCET)
Source: LANCET - May 24, 2013 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research
Plethysmographic Variability Index (PVI) accuracy in predicting fluid responsiveness in anesthetized children.
This study found both PVI and prechallenge SVI to be accurate when used to predict fluid load response during anesthetized noncardiac surgery in children. However, a third of recorded PVI values were inconclusive. PMID: 23521073 [PubMed - in process] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - May 24, 2013 Category: Anesthesiology Authors: Julien F, Hilly J, Sallah TB, Skhiri A, Michelet D, Brasher C, Varin L, Nivoche Y, Dahmani S Tags: Paediatr Anaesth Source Type: research
[Aphasia, prosopagnosia and mania: a case diagnosed with right temporal variant semantic dementia].
Abstract Neurologic disorders can produce "secondary" mania, and clinicians must distinguish secondary mania from bipolar disorders (BD). Patients with new and late onset mania require an evaluation that includes a thorough history, a neurologic examination, neuroimaging, and other selected tests. Neurologic causes of mania include strokes in the right basotemporal or inferofrontal region, strokes or tumors in the perihypothalamic region, Huntington's disease and other movement disorders, multiple sclerosis and other white matter diseases, head trauma, infections such as neurosyphilis and Creutzfeldt-Jakob disease,...
Source: Turkish Journal of Psychiatry - May 24, 2013 Category: Psychiatry Authors: Turan Ç, Kesebir S, Meteris H, Ülker M Tags: Turk Psikiyatri Derg Source Type: research
Implementing a framework for goal setting in community based stroke rehabilitation: a process evaluation
Conclusions: G-AP has been perceived as both beneficial and broadly acceptable in one community rehabilitation team; however, implementation of novel aspects of the framework was inconsistent. The regulatory function of goal non-attainment and the importance of creating flexible partnerships with patients have been highlighted. Further development of the G-AP framework, training package and patient held record is required to address the specific issues highlighted by this process evaluation. Further evaluation of G-AP is required across diverse community rehabilitation settings. (Source: BMC Health Services Research)
Source: BMC Health Services Research - May 24, 2013 Category: Journals (General) Authors: Lesley ScobbieDonald McLeanDiane DixonEdward DuncanSally Wyke Source Type: research
Major bleeding in patients with atrial fibrillation receiving vitamin K antagonists: a systematic review of randomized and observational studies
Conclusion The median rate of major bleeding in observational studies and RCTs is similar. The larger heterogeneity in bleeding rates observed in a real-life setting could reflect a high variability in standard of care of patients on VKAs and/or methodological differences between observational studies and/or variability in data sources. (Source: Europace)
Source: Europace - May 24, 2013 Category: Cardiology Authors: Roskell, N. S., Samuel, M., Noack, H., Monz, B. U. Tags: Atrial Fibrillation Source Type: research
Sleeping over a sleep disorder - Awareness of obstructive sleep apnoea as a modifiable risk factor for hypertension and stroke: A survey among health care professionals and medical students
Conclusion: This study reveals dismal level of awareness, among health professionals and medical students, about OSA being an established and modifiable risk factor for hypertension and ischemic stroke. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - May 24, 2013 Category: Neurology Authors: Sushma SharmaPR Srijithesh Source Type: research
Transcranial doppler: Technique and common findings (Part 1)
This article describes the basic ultrasound physics pertaining to TCD insonation methods, for detecting the flow in intracranial vessels in addition to the normal and abnormal spectral flow patterns. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - May 24, 2013 Category: Neurology Authors: Lokesh BathalaMan Mohan MehndirattaVijay K Sharma Source Type: research
Study to assess the effectiveness of modified constraint-induced movement therapy in stroke subjects: A randomized controlled trial
Conclusion: There is a significant improvem ent in upper extremity function so it indicates that m-CIMT is effective in improving the motor function of the affected arm in stroke subjects. However, its long-term effect has not proved since there was no follow-up after intervention. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - May 24, 2013 Category: Neurology Authors: Priyanka SinghBijayeta Pradhan Source Type: research
Relation of glycated hemoglobin with carotid atherosclerosis in ischemic stroke patients: An observational study in Indian population
Conclusions: Prediction of future risk and prevention strategies for ischemic stroke could be formulated by utilizing HbA 1 c levels in both diabetic and non-diabetic population. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - May 24, 2013 Category: Neurology Authors: Amit Shankar SinghVirendra AtamShyam Chand ChaudharyKamal Kumar SawlaniMunna Lal PatelSameer SarafBesthenahalli Erappa YathishLiza Das Source Type: research
The relationship of flow velocities to vessel diameters differs between extracranial carotid and vertebral arteries of stroke patients
ConclusionsOur study demonstrated different diameter/flow relationships in the carotid and the vertebral arteries of stroke patients, which may suggest pathologic changes in the adaptive processes governing vessel diameter and growth, especially in the carotid arteries. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 2013; (Source: Journal of Clinical Ultrasound)
Source: Journal of Clinical Ultrasound - May 24, 2013 Category: Radiology Authors: Mayowa O. Owolabi, Atinuke M. Agunloye, Adesola Ogunniyi Tags: Research Article Source Type: research
Effectiveness of micron‐sized superparamagnetic iron oxide particles as markers for detection of migration of bone marrow‐derived mesenchymal stromal cells in a stroke model
Conclusion:This study suggests that the use of MPIOs as labeling agents are insufficient to conclusively determine the localization of iron within cells in regions of neuronal ischemia and hemorrhage. J. Magn. Reson. Imaging 2013;37:1409–1418. © 2012 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - May 24, 2013 Category: Radiology Authors: Emidio Tarulli, Joydeep D. Chaudhuri, Voytek Gretka, Amy Hoyles, Cindi M. Morshead, G.J. Stanisz Tags: Original Research Source Type: research
Metastatic undifferentiated pleomorphic sarcoma causing intraoperative stroke.
We report a case of a dedifferentiated liposarcoma that metastasized to the lung within one year. The histologic morphology of the metastasis was more aggressive than the primary lesion, and was consistent with a pleomorphic undifferentiated sarcoma. Following surgical resection of the metastatic pulmonary lesion, the patient never fully regained consciousness. He expired the day following his surgery. At autopsy, the patient was found to have died from a massive hemorrhagic stroke involving almost the entire left cerebrum. Tumor emboli from the pulmonary metastasis were seen in the left middle cerebral artery, causing the...
Source: Annals of Clinical and Laboratory Science - May 23, 2013 Category: Laboratory Medicine Authors: Spaulding R, Koumoundouros T, Parker JC Tags: Ann Clin Lab Sci Source Type: research
Hemifacial spasm and recurrent stroke due to vertebrobasilar dolichoectasia coexisting with saccular aneurysm of the basilar artery: a case report.
We describe a patient presented with sequential events of hemifacial spasm, cerebral infarction and fatal subarachnoid hemorrhage. All of them are seemingly separate entities. Radiological examination revealed that the cause was vertebrobasilar dolichoectasia (VBD) coexisting with a giant saccular aneurysm of basilar artery. VBD is a dilatation and elongation of vertebral artery (VA) and basilar artery (BA) which is of different mechanism from saccular aneurysm. The condition is very rare and its progression may result in compression of brainstem and cranial nerves, ischemic and/or hemorrhagic stroke. The treatment of such...
Source: Turkish Neurosurgery - May 23, 2013 Category: Neurosurgery Authors: Yuan F, Lin J, Ding L, Chao Y, Wenke L, Heng Z Tags: Turk Neurosurg Source Type: research
Sparking Innovation: Patients First, Mice SecondSparking Innovation: Patients First, Mice Second
Robert E. Gerszten, MD, discusses the new Massachusetts General Hospital Institute for Heart, Vascular and Stroke Care and its exciting holistic research program. Medscape Cardiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2013 Category: Consumer Health News Tags: Cardiology Commentary Source Type: news
Erythropoietin Receptor (EpoR) Agonism Is Used to Treat a Wide Range of Disease.
Abstract The erythropoietin receptor (EpoR) was discovered and described in red blood cells (RBCs), stimulating its proliferation and survival. The target in humans for EpoR agonists drugs appears clear-to treat anemia. However, there is evidence of the pleitropic actions of erythropoietin (Epo). For that reason, rhEpo therapy was suggested as a reliable approach for treating a broad range of pathologies, including heart and cardiovascular diseases, neurodegenerative disorders (Parkinson's and Alzheimer's disease), spinal cord injury, stroke, diabetic retinopathy and rare diseases (Friedreich ataxia). Unfortunately...
Source: Molecular Medicine - May 23, 2013 Category: Molecular Biology Authors: Sanchis-Gomar F, Perez-Quilis C, Lippi G Tags: Mol Med Source Type: research
Thermal and hemodynamic response to whole-body cryostimulation in healthy subjects.
In conclusion, the present findings suggest that WBC strongly stimulates the baroreceptor cardiac reflex in response to body fluid changes which sequentially modulate HR and BP control in supine and resting healthy subjects. The study was performed on randomized and homogenic group of young healthy subjects. Our findings are important for WBC safety determination in research and clinical studies. PMID: 23535554 [PubMed - in process] (Source: Cryobiology)
Source: Cryobiology - May 23, 2013 Category: Biology Authors: Zalewski P, Klawe JJ, Pawlak J, Tafil-Klawe M, Newton J Tags: Cryobiology Source Type: research
Decreased Stroke When Avoiding Aortic Manipulation – An Updated Meta-Analysis
Introduction: Neurological injury is a devastating complication of coronary artery bypass grafting (CABG) and is its ‘Achilles Heel’ when compared to percutaneous coronary intervention (PCI). The mechanisms of stroke after CABG are multifactorial but includes embolisation of calcified atherosclerotic plaque from the ascending aorta. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - May 23, 2013 Category: Cardiology Authors: J.J.B. Edelman, T.D. Yan, M.K. Wilson, P.G. Bannon, M.P. Vallely Tags: Abstracts Source Type: research
Kocuria kristinae endocarditis related to diabetic foot infection.
We report an unusual case of endocarditis occurring in a 74-year-old man with a history of systemic hypertension, diabetes mellitus and minor amputation for left forefoot ulcer. The patient was hospitalized for vacuum-assisted closure therapy to aid in wound healing. After the first treatment session, the patient reported abdominal pain with haematemesis and fever (40 °C). Owing to persistent fever, three blood cultures were performed, all positive for Kocuria kristinae. The identification was based on biochemical tests and automated systems. The speciation of the micro-organism was achieved with MALDI-TOF and then confir...
Source: Journal of Medical Microbiology - May 23, 2013 Category: Microbiology Authors: Citro R, Prota C, Greco L, Mirra M, Masullo A, Silverio A, Bossone E, Piscione F Tags: J Med Microbiol Source Type: research
Effects of buprenorphine and meloxicam analgesia on induced cerebral ischemia in C57BL/6 male mice.
Abstract Laboratory mice constitute an extensively used model to study the pathologic and functional outcomes of cerebral ischemic stroke. The middle cerebral artery occlusion (MCAO) model requires surgical intervention, which potentially can result in postsurgical pain and stress. In the present study, we investigated whether buprenorphine and meloxicam, at clinically relevant doses provided pain relief without altering infarct volume in male C57BL/6 mice. Common known side-effects of buprenorphine, including decreased food consumption, were noted after surgery in buprenorphine-treated mice, but these effects were...
Source: Comparative Medicine - May 23, 2013 Category: Zoology Authors: Jacobsen KR, Fauerby N, Raida Z, Kalliokoski O, Hau J, Johansen FF, Abelson KS Tags: Comp Med Source Type: research
Deal with your chronic pain
Chronic pain conditions now affect more than 116 million Americans, according to the Institute of Medicine, a figure that dwarfs the number of people who suffer from diabetes, coronary heart disease/stroke and cancer combined. (Source: CNN.com - Health)
Source: CNN.com - Health - May 23, 2013 Category: Consumer Health News Source Type: news
Nationwide Study Maps Atherosclerotic Disease Heredity
Researchers at Lund University in Sweden have mapped the significance of heredity for common forms of atherosclerotic disease. No studies have previously examined whether different forms of the disease share heredity. The study looked at coronary heart disease, ischemic stroke, peripheral arterial disease and atherosclerosis of the aorta in individuals whose siblings and parents have suffered different types of cardiovascular disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 23, 2013 Category: Consumer Health News Tags: Heart Disease Source Type: news
Cost of Treating Strokes in U.S. Could Soar to $180B Annually by 2030: Report
Title: Cost of Treating Strokes in U.S. Could Soar to $180B Annually by 2030: ReportCategory: Health NewsCreated: 5/22/2013 12:35:00 PMLast Editorial Review: 5/23/2013 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - May 23, 2013 Category: Cardiology Source Type: news
Regenerating spinal cord fibers may be treatment for stroke-related disabilities
(Henry Ford Health System) A study by researchers at Henry Ford Hospital found "substantial evidence" that a regenerative process involving damaged nerve fibers in the spinal cord could hold the key to better functional recovery by most stroke victims. The findings may offer new hope to those who suffer stroke, the leading cause of long-term disability in adults. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 23, 2013 Category: Global & Universal Source Type: news
PPARα is involved in the multitargeted effects of a pretreatment with atorvastatin in experimental stroke
Abstract There is now substantial data in the literature showing that statins can protect against cerebral ischemia. This neuroprotective potency is related to their pleiotropic effects that modulate various pathways implicated in the pathophysiology of stroke. It has been demonstrated that statins exert anti‐inflammatory and vasculoprotective effects, thus contributing to a reduction in infarct size. The underlying mechanisms are still incompletely known. As a cross‐talk between statins and the nuclear receptor PPARα has been described, we hypothesized that this cross‐talk is necessary to neuroprotection in stroke....
Source: Fundamental and Clinical Pharmacology - May 23, 2013 Category: Drugs & Pharmacology Authors: Thavarak Ouk, Camille Potey, Maud Laprais, Sophie Gautier, Rémi Hanf, Raphaël Darteil, Bart Staels, Patrick Duriez, Régis Bordet Tags: Original Article Source Type: research
Prognostic value of plasma neuroendocrine biomarkers in patients with acute ischemic stroke
ConclusionsThese results suggest that a biomarker panel may add valuable and time‐sensitive prognostic information in the early evaluation of acute ischemic stroke. This may provide a channel for interventional therapy in acute stroke.This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - May 23, 2013 Category: Endocrinology Authors: Wen‐Jun Tu, Xiang Dong, Sheng‐Jie Zhao, De‐Gang Yang, Hui Chen Tags: Original Article Source Type: research
Pipeline for Uncoilable or Failed Aneurysms: Results from a Multicenter Clinical Trial [Neuroradiology]
Conclusion: PED offers a reasonably safe and effective treatment of large or giant intracranial internal carotid artery aneurysms, demonstrated by high rates of complete aneurysm occlusion and low rates of adverse neurologic events; even in aneurysms failing previous alternative treatments. © RSNA, 2013 (Source: Radiology)
Source: Radiology - May 23, 2013 Category: Radiology Authors: Becske, T., Kallmes, D. F., Saatci, I., McDougall, C. G., Szikora, I., Lanzino, G., Moran, C. J., Woo, H. H., Lopes, D. K., Berez, A. L., Cher, D. J., Siddiqui, A. H., Levy, E. I., Albuquerque, F. C., Fiorella, D. J., Berentei, Z., Marosfoi, M., Cekirge, Tags: Neuroradiology, Head and Neck Source Type: research
5 ways to handle chronic pain
Chronic pain conditions now affect more than 116 million Americans, according to the Institute of Medicine, a figure that dwarfs the number of people who suffer from diabetes, coronary heart disease/stroke and cancer combined. (Source: WDSU.com - Health)
Source: WDSU.com - Health - May 22, 2013 Category: Consumer Health News Source Type: news