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ALLHAT investigators report 10-year follow-up and stand by diuretics as first step antihypertensive treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New 10-year mortality and morbidity data confirm the original trial conclusions, they say, that while amlodipine and lisinopril are not superior to chlorthalidone on any outcome, chlorthalidone is superior to these agents on one or more secondary end points. Full agreement with this conclusion in the community, though, is still hard to come by. (Source: theHeart.org)
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info

Oral anticoagulants REDEEMed? Daily dabigatran "safe" with dual antiplatelets after MIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A dose-finding study saw what were characterized as low bleeding rates associated with triple-drug antithrombotic therapy that included the oral anticoagulant dabigatran in patients with a recent ACS event and other cardiovascular risk factors. (Source: theHeart.org)
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info

EFFECT: Public reporting of hospital performance improves quality of care?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Publicly released report cards based on hospital performance did not result in a measurably greater systemwide improvement in two composite AMI or CHF process-of-care indicators in a Canadian study. But they did appear to stimulate some important changes in delivery of care that could have led to some better outcomes. (Source: theHeart.org)
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info

BARI 2D cost-effectiveness analysis favors medication over PCI for less severe CVD in diabetic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New data from the BARI 2D trial comparing medical therapy vs revascularization in diabetics shows higher up-front costs of revascularization are only partially offset by long-term savings. (Source: theHeart.org)
Source: theHeart.org - November 18, 2009 Category: Cardiology Source Type: info

Ticagrelor effects unraveled in new phase 2 trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New and unique phase 2 data add to the growing body of evidence explaining the pharmacologic effects of the new antiplatelet agent ticagrelor. (Source: theHeart.org)
Source: theHeart.org - November 18, 2009 Category: Cardiology Source Type: info

CT-STAT: CT angiography rules out CAD faster and cheaper than standard careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of coronary CT angiography in the emergency room can successfully triage at-risk chest-pain patients and can do so faster and less expensively than standard diagnostic testing. (Source: theHeart.org)
Source: theHeart.org - November 18, 2009 Category: Cardiology Source Type: info

Baseline function data from STICH no help in pinpointing patients who benefit from SVREmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Measures of left ventricular dysfunction or wall motion identified by different imaging modalities at baseline offer no clues as to whether a subset of patients treated with surgical ventricular reconstruction might benefit from the procedure. (Source: theHeart.org)
Source: theHeart.org - November 18, 2009 Category: Cardiology Source Type: info

Niacin not beneficial in patients at goal with statins: NIA PlaqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The addition of niacin to statin therapy in secondary-prevention patients resulted in a significant improvement in lipids but failed to significantly alter atherosclerotic disease progression as measured by MRI. Researchers say it's a win for treating patients to target and suggest this trumps raising HDL. (Source: theHeart.org)
Source: theHeart.org - November 18, 2009 Category: Cardiology Source Type: info

JCHF: Are low doses of carvedilol effective in heart failure?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Doses of carvedilol as low as 2.5 mg daily may be effective in Japanese patients with heart failure, according to this study. But experts said the trial was far too small to draw any meaningful conclusions. (Source: theHeart.org)
Source: theHeart.org - November 18, 2009 Category: Cardiology Source Type: info

ACC/AHA focused update of guidelines for STEMI, PCIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The latest evidence for the treatment of STEMI and PCI has been incorporated into a fast-track update of US guidelines. But questions remain about the quality of some of the evidence informing the guidelines and about the composition of the writing committees. (Source: theHeart.org)
Source: theHeart.org - November 18, 2009 Category: Cardiology Source Type: info

CDC data show LDL screening rate remains stagnant; many who could benefit go without lipid-lowering drugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Editorialists discuss simplifying LD-management guidelines in light of a CDC study in which two-thirds of subjects who are at high risk for developing coronary disease within 10 years and eligible for lipid-lowering drugs were not on the medication. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

RE-LY: Post hoc analysis confirms benefit of dabigatran relative to warfarin at all INR levelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new analysis confirms that regardless of INR control achieved across participating centers, dabigatran remained noninferior at the lower dose and superior at the higher dose to warfarin for prevention of stroke and systemic embolism. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

Cardiologists shocked by new FDA alert on clopidogrel-PPI interactionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The FDA has issued a new warning on an interaction between clopidogrel and the PPI omeprazole and other drugs that inhibit the CYP2C19 enzyme, just weeks after the only randomized trial on this issue reported no such interaction. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

Statins do not eliminate risk of low HDL-cholesterol levelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers say a new study shows that statins don't alter the risks associated with low HDL-cholesterol levels and that raising HDL cholesterol 10 mg/dL could prevent an additional eight MIs per 1000 patient-years. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

Kenneth Baughman killed while jogging at AHAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr Kenneth Baughman, a cardiologist at Brigham and Women's Hospital, died Monday morning in Orlando, FL, when he was struck by a car while out for a morning run. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

Anthracycline cardiotoxicity appears limited in breast cancer in the short termEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No significant incidence of short-term cardiac toxicity was observed in breast-cancer patients on dose-dense anthracycline regimens, but longer-term follow-up is needed. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

POPE: No benefit of diclofenac on pericardial effusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mean pericardial effusion grade postcardiac surgery was not reduced with 14 days of treatment with the NSAID. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

CASCADE: No significant benefit of clopidogrel in reducing graft disease after CABGEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dual antiplatelet therapy did not significantly reduce vein graft intimal hyperplasia compared with aspirin alone over 12 months. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

HEAAL: High-dose trumps low-dose ARB for heart failure in the ACE-inhibitor intolerantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The randomized trial, which compared losartan dosages of 150 mg/day and 50 mg/day, "makes a strong case for the value of incremental inhibition of the renin-angiotensin system," its authors say. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

HeartMate II continuous-flow VAD sets new benchmark in destination-therapy trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thoratec's HeartMate II continuous-flow VAD keeps about half of patients alive and stroke- or reintervention-free after two years in pivotal destination therapy trial. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

FAIR-HF: Symptom improvement, functional gains follow correction of iron deficiency in heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The randomized, placebo-controlled study's intriguing wrinkle: the benefits after 24 weeks of treatment with an injectable form of iron were independent of whether the patients were anemic. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

Bypassing the blues: How simple collaborative care can help tackle depression after CABG surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Depression after coronary artery bypass surgery is often overlooked by physicians but is associated with worse outcomes. A new US study illustrates a simple telephone-based approach to tackle this, with nurses encouraging patients to seek help from their primary-care doctors and providing ongoing feedback and review. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

Postop anemia in high-CV-risk patients: No CV gains from fixed hemoglobin target in trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A randomized trial found no protection from in-hospital cardiovascular events with a strategy of blood transfusions to maintain hemoglobin above 10 g/dL, compared with a more conservative approach to transfusion therapy, in patients with CV disease or risk factors who underwent hip surgery. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

RECORD AF: Better success with rhythm control, but no difference in outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New registry data presented this week showed that cardiologists are more likely to select rhythm control over rate control for the treatment of atrial fibrillation, and this strategy is more likely to lead to successful treatment of AF than the rate-control-based approach. Both strategies are equivalent in terms of their effect on clinical outcomes. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

Massachusetts data show similar STEMI PCI outcomes in hospitals with or without surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Data from a Massachusetts registry add to the growing evidence that hospitals without bypass-surgery capabilities can match the acute coronary intervention outcomes of surgery-on-site centers. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

Cangrelor in CHAMPION: What went wrong?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion is abounding on why cangrelor did not show benefit over clopidogrel despite the fact that it did inhibit platelet activity more effectively. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

Plasma renin activity associated with cardiovascular events and mortality in HOPEEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with elevated baseline plasma renin activity levels had a twofold increased risk of total or cardiovascular mortality compared with those with low levels, and the strength of the association persisted after multiple adjustments, including the HOPE score, CRP, and BNP. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

Medical device correction issued for Cardiac Science AEDsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AEDs manufactured by Cardiac Science are undergoing a nationwide voluntary medical device correction because of the potential failure of these devices to deliver therapy during use. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

REPLACE registry finds 15.3% six-month complication rate with pacer and ICD lead replacementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The REPLACE registry finds "sobering" comprehensive risk rates with pacemaker and ICD upgrades. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

PRINCE: Prehospital intranasal cooling after cardiac arrest feasible, may improve survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A device that allows therapeutic hypothermia to begin in the field has been shown to be safe and its use feasible in treating out-of-hospital cardiac arrest. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

Experienced operators can switch easily and rapidly to radial access PCI: RAPTOREmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Experienced interventional cardiologists can rapidly shift their practice from the femoral-artery to the radial-access approach, with no increase in procedure time and radiation exposure for PCI. Also, the transradial approach leads to a more economic use of hospital resources, say researchers. (Source: theHeart.org)
Source: theHeart.org - November 15, 2009 Category: Cardiology Source Type: info

CHAMPION: Negative trials but some positive angles for cangrelor?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although neither CHAMPION-PCI nor CHAMPION-PLATFORM showed significant reductions in the primary end point with this new IV antiplatelet agent, some positive effects were seen, suggesting that the drug may yet have a future. (Source: theHeart.org)
Source: theHeart.org - November 15, 2009 Category: Cardiology Source Type: info

ASTRAL finds no benefit of revascularization over medical therapy alone for renal-artery stenosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Percutaneous revascularization of atherosclerotic renal arteries improves patency, but its benefits on renal function have been evaluated only in small studies. The 806-patient ASTRAL trial found no evidence of benefit from revascularization. (Source: theHeart.org)
Source: theHeart.org - November 11, 2009 Category: Cardiology Source Type: info

FDA investigating external-defib energy levelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The agency is following up on 14 reports over the past three years of unsuccessful defibrillation/cardioversion attempts from a 200-J device followed by successful therapy from a 360-J unit. (Source: theHeart.org)
Source: theHeart.org - November 11, 2009 Category: Cardiology Source Type: info

Regions with high rates of carotid-stenting adoption have poorer outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a new study suggest that, as the use of carotid artery stenting has become more widespread following expanded Medicare coverage, overall revascularization outcomes have worsened. (Source: theHeart.org)
Source: theHeart.org - November 11, 2009 Category: Cardiology Source Type: info

What's going to be hot at AHA 2009?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anticipation is building for full trial results from ARBITER 6-HALTS, plus a better understanding of what went wrong with cangrelor in the CHAMPION trials. Also in the lineup are updates from PLATO, RE-LY, ALLHAT, BARI 2D, STICH, CASCADE, POPULAR, HEARTMATE II, and many more. Indeed, this year's "late-breaking" sessions include more than 30 trials over five days. (Source: theHeart.org)
Source: theHeart.org - November 11, 2009 Category: Cardiology Source Type: info

Walking speed predicts CV mortality in older peopleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fast walkers should find themselves less likely to succumb to cardiovascular death, according to a new French study in older adults. Measuring general fitness in this way could easily be incorporated into a general global assessment of cardiovascular risk, say the researchers. (Source: theHeart.org)
Source: theHeart.org - November 11, 2009 Category: Cardiology Source Type: info

No benefits of aspirin for primary prevention in diabetics, meta-analysis suggestsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Most guideline documents recommend aspirin for primary prevention in people with diabetes, but a new meta-analysis has found no benefit of the widely used drug across a range of different cardiovascular end points. The results speak to the need for dedicated randomized trials, investigators say. (Source: theHeart.org)
Source: theHeart.org - November 10, 2009 Category: Cardiology Source Type: info

Clopidogrel effects in men vs womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new meta-analysis has suggested that clopidogrel reduces cardiovascular events and increases bleeding in both men and women, without significant differences between the sexes. (Source: theHeart.org)
Source: theHeart.org - November 10, 2009 Category: Cardiology Source Type: info

One in four discharged after heart-failure hospitalization are back within a monthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
What's behind the high rehospitalization rate, the same one seen year after year, for patients discharged after a hospitalization for heart failure, in an analysis covering three years of Medicare data? The authors propose one reason. (Source: theHeart.org)
Source: theHeart.org - November 10, 2009 Category: Cardiology Source Type: info

Class I recall of CardioVations EndoClamp cathetersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Edwards's September 24 recall of balloon catheters used in bypass surgery has been categorized as a class I recall by the FDA. (Source: theHeart.org)
Source: theHeart.org - November 10, 2009 Category: Cardiology Source Type: info

Echocardiographic evidence of PAH often doesn't trigger referral to a specialistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Only one in four patients with echocardiographic evidence of pulmonary arterial hypertension is being referred for further evaluation. (Source: theHeart.org)
Source: theHeart.org - November 10, 2009 Category: Cardiology Source Type: info

Interventional cardiologist Donald Baim diesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interventional cardiologist, Dr Donald Baim, chief medical and scientific officer at Boston Scientific, has died. (Source: theHeart.org)
Source: theHeart.org - November 6, 2009 Category: Cardiology Source Type: info

Latest European and US STEMI guidelines compared and contrastedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The latest recommendations for the treatment of ST-elevation MI issued by American cardiology associations and the European Society of Cardiology are compared and contrasted in a new paper. (Source: theHeart.org)
Source: theHeart.org - November 6, 2009 Category: Cardiology Source Type: info

Enrollment halts in randomized trial of CPR for out-of-hospital arrestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No survival differences after out-of-hospital cardiac arrest were seen at a preliminary DSMB review in the ROC PRIMED trial, which compared early vs delayed post-CPR assessment for defibrillation and tested the effectiveness of a device for optimizing intrathoracic pressure during CPR. (Source: theHeart.org)
Source: theHeart.org - November 6, 2009 Category: Cardiology Source Type: info

Medicaid access to smoking cessation falls shortEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A national survey shows that although the majority of state Medicaid programs offer coverage for some form of tobacco-dependence treatment, most fall far short of a stated mandate to provide unrestricted access to approved therapies. (Source: theHeart.org)
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info

Serum phosphorous, kidney function predict CACEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Spokane Heart Study finds a connection between kidney function, serum phosphorus, and the risk of coronary artery calcification. (Source: theHeart.org)
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info

Low-cholesterol/cancer studies should "dispel lingering doubts" of causal linkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two new papers should help put to rest concerns that low serum cholesterol levels may increase cancer risk. (Source: theHeart.org)
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info

Not all metabolic syndrome is created equal: Framingham Offspring analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The syndrome (defined by ATP III criteria) can predict increased cardiovascular and mortality risk or not, depending on which three of five risk factors contributed to the diagnosis, a cohort study suggests; its investigators caution that their observations are only preliminary. (Source: theHeart.org)
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info

Prehospital triage "immediately successful" in boosting rates of thrombolytic therapy for strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Toronto researchers report that a citywide prehospital protocol raised their rates of thrombolytic treatment to among the highest in North America, underlining, they say, the critical importance of organized stroke care. (Source: theHeart.org)
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info