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Impact of glycogen synthase kinase-3 ß inhibition on rats' temporomandibular joint collagen-induced rheumatoid arthritis with correlation to miRNA-155/miRNA-24 expression
CONCLUSIONS: Our results reveal for the first-time correlation of miRNA-155 and miRNA-24 that might be implicated in the onset of TMJ RA. Consequently, the treatment of CIA with GSK inhibitor (TDZD-8) yields encouraging results. We predicted the TDZD-8 might protect against CIA by suppressing miRNA-155, miRNA-24, and S100A4 protein levels.PMID:37667918 | DOI:10.26355/eurrev_202308_33393
Source: European Review for Medical and Pharmacological Sciences - September 5, 2023 Category: Drugs & Pharmacology Authors: R H Al-Serwi G Othman A F Dawood A K Alhumaidan H S Alharbi M El-Sherbiny M E Almadani D M A Elsherbini Source Type: research

Three-dimensional analysis of the morphological changes of the craniofacial jaw and condyle in patients with idiopathic condylar resorption
This study aims to describe three-dimensional analysis on condylar deformation of temporomandibular joint (TMJ) and morphological changes of craniofacial jaw in patient with idiopathic condylar resorption (ICR) and to compare those with healthy, age and gender matched control group. Cone-Beam Computed Tomography (CBCT) and cephalometric X-ray were conducted and analysis of craniofacial measurement, condylar width, length, and height as well as condylar axial angle changes were done three-dimensionally using Proplan CMF 3.0 software.
Source: The British Journal of Oral and Maxillofacial Surgery - September 4, 2023 Category: ENT & OMF Authors: Aung Phyo Thu, Shao Hua Song, Niluja Karmacharya, Xuanping Huang, Nuo Zhou Source Type: research

Surgical Treatment of Condylar Hyperplasia: One-Stage vs Two-Stage Surgery
Condylar hyperplasia (CH) is a pathologic overgrowth of the mandibular condyle and can be unilateral or bilateral. Due to the limited etiological understanding of CH and limited medical options, treatment of CH is surgical. Treatment of CH depends on whether the disease is active or not. If condylar hyperplasia is still active, surgical removal of the hyperplastic condyle (high condylectomy) and orthognathic surgery to correct the bite are indicated. Orthognathic surgery without condylar surgery is not biologically stable and has a high relapse rate.
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Matthew L. Beck, Luis Eduardo Almeida, Flavio A. Camejo Tags: TMJ Source Type: research

Intraobserver reliability and validity of a single ultrasonic measurement of the lateral condyle-capsule distance in the temporomandibular joint
ConclusionIntraobserver reliability of a trained examiner is very high in the single measurement of the LCCD and validity is significant compared to more complex methods. The risk of bias is low since the mean of three LCCD measurements is calculated as opposed to recording only one single measurement.
Source: Journal of Ultrasound - September 1, 2023 Category: Radiology Source Type: research

Metal Allergy Testing in Patients Listed for Temporomandibular Joint Replacement at Massachusetts General Hospital
Patients with temporomandibular joint (TMJ) arthropathies (i.e end-stage degeneration, invasive pathology, or developmental anomalies) may be candidates for total joint replacement (TJR). There is only one FDA-approved manufacturer of patient-specific alloplasts of the TMJ, Stryker-TMJ Concepts. Stryker can fabricate a custom prosthesis composed of a cobalt-chromium-molybdenum alloy, with a maximum of 1% nickel present in the condylar component. However, metal hypersensitivity can occur, which may cause failure in up to 3% of TMJ replacements.
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Hadley Johnson, Briana Burris, Joseph McCain, JiaDe Yu Source Type: research

Reconstruction of the temporomandibular joint using a vascularized medial femoral condyle osteocartilaginous flap: an experimental investigation in miniature pigs
Reconstruction of the temporomandibular joint (TMJ) is a significant challenge in maxillofacial surgery. A vascularized medial femoral condyle (MFC) osteocartilaginous flap is a good choice for TMJ reconstruct...
Source: BMC Oral Health - September 1, 2023 Category: Dentistry Authors: Tianyi Lin, Shuo Chen, Long Xia, Bimeng Jie, Yi Zhang and Yang He Tags: Research Source Type: research

Outcomes of Double-Suture Arthroscopic Discopexy Part 1: Technique, a Review of 79 Postoperative MRIs and a Protocol for Their Interpretation
There are several published descriptions of techniques for TMJ discopexy using both open and arthroscopic approaches. Notably, McCain1 and Yang2 have published on the clinical outcomes of arthroscopic discopexy, with Yang including postoperative MRIs to demonstrate the stability of this treatment modality. Despite this, there are controversies in the literature regarding the clinical and radiographic outcomes of discopexy and its indications. The purpose of this study is to present a modification of the discopexy technique initially described by McCain,1 along with postoperative MRIs as the first large sample study from the United States.
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Christopher K.B. Ward, Mohamed Hakim Source Type: research

Correlation of Arthroscopic Findings with Time to Lock in the Temporomandibular Joint
The course of temporomandibular joint (TMJ) degeneration following onset of symptoms is incompletely understood. Many patients have no symptoms despite having disc dislocations confirmed by magnetic resonance imaging (MRI). However, there may be a component of inflammation and synovitis that can precipitate over time and lead to worsening symptoms and prognosis for the patient.1 Through previous longitudinal studies,2 there is a clear understanding that a certain percentage of patients may go on to develop deformity of the disc, remodeling of the condyle, and perforations of the disc.
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Sheridan Danquah, Fernando P.S. Guastaldi, Briana J. Burris, Daniel D. Choi Source Type: research

Utilization of Endoscopic and Exoscopic Assistance During Excision of Temporomandibular Joint Pathologies With Skull Base Extension: Review of Seven Cases from Massachusetts General Hospital
Historically, despite complex regional anatomy surrounding the temporomandibular joint (TMJ) and the potential for associated intracranial defects, open arthroplasties to treat pathologic lesions of the TMJ were performed without the use of a microscope. There is increasing popularity of use of endoscopic-assistance to provide a magnified illuminated-view of TMJ structures, access surgical blind-spots, and document findings. Emerging technology of extracorporeal video-telescopes (exoscopes) have shown efficacious applications for surgeons in neurosurgery, otolaryngology, and microvascular surgery.
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Briana J. Burris, Daniel D. Choi, Joseph P. McCain Source Type: research

Effect of Arthrocentesis on Temporomandibular Joint Osteoarthritis Patients
Arthrocentesis is an effective treatment method for patients with sudden and severe closed lock. Insertion of needles into the superior joint space of the temporomandibular joint (TMJ) under local anesthesia is possible. Patients can benefit from pain reduction and immediate increasing of jaw mobility. Arthrocentesis has been considered to be a noninvasive surgical option before surgical intervention to treat TMJ internal derangement not improved by conservative non-surgical therapies. The mechanisms of arthrocentesis are: 1) Removing adhesions between the disc surface and the mandibular fossa, 2) Cleaning inflammation- an...
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Chaeyeon Lee, Taeyeong Kim, Yuha Jung, Jong-Ki Huh, Jae-Young Kim Source Type: research

Normative 3D Mandibular and TMJ Kinematics in Orthognathic Asymptomatic and Symptomatic Patients
Temporomandibular disorders (TMD) are widely prevalent1 with patients often experiencing limited temporomandibular joint (TMJ) function and motion, affecting critical activities of daily living. TMJ symptoms, such as joint sounds and mild pain, are often found in patients with dentofacial deformities. However, skeletal malocclusion classification (Class II, III) and sex and their effects on TMJ function necessitates clarification.2 Additionally, orthognathic surgery can alleviate these symptoms, but the biomechanics are unknown.
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Cherice Hill, Shuchun Sun, Angela Mei, Konstantinia Almpani, Priyam Jani, Farhad Ahmadi, Brooke Damon, Elizabeth Slate, Hai Yao, Janice S. Lee Source Type: research

TMJ Symptoms Resolve With Orthognathic Surgery and Are Associated With Condylar Remodeling
Prevalence of temporomandibular disorders in patients with dentofacial deformities may be as high as 64.29%.1 Orthognathic surgery can result in a decrease in temporomandibular joint (TMJ) symptoms as a secondary benefit of surgery, and the mechanism by which this occurs is currently unknown.2 The aim of this study is to determine if improvement of TMJ symptoms after orthognathic surgery is associated with 3-dimensional condylar morphology changes and remodeling. Patients enrolled in an IRB-approved prospective natural history study on morphological differences across dentofacial deformities at the NIH between 2018 and 2022.
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Sarah Lynn, Priyam Jani, Konstantinia Almpani, Hai Yao, Olivier Duverger, Janice S. Lee Tags: Orthognathic and TMJ Track: Hot-off-the-Press and Abstract Session Source Type: research

Retrospective Analysis of Heterotopic Ossification in Zimmer-Biomet and TMJ Concepts
This is a retrospective cohort study to review all the cases in which patients have undergone alloplastic TMJ reconstruction from 2011 to 2021 at the Hospital of University of Pennsylvania. The primary objective is to determine the heterotopic ossification incidence between 2 competing FDA-approved alloplastic implants (Zimmer-Biomet © and TMJ Concepts©), and secondary endpoint to perform statistical analysis to identify the risk factors of heterotopic ossification.
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Alexander Y. Li, Brendan Wu, Kevin Francois, Blaine Radley, Peter D. Quinn, Eric J. Granquist, Helen Giannakopoulos Source Type: research

Is the Temporomandibular Joint Direct Joint Loading Test Associated with Arthroscopic and Histologic Findings?
Temporomandibular joint disorders (TMD) have been estimated to affect between 12-31% of adults worldwide, with a higher prevalence in women.1, 2 The direct joint loading test is 1 component of the clinical exam, often performed in attempt to distinguish intra-articular disorders from extra-articular disorders. Although the direct joint loading test is advocated for by TMJ experts, the exam remains unvalidated and is not included in the diagnostic criteria for TMD.2-4 The aim of this study was to assess the prevalence of positive preoperative direct joint loading tests and report the associated: diagnostic imaging, arthrosc...
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Lindsay Pius, Briana J. Burris, Joseph P. McCain Source Type: research

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