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Total 19484 results found since Jan 2013.
Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy
CONCLUSIONS: Besides the development of an epiretinal membrane in one patient, the intravitreal application of allogeneic BM-MSCs appeared to be intraocularly well tolerated. Consequently, not only NA-AION but also BM-MSCs deserve more clinical investigational resources and a larger randomized multicenter trial that would provide stronger evidence both about safety and the potential therapeutic efficacy of intravitreally injected allogeneic BM-MSCs in acute NA-AION.TRIAL REGISTRATION: Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NEUROSTEM). NCT03173638...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jose C Pastor Salvador Pastor-Idoate Marina L ópez-Paniagua Marta Para Francisco Blazquez Esther Murgui Ver ónica García Rosa M Coco-Mart ín Source Type: research
Hyperbaric oxygen therapy suppresses hypoxia and reoxygenation injury to retinal pigment epithelial cells through activating peroxisome proliferator activator receptor-alpha signalling
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17963. Online ahead of print.ABSTRACTRetinal ischemia followed by reperfusion (IR) is a common cause of many ocular disorders, such as age-related macular degeneration (AMD), which leads to blindness in the elderly population, and proper therapies remain unavailable. Retinal pigment epithelial (RPE) cell death is a hallmark of AMD. Hyperbaric oxygen (HBO) therapy can improve IR tissue survival by inducing ischemic preconditioning responses. We conducted an in vitro study to examine the effects of HBO preconditioning on oxygen-glucose deprivation (OGD)-induced IR-injured RPE ce...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Tzong-Bor Sun Kuo-Feng Huang Ko-Chi Niu Cheng-Hsien Lin Wen-Pin Liu Chao-Hung Yeh Shu-Chun Kuo Ching-Ping Chang Source Type: research
Nationwide trends in emergency department utilisation for acute retinal ischaemia in the USA, 2011-2018
Conclusion
Of the estimated 48 000 patients with TMVL or RAO annually in the USA, few are evaluated in the ED, and admission rates are less than for transient ischaemic attack or ischaemic stroke and are decreasing over time.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Hamedani, A. G., De Lott, L. B., Willis, A. W. Tags: Original articles - Clinical science Source Type: research
Serum retinol-binding protein 4 in stroke patients: correlation with T helper 17/regulatory T cell imbalance and 3-year cognitive function decline
ConclusionSerum RBP4 is positively associated with a Th17/Treg cell imbalance and, more importantly, it is indicative of cognitive function decline within 3 years in stroke patients. Thus, early and timely interventions and physical rehabilitation are more necessary in stroke patients with high serum RBP4.
Source: Frontiers in Neurology - September 21, 2023 Category: Neurology Source Type: research
Central retinal vein and artery occlusion associated with sildenafil: a case report and review of the literature
ConclusionSildenafil may be associated with severe retinal vascular accidents in otherwise healthy young individuals.
Source: Journal of Medical Case Reports - September 20, 2023 Category: General Medicine Source Type: research
Cilioretinal artery occlusion secondary to central retinal vein occlusion
Can J Ophthalmol. 2023 Sep 16:S0008-4182(23)00271-5. doi: 10.1016/j.jcjo.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37726095 | DOI:10.1016/j.jcjo.2023.08.010
Source: Canadian Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Heather M McDonald Armin Handzic Edward Margolin Source Type: research
A novel primary porcine retinal pigment epithelium cell model with preserved properties
CONCLUSIONS: This work describes, for the first time, a pRPE cell model that exhibits preserved RPE properties for several passages on cell culture plastic plates. Though RPE characteristics were maintained for at least 6 passages, the reduced CRALBP and RPE-65 with passaging emphasize that lower passage cells are advantageous to utilise, and that morphology, barrier function and ZO-1 localisation cannot be solely employed as a quality measure of RPE identity. Pigs are phylogenetically similar to humans, including similar physiology, anatomy and immune system. Therefore, porcine RPE cells constitute a relevant model system...
Source: Current Eye Research - September 19, 2023 Category: Opthalmology Authors: Dinna Zhou Anne Petersen Julia Adel öf Malin Hernebring Madeleine Zetterberg Source Type: research
Optical coherence tomography angiography in birdshot chorioretinopathy
CONCLUSION: Our study demonstrates the potential contribution of OCTA as a new non-invasive imaging technology that monitors disease activity in BSCR patients.PMID:37723901 | DOI:10.1177/11206721231203265
Source: European Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Francesco Pichi Andrea Lembo Paolo Nucci Piergiorgio Neri Source Type: research
Cilioretinal artery occlusion secondary to central retinal vein occlusion
Can J Ophthalmol. 2023 Sep 16:S0008-4182(23)00271-5. doi: 10.1016/j.jcjo.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37726095 | DOI:10.1016/j.jcjo.2023.08.010
Source: Canadian Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Heather M McDonald Armin Handzic Edward Margolin Source Type: research
Optical coherence tomography angiography in birdshot chorioretinopathy
CONCLUSION: Our study demonstrates the potential contribution of OCTA as a new non-invasive imaging technology that monitors disease activity in BSCR patients.PMID:37723901 | DOI:10.1177/11206721231203265
Source: European Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Francesco Pichi Andrea Lembo Paolo Nucci Piergiorgio Neri Source Type: research
A novel primary porcine retinal pigment epithelium cell model with preserved properties
CONCLUSIONS: This work describes, for the first time, a pRPE cell model that exhibits preserved RPE properties for several passages on cell culture plastic plates. Though RPE characteristics were maintained for at least 6 passages, the reduced CRALBP and RPE-65 with passaging emphasize that lower passage cells are advantageous to utilise, and that morphology, barrier function and ZO-1 localisation cannot be solely employed as a quality measure of RPE identity. Pigs are phylogenetically similar to humans, including similar physiology, anatomy and immune system. Therefore, porcine RPE cells constitute a relevant model system...
Source: Current Eye Research - September 19, 2023 Category: Opthalmology Authors: Dinna Zhou Anne Petersen Julia Adel öf Malin Hernebring Madeleine Zetterberg Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Efficacy and safety of hyperbaric oxygen therapy monitored by fluorescein angiography in patients with retinal artery occlusion
CONCLUSION: In RAO patients monitored by FA until spontaneous revascularisation of the central retinal artery, HBOT was effective and safe.PMID:37722767 | DOI:10.1136/bjo-2023-323972
Source: The British Journal of Ophthalmology - September 18, 2023 Category: Opthalmology Authors: Jeremy Chiabo Andreas Kauert Barbara Casolla Julie Contenti Sacha Nahon-Esteve Stephanie Baillif Martel Arnaud Source Type: research
