Vaccines
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What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens?
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The route of vaccination is important in influencing immune responses at the initial site of pathogen invasion where protection is most effective. Immune responses required for mucosal protection can differ vastly depending on the individual pathogen. For some mucosal pathogens, including acute self-limiting infections, high-titer neutralizing Abs that enter tissue parenchyma or transude into the mucosal lumen are sufficient for clearing cell-free virus. However, for pathogens causing chronic infections such as HIV, hepatitis C virus, herpes viruses, mycobacteria, and fungal and parasitic infections, a single arm of th...
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Belyakov IM, Ahlers JD Tags: J Immunol Source Type: journals
Swine flu vaccination extended to all children under fiveEmail this article to a colleague.
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NHS figures show children under 16 are most likely to be admitted to hospital with swine flu, and 21% of deaths in England are among under-14s (Source: Management in Practice)
Source: Management in Practice - November 20, 2009 Category: Practice Management Source Type: news
How HIV gives antibodies the slipEmail this article to a colleague.
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New structural studies may help vaccine designers hit HIV where it hurts (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - November 20, 2009 Category: Chemistry Source Type: journals
Anti-HIV Antibody ConstraintsEmail this article to a colleague.
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Despite significant efforts, an effective vaccine against the HIV-1 virus remains elusive. A site on the HIV-1 gp120 envelope glycoprotein that binds to the CD4 receptor on host cells is … [Read more] (Source: This Week in Science)
Source: This Week in Science - November 20, 2009 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: journals
Novavax to raise $21MEmail this article to a colleague.
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Novavax, moving closer to commercializing its flu vaccines, will raise $21 million in a secondary stock offering to fund continued research. (NVAX) (Source: bizjournals.com Health Care:Hospitals headlines)
Source: bizjournals.com Health Care:Hospitals headlines - November 20, 2009 Category: Hospital Management Source Type: journals
Free H1N1 Vaccine Walk-In Clinic for UK CommunityEmail this article to a colleague.
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The University Health Service (UHS) has 900 doses of H1N1 intranasal vaccine from the Lexington-Fayette County Health Department. The intranasal vaccine will be available to members of the University of Kentucky campus community who are 18 years of age or over (or with a UK student I.D.) during a free walk-in clinic from 8 a.m. to 12 p.m. Friday, Nov. 20 on the first floor of the UHS building, 830 S. Limestone. (Source: UK College of Medicine News)
Source: UK College of Medicine News - November 20, 2009 Category: Universities & Medical Training Tags: 7H000 clinical h1n1 vaccine Source Type: news
Immunization consensus for children and adolescents with rheumatic diseasesEmail this article to a colleague.
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The objective of this study was to establish an evidence-based consensus on the efficacy and safety of vaccination in children and adolescents with rheumatic diseases. Passive immunization of patients and guidelines for people who live with immunosuppressed patients were also included. The 32 pediatric rheumatologists of the Rheumatology Department of the Pediatrics Society of São Paulo, (SPSP, from the Portuguese), São Paulo, SP, Brazil, and/or the Commission on Pediatrics Rheumatology of the Brazilian Society of Rheumatology are responsible for this consensus; some of those professionals are involved on research and sc...
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals
Primary antiphospholipid syndrome and hepatitis B and C infectionsEmail this article to a colleague.
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CONCLUSION: A small percentage of patients with primary APS had positive serology for hepatitis B and C, and all represented cases post-vaccine or serology scar. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals
Educating the Public About H1N1Email this article to a colleague.
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A recent Associated Press–GfK poll () showed that a sizable percentage of parents, amounting to 38% of those surveyed, indicated that they would not permit their children to receive the H1N1 vaccination at school. Reasons offered by parents opposed or hesitant to allow their children to be vaccinated were fears associated with untoward side effects. Prominent among concerns was the fact that thimerosal, a mercury-based preservative is one of the ingredients of the injectable form of the vaccination; it is not in the FluMist spray (. (Source: Journal of Pediatric Nursing)
Source: Journal of Pediatric Nursing - November 20, 2009 Category: Nursing Authors: Cecily Betz Tags: Editorial Source Type: journals
Vaccination sees H1N1 cases fallEmail this article to a colleague.
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The rate of swine flu infection has fallen by around 9,000 cases in the last week, Department of Health figures report (Source: Nursing in Practice)
Source: Nursing in Practice - November 20, 2009 Category: Nursing Source Type: news
Media Myths Cloud Joint Hearings on Pandemic VaccineEmail this article to a colleague.
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The commentary discusses the impact of media myths on joint hearings on pandemic vaccine shortfalls. (11/19/09 17:17) (Source: Recombinomics)
Source: Recombinomics - November 20, 2009 Category: Infectious Diseases Source Type: info
The role of Toll-like receptor 4 in eliciting acquired immune responses against nontypeable Haemophilus influenzae following intranasal immunization with outer membrane proteinEmail this article to a colleague.
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Conclusions: TLR4 plays an important role in relation to Th1 function for optimal development of the acquired immune responses to OMP administered intranasally. The variety of immune responses via TLR4 expression needs to be taken into consideration of individual vaccinations to prevent AOM. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - November 20, 2009 Category: ENT & OMF Authors: Takashi Hirano, Satoru Kodama, Munehito Moriyama, Toshiaki Kawano, Masashi Suzuki Tags: Research papers Source Type: journals
4.8 million doses of H1N1 vaccine on wayEmail this article to a colleague.
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A total of 4.8 million doses of the H1N1 vaccine will be delivered to the provinces by Sunday, CBC News has learned. (Source: CBC | Health)
Source: CBC | Health - November 20, 2009 Category: Consumer Health News Source Type: news
Vaccination against the influenza virus and mortality due to cardiovascular diseases in the city of Sao PauloEmail this article to a colleague.
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CONCLUSION: The vaccination against the Influenza virus was associated with a significant decrease in the mortality due to IHD. (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - November 20, 2009 Category: Cardiology Source Type: journals
My family’s story: surviving swine fluEmail this article to a colleague.
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Thanks to H1N1, Halloween came on November 15 for the Lord and Ladies of the Cyr household
My wife, Sara, and I are the proud parents of newly minted 4-year-old triplets, and this fall we just haven’t been able to get healthy in our house. We get over one illness and another one crops up a week later. Fevers come and go. Coughs are incessant. Headaches bloom and recede. It’s been never-ending.
So none of us was feeling particularly well on the Thursday before Halloween when Sara called me at work and told me she had spiked a fever. We weren’t sure it was H1N1, but working in the Public Affairs Department here at Ch...
Source: Thrive, Children's Hospital Boston - November 20, 2009 Category: Pediatrics Authors: Matt Cyr Tags: H1N1 (swine flu) One parent's story Flu vaccine seasonal flu swine flu vaccine vaccines Source Type: organizations
Video: Teen's Rare H1N1 Vaccine Side EffectEmail this article to a colleague.
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A Va. Teen was diagnosed with a rare disease, Gillian Barre Syndrome, shortly after receiving the H1N1 vaccine. Dr. Jennifer Ashton reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 20, 2009 Category: Consumer Health News Source Type: news
Ont. health units seek ways to shorten flu shot linesEmail this article to a colleague.
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Public health officials across Ontario have put on their creative thinking caps and come up with some very high tech, innovative ways to try to shorten lineups for the H1N1 vaccine. (Source: CBC | Health)
Source: CBC | Health - November 20, 2009 Category: Consumer Health News Source Type: news
Potential Strategy To Help Generate HIV-Neutralizing AntibodiesEmail this article to a colleague.
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WHAT: New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: HIV / AIDS Source Type: news
Yale Researchers Target Tick Saliva In Their Search For Lyme DiseaseEmail this article to a colleague.
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A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites. Traditionally, vaccines have directly targeted specific pathogens. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
As cost of child vaccines fall, more kids are savedEmail this article to a colleague.
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Babies squirmed and wailed as needles plunged into their chubby thighs at a public health clinic on the outskirts of Hanoi on Friday. Like little ones everywhere, the reaction to the sting was never pretty. (Source: CTV Health)
Source: CTV Health - November 20, 2009 Category: Consumer Health News Source Type: news
Gripes About Swine Flu Vaccine AboundEmail this article to a colleague.
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When the nation's swine flu vaccination program began in early October, health officials predicted it was going to be "messy." They were right. (Source: WDSU.com - Health)
Source: WDSU.com - Health - November 20, 2009 Category: Consumer Health News Authors: WDSU.com Source Type: news
Batch of H1N1 vaccine recalled after bad reactionsEmail this article to a colleague.
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More than 100,000 doses of the H1N1 vaccine were withdrawn Thursday, due to a warning that one particular batch of the vaccine had a higher than usual amount of adverse reactions among patients. (Source: CTV Health)
Source: CTV Health - November 20, 2009 Category: Consumer Health News Source Type: news
Batch of H1N1 vaccine pulled after bad reactionsEmail this article to a colleague.
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More than 100,000 doses of the H1N1 vaccine were withdrawn Thursday, due to a warning that one particular batch of the vaccine had a higher than usual amount of adverse reactions among patients. (Source: CTV Health)
Source: CTV Health - November 20, 2009 Category: Consumer Health News Source Type: news
Vaccination of under-fives will create 'massive' workload, GPC warnsEmail this article to a colleague.
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The expansion of the swine flu vaccination programme to all children under five will create a 'massive workload' for GPs, the GPC has warned. (Source: HealthcareRepublic Independent Nurse News)
Source: HealthcareRepublic Independent Nurse News - November 20, 2009 Category: Nursing Source Type: news
Cost Of Child Vaccines Fall, More Kids SavedEmail this article to a colleague.
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Starting next year an extra 6.3 million children worldwide will have the chance to feel the pinch of a needle and get vaccinated against some of the world's deadliest illnesses, (Source: WDSU.com - Health)
Source: WDSU.com - Health - November 20, 2009 Category: Consumer Health News Authors: WDSU.com Source Type: news
Sri Lanka orders import of A/H1N1 vaccineEmail this article to a colleague.
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COLOMBO, Nov. 20 (Xinhua) -- Sri Lanka's health authorities ... (Source: Xinhuanet Chinaview Health)
Source: Xinhuanet Chinaview Health - November 20, 2009 Category: Consumer Health News Tags: Health Source Type: news
Swine flu vaccination programme extended to under-fivesEmail this article to a colleague.
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The NHS is to begin vaccinating healthy children under the age of five against swine flu, it has been confirmed. (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - November 20, 2009 Category: Nursing Source Type: news
Military Study Shows Prevention Of Novel A/H1N1 Virus Infection Is Vaccine-Type And Age-DependentEmail this article to a colleague.
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Immunization with either live attenuated influenza vaccine (LAIV, also known as FluMist®), or trivalent inactivated influenza vaccine (TIV), appears to offer a protection (~ 45%) against the novel A/H1N1 virus, the cause of the present influenza pandemic. However, the benefit was largely attributed to the youngest age group. The finding emerges from an evaluation of medical encounters and seasonal influenza immunization of U.S. military service members. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Swine Flu Source Type: news
AFFiRiS AG: Interim Analysis Of Clinical Phase I Data Triggered Decision To Move Alzheimer's Vaccine Candidate AD02 Into Clinical Phase II TestingEmail this article to a colleague.
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AFFiRiS AG will focus its Alzheimer's vaccine program on one product candidate at an unexpectedly early stage of development: the vaccine candidate AD02 is planned to enter into Phase II clinical trial early in 2010. This decision by the company immediately follows the completion of two Phase I trials with the candidates AD01 and AD02. The company based its fast decision on the first interim analysis of the secondary endpoints at the six month time point. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Alzheimer's / Dementia Source Type: news
AFFiRiS AG: Interim Analysis Of Clinical Phase I Data Triggered Decision To Move Alzheimer's Vaccine Candidate AD02 Into Clinical Phase II TestingEmail this article to a colleague.
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AFFiRiS AG will focus its Alzheimer's vaccine program on one product candidate at an unexpectedly early stage of development: the vaccine candidate AD02 is planned to enter into Phase II clinical trial early in 2010. This decision by the company immediately follows the completion of two Phase I trials with the candidates AD01 and AD02. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Military Study Shows Prevention Of Novel A/H1N1 Virus Infection Is Vaccine-Type And Age-DependentEmail this article to a colleague.
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Immunization with either live attenuated influenza vaccine (LAIV, also known as FluMist®), or trivalent inactivated influenza vaccine (TIV), appears to offer a protection (~ 45%) against the novel A/H1N1 virus, the cause of the present influenza pandemic. However, the benefit was largely attributed to the youngest age group. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Swine Flu Source Type: news
Inovio Biomedical Universal DNA Vaccine For Chikungunya Virus Demonstrates Protective Antibody Responses In Monkey ModelEmail this article to a colleague.
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Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced that the company's SynCon™ Chikungunya virus DNA vaccine induced protective neutralizing antibody responses in a preclinical non-human primate model. Dr. David B. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
Inovio Biomedical Universal DNA Vaccine For Chikungunya Virus Demonstrates Protective Antibody Responses In Monkey ModelEmail this article to a colleague.
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Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced that the company's SynCon™ Chikungunya virus DNA vaccine induced protective neutralizing antibody responses in a preclinical non-human primate model. Dr. David B. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
Immunologist At Children's Hospital Receives Daland Prize For Patient-Oriented ResearchEmail this article to a colleague.
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A pediatric immunologist at The Children's Hospital of Philadelphia has received a prestigious annual award from the American Philosophical Society, an organization founded in 1743 by Benjamin Franklin. Jordan S. Orange, M.D., Ph.D., received the Society's Judson Daland Prize on Nov. 13 for his contributions to research and treatment of inherited immune deficiency diseases. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Pediatrics / Children's Health Source Type: news
Catalina bison going on birth controlEmail this article to a colleague.
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The Catalina Island Conservancy has been rounding up the herd so females can get a reversible contraceptive vaccine. The goal: Control the size of the herd to keep it and the environment healthier.
Half a dozen men with walkie-talkies and cattle prods set out on foot at sunrise Thursday to coax a herd of 10 feral bison into a corral a mile away at the bottom of a Santa Catalina Island valley. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - November 20, 2009 Category: Science Source Type: news
Aspirin kills 400% more people than H1N1 swine fluEmail this article to a colleague.
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(NaturalNews) The CDC now reports that nearly 4,000 Americans have been killed by H1N1 swine flu. This number is supposed to sound big and scary, motivating millions of people to go out and pay good money to be injected with untested, unproven H1N1 vaccines. But let's put the number in perspective: Did you know that more than four times as many people are killed each year by common NSAID painkillers like aspirin?The July 1998 issue of The American Journal of Medicine explains it as follows:"Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for nonsteroidal anti-inflammatory dr...
Source: NaturalNews.com - November 20, 2009 Category: Consumer Health Advice Source Type: news
Batch of H1N1 vaccine causes adverse reactionsEmail this article to a colleague.
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More than 100,000 doses of the H1N1 vaccine were withdrawn Thursday, due to a warning that one particular batch of the vaccine had a higher than usual amount of adverse reactions among patients. (Source: CTV Health)
Source: CTV Health - November 20, 2009 Category: Consumer Health News Source Type: news
FDA Advisory Committee Finds Data Support The Safety And Effectiveness Of Prevnar 13™ Vaccine For The Prevention Of Invasive Pneumococcal DiseasEmail this article to a colleague.
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Pfizer Inc (NYSE:PFE) announced today that the U.S. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Immune System / vaccines Source Type: news
FDA Advisory Committee Finds Data Support The Safety And Effectiveness Of Prevnar 13™ Vaccine For The Prevention Of Invasive Pneumococcal DiseasEmail this article to a colleague.
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Pfizer Inc (NYSE:PFE) announced today that the U.S. Food and Drug Administration's (FDA) Vaccines and Related Biological Products Advisory Committee voted 10 to 1 that the data presented support the safety and effectiveness of its 13-valent pneumococcal conjugate candidate vaccine, Prevnar 13™ (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]), for the prevention of invasive pneumococcal disease in infants and young children. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Immune System / vaccines Source Type: news
Under-fives get swine flu jabsEmail this article to a colleague.
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Children under five will be the next group to be given priority in receiving the swine flu vaccine, Sir Liam Donaldson, the chief medical officer, said yesterday. The... (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - November 20, 2009 Category: Pharmaceuticals Source Type: news
Batch of H1N1 vaccine pulledEmail this article to a colleague.
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Health officials across Canada are being asked to hold back a batch of swine flu vaccine that appears to be causing higher rates of severe allergic reactions. (Source: CBC | Health)
Source: CBC | Health - November 20, 2009 Category: Consumer Health News Source Type: news
Last year's flu shot may help ward off swine flu, study showsEmail this article to a colleague.
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People who received last year's seasonal flu vaccine may have gained some protection against the swine flu virus, according to ... (Source: USATODAY.com Health)
Source: USATODAY.com Health - November 20, 2009 Category: Consumer Health News Source Type: news
All children under five to be offered swine flu jabEmail this article to a colleague.
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The UK swine flu vaccination programme is to be expanded to include all children under the age of five, the Joint Committee on Vaccination and Immunisation (JCVI) has recommended. (Source: HealthcareRepublic Independent Nurse News)
Source: HealthcareRepublic Independent Nurse News - November 20, 2009 Category: Nursing Source Type: news
Provinces to get 4.8M doses of H1N1 vaccineEmail this article to a colleague.
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A total of 4.8 million doses of the H1N1 vaccine will be delivered to the provinces by Sunday, CBC News has learned. (Source: CBC | Health)
Source: CBC | Health - November 20, 2009 Category: Consumer Health News Source Type: news
The economy-wide impact of pandemic influenza on the UK: a computable general equilibrium modelling experimentEmail this article to a colleague.
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Conclusion Balancing school closure against "business as usual" and obtaining sufficient stocks of effective vaccine are more important factors in determining the economic impact of an influenza pandemic than is the disease itself. Prophylactic absence from work in response to fear of infection can add considerably to the economic impact. (Source: BMJ Online First)
Source: BMJ Online First - November 20, 2009 Category: Journals (General) Authors: Smith, R. D, Keogh-Brown, M. R, Barnett, T., Tait, J. Tags: Infectious diseases, Epidemiologic studies, Immunology (including allergy) RESEARCH Source Type: journals
Adjuvant vaccines could have helped prevent H1N1 shortfall, drug manufacturers claimEmail this article to a colleague.
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Read the full story on MD Consult:
Adjuvant vaccines could have helped prevent H1N1 shortfall, drug manufacturers claim (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - November 20, 2009 Category: Journals (General) Source Type: info
H1N1 vaccine is safe, according to multiagency monitoringEmail this article to a colleague.
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Read the full story on MD Consult:
H1N1 vaccine is safe, according to multiagency monitoring (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - November 20, 2009 Category: Journals (General) Source Type: info
WHO officials try to allay fears about vaccine adverse effectsEmail this article to a colleague.
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WHO officials try to allay fears about vaccine adverse effects (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - November 20, 2009 Category: Journals (General) Source Type: info
Just-in-case flu sick days likely to hurt economyEmail this article to a colleague.
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Vaccine availability and ‘prophylactic absenteeism’ cost more than disease itself
Related items from OnMedicaGovernment offers health workers swine flu vaccine'Shaming' people into hand-washing - works best National flu service is set for launchFlu rate now higher than seasonal norm Influenza, a viral respiratory disease (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 20, 2009 Category: UK Health Source Type: news
FDA Panel Rejects Cell Culture Flu Vaccine, Wants More Safety DataEmail this article to a colleague.
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BETHESDA, Md. (MedPage Today) -- With members citing unanswered safety questions, an FDA advisory panel today narrowly rejected approval of the nation's first cell-based influenza vaccine -- an alternative to vaccines produced by the traditional, time-consuming method of growing the virus in eggs. (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - November 19, 2009 Category: Geriatrics Source Type: news
