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This page shows you the latest news and research items in this category.

Abdominal Coarctation and Associated Comorbidities in Children
ConclusionAbdominal coarctation is a rare anomaly. It is frequently associated with other vascular abnormalities. Vasculitis should be suspected in children with abdominal coarctation. All patients, even if treated, require continued close observation. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - May 13, 2013 Category: Cardiology Authors: John J. Parent, Edgard A. Bendaly, Roger A. Hurwitz Tags: Original Article Source Type: research

Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis
Conclusions This analysis suggests that AAV encompasses five classes associated with different outcomes. As compared with the traditional GPA–MPA separation, this classification system may better reflect the phenotypic spectrum of AAV. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Mahr, A., Katsahian, S., Varet, H., Guillevin, L., Hagen, E. C., Hoglund, P., Merkel, P. A., Pagnoux, C., Rasmussen, N., Westman, K., Jayne, D. R. W., for the French Vasculitis Study Group (FVSG) and the European Vasculitis Society (EUVAS) Tags: Vascularitis Clinical and epidemiological research Source Type: research

A vasculitis centre based management strategy leads to improved outcome in eosinophilic granulomatosis and polyangiitis (Churg-Strauss, EGPA): monocentric experiences in 150 patients
Conclusions Regular re-evaluation and target-orientated adaption of therapy may lead to normalization of life expectancy and attenuation of disease progression. Continued centre based interdisciplinary treatment should be standard of care. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Moosig, F., Bremer, J. P., Hellmich, B., Holle, J. U., Holl-Ulrich, K., Laudien, M., Matthis, C., Metzler, C., Nolle, B., Richardt, G., Gross, W. L. Tags: Immunology (including allergy), Drugs: musculoskeletal and joint diseases, Vascularitis, Epidemiology Clinical and epidemiological research Source Type: research

Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis
Conclusions These data suggest that GCSF, which is raised in patient serum, may play an important role in exacerbating disease in ANCA vasculitis. In addition, GCSF therapy for neutropenia should be used with caution in these patients. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Freeley, S. J., Coughlan, A. M., Popat, R. J., Dunn-Walters, D. K., Robson, M. G. Tags: Immunology (including allergy), Inflammation, Vascularitis Basic and translational research Source Type: research

Dnase1l3 mutations in hypocomplementemic urticarial vasculitis syndrome
Conclusion: These results show that HUVS is caused by mutations in DNASE1L3, encoding an endonuclease, which has been previously associated with SLE. © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - May 10, 2013 Category: Rheumatology Authors: Z.Birsin Ozcakar, Joseph Foster, Oscar Diaz‐Horta, Ozgur Kasapcopur, Yao‐Shan Fan, Fatos Yalcinkaya, Mustafa Tekin Tags: Full Length Source Type: research

Renal vasculitis
Conclusions: Our preliminary data suggests that both serum C3 consumption and TMA, as a consequence of AP hyperactivation, would determine a worse renal prognosis; consequently a precocious recognition of complement hyperactivation may allow an early treatment (i.e plasmapheresis, eculizumab) of acute renal failure in these cases. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Manenti, L., Signorini, L., Gnappi, E., Pilato, F. P., Vaglio, A., Allegri, L., Buzio, C., Bertram, A., Lovric, S., Park, J.-K., Becker, J. U., Haubitz, M., Kirsch, T., Jancova, E., Hruskova, Z., Lanska, V., Sedova, L., Olsanska, R., Jilek, D., Nemejc, P. Tags: Abstracts Source Type: research

Clinical nephrology - IgA nephropathy, lupus nephritis, vasculitis
Conclusions:In the selected patients with IgA nephropathy, telmisartan combined with leflunomide was safe and effective in decreasing proteinura and protecting short-term renal function. Larger randomized studies would be needed to confirm these results in the long run. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Wu, J., Duan, S., Li, W., Wang, Y., Liu, W., Zhang, J., Lun, L., Li, X., Zhou, C., Zheng, Y., Liu, S., Xie, Y., Cai, G., Chen, X., Shen, P., Li, Y., Wang, Z., Wang, W., Ren, H., Zhang, W., Chen, N., Shimamoto, M., Ohsawa, I., Suzuki, H., Nagamachi, S., Sh Tags: Abstracts Source Type: research

Practical algorithm for diagnosing patients with recurrent wheals or angioedema
ConclusionBy asking the right questions and performing a limited diagnostic workup as suggested here, this algorithm may help to establish the right diagnosis and treat patients early and more effectively. (Source: Allergy)
Source: Allergy - May 6, 2013 Category: Allergy & Immunology Authors: M. Maurer, M. Magerl, M. Metz, F. Siebenhaar, K. Weller, K. Krause Tags: Brief Communication Source Type: research

Rituximab Works in ANCA-Linked Vasculitis (CME/CE)
WASHINGTON (MedPage Today) -- Rituximab given as adjunctive therapy to children with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis dramatically lowered the dosage of cyclophosphamide needed for treatment, researchers said here. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - May 5, 2013 Category: Pediatrics Source Type: news

Lupus enteritis: from clinical findings to therapeutic management
In this study, we report a series of 7 new patients with this rare condition who were referred to French tertiary care centers and perform a systematic literature review of SLE cases fulfilling the revised ACR criteria, with evidence for small bowel involvement, excluding those with infectious enteritis. We describe the characteristics of 143 previously published and 7 new cases. Clinical symptoms mostly included abdominal pain (97%), vomiting (42%), diarrhea (32%) and fever (20%). Laboratory features mostly reflected lupus activity: low complement levels (88%), anemia (52%), leukocytopenia or lymphocytopenia (40%) and thr...
Source: Orphanet Journal of Rare Diseases - May 3, 2013 Category: Internal Medicine Authors: Peter JanssensLaurent ArnaudLionel GalicierAlexis MathianMiguel HieDamien SeneJulien HarocheCatherine Veyssier-BelotIsabelle Huynh-CharlierPhilippe GrenierJean-Charles PietteZahir Amoura Source Type: research

MPO Transfer to Endothelium [Cell Biology]
Atherosclerosis and vasculitis both feature inflammation mediated by neutrophil-endothelial cell (EC) contact. Neutrophil myeloperoxidase (MPO) can disrupt normal EC function, although the mechanism(s) by which MPO is transferred to ECs are unknown. We tested the hypothesis that close, β2 integrin-dependent neutrophil-EC contact mediates MPO transfer from neutrophils to ECs. We used sensitive MPO assays and flow cytometry to detect MPO in ECs and demonstrate that ECs acquired MPO when contacted by neutrophils directly but not when ECs and neutrophils were separated in Transwells. The transfer was dependent on neutrophil n...
Source: Journal of Biological Chemistry - May 3, 2013 Category: Chemistry Authors: Jerke, U., Rolle, S., Purfurst, B., Luft, F. C., Nauseef, W. M., Kettritz, R. Tags: Cell Biology Source Type: research

Chronic ulceration of the leg
Abstract: The assessment and treatment of patients with chronic leg ulcers represents a significant burden to community and secondary care services in the United Kingdom. Most leg ulcers are due to chronic venous hypertension, although arterial compromise, malignancy and vasculitis are also recognized causes. The assessment of patients with chronic leg ulceration should include a detailed history and clinical examination, supported by relevant investigations. The mainstay of treatment for patients with chronic venous ulceration is multilayer compression bandaging, applied by trained staff working within a specialist servic...
Source: Surgery (Medicine Publishing) - May 1, 2013 Category: Surgery Authors: Manj S. Gohel, Keith R. Poskitt Tags: Vascular surgery - II Source Type: research

Immune complexes activate human endothelium involving the cell-signaling HMGB1-RAGE axis in the pathogenesis of lupus vasculitis
& Yueran Zhao (Source: Laboratory Investigation AOP)
Source: Laboratory Investigation AOP - April 29, 2013 Category: Laboratory Medicine Authors: Wenping SunYulian JiaoBin CuiXuejun GaoYu XiaYueran Zhao Tags: endothelial activation HMGB1-RAGE axis immune complexes lupus vasculitis NF-κB systemic lupus erythematosus Source Type: research

Teaching NeuroImages: Longitudinally extensive transverse myelitis in neuro-Behcet disease
A 25-year-old man presented with subacute spastic paraparesis. He reported 2 previous episodes of spastic paraparesis with partial recovery. Recurrent oral and genital ulceration, pustular skin eruptions, and fever coexisted. Profound motor weakness, a sensory level at T10, oral ulceration, and a pustular eruption on the anterior abdominal wall were noted. Marked neutrophilia was noted in both blood and CSF. Neuromyelitis optica–immunoglobulin G autoantibody was negative. MRI (figure) demonstrated marked inflammatory changes. IV and oral steroids, followed by 6 months of pulsed IV cyclophosphamide, resulted in marked...
Source: Neurology - April 29, 2013 Category: Neurology Authors: Graham, D., McCarthy, A., Kavanagh, E., O'Rourke, K., Lynch, T. Tags: MRI, Vasculitis, Transverse myelitis RESIDENT AND FELLOW SECTION Source Type: research

Etiological profile of epilepsia partialis continua among adults in a tertiary care hospital
Conclusion: EPC is a rare type of focal motor status epilepticus. Treatment of the underlying cause in addition to controlling EPC is essential to achieve the good outcomes. (Source: Neurology India)
Source: Neurology India - April 29, 2013 Category: Neurology Authors: Vikrant ShrivastavaNishkala Prabhu BurjiLakshya J BasumataryMarami DasMunundra GoswamiAshok Kumar Kayal Source Type: research

Metal Ions Activate Vascular Endothelial Cells and Increase Lymphocyte Chemotaxis and Binding
Abstract Metal on metal articulations in hip arthroplasty offer advantages, including lower volumetric wear compared to conventional metalonpolyethylene bearings, and increased resistance to dislocation. Reports described early failures, with histologic features similar to a Type IV immune response. Mechanisms by which metal wear products cause this reaction are not completely understood. We hypothesized a mechanism through direct activation of endothelial cells (ECs) by metal ions, resulting in both vasculitis and accumulation of lymphocytes without prior immune sensitization. Effects of metal ions were evaluated using hu...
Source: Journal of Orthopaedic Research - April 29, 2013 Category: Orthopaedics Authors: James T. Ninomiya, Scott A. Kuzma, Timothy J. Schnettler, John G. Krolikowski, Janine A. Struve, Dorothee Weihrauch Tags: Research Article Source Type: research

Clinical and laboratory characteristics of nineteen patients with Churg‐Strauss syndrome from a single South Australian centre
ConclusionsThis is the first Australian study to focus on CSS. Our results demonstrate similar presentation and prognosis of CSS to previous descriptions, however we noted that musculoskeletal involvement was more common in ANCA+ patients. In our series thrombosis was a significant complication and we suggest that thromboprophylaxis may be warranted. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - April 28, 2013 Category: Internal Medicine Authors: Andrew Francis Whyte, William Bernard Smith, Swati Ninad Sinkar, Frank Eric Kette, Pravin Hissaria Tags: Original Article Source Type: research

Steroids, Relapse Predict Damage from Vasculitis (CME/CE)
(MedPage Today) -- BIRMINGHAM, England -- Patients with systemic vasculitis who require steroids for long periods or who have multiple relapses are likely to have extensive, irreversible organ damage, a researcher said here. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - April 27, 2013 Category: Primary Care Source Type: news

Childhood Central Nervous System Vasculitis
This article focuses on childhood CNS vasculitis. (Source: Neuroimaging Clinics)
Source: Neuroimaging Clinics - April 23, 2013 Category: Radiology Authors: Mahendranath Moharir, Manohar Shroff, Susanne M. Benseler Source Type: research

Antineutrophil Cytoplasmic Autoantibodies: An Unbiased and Efficient Tool to Classify Renal Vasculitis? Comment on the Article by Lionaki et al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 23, 2013 Category: Rheumatology Authors: Luis Corral‐Gudino Tags: Letters Source Type: research

Pro-inflammatory cytokine and caspase-1 responses to pattern recognition receptor activation of neutrophils and dendritic cells in Behcet's disease
Conclusion. Inflammasome formation following stimulation with NOD1/NOD2 and RIG measured by caspase-1 activation, cytokine levels and expression of RIP2 and p38 seems to be functionally normal in DCs and neutrophils of BD patients, although slightly defective responses in some pathways and cytokine levels were observed. These results may suggest that caspase-1-independent pathways such as toll-like receptors may be more prominent in BD pathogenesis. (Source: Rheumatology)
Source: Rheumatology - April 19, 2013 Category: Rheumatology Authors: Ture-Ozdemir, F., Tulunay, A., Elbasi, M. O., Tatli, I., Maurer, A.-M., Mumcu, G., Direskeneli, H., Eksioglu-Demiralp, E. Tags: Vasculitis BASIC SCIENCE Source Type: research

Orbital masses in granulomatosis with polyangiitis are associated with a refractory course and a high burden of local damage
Conclusion. Orbital masses are a rare manifestation of GPA and are characterized by a refractory course and by a high rate of local damage. Patients with a refractory or relapsing course are at higher risk of developing blindness. (Source: Rheumatology)
Source: Rheumatology - April 19, 2013 Category: Rheumatology Authors: Holle, J. U., Voigt, C., Both, M., Holl-Ulrich, K., Nolle, B., Laudien, M., Moosig, F., Gross, W. L. Tags: Vasculitis CLINICAL SCIENCE Source Type: research

Mycoplasma pneumoniae: an aetiological agent of acute haemorrhagic oedema of infancy
Abstract Acute haemorrhagic oedema of infancy (AHEI) is considered a separate clinical entity among cutaneous small vessel vasculitis of childhood. It usually occurs in children younger than 2 years of age, with spontaneous recovery occurring within a few weeks. A history of recent upper respiratory or urinary tract infections or immunisation is found in most patients. Although Mycoplasma pneumoniae has been linked to a wide array of skin eruptions or diseases, it is not recognised as a possible cause of acute haemorrhagic oedema of infancy. The authors report a child with AHEI and a concurrent M. pneumoniae infection. (So...
Source: Australasian Journal of Dermatology - April 17, 2013 Category: Dermatology Authors: Vito Di Lernia Tags: Brief Report Source Type: research

Relationship among antineutrophil cytoplasmic antibody, blood urea nitrogen and complement in patients with eosinophilic granulomatosis polyangiitis (Churg–Strauss syndrome)
We examined EGPA patients with cutaneous manifestations as an initial sign and investigated the correlations among clinical, serological and histopathological findings. We focused on differences among ANCA, blood urea nitrogen and complement levels such as complement 3 (C3), C4 and total complement hemolytic activity (CH50). We retrospectively investigated the records of 22 patients (11 male and 11 female) with EGPA admitted to our hospital from 1997–2012. Ten of the 22 patients (46%) were positive for serum myeloperoxidase (MPO)‐ANCA. In contrast, all the patients were negative for serum proteinase 3 ANCA. There was a...
Source: The Journal of Dermatology - April 17, 2013 Category: Dermatology Authors: Tamihiro Kawakami, Satoko Kimura, Sora Takeuchi, Yoshinao Soma Tags: Original Article Source Type: research

Coronary artery dilatation and vasculitis in a case of rabies: Similarity with Kawasaki disease?
We report the unusual combination between rabies, coronary dilatation on echocardiography and coronary vasculitis documented upon autopsy. In the search for the etiological agent of Kawasaki disease, we suggest that a viral infection with potential antigenic similarities to rabies virus should be entertained. (Source: Pediatrics International)
Source: Pediatrics International - April 16, 2013 Category: Pediatrics Authors: Ibtissama Boukas, Nagib Dahdah, Yves Robitaille, Anne Fournier Tags: PATIENT REPORT Source Type: research

Pulmonary-renal syndrome: a life threatening but treatable condition
Pulmonary renal syndrome (PRS) describes the occurrence of renal failure in association with respiratory failure, characterised by autoimmune-mediated rapidly progressive glomerulonephritis (RPGN) and diffuse alveolar haemorrhage (DAH), respectively. PRS is associated with significant morbidity and mortality, and prompt diagnosis and treatment significantly improve outcomes. Prompt diagnosis of PRS requires a high index of suspicion, as clinical features are non-specific, and immunological testing aids the diagnosis in many cases. The diagnostic evaluation of DAH and RPGN is outlined in the context of the important differe...
Source: Postgraduate Medical Journal - April 16, 2013 Category: Journals (General) Authors: West, S. C., Arulkumaran, N., Ind, P. W., Pusey, C. D. Tags: Reviews Source Type: research

Anxiety UK assists the launch of first online patient support centre for Vasculitis sufferers
Anxiety UK has been commissioned to assist with the first online patient support centre for Vasculitis sufferers following months of work by the Lauren Currie Twilight Foundation (LCTF). The charity was set up two years ago by Adrienne and Grant Currie following the death of their daughter Lauren from Vasculitis. The new patient support centre [...] (Source: ANXIETY UK News)
Source: ANXIETY UK News - April 12, 2013 Category: Psychiatry Source Type: news

Update on Kawasaki disease: Epidemiology, aetiology and pathogenesis
Abstract Kawasaki disease is an acute systemic vasculitis predominantly affecting young children. It is due to an abnormal host response to as yet unidentified infectious trigger(s). Kawasaki disease may cause coronary artery damage, long‐term cardiovascular morbidity and occasionally mortality, especially if the diagnosis is missed or timely treatment is not given. This is the first of two updates on Kawasaki disease. Here we review recent advances in epidemiology, possible aetiologies, host susceptibility and pathogenesis of this fascinating condition. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - April 7, 2013 Category: Pediatrics Authors: Deane Yim, Nigel Curtis, Michael Cheung, David Burgner Tags: Review Article Source Type: research

GlaxoSmithKline announces start of phase III study of Benlysta® (belimumab ) in patients with vasculitis
GlaxoSmithKline plc (GSK) today announced the start of a Phase III study to evaluate Benlysta® (belimumab) in patients with ANCA (Anti-neutrophil Cytoplasmic Antibodies) positive vasculitis – a condition that involves inflammation of the blood vessels. (Source: GSK news)
Source: GSK news - April 3, 2013 Category: Pharmaceuticals Source Type: news

Levamisole‐induced myopathy and leukocytoclastic vasculitis: a case report and literature review
Abstract Levamisole, an immunomodulator and anthelmintic medication, has been used in dermatology for years. Even though the adverse effects are usually mild and reversible, attention should be paid toward severe events such as vasculitis and neutropenia. To the best of our knowledge, this is the first case report on a patient presenting with myopathy caused by levamisole. Here, we report a 34‐year‐old woman with recalcitrant warts who received levamisole 100 mg daily for 5 days. Subsequently, bilateral lower limb weakness accompanied by multiple painful and non‐blanchable purpura was noted. Levamisole‐induced ...
Source: Dermatologic Therapy - April 1, 2013 Category: Dermatology Authors: Meng‐Hsuan Tsai, Jen‐Hung Yang, Sheng‐Ling Kung, Yu‐Ping Hsiao Tags: Therapeutic Hotline Source Type: research

Prevalence of stenoses and occlusions of brain-supplying arteries in young stroke patients
Conclusions: We observed a substantial proportion of atherosclerotic carotid artery stenoses and occlusions in younger stroke patients. Intracranial stenoses and occlusions were even more prevalent than extracranial carotid artery disease. Together with nonstenotic plaques, one-fifth of patients (21.2%) had symptomatic or asymptomatic large-artery atherosclerosis, which should encourage future stroke prevention campaigns to target risk factor modification in young people. (Source: Neurology)
Source: Neurology - April 1, 2013 Category: Neurology Authors: von Sarnowski, B., Schminke, U., Tatlisumak, T., Putaala, J., Grittner, U., Kaps, M., Tobin, W. O., Kinsella, J. A., McCabe, D. J. H., Hennerici, M. G., Fazekas, F., Norrving, B., Kessler, C., Rolfs, A., On behalf of the sifap1 investigators Tags: Stroke in young adults, Ultrasound, Prevalence studies, Risk factors in epidemiology ARTICLE Source Type: research

ANCA‐associated vasculitis patients have defective Treg function exacerbated by presence of a suppression‐resistant effector population
Conclusion:ANCA‐associated vasculitis is associated with disruption of the suppressive Treg network and increased frequency of a distinct pro‐inflammatory effector T cell subset which comprises the majority of peripheral CD4+ T cells. © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 1, 2013 Category: Rheumatology Authors: Meghan E Free, Donna O Bunch, JulieAnne McGregor, Britta E Jones, Elisabeth A Berg, Susan L Hogan, Yichun Hu, Gloria A Preston, J. Charles Jennette, Ronald J Falk, Maureen A Su Tags: Full Length Source Type: research

Concurrent Basilar Artery Double Fenestration With Aneurysm and Vertebral Artery Dissection: Case Report and Literature Review of Rare Cerebrovascular Abnormalities
This report presents a case of concurring vertebral artery dissection and double fenestration of the basilar artery with aneurysm. The fenestration and FMD are considered possible main contributing causes of this presentation. A literature review of cerebrovascular fenestration and FMD is provided and the relationship between the 2 is considered. Lastly, the use of antithrombotic therapy in the setting of subarachnoid hemorrhage, dissection, and stent placement is discussed. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - April 1, 2013 Category: Surgery Authors: Madeline M. Stark, Nedaa Skeik, Josser E. Delgado Almandoz, Benjamin M. Crandall, David E. Tubman Tags: Case Report Abstracts Source Type: research

Endovascular Treatment of Aortic and Primitive Iliac Artery Aneurysms Associated With Behçet Disease
We describe a 42-year-old woman with an aortic aneurysm and common right iliac aneurysm, both saccular and complicating Behçet disease. The patient was successfully treated by an endovascular method, which currently seems to be the best therapeutic choice given the frequent anastomotic complications of conventional surgical treatment. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - March 29, 2013 Category: Surgery Authors: Caroline Ducos, Alberic de Lambert, Augustin Pirvu, Emmanuel Cochet, Carmine Sessa, Jean-Luc Magne Tags: Case Report Abstracts Source Type: research

Using Rituximab Plus Fludarabine and Cyclophosphamide as a Treatment for Refractory Mixed Cryoglobulinemia Associated With Lymphoma
ConclusionThe FCR regimen represents an effective treatment in severe and refractory MC. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - March 28, 2013 Category: Rheumatology Authors: D. Saadoun, M. Pineton de Chambrun, O. Hermine, A. Karras, S. Choquet, P. Jego, O. Decaux, P. Cacoub Tags: Brief Report Source Type: research

Lung manifestations in MPO‐ANCA associated vasculitides in children
ConclusionsDiffuse alveolar hemorrhage complicates 40% of cases of MPO‐ANCA associated vasculitides in children with renal involvement. After an acute potentially severe phase, a complete recovery without significant functional impairment was observed in four of five affected children. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 26, 2013 Category: Respiratory Medicine Authors: Salma Ben Ameur, Patrick Niaudet, Véronique Baudouin, Muriel Le. Bourgeois, Véronique Houdouin, Christophe Delacourt, Alice Hadchouel Tags: Original Article: Other Source Type: research

LCTF and Anxiety UK live webinar will discuss anxiety with Vasculitis
The Lauren Currie Twilight Foundation (LCTF) and Anxiety UK will host a live webinar presented by Paul Murricane, the former BAFTA nominated producer for Dispatches and Equinox documentaries, at 2.30pm on Tuesday 9th April 2013. The webinar will also feature guest speakers Andrew Johnson, who produces relaxation and sleep support CD therapies for the NHS [...] (Source: ANXIETY UK News)
Source: ANXIETY UK News - March 19, 2013 Category: Psychiatry Source Type: news

A fatal attraction: eosinophils and the heart
(Source: Rheumatology)
Source: Rheumatology - March 19, 2013 Category: Rheumatology Authors: Moosig, F., Richardt, G., Gross, W. L. Tags: Vasculitis EDITORIALS Source Type: research

Temporal ultrasonography findings in temporal arteritis: early disappearance of halo sign after only 2 days of steroid treatment
(Source: Rheumatology)
Source: Rheumatology - March 19, 2013 Category: Rheumatology Authors: Santoro, L., D'Onofrio, F., Bernardi, S., Gremese, E., Ferraccioli, G., Santoliquido, A. Tags: Vasculitis, Diagnostics and Imaging Procedures CLINICAL VIGNETTES Source Type: research

Churg-Strauss syndrome cardiac involvement evaluated by cardiac magnetic resonance imaging and positron-emission tomography: a prospective study on 20 patients
Conclusion. For CSS patients in remission, CMRI detected subclinical active myocardial lesions and could be recommended to assess cardiac involvement. However, because CMRI-detected MDE can reflect fibrosis or inflammation, FDG-PET might help to distinguish between the two. (Source: Rheumatology)
Source: Rheumatology - March 19, 2013 Category: Rheumatology Authors: Marmursztejn, J., Guillevin, L., Trebossen, R., Cohen, P., Guilpain, P., Pagnoux, C., Mouthon, L., Legmann, P., Vignaux, O., Duboc, D. Tags: Vasculitis CLINICAL SCIENCE Source Type: research

Getting rid of MPO-ANCA: a matter of disease subtype
(Source: Rheumatology)
Source: Rheumatology - March 19, 2013 Category: Rheumatology Authors: Bremer, J. P., Csernok, E., Holle, J., Gross, W. L., Moosig, F. Tags: Vasculitis OTHERS Source Type: research

Successful {alpha}1-antitrypsin replacement therapy in a patient with {alpha}1-antitrypsin deficiency and granulomatosis with polyangiitis
(Source: Rheumatology)
Source: Rheumatology - March 19, 2013 Category: Rheumatology Authors: Hernandez Perez, J. M., Fumero Garcia, S., Alvarez Pio, A. Tags: Vasculitis CASE REPORTS Source Type: research

Potential diagnostic pitfall in direct immunofluorescence evaluation for vasculitis in skin biopsies: fluorescent secretory granules within eccrine glands
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - March 8, 2013 Category: Pathology Authors: Julia S. Lehman, Michael J. Camilleri Tags: Letter to the Editor Source Type: research

Primary cutaneous marginal zone lymphoma associated with juxta‐articular fibrotic nodules in a teenager
Primary cutaneous marginal zone lymphoma (PCMZL) has rarely been reported in teenagers and is occasionally associated with Borrelia burgdorferi infection. Juxta‐articular fibrotic nodules represent a unique, localized fibrosing response to spirochete infections, namely Borreliosis. Herein, we report a 15‐year‐old healthy boy who presented with a 4‐year history of progressive acquisition of asymptomatic, erythematous nodules, ≤3 cm, beginning with his right forearm (3), then right arm (1) and lastly his right inner thigh (1). Biopsy showed PCMZL in three of five samples, and inflamed, fibrotic nodules, near the ...
Source: Journal of Cutaneous Pathology - March 8, 2013 Category: Pathology Authors: Pooja Ghatalia, Joanne Porter, Danielle Wroblewski, John Andrew Carlson Tags: Case Report Source Type: research

Is it lucio phenomenon or necrotic erythema nodosum leprosum?
PSS Ranugha, Laxmisha Chandrashekar, Rashmi Kumari, Devinder M Thappa, Bhawana BadheIndian Journal of Dermatology 2013 58(2):160-160Lucio phenomenon (LP) or erythema necroticans is a relatively rare, peculiar reaction pattern occurring in untreated lepromatous (LL) or borderline lepromatous (BL) leprosy cases. A 38-year-old male, a cook by occupation, was referred to the dermatology clinic from otolaryngology department with blistering over both the hands and feet of 2 days duration. He had been admitted 1 week back with epistaxis and nasopharyngeal myiasis in otolaryngology department. He was started on systemic antibioti...
Source: Indian Journal of Dermatology - March 5, 2013 Category: Dermatology Authors: PSS RanughaLaxmisha ChandrashekarRashmi KumariDevinder M ThappaBhawana Badhe Source Type: research

Coincidence of granulomatosis and polyangiitis with atypical clinical manifestation and antiphospholipid syndrome.
Abstract Granulomatosis and angiitis (GPA) is a multisystemic disease characterized by a granulomatous inflammation, tissue necrosis, and vasculitis of small and medium-sized blood vessels. Although the disease has a predilection for the upper respiratory tract, lungs, and kidneys, any organ system may be affected. Here, we present a case of generalized GPA manifested initially by necrotizing isolated parotitis and later by pulmonary-renal syndrome. Simultaneously with pulmonary hemorrhage, our patient developed an antiphospholipid syndrome (APS) presenting with deep vein thrombosis and strongly positive lupus anti...
Source: Lupus - March 4, 2013 Category: Rheumatology Authors: Shovman O, Langevitz P, Gilburd B, Shoenfeld Y Tags: Lupus Source Type: research

Central nervous system vasculitis associated with linear scleroderma
Zai-qiang Zhang, Di TianNeurology India 2013 61(1):78-80 (Source: Neurology India)
Source: Neurology India - March 4, 2013 Category: Neurology Authors: Zai-qiang ZhangDi Tian Source Type: research

Microscopic polyangiitis complicated with ileal involvement detected by double-balloon endoscopy: a case report
Conclusion: The cause of gastrointestinal involvement in microscopic polyangiitis is ischemia due to vasculitis. It is difficult to diagnose small-vessel vasculitis by endoscopic biopsy. Although histological evidence of microscopic polyangiitis is important, the treatment should not be delayed by repeating the biopsy, because such delay can result in adverse sequelae.This case report shows that microscopic polyangiitis should be considered as a differential diagnosis when small intestinal changes like those in the present case are observed by endoscopy. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - March 2, 2013 Category: Gastroenterology Authors: Masashi FukushimaSatoko InoueYuichiro OnoYoshitaka TamakiHajime YoshimuraYukihiro ImaiTetsuro Inokuma Source Type: research

Intravenous immunoglobulin as adjuvant therapy for Wegener's granulomatosis.
CONCLUSIONS: There is insufficient evidence from one RCT that IVIg adjuvant therapy provides a therapeutic advantage compared with the combination of steroids and immunosuppressants for patients with WG. Given the high cost of IVIg (one dose at 2 g/kg for a 70 kg patient = $8,400), it should be limited to treat WG in the context of a well conducted RCT powered to detect patient-relevant outcomes. PMID: 23440811 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 1, 2013 Category: Journals (General) Authors: Fortin PM, Tejani AM, Bassett K, Musini VM Tags: Cochrane Database Syst Rev Source Type: research

A genome-wide association analysis identifies novel susceptibility loci for coronary arterial lesions in patients with Kawasaki disease
Kawasaki disease (KD) is an acute pediatric systemic vasculitis. The incidence in Taiwan is the third highest globally. Despite intravenous immunoglobulin therapy, 5%-10% of patients with KD still develop coronary arterial lesions (CAL). Several genome-wide association studies (GWAS) have identified genetic variants of ITPKC, FCGR2A, BLK, and CD40 genes as risk factors of KD. Genetic susceptibility for the development of CAL had also been described. By conducting a GWAS in a Taiwanese KD cohort, we sought to identify novel genetic susceptibility for CAL. (Source: Translational Research)
Source: Translational Research - March 1, 2013 Category: Research Authors: Ming-Tai Lin, Chia-Lin Hsu, Pei-Lung Chen, Wei-Shiung Yang, Jou-Kou Wang, Cathy S.J. Fann, Mei-Hwan Wu, Taiwan Pediatric CV Group Tags: Genetic Polymorphism-Disease Association Source Type: research