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Modeling of drug solubility in supercritical carbon dioxide using equation of state based on hole theory with molecular surface charge density
Publication date: December 2014 Source:Chemical Engineering Research and Design, Volume 92, Issue 12 Author(s): Junichi Sakabe , Hirohisa Uchida , Yusuke Shimoyama Equation of state based on hole theory with molecular surface charge density was developed for the modeling of drug solubility in supercritical carbon dioxide. In the hole theory, the density change of supercritical carbon dioxide can be represented by the number of holes in the system. The molecular interaction energy parameter was estimated using the interactions of segments on the molecular surface given by a quantum calculation using conductor-like screeni...
Source: Chemical Engineering Research and Design - December 8, 2014 Category: Chemistry Source Type: research

Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice
Conclusions: These data demonstrate that ATB-346 can be efficacious in a TBI animal model by reducing the secondary inflammation and tissue injury. Therefore, ATB-346 could represent an interesting approach for the management of secondary damage following CNS diseases, counteracting behavioral changes and inflammatory process. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 4, 2014 Category: Neurology Authors: Michela CampoloEmanuela EspositoAkbar AhmadRosanna Di PaolaIrene PaternitiMarika CordaroGiuseppe BruschettaJohn WallaceSalvatore Cuzzocrea Source Type: research

Pharmacokinetic Comparison Study of a Combination Containing 500 mg of Naproxen and 20 mg of Esomeprazole: A Randomized, Single-Dose, 2-Way Crossover, Open-Label Study in Healthy Korean Men.
This study was performed for the subsequent marketing of a combination drug that contained 500 mg of naproxen and 20 mg of esomeprazole in Korea. We evaluated the comparative bioavailability and tolerability of the test and reference formulations in healthy men. METHODS: A total of 60 healthy men were enrolled in this single-dose, randomized, open-label, 2-period, 2-sequence, crossover study. During each period, men received a combination of 500 mg of naproxen and 20 mg of esomeprazole for test or reference, and between each period, there was a 1-week washout period. Blood samples were obtained 21 times throughout each...
Source: Clinical Therapeutics - December 4, 2014 Category: Drugs & Pharmacology Authors: Choi HG, Jeon JY, Kwak SS, Kim H, Jin C, Im YJ, Kim EY, Wang HM, Kim Y, Lee SY, Kim MG Tags: Clin Ther Source Type: research

Efficacy of etoricoxib, celecoxib, lumiracoxib, non-selective NSAIDs, and acetaminophen in osteoarthritis: a mixed treatment comparison.
CONCLUSION: The current study estimated the efficacy of acetaminophen, nsNSAIDs, and COX-2 selective NSAIDs in OA and found that etoricoxib 30 mg is likely to result in the greatest improvements in pain and physical function. Differences in PGADS between interventions were smaller. PMID: 22582102 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - December 2, 2014 Category: Rheumatology Tags: Open Rheumatol J Source Type: research

Comparison of the effect of Naproxen, Etodolac and Diclofenac on postoperative sequelsfollowing third molar surgery: a randomised, double-blind, crossover study.
CONCLUSION: NSAIDs (Diclofenac, Naproxen and Etodolac) are somehow similarly effective for controlling pain and trismus following extraction of mandibular third molars but Diclofenac potassium surpasses others in reduction of swelling. PMID: 24316711 [PubMed - in process] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - December 2, 2014 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research

Undetected Ultracet™ dependence in an adolescent with nonmalignant back pain.
This report discusses an 18-year-old woman with idiopathic scoliosis and clinical depression secondary to undertreated refractory chronic back pain who underwent surgery to correct pseudoarthrosis after a prior spinal instrumentation operation. This intervention in conjunction with a course of patient-controlled analgesia, hydromorphone, and outpatient tramadol, naproxen, methadone, and gabapentin was successful in addressing her long-standing lumbar pain. The patient, however, continued to complain to her pain management team of postsurgical discomfort and insisted on being prescribed Ultracet™ (acetaminophen-tramadol) ...
Source: Journal of Opioid Management - December 2, 2014 Category: Addiction Tags: J Opioid Manag Source Type: research

Functional Adrenal Insufficiency Complicating an Overdose of Naproxen and Ibuprofen
(Source: Clinical Pediatrics)
Source: Clinical Pediatrics - December 2, 2014 Category: Pediatrics Authors: Akingbola, O. A., Singh, D., Kleinman, J. A., Frieberg, E. M. Tags: Brief Reports Source Type: research

Competitive adsorption of selected non-steroidal anti-inflammatory drugs on activated biochars: Experimental and molecular modeling study
Publication date: 15 March 2015 Source:Chemical Engineering Journal, Volume 264 Author(s): Chanil Jung , Linkel K. Boateng , Joseph R.V. Flora , Jeill Oh , Marcus C. Braswell , Ahjeong Son , Yeomin Yoon The adsorption of targeted non-steroidal anti-inflammatory drugs: diclofenac (DCF), naproxen (NPX), and ibuprofen (IBP) by two types of activated biochar (N-/O-biochar) was studied in single- and multi-solute adsorption experiments in conjunction with molecular modeling subsequently interpreting the binding energy. The carbonaceous structure of the biochars was elucidated via nuclear magnetic resonance and the intensity o...
Source: Chemical Engineering Journal - December 1, 2014 Category: Chemistry Source Type: research

Double-blind, placebo-controlled, crossover study of early-intervention with sumatriptan 85/naproxen sodium 500 in (truly) episodic migraine: what's neck pain got to do with it?
CONCLUSION: Our study results support a fundamental re-evaluation of the role of neck pain in migraine. PMID: 24685971 [PubMed - indexed for MEDLINE] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - November 28, 2014 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial
Conclusions Paracetamol/CR oxycodone and paracetamol/naproxen are equally effective in treatment of acute postoperative pain at home after ambulatory surgery with comparable patient satisfaction level. We suggest paracetamol/CR oxycodone to be a valuable alternative for the current paracetamol/naproxen gold standard, particularly in patients with a contraindication for nonsteroidal anti-inflammatory drugs. identifier: NCT02152592. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 28, 2014 Category: Drugs & Pharmacology Source Type: research

Comparison of the postoperative analgesic effects of naproxen sodium and naproxen sodium-codeine phosphate for arthroscopic meniscus surgery
Conclusions The combination of naproxen sodium-codeine phosphate provided more effective analgesia than naproxen sodium and did not increase side effects. (Source: Brazilian Journal of Anesthesiology)
Source: Brazilian Journal of Anesthesiology - November 28, 2014 Category: Anesthesiology Source Type: research

Aspirin-dependent cyclooxygenase acetylation [Medical Sciences]
The cardiovascular safety of nonsteroidal antiinflammatory drugs (NSAIDs) may be influenced by interactions with antiplatelet doses of aspirin. We sought to quantitate precisely the propensity of commonly consumed NSAIDs—ibuprofen, naproxen, and celecoxib—to cause a drug–drug interaction with aspirin in vivo by measuring the target engagement of aspirin directly by MS.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 25, 2014 Category: Science Authors: Li, X., Fries, S., Li, R., Lawson, J. A., Propert, K. J., Diamond, S. L., Blair, I. A., FitzGerald, G. A., Grosser, T. Tags: Biological Sciences Source Type: research

Hydrogen sulphide protects against NSAID‐enteropathy through modulation of bile and the microbiota
Conclusions and ImplicationsHydrogen sulphide protects against NSAID‐enteropathy in rats, in part reducing the cytotoxicity of bile and preventing NSAID‐induced dysbiosis. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: Rory W Blackler, Jean‐Paul Motta, Anna Manko, Matthew Workentine, Premysl Bercik, Michael G Surette, John L Wallace Tags: RESEARCH PAPER Source Type: research

Atrial fibrillation in patients undergoing surgical revascularization: an update on pharmacologic prophylaxis.
Authors: Rostagno C Abstract Atrial fibrillation occurs in 20-50% of patients after surgical revascularization (40% have more than 1 episode), with a peak between 2nd and 3rd postoperative days. Postoperative atrial fibrillation (POAF) has been associated with an increase in adverse events, length of hospital stay and, therefore, cost of care, and late mortality. A higher risk profile in patients who develop POAF may contribute to the higher late mortality rate. The pathogenesis of PAOF is multi factorial: transient ischemia during surgical procedure, neurohormonal activation, electrolyte imbalance, fluid overload ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Characterization of cefalexin degradation capabilities of two Pseudomonas strains isolated from activated sludge
Publication date: 23 January 2015 Source:Journal of Hazardous Materials, Volume 282 Author(s): Bokun Lin , Jinling Lyu , Xian-jin Lyu , Han-qing Yu , Zhong Hu , James C.W. Lam , Paul K.S. Lam Pharmaceuticals have recently been regarded as contaminants of emerging concern. To date, there is limited knowledge about antibiotic-degrading microorganisms in conventional activated sludge treatment systems and their characteristics toward antibiotic degradation especially in the presence of a pharmaceutical mixture. As such, antibiotic-degrading microorganisms were investigated and isolated from the activated sludge, and their d...
Source: Journal of Hazardous Materials - November 21, 2014 Category: Environmental Health Source Type: research

Molecular Dynamics Simulations of Complex Mixtures Aimed at the Preparation of Naproxen-Imprinted Xerogels
Journal of Chemical Information and ModelingDOI: 10.1021/ci5004575 (Source: Journal of Chemical Information and Modeling)
Source: Journal of Chemical Information and Modeling - November 19, 2014 Category: Chemistry Authors: Riccardo Concu, Martin Perez, M. Natália D. S. Cordeiro and Manuel Azenha Source Type: research

Assessment of organotins against the linoleic acid, glutathione and CT-DNA
Publication date: 1 November 2014 Source:Inorganica Chimica Acta, Volume 423, Part B Author(s): C.N. Banti , E.I. Gkaniatsou , N. Kourkoumelis , M.J. Manos , A.J. Tasiopoulos , T. Bakas , S.K. Hadjikakou The already known di-n-butyltin(IV) complex of the chiral anti-inflammatory drug naproxen (Hnapr) of formula [(n-Bu-)2Sn(nap)2] (1), was re-synthesized here with an alternative method and it was used for the assessment of organotins towards the linoleic acid which is located in the cell membrane, the intracellular glutathione and the nuclear CT-DNA. The compound was characterized by melting point (m.p.) 119Sn Mössbauer ...
Source: Inorganica Chimica Acta - November 17, 2014 Category: Chemistry Source Type: research

Electrochemically controlled in-tube solid phase microextraction of naproxen from urine samples using an experimental design
Analyst, 2015, Advance ArticleDOI: 10.1039/C4AN01664E, PaperSeyyed Hamid Ahmadi, Ahmad Manbohi, Kourosh Tabar HeydarElectrochemically controlled in-tube SPME approach, which increased the sensitivity and decreased the extraction time, was reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - November 15, 2014 Category: Chemistry Authors: Seyyed Hamid Ahmadi Source Type: research

Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
Publication date: 5 December 2014 Source:Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 463 Author(s): R. Rojas , A.F. Jimenez-Kairuz , R.H. Manzo , C.E. Giacomelli This work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceed...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - November 14, 2014 Category: Chemistry Source Type: research

Naproxen Attenuates Sensitization of Depressive-Like Behavior and Fever during Maternal Separation
Publication date: Available online 14 November 2014 Source:Physiology & Behavior Author(s): Michael B. Hennessy , Nathan P. Stafford , Brittany Yusko-Osborne , Patricia A. Schiml , Evan D. Xanthos , Terrence Deak Early life stress can increase susceptibility for later development of depressive illness though a process thought to involve inflammatory mediators. Isolated guinea pig pups exhibit a passive, depressive-like behavioral response and fever that appear mediated by proinflammatory activity, and which sensitize with repeated separations. Treatment with an anti-inflammatory can attenuate the behavioral respo...
Source: Physiology and Behavior - November 14, 2014 Category: Physiology Source Type: research

Optic neuritis in juvenile idiopathic arthritis patient
In conclusion, a low prevalence of ON was observed in our JIA population. The absence of anti-AQP4 antibody and the normal brain MRI do not exclude the possibility of demyelinating disease associated with chronic arthritis. Therefore, rigorous follow up is required. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 7, 2014 Category: Rheumatology Source Type: research

Upgrading the performances of ultrafiltration membrane system coupled with activated sludge reactor by addition of biofilm supports for the treatment of hospital effluents
Publication date: 15 February 2015 Source:Chemical Engineering Journal, Volume 262 Author(s): Alrhmoun Mousaab , Carrion Claire , Casellas Magali , Dagot Christophe The biological treatment of an hospital effluent has been monitored during 150days in an activated sludge system followed by an ultrafiltration membrane (BBR-UF). After 75days, support media was added into the bioreactor to develop a biofilm and to compare process performances of the two reactor configurations: activated sludge (AS-UF) or biofilm biological reactor (BBR-UF). The removal efficiencies of (chemical oxygen demand) COD, (total suspended solids) TS...
Source: Chemical Engineering Journal - November 3, 2014 Category: Chemistry Source Type: research

Does ongoing general practitioner care in elderly patients help reduce the risk of unplanned hospitalization related to Beers potentially inappropriate medications?
ConclusionsIncreased requirement for ongoing GP contact in less healthy elderly people appears to help minimize their risk of unplanned hospitalization due to PIM‐related harm. GPs should continue to avoid Beers medications in older patients where possible, given their greater predisposition to medication exposure (including PIM) and adverse drug events. Nevertheless, close monitoring of elderly patients who need to use PIM should prove beneficial. Geriatr Gerontol Int 2014; ●●: ●●–●●. (Source: Geriatrics and Gerontology International)
Source: Geriatrics and Gerontology International - November 3, 2014 Category: Geriatrics Authors: Sylvie D Price, C D'Arcy J Holman, Frank M Sanfilippo, Jon D Emery Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Epitheloid Hemangioma Treated With Naproxen Sodium
We present a case of EH of the scrotum in a 14-year-old male patient that regressed after treatment with naproxen sodium. To the best of our knowledge, this represents the first reported case of scrotal EH regression following treatment with naproxen sodium.Level of Evidence: V (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - November 1, 2014 Category: Surgery Tags: Original Articles Source Type: research

Electrochemically controlled in-tube solid phase microextraction of naproxen from urine samples using experimental design
Analyst, 2014, Accepted ManuscriptDOI: 10.1039/C4AN01664E, PaperS. H. Ahmadi, Ahmad Manbohi, K. Heydar TabarA new in-tube solid phase microextraction approach named electrochemically controlled in-tube solid phase microextraction (EC in-tube SPME) has been reported. In this approach, which electrochemistry and in-tube SPME were combined,...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 29, 2014 Category: Chemistry Authors: S. H. Ahmadi Source Type: research

Occurrence of selected pharmaceuticals in the principal sewage treatment plants in Rome (Italy) and in the receiving surface waters.
Abstract This paper provides data on the occurrence of selected human pharmaceuticals (carbamazepine, clofibric acid, diclofenac, fenofibrate, fenoprofen, gemfibrozil, ibuprofen, ketoprofen, and naproxen) including steroid hormones (17β-estradiol, 17α-ethinylestradiol, and estrone) in influents/effluents to/from the four principal wastewater treatment plants (WWTPs) serving the city of Rome (Italy), in two different sampling campaigns. Target compounds were also analyzed in the receiving River Tiber and River Aniene. Analytical determination was carried out by LC-MS/MS after sample cleanup and concentration by of...
Source: Environmental Science and Pollution Research International - October 29, 2014 Category: Environmental Health Authors: Patrolecco L, Capri S, Ademollo N Tags: Environ Sci Pollut Res Int Source Type: research

Does Nonsurgical Treatment Improve Longitudinal Outcomes of Lateral Epicondylitis Over No Treatment? A Meta-analysis.
CONCLUSIONS: Pooled data from RCTs indicate a lack of intermediate- to long-term clinical benefit after nonsurgical treatment of lateral epicondylitis compared with observation only or placebo. LEVEL OF EVIDENCE: Level II, therapeutic study. PMID: 25352261 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - October 29, 2014 Category: Orthopaedics Authors: Sayegh ET, Strauch RJ Tags: Clin Orthop Relat Res Source Type: research

Cardiovascular Risk with Non-steroidal Anti-inflammatory Drugs: Clinical Implications
Abstract In February 2014, the US Food and Drug Administration (FDA) convened an advisory committee meeting to discuss the accumulated data relating to the cardiovascular risk of non-steroidal anti-inflammatory drugs (NSAIDs) and the potential implications on the class prescription labeling. The committee recommended, though not unanimously, that (1) the current data does not support the conclusion that naproxen has a lower risk of thrombotic events than other NSAIDs; (2) there is no latency period for the risk of cardiovascular thrombotic events; (3) there are some patient populations at increased risk for event...
Source: Drug Safety - October 23, 2014 Category: Drugs & Pharmacology Source Type: research

Prophylaxis for acute gout flares after initiation of urate-lowering therapy
This review summarizes evidence relating to prophylaxis for gout flares after the initiation of urate-lowering therapy (ULT). We searched MEDLINE via PubMed for articles published in English from 1963 to 2013 using MEsH terms covering all aspects of prophylaxis for flares. Dispersion of monosodium urate crystals during the initial phase of deposit dissolution with ULT exposes the patient to an increased rate of acute flares that could contribute to poor treatment adherence. Slow titration of ULT might decrease the risk of flares. According to the most recent international recommendation, the two first-line options for prop...
Source: Rheumatology - October 19, 2014 Category: Rheumatology Authors: Latourte, A., Bardin, T., Richette, P. Tags: Crystal Arthritis REVIEWS Source Type: research

Improvement of catalytic activity of lipase in the presence of calix[4]arene valeric acid or hydrazine derivative.
Abstract Sol-gel encapsulation is a simple but powerful method to enhance the enantioselectivity of lipase-catalyzed transformations in an isooctane/aqueous buffer solution. Candida rugosa lipase was encapsulated according to a sol-gel procedure in the presence and absence of calix[4]arene hydrazine or carboxylic acid derivatives with Fe3O4 magnetic nanoparticles as an additive. The activity of the encapsulated lipases was evaluated for the enantioselective hydrolysis of racemic Naproxen methyl ester and the hydrolysis of p-Nitrophenylpalmitate. The results indicate that the encapsulated lipase without calix[4]aren...
Source: Bioprocess and Biosystems Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Akoz E, Sayin S, Kaplan S, Yilmaz M Tags: Bioprocess Biosyst Eng Source Type: research

Breastfeeding and migraine drugs
Conclusions According to our review, the majority of the revised AMDs were assessed to be compatible with breastfeeding. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 16, 2014 Category: Drugs & Pharmacology Source Type: research

Development of a solid self-microemulsifying drug delivery system (SMEDDS) for solubility enhancement of naproxen
Drug Development and Industrial Pharmacy, Ahead of Print. (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - October 13, 2014 Category: Drugs & Pharmacology Tags: article Source Type: research

A quality by design (QbD) case study on enteric-coated pellets: Screening of critical variables and establishment of design space at laboratory scale
Publication date: Available online 28 August 2014 Source:Asian Journal of Pharmaceutical Sciences Author(s): Shuling Kan , Jing Lu , Jianping Liu , Junlin Wang , Yi Zhao The study aims to prepare naproxen enteric-coated pellets (NAP-ECPs) by fluid-bed coating using QbD principle. Risk assessment was firstly performed by using failure mode and effect analysis (FMEA) methodology. A Plackett–Burman design was then used for assessment of the most important variables affecting enteric-coated pellets characteristics. A Box–Behnken design was subsequently used for investigating the main, interactive, and quadratic effects o...
Source: Asian Journal of Pharmaceutical Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research

Hydrogen Sulfide Protects Against NSAID‐Enteropathy Through Modulation of Bile and the Microbiota
Conclusions and implicationsHydrogen sulfide protects against NSAID‐enteropathy in rats, in part reducing the cytotoxicity of bile and preventing NSAID‐induced dysbiosis. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - October 8, 2014 Category: Drugs & Pharmacology Authors: Rory W Blackler, Jean‐Paul Motta, Anna Manko, Matthew Workentine, Premysl Bercik, Michael G Surette, John L Wallace Tags: Research Paper Source Type: research

Migraine-Related Healthcare Resource Use and Costs for Subjects Prescribed Fixed-Dose Combination Sumatriptan/Naproxen Sodium vs. Single-Entity Oral Triptans in a Managed Care Population in the USA
Conclusion Study results suggest similar healthcare resource use patterns and associated costs when comparing S/NS and SOT across a triptan-naïve and triptan-experienced population. While the current study focuses on direct medical costs, future studies should extend beyond such a perspective to explore functional status, productivity, and health-related quality of life and satisfaction, attributes not captured in administrative claims data, but nonetheless important treatment goals. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - October 7, 2014 Category: Health Management Source Type: research

Efficacy and Safety of Intravenous Tanezumab for the Symptomatic Treatment of Osteoarthritis: 2 Randomized Controlled Trials versus Naproxen.
CONCLUSION: Tanezumab provides efficacious treatment of knee or hip OA and may have therapeutic utility in patients with OA who experience inadequate analgesia with nonsteroidal antiinflammatory drugs. PMID: 25274899 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2014 Category: Rheumatology Authors: Ekman EF, Gimbel JS, Bello AE, Smith MD, Keller DS, Annis KM, Brown MT, West CR, Verburg KM Tags: J Rheumatol Source Type: research

Naproxen Effects on Brain Response to Painful Pressure Stimulation in Patients with Knee Osteoarthritis: A Double-blind, Randomized, Placebo-controlled, Single-dose Study.
CONCLUSION: Naproxen effectively reduces pain-related brain responses involving different regions and the attenuation is related to subjective pain changes. Our current work yields further support to the utility of fMRI to objectify the acute analgesic effects of a single naproxen dose in patients affected by knee OA. The trial was registered at the EuropeanClinicalTrials Database, "EudraCT Number 2008-004501-33". PMID: 25274897 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2014 Category: Rheumatology Authors: Giménez M, Pujol J, Ali Z, López-Solà M, Contreras-Rodríguez O, Deus J, Ortiz H, Soriano-Mas C, Llorente-Onaindia J, Monfort J Tags: J Rheumatol Source Type: research

Recurrent angioedema after naproxen use in a patient stabilized with losartan
Allergic reactions that result from concomitant drug use are understood yet potentially overlooked risk factors for angioedema. Nonsteroidal anti-inflammatory drugs (NSAIDs) in particular have been noted to trigger angioedema in patients with associated risk who are stabilized with other agents.1,2 Previous reports have described cases of angioedema after NSAID administration in patients stabilized on angiotensin-converting enzyme (ACE) inhibitors; however, detailed reports in patients receiving angiotensin receptor blockers (ARBs) are lacking. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - October 1, 2014 Category: Allergy & Immunology Authors: Jineane V. Venci, Joel A. Shamaskin Tags: Letter Source Type: research

Recurrent angioedema after naproxen use in a patient stabilized with losartan.
PMID: 25282368 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - October 1, 2014 Category: Allergy & Immunology Authors: Venci JV, Shamaskin JA Tags: Ann Allergy Asthma Immunol Source Type: research

Abstract 2126: PIK3CA mutation status is not involved in the response of nonsteroidal anti-inflammatory drugs in colorectal cancer cell lines
Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown a chemopreventive effect for colorectal cancer (CRC) in many epidemiological and large scale population studies. Moreover, regular use of NSAIDs has been recently associated with a reduction in the recurrence rate of CRC in patients previously diagnosed with colorectal tumors harboring PIK3CA mutations in two different retrospective analyses of large clinical cohorts. However, the mechanism by which PIK3CA mutations interacts with the mechanism of action of NSAIDs remains elusive. Our aim was to investigate the contribution of the most common alterations detected in ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Borras-Flores, E., Calhoun, K., Bhatia, G., Wu, H., Vilar-Sanchez, E. Tags: Prevention Research Source Type: research

Esterase-activated release of naproxen from supramolecular nanofibres
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C4CC06340F, CommunicationMartin Conda-Sheridan, Sungsoo S. Lee, Adam T. Preslar, Samuel I. StuppThe esterase-dependent release of naproxen from a self-assembled peptide nanomaterial modulates an anti-inflammatory pathway.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - September 25, 2014 Category: Chemistry Authors: Martin Conda-Sheridan Source Type: research

Prevention and Treatment of NSAID Gastropathy
Opinion statement Nonsteroidal anti-inflammatory drug (NSAID) treatment will be necessary as part of our therapeutic armamentarium for many years to come. Therefore, safe prescription is mandatory in order to prevent adverse events. In the last two decades, new strategies and new drugs have been developed to reduce NSAID-associated upper gastrointestinal (GI) adverse events. Although the implementation of guidelines into clinical practice takes time, several studies have shown a recent and profound decrease in hospitalizations due to upper GI complications, which has been linked to widespread use of proton pump in...
Source: Current Treatment Options in Gastroenterology - September 11, 2014 Category: Gastroenterology Source Type: research

Molecular interactions between some non-steroidal anti-inflammatory drugs (NSAID׳s) and bovine (BSA) or human (HSA) serum albumin estimated by means of isothermal titration calorimetry (ITC) and frontal analysis capillary electrophoresis (FA/CE).
Abstract The interactions between some non-steroidal anti-inflammatory drugs, NSAIDs, (naproxen, ibuprofen and flurbiprofen) and bovine (BSA) or human (HSA) serum albumin have been examined by means of two complementary techniques, isothermal titration calorimetry (ITC) and frontal analysis/capillary electrophoresis (FA/CE). It can be concluded that ITC is able to measure with high precision the strongest drug-albumin interactions but the higher order interactions can be better determined by means of FA/CE. Then, the combination of both techniques leads to a complete evaluation of the binding profiles between the s...
Source: Talanta - September 1, 2014 Category: Chemistry Authors: Ràfols C, Zarza S, Bosch E Tags: Talanta Source Type: research

Purity Analysis of the Pharmaceuticals Naproxen and Propranolol: A Guided-Inquiry Laboratory Experiment in the Analytical Chemistry Laboratory
Journal of Chemical EducationDOI: 10.1021/ed500282h (Source: Journal of Chemical Education)
Source: Journal of Chemical Education - August 12, 2014 Category: Chemistry Authors: Sayo O. Fakayode Source Type: research

Cardiovascular Pharmacogenetics of Anti-Thrombotic Agents and Non-Steroidal Anti-Inflammatory Drugs.
Abstract The use of antithrombotic agents, particularly antiplatelet drugs like aspirin and clopidogrel, has been instrumental in decreasing the risk for adverse cardiovascular events across a wide range of patients. However, despite the established benefits, the use of these medications remains suboptimal. There is a high degree of inter-individual variation in response to these treatments, whereby patients experience occlusive thromboembolic events, in spite of maintaining an appropriate treatment regimen. This has lead to the notion of antithrombotic "resistance" or "poor responders", which has been a growing co...
Source: Current Molecular Medicine - August 11, 2014 Category: Molecular Biology Authors: Stitham J, Vanichakarn P, Ying L, Hwa J Tags: Curr Mol Med Source Type: research

The presence of the top prescribed pharmaceuticals in treated sewage effluents and receiving waters in Southwest Nova Scotia, Canada.
Abstract From a list of the top prescribed drugs in Canada, 11 pharmaceuticals and two metabolites were selected for study in municipal sewage treatment plant effluents and receiving waters. Wastewater samples were collected from 16 wastewater treatment plants across Southwest Nova Scotia including the Annapolis Valley, South Shore, and Metropolitan Halifax. Samples were also collected between 100 and 200 m downstream of effluent outflows. Seven pharmaceuticals were found above μg/L levels with their highest concentrations as follows: metformin (10.6 μg/L), acetaminophen (28.9 μg/L), paraxanthine (18.2 μg/L...
Source: Environmental Science and Pollution Research International - August 8, 2014 Category: Environmental Health Authors: Ghoshdastidar AJ, Fox S, Tong AZ Tags: Environ Sci Pollut Res Int Source Type: research

A novel naproxen derivative capable of displaying anti-cancer and anti-migratory properties against human breast cancer cells
Conclusion: In this study we report that a naproxen-derivative (4) has powerful anti-inflammatory and anti-tumor properties as it induces appreciable amount of apoptosis in breast cancer cell line, and can also delay migration of cancer cells (MDA-MB-231) which would in turn delay cancer cell invasion and formation of secondary tumours in primary breast cancer patients. Thus, we propose that 4 is worthy of further investigation due to its potential as a therapeutic agent in anti-tumor treatment regimen. (Source: BMC Cancer)
Source: BMC Cancer - August 7, 2014 Category: Cancer & Oncology Authors: Jolly DebJoydeb MajumderSankar BhattacharyyaSiddhartha Sankar Jana Source Type: research

Microbial community structure and pharmaceuticals and personal care products removal in a membrane bioreactor seeded with aerobic granular sludge.
Abstract A process involving the use of membrane bioreactor seeded with aerobic granular sludge (GMBR) was applied to the treatment of sewage containing pharmaceuticals and personal care products (PPCPs). The removal effects of five kinds of medicines in the reactor were investigated, and the microbial communities were constructed by polymerase chain reaction and denaturing gradient gel electrophoresis. We also determined the effects of different sludge retention and hydraulic retention times (SRT and HRT, respectively) and influent organic loading on GMBR's efficiency in processing sewage containing PPCPs. The rem...
Source: Applied Microbiology and Biotechnology - August 7, 2014 Category: Microbiology Authors: Xia Z, Xiao-Chun W, Zhong-Lin C, Hao X, Qing-Fang Z Tags: Appl Microbiol Biotechnol Source Type: research

Comparative evaluation of cardiovascular outcomes in patients with osteoarthritis and rheumatoid arthritis on recommended doses of nonsteroidal anti-inflammatory drugs
Conclusion: From the analysis conducted, it appears that the risk for cardiovascular events in arthritis patients on licensed doses of NSAIDs varies considerably and is likely to depend on the individual compound. (Source: Therapeutic Advances in Musculoskeletal Disease)
Source: Therapeutic Advances in Musculoskeletal Disease - August 4, 2014 Category: Orthopaedics Authors: Fabule, J., Adebajo, A. Tags: Original Research Source Type: research

Oral administration of whole dihomo-γ-linolenic acid-producing Saccharomyces cerevisiae suppresses cutaneous inflammatory responses induced by croton oil application in mice.
In this study, we investigated the efficacy of oral intake of heat-killed whole DGLA-producing yeast cells in the absence of lipid purification on cutaneous inflammation. Topical application of croton oil to mouse ears induces ear swelling in parallel with the increased production of chemokines and accumulation of infiltrating cells into the skin sites. These inflammatory reactions were significantly suppressed in a dose-dependent manner by oral intake of the DGLA-producing yeast cells for only 7 days. This suppression was not observed by the intake of the γ-linolenic acid-producing (C18:3n-6, an immediate precursor of D...
Source: Applied Microbiology and Biotechnology - July 29, 2014 Category: Microbiology Authors: Watanabe N, Masubuchi D, Itoh M, Teradu S, Yazawa H, Uemura H Tags: Appl Microbiol Biotechnol Source Type: research