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Prophylaxis for acute gout flares after initiation of urate-lowering therapy
This review summarizes evidence relating to prophylaxis for gout flares after the initiation of urate-lowering therapy (ULT). We searched MEDLINE via PubMed for articles published in English from 1963 to 2013 using MEsH terms covering all aspects of prophylaxis for flares. Dispersion of monosodium urate crystals during the initial phase of deposit dissolution with ULT exposes the patient to an increased rate of acute flares that could contribute to poor treatment adherence. Slow titration of ULT might decrease the risk of flares. According to the most recent international recommendation, the two first-line options for prop...
Source: Rheumatology - October 19, 2014 Category: Rheumatology Authors: Latourte, A., Bardin, T., Richette, P. Tags: Crystal Arthritis REVIEWS Source Type: research

Improvement of catalytic activity of lipase in the presence of calix[4]arene valeric acid or hydrazine derivative.
Abstract Sol-gel encapsulation is a simple but powerful method to enhance the enantioselectivity of lipase-catalyzed transformations in an isooctane/aqueous buffer solution. Candida rugosa lipase was encapsulated according to a sol-gel procedure in the presence and absence of calix[4]arene hydrazine or carboxylic acid derivatives with Fe3O4 magnetic nanoparticles as an additive. The activity of the encapsulated lipases was evaluated for the enantioselective hydrolysis of racemic Naproxen methyl ester and the hydrolysis of p-Nitrophenylpalmitate. The results indicate that the encapsulated lipase without calix[4]aren...
Source: Bioprocess and Biosystems Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Akoz E, Sayin S, Kaplan S, Yilmaz M Tags: Bioprocess Biosyst Eng Source Type: research

Breastfeeding and migraine drugs
Conclusions According to our review, the majority of the revised AMDs were assessed to be compatible with breastfeeding. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 16, 2014 Category: Drugs & Pharmacology Source Type: research

Hydrogen Sulfide Protects Against NSAID‐Enteropathy Through Modulation of Bile and the Microbiota
Conclusions and implicationsHydrogen sulfide protects against NSAID‐enteropathy in rats, in part reducing the cytotoxicity of bile and preventing NSAID‐induced dysbiosis. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - October 8, 2014 Category: Drugs & Pharmacology Authors: Rory W Blackler, Jean‐Paul Motta, Anna Manko, Matthew Workentine, Premysl Bercik, Michael G Surette, John L Wallace Tags: Research Paper Source Type: research

Migraine-Related Healthcare Resource Use and Costs for Subjects Prescribed Fixed-Dose Combination Sumatriptan/Naproxen Sodium vs. Single-Entity Oral Triptans in a Managed Care Population in the USA
Conclusion Study results suggest similar healthcare resource use patterns and associated costs when comparing S/NS and SOT across a triptan-naïve and triptan-experienced population. While the current study focuses on direct medical costs, future studies should extend beyond such a perspective to explore functional status, productivity, and health-related quality of life and satisfaction, attributes not captured in administrative claims data, but nonetheless important treatment goals. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - October 7, 2014 Category: Health Management Source Type: research

Recurrent angioedema after naproxen use in a patient stabilized with losartan.
PMID: 25282368 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - October 1, 2014 Category: Allergy & Immunology Authors: Venci JV, Shamaskin JA Tags: Ann Allergy Asthma Immunol Source Type: research

Naproxen Effects on Brain Response to Painful Pressure Stimulation in Patients with Knee Osteoarthritis: A Double-blind, Randomized, Placebo-controlled, Single-dose Study.
CONCLUSION: Naproxen effectively reduces pain-related brain responses involving different regions and the attenuation is related to subjective pain changes. Our current work yields further support to the utility of fMRI to objectify the acute analgesic effects of a single naproxen dose in patients affected by knee OA. The trial was registered at the EuropeanClinicalTrials Database, "EudraCT Number 2008-004501-33". PMID: 25274897 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2014 Category: Rheumatology Authors: Giménez M, Pujol J, Ali Z, López-Solà M, Contreras-Rodríguez O, Deus J, Ortiz H, Soriano-Mas C, Llorente-Onaindia J, Monfort J Tags: J Rheumatol Source Type: research

Efficacy and Safety of Intravenous Tanezumab for the Symptomatic Treatment of Osteoarthritis: 2 Randomized Controlled Trials versus Naproxen.
CONCLUSION: Tanezumab provides efficacious treatment of knee or hip OA and may have therapeutic utility in patients with OA who experience inadequate analgesia with nonsteroidal antiinflammatory drugs. PMID: 25274899 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2014 Category: Rheumatology Authors: Ekman EF, Gimbel JS, Bello AE, Smith MD, Keller DS, Annis KM, Brown MT, West CR, Verburg KM Tags: J Rheumatol Source Type: research

Esterase-activated release of naproxen from supramolecular nanofibres
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C4CC06340F, CommunicationMartin Conda-Sheridan, Sungsoo S. Lee, Adam T. Preslar, Samuel I. StuppThe esterase-dependent release of naproxen from a self-assembled peptide nanomaterial modulates an anti-inflammatory pathway.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - September 25, 2014 Category: Chemistry Authors: Martin Conda-Sheridan Source Type: research

Prevention and Treatment of NSAID Gastropathy
Opinion statement Nonsteroidal anti-inflammatory drug (NSAID) treatment will be necessary as part of our therapeutic armamentarium for many years to come. Therefore, safe prescription is mandatory in order to prevent adverse events. In the last two decades, new strategies and new drugs have been developed to reduce NSAID-associated upper gastrointestinal (GI) adverse events. Although the implementation of guidelines into clinical practice takes time, several studies have shown a recent and profound decrease in hospitalizations due to upper GI complications, which has been linked to widespread use of proton pump in...
Source: Current Treatment Options in Gastroenterology - September 11, 2014 Category: Gastroenterology Source Type: research

Molecular interactions between some non-steroidal anti-inflammatory drugs (NSAID׳s) and bovine (BSA) or human (HSA) serum albumin estimated by means of isothermal titration calorimetry (ITC) and frontal analysis capillary electrophoresis (FA/CE).
Abstract The interactions between some non-steroidal anti-inflammatory drugs, NSAIDs, (naproxen, ibuprofen and flurbiprofen) and bovine (BSA) or human (HSA) serum albumin have been examined by means of two complementary techniques, isothermal titration calorimetry (ITC) and frontal analysis/capillary electrophoresis (FA/CE). It can be concluded that ITC is able to measure with high precision the strongest drug-albumin interactions but the higher order interactions can be better determined by means of FA/CE. Then, the combination of both techniques leads to a complete evaluation of the binding profiles between the s...
Source: Talanta - September 1, 2014 Category: Chemistry Authors: Ràfols C, Zarza S, Bosch E Tags: Talanta Source Type: research

Purity Analysis of the Pharmaceuticals Naproxen and Propranolol: A Guided-Inquiry Laboratory Experiment in the Analytical Chemistry Laboratory
Journal of Chemical EducationDOI: 10.1021/ed500282h (Source: Journal of Chemical Education)
Source: Journal of Chemical Education - August 12, 2014 Category: Chemistry Authors: Sayo O. Fakayode Source Type: research

Cardiovascular Pharmacogenetics of Anti-Thrombotic Agents and Non-Steroidal Anti-Inflammatory Drugs.
Abstract The use of antithrombotic agents, particularly antiplatelet drugs like aspirin and clopidogrel, has been instrumental in decreasing the risk for adverse cardiovascular events across a wide range of patients. However, despite the established benefits, the use of these medications remains suboptimal. There is a high degree of inter-individual variation in response to these treatments, whereby patients experience occlusive thromboembolic events, in spite of maintaining an appropriate treatment regimen. This has lead to the notion of antithrombotic "resistance" or "poor responders", which has been a growing co...
Source: Current Molecular Medicine - August 11, 2014 Category: Molecular Biology Authors: Stitham J, Vanichakarn P, Ying L, Hwa J Tags: Curr Mol Med Source Type: research

The presence of the top prescribed pharmaceuticals in treated sewage effluents and receiving waters in Southwest Nova Scotia, Canada.
Abstract From a list of the top prescribed drugs in Canada, 11 pharmaceuticals and two metabolites were selected for study in municipal sewage treatment plant effluents and receiving waters. Wastewater samples were collected from 16 wastewater treatment plants across Southwest Nova Scotia including the Annapolis Valley, South Shore, and Metropolitan Halifax. Samples were also collected between 100 and 200 m downstream of effluent outflows. Seven pharmaceuticals were found above μg/L levels with their highest concentrations as follows: metformin (10.6 μg/L), acetaminophen (28.9 μg/L), paraxanthine (18.2 μg/L...
Source: Environmental Science and Pollution Research International - August 8, 2014 Category: Environmental Health Authors: Ghoshdastidar AJ, Fox S, Tong AZ Tags: Environ Sci Pollut Res Int Source Type: research

Microbial community structure and pharmaceuticals and personal care products removal in a membrane bioreactor seeded with aerobic granular sludge.
Abstract A process involving the use of membrane bioreactor seeded with aerobic granular sludge (GMBR) was applied to the treatment of sewage containing pharmaceuticals and personal care products (PPCPs). The removal effects of five kinds of medicines in the reactor were investigated, and the microbial communities were constructed by polymerase chain reaction and denaturing gradient gel electrophoresis. We also determined the effects of different sludge retention and hydraulic retention times (SRT and HRT, respectively) and influent organic loading on GMBR's efficiency in processing sewage containing PPCPs. The rem...
Source: Applied Microbiology and Biotechnology - August 7, 2014 Category: Microbiology Authors: Xia Z, Xiao-Chun W, Zhong-Lin C, Hao X, Qing-Fang Z Tags: Appl Microbiol Biotechnol Source Type: research

A novel naproxen derivative capable of displaying anti-cancer and anti-migratory properties against human breast cancer cells
Conclusion: In this study we report that a naproxen-derivative (4) has powerful anti-inflammatory and anti-tumor properties as it induces appreciable amount of apoptosis in breast cancer cell line, and can also delay migration of cancer cells (MDA-MB-231) which would in turn delay cancer cell invasion and formation of secondary tumours in primary breast cancer patients. Thus, we propose that 4 is worthy of further investigation due to its potential as a therapeutic agent in anti-tumor treatment regimen. (Source: BMC Cancer)
Source: BMC Cancer - August 7, 2014 Category: Cancer & Oncology Authors: Jolly DebJoydeb MajumderSankar BhattacharyyaSiddhartha Sankar Jana Source Type: research

Oral administration of whole dihomo-γ-linolenic acid-producing Saccharomyces cerevisiae suppresses cutaneous inflammatory responses induced by croton oil application in mice.
In this study, we investigated the efficacy of oral intake of heat-killed whole DGLA-producing yeast cells in the absence of lipid purification on cutaneous inflammation. Topical application of croton oil to mouse ears induces ear swelling in parallel with the increased production of chemokines and accumulation of infiltrating cells into the skin sites. These inflammatory reactions were significantly suppressed in a dose-dependent manner by oral intake of the DGLA-producing yeast cells for only 7 days. This suppression was not observed by the intake of the γ-linolenic acid-producing (C18:3n-6, an immediate precursor of D...
Source: Applied Microbiology and Biotechnology - July 29, 2014 Category: Microbiology Authors: Watanabe N, Masubuchi D, Itoh M, Teradu S, Yazawa H, Uemura H Tags: Appl Microbiol Biotechnol Source Type: research

PPCPs removal by aerobic granular sludge membrane bioreactor.
Abstract An aerobic granular sludge membrane bioreactor (GMBR) was applied to the treatment of pharmaceutical and personal care products (PPCPs) wastewater. The influence of granular sludge on five antibiotic and antiphlogistic PPCPs wastewater and the removal effect of methyl alcohol and conventional organic matter were investigated while constantly reducing the density of inflow organic matter. The results showed that the sludge granulation process in the system was rapid but unstable, and that the system exhibits a dissolution-reunion dynamic equilibrium. The reactor demonstrated varying removal effects of PPCPs...
Source: Applied Microbiology and Biotechnology - July 20, 2014 Category: Microbiology Authors: Zhao X, Chen ZL, Wang XC, Shen JM, Xu H Tags: Appl Microbiol Biotechnol Source Type: research

Druggists and pharmacists as gatekeepers: Sales routines and compliance with sales protocols for over-the-counter naproxen 275mg medicines in the Netherlands
Over the last decades, the sales of medicines has largely been shifted from prescription drugs to over-the-counter (OTC), non-prescription medicines. In 2008, for the first time ever, the growth in the sales OTC medicines exceeded the sales of prescription medicines [1]. Instead of going to the doctor for a specific medicine, more and more medicines are available without a prescription in a pharmacy or drugstore. On the one hand this eases the pressure on doctors and the health care system, but on the other hand people may abuse medicines more easily. (Source: Health Policy)
Source: Health Policy - July 18, 2014 Category: Health Management Authors: Joris J. van Hoof, Michel H.G. Cents, Nicole M.J. Megens, Sijbrand J. van der Tang Source Type: research

Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study.
CONCLUSIONS: Treatment for 1 to 3 years with naproxen or celecoxib did not protect against cognitive decline in older adults with a family history of AD. PMID: 25022541 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 17, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Double‐injection capillary electrophoresis for the identification of analytes
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - July 17, 2014 Category: Biochemistry Authors: Ahmad Amini Tags: Research Article Source Type: research

Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules
Conclusions: These results indicate that Npx can affect gene expression during osteogenic differentiation of MSCs, and downregulate mineral deposition in the extracellular matrix through IHH signaling. Therefore, Npx could affect MSC-mediated repair of subchondral bone in OA patients. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 17, 2014 Category: Rheumatology Authors: Omar SalemHong WangAbdulrahman AlaseemOvidiu CiobanuInsaf HadjabRahul GawriJohn AntoniouFackson Mwale Source Type: research

[Current state of knowledge and developments in the prophylaxis and acute treatment of migraine.]
Abstract For the acute treatment of the headache phase of a migraine attack, a variety of different pharmacotherapeutic treatment options exist. These range from nonspecifically acting non-opioid analgesics (e.g., paracetamol) and nonsteroidal anti-inflammatory substances (e.g., acetylsalicylic acid, ibuprofen, naproxen, diclofenac) to agents specifically interfering with the serotonin system (ergot alkaloids such as ergotamine and its derivatives, triptans). In patients with significant emesis co-occurring during an attack, additional antiemetics such as metoclopramide or domperidone may be administered. In migrai...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - July 16, 2014 Category: Global & Universal Authors: Schriever J, Bühlen M, Broich K Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

Nonsteroidal Anti-Inflammatory Drugs and Cardiovascular Outcomes in Women: Results From the Women's Health Initiative [Original Articles]
Conclusions— Regular use of selective cox-2 inhibitors and nonselective NSAIDs with cox-2>cox-1 inhibition showed a modestly increased hazard for cardiovascular events. Nonselective agents with cox-1>cox-2 inhibition were not associated with increased cardiovascular risk. Clinical Trial Registration— URL: www.clinicaltrials.gov. Unique identifier: NCT00000611. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - July 15, 2014 Category: Cardiology Authors: Bavry, A. A., Thomas, F., Allison, M., Johnson, K. C., Howard, B. V., Hlatky, M., Manson, J. E., Limacher, M. C. Tags: Risk Factors Original Articles Source Type: research

Capability of the natural microbial community in a river water ecosystem to degrade the drug naproxen.
This study shows that with the concentration studied, naproxen was degraded by the natural microbial populations collected from a river chronically contaminated by this pharmaceutical. PMID: 25012207 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - July 12, 2014 Category: Environmental Health Authors: Grenni P, Patrolecco L, Ademollo N, Di Lenola M, Barra Caracciolo A Tags: Environ Sci Pollut Res Int Source Type: research

Cholestatic hepatic injury associated with vismodegib, aspirin, and naproxen use: a case study and review of vismodegib safety
ConclusionsHerein, we describe a potential serious adverse effect associated with vismodegib use. Whether the illness is directly attributable to the medication or the result of drug‐drug interactions between vismodegib and NSAIDs, practitioners should be aware of the possibility of hepatic injury in patients on vismodegib. Furthermore, patients need to be informed of the potential risks of vismodegib and should be monitored closely to ensure that life‐threatening complications of treatment are avoided. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - July 11, 2014 Category: Dermatology Authors: Mark M. Ash, Puneet S. Jolly Tags: Pharmacology and Therapeutics Source Type: research

Combination of tocolytic agents for inhibiting preterm labour.
CONCLUSIONS: It is unclear whether a combination of tocolytic drugs for preterm labour is more advantageous for women and/or newborns due to a lack of large, well-designed trials including the outcomes of interest. There are no trials of combination regimens using widely used tocolytic agents, such as calcium channel blockers (nifedipine) and/or oxytocin receptor antagonists (atosiban). Further trials are needed before specific conclusions on use of combination tocolytic therapy for preterm labour can be made. PMID: 25010869 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - July 11, 2014 Category: Journals (General) Authors: Vogel JP, Nardin JM, Dowswell T, West HM, Oladapo OT Tags: Cochrane Database Syst Rev Source Type: research

Does the use of antipyretics prolong the duration of fever or illness?
Review scope Studies were selected which compared the use of antipyretics with no antipyretics in children with acute febrile infectious illness. Outcomes included author-defined time to fever resolution, and infection-specific indicators of disease resolution. Review methods Medline and Embase (to November 2012) were searched for randomised controlled trials (RCTs) and quasi RCTs. Language restrictions were not specified. Quality of studies was assessed using the Cochrane risk of bias tool. Reference lists and Google Scholar were hand searched. Screening and searching was performed by two authors independently. Six studie...
Source: Archives of Disease in Childhood - Education and Practice - July 11, 2014 Category: Pediatrics Authors: Williams, C., Roland, D. Tags: Clinical trials (epidemiology), TB and other respiratory infections, Travel medicine, Tropical medicine (infectious diseases), Child health, Infant health, Screening (epidemiology), Screening (public health) Picket Source Type: research

Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study
We report here results describing trajectories of cognitive evaluation test scores. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 8, 2014 Category: Geriatrics Authors: ADAPT-FS Research Group Source Type: research

Fast ibuprofen, ketoprofen and naproxen simultaneous determination in human serum for clinical toxicology by GC-FID.
CONCLUSION: The entire sample preparation procedure is completed within 5minutes and the quantitative results are available within 35min. The method was successfully applied to quantify the selected compounds in serum of patients from emergency units. PMID: 25003797 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - July 5, 2014 Category: Biochemistry Authors: Hložek T, Bursová M, Cabala R Tags: Clin Biochem Source Type: research

Enhanced catalysis and enantioselective resolution of racemic naproxen methyl ester by lipase encapsulated within iron oxide nanoparticles coated with calix[8]arene valeric acid complexes
In this study, two types of nanoparticles have been driven as additives for the encapsulation of Candida rugosa lipase via the sol-gel method. In one case, the nanoparticles were covalently...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - July 3, 2014 Category: Molecular Biology Authors: Mustafa Yilmaz Source Type: research

Transformation and removal pathways of four common PPCP/EDCs in soil.
This study examined four PPCP/EDCs (bisphenol A, diclofenac, naproxen, and 4-nonylphenol) in soil by using (14)C-labeling and analyzing mineralization, extractable residue, bound residue, and formation of transformation products. At the end of 112 d of incubation, the majority of (14)C-naproxen and (14)C-diclofenac was mineralized to (14)CO2, while a majority of (14)C-bisphenol A and (14)Cnonylphenol was converted to bound residue. After 112 d, the estimated half-lives of the parent compounds were only 1.4-5.4 d. However a variety of transformation products were found and several for bisphenol A and diclofenac were iden...
Source: Environmental Pollution - July 2, 2014 Category: Environmental Health Authors: Dodgen LK, Li J, Wu X, Lu Z, Gan JJ Tags: Environ Pollut Source Type: research

Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles: an experimental comparative rat model.
CONCLUSION: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle. PMID: 24954342 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 28, 2014 Category: Universities & Medical Training Authors: Chin HY, Changchien E, Lin MF, Chiang CH, Wang CJ Tags: Yonsei Med J Source Type: research

Assessment of drug entrapment within liposomes using photophysical probes.
Abstract The photophysical and photochemical behavior of (R)-cinacalcet (CIN) and (S)-naproxen (NPX) entrapped within liposomes has been studied. For this purpose, liposome encapsulated drugs have been prepared through thin layer evaporation and characterized by transmission electron microscopy, cryoscopy scanning electron microscopy and dynamic light scattering. Steady state and time-resolved fluorescence experiments showed similar spectra, emission quantum yields, singlet energies and lifetimes for the selected drugs, outside and inside liposomes. By contrast, laser flash photolysis experiments revealed an import...
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 25, 2014 Category: Drugs & Pharmacology Authors: Oliverio F, Nuin E, Andreu I, Ragno G, Miranda MA Tags: Eur J Pharm Biopharm Source Type: research

Neutrophil migration towards C5a and CXCL8 is prevented by non‐steroidal anti‐inflammatory drugs via inhibition of different pathways
Conclusion and ImplicationsTreatment with NSAIDs reduced C5a‐ and CXCL8‐induced neutrophil migration and F‐actin polymerization via different mechanisms. Inhibition by ibuprofen was associated with integrin down‐regulation, while naproxen and oxaprozin blocked the PI3K/Akt pathway. Both NSAID actions were independent of COX inhibition and PGE2 release. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - June 25, 2014 Category: Drugs & Pharmacology Authors: Maria Bertolotto, Paola Contini, Luciano Ottonello, Aldo Pende, Franco Dallegri, Fabrizio Montecucco Tags: RESEARCH PAPER Source Type: research

A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain.
CONCLUSIONS: The addition of insomnia-specific therapy to a standardized naproxen pain regimen significantly improves sleep, pain, and depression in patients with chronic low back pain (LBP). The findings indicate the importance of administering both sleep and pain-directed therapies to patients with LBP in clinical practice and provide strong evidence that improving sleep disturbance may improve pain. TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT00365976. CITATION: Goforth HW, Preud'homme XA, Krystal AD. A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in p...
Source: Pain Physician - June 7, 2014 Category: Anesthesiology Authors: Goforth HW, Preud'homme XA, Krystal AD Tags: Sleep Source Type: research

Liquid chromatographic enantioseparation of (RS)-mexiletine and (RS)-fluoxetine using chiral derivatizing reagents synthesized with (S)-naproxen moiety.
Abstract Enantiomeric separation of racemic mexiletine and fluoxetine was achieved using three chiral derivatizing reagents (CDRs) based on (S)-naproxen. Diastereomers were synthesized by reaction of mexiletine or fluoxetine with the CDRs and were separated on a C18 column under reversed-phase conditions using a binary mixture of acetonitrile and triethylammonium phosphate/water, with UV detection at 230 and 226 nm. The results obtained for enantioseparation of the two drugs using the three CDRs were compiled and compared. The conditions for derivatization and chromatographic separation were optimized. The method...
Source: Biomedical Chromatography : BMC - May 31, 2014 Category: Biomedical Science Authors: Batra S, Bhushan R Tags: Biomed Chromatogr Source Type: research

A Randomized, Double-Blind, Placebo-Controlled Trial of Eszopiclone for the Treatment of Insomnia in Patients with Chronic Low Back Pain
Conclusions:The addition of insomnia-specific therapy to a standardized naproxen pain regimen significantly improves sleep, pain, and depression in patients with chronic low back pain (LBP). The findings indicate the importance of administering both sleep and pain-directed therapies to patients with LBP in clinical practice and provide strong evidence that improving sleep disturbance may improve pain.Trial Registration:clinicaltrials.gov identifier: NCT00365976Citation:Goforth HW, Preud'homme XA, Krystal AD. A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with c...
Source: Sleep - May 30, 2014 Category: Sleep Medicine Source Type: research

The Effect of NSAID Prophylaxis and Operative Variables on Heterotopic Ossification After Hip Arthroscopy
Conclusion: Routine NSAID prophylaxis reduces but does not eliminate the incidence of HO in patients undergoing hip arthroscopy. Heterotopic ossification was more likely to develop in patients undergoing acetabuloplasty along with osteochondroplasty and in those who did not receive prophylactic postoperative NSAIDs. Side effects from the investigated NSAID regimen can be serious and should be weighed against the potential benefits in preventing the formation of HO. (Source: The American Journal of Sports Medicine)
Source: The American Journal of Sports Medicine - May 30, 2014 Category: Sports Medicine Authors: Beckmann, J. T., Wylie, J. D., Kapron, A. L., Hanson, J. A., Maak, T. G., Aoki, S. K. Tags: Hip/Pelvis/Thigh, Hip, femoroactabular impingement, Hip arthroscopy, NSAIDS Hip and Thigh Source Type: research

Cigarette smoke induces alterations in the drug binding properties of human serum albumin.
Abstract Albumin is the most abundant plasma protein and serves as a transport and depot protein for numerous endogenous and exogenous compounds. Earlier we had shown that cigarette smoke induces carbonylation of human serum albumin (HSA) and alters its redox state. Here, the effect of whole-phase cigarette smoke on HSA ligand binding properties was evaluated by equilibrium dialysis and size-exclusion HPLC or tryptophan fluorescence. The binding of salicylic acid and naproxen to cigarette smoke-oxidized HSA resulted to be impaired, unlike that of curcumin and genistein, chosen as representative ligands. The binding...
Source: Blood Cells, Molecules and Diseases - May 29, 2014 Category: Hematology Authors: Clerici M, Colombo G, Secundo F, Gagliano N, Colombo R, Portinaro N, Giustarini D, Milzani A, Rossi R, Dalle-Donne I Tags: Blood Cells Mol Dis Source Type: research

Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy
Summary: Relief of ongoing pain may be reflected by increased dopamine efflux in the nucleus accumbens, providing a neurochemical efficacy measure for evaluation of novel analgesics.Abstract: Preclinical assessment of pain has increasingly explored operant methods that may allow behavioral assessment of ongoing pain. In animals with incisional injury, peripheral nerve block produces conditioned place preference (CPP) and activates the mesolimbic dopaminergic reward pathway. We hypothesized that activation of this circuit could serve as a neurochemical output measure of relief of ongoing pain. Medications commonly used clin...
Source: Pain - May 26, 2014 Category: Anesthesiology Authors: Jennifer Y. Xie, Chaoling Qu, Amol Patwardhan, Michael H. Ossipov, Edita Navratilova, Lino Becerra, David Borsook, Frank Porreca Tags: Research papers Source Type: research

A study of the energy absorption and exposure buildup factors of some anti-inflammatory drugs.
In this study, we investigated the radioprotective effects of some analgesic and anti-inflammatory compounds by evaluating buildup factors. The gamma ray energy absorption (EABF) and exposure buildup factors (EBF) were calculated to select compounds in a 0.015-15MeV energy region up to a penetration depth of 40mfp (mean free path). Variations of EABF and EBF with incident photon energy and penetration depth elements were also investigated. Significant variations in both EABF and EBF values were observed for several compounds at the moderate energy region. At energies below 0.15MeV, EABF and EBF values increased with decrea...
Source: Applied Radiation and Isotopes - May 14, 2014 Category: Radiology Authors: Ekinci N, Kavaz E, Ozdemir Y Tags: Appl Radiat Isot Source Type: research

Structural insight into cocrystallization with zwitterionic co-formers: cocrystals of S-naproxen
CrystEngComm, 2014, Advance ArticleDOI: 10.1039/C4CE00353E, PaperNatalia Tumanova, Nikolay Tumanov, Koen Robeyns, Yaroslav Filinchuk, Johan Wouters, Tom LeyssensAmino acids are efficient cocrystal formers towards the compounds that contain a carboxyl group: among levetiracetam, S-naproxen, S-oxiracetam, and S-diprophylline, only S-naproxen yielded cocrystals.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - May 13, 2014 Category: Chemistry Authors: Natalia Tumanova Source Type: research

A novel thermoalkalostable esterase from Acidicaldus sp. strain USBA-GBX-499 with enantioselectivity isolated from an acidic hot springs of Colombian Andes.
In conclusion, according to our knowledge, 499EST is the first thermoalkalostable esterase derived from a Gram-negative thermoacidophilic bacterium. PMID: 24818691 [PubMed - as supplied by publisher] (Source: Applied Microbiology and Biotechnology)
Source: Applied Microbiology and Biotechnology - May 13, 2014 Category: Microbiology Authors: López G, Chow J, Bongen P, Lauinger B, Pietruszka J, Streit WR, Baena S Tags: Appl Microbiol Biotechnol Source Type: research

Use of a Physostigmine Continuous Infusion for the Treatment of Severe and Recurrent Antimuscarinic Toxicity in a Mixed Drug Overdose.
We present a case of physostigmine continuous infusion for the treatment of antimuscarinic symptoms in a polydrug overdose due to the ingestion of diphenhydramine along with bupropion, citalopram, acetaminophen, and naproxen. CASE PRESENTATION: A 13-year-old female presented with hyperthermia, myoclonus and rigidity, hallucinations, severe agitation, and antimuscarinic toxicity including inability to sweat after a polydrug overdose. Several doses of lorazepam were administered followed by physostigmine which produced resolution of hallucinations and attenuation of the antimuscarinic symptoms including perspiration, tem...
Source: Journal of Medical Toxicology - May 6, 2014 Category: Toxicology Authors: Phillips MA, Acquisto NM, Gorodetsky RM, Wiegand TJ Tags: J Med Toxicol Source Type: research

Final Results From the 16‐Year Sumatriptan, Naratriptan, and Treximet Pregnancy Registry
ConclusionsThe Sumatriptan, Naratriptan, and Treximet Pregnancy Registry detected no signal of teratogenicity associated with major birth defects for sumatriptan. This finding is consistent with results from other observational studies using a variety of control groups. Enrollment in the registry was insufficient to permit definitive conclusions of the risks associated with naratriptan or sumatriptan/naproxen sodium tablets, or to assess the risk of individual birth defects in any of the products studied. Low enrollment and high rates of loss to follow up within the registry over an extended period of time led the registry...
Source: Headache: The Journal of Head and Face Pain - May 1, 2014 Category: Neurology Authors: Sara A. Ephross, Susan M. Sinclair Tags: Research Submission Source Type: research

Sildenafil can induce the onset of a cluster headache bout.
We report the case of a man who experienced a cluster headache attack following each of 2 sildenafil doses. His symptoms were resolved by adding naproxen to his treatment regimen and changing his ED treatment from 50 mg of sildenafil to 5 mg of vardenafil. To our knowledge, no study has reported cluster headaches triggered by the less commonly used PDE-5 inhibitors, namely vardenafil and tadalafil. Urologists should be cautious in prescribing sildenafil to patients with ED and with a history of cluster headaches. In these patients, they should consider prescribing low-dose vardenafil or tadalafil instead. Failure to recogn...
Source: Canadian Urological Association Journal - May 1, 2014 Category: Urology & Nephrology Authors: Lin GY, Lee JT, Peng GS, Yang FC Tags: Can Urol Assoc J Source Type: research

Su1945 Hydrogen Sulfide (H2S)-Releasing Derivative of Naproxen Atb-346 Protects the Gastric Mucosa Compromised by Stress. A Comparative Study With Naproxen and Cyclooxygenase (COX)-2 Inhibitor
(Source: Gastroenterology)
Source: Gastroenterology - May 1, 2014 Category: Gastroenterology Authors: Marcin Magierowski, Katarzyna Jasnos, Danuta Drozdowicz, Agata Ptak-Belowska, Kyle L. Flannigan, Slawomir Kwiecien, John L. Wallace, Tomasz Brzozowski Source Type: research

Massive Naproxen Overdose with Serial Serum Levels.
CONCLUSION: Hemodialysis and renal replacement therapy may correct the acid base disturbance and provide support in cases of renal impairment in context of naproxen overdose, but further studies are needed to determine the extraction of naproxen. PMID: 24756481 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - April 23, 2014 Category: Toxicology Authors: Al-Abri SA, Anderson IB, Pedram F, Colby JM, Olson KR Tags: J Med Toxicol Source Type: research

Cost Effectiveness of Duloxetine for Osteoarthritis: A Quebec Societal Perspective
ConclusionDuloxetine was cost effective for a cohort of 55‐year‐old patients with OA, and more so in older patients and those with greater AE risks. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - April 22, 2014 Category: Rheumatology Authors: Ronald C. Wielage, Ankur J. Patel, Megha Bansal, Shannon Lee, Robert W. Klein, Michael Happich Tags: Osteoarthritis Source Type: research