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Arylhydrazone Derivatives of Naproxen as NewAnalgesic and Anti-Inflammatory Agents: Design, Synthesis and Molecular Docking Studies
Publication date: Available online 24 May 2016 Source:Journal of Molecular Graphics and Modelling Author(s): Homa Azizian, Zahra Mousavi, Hamidreza Faraji, Mohammad Tajik, Kowsar Bagherzadeh, Peyman Bayat, Abbas Shafiee, Ali Almasirad A series of new arylidenehydrazone derivatives of naproxen were synthesized and evaluated for their analgesic and anti-inflammatory activities. Some of the synthesized analogues showed comparable activities when compared against naproxen for their analgesic and anti-inflammatory properties. 2-(6-methoxy-2-naphthyl)-N′-[(pyridine-4-yl)methylene]propanoic acid hydrazide 4j was found...
Source: Journal of Molecular Graphics and Modelling - May 24, 2016 Category: Molecular Biology Source Type: research
Curcumin Blocks Naproxen-induced Gastric Antral Ulcerations through Inhibition of Lipid Peroxidation and Activation of Enzymatic Scavengers in Rats.
Abstract Curcumin is a polyphenol derived from the plant Curcuma longa, which is used for the treatment of diseases associated with oxidative stress and inflammation. The present study was undertaken to determine the protective effect of curcumin against naproxen-induced gastric antral ulcerations in rats. Different doses (10, 50, and 100 mg/kg) of curcumin or vehicle (curcumin, 0 mg/kg) were pretreated for 3 days by oral gavage, and then gastric mucosal lesions were caused by 80 mg/kg naproxen applied for 3 days. Curcumin significantly inhibited naproxen-induced gastric antral ulcer area and lipid peroxidation in ...
Source: Journal of Microbiology and Biotechnology - May 20, 2016 Category: Biotechnology Authors: Kim JH, Jin S, Kwon HJ, Kim BW Tags: J Microbiol Biotechnol Source Type: research
Severe ocular side effects with acetazolamide: case report.
CONCLUSION: This was an iatrogenic case of acute angle closure induced by an anterior displacement of the irido-lenticular complex, secondary to the use of acetazolamide. The treatment of this condition involves suspending the drug responsible and applying topical corticosteroids, hypotensive and cycloplegic eye drops, with the aim of lowering the eye pressure and the degree of myopia due to the re-positioning of the irido-lenticular complex. PMID: 27179669 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)
Source: Archivos de la Sociedad Espanola de Oftalmologia - May 18, 2016 Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
Use of non-steroidal anti-inflammatory drugs correlates with the risk of venous thromboembolism in knee osteoarthritis patients: a UK population-based case-control study
Conclusion. Compared with the remote users of NSAIDs, the risk of VTE increased for current users of diclofenac, ibuprofen, meloxicam, and coxibs, but not for naproxen, in the knee OA population. Clinicians should consider the risk profile for specific NSAIDs when recommending their use. (Source: Rheumatology)
Source: Rheumatology - May 17, 2016 Category: Rheumatology Authors: Lee, T., Lu, N., Felson, D. T., Choi, H. K., Dalal, D. S., Zhang, Y., Dubreuil, M. Tags: Osteoarthritis and Cartilage CLINICAL SCIENCE Source Type: research
Effects of reclaimed water matrix on fate of pharmaceuticals and personal care products in soil.
Abstract Reclaimed water is increasingly used to supplement water resources. However, reclaimed water has a complex matrix, which includes emerging chemical contaminants, that is introduced to the soil when this water is used for irrigation. The effects of microbial activity, dissolved matter, nutrients, and particulate matter in reclaimed water on half-life of 11 pharmaceutical and personal care products (PPCPs) in soil were investigated with 7 treatment waters, namely swine lagoon effluent (either unaltered, sterilized, or filtered and sterilized) and nanopure water (either unaltered or with added nitrogen, phosp...
Source: Chemosphere - May 12, 2016 Category: Chemistry Authors: Dodgen LK, Zheng W Tags: Chemosphere Source Type: research
Preparation and characterization of dual-template molecularly imprinted monolith with metal ion as pivot
Publication date: Available online 10 May 2016 Source:European Polymer Journal Author(s): Jing Zhang, Fang Li, Xian-Hua Wang, Dan Xu, Yan-Ping Huang, Zhao-Sheng Liu In this work, a method for improving imprinting efficiency of dual-templates molecularly imprinted polymer was developed based on strategy of metal ion as pivot. Two templates, naproxen (NAP) and ketoprofen (KET), were simultaneously imprinted using 4-vinylpyridine (4-VP) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linker with Co2+ as pivot. A ternary mixture of dimethyl formamide (DMF)- dimethyl sulfoxide (DMSO)- 1-butyl-3-...
Source: European Polymer Journal - May 11, 2016 Category: Chemistry Source Type: research
Method for quantifying NSAIDs and clofibric acid in aqueous samples, lumpfish (Cyclopterus lumpus) roe, and zebrafish (Danio rerio) eleutheroembryos and evaluation of their bioconcentration in zebrafish eleutheroembryos.
Abstract Pharmaceuticals such as nonsteroidal anti-inflammatory drugs (NSAIDs) and lipid regulators are being repeatedly detected at low concentrations (pg · mL(-1)-ng · mL(-1)) in the environment. A large fraction of these compounds are ionizable. Ionized compounds show different physico-chemical properties and environmental behavior in comparison to their neutral analogs; as a consequence, the quantification methods currently available, based on the neutral molecules, might not be suitable to detect the corresponding ionized compounds. To overcome this problem, we developed a specific analytical method ...
Source: Environmental Science and Pollution Research International - May 11, 2016 Category: Environmental Health Authors: Molina-Fernandez N, Perez-Conde C, Rainieri S, Sanz-Landaluze J Tags: Environ Sci Pollut Res Int Source Type: research
Biofabrication of genipin-crosslinked peptide hydrogels and their use in the controlled delivery of Naproxen.
Abstract The synthesis and optimization of peptide-based hydrogel materials have gained growing interest in the last years, thanks to their properties, that make them appealing for diverse biotechnological applications, with a particular focus in the field of biomedicine. The self-assembling abilities of low molecular weight peptides make them ideal for designing advanced materials using mild reaction conditions. In this work, a biocatalytic approach has been used for the synthesis of an Fmoc-tripeptide that is able to self-assemble in water affording a self-supporting hydrogel. The mechanical properties of this ma...
Source: New Biotechnology - May 7, 2016 Category: Biotechnology Authors: Chronopoulou L, Toumia Y, Cerroni B, Pandolfi D, Paradossi G, Palocci C Tags: N Biotechnol Source Type: research
Introduction of high nitrogen doped graphene as a new cationic carrier in electromembrane extraction
This paper proposes for the first time, the use of high nitrogen doped graphene (HND‐G) as a new cationic carrier for the enhancement of electromembrane extraction (EME) performance. Sensitivity of EME was improved by the modification of supported liquid membrane composition through the addition of HND‐G into 1‐octanol for the extraction of naproxen and sodium diclofenac as model acidic drugs. The comparison between HND‐G‐modified EME and conventional EME showed that HND‐G could increase the overall partition coefficient of acidic drugs in the membrane due to the fact that HND‐G acts as an ion pair reagent an...
Source: Electrophoresis - May 2, 2016 Category: Biochemistry Authors: Atefe Atarodi, Mahmoud Chamsaz, Ali Zeraatkar Moghaddam, Hadi Tabani Tags: Research Article Source Type: research
Antinociceptive Activity of an Ethanol Extract of Justicia spicigera
ABSTRACT The aim of the present study was to evaluate the antinociceptive and sedative activity of an ethanol extract of Justicia spicigera an evergreen used in Mexican traditional medicine for the relief of pain, wounds, fever and inflammation. At 200 mg/kg po, the maximum dose examined, the ethanol extract of J. spicigera (JSE) had analgesic activity in mice in the acetic acid writhing test, the second phase of the formalin test and the tail flick test that was similar in efficacy to the NSAID, naproxen (150 mg/kg po). JSE was inactive in the hot plate test and and the ketamine‐induced sleeping time test; it had...
Source: Drug Development Research - May 1, 2016 Category: Drugs & Pharmacology Authors: Juan Ramón Zapata‐Morales, Angel Josabad Alonso‐Castro, Fabiola Domínguez, Candy Carranza‐Álvarez, Luis Manuel Orozco Castellanos, Rosa María Martínez‐Medina, José Pérez‐Urizar Tags: Research Article Source Type: research
Top 20 Research Studies of 2015 for Primary Care Physicians.
This article, the fifth installment in this annual series, summarizes the 20 POEMs based on original research studies judged to have the greatest clinical relevance for family physicians. Key recommendations include questioning the need for backup throat cultures; avoiding early imaging and not adding cyclobenzaprine or oxycodone to naproxen for patients with acute low back pain; and encouraging patients with chronic or recurrent low back pain to walk. Other studies showed that using a nicotine patch for more than eight weeks has little benefit; that exercise can prevent falls that cause injury in at-risk older women; and ...
Source: American Family Physician - May 1, 2016 Category: Primary Care Authors: Ebell MH, Grad R Tags: Am Fam Physician Source Type: research
Impact of chirality on the photoinduced charge transfer in linked systems containing naproxen enantiomers
Phys. Chem. Chem. Phys., 2016, Advance ArticleDOI: 10.1039/C5CP07305G, PaperE. A. Khramtsova, D. V. Sosnovsky, A. A. Ageeva, E. Nuin, M. L. Marin, P. A. Purtov, S. S. Borisevich, S. L. Khursan, H. D. Roth, M. A. Miranda, V. F. Plyusnin, T. V. LeshinaThe model reaction of photoinduced electron transfer in dyads has been used to compare the reactivity of anti-inflammatory drug, (S)-naproxen and its (R)-isomer.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 21, 2016 Category: Chemistry Authors: E. A. Khramtsova Source Type: research
Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults.
CONCLUSIONS: The conclusions of this review were not changed. Combination treatment was effective in the acute treatment of migraine headaches. The effect was greater than for the same dose of either sumatriptan or naproxen alone, but additional benefits over sumatriptan alone were not large. More participants achieved good relief when medication was taken early in the attack, when pain was still mild. Adverse events were more common with the combination and sumatriptan alone than with placebo or naproxen alone. PMID: 27096438 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 20, 2016 Category: Journals (General) Authors: Law S, Derry S, Moore RA Tags: Cochrane Database Syst Rev Source Type: research
Molecules, Vol. 21, Pages 509: Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage
In this study, the behavior of the recently identified sodium naproxen-lactose-tetrahydrate co-crystal and the co-amorphous mixture of sodium, naproxen, and lactose was investigated. The structure of the co-crystal is described using single-crystal X-ray diffraction. The structural analysis revealed a monoclinic lattice, space group P21, with the asymmetric unit containing one molecule of lactose, one of naproxen, sodium, and four water molecules. Upon heating, it was observed that the co-crystal transforms into a co-amorphous system due to the loss of its crystalline bound water. Dehydration and co-amorphization were stud...
Source: Molecules - April 19, 2016 Category: Chemistry Authors: Ioana SovagoWenbo WangDanwen QiuDhara RaijadaJukka RantanenHolger GrohganzThomas RadesAndrew BondKorbinian Löbmann Tags: Article Source Type: research
Drugs for the acute treatment of migraine in children and adolescents.
CONCLUSIONS: Low quality evidence from two small trials shows that ibuprofen appears to improve pain freedom for the acute treatment of children with migraine. We have only limited information on adverse events associated with ibuprofen in the trials included in this review. Triptans as a class are also effective at providing pain freedom in children and adolescents but are associated with higher rates of minor adverse events. Sumatriptan plus naproxen sodium is also effective in treating adolescents with migraine. PMID: 27091010 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 19, 2016 Category: Journals (General) Authors: Richer L, Billinghurst L, Linsdell MA, Russell K, Vandermeer B, Crumley ET, Durec T, Klassen TP, Hartling L Tags: Cochrane Database Syst Rev Source Type: research
Molecules, Vol. 21, Pages 420: Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives
The current study focuses on the synthesis of several hybrid individuals combining a natural oleanolic acid skeleton and synthetic nonsteroidal anti-inflammatory drug moieties (NSAIDs). It studied structural modifications of the oleanolic acid structure by use of the direct reactivity of hydroxyl or hydroxyimino groups at position C-3 of the triterpenoid skeleton with the carboxylic function of anti-inflammatory drugs leading to new perspective compounds with high potential pharmacological activities. Novel ester- and iminoester-type derivatives of oleanolic unit with the different NSAIDs, such as ibuprofen, aspirin, napro...
Source: Molecules - April 12, 2016 Category: Chemistry Authors: Anna PawełczykDorota OlenderKatarzyna Sowa-KasprzakLucjusz Zaprutko Tags: Article Source Type: research
Impact of Chirality on the Photo-Induced Charge Transfer in Linked Systems Containing Naproxen Enantiomers.
Phys. Chem. Chem. Phys., 2016, Accepted ManuscriptDOI: 10.1039/C5CP07305G, PaperEkaterina Andreevna Khramtsova, Denis Viktorovich Sosnovsky, Alexandra Andreevna Ageeva, Edurne Nuin, Maria Luisa Marin, Petr A. Purtov, Sophia S. Borisevich, Sergey L. Khursan, Heinz Roth, Miguel Miranda, Victor F. Plyusnin, Tatyana LeshinaThe model reaction, the photo-induced donor-acceptor interaction in linked systems - dyads, have been used to study the comparative reactivity of a well-known anti-inflammatory drug, (S)-naproxen (NPX) and its (R)-isomer....The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. ...
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 11, 2016 Category: Chemistry Authors: Ekaterina Andreevna Khramtsova Source Type: research
Minimal-change disease and interstitial nephritis secondary to non-steroidal anti-inflammatory drugs (naproxen).
PMID: 27203163 [PubMed - as supplied by publisher] (Source: Therapie)
Source: Therapie - April 11, 2016 Category: Psychiatry & Psychology Authors: Baccouche K, Alaya Z, Azzabi A, Ben Abdelkarim S, Belghali S, El Amri N, Zeglaoui H, Slim R, Bouajina E Tags: Therapie Source Type: research
Fixed Drug Eruption Due to Selective Hypersensitivity to Naproxen with Tolerance to other Propionic Acid NSAIDs.
CONCLUSION: In our patient PT confirmed the diagnosis and allowed us to study the cross-reactivity between NSAIDs of the same group, and confirmed by SBOCT. Cross-reactivity between propionic acid derivatives was studied. This is a case of hypersensitivity to naproxen with good tolerance to other propionic acids NSAIDs (ibuprofen and ketoprofen) and nabumetone, confirmed by PT and SBOCT. Some relavent patents for fixed drug eruption are discussed. PMID: 27041368 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - April 7, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Experimental and theoretical study of molecular interactions between 2-vinyl pyridine and acidic pharmaceuticals used as multi-template molecules in molecularly imprinted polymer
In this study, a multi-template molecularly imprinted polymer (MIP) for ibuprofen, naproxen and diclofenac was synthesized in an oil bath set at 70 °C for 24 hours. 2-vinyl pyridine, ethylene glycol dimethacrylate, toluene and 1,1’-azobis-(cyclohexanecarbonitrile) were used as functional monomer, cross-linker, porogen and radical initiator, respectively. A non-imprinted polymer (NIP) was synthesized using a similar approach with the omission of templates. Monomer-template interactions were examined using Molecular Dynamics and Fourier Transform Infrared Spectroscopy (FTIR). Both molecular dynamics and FT-IR results indi...
Source: Reactive and Functional Polymers - April 3, 2016 Category: Chemistry Source Type: research
Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) like meclofenamate sodium (MS), used to reduce pain, has been associated with an increased risk of cardiovascular disease (CVD). Naproxen (NAP), another NSAID, is not associated with increased risk of CVD. The molecular mechanism(s) by which NSAIDs induce CVD is unknown.We investigated the effects of MS and NAP on protein homeostasis and cardiotoxicity in rat cardiac H9c2 cells and murine neonatal cardiomyocytes.MS, but not NAP, significantly inhibited proteasome activity and reduced cardiac cell viability at pharmacological levels found in humans. (Source: Journal o...
Source: Journal of Molecular and Cellular Cardiology - April 3, 2016 Category: Cytology Authors: Rajeshwary Ghosh, Soyun M. Hwang, Ziyou Cui, Jennifer E. Gilda, Aldrin V. Gomes Source Type: research
Conservative treatment of acute knee osteoarthritis: A review of the Cochrane Library
Conclusions Five main strategies for the conservative treatment of knee osteoarthritis exist that must be used before indicating surgical treatment: medical treatment, physical medicine and rehabilitation, intra-articular injections, acupuncture, and self-management education programs. (Source: Journal of Acute Disease)
Source: Journal of Acute Disease - April 2, 2016 Category: Emergency Medicine Source Type: research
Versatile Coating of CoFe2O4 NPs for the Sustained
Release of Anti-Inflammatory
Drug Naproxen and in Vivo Target Selectivity
ACS Applied Materials & InterfacesDOI: 10.1021/acsami.6b00408 (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - March 29, 2016 Category: Materials Science Authors: Violetta Georgiadou, George Makris, Dionysia Papagiannopoulou, Georgios Vourlias and Catherine Dendrinou-Samara Source Type: research
Development and validation of an LC-ESI-MS/MS method for the simultaneous quantification of naproxen and sumatriptan in human plasma: application to a pharmacokinetic study.
Abstract A sensitive and fast liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for the simultaneous quantification of naproxen and sumatriptan in human plasma. A simple liquid-liquid extraction procedure, with a mixture of ethyl acetate, methyl tert-butyl ether, and dichloromethane (4:3:3, v/v), was used for the cleanup of plasma. Naratriptan and aceclofenac were employed as internal standards. The analyses were carried out using an ACE C18 column (50 × 4.6 mm i.d.; particle size 5 μm) and a mobile phase consisting of 2 mM aqueous ammo...
Source: Analytical and Bioanalytical Chemistry - March 28, 2016 Category: Chemistry Authors: Brêtas JM, César IC, Brêtas CM, Teixeira LS, Bellorio KB, Mundim IM, Pianetti GA Tags: Anal Bioanal Chem Source Type: research
Course of active inflammatory and fatty lesions in patients with early axial spondyloarthritis treated with infliximab plus naproxen as compared to naproxen alone: Results from the INFAST study
Conclusion. Effective anti‐inflammatory treatment of axSpA was associated with an increase in fatty lesion scores that was independent of the treatment arm. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 25, 2016 Category: Rheumatology Authors: Denis Poddubnyy, Joachim Listing, Joachim Sieper Tags: Brief Report Source Type: research
Hydroxy double salts loaded with bioactive ions: Synthesis, intercalation mechanisms, and functional performance
Publication date: June 2016 Source:Journal of Solid State Chemistry, Volume 238 Author(s): Abdessamad Y. A. Kaassis, Si-Min Xu, Shanyue Guan, David G. Evans, Min Wei, Gareth R. Williams The intercalation of the anions of diclofenac (Dic), naproxen (Nap), and valproic acid (Val) into three hydroxy double salts (HDSs) has been explored in this work. Experiments were performed with [Co1.2Zn3.8(OH)8](NO3)2·2H2O (CoZn-NO3), [Ni2Zn3(OH)8](NO3)2·2H2O (NiZn-NO3) and [Zn5(OH)8](NO3)2·2H2O (Zn-NO3). It proved possible to intercalate diclofenac and naproxen into all three HDSs. In contrast, Val could be intercalated into C...
Source: Journal of Solid State Chemistry - March 22, 2016 Category: Chemistry Source Type: research
Mesoporous silica based MCM-41 as solid-phase extraction sorbent combined with micro-liquid chromatography-quadrupole-mass spectrometry for the analysis of pharmaceuticals in waters.
Abstract This paper reports the first application of the silica based mesoporous material MCM-41 as a sorbent in solid phase extraction, to pre-concentrate pharmaceuticals of very different polarity (atenolol, nadolol, pindolol, timolol, bisoprolol, metoprolol, betaxolol, ketoprofen, naproxen, ibuprofen, diclofenac, tolfenamic acid, flufenamic acid and meclofenamic acid) in surface waters. The analytes were extracted from 100mL water samples at pH 2.0 (containing 10(-3)mol/L of sodium chloride) by passing the solution through a cartridge filled with 100mg of MCM-41. Following elution, the pharmaceuticals were deter...
Source: Talanta - March 20, 2016 Category: Chemistry Authors: Dahane S, Martínez Galera M, Marchionni ME, Socías Viciana MM, Derdour A, Gil García MD Tags: Talanta Source Type: research
Coatings of molecularly imprinted polymers based on polyhedral oligomeric silsesquioxane for open tubular capillary electrochromatography.
Abstract Polyhedral oligomeric silsesquioxane (POSS) was successfully applied, for the first time, to prepare imprinted monolithic coating for capillary electrochromatography. The imprinted monolithic coating was synthesized with a mixture of PSS-(1-Propylmethacrylate)-heptaisobutyl substituted (MA 0702), S-amlodipine (template), methacrylic acid (functional monomer), and 2-methacrylamidopropyl methacrylate (crosslinker), in a porogenic mixture of toluene-isooctane. The influence of synthesis parameters on the imprinting effect and separation performance, including the amount of MA 0702, the ratio of template to mo...
Source: Talanta - March 20, 2016 Category: Chemistry Authors: Zhao QL, Zhou J, Zhang LS, Huang YP, Liu ZS Tags: Talanta Source Type: research
Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis
Publication date: Available online 18 March 2016 Source:The Lancet Author(s): Bruno R da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Jüni, Sven Trelle Background Non-steroidal anti-inflammatory drugs (NSAIDs) are the backbone of osteoarthritis pain management. We aimed to assess the effectiveness of different preparations and doses of NSAIDs on osteoarthritis pain in a network meta-analysis. Methods For this network meta-analysis, we considered randomised trials comparing any of the following interventions: NSAIDs, paracetamol, or placebo, for the treatment of osteoarthritis pain. ...
Source: The Lancet - March 18, 2016 Category: Journals (General) Source Type: research
[Comment] Does paracetamol still have a future in osteoarthritis?
This study looked at the so-called coxibs as well as diclofenac, naproxen, ibuprofen, and paracetamol, which were mainly used as comparators. (Source: LANCET)
Source: LANCET - March 17, 2016 Category: Journals (General) Authors: Nicholas Moore, Francesco Salvo, Mai Duong, Sinem Ezgi Gulmez Tags: Comment Source Type: research
Sonocatalytic removal of naproxen by synthesized zinc oxide nanoparticles on montmorillonite.
Abstract ZnO/MMT nanocomposite as sonocatalyst was prepared by immobilizing synthesized ZnO on the montmorillonite surface. The characteristics of as-prepared nanocomposite were studied by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM) and X-ray diffraction (XRD) techniques. The synthesized samples were used as a catalyst for sonocatalytic degradation of naproxen. ZnO/MMT catalyst in the presence of ultrasound irradiation was more effective compared to pure ZnO nanoparticles and MMT particles in the sonocatalysis of naproxen. The effect of different operational paramet...
Source: Ultrasonics Sonochemistry - March 13, 2016 Category: Chemistry Authors: Karaca M, Kıranşan M, Karaca S, Khataee A, Karimi A Tags: Ultrason Sonochem Source Type: research
Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report
Conclusions This is the first reported case, to the best of our knowledge, of the detection of a secondary malignant giant cell tumor of bone based on fever of unknown origin after long-term (40 years) follow-up. After curettage and bone grafting, giant cell tumor of bone may transform to malignancies within a few years or even decades after surgery. Therefore, meticulous follow-up is essential. The fever might be attributable to the tumor releasing inflammatory cytokines. Not only pain and swelling but also continuous pyrexia may suggest the diagnosis of a secondary malignant giant cell tumor of bone. (Source: ...
Source: Journal of Medical Case Reports - March 8, 2016 Category: Journals (General) Source Type: research
A Strategy for Co-former Selection to Design Stable Co-amorphous Formations Based on Physicochemical Properties of Non-steroidal Inflammatory Drugs
Conclusions The results showed a relationship between stable co-amorphous formation and the physicochemical features of the components, which should inform efficient co-former selection to design stable co-amorphous formations. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2016 Category: Drugs & Pharmacology Source Type: research
Gastrointestinal safety, chemotherapeutic potential, and classic pharmacological profile of NOSH‐naproxen (AVT‐219) a dual NO‐ and H2S‐releasing hybrid
Abstract Naproxen (NAP) is a potent nonsteroidal anti‐inflammatory drug (NSAID) with a favorable cardiovascular profile. However, its long‐term use may lead to serious gastrointestinal and renal side effects. NOSH‐ (nitric oxide and hydrogen sulfide) releasing naproxen (NOSH‐NAP, AVT‐219) belongs to a new class of anti‐inflammatory agents designed to overcome these limitations. We compared the gastrointestinal safety, anti‐inflammatory, analgesic, antipyretic, and antiplatelet properties of AVT‐219 to that of NAP in preclinical animal models. We also evaluated its anticancer effects in 11 human cancer cell ...
Source: Pharmacology Research and Perspectives - March 4, 2016 Category: Drugs & Pharmacology Authors: Mitali Chattopadhyay, Ravinder Kodela, Pascale L. Duvalsaint, Khosrow Kashfi Tags: Original Article Source Type: research
Effect of NSAIDs on the aminopeptidase activity of cultured human osteoblasts
The objective was to determine the effect of certain NSAIDs on the AP activity of osteoblasts. Primary cultures of osteoblast were treated with different concentrations of indomethacin, meloxicam, naproxen, nimesulide, and piroxicam. The AP activity was fluorimetrically determined using aminoacyl-β-naphthylamides (aa-βNAs) as substrates: Ala-βNA, Arg-βNA, Gly-βNA, Leu-βNA, Lys-βNA, Met-βNA, and Phe-βNA. The five NSAIDs showed an inhibitory effect of AP activity against the study substrates depending on the dose tested. Meloxicam and piroxicam had the highest inhibitory effect on enzymatic activity, with an IC50 of...
Source: Molecular and Cellular Endocrinology - February 28, 2016 Category: Endocrinology Source Type: research
Novel Naproxen/esomeprazole magnesium compound pellets based on acid-independent mechanism: In vitro and in vivo evaluation.
Authors: Lu J, Kan S, Zhao Y, Zhang W, Liu J Abstract The purpose of this study was to develop the novel Naproxen/Esomeprazole magnesium compound pellets (novel-NAP/EMZ) depending on EMZ acid-independent mechanism which has been proved to be predominate in the mechanism of co-therapy with non-steroidal anti-inflammatory drug. The novel-NAP/EMZ compound pellets, composed of NAP colon-specific pellets (NAP-CSPs) and EMZ modified-release pellets (EMZ-MRPs), were prepared by fluid-bed coating technology with desired in vitro release profiles. The resulting pellets were filled into hard gelatin capsules for in vivo eval...
Source: Drug Development and Industrial Pharmacy - February 25, 2016 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
1: comparative effect of selective and non-selective cox-2 inhibitors on lipid accumulation in human macrophages
Conclusions Here we report that only specific COX-2 inhibitors might contribute to atherogenesis by promoting lipid overload and lipoprotein accumulation. This may explain, in part, the increased CV risk in patients taking COX-2 inhibitors for extended periods. Despite increased scavenger receptor expression, naproxen and acetaminophen do not impact lipid content, perhaps because efflux pathways remain intact. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - February 25, 2016 Category: Research Authors: Kasselman, L., Voloshyna, I., Littlefield, M., Siegart, N., Carsons, S., Gomolin, I., De Leon, J., Reiss, A. Tags: Scientific Session I, 8:30 AM - 10:30 AM, Wednesday, April 13, 2016 Source Type: research
Modeling and predicting the influence of variable factors on dissolution of crystalline pharmaceuticals
Publication date: 12 May 2016 Source:Chemical Engineering Science, Volume 145 Author(s): Raphael Paus, Yuanhui Ji In this work, the dissolution profiles of different crystalline active pharmaceutical ingredients (APIs), which show a diverse water solubility (paracetamol>hydrochlorothiazide>trimethoprim>naproxen>indomethacin>cinnarizine) were measured in water at different temperatures and stirring speeds using a rotating disk system. Meanwhile, the dissolution mechanism of these APIs was analyzed by using a two-step chemical-potential-gradient model. The solubilities and activity coef...
Source: Chemical Engineering Science - February 19, 2016 Category: Chemistry Source Type: research
Efficacy of single-dose, extended-release naproxen sodium 660 mg in postsurgical dental pain: two double-blind, randomized, placebo-controlled trials.
CONCLUSIONS: A single dose of ER naproxen sodium 660 mg significantly reduced moderate to severe dental pain vs. placebo and was comparable to IR naproxen sodium 220 mg tid. Significant pain relief was experienced from 15 min and sustained over 24 h, resulting in a reduced need for rescue medication. ER naproxen sodium 660 mg once daily is a convenient and effective therapy providing 24 h relief of pain. PMID: 26588111 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research
Indomethacin inhibits tetrodotoxin-resistant Na(+) channels at acidic pH in rat nociceptive neurons.
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are well-known inhibitors of cyclooxygenases (COXs) and are widely used for the treatment of inflammatory pain; however several NSAIDs display COX-independent analgesic action including the inhibition of voltage-gated Na(+) channels expressed in primary afferent neurons. In the present study, we examined whether NSAIDs modulate tetrodotoxin-resistant (TTX-R) Na(+) channels and if this modulation depends on the extracellular pH. The TTX-R Na(+) currents were recorded from small-sized trigeminal ganglion neurons by using a whole-cell patch clamp technique. Among...
Source: Neuropharmacology - February 17, 2016 Category: Drugs & Pharmacology Authors: Nakamura M, Jang IS Tags: Neuropharmacology Source Type: research
In acute low back pain, adding oxycodone/acetaminophen or cyclobenzaprine to naproxen did not improve pain or function.
PMID: 26882304 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - February 16, 2016 Category: Internal Medicine Authors: Carpenter CR Tags: Ann Intern Med Source Type: research
Carbon dioxide mediated vasomotion of extra-cranial cerebral arteries in humans: A role for prostaglandins?
This article is protected by copyright. All rights reserved. PMID: 26880615 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 16, 2016 Category: Physiology Authors: Hoiland RL, Tymko MM, Bain AR, Wildfong KW, Monteleone B, Ainslie PN Tags: J Physiol Source Type: research
Competitive binding of anticancer drugs 5-fluorouracil and cyclophosphamide with serum albumin: Calorimetric insights
This article is part of a Special Issue entitled Microcalorimetry in the BioSciences — Principles and Applications, edited by Fadi Bou-Abdallah. Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 15, 2016 Category: Biochemistry Source Type: research
Naproxen Alone May Be Best for Acute Low Back Pain.
PMID: 26926822 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - February 15, 2016 Category: Primary Care Authors: Slawson D Tags: Am Fam Physician Source Type: research
The Pharmacology of Indomethacin.
CONCLUSIONS: NSAIDs easily enter the brain, but their high protein binding limits absolute amount of entry. All work similarly as either nonselective or selective cyclooxygenase inhibitors, but indomethacin may have more potent vasoconstrictive activity and unique direct neuronal or nitric oxide-dependent inhibitory pathway activity. PMID: 26865183 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - February 11, 2016 Category: Neurology Authors: Lucas S Tags: Headache Source Type: research
Sorption of diclofenac and naproxen onto MWCNT in model wastewater treated by H2O2 and/or UV.
Abstract The application of oxidation processes such as UV and/or H2O2 will change the physicochemical properties of carbon nanotubes (CNT). It may affect the sorption affinity of CNT to different contaminants and then affect their fate in the environment. In the present study the adsorption of two very common used pharmaceuticals (diclofenac and naproxen) onto CNT treated by UV, H2O2 or UV/H2O2 was investigated. Four different adsorption models (Freundlich, Langmuir, Temkin, Dubinin-Radushkevich) were tested. The best fitting of experimental data was observed for Freundlich or Langmuir model. The significant relat...
Source: Chemosphere - February 8, 2016 Category: Chemistry Authors: Czech B, Oleszczuk P Tags: Chemosphere Source Type: research
Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae)
Conclusions C. pulverulents exerts moderate cytotoxic effects in human cancer cells, moderate anti-inflammatory and antinociceptive effects. C. pulverulentus induces antinociceptive effects without inducing sedation. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 6, 2016 Category: Drugs & Pharmacology Source Type: research
Competitive binding of anticancer drugs 5-fluorouracil and cyclophosphamide with serum albumin: Calorimetric insights.
This article is part of a Special Issue entitled Microcalorimetry in the BioSciences - Principles and Applications, edited by Fadi Bou-Abdallah. PMID: 26854955 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 6, 2016 Category: Biochemistry Authors: Thoppil AA, Choudhary S, Kishore N Tags: Biochim Biophys Acta Source Type: research
Chiral Separation of Naproxen with Immobilized Liquid
Organic Process Research & DevelopmentDOI: 10.1021/acs.oprd.6b00020 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - February 5, 2016 Category: Chemistry Authors: Sandra Corderí, Caecilia R. Vitasari, Michal Gramblicka, Thierry Giard and Boelo Schuur Source Type: research
Automated evaluation of protein binding affinity of anti-inflammatory choline based ionic liquids.
Abstract In this work, an automated system for the study of the interaction of drugs with human serum albumin (HSA) was developed. The methodology was based on the quenching of the intrinsic fluorescence of HSA by binding of the drug to one of its binding sites. The fluorescence quenching assay was implemented in a sequential injection analysis (SIA) system and the optimized assay was applied to ionic liquids based on the association of non-steroidal anti-inflammatory drugs with choline (IL-API). In each cycle, 100µL of HSA and 100µL of IL-API (variable concentration) were aspirated at a flow rate of 1mLmin(-1) a...
Source: Talanta - February 4, 2016 Category: Chemistry Authors: Ribeiro R, Pinto PC, Azevedo AM, Bica K, Ressmann AK, Reis S, Saraiva ML Tags: Talanta Source Type: research