Medicine RSS Search Engine

Aleve

This page shows you the latest research publications in this category.

PPCPs removal by aerobic granular sludge membrane bioreactor.
Abstract An aerobic granular sludge membrane bioreactor (GMBR) was applied to the treatment of pharmaceutical and personal care products (PPCPs) wastewater. The influence of granular sludge on five antibiotic and antiphlogistic PPCPs wastewater and the removal effect of methyl alcohol and conventional organic matter were investigated while constantly reducing the density of inflow organic matter. The results showed that the sludge granulation process in the system was rapid but unstable, and that the system exhibits a dissolution-reunion dynamic equilibrium. The reactor demonstrated varying removal effects of PPCPs...
Source: Applied Microbiology and Biotechnology - July 20, 2014 Category: Microbiology Authors: Zhao X, Chen ZL, Wang XC, Shen JM, Xu H Tags: Appl Microbiol Biotechnol Source Type: research

Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study.
CONCLUSIONS: Treatment for 1 to 3 years with naproxen or celecoxib did not protect against cognitive decline in older adults with a family history of AD. PMID: 25022541 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 17, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Double‐injection capillary electrophoresis for the identification of analytes
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - July 17, 2014 Category: Biochemistry Authors: Ahmad Amini Tags: Research Article Source Type: research

Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules
Conclusions: These results indicate that Npx can affect gene expression during osteogenic differentiation of MSCs, and downregulate mineral deposition in the extracellular matrix through IHH signaling. Therefore, Npx could affect MSC-mediated repair of subchondral bone in OA patients. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 17, 2014 Category: Rheumatology Authors: Omar SalemHong WangAbdulrahman AlaseemOvidiu CiobanuInsaf HadjabRahul GawriJohn AntoniouFackson Mwale Source Type: research

[Current state of knowledge and developments in the prophylaxis and acute treatment of migraine.]
Abstract For the acute treatment of the headache phase of a migraine attack, a variety of different pharmacotherapeutic treatment options exist. These range from nonspecifically acting non-opioid analgesics (e.g., paracetamol) and nonsteroidal anti-inflammatory substances (e.g., acetylsalicylic acid, ibuprofen, naproxen, diclofenac) to agents specifically interfering with the serotonin system (ergot alkaloids such as ergotamine and its derivatives, triptans). In patients with significant emesis co-occurring during an attack, additional antiemetics such as metoclopramide or domperidone may be administered. In migrai...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - July 16, 2014 Category: Global & Universal Authors: Schriever J, Bühlen M, Broich K Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

Nonsteroidal Anti-Inflammatory Drugs and Cardiovascular Outcomes in Women: Results From the Women's Health Initiative [Original Articles]
Conclusions— Regular use of selective cox-2 inhibitors and nonselective NSAIDs with cox-2>cox-1 inhibition showed a modestly increased hazard for cardiovascular events. Nonselective agents with cox-1>cox-2 inhibition were not associated with increased cardiovascular risk. Clinical Trial Registration— URL: www.clinicaltrials.gov. Unique identifier: NCT00000611. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - July 15, 2014 Category: Cardiology Authors: Bavry, A. A., Thomas, F., Allison, M., Johnson, K. C., Howard, B. V., Hlatky, M., Manson, J. E., Limacher, M. C. Tags: Risk Factors Original Articles Source Type: research

Capability of the natural microbial community in a river water ecosystem to degrade the drug naproxen.
This study shows that with the concentration studied, naproxen was degraded by the natural microbial populations collected from a river chronically contaminated by this pharmaceutical. PMID: 25012207 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - July 12, 2014 Category: Environmental Health Authors: Grenni P, Patrolecco L, Ademollo N, Di Lenola M, Barra Caracciolo A Tags: Environ Sci Pollut Res Int Source Type: research

Does the use of antipyretics prolong the duration of fever or illness?
Review scope Studies were selected which compared the use of antipyretics with no antipyretics in children with acute febrile infectious illness. Outcomes included author-defined time to fever resolution, and infection-specific indicators of disease resolution. Review methods Medline and Embase (to November 2012) were searched for randomised controlled trials (RCTs) and quasi RCTs. Language restrictions were not specified. Quality of studies was assessed using the Cochrane risk of bias tool. Reference lists and Google Scholar were hand searched. Screening and searching was performed by two authors independently. Six studie...
Source: Archives of Disease in Childhood - Education and Practice - July 11, 2014 Category: Pediatrics Authors: Williams, C., Roland, D. Tags: Clinical trials (epidemiology), TB and other respiratory infections, Travel medicine, Tropical medicine (infectious diseases), Child health, Infant health, Screening (epidemiology), Screening (public health) Picket Source Type: research

Combination of tocolytic agents for inhibiting preterm labour.
CONCLUSIONS: It is unclear whether a combination of tocolytic drugs for preterm labour is more advantageous for women and/or newborns due to a lack of large, well-designed trials including the outcomes of interest. There are no trials of combination regimens using widely used tocolytic agents, such as calcium channel blockers (nifedipine) and/or oxytocin receptor antagonists (atosiban). Further trials are needed before specific conclusions on use of combination tocolytic therapy for preterm labour can be made. PMID: 25010869 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - July 11, 2014 Category: Journals (General) Authors: Vogel JP, Nardin JM, Dowswell T, West HM, Oladapo OT Tags: Cochrane Database Syst Rev Source Type: research

Fast ibuprofen, ketoprofen and naproxen simultaneous determination in human serum for clinical toxicology by GC-FID.
CONCLUSION: The entire sample preparation procedure is completed within 5minutes and the quantitative results are available within 35min. The method was successfully applied to quantify the selected compounds in serum of patients from emergency units. PMID: 25003797 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - July 5, 2014 Category: Biochemistry Authors: Hložek T, Bursová M, Cabala R Tags: Clin Biochem Source Type: research

Enhanced catalysis and enantioselective resolution of racemic naproxen methyl ester by lipase encapsulated within iron oxide nanoparticles coated with calix[8]arene valeric acid complexes
In this study, two types of nanoparticles have been driven as additives for the encapsulation of Candida rugosa lipase via the sol-gel method. In one case, the nanoparticles were covalently...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - July 3, 2014 Category: Molecular Biology Authors: Mustafa Yilmaz Source Type: research

Transformation and removal pathways of four common PPCP/EDCs in soil.
This study examined four PPCP/EDCs (bisphenol A, diclofenac, naproxen, and 4-nonylphenol) in soil by using (14)C-labeling and analyzing mineralization, extractable residue, bound residue, and formation of transformation products. At the end of 112 d of incubation, the majority of (14)C-naproxen and (14)C-diclofenac was mineralized to (14)CO2, while a majority of (14)C-bisphenol A and (14)Cnonylphenol was converted to bound residue. After 112 d, the estimated half-lives of the parent compounds were only 1.4-5.4 d. However a variety of transformation products were found and several for bisphenol A and diclofenac were iden...
Source: Environmental Pollution - July 2, 2014 Category: Environmental Health Authors: Dodgen LK, Li J, Wu X, Lu Z, Gan JJ Tags: Environ Pollut Source Type: research

Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles: an experimental comparative rat model.
CONCLUSION: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle. PMID: 24954342 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 28, 2014 Category: Universities & Medical Training Authors: Chin HY, Changchien E, Lin MF, Chiang CH, Wang CJ Tags: Yonsei Med J Source Type: research

Assessment of drug entrapment within liposomes using photophysical probes.
Abstract The photophysical and photochemical behavior of (R)-cinacalcet (CIN) and (S)-naproxen (NPX) entrapped within liposomes has been studied. For this purpose, liposome encapsulated drugs have been prepared through thin layer evaporation and characterized by transmission electron microscopy, cryoscopy scanning electron microscopy and dynamic light scattering. Steady state and time-resolved fluorescence experiments showed similar spectra, emission quantum yields, singlet energies and lifetimes for the selected drugs, outside and inside liposomes. By contrast, laser flash photolysis experiments revealed an import...
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 25, 2014 Category: Drugs & Pharmacology Authors: Oliverio F, Nuin E, Andreu I, Ragno G, Miranda MA Tags: Eur J Pharm Biopharm Source Type: research

Neutrophil migration towards C5a and CXCL8 is prevented by non‐steroidal anti‐inflammatory drugs via inhibition of different pathways
Conclusion and ImplicationsTreatment with NSAIDs reduced C5a‐ and CXCL8‐induced neutrophil migration and F‐actin polymerization via different mechanisms. Inhibition by ibuprofen was associated with integrin down‐regulation, while naproxen and oxaprozin blocked the PI3K/Akt pathway. Both NSAID actions were independent of COX inhibition and PGE2 release. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - June 25, 2014 Category: Drugs & Pharmacology Authors: Maria Bertolotto, Paola Contini, Luciano Ottonello, Aldo Pende, Franco Dallegri, Fabrizio Montecucco Tags: RESEARCH PAPER Source Type: research

A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain.
CONCLUSIONS: The addition of insomnia-specific therapy to a standardized naproxen pain regimen significantly improves sleep, pain, and depression in patients with chronic low back pain (LBP). The findings indicate the importance of administering both sleep and pain-directed therapies to patients with LBP in clinical practice and provide strong evidence that improving sleep disturbance may improve pain. TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT00365976. CITATION: Goforth HW, Preud'homme XA, Krystal AD. A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in p...
Source: Pain Physician - June 7, 2014 Category: Anesthesiology Authors: Goforth HW, Preud'homme XA, Krystal AD Tags: Sleep Source Type: research

Liquid chromatographic enantioseparation of (RS)-mexiletine and (RS)-fluoxetine using chiral derivatizing reagents synthesized with (S)-naproxen moiety.
Abstract Enantiomeric separation of racemic mexiletine and fluoxetine was achieved using three chiral derivatizing reagents (CDRs) based on (S)-naproxen. Diastereomers were synthesized by reaction of mexiletine or fluoxetine with the CDRs and were separated on a C18 column under reversed-phase conditions using a binary mixture of acetonitrile and triethylammonium phosphate/water, with UV detection at 230 and 226 nm. The results obtained for enantioseparation of the two drugs using the three CDRs were compiled and compared. The conditions for derivatization and chromatographic separation were optimized. The method...
Source: Biomedical Chromatography : BMC - May 31, 2014 Category: Biomedical Science Authors: Batra S, Bhushan R Tags: Biomed Chromatogr Source Type: research

A Randomized, Double-Blind, Placebo-Controlled Trial of Eszopiclone for the Treatment of Insomnia in Patients with Chronic Low Back Pain
Conclusions:The addition of insomnia-specific therapy to a standardized naproxen pain regimen significantly improves sleep, pain, and depression in patients with chronic low back pain (LBP). The findings indicate the importance of administering both sleep and pain-directed therapies to patients with LBP in clinical practice and provide strong evidence that improving sleep disturbance may improve pain.Trial Registration:clinicaltrials.gov identifier: NCT00365976Citation:Goforth HW, Preud'homme XA, Krystal AD. A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with c...
Source: Sleep - May 30, 2014 Category: Sleep Medicine Source Type: research

The Effect of NSAID Prophylaxis and Operative Variables on Heterotopic Ossification After Hip Arthroscopy
Conclusion: Routine NSAID prophylaxis reduces but does not eliminate the incidence of HO in patients undergoing hip arthroscopy. Heterotopic ossification was more likely to develop in patients undergoing acetabuloplasty along with osteochondroplasty and in those who did not receive prophylactic postoperative NSAIDs. Side effects from the investigated NSAID regimen can be serious and should be weighed against the potential benefits in preventing the formation of HO. (Source: The American Journal of Sports Medicine)
Source: The American Journal of Sports Medicine - May 30, 2014 Category: Sports Medicine Authors: Beckmann, J. T., Wylie, J. D., Kapron, A. L., Hanson, J. A., Maak, T. G., Aoki, S. K. Tags: Hip/Pelvis/Thigh, Hip, femoroactabular impingement, Hip arthroscopy, NSAIDS Hip and Thigh Source Type: research

Cigarette smoke induces alterations in the drug binding properties of human serum albumin.
Abstract Albumin is the most abundant plasma protein and serves as a transport and depot protein for numerous endogenous and exogenous compounds. Earlier we had shown that cigarette smoke induces carbonylation of human serum albumin (HSA) and alters its redox state. Here, the effect of whole-phase cigarette smoke on HSA ligand binding properties was evaluated by equilibrium dialysis and size-exclusion HPLC or tryptophan fluorescence. The binding of salicylic acid and naproxen to cigarette smoke-oxidized HSA resulted to be impaired, unlike that of curcumin and genistein, chosen as representative ligands. The binding...
Source: Blood Cells, Molecules and Diseases - May 29, 2014 Category: Hematology Authors: Clerici M, Colombo G, Secundo F, Gagliano N, Colombo R, Portinaro N, Giustarini D, Milzani A, Rossi R, Dalle-Donne I Tags: Blood Cells Mol Dis Source Type: research

Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy
Summary: Relief of ongoing pain may be reflected by increased dopamine efflux in the nucleus accumbens, providing a neurochemical efficacy measure for evaluation of novel analgesics.Abstract: Preclinical assessment of pain has increasingly explored operant methods that may allow behavioral assessment of ongoing pain. In animals with incisional injury, peripheral nerve block produces conditioned place preference (CPP) and activates the mesolimbic dopaminergic reward pathway. We hypothesized that activation of this circuit could serve as a neurochemical output measure of relief of ongoing pain. Medications commonly used clin...
Source: Pain - May 26, 2014 Category: Anesthesiology Authors: Jennifer Y. Xie, Chaoling Qu, Amol Patwardhan, Michael H. Ossipov, Edita Navratilova, Lino Becerra, David Borsook, Frank Porreca Tags: Research papers Source Type: research

A study of the energy absorption and exposure buildup factors of some anti-inflammatory drugs.
In this study, we investigated the radioprotective effects of some analgesic and anti-inflammatory compounds by evaluating buildup factors. The gamma ray energy absorption (EABF) and exposure buildup factors (EBF) were calculated to select compounds in a 0.015-15MeV energy region up to a penetration depth of 40mfp (mean free path). Variations of EABF and EBF with incident photon energy and penetration depth elements were also investigated. Significant variations in both EABF and EBF values were observed for several compounds at the moderate energy region. At energies below 0.15MeV, EABF and EBF values increased with decrea...
Source: Applied Radiation and Isotopes - May 14, 2014 Category: Radiology Authors: Ekinci N, Kavaz E, Ozdemir Y Tags: Appl Radiat Isot Source Type: research

Structural insight into cocrystallization with zwitterionic co-formers: cocrystals of S-naproxen
CrystEngComm, 2014, Advance ArticleDOI: 10.1039/C4CE00353E, PaperNatalia Tumanova, Nikolay Tumanov, Koen Robeyns, Yaroslav Filinchuk, Johan Wouters, Tom LeyssensAmino acids are efficient cocrystal formers towards the compounds that contain a carboxyl group: among levetiracetam, S-naproxen, S-oxiracetam, and S-diprophylline, only S-naproxen yielded cocrystals.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - May 13, 2014 Category: Chemistry Authors: Natalia Tumanova Source Type: research

A novel thermoalkalostable esterase from Acidicaldus sp. strain USBA-GBX-499 with enantioselectivity isolated from an acidic hot springs of Colombian Andes.
In conclusion, according to our knowledge, 499EST is the first thermoalkalostable esterase derived from a Gram-negative thermoacidophilic bacterium. PMID: 24818691 [PubMed - as supplied by publisher] (Source: Applied Microbiology and Biotechnology)
Source: Applied Microbiology and Biotechnology - May 13, 2014 Category: Microbiology Authors: López G, Chow J, Bongen P, Lauinger B, Pietruszka J, Streit WR, Baena S Tags: Appl Microbiol Biotechnol Source Type: research

Use of a Physostigmine Continuous Infusion for the Treatment of Severe and Recurrent Antimuscarinic Toxicity in a Mixed Drug Overdose.
We present a case of physostigmine continuous infusion for the treatment of antimuscarinic symptoms in a polydrug overdose due to the ingestion of diphenhydramine along with bupropion, citalopram, acetaminophen, and naproxen. CASE PRESENTATION: A 13-year-old female presented with hyperthermia, myoclonus and rigidity, hallucinations, severe agitation, and antimuscarinic toxicity including inability to sweat after a polydrug overdose. Several doses of lorazepam were administered followed by physostigmine which produced resolution of hallucinations and attenuation of the antimuscarinic symptoms including perspiration, tem...
Source: Journal of Medical Toxicology - May 6, 2014 Category: Toxicology Authors: Phillips MA, Acquisto NM, Gorodetsky RM, Wiegand TJ Tags: J Med Toxicol Source Type: research

Sildenafil can induce the onset of a cluster headache bout.
We report the case of a man who experienced a cluster headache attack following each of 2 sildenafil doses. His symptoms were resolved by adding naproxen to his treatment regimen and changing his ED treatment from 50 mg of sildenafil to 5 mg of vardenafil. To our knowledge, no study has reported cluster headaches triggered by the less commonly used PDE-5 inhibitors, namely vardenafil and tadalafil. Urologists should be cautious in prescribing sildenafil to patients with ED and with a history of cluster headaches. In these patients, they should consider prescribing low-dose vardenafil or tadalafil instead. Failure to recogn...
Source: Canadian Urological Association Journal - May 1, 2014 Category: Urology & Nephrology Authors: Lin GY, Lee JT, Peng GS, Yang FC Tags: Can Urol Assoc J Source Type: research

Su1945 Hydrogen Sulfide (H2S)-Releasing Derivative of Naproxen Atb-346 Protects the Gastric Mucosa Compromised by Stress. A Comparative Study With Naproxen and Cyclooxygenase (COX)-2 Inhibitor
(Source: Gastroenterology)
Source: Gastroenterology - May 1, 2014 Category: Gastroenterology Authors: Marcin Magierowski, Katarzyna Jasnos, Danuta Drozdowicz, Agata Ptak-Belowska, Kyle L. Flannigan, Slawomir Kwiecien, John L. Wallace, Tomasz Brzozowski Source Type: research

Final Results From the 16‐Year Sumatriptan, Naratriptan, and Treximet Pregnancy Registry
ConclusionsThe Sumatriptan, Naratriptan, and Treximet Pregnancy Registry detected no signal of teratogenicity associated with major birth defects for sumatriptan. This finding is consistent with results from other observational studies using a variety of control groups. Enrollment in the registry was insufficient to permit definitive conclusions of the risks associated with naratriptan or sumatriptan/naproxen sodium tablets, or to assess the risk of individual birth defects in any of the products studied. Low enrollment and high rates of loss to follow up within the registry over an extended period of time led the registry...
Source: Headache: The Journal of Head and Face Pain - May 1, 2014 Category: Neurology Authors: Sara A. Ephross, Susan M. Sinclair Tags: Research Submission Source Type: research

Massive Naproxen Overdose with Serial Serum Levels.
CONCLUSION: Hemodialysis and renal replacement therapy may correct the acid base disturbance and provide support in cases of renal impairment in context of naproxen overdose, but further studies are needed to determine the extraction of naproxen. PMID: 24756481 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - April 23, 2014 Category: Toxicology Authors: Al-Abri SA, Anderson IB, Pedram F, Colby JM, Olson KR Tags: J Med Toxicol Source Type: research

Cost Effectiveness of Duloxetine for Osteoarthritis: A Quebec Societal Perspective
ConclusionDuloxetine was cost effective for a cohort of 55‐year‐old patients with OA, and more so in older patients and those with greater AE risks. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - April 22, 2014 Category: Rheumatology Authors: Ronald C. Wielage, Ankur J. Patel, Megha Bansal, Shannon Lee, Robert W. Klein, Michael Happich Tags: Osteoarthritis Source Type: research

Naproxen-induced methemoglobinemia in an alcohol-dependent patient
(Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - April 15, 2014 Category: Emergency Medicine Authors: Won Suk Lee, Jang Young Lee, Won Young Sung, Sang Won Seo Source Type: research

Regulation of vincamine biosynthesis and associated growth promoting effects through abiotic elicitation, cyclooxygenase inhibition, and precursor feeding of bioreactor grown Vinca minor hairy roots.
Abstract Hydroxylase/acetyltransferase elicitors and cyclooxygenase inhibitor along with various precursors from primary shikimate and secoiridoid pools have been fortified to vincamine less hairy root clone of Vinca minor to determine the regulatory factors associated with vincamine biosynthesis. Growth kinetic studies revealed that acetyltransferase elicitor acetic anhydride and terpenoid precursor loganin significantly reduce the growth either supplemented alone or in combination (GI = 140.6 ± 18.5 to 246.7 ± 24.3), while shikimate and tryptophan trigger biomass accumulation (GI = 440.2 ± ...
Source: Applied Biochemistry and Biotechnology - April 11, 2014 Category: Biochemistry Authors: Verma P, Khan SA, Mathur AK, Shanker K, Lal RK Tags: Appl Biochem Biotechnol Source Type: research

Intranasal Capsaicin (IC) Rapidly Relieves the Pain of Migraine and Other Severe Headaches (P7.179)
CONCLUSIONS: IC may be an option for rapid analgesia in a range of headache disorders. Nasal sting was not a deterrent for use if IC was perceived effective.Study Supported by: VR1 Inc.Disclosure: Dr. Alexianu has nothing to disclose. Dr. Chatterjee has received personal compensation for activities with VR1 Inc. as an employee. Dr. Chatterjee holds stock and/or stock options in VR1 Inc., which sponsored research in which Dr. Chatterjee was involved as an investigator. (Source: Neurology)
Source: Neurology - April 9, 2014 Category: Neurology Authors: Alexianu, M., Chatterjee, A. Tags: Headache: Treatment Source Type: research

Fate of selected emerging micropollutants during mesophilic, thermophilic and temperature co-phased anaerobic digestion of sewage sludge.
Abstract The removal of endocrine disrupting compounds (EDCs) and non-steroidal anti-inflammatory drugs (NSAIDs) was studied in three lab-scale anaerobic digestion (AD) systems; a single-stage mesophilic, a single-stage thermophilic and a two-stage thermophilic/mesophilic. All micropollutants underwent microbial degradation. High removal efficiency (>80%) was calculated for diclofenac, ibuprofen, naproxen and ketoprofen; whereas triclosan, bisphenol A and the sum of nonylphenol (NP), nonylphenol monoethoxylate (NP1EO) and nonylphenol diethoxylate were moderately removed (40-80%). NSAIDs removal was not affected ...
Source: Bioresource Technology - April 5, 2014 Category: Biotechnology Authors: Samaras VG, Stasinakis AS, Thomaidis NS, Mamais D, Lekkas TD Tags: Bioresour Technol Source Type: research

Evaluation of the effect of naproxen on the pharmacokinetics and pharmacodynamics of apixaban
ConclusionsCo‐administration of naproxen with apixaban results in higher apixaban exposure and appears to occur through increased apixaban bioavailability. The effects on anti‐Xa activity, INR and inhibition of AAI‐PA observed in this study were consistent with the individual pharmacologic effects of apixaban and naproxen. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - April 2, 2014 Category: Drugs & Pharmacology Authors: Charles Frost, Andrew Shenker, Mohit D Gandhi, Janice Pursley, Yu Chen Barrett, Jessie Wang, Donglu Zhang, Wonkyung Byon, Rebecca A Boyd, Frank LaCreta Tags: Drug interactions Source Type: research

[Use and potential risks of over-the-counter analgesics].
DISCUSSION: About one third of the elderly patients took analgesics regularly or as needed. Despite the relatively high use of OTC analgesics, the proportions of duplicate prescription, medication overdoses, and adverse interactions due to OTC products was low. PMID: 24718747 [PubMed - in process] (Source: Schmerz)
Source: Schmerz - April 1, 2014 Category: Anesthesiology Authors: Freytag A, Quinzler R, Freitag M, Bickel H, Fuchs A, Hansen H, Hoefels S, König HH, Mergenthal K, Riedel-Heller SG, Schön G, Weyerer S, Wegscheider K, Scherer M, van den Bussche H, Haefeli WE, Gensichen J Tags: Schmerz Source Type: research

A129: Unlike Fibroblast‐like Synoviocytes from Oligoarticular Juvenile Idiopathic Arthritis, Fibroblast‐like Synoviocytes From Polyarticular Subtype Do Not Display a Chondrocyte Phenotype
Conclusion:Characterization of proteins expressed in cell culture media supernatants reveals that JIA FLS from oligoarticular subtype, either persistent or ext, but not from poly subtype, secrete chondrocyte differentiation markers. The difference more likely is related to differences in underlying disease pathogenesis between the subtypes rather than a medication effect since ¾ JIA patients were on mtx and no patients were on biologic agents at the time the synovial fluid was obtained. These characteristics may have implications for endochondral bone formation and local growth disturbances that are more prominent in olig...
Source: Arthritis and Rheumatism - March 27, 2014 Category: Rheumatology Authors: AnneMarie C. Brescia, Megan Simonds, Suzanne McCahan, Paul T. Fawcett, Carlos D. Rose Tags: Poster Presentations Source Type: research

Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes
This work reports the simultaneous determination of paracetamol and naproxen using multiple-pulse amperometric detection on a multi-walled carbon nanotube modified screen-printed electrode (MWCNT-SPE) adapted in a homemade flow-injection analysis (FIA) cell. A sequence of two potential pulses (+0.30 and +0.70 V for 70 ms each) was applied continuously in such a way that paracetamol is selectively oxidized at +0.30 V and both compounds (paracetamol and naproxen) are oxidized at +0.70 V. Current subtraction after using a correction factor was employed for determination of naproxen without the interference of paracetamol. The...
Source: Journal of the Brazilian Chemical Society - March 26, 2014 Category: Chemistry Source Type: research

Model-based analysis of thromboxane B2 and prostaglandin E2 as biomarkers in the safety evaluation of naproxen.
Abstract The assessment of safety in traditional toxicology protocols rely on evidence arising from observed adverse events (AEs) in animals and on establishing their correlation with different measures of drug exposure (e.g., Cmax and AUC). Such correlations, however, ignore the role of biomarkers, which can provide further insight into the underlying pharmacological mechanisms. Here we use naproxen as a paradigm drug to explore the feasibility of a biomarker-guided approach for the prediction of AEs in humans. A standard toxicology protocol was set up for the evaluation of effects of naproxen in rat, in which fou...
Source: Toxicology and Applied Pharmacology - March 22, 2014 Category: Toxicology Authors: Sahota T, Sanderson I, Danhof M, Pasqua OD Tags: Toxicol Appl Pharmacol Source Type: research

Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern
Commentary on: Nezvalová-Henriksen K, Spigset O, Nordeng H. Effects of ibuprofen, diclofenac, naproxen and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study. BJOG 2013;120:948–59. Context Non-steroidal anti-inflammatory drugs (NSAIDs) are a first-line therapy for frequent medical conditions. The known risks of NSAIDs used in late pregnancy (risk of premature closure of the ductus arteriosus (DA), decreased fetal and neonatal renal function) have led to their contraindication. These effects are linked to their pharmacological properties. Several studies considering NSAIDs as...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Damase-Michel, C., Hurault-Delarue, C. Tags: EBM Aetiology, Epidemiologic studies, Immunology (including allergy), Pregnancy, Child and adolescent psychiatry, Asthma, Drugs: musculoskeletal and joint diseases Source Type: research

Photodegradation of naproxen in water under simulated solar radiation: mechanism, kinetics, and toxicity variation.
Abstract The main objective of this study was to investigate the degradation mechanism, the reaction kinetics, and the evolution of toxicity of naproxen in waters under simulated solar radiation. These criteria were investigated by conducting quenching experiments with reactive oxygen species (ROS), oxygen concentration experiments, and toxicity evaluations with Vibrio fischeri bacteria. The results indicated that the degradation of naproxen proceeds via pseudo first-order kinetics in all cases and that photodegradation included degradation by direct photolysis and by self-sensitization via ROS; the contribution ra...
Source: Environmental Science and Pollution Research International - March 19, 2014 Category: Environmental Health Authors: Ma D, Liu G, Lv W, Yao K, Zhang X, Xiao H Tags: Environ Sci Pollut Res Int Source Type: research

High-performance Enantiomer Separation of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) by 3 μm Reversed-phase Chiral Columns and Application to the Optical Purity Testing of Naproxen Drug Substances and Its Formulations.
Abstract The enantiomer separation of five nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, ketoprofen (KP) and naproxen (NX), which are included in The Japanese Pharmacopoeia 16th edition (JP16), was investigated by employing four kinds of 3 μm reversed-phase chiral columns (AD-3R, AS-3R, OD-3R and OJ-3R). Except for KP, the enantiomers of four NSAIDs were successfully separated by one of the four columns. Among five NSAIDs, only NX has been used as a single enantiomer (S-form, active form) in the clinical field (JP16); therefore, optical purity testing method of NX is required for its quality ev...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 16, 2014 Category: Chemistry Authors: Tanaka M, Nagamatsu K, Nishi H Tags: Anal Sci Source Type: research

Modulation of trichloroethylene in vitro metabolism by different drugs in human.
Abstract Toxicological interactions with drugs have the potential to modulate the toxicity of trichloroethylene (TCE). Our objective is to identify metabolic interactions between TCE and 14 widely used drugs in human suspended hepatocytes and characterize the strongest using microsomal assays. Changes in concentrations of TCE and its metabolites were measured by headspace GC-MS. Results with hepatocytes show that amoxicillin, cimetidine, ibuprofen, mefenamic acid and ranitidine caused no significant interactions. Naproxen and salicylic acid showed to increase both TCE metabolites levels, whereas acetaminophen, carb...
Source: Toxicology in Vitro - March 13, 2014 Category: Toxicology Authors: Rouhou MC, Haddad S Tags: Toxicol In Vitro Source Type: research

A chitosan-polypyrrole magnetic nanocomposite as μ-sorbent for isolation of naproxen.
Abstract An extracting medium based on chitosan-polypyrrole (CS-PPy) magnetic nanocomposite was synthesized by chemical polymerization of pyrrole at the presence of chitosan magnetic nanoparticles (CS-MNPs) for micro-solid phase extraction. In this work, magnetic nanoparticles, the modified CS-MNPs and different types of CS-PPy magnetic nanocomposites were synthesized. Extraction efficiency of the CS-PPy magnetic nanocomposite was compared with the CS-MNPs and Fe3O4 nanoparticles for the determination of naproxen in aqueous samples, via quantification by spectrofluorimetry. The scanning electron microscopy images o...
Source: Analytica Chimica Acta - March 6, 2014 Category: Chemistry Authors: Bagheri H, Roostaie A, Baktash MY Tags: Anal Chim Acta Source Type: research

Neutrophil migration towards C5a and CXCL8 is abrogated by non‐steroidal anti‐inflammatory drugs (NSAIDs) via the inhibition of different pathways
Conclusion and implicationsTreatment with NSAIDs significantly reduces C5a‐ and CXCL8‐induced neutrophil migration and F‐actin polymerization via partially identified cellular and molecular mechanisms. Ibuprofen‐mediated inhibition was associated with integrin down regulation, while Naproxen and Oxaprozin blocked the PI3K/Akt pathway. Both NSAID‐mediated mechanisms were independent of COX inhibition and PGE2 release. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - March 6, 2014 Category: Drugs & Pharmacology Authors: Maria Bertolotto, Paola Contini, Luciano Ottonello, Aldo Pende, Franco Dallegri, Fabrizio Montecucco Tags: Research Paper Source Type: research

Relief of Menstrual Symptoms and Migraine with a Single-Tablet Formulation of Sumatriptan and Naproxen Sodium
Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women)
Source: Journal of Women - March 1, 2014 Category: OBGYN Tags: article Source Type: research

The concept of axial spondyloarthritis. Lessons from the INFAST study
This study is the first investigation of the potential benefits of early tumour necrosis factor (TNF) antagonist treatment in active axial SpA patients who are not yet refractory to NSAID therapy. Additionally, this represents the first randomised controlled clinical trial to use the imaging portion of the Assessment of SpondyloArthritis International Society criteria for axial SpA with active inflammation of the sacroiliac joints on MRI at baseline. Most importantly, the evidence from this study supports early diagnosis and treatment of SpA with a full dose of NSAIDs first, escalating to combination NSAID+TNF... (Source: ...
Source: Annals of the Rheumatic Diseases - February 27, 2014 Category: Rheumatology Authors: Zeidler, H. Tags: Electronic pages Source Type: research

Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes.
Abstract Abstract 1. In order to evaluate the inhibition activity of 1-aminobenzotriazole (ABT) and (-)-borneol (borneol) against cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT), the substrates of these metabolic enzymes were incubated with ABT and borneol in human hepatocytes. We found that 3 mM ABT and 300 μM borneol were the most suitable experimental levels to specifically inhibit CYP and UGT. 2. Montelukast, mefenamic acid, flufenamic acid, diclofenac, tienilic acid, gemfibrozil, ibufenac and repaglinide were markedly metabolized in human hepatocytes, and the metabolism of gemfibrozil, mef...
Source: Xenobiotica - February 27, 2014 Category: Research Authors: Jinno N, Tagashira M, Tsurui K, Yamada S Tags: Xenobiotica Source Type: research

Influence of Compression Forces on the Structural Stability of Naproxen/PVP-VA 64 Solid Dispersions
Molecular PharmaceuticsDOI: 10.1021/mp5001313 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - February 26, 2014 Category: Drugs & Pharmacology Authors: Zelalem Ayenew Worku, Jolie Aarts and Guy Van den Mooter Source Type: research