Aleve This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This page shows you the latest research publications in this category.
Prevalence, trends, patterns and associations of analgesic use in Germany.
CONCLUSIONS: About one in five community dwelling adults aged 18-79 years in Germany use analgesics in a given week. Considering the potential harms of analgesic use, monitoring of prevalence, patterns and determinants of use at the population level are important steps to inform disease prevention and health promotion policies. PMID: 26428626 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 20, 2015 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Low field photo-CIDNP in the intramolecular electron transfer in naproxen-pyrrolidine dyads.
Phys. Chem. Chem. Phys., 2015, Accepted ManuscriptDOI: 10.1039/C5CP04233J, PaperIlya M Magin, Alexandr I. Kruppa, Nikolay Polyakov, Petr A. Purtov, Tatyana Leshina, Alexey S. Kiryutin, Maria Luisa Marin, Miguel Miranda, Edurne NuinPhotoinduced processes with partial (exciplex) and full charge transfer in donor-acceptor systems are of interest due to they are frequently used for modeling drug - protein binding. Low field photo...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - November 20, 2015 Category: Chemistry Authors: Ilya M Magin Source Type: research
Gastrointestinal damage by non-steroidal anti-inflammatory drugs: updated clinical considerations.
Authors: Pellicano R Abstract Gastrointestinal (GI) damage by non-steroidal anti-inflammatory drugs (NSAIDs) is an important Public Health problem due to morbility and elevated mortality rate. The logic behind the development and sale of molecules which are selective cyclooxegnase-2 (COX-2) inhibitors called coxibs, is to limit the undesired effects of traditional NSAIDs, which should theoretically derive from the inhibition of COX-1. With respect to the emphasis of the initial trials, to now epidemiological studies, open-label studies, meta-analyses and reviews of the same data with longer follow-up, have produced...
Source: Minerva Gastroenterologica e Dietologica - November 18, 2015 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Cardiovascular risk associated with celecoxib or etoricoxib: a meta-analysis of randomized controlled trials which adopted comparison with placebo or naproxen.
CONCLUSION: On the basis of our meta-analysis, we can state that symptomatic benefits induced by the prolonged administration of celecoxib may be partially invalidated by a concomitant increase in vascular risk, particularly the increased risk of myocardial infarction found in celecoxib-treated patients, compared to controls taking placebo. In contrast, treatment with etoricoxib proved not to result in an increased risk of serious vascular events when compared with both the placebo and naproxen. Our meta-analysis also denotes that the alternative to COXIBs, represented by naproxen, does not show significant benefit in term...
Source: Minerva Cardioangiologica - November 18, 2015 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Factors influencing naproxen metabolite interference in total bilirubin assays.
CONCLUSION: The acidic pH of diazo-based Dbil assay reagents inhibits the reaction of ODMN with diazo salts. The AU JG Tbil assay is a reliable method to measure Tbil in the setting of naproxen overdose. PMID: 26589001 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 14, 2015 Category: Biochemistry Authors: Saifee NH, Ranjitkar P, Greene DN Tags: Clin Biochem Source Type: research
Single‐drop microextraction combined in‐line with capillary electrophoresis for the determination of non‐steroidal anti‐inflammatory drugs in urine samples
This study describes a method to determine non‐steroidal anti‐inflammatory drugs in urine samples based on the use of single drop microextraction (SDME) in a three‐phase design as a preconcentration technique coupled in‐line to capillary electrophoresis. Different parameters affecting the extraction efficiency of the SDME process were evaluated (e.g. type of extractant, volume of the microdroplet and extraction time). The developed method was successfully applied to the analysis of human urine samples with LODs ranging between 1.0 and 2.5 μg/mL for all of the NSAIDs under study. This method shows RSD values rangin...
Source: Electrophoresis - November 4, 2015 Category: Biochemistry Authors: A. García‐Vázquez, F. Borrull, M. Calull, C. Aguilar Tags: Research Article Source Type: research
Surfactant‐assisted electromembrane extraction combined with capillary electrophoresis as a novel technique for the determination of acidic drugs in biological fluids
In this paper, for the first time, surfactant‐assisted electromembrane extraction coupled with capillary electrophoresis with UV detector was introduced for the extraction of acidic drugs from biological fluids. In this technique, in the presence of the nonionic surfactant in the donor phase, tendency of analyte ions into the supported liquid membrane (SLM) was increased. Naproxen and diclofenac were selected as model acidic drugs. In order to obtain the best extraction efficiency, several factors influencing the extraction efficiency were investigated. Optimal extractions were accomplished with 1‐octanol as the SLM, 1...
Source: Electrophoresis - November 3, 2015 Category: Biochemistry Authors: Ali Reza Fakhari, Kobra Sadat Hasheminasab, Zolfaghar Aladaghlo, Mohammad Hosein Koruni Tags: Research Article Source Type: research
Comparison of the postoperative analgesic effects of paracetamol–codeine phosphate and naproxen sodium–codeine phosphate for lumbar disk surgery
Publication date: September 2015 Source:The Kaohsiung Journal of Medical Sciences, Volume 31, Issue 9 Author(s): Reyhan Polat, Kevser Peker, Çiğdem Topçu Gülöksüz, Julide Ergil, Taylan Akkaya The aim of this study was to compared the efficacy of paracetamol–codeine phosphate and naproxen sodium–codeine phosphate on postoperative pain and tramadol consumption during the first 24 hours after a lumbar disk surgery. After Ethics Committee approval and informed consent had been obtained, 64 patients were allocated into three groups. Patients received oral paracetamol–codeine (300 mg + 30 mg; Group P), nap...
Source: The Kaohsiung Journal of Medical Sciences - October 31, 2015 Category: Universities & Medical Training Source Type: research
Molecules, Vol. 20, Pages 19571-19587: Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin
To benefit from the optimized dissolution properties of active pharmaceutical ingredients in their amorphous forms, co-amorphisation as a viable tool to stabilize these amorphous phases is of both academic and industrial interest. Reports dealing with the physical stability and recrystallization behavior of co-amorphous systems are however limited to qualitative evaluations based on the corresponding X-ray powder diffractograms. Therefore, the objective of the study was to develop a quantification model based on X-ray powder diffractometry (XRPD), followed by a multivariate partial least squares regression approach that en...
Source: Molecules - October 27, 2015 Category: Chemistry Authors: Andreas BeyerHolger GrohganzKorbinian LöbmannThomas RadesClaudia Leopold Tags: Article Source Type: research
Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities
To evaluate long-term clinical and economic outcomes of naproxen, ibuprofen, celecoxib or tramadol for OA patients with cardiovascular disease (CVD) and diabetes. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 22, 2015 Category: Rheumatology Authors: Jeffrey N. Katz, Savannah R. Smith, Jamie E. Collins, Daniel H. Solomon, Joanne M. Jordan, David J. Hunter, Lisa G. Suter, Edward Yelin, A.David Paltiel, Elena Losina Source Type: research
Pharmacological Treatment of Acute Low Back Pain
This randomized trial compared improvement in functional outcomes among patients with low back pain discharged from the emergency department and receiving naproxen with either placebo, cyclobenzaprine, or oxycodone/acetaminophen. (Source: JAMA)
Source: JAMA - October 20, 2015 Category: Journals (General) Source Type: research
Molecules, Vol. 20, Pages 18585-18596: Green Synthesis of Novel Polyaniline Nanofibers: Application in pH Sensing
An optically active polyaniline nanomaterial (PANI-Nap), doped with (S)-naproxen, was developed and evaluated as a potent pH sensor. We synthesized the material in one pot by the addition of the dopant, (S)-naproxen, prior to polymerization, followed by the addition of the oxidizing agent (ammonium persulfate) that causes polymerization of the aniline. This green chemistry approach allowed us to take only 1 h to produce a water-soluble and stable nanomaterial. UV-visible spectroscopy, fluorescence spectroscopy, FT-IR spectroscopy, Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM...
Source: Molecules - October 13, 2015 Category: Chemistry Authors: Shivani TanwarJa-an Ho Tags: Article Source Type: research
Multi-residue enantiomeric analysis of human and veterinary pharmaceuticals and their metabolites in environmental samples by chiral liquid chromatography coupled with tandem mass spectrometry detection.
Abstract Enantiomeric profiling of chiral pharmacologically active compounds (PACs) in the environment has hardly been investigated. This manuscript describes, for the first time, a multi-residue enantioselective method for the analysis of human and veterinary chiral PACs and their main metabolites from different therapeutic groups in complex environmental samples such as wastewater and river water. Several analytes targeted in this paper have not been analysed in the environment at enantiomeric level before. These are aminorex, carboxyibuprofen, carprofen, cephalexin, 3-N-dechloroethylifosfamide, 10,11-dihydro-10-...
Source: Analytical and Bioanalytical Chemistry - October 13, 2015 Category: Chemistry Authors: Camacho-Muñoz D, Kasprzyk-Hordern B Tags: Anal Bioanal Chem Source Type: research
Validated HPLC-UV method for determination of naproxen in human plasma with proven selectivity against ibuprofen and paracetamol.
This article is protected by copyright. All rights reserved. PMID: 26458096 [PubMed - as supplied by publisher] (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - October 12, 2015 Category: Biomedical Science Authors: Filist M, Szlaska I, Kaza M, Pawiński T Tags: Biomed Chromatogr Source Type: research
Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers.
Abstract In this work, we introduce dipeptides containing tryptophan N-capped with the nonsteroidal anti-inflammatory drug naproxen and C-terminal dehydroamino acids, dehydrophenylalanine (ΔPhe), dehydroaminobutyric acid (ΔAbu), and dehydroalanine (ΔAla) as efficacious protease resistant hydrogelators. Optimized conditions for gel formation are reported. Transmission electron microscopy experiments revealed that the hydrogels consist of networks of micro/nanosized fibers formed by peptide self-assembly. Fluorescence and circular dichroism spectroscopy indicate that the self-assembly process is driven by stacking...
Source: Biomacromolecules - October 7, 2015 Category: Biochemistry Authors: Vilaça H, Hortelão AC, Castanheira EM, Queiroz MR, Hilliou L, Hamley IW, Martins JA, Ferreira PM Tags: Biomacromolecules Source Type: research
Abstract PR09: Intermittent dosing regimens maintain efficacy of several cancer preventing drugs
Many potential chemopreventive drugs have adverse effects on human subjects when given daily. One strategy to alleviate these adverse events is to give the drugs on an intermittent dosing schedule. Such intermittent dosing has proven effective in other settings to reduce toxicity with limited effect on efficacy. Two animal models were used: the rat methylnitrosourea (MNU) - induced mammary cancer model and the rat hydroxy-butyl(butyl)-nitrosamine (OH-BBN) -induced urinary bladder cancer model. For the mammary study female Sprague-Dawley rats were given 75 mg of MNU/kg body weight at 50 days of age and five days later the E...
Source: Cancer Prevention Research - October 2, 2015 Category: Cancer & Oncology Authors: Steele, V. E., Grubbs, C. J., Lubet, R. A. Tags: Biological Agents: Oral Presentations - Proffered Abstracts Source Type: research
Optical coherence tomography angiography and widefield fundus autofluorescence in punctate inner choroidopathy
Discussion: This is the first case report of optical coherence tomography angiography imaging of choroidal neovascularization associated with punctate inner choroidopathy and the first report of widefield FAF abnormalities in punctate inner choroidopathy. Optical coherence tomography angiography may provide a more noninvasive and sensitive imaging system for the evaluation of choroidal neovascularization than traditional fluorescein angiography and may provide a direct gauge of response to therapy. Widefield FAF may improve detection of inflammatory activity of retinal disease and monitoring of disease activity. (Source: R...
Source: Retinal Cases and Brief Reports - October 1, 2015 Category: Opthalmology Tags: Case Report Source Type: research
Prevalence, trends, patterns and associations of analgesic use in Germany
Conclusions: About one in five community dwelling adults aged 18–79 years in Germany use analgesics in a given week. Considering the potential harms of analgesic use, monitoring of prevalence, patterns and determinants of use at the population level are important steps to inform disease prevention and health promotion policies. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - October 1, 2015 Category: Drugs & Pharmacology Authors: Giselle SarganasAmanda ButteryWanli ZhuangIngrid-Katharina WolfDaniel GramsAngelika RosarioChrista Scheidt-NaveHildtraud Knopf Source Type: research
Electromembrane extraction using two separate cells: a new design for simultaneous extraction of acidic and basic compounds
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - October 1, 2015 Category: Biochemistry Authors: Saeed Nojavan, Sakine Asadi Tags: Research Paper Source Type: research
Solubility of Naproxen in Polyethylene Glycol 200 + Water Mixtures at Various Temperatures
The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban-Acree model + van’t Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree model with van’t Hoff equation can be used to predict solubility in PEG 200 + water with only four solubility data in mono-solvents. Theobtained solubility calculation errors vary from ~ 17 % up to 35 % depend on the numbe...
Source: Iranian Journal of Pharmaceutical Research - September 30, 2015 Category: Drugs & Pharmacology Source Type: research
Understanding thermodynamics of drug partitioning in micelles and delivery to proteins: Studies with naproxen, diclofenac sodium, tetradecyltrimethylammonium bromide, and bovine serum albumin
Publication date: January 2016 Source:The Journal of Chemical Thermodynamics, Volume 92 Author(s): Paurnima Talele, Sinjan Choudhary, Nand Kishore The use of surfactants in drug delivery has offered several advantages. Quantitative knowledge of the interactions of drugs with micellar systems is essential for deriving guidelines to design efficient drug delivery systems. In this work we have quantitatively addressed the mechanism of interaction of naproxen and diclofenac sodium with the micelles and monomers of tetradecyltrimethylammonium bromide (TTAB) based on thermodynamic studies by using isothermal titration calor...
Source: The Journal of Chemical Thermodynamics - September 29, 2015 Category: Chemistry Source Type: research
Single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews.
CONCLUSIONS: There is a wealth of reliable evidence on the analgesic efficacy of single dose oral analgesics. Fast acting formulations and fixed dose combinations of analgesics can produce good and often long-lasting analgesia at relatively low doses. There is also important information on drugs for which there are no data, inadequate data, or where results are unreliable due to susceptibility to publication bias. This should inform choices by professionals and consumers. PMID: 26414123 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 28, 2015 Category: Journals (General) Authors: Moore RA, Derry S, Aldington D, Wiffen PJ Tags: Cochrane Database Syst Rev Source Type: research
The conformational behaviour of naproxen and flurbiprofen in solution by NMR spectroscopy
New J. Chem., 2015, Accepted ManuscriptDOI: 10.1039/C5NJ01753J, PaperMaria Enrica Di Pietro, christie Aroulanda, Giorgio Celebre, Denis Merlet, Giuseppina De LucaNaproxen and flurbiprofen are among the most popular and widely used drugs for treating pain and inflammation and new different therapeutic uses are still proposed. Their pharmacological activity comes from...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - September 18, 2015 Category: Chemistry Authors: Maria Enrica Di Pietro Source Type: research
Oxidative stress, energy storage, and swimming performance of Limnodynastes peronii tadpoles exposed to a sub-lethal pharmaceutical mixture throughout development.
Abstract Pharmaceutical contaminants represent emerging threats to aquatic animals and ecosystem health, and research exploring toxicological outcomes associated with these compounds in non-target wildlife has been flagged for prioritization. Amphibians represent particularly vulnerable organisms and many populations around the world are currently at risk of extinction. However, to date, relatively few studies have explored the consequences of exposures to common non-steroidal pharmaceuticals during sensitive amphibian life-stages. To address existing knowledge gaps, tadpoles of the Australian striped-marsh frog (L...
Source: Chemosphere - September 18, 2015 Category: Chemistry Authors: Melvin SD Tags: Chemosphere Source Type: research
Tablets and minitablets prepared from spray-dried SMEDDS containing naproxen
Publication date: 10 November 2015 Source:International Journal of Pharmaceutics, Volume 495, Issue 1 Author(s): Katja Čerpnjak, Alenka Zvonar Pobirk, Franc Vrečer, Mirjana Gašperlin The purpose of this study was to compare different solidification techniques (i.e., adsorption technique, spray-drying process, high-shear granulation, fluid-bed granulation) for preparing solid SMEDDS powders by using solid carriers identified as appropriate and to produce a single (tablets) or multiunit (minitablets) solid dosage form based on prepared solid SMEDDS loaded with naproxen in a dissolved (6% w/w) or supersaturated (18% ...
Source: International Journal of Pharmaceutics - September 16, 2015 Category: Drugs & Pharmacology Source Type: research
Single nonsteroidal anti-inflammatory drug induced serum sickness-like reaction to naproxen in a patient able to tolerate both aspirin and ibuprofen
Publication date: Available online 3 September 2015 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Rebecca Koransky, Denisa Ferastraoaru, Elina Jerschow (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 3, 2015 Category: Allergy & Immunology Source Type: research
The effect of electric field geometry on the performance of electromembrane extraction systems: Footprints of a third driving force along with migration and diffusion.
Abstract The distribution of electric field vectors was first calculated for electromembrane extraction (EME) systems in classical and cylindrical electrode geometries. The results showed that supported liquid membrane (SLM) has a general field amplifying effect due to its lower dielectric constant in comparison with aqueous donor/acceptor solutions. The calculated norms of the electric field vector showed that a DC voltage of 50 V can create huge electric field strengths up to 64 kV m(-1) and 111 kV m(-1) in classical and cylindrical geometries respectively. In both cases, the electric field strength reached ...
Source: Analytica Chimica Acta - September 3, 2015 Category: Chemistry Authors: Moazami HR, Hosseiny Davarani SS, Mohammadi J, Nojavan S, Abrari M Tags: Anal Chim Acta Source Type: research
TiO2 photocatalysis of naproxen: Effect of the water matrix, anions and diclofenac on degradation rates.
This study demonstrates that competition for active sites (anions or DCF) and formation of multiple photoproducts resulting from synergistic interactions (between both APIs) are key to the TiO2-photocatalysed NPX degradation. PMID: 26340372 [PubMed - as supplied by publisher] (Source: Chemosphere)
Source: Chemosphere - September 1, 2015 Category: Chemistry Authors: Kanakaraju D, Motti CA, Glass BD, Oelgemöller M Tags: Chemosphere Source Type: research
Surfactant assisted electromembrane extraction combined with capillary electrophoresis as a novel technique for the determination of acidic drugs in biological fluids
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - September 1, 2015 Category: Biochemistry Authors: Ali Reza Fakhari, Kobra Sadat Hasheminasab, Zolfaghar Aladaghlo, Mohammad Hosein Koruni Tags: Research Paper Source Type: research
Onset and durability of pain relief in knee osteoarthritis: Pooled results from two placebo trials of naproxen/esomeprazole combination and celecoxib.
CONCLUSION: Naproxen/esomeprazole produced a significant absolute moderate early pain response, which was maintained for 12 weeks. RAPID3 was found to be highly correlated with the typical OA measure (WOMAC) and might be a useful clinical tool for measuring NSAID response. NCT00664560: https://clinicaltrials.gov/ct2/show/NCT00664560, NCT00665431: https://www.clinicaltrials.gov/ct2/show/NCT00665431. PMID: 26313454 [PubMed - as supplied by publisher] (Source: The Physician and Sportsmedicine Online)
Source: The Physician and Sportsmedicine Online - August 28, 2015 Category: Sports Medicine Tags: Phys Sportsmed Source Type: research
Drug Oxidation by Cytochrome P450BM3 : Metabolite Synthesis and Discovering New P450 Reaction Types.
Abstract There is intense interest in late-stage catalytic CH bond functionalization as an integral part of synthesis. Effective catalysts must have a broad substrate range and tolerate diverse functional groups. Drug molecules provide a good test of these attributes of a catalyst. A library of P450BM3 mutants developed from four base mutants with high activity for hydrocarbon oxidation produced human metabolites of a panel of drugs that included neutral (chlorzoxazone, testosterone), cationic (amitriptyline, lidocaine) and anionic (diclofenac, naproxen) compounds. No single mutant was active for all the tested ...
Source: Chemistry - August 27, 2015 Category: Chemistry Authors: Ren X, Yorke JA, Taylor E, Zhang T, Zhou W, Wong LL Tags: Chemistry Source Type: research
Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy
Conclusion: In conclusion, this study shows that NO donation may have an important role, in addition to anti-inflammatory activity, in slowing down the progression of the disease in the mdx mouse model therefore positioning naproxcinod as a promising candidate for treatment of DMD. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - August 22, 2015 Category: Internal Medicine Authors: Daniela MigliettaClara De PalmaClara ScioratiBarbara VerganiViviana PisaAntonello VillaEnnio OnginiEmilio Clementi Source Type: research
Resistance exercise and naproxen sodium: effects on a stable PGF 2α metabolite and morphological adaptations of the upper body appendicular skeleton
Conclusion Despite acute inhibition of the PGF2α metabolite at early time points, naproxen sodium did not hinder positive morphological adaptations of the upper body in response to resistance training. (Source: Inflammopharmacology)
Source: Inflammopharmacology - August 19, 2015 Category: Drugs & Pharmacology Source Type: research
Identification of in vitro and in vivo disconnects using transcriptomic data
Conclusion: The results confirmed that there are important discrepancies between in vitro and in vivo toxicogenomic experiments. However, the contribution of this paper is to provide a tool to identify genes that are disconnected between the two systems. Pathway analysis of disconnected genes may improve our understanding of uncertainties in the mechanism of actions of drug candidates in humans, especially concerning the early detection of toxicity. (Source: BMC Genomics)
Source: BMC Genomics - August 18, 2015 Category: Genetics & Stem Cells Authors: Martin OtavaZiv ShkedyWillem TalloenGeert VerheyenAdetayo Kasim Source Type: research
Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β.
Abstract VA694, a promising cyclooxigenase-2 (COX-2)-inhibiting hybrid drug endowed with nitric oxide (NO) releasing properties (NO-COXIB), showed COX-2-selective inhibitory effects, associated with interesting anti-inflammatory and anti-nociceptive activities. Therefore, we studied the effects of VA694 on cartilage metabolism, in comparison with Naproxcinod, a COX inhibitor and NO donor (CINOD), and Naproxen, a traditional non-steroidal-anti-inflammatory drug (NSAID) on human osteoarthritic chondrocyte cultures. IL-1β-stimulated chondrocytes showed a significant decrease in cell viability (P<0.001). VA694, Nap...
Source: International Immunopharmacology - August 17, 2015 Category: Allergy & Immunology Authors: Cheleschi S, Pascarelli NA, Valacchi G, Di Capua A, Biava M, Belmonte G, Giordani A, Sticozzi C, Anzini M, Fioravanti A Tags: Int Immunopharmacol Source Type: research
Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish (Danio rerio)
Publication date: September 2015 Source:Environmental Toxicology and Pharmacology, Volume 40, Issue 2 Author(s): V. Stancová, A. Ziková, Z. Svobodová, W. Kloas The aim of this study was to investigate the effects of naproxen on the gene expression of antioxidant enzymes in adult zebrafish. Surprisingly, after 2 weeks exposure no significant effect on the mRNA expression of the target genes was found in the liver. However, mRNA levels of three genes were altered significantly in the intestine. The expression of Ucp-2 decreased at the environmental concentration of 1μg/L while mRNA expression of GST p2 increased at...
Source: Environmental Toxicology and Pharmacology - August 16, 2015 Category: Environmental Health Source Type: research
Drop printing of pharmaceuticals: Effect of molecular weight on PEG coated‐naproxen/PEG 3350 solid dispersions
Solid dispersions have been used to enhance the bioavailability of poorly water‐soluble active pharmaceutical ingredients (APIs). However, the solid‐state phase, compositional uniformity, and scale‐up problems are issues that need to be addressed. To allow for highly controllable products, the drop printing (DP) technique can provide precise dosages and predictable compositional uniformity of APIs in two‐/three‐dimensional structures. DP was used to prepare naproxen (NAP)/polyethylene glycol 3350 (PEG 3350) solid dispersions with PEG coatings of different molecular weights (MWs). A comparison of moisture‐accele...
Source: AIChE Journal - August 14, 2015 Category: Science Authors: Hsin‐Yun Hsu, Michael T. Harris, Scott Toth, Garth J. Simpson Tags: Soft Matter: Synthesis, Processing and Products Source Type: research
Drop printing of pharmaceuticals: Effect of molecular weight on PEG coated‐naproxen/PEG3350 solid dispersions
This article is protected by copyright. All rights reserved. (Source: AIChE Journal)
Source: AIChE Journal - August 7, 2015 Category: Science Authors: Hsin‐Yun Hsu, Scott Toth, Garth J. Simpson, Michael T. Harris Tags: Soft Matter: Synthesis, Processing and Products Source Type: research
Structural modeling, in vitro antiproliferative activity, and the effect of substituents on the DNA fastening and scission actions of heteroleptic copper(II) complexes with terpyridines and naproxen
New J. Chem., 2015, Advance ArticleDOI: 10.1039/C5NJ01059D, PaperDharmasivam Mahendiran, Perumal Gurumoorthy, Krishnasamy Gunasekaran, Raju Senthil Kumar, Aziz Kalilur RahimanA new series of heteroleptic copper(II) complexes with terpyridines and naproxen are reported. The results of biological activity are laying a foundation for the design of new anticancer agents.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - August 6, 2015 Category: Chemistry Authors: Dharmasivam Mahendiran Source Type: research
Onset and durability of pain relief in knee osteoarthritis: pooled results from two placebo trials of naproxen/esomeprazole combination and celecoxib.
CONCLUSION: Naproxen/esomeprazole produced a significant absolute moderate early pain response, which was maintained for 12 weeks. RAPID3 was found to be highly correlated with the typical OA measure (WOMAC) and might be a useful clinical tool for measuring NSAID response. NCT00664560: https://clinicaltrials.gov/ct2/show/NCT00664560, NCT00665431: https://www.clinicaltrials.gov/ct2/show/NCT00665431. PMID: 26235613 [PubMed - as supplied by publisher] (Source: The Physician and Sportsmedicine Online)
Source: The Physician and Sportsmedicine Online - August 5, 2015 Category: Sports Medicine Tags: Phys Sportsmed Source Type: research
Diverse Ways of Perturbing the Human Arachidonic Acid Metabolic Network To Control Inflammation.
Abstract Inflammation and other common disorders including diabetes, cardiovascular disease, and cancer are often the result of several molecular abnormalities and are not likely to be resolved by a traditional single-target drug discovery approach. Though inflammation is a normal bodily reaction, uncontrolled and misdirected inflammation can cause inflammatory diseases such as rheumatoid arthritis and asthma. Nonsteroidal anti-inflammatory drugs including aspirin, ibuprofen, naproxen, or celecoxib are commonly used to relieve aches and pains, but often these drugs have undesirable and sometimes even fatal side eff...
Source: Cancer Control - August 3, 2015 Category: Cancer & Oncology Authors: Meng H, Liu Y, Lai L Tags: Acc Chem Res Source Type: research
Abstract 877: Aspirin and other nonsteroidal anti-inflammatory drugs, statins, and risk of non-Hodgkin lymphoma
Conclusions. We found a strong inverse association of low dose aspirin use with risk of NHL and the subtypes of DLBCL, FL, and MZL, but no association for regular/extra strength aspirin, other NSAIDs or statin use. While confirmation is needed, our findings for low dose aspirin but not use of other NSAIDs suggest that anti-platelet or other effects of low dose aspirin may be of etiologic significance in lymphomagenesis.Citation Format: James R. Cerhan, Megan M. O'Bryne, Grzegorz S. Nowakowski, Timothy G. Call, Carrie A. Thompson, Tait D. Shanafelt, William R. Macon, Neil E. Kay, Thomas M. Habermann, Susan L. Slager, Mark L...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Cerhan, J. R., O'Bryne, M. M., Nowakowski, G. S., Call, T. G., Thompson, C. A., Shanafelt, T. D., Macon, W. R., Kay, N. E., Habermann, T. M., Slager, S. L., Liebow, M. Tags: Epidemiology Source Type: research
Abstract 4502: Identification of an aspirin-derived small molecule as a potential therapeutic for colorectal cancer
In the US, colorectal cancer (CRC) remains the second leading cause of cancer-related death. The 5-year survival rate for patients with CRC is 64%, although for patients who present with distant metastases at diagnosis the 5 year survival is only 12%. Currently used standard care for CRC can only marginally extend the survival of patients and is associated with numerous adverse events. Hence, there remains an urgent need for more effective and less toxic treatments, which can increase CRC patient survival with better quality of life. Non-steroidal anti-inflammatory drugs (NSAIDs) (e.g. Aspirin, Ibuprofen, Naproxen), which ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Karelia, D., Pandey, M., Plano, D., Narayan, S., Jani, J., Sharma, J., Amin, S., Sharma, A. K. Tags: Experimental and Molecular Therapeutics Source Type: research
Acute Migraine Treatment
This article provides a systematic, evidence-based approach to acute medication choices for the patient with migraine. Recent Findings:: Recent clinical trials, meta-analyses, and practice guidelines have confirmed that four nonsteroidal anti-inflammatory drugs (NSAIDs) with randomized controlled trial evidence for efficacy in migraine (ibuprofen, naproxen sodium, diclofenac potassium, and acetylsalicylic acid) and seven triptans (sumatriptan, rizatriptan, eletriptan, zolmitriptan, almotriptan, frovatriptan, and naratriptan) are appropriate medications for acute migraine treatment. Dihydroergotamine (DHE) is also suitable ...
Source: CONTINUUM - August 1, 2015 Category: Neurology Tags: Review Articles Source Type: research
Separation and On‐line Preconcentration of Nonsteroidal Anti‐inflammatory Drugs by Microemulsion Electrokinetic Chromatography
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - August 1, 2015 Category: Biochemistry Authors: Chia‐Wen Chang, Yu‐Cheng Chen, Chuen‐Ying Liu Tags: Research Paper Source Type: research
Functional food property of honey locust (Gleditsia triacanthos) flowers
Publication date: October 2015 Source:Journal of Functional Foods, Volume 18, Part A Author(s): Chuan-Rui Zhang, Amila A. Dissanayake, Muraleedharan G. Nair The use of honey locust in food prompted us to study its flowers for functional food constituents. Bioassay-guided purification of hexane, ethyl acetate and methanolic extracts of its flowers afforded three new betulinic acid esters (1–3), one new linalool carboxylic acid ester (4), known terpenoids (5–7) and known polyphenols (8–11), as elucidated by spectroscopic methods. The extracts and terpenoids 1–7 were tested for antiinflammatory and antioxidant ac...
Source: Journal of Functional Foods - July 31, 2015 Category: Nutrition Source Type: research
Interventions for pain with intrauterine device insertion.
CONCLUSIONS: Nearly all trials used modern IUC. Most effectiveness evidence was of moderate quality, having come from single trials. Lidocaine 2% gel, misoprostol, and most NSAIDs did not help reduce pain. Some lidocaine formulations, tramadol, and naproxen had some effect on reducing IUC insertion-related pain in specific groups. The ineffective interventions do not need further research. PMID: 26222246 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - July 29, 2015 Category: Journals (General) Authors: Lopez LM, Bernholc A, Zeng Y, Allen RH, Bartz D, O'Brien PA, Hubacher D Tags: Cochrane Database Syst Rev Source Type: research
Structural modeling, in vitro antiproliferative activity, and effect of substituents on dna fastening and scission actions of heteroleptic copper(ii) complexes with terpyridines and naproxen drug
New J. Chem., 2015, Accepted ManuscriptDOI: 10.1039/C5NJ01059D, PaperKalilur Rahiman, Dharmasivam Mahendiran, Perumal Gurumoorthy, Gunasekaran krishnasamy, Senthil kumar RajuA series of heteroleptic copper(II) complexes of the type [Cu(L1-6)(nap)Cl] (1-6) (L1-6 = 4'-(4-substituted)-2,2':6',2''-terpyridines, nap = naproxen drug) have been synthesized and characterized. The single crystal analysis of complexes 1...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - July 24, 2015 Category: Chemistry Authors: Kalilur Rahiman Source Type: research
Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis).
CONCLUSIONS: High to moderate quality evidence indicates that both traditional and COX-2 NSAIDs are efficacious for treating axSpA, and moderate to low quality evidence indicates harms may not differ from placebo in the short term. Various NSAIDs are equally effective. Continuous NSAID use may reduce radiographic spinal progression, but this requires confirmation. PMID: 26186173 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - July 17, 2015 Category: Journals (General) Authors: Kroon FP, van der Burg LR, Ramiro S, Landewé RB, Buchbinder R, Falzon L, van der Heijde D Tags: Cochrane Database Syst Rev Source Type: research
A novel approach for predicting the dissolution profiles of pharmaceutical tablets.
Abstract In this paper, the intrinsic dissolution profiles of naproxen (NAP) at pH values of 1.5 and 3.0 and of trimethoprim (TMP) at pH values of 1.5, 3.0, 5.0, 6.5 and 7.2 were measured. Meanwhile, the dissolution profiles of NAP and TMP from cylindrical tablets were measured at different temperatures (298.15 K, 305.15 K, 301.15 K and 310.15 K) and stirring speeds (50 rpm, 100 rpm and 150 rpm) as well as at different pH values (1.5, 3.0, 5.0, 6.5 and 7.2). Additionally the pH-dependent solubilities of both APIs were measured and modeled. The chemical-potential-gradient model combined with the perturbed-chain stat...
Source: European Journal of Pharmaceutics and Biopharmaceutics - July 10, 2015 Category: Drugs & Pharmacology Authors: Paus R, Hart E, Ji Y Tags: Eur J Pharm Biopharm Source Type: research