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Impact of chirality on the photoinduced charge transfer in linked systems containing naproxen enantiomers
Phys. Chem. Chem. Phys., 2016, Advance ArticleDOI: 10.1039/C5CP07305G, PaperE. A. Khramtsova, D. V. Sosnovsky, A. A. Ageeva, E. Nuin, M. L. Marin, P. A. Purtov, S. S. Borisevich, S. L. Khursan, H. D. Roth, M. A. Miranda, V. F. Plyusnin, T. V. LeshinaThe model reaction of photoinduced electron transfer in dyads has been used to compare the reactivity of anti-inflammatory drug, (S)-naproxen and its (R)-isomer.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 21, 2016 Category: Chemistry Authors: E. A. Khramtsova Source Type: research

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults.
CONCLUSIONS: The conclusions of this review were not changed. Combination treatment was effective in the acute treatment of migraine headaches. The effect was greater than for the same dose of either sumatriptan or naproxen alone, but additional benefits over sumatriptan alone were not large. More participants achieved good relief when medication was taken early in the attack, when pain was still mild. Adverse events were more common with the combination and sumatriptan alone than with placebo or naproxen alone. PMID: 27096438 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 20, 2016 Category: Journals (General) Authors: Law S, Derry S, Moore RA Tags: Cochrane Database Syst Rev Source Type: research

Molecules, Vol. 21, Pages 509: Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage
In this study, the behavior of the recently identified sodium naproxen-lactose-tetrahydrate co-crystal and the co-amorphous mixture of sodium, naproxen, and lactose was investigated. The structure of the co-crystal is described using single-crystal X-ray diffraction. The structural analysis revealed a monoclinic lattice, space group P21, with the asymmetric unit containing one molecule of lactose, one of naproxen, sodium, and four water molecules. Upon heating, it was observed that the co-crystal transforms into a co-amorphous system due to the loss of its crystalline bound water. Dehydration and co-amorphization were stud...
Source: Molecules - April 19, 2016 Category: Chemistry Authors: Ioana SovagoWenbo WangDanwen QiuDhara RaijadaJukka RantanenHolger GrohganzThomas RadesAndrew BondKorbinian Löbmann Tags: Article Source Type: research

Drugs for the acute treatment of migraine in children and adolescents.
CONCLUSIONS: Low quality evidence from two small trials shows that ibuprofen appears to improve pain freedom for the acute treatment of children with migraine. We have only limited information on adverse events associated with ibuprofen in the trials included in this review. Triptans as a class are also effective at providing pain freedom in children and adolescents but are associated with higher rates of minor adverse events. Sumatriptan plus naproxen sodium is also effective in treating adolescents with migraine. PMID: 27091010 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 19, 2016 Category: Journals (General) Authors: Richer L, Billinghurst L, Linsdell MA, Russell K, Vandermeer B, Crumley ET, Durec T, Klassen TP, Hartling L Tags: Cochrane Database Syst Rev Source Type: research

Molecules, Vol. 21, Pages 420: Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives
The current study focuses on the synthesis of several hybrid individuals combining a natural oleanolic acid skeleton and synthetic nonsteroidal anti-inflammatory drug moieties (NSAIDs). It studied structural modifications of the oleanolic acid structure by use of the direct reactivity of hydroxyl or hydroxyimino groups at position C-3 of the triterpenoid skeleton with the carboxylic function of anti-inflammatory drugs leading to new perspective compounds with high potential pharmacological activities. Novel ester- and iminoester-type derivatives of oleanolic unit with the different NSAIDs, such as ibuprofen, aspirin, napro...
Source: Molecules - April 12, 2016 Category: Chemistry Authors: Anna PawełczykDorota OlenderKatarzyna Sowa-KasprzakLucjusz Zaprutko Tags: Article Source Type: research

Impact of Chirality on the Photo-Induced Charge Transfer in Linked Systems Containing Naproxen Enantiomers.
Phys. Chem. Chem. Phys., 2016, Accepted ManuscriptDOI: 10.1039/C5CP07305G, PaperEkaterina Andreevna Khramtsova, Denis Viktorovich Sosnovsky, Alexandra Andreevna Ageeva, Edurne Nuin, Maria Luisa Marin, Petr A. Purtov, Sophia S. Borisevich, Sergey L. Khursan, Heinz Roth, Miguel Miranda, Victor F. Plyusnin, Tatyana LeshinaThe model reaction, the photo-induced donor-acceptor interaction in linked systems - dyads, have been used to study the comparative reactivity of a well-known anti-inflammatory drug, (S)-naproxen (NPX) and its (R)-isomer....The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. ...
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 11, 2016 Category: Chemistry Authors: Ekaterina Andreevna Khramtsova Source Type: research

Fixed Drug Eruption Due to Selective Hypersensitivity to Naproxen with Tolerance to other Propionic Acid NSAIDs.
CONCLUSION: In our patient PT confirmed the diagnosis and allowed us to study the cross-reactivity between NSAIDs of the same group, and confirmed by SBOCT. Cross-reactivity between propionic acid derivatives was studied. This is a case of hypersensitivity to naproxen with good tolerance to other propionic acids NSAIDs (ibuprofen and ketoprofen) and nabumetone, confirmed by PT and SBOCT. Some relavent patents for fixed drug eruption are discussed. PMID: 27041368 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - April 7, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Experimental and theoretical study of molecular interactions between 2-vinyl pyridine and acidic pharmaceuticals used as multi-template molecules in molecularly imprinted polymer
In this study, a multi-template molecularly imprinted polymer (MIP) for ibuprofen, naproxen and diclofenac was synthesized in an oil bath set at 70 °C for 24 hours. 2-vinyl pyridine, ethylene glycol dimethacrylate, toluene and 1,1’-azobis-(cyclohexanecarbonitrile) were used as functional monomer, cross-linker, porogen and radical initiator, respectively. A non-imprinted polymer (NIP) was synthesized using a similar approach with the omission of templates. Monomer-template interactions were examined using Molecular Dynamics and Fourier Transform Infrared Spectroscopy (FTIR). Both molecular dynamics and FT-IR results indi...
Source: Reactive and Functional Polymers - April 3, 2016 Category: Chemistry Source Type: research

Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) like meclofenamate sodium (MS), used to reduce pain, has been associated with an increased risk of cardiovascular disease (CVD). Naproxen (NAP), another NSAID, is not associated with increased risk of CVD. The molecular mechanism(s) by which NSAIDs induce CVD is unknown.We investigated the effects of MS and NAP on protein homeostasis and cardiotoxicity in rat cardiac H9c2 cells and murine neonatal cardiomyocytes.MS, but not NAP, significantly inhibited proteasome activity and reduced cardiac cell viability at pharmacological levels found in humans. (Source: Journal o...
Source: Journal of Molecular and Cellular Cardiology - April 3, 2016 Category: Cytology Authors: Rajeshwary Ghosh, Soyun M. Hwang, Ziyou Cui, Jennifer E. Gilda, Aldrin V. Gomes Source Type: research

Conservative treatment of acute knee osteoarthritis: A review of the Cochrane Library
Conclusions Five main strategies for the conservative treatment of knee osteoarthritis exist that must be used before indicating surgical treatment: medical treatment, physical medicine and rehabilitation, intra-articular injections, acupuncture, and self-management education programs. (Source: Journal of Acute Disease)
Source: Journal of Acute Disease - April 2, 2016 Category: Emergency Medicine Source Type: research

Octadecylamine-Mediated Versatile Coating of CoFe2O4 NPs for the Sustained Release of Anti-Inflammatory Drug Naproxen and in Vivo Target Selectivity
ACS Applied Materials & InterfacesDOI: 10.1021/acsami.6b00408 (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - March 29, 2016 Category: Materials Science Authors: Violetta Georgiadou, George Makris, Dionysia Papagiannopoulou, Georgios Vourlias and Catherine Dendrinou-Samara Source Type: research

Development and validation of an LC-ESI-MS/MS method for the simultaneous quantification of naproxen and sumatriptan in human plasma: application to a pharmacokinetic study.
Abstract A sensitive and fast liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for the simultaneous quantification of naproxen and sumatriptan in human plasma. A simple liquid-liquid extraction procedure, with a mixture of ethyl acetate, methyl tert-butyl ether, and dichloromethane (4:3:3, v/v), was used for the cleanup of plasma. Naratriptan and aceclofenac were employed as internal standards. The analyses were carried out using an ACE C18 column (50 × 4.6 mm i.d.; particle size 5 μm) and a mobile phase consisting of 2 mM aqueous ammo...
Source: Analytical and Bioanalytical Chemistry - March 28, 2016 Category: Chemistry Authors: Brêtas JM, César IC, Brêtas CM, Teixeira LS, Bellorio KB, Mundim IM, Pianetti GA Tags: Anal Bioanal Chem Source Type: research

Course of active inflammatory and fatty lesions in patients with early axial spondyloarthritis treated with infliximab plus naproxen as compared to naproxen alone: Results from the INFAST study
Conclusion. Effective anti‐inflammatory treatment of axSpA was associated with an increase in fatty lesion scores that was independent of the treatment arm. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 25, 2016 Category: Rheumatology Authors: Denis Poddubnyy, Joachim Listing, Joachim Sieper Tags: Brief Report Source Type: research

Hydroxy double salts loaded with bioactive ions: Synthesis, intercalation mechanisms, and functional performance
Publication date: June 2016 Source:Journal of Solid State Chemistry, Volume 238 Author(s): Abdessamad Y. A. Kaassis, Si-Min Xu, Shanyue Guan, David G. Evans, Min Wei, Gareth R. Williams The intercalation of the anions of diclofenac (Dic), naproxen (Nap), and valproic acid (Val) into three hydroxy double salts (HDSs) has been explored in this work. Experiments were performed with [Co1.2Zn3.8(OH)8](NO3)2·2H2O (CoZn-NO3), [Ni2Zn3(OH)8](NO3)2·2H2O (NiZn-NO3) and [Zn5(OH)8](NO3)2·2H2O (Zn-NO3). It proved possible to intercalate diclofenac and naproxen into all three HDSs. In contrast, Val could be intercalated into C...
Source: Journal of Solid State Chemistry - March 22, 2016 Category: Chemistry Source Type: research

Mesoporous silica based MCM-41 as solid-phase extraction sorbent combined with micro-liquid chromatography-quadrupole-mass spectrometry for the analysis of pharmaceuticals in waters.
Abstract This paper reports the first application of the silica based mesoporous material MCM-41 as a sorbent in solid phase extraction, to pre-concentrate pharmaceuticals of very different polarity (atenolol, nadolol, pindolol, timolol, bisoprolol, metoprolol, betaxolol, ketoprofen, naproxen, ibuprofen, diclofenac, tolfenamic acid, flufenamic acid and meclofenamic acid) in surface waters. The analytes were extracted from 100mL water samples at pH 2.0 (containing 10(-3)mol/L of sodium chloride) by passing the solution through a cartridge filled with 100mg of MCM-41. Following elution, the pharmaceuticals were deter...
Source: Talanta - March 20, 2016 Category: Chemistry Authors: Dahane S, Martínez Galera M, Marchionni ME, Socías Viciana MM, Derdour A, Gil García MD Tags: Talanta Source Type: research

Coatings of molecularly imprinted polymers based on polyhedral oligomeric silsesquioxane for open tubular capillary electrochromatography.
Abstract Polyhedral oligomeric silsesquioxane (POSS) was successfully applied, for the first time, to prepare imprinted monolithic coating for capillary electrochromatography. The imprinted monolithic coating was synthesized with a mixture of PSS-(1-Propylmethacrylate)-heptaisobutyl substituted (MA 0702), S-amlodipine (template), methacrylic acid (functional monomer), and 2-methacrylamidopropyl methacrylate (crosslinker), in a porogenic mixture of toluene-isooctane. The influence of synthesis parameters on the imprinting effect and separation performance, including the amount of MA 0702, the ratio of template to mo...
Source: Talanta - March 20, 2016 Category: Chemistry Authors: Zhao QL, Zhou J, Zhang LS, Huang YP, Liu ZS Tags: Talanta Source Type: research

Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis
Publication date: Available online 18 March 2016 Source:The Lancet Author(s): Bruno R da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Jüni, Sven Trelle Background Non-steroidal anti-inflammatory drugs (NSAIDs) are the backbone of osteoarthritis pain management. We aimed to assess the effectiveness of different preparations and doses of NSAIDs on osteoarthritis pain in a network meta-analysis. Methods For this network meta-analysis, we considered randomised trials comparing any of the following interventions: NSAIDs, paracetamol, or placebo, for the treatment of osteoarthritis pain. ...
Source: The Lancet - March 18, 2016 Category: Journals (General) Source Type: research

Sonocatalytic removal of naproxen by synthesized zinc oxide nanoparticles on montmorillonite.
Abstract ZnO/MMT nanocomposite as sonocatalyst was prepared by immobilizing synthesized ZnO on the montmorillonite surface. The characteristics of as-prepared nanocomposite were studied by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM) and X-ray diffraction (XRD) techniques. The synthesized samples were used as a catalyst for sonocatalytic degradation of naproxen. ZnO/MMT catalyst in the presence of ultrasound irradiation was more effective compared to pure ZnO nanoparticles and MMT particles in the sonocatalysis of naproxen. The effect of different operational paramet...
Source: Ultrasonics Sonochemistry - March 13, 2016 Category: Chemistry Authors: Karaca M, Kıranşan M, Karaca S, Khataee A, Karimi A Tags: Ultrason Sonochem Source Type: research

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report
Conclusions This is the first reported case, to the best of our knowledge, of the detection of a secondary malignant giant cell tumor of bone based on fever of unknown origin after long-term (40 years) follow-up. After curettage and bone grafting, giant cell tumor of bone may transform to malignancies within a few years or even decades after surgery. Therefore, meticulous follow-up is essential. The fever might be attributable to the tumor releasing inflammatory cytokines. Not only pain and swelling but also continuous pyrexia may suggest the diagnosis of a secondary malignant giant cell tumor of bone. (Source: ...
Source: Journal of Medical Case Reports - March 8, 2016 Category: Journals (General) Source Type: research

A Strategy for Co-former Selection to Design Stable Co-amorphous Formations Based on Physicochemical Properties of Non-steroidal Inflammatory Drugs
Conclusions The results showed a relationship between stable co-amorphous formation and the physicochemical features of the components, which should inform efficient co-former selection to design stable co-amorphous formations. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2016 Category: Drugs & Pharmacology Source Type: research

Gastrointestinal safety, chemotherapeutic potential, and classic pharmacological profile of NOSH‐naproxen (AVT‐219) a dual NO‐ and H2S‐releasing hybrid
Abstract Naproxen (NAP) is a potent nonsteroidal anti‐inflammatory drug (NSAID) with a favorable cardiovascular profile. However, its long‐term use may lead to serious gastrointestinal and renal side effects. NOSH‐ (nitric oxide and hydrogen sulfide) releasing naproxen (NOSH‐NAP, AVT‐219) belongs to a new class of anti‐inflammatory agents designed to overcome these limitations. We compared the gastrointestinal safety, anti‐inflammatory, analgesic, antipyretic, and antiplatelet properties of AVT‐219 to that of NAP in preclinical animal models. We also evaluated its anticancer effects in 11 human cancer cell ...
Source: Pharmacology Research and Perspectives - March 4, 2016 Category: Drugs & Pharmacology Authors: Mitali Chattopadhyay, Ravinder Kodela, Pascale L. Duvalsaint, Khosrow Kashfi Tags: Original Article Source Type: research

Effect of NSAIDs on the aminopeptidase activity of cultured human osteoblasts
The objective was to determine the effect of certain NSAIDs on the AP activity of osteoblasts. Primary cultures of osteoblast were treated with different concentrations of indomethacin, meloxicam, naproxen, nimesulide, and piroxicam. The AP activity was fluorimetrically determined using aminoacyl-β-naphthylamides (aa-βNAs) as substrates: Ala-βNA, Arg-βNA, Gly-βNA, Leu-βNA, Lys-βNA, Met-βNA, and Phe-βNA. The five NSAIDs showed an inhibitory effect of AP activity against the study substrates depending on the dose tested. Meloxicam and piroxicam had the highest inhibitory effect on enzymatic activity, with an IC50 of...
Source: Molecular and Cellular Endocrinology - February 28, 2016 Category: Endocrinology Source Type: research

Novel Naproxen/esomeprazole magnesium compound pellets based on acid-independent mechanism: In vitro and in vivo evaluation.
Authors: Lu J, Kan S, Zhao Y, Zhang W, Liu J Abstract The purpose of this study was to develop the novel Naproxen/Esomeprazole magnesium compound pellets (novel-NAP/EMZ) depending on EMZ acid-independent mechanism which has been proved to be predominate in the mechanism of co-therapy with non-steroidal anti-inflammatory drug. The novel-NAP/EMZ compound pellets, composed of NAP colon-specific pellets (NAP-CSPs) and EMZ modified-release pellets (EMZ-MRPs), were prepared by fluid-bed coating technology with desired in vitro release profiles. The resulting pellets were filled into hard gelatin capsules for in vivo eval...
Source: Drug Development and Industrial Pharmacy - February 25, 2016 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

1: comparative effect of selective and non-selective cox-2 inhibitors on lipid accumulation in human macrophages
Conclusions Here we report that only specific COX-2 inhibitors might contribute to atherogenesis by promoting lipid overload and lipoprotein accumulation. This may explain, in part, the increased CV risk in patients taking COX-2 inhibitors for extended periods. Despite increased scavenger receptor expression, naproxen and acetaminophen do not impact lipid content, perhaps because efflux pathways remain intact. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - February 25, 2016 Category: Research Authors: Kasselman, L., Voloshyna, I., Littlefield, M., Siegart, N., Carsons, S., Gomolin, I., De Leon, J., Reiss, A. Tags: Scientific Session I, 8:30 AM - 10:30 AM, Wednesday, April 13, 2016 Source Type: research

Modeling and predicting the influence of variable factors on dissolution of crystalline pharmaceuticals
Publication date: 12 May 2016 Source:Chemical Engineering Science, Volume 145 Author(s): Raphael Paus, Yuanhui Ji In this work, the dissolution profiles of different crystalline active pharmaceutical ingredients (APIs), which show a diverse water solubility (paracetamol>hydrochlorothiazide>trimethoprim>naproxen>indomethacin>cinnarizine) were measured in water at different temperatures and stirring speeds using a rotating disk system. Meanwhile, the dissolution mechanism of these APIs was analyzed by using a two-step chemical-potential-gradient model. The solubilities and activity coef...
Source: Chemical Engineering Science - February 19, 2016 Category: Chemistry Source Type: research

Efficacy of single-dose, extended-release naproxen sodium 660 mg in postsurgical dental pain: two double-blind, randomized, placebo-controlled trials.
CONCLUSIONS: A single dose of ER naproxen sodium 660 mg significantly reduced moderate to severe dental pain vs. placebo and was comparable to IR naproxen sodium 220 mg tid. Significant pain relief was experienced from 15 min and sustained over 24 h, resulting in a reduced need for rescue medication. ER naproxen sodium 660 mg once daily is a convenient and effective therapy providing 24 h relief of pain. PMID: 26588111 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Indomethacin inhibits tetrodotoxin-resistant Na(+) channels at acidic pH in rat nociceptive neurons.
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are well-known inhibitors of cyclooxygenases (COXs) and are widely used for the treatment of inflammatory pain; however several NSAIDs display COX-independent analgesic action including the inhibition of voltage-gated Na(+) channels expressed in primary afferent neurons. In the present study, we examined whether NSAIDs modulate tetrodotoxin-resistant (TTX-R) Na(+) channels and if this modulation depends on the extracellular pH. The TTX-R Na(+) currents were recorded from small-sized trigeminal ganglion neurons by using a whole-cell patch clamp technique. Among...
Source: Neuropharmacology - February 17, 2016 Category: Drugs & Pharmacology Authors: Nakamura M, Jang IS Tags: Neuropharmacology Source Type: research

In acute low back pain, adding oxycodone/acetaminophen or cyclobenzaprine to naproxen did not improve pain or function.
PMID: 26882304 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - February 16, 2016 Category: Internal Medicine Authors: Carpenter CR Tags: Ann Intern Med Source Type: research

Carbon dioxide mediated vasomotion of extra-cranial cerebral arteries in humans: A role for prostaglandins?
This article is protected by copyright. All rights reserved. PMID: 26880615 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 16, 2016 Category: Physiology Authors: Hoiland RL, Tymko MM, Bain AR, Wildfong KW, Monteleone B, Ainslie PN Tags: J Physiol Source Type: research

Competitive binding of anticancer drugs 5-fluorouracil and cyclophosphamide with serum albumin: Calorimetric insights
This article is part of a Special Issue entitled Microcalorimetry in the BioSciences — Principles and Applications, edited by Fadi Bou-Abdallah. Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 15, 2016 Category: Biochemistry Source Type: research

Naproxen Alone May Be Best for Acute Low Back Pain.
PMID: 26926822 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - February 15, 2016 Category: Primary Care Authors: Slawson D Tags: Am Fam Physician Source Type: research

The Pharmacology of Indomethacin.
CONCLUSIONS: NSAIDs easily enter the brain, but their high protein binding limits absolute amount of entry. All work similarly as either nonselective or selective cyclooxygenase inhibitors, but indomethacin may have more potent vasoconstrictive activity and unique direct neuronal or nitric oxide-dependent inhibitory pathway activity. PMID: 26865183 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - February 11, 2016 Category: Neurology Authors: Lucas S Tags: Headache Source Type: research

Sorption of diclofenac and naproxen onto MWCNT in model wastewater treated by H2O2 and/or UV.
Abstract The application of oxidation processes such as UV and/or H2O2 will change the physicochemical properties of carbon nanotubes (CNT). It may affect the sorption affinity of CNT to different contaminants and then affect their fate in the environment. In the present study the adsorption of two very common used pharmaceuticals (diclofenac and naproxen) onto CNT treated by UV, H2O2 or UV/H2O2 was investigated. Four different adsorption models (Freundlich, Langmuir, Temkin, Dubinin-Radushkevich) were tested. The best fitting of experimental data was observed for Freundlich or Langmuir model. The significant relat...
Source: Chemosphere - February 8, 2016 Category: Chemistry Authors: Czech B, Oleszczuk P Tags: Chemosphere Source Type: research

Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae)
Conclusions C. pulverulents exerts moderate cytotoxic effects in human cancer cells, moderate anti-inflammatory and antinociceptive effects. C. pulverulentus induces antinociceptive effects without inducing sedation. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 6, 2016 Category: Drugs & Pharmacology Source Type: research

Competitive binding of anticancer drugs 5-fluorouracil and cyclophosphamide with serum albumin: Calorimetric insights.
This article is part of a Special Issue entitled Microcalorimetry in the BioSciences - Principles and Applications, edited by Fadi Bou-Abdallah. PMID: 26854955 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 6, 2016 Category: Biochemistry Authors: Thoppil AA, Choudhary S, Kishore N Tags: Biochim Biophys Acta Source Type: research

Chiral Separation of Naproxen with Immobilized Liquid Phases
Organic Process Research & DevelopmentDOI: 10.1021/acs.oprd.6b00020 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - February 5, 2016 Category: Chemistry Authors: Sandra Corderí, Caecilia R. Vitasari, Michal Gramblicka, Thierry Giard and Boelo Schuur Source Type: research

Automated evaluation of protein binding affinity of anti-inflammatory choline based ionic liquids.
Abstract In this work, an automated system for the study of the interaction of drugs with human serum albumin (HSA) was developed. The methodology was based on the quenching of the intrinsic fluorescence of HSA by binding of the drug to one of its binding sites. The fluorescence quenching assay was implemented in a sequential injection analysis (SIA) system and the optimized assay was applied to ionic liquids based on the association of non-steroidal anti-inflammatory drugs with choline (IL-API). In each cycle, 100µL of HSA and 100µL of IL-API (variable concentration) were aspirated at a flow rate of 1mLmin(-1) a...
Source: Talanta - February 4, 2016 Category: Chemistry Authors: Ribeiro R, Pinto PC, Azevedo AM, Bica K, Ressmann AK, Reis S, Saraiva ML Tags: Talanta Source Type: research

Synthesis of Amino-ADT Provides Access to Hydrolytically Stable Amide-Coupled Hydrogen Sulfide Releasing Drug Targets
SynlettDOI: 10.1055/s-0035-1560603As additional physiological functions of hydrogen sulfide (H2S) are discovered, developing practical methods for exogenous H2S delivery is important. In particular, nonsteroidal anti-inflammatory drugs (NSAIDs) functionalized with H2S-releasing anethole dithiolethione (ADT-OH) through ester bonds are being investigated for their combined anti-inflammatory and antioxidant potential. The chemical robustness of the connection between drug and H2S-delivery components, however, is a key and controllable linkage in these compounds. Because esters are susceptible to hydrolysis, particularly under...
Source: Synlett - February 4, 2016 Category: Chemistry Authors: Hammers, Matthew D.Singh, LovepritMontoya, Leticia A.Moghaddam, Alan D.Pluth, Michael D. Tags: letter Source Type: research

Immediate hypersensitivity reactions to ibuprofen and other arylpropionic acid derivatives
ConclusionsWithin the group of patients with HDRs to NSAIDs, APs can induce immediate SRs. Within this group, selective responses to a single drug or responders to several APs may exist, suggesting potential immunological cross‐reactivity.This article is protected by copyright. All rights reserved. (Source: Allergy)
Source: Allergy - February 3, 2016 Category: Allergy & Immunology Authors: Natalia Blanca‐López, Diana Pérez‐Alzate, Inmaculada Andreu, Inmaculada Doña, José Augusto Agúndez, Elena García‐Martín, María Salas, Miguel Ángel Miranda, María José Torres, José Antonio Cornejo‐García, Miguel Blanca, Gabriela Canto Tags: Original Article: Skin and Eye Diseases Source Type: research

[Comparison of the postoperative analgesic effects of naproxen sodium and naproxen sodium-codeine phosphate for arthroscopic meniscus surgery].
CONCLUSIONS: The combination of naproxen sodium-codeine phosphate provided more effective analgesia than naproxen sodium and did not increase side effects. PMID: 26832827 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)
Source: Revista Brasileira de Anestesiologia - February 3, 2016 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

Nonsteroidal Antiinflammatory Drugs for Axial Spondyloarthritis: A Cochrane Review.
CONCLUSION: High-quality evidence indicates that both traditional and COX-2 NSAID are efficacious for treating axSpA, and harms are not different from placebo in the short term. Various NSAID are equally effective. PMID: 26834216 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2016 Category: Rheumatology Authors: Kroon FP, van der Burg LR, Ramiro S, Landewé RB, Buchbinder R, Falzon L, van der Heijde D Tags: J Rheumatol Source Type: research

Introduction of high nitrogen doped graphene as a new cationic carrier in electro membrane extraction
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - February 1, 2016 Category: Biochemistry Authors: Atefe Atarodi, Mahmoud Chamsaz, Ali Zeraatkar Moghaddam, Hadi Tabani Tags: Research Paper Source Type: research

A working model for the assessment of disruptions in social behavior among aged rats: The role of sex differences, social recognition, and sensorimotor processes.
In this study, both males and females exhibited late aging-related reductions in social interactions, but these changes were more pronounced in females. Additionally, sensorimotor performance was shown to be impaired in 24-month-olds, but not 18-month-olds, with this deficit more evident in males. Finally, Exp. 3 examined whether aging-related inflammation could account for declines in social behavior during late aging by administering naproxen (0, 7, 14, and 28mg/kg; s.c.)-a non-steroidal anti-inflammatory drug-to 18-month-old females. Results from this study revealed that social behavior was unaffected by acute or repeat...
Source: Experimental Gerontology - January 23, 2016 Category: Geriatrics Authors: Perkins AE, Doremus-Fitzwater TL, Spencer RL, Varlinskaya EI, Conti MM, Bishop C, Deak T Tags: Exp Gerontol Source Type: research

Removal rates of antibiotics in four sewage treatment plants in South India.
Abstract The occurrence and removal of seven selected pharmaceutical compounds (PCs) in sewage treatment plants (STPs) in South India were investigated. The PCs selected for this study were sulfamethoxazole (SMX), trimethoprim (TMP), chloramphenicol (CAP), erythromycin (ERY), naproxen (NPX), bezafibrate (BZF), and ampicillin (AMP). Wastewater samples were collected from inlet and outlet of the STPs during pre-monsoon, monsoon, and post-monsoon seasons to investigate the seasonal influences in occurrence and removal rates. The analytical method was based on simultaneous extraction of all target compounds by solid ph...
Source: Environmental Science and Pollution Research International - January 22, 2016 Category: Environmental Health Authors: Prabhasankar VP, Joshua DI, Balakrishna K, Siddiqui IF, Taniyasu S, Yamashita N, Kannan K, Akiba M, Praveenkumarreddy Y, Guruge KS Tags: Environ Sci Pollut Res Int Source Type: research

Acute Treatment Therapies for Pediatric Migraine: A Qualitative Systematic Review
ConclusionsOf the available evidence, ibuprofen, prochlorperazine, and certain triptan medications are the most effective and safe agents for acute management of migraine and other benign headache disorders in the pediatric population. Additional studies in this population are needed, and should take into consideration variables such as dosing, co‐administered medications, treatment duration, and length of treatment effect. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - January 21, 2016 Category: Neurology Authors: Irene R. Patniyot, Amy A. Gelfand Tags: Review Article Source Type: research

Oxidative stress indices and histopathological effects of the nonsteroidal antiinflammatory drug naproxen in adult zebrafish (Danio rerio).
CONCLUSION: This study demonstrates that the environmental concentration of naproxen can slightly influence both the antioxidant defense system and histopathology of non-target fish. PMID: 26757123 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - January 15, 2016 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The Influence of Efflux Pump Inhibitors on the Activity of Non-Antibiotic NSAIDS against Gram-Negative Rods
Conclusions The effects of PAβN on the susceptibility of bacteria to NSAIDs indicate that some NSAIDs are substrates for efflux pumps in Gram-negative rods. Morever, Aspirin probably induced efflux-mediated resistance to fluoroquinolones in a few E. coli strains. (Source: PLoS One)
Source: PLoS One - January 15, 2016 Category: Biomedical Science Authors: Agnieszka E. Laudy et al. Source Type: research

Widespread occurrence and seasonal variation of pharmaceuticals in surface waters and municipal wastewater treatment plants in central Finland.
In conclusion, there are considerable amounts of pharmaceuticals not only in influents and effluents of the WWTPs but also in lake water along the waterway and in northern Lake Päijänne. PMID: 26769590 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - January 15, 2016 Category: Environmental Health Authors: Lindholm-Lehto PC, Ahkola HS, Knuutinen JS, Herve SH Tags: Environ Sci Pollut Res Int Source Type: research

Protective Effect of 4-(3, 4-Dihydroxyphenyl)-3-buten-2-one from Phellinus linteus on Naproxen-induced Gastric Antral Ulcers in Rats.
Abstract The present study was investigated the protective effect of naturally purified 4-(3, 4-dihydroxyphenyl)-3-buten-2-one (DHP) from Phellinus linteus against naproxen-induced gastric antral ulcers in rats. To verify the protective effect of DHP on naproxen-induced gastric antral ulcers, various doses (1, 5, and 10 µg/kg) of DHP were pretreated for 3 days, and then gastric damage was caused by 80 mg/kg naproxen applied for 3 days. DHP prevented naproxen-induced gastric antral ulcers in a dose-dependent manner. Especially, 10 µg/kg DHP showed the best protective effect against naproxen-induced gastric antral ...
Source: Journal of Microbiology and Biotechnology - January 15, 2016 Category: Biotechnology Authors: Kim JH, Kwon HJ, Kim BW Tags: J Microbiol Biotechnol Source Type: research

Relative efficacy and tolerability of etoricoxib, celecoxib, and naproxen in the treatment of osteoarthritis : A Bayesian network meta-analysis of randomized controlled trials based on patient withdrawal.
CONCLUSIONS: Etoricoxib 30-60 mg, celecoxib 200-400 mg, and naproxen 1000 mg were more efficacious than placebo. However, there was no significant difference in efficacy and tolerability between the medications. PMID: 26768273 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - January 14, 2016 Category: Rheumatology Authors: Song GG, Seo YH, Kim JH, Choi SJ, Ji JD, Lee YH Tags: Z Rheumatol Source Type: research