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Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae)
Conclusions C. pulverulents exerts moderate cytotoxic effects in human cancer cells, moderate anti-inflammatory and antinociceptive effects. C. pulverulentus induces antinociceptive effects without inducing sedation. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 6, 2016 Category: Drugs & Pharmacology Source Type: research

Competitive binding of anticancer drugs 5-fluorouracil and cyclophosphamide with serum albumin: Calorimetric insights.
This article is part of a Special Issue entitled Microcalorimetry in the BioSciences - Principles and Applications, edited by Fadi Bou-Abdallah. PMID: 26854955 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 6, 2016 Category: Biochemistry Authors: Thoppil AA, Choudhary S, Kishore N Tags: Biochim Biophys Acta Source Type: research

Chiral Separation of Naproxen with Immobilized Liquid Phases
Organic Process Research & DevelopmentDOI: 10.1021/acs.oprd.6b00020 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - February 5, 2016 Category: Chemistry Authors: Sandra Corderí, Caecilia R. Vitasari, Michal Gramblicka, Thierry Giard and Boelo Schuur Source Type: research

Automated evaluation of protein binding affinity of anti-inflammatory choline based ionic liquids.
Abstract In this work, an automated system for the study of the interaction of drugs with human serum albumin (HSA) was developed. The methodology was based on the quenching of the intrinsic fluorescence of HSA by binding of the drug to one of its binding sites. The fluorescence quenching assay was implemented in a sequential injection analysis (SIA) system and the optimized assay was applied to ionic liquids based on the association of non-steroidal anti-inflammatory drugs with choline (IL-API). In each cycle, 100µL of HSA and 100µL of IL-API (variable concentration) were aspirated at a flow rate of 1mLmin(-1) a...
Source: Talanta - February 4, 2016 Category: Chemistry Authors: Ribeiro R, Pinto PC, Azevedo AM, Bica K, Ressmann AK, Reis S, Saraiva ML Tags: Talanta Source Type: research

Synthesis of Amino-ADT Provides Access to Hydrolytically Stable Amide-Coupled Hydrogen Sulfide Releasing Drug Targets
SynlettDOI: 10.1055/s-0035-1560603As additional physiological functions of hydrogen sulfide (H2S) are discovered, developing practical methods for exogenous H2S delivery is important. In particular, nonsteroidal anti-inflammatory drugs (NSAIDs) functionalized with H2S-releasing anethole dithiolethione (ADT-OH) through ester bonds are being investigated for their combined anti-inflammatory and antioxidant potential. The chemical robustness of the connection between drug and H2S-delivery components, however, is a key and controllable linkage in these compounds. Because esters are susceptible to hydrolysis, particularly under...
Source: Synlett - February 4, 2016 Category: Chemistry Authors: Hammers, Matthew D.Singh, LovepritMontoya, Leticia A.Moghaddam, Alan D.Pluth, Michael D. Tags: letter Source Type: research

Immediate hypersensitivity reactions to ibuprofen and other arylpropionic acid derivatives
ConclusionsWithin the group of patients with HDRs to NSAIDs, APs can induce immediate SRs. Within this group, selective responses to a single drug or responders to several APs may exist, suggesting potential immunological cross‐reactivity.This article is protected by copyright. All rights reserved. (Source: Allergy)
Source: Allergy - February 3, 2016 Category: Allergy & Immunology Authors: Natalia Blanca‐López, Diana Pérez‐Alzate, Inmaculada Andreu, Inmaculada Doña, José Augusto Agúndez, Elena García‐Martín, María Salas, Miguel Ángel Miranda, María José Torres, José Antonio Cornejo‐García, Miguel Blanca, Gabriela Canto Tags: Original Article: Skin and Eye Diseases Source Type: research

[Comparison of the postoperative analgesic effects of naproxen sodium and naproxen sodium-codeine phosphate for arthroscopic meniscus surgery].
CONCLUSIONS: The combination of naproxen sodium-codeine phosphate provided more effective analgesia than naproxen sodium and did not increase side effects. PMID: 26832827 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)
Source: Revista Brasileira de Anestesiologia - February 3, 2016 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

Nonsteroidal Antiinflammatory Drugs for Axial Spondyloarthritis: A Cochrane Review.
CONCLUSION: High-quality evidence indicates that both traditional and COX-2 NSAID are efficacious for treating axSpA, and harms are not different from placebo in the short term. Various NSAID are equally effective. PMID: 26834216 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2016 Category: Rheumatology Authors: Kroon FP, van der Burg LR, Ramiro S, Landewé RB, Buchbinder R, Falzon L, van der Heijde D Tags: J Rheumatol Source Type: research

Introduction of high nitrogen doped graphene as a new cationic carrier in electro membrane extraction
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - February 1, 2016 Category: Biochemistry Authors: Atefe Atarodi, Mahmoud Chamsaz, Ali Zeraatkar Moghaddam, Hadi Tabani Tags: Research Paper Source Type: research

A working model for the assessment of disruptions in social behavior among aged rats: The role of sex differences, social recognition, and sensorimotor processes.
In this study, both males and females exhibited late aging-related reductions in social interactions, but these changes were more pronounced in females. Additionally, sensorimotor performance was shown to be impaired in 24-month-olds, but not 18-month-olds, with this deficit more evident in males. Finally, Exp. 3 examined whether aging-related inflammation could account for declines in social behavior during late aging by administering naproxen (0, 7, 14, and 28mg/kg; s.c.)-a non-steroidal anti-inflammatory drug-to 18-month-old females. Results from this study revealed that social behavior was unaffected by acute or repeat...
Source: Experimental Gerontology - January 23, 2016 Category: Geriatrics Authors: Perkins AE, Doremus-Fitzwater TL, Spencer RL, Varlinskaya EI, Conti MM, Bishop C, Deak T Tags: Exp Gerontol Source Type: research

Removal rates of antibiotics in four sewage treatment plants in South India.
Abstract The occurrence and removal of seven selected pharmaceutical compounds (PCs) in sewage treatment plants (STPs) in South India were investigated. The PCs selected for this study were sulfamethoxazole (SMX), trimethoprim (TMP), chloramphenicol (CAP), erythromycin (ERY), naproxen (NPX), bezafibrate (BZF), and ampicillin (AMP). Wastewater samples were collected from inlet and outlet of the STPs during pre-monsoon, monsoon, and post-monsoon seasons to investigate the seasonal influences in occurrence and removal rates. The analytical method was based on simultaneous extraction of all target compounds by solid ph...
Source: Environmental Science and Pollution Research International - January 22, 2016 Category: Environmental Health Authors: Prabhasankar VP, Joshua DI, Balakrishna K, Siddiqui IF, Taniyasu S, Yamashita N, Kannan K, Akiba M, Praveenkumarreddy Y, Guruge KS Tags: Environ Sci Pollut Res Int Source Type: research

Acute Treatment Therapies for Pediatric Migraine: A Qualitative Systematic Review
ConclusionsOf the available evidence, ibuprofen, prochlorperazine, and certain triptan medications are the most effective and safe agents for acute management of migraine and other benign headache disorders in the pediatric population. Additional studies in this population are needed, and should take into consideration variables such as dosing, co‐administered medications, treatment duration, and length of treatment effect. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - January 21, 2016 Category: Neurology Authors: Irene R. Patniyot, Amy A. Gelfand Tags: Review Article Source Type: research

Oxidative stress indices and histopathological effects of the nonsteroidal antiinflammatory drug naproxen in adult zebrafish (Danio rerio).
CONCLUSION: This study demonstrates that the environmental concentration of naproxen can slightly influence both the antioxidant defense system and histopathology of non-target fish. PMID: 26757123 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - January 15, 2016 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The Influence of Efflux Pump Inhibitors on the Activity of Non-Antibiotic NSAIDS against Gram-Negative Rods
Conclusions The effects of PAβN on the susceptibility of bacteria to NSAIDs indicate that some NSAIDs are substrates for efflux pumps in Gram-negative rods. Morever, Aspirin probably induced efflux-mediated resistance to fluoroquinolones in a few E. coli strains. (Source: PLoS One)
Source: PLoS One - January 15, 2016 Category: Biomedical Science Authors: Agnieszka E. Laudy et al. Source Type: research

Widespread occurrence and seasonal variation of pharmaceuticals in surface waters and municipal wastewater treatment plants in central Finland.
In conclusion, there are considerable amounts of pharmaceuticals not only in influents and effluents of the WWTPs but also in lake water along the waterway and in northern Lake Päijänne. PMID: 26769590 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - January 15, 2016 Category: Environmental Health Authors: Lindholm-Lehto PC, Ahkola HS, Knuutinen JS, Herve SH Tags: Environ Sci Pollut Res Int Source Type: research

Protective Effect of 4-(3, 4-Dihydroxyphenyl)-3-buten-2-one from Phellinus linteus on Naproxen-induced Gastric Antral Ulcers in Rats.
Abstract The present study was investigated the protective effect of naturally purified 4-(3, 4-dihydroxyphenyl)-3-buten-2-one (DHP) from Phellinus linteus against naproxen-induced gastric antral ulcers in rats. To verify the protective effect of DHP on naproxen-induced gastric antral ulcers, various doses (1, 5, and 10 µg/kg) of DHP were pretreated for 3 days, and then gastric damage was caused by 80 mg/kg naproxen applied for 3 days. DHP prevented naproxen-induced gastric antral ulcers in a dose-dependent manner. Especially, 10 µg/kg DHP showed the best protective effect against naproxen-induced gastric antral ...
Source: Journal of Microbiology and Biotechnology - January 15, 2016 Category: Biotechnology Authors: Kim JH, Kwon HJ, Kim BW Tags: J Microbiol Biotechnol Source Type: research

Relative efficacy and tolerability of etoricoxib, celecoxib, and naproxen in the treatment of osteoarthritis : A Bayesian network meta-analysis of randomized controlled trials based on patient withdrawal.
CONCLUSIONS: Etoricoxib 30-60 mg, celecoxib 200-400 mg, and naproxen 1000 mg were more efficacious than placebo. However, there was no significant difference in efficacy and tolerability between the medications. PMID: 26768273 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - January 14, 2016 Category: Rheumatology Authors: Song GG, Seo YH, Kim JH, Choi SJ, Ji JD, Lee YH Tags: Z Rheumatol Source Type: research

Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists
Publication date: Available online 11 January 2016 Source:Life Sciences Author(s): Mire Zloh, Noelia Perez-Diaz, Leslie Tang, Pryank Patel, Louise Mackenzie Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. Aims Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen to bind to nuclear receptors. Materials and methods In silico screening predicted that both diclofenac and celecoxib has the potential to bind to a number of different nuclear receptors; docking analysis confirmed a theoretical ability for ...
Source: Life Sciences - January 13, 2016 Category: Biology Source Type: research

Efficacy and safety of etoricoxib compared with NSAIDs in acute gout: a systematic review and a meta-analysis
Abstract The aim is to study the efficacy and safety of etoricoxib in the treatment of acute gout, as compared with non-steroidal anti-inflammatory drugs (NSAIDs). We conducted a computerized search of electronic databases: PubMed, EMBASE, Web of Science, China Biology Medicine disc, and Cochrane Library. The search terms were as follows: gout arthritis, tophus, etoricoxib, indometacin naproxen, diclofenac, and NSAIDs. Articles were searched from 1983 until August 2014. A manual search of peer-reviewed English documents was performed by cross-checking the bibliographies of selected studies. These trials reported ...
Source: Clinical Rheumatology - January 1, 2016 Category: Rheumatology Source Type: research

Acute Treatment Therapies for Pediatric Migraine: A Qualitative Systematic Review.
CONCLUSIONS: Of the available evidence, ibuprofen, prochlorperazine, and certain triptan medications are the most effective and safe agents for acute management of migraine and other benign headache disorders in the pediatric population. Additional studies in this population are needed, and should take into consideration variables such as dosing, co-administered medications, treatment duration, and length of treatment effect. PMID: 26790849 [PubMed - in process] (Source: Headache)
Source: Headache - January 1, 2016 Category: Neurology Authors: Patniyot IR, Gelfand AA Tags: Headache Source Type: research

A High-Performance Thin Layer Chromatography (HPTLC) Method for Simultaneous Determination of Diphenhydramine Hydrochloride and Naproxen Sodium in Tablets.
Abstract A rapid and simple high-performance thin layer chromatography (HPTLC) method with densitometry at 230 nm was developed and validated for simultaneous determination of diphenhydramine hydrochloride (DPH) and naproxen sodium (NPS) from pharmaceutical preparation. The separation was carried out on aluminum plates precoated with silica gel 60 F254 using mobile phase toluene:methanol:glacial acetic acid (7.5:1:0.2, v/v/v). The linearity range lies between 200 and 1200 ng/band for DPH and 1760 and 10,560 ng/band for NPS with correlation coefficients of 0.994 and 0.995, respectively. The R f value for DPH is 0.20 ...
Source: Analytical Chemistry Insights - December 26, 2015 Category: Chemistry Authors: Bhole RP, Shinde SS, Chitlange SS, Wankhede SB Tags: Anal Chem Insights Source Type: research

Structural Insights into the Competitive Binding of Diclofenac and Naproxen by Equine Serum Albumin
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5b00909 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 23, 2015 Category: Chemistry Authors: Bartosz Sekula and Anna Bujacz Source Type: research

Pharmacological Modulation of Lung Carcinogenesis in Smokers: Preclinical and Clinical Evidence
Publication date: Available online 23 December 2015 Source:Trends in Pharmacological Sciences Author(s): Silvio De Flora, Gancho Ganchev, Marietta Iltcheva, Sebastiano La Maestra, Rosanna T. Micale, Vernon E. Steele, Roumen Balansky Many drugs in common use possess pleiotropic properties that make them capable of interfering with carcinogenesis mechanisms. We discuss here the ability of pharmacological agents to mitigate the pulmonary carcinogenicity of mainstream cigarette smoke. The evaluated agents include anti-inflammatory drugs (budesonide, celecoxib, aspirin, naproxen, licofelone), antidiabetic drugs (metfor...
Source: Trends in Pharmacological Sciences - December 23, 2015 Category: Drugs & Pharmacology Source Type: research

Functionalized β-cyclodextrin based potentiometric sensor for naproxen determination
Publication date: 1 April 2016 Source:Materials Science and Engineering: C, Volume 61 Author(s): Joanna Lenik, Renata Łyszczek Potentiometric sensors based on neutral β-cyclodextrins: (2-hydroxypropyl)-β-cyclodextrin, heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, heptakis(2,3,6-tri-O-benzoyl)-β-cyclodextrin and anionic β-cyclodextrin: (2-hydroxy-3-N,N,N-trimethylamino)propyl-β-cyclodextrin chloride for naproxen are described. Inclusion complexes of naproxen with the above-mentioned cyclodextrins were studied using IR spectroscopy. The electrode surface was made from PVC membranes doped with the appropriate β-cyc...
Source: Materials Science and Engineering: C - December 21, 2015 Category: Materials Science Source Type: research

130P * In-depth mechanistic study of a newly synthesized non-platinum-naproxen complex as an anti-cancer agent
(Source: Annals of Oncology)
Source: Annals of Oncology - December 19, 2015 Category: Cancer & Oncology Authors: Deb, J., Lakshman, T. R., Paine, T. K., Jana, S. S. Tags: Developmental therapeutics Source Type: research

Hip Arthroscopy and Heterotopic Ossification: Is NSAID Prophylaxis Justified?: Commentary on an article by James T. Beckmann, MD, MS, et al.: "Effect of Naproxen Prophylaxis on Heterotopic Ossification Following Hip Arthroscopy: A Double-Blind Randomized Placebo-Controlled Trial"
(Source: The Journal of Bone and Joint Surgery)
Source: The Journal of Bone and Joint Surgery - December 16, 2015 Category: Orthopaedics Authors: Loken, S. Tags: Hip, Sports Medicine Commentary and Perspective Source Type: research

Effect of Naproxen Prophylaxis on Heterotopic Ossification Following Hip Arthroscopy: A Double-Blind Randomized Placebo-Controlled Trial
Conclusions: In this trial, prophylaxis with naproxen was effective in reducing the prevalence of HO without medication-related morbidity. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence. (Source: The Journal of Bone and Joint Surgery)
Source: The Journal of Bone and Joint Surgery - December 16, 2015 Category: Orthopaedics Authors: Beckmann, J. T., Wylie, J. D., Potter, M. Q., Maak, T. G., Greene, T. H., Aoki, S. K. Tags: Hip, Sports Medicine Scientific Articles Source Type: research

Behaviour of pharmaceuticals and personal care products in constructed wetland compartments: Influent, effluent, pore water, substrate and plant roots.
Abstract Seven mesocosm-scale constructed wetlands (CWs) with different design configurations, dealing with primary-treated urban wastewater, were assessed for the concentration, distribution and fate of ten pharmaceutical and personal care products (PPCPs) [ibuprofen, ketoprofen, naproxen, diclofenac, salicylic acid, caffeine, carbamazepine, methyl dihydrojasmonate, galaxolide and tonalide] and eight of their transformation products (TPs). Apart from influent and effluent, various CW compartments were analysed, namely, substrate, plant roots and pore water. PPCP content in pore water depended on the specific CW co...
Source: Chemosphere - December 15, 2015 Category: Chemistry Authors: Hijosa-Valsero M, Reyes-Contreras C, Domínguez C, Bécares E, Bayona JM Tags: Chemosphere Source Type: research

Coordination Polymers Derived from Non-Steroidal Anti-Inflammatory Drugs for Cell Imaging and Drug Delivery.
Abstract A new series of Mn(II) coordination polymers, namely, [{Mn(L)(H2 O)2 }⋅2 Nap]∞ (CP1), [{Mn(L)(Ibu)2 (H2 O)2 }]∞ (CP2), [{Mn(L)(Flr)2 (H2 O)2 }]∞ (CP3), [{Mn(L)(Ind)2 (H2 O)2 }⋅H2 O]∞ (CP4), [{Mn2 (L)2 (μ-Flu)4 (H2 O)}⋅L]∞ (CP5), [{Mn2 (L)2 (μ-Tol)4 (H2 O)2 }]∞ (CP6) and [{Mn2 (L)2 (μ-Mef)4 (H2 O)2 }]∞ (CP7) (Nap=naproxen, Ibu=ibuprofen, Flr=flurbiprofen, Ind=indometacin, Flu=flufenamic acid, Tol=tolfenamic acid and Mef=mefenamic acid) derived from various non-steroidal anti-inflammatory drugs (NSAIDs) and the organic linker 1,2-bis(4-pyridyl)ethylene (L) have been synthesized with ...
Source: Chemistry - December 11, 2015 Category: Chemistry Authors: Paul M, Dastidar P Tags: Chemistry Source Type: research

Low field photo-CIDNP in the intramolecular electron transfer of naproxen-pyrrolidine dyads
Phys. Chem. Chem. Phys., 2016, Advance ArticleDOI: 10.1039/C5CP04233J, PaperI. M. Magin, N. E. Polyakov, A. I. Kruppa, P. A. Purtov, T. V. Leshina, A. S. Kiryutin, M. A. Miranda, E. Nuin, M. L. MarinLow field dyad 1H CIDNP in low and high solvent polarity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - December 10, 2015 Category: Chemistry Authors: I. M. Magin Source Type: research

Molecules, Vol. 20, Pages 22028-22043: Efficient Synthesis of β-Aryl-γ-lactams and Their Resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen
An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride. (Source: Molecules)
Source: Molecules - December 10, 2015 Category: Chemistry Authors: Iris Montoya-BalbásBerenice Valentín-GuevaraEstefanía López-MendozaIrma Linzaga-ElizaldeMario OrdoñezPerla Román-Bravo Tags: Article Source Type: research

Rat paw oedema modeling and NSAIDs: Timing of effects.
CONCLUSIONS: Single-dose administration of naproxen (15 mg/kg) or indomethacin (10 mg/kg) exerts decrease in rat paw oedema volume at no later than 5 hours after oedema induction by carrageenan. Evaluating anti-inflammatory activity by the areas under the curve «increase in paw volume - time» proves that a single-dose NSAID's administration has no effect on the inflammatory response when evaluated not by single time-point index (at 3 or 5 hours), but by assessing the oedema development and duration over 192 hours (8 days). PMID: 26639722 [PubMed - in process] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - December 9, 2015 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Envisaging the Regulation of Alkaloid Biosynthesis and Associated Growth Kinetics in Hairy Roots of Vinca minor Through the Function of Artificial Neural Network.
Abstract Artificial neural network based modeling is a generic approach to understand and correlate different complex parameters of biological systems for improving the desired output. In addition, some new inferences can also be predicted in a shorter time with less cost and labor. As terpenoid indole alkaloid pathway in Vinca minor is very less investigated or elucidated, a strategy of elicitation with hydroxylase and acetyltransferase along with incorporation of various precursors from primary shikimate and secoiridoid pools via simultaneous employment of cyclooxygenase inhibitor was performed in the hairy roots...
Source: Applied Biochemistry and Biotechnology - December 3, 2015 Category: Biochemistry Authors: Verma P, Anjum S, Khan SA, Roy S, Odstrcilik J, Mathur AK Tags: Appl Biochem Biotechnol Source Type: research

Improvement of catalytic activity of Candida rugosa lipase in the presence of calix[4]arene bearing iminodicarboxylic/phosphonic acid complexes modified iron oxide nanoparticles.
Abstract In the present study, iron oxide magnetite nanoparticles, prepared through a co-precipitation method, were coated with phosphonic acid or iminodicarboxylic acid derivatives of calix[4]arene to modulate their surfaces with different acidic groups. Candida rugosa lipase was then directly immobilized onto the modified nanoparticles through sol-gel encapsulation. The catalytic activities and enantioselectivities of the two encapsulated lipases in the hydrolysis reaction of (R/S)-naproxen methyl ester and (R/S)-2-phenoxypropionic acid methyl ester were assessed. The results showed that the activity and enantios...
Source: Bioorganic Chemistry - December 2, 2015 Category: Chemistry Authors: Ozyilmaz E, Bayrakci M, Yilmaz M Tags: Bioorg Chem Source Type: research

Sumatriptan/Naproxen Sodium: A Review in Migraine
Abstract Sumatriptan/naproxen sodium (Treximet®) is a fixed-dose combination of a serotonin 5-HT1B/1D receptor agonist (sumatriptan) and an NSAID (naproxen sodium), approved in the USA for the acute treatment of migraine with or without aura in adolescents and adults. In a randomized, phase 3 trial in adolescents, significantly more sumatriptan/naproxen sodium than placebo recipients were pain-free at 2 h. Similarly, in a pair of randomized phase 3 trials in adults, significantly more sumatriptan/naproxen sodium than placebo recipients had relief from migraine symptoms at 2 h, and the combination was more effec...
Source: Drugs - December 1, 2015 Category: Drugs & Pharmacology Source Type: research

Design, Synthesis and In Vitro Release Studies of Co-drugs for Rheumatoid Arthritis.
Abstract Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammation that may affect many tissues and organs, but principally the synovial joints. The tendency for joint destruction is greatest in the early stages of disease hence current trend is to introduce a disease-modifying anti-rheumatic drug (DMARD) immediately after the diagnosis of RA in a step- up approach which is generally followed by its combination with a corticosteroid or NSAID. DMARD suppresses inflammatory activity over a long time-frame thus improving day to day function, and also prevents, lessens or delay...
Source: Inflammation and Allergy Drug Targets - December 1, 2015 Category: Allergy & Immunology Authors: Kashmira P, Suneela D, Shakuntalah C, Poorvashree J Tags: Inflamm Allergy Drug Targets Source Type: research

Analgesic efficacy of oral gabapentin added to standard epidural corticosteroids in patients with failed back surgery.
CONCLUSION: It was concluded that addition of oral gabapentin to epidural corticosteroid application in patients with failed back surgery syndromes was effective in ameliorating pain at an early stage without significant side effects. PMID: 22291506 [PubMed] (Source: Clinical Pharmacology: Advances and Applications)
Source: Clinical Pharmacology: Advances and Applications - November 29, 2015 Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research

Modulation by aspirin and naproxen of nucleotide alterations and tumors in the lung of mice exposed to environmental cigarette smoke since birth
Chemoprevention provides an important strategy for cancer control in passive smokers. Due to the crucial role played by smoke-related chronic inflammation in lung carcinogenesis, of special interest are extensively used pharmacological agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs). We evaluated the ability of aspirin and naproxen, inhibitors of both cyclooxygenase-1 and cyclooxygenase -2, to modulate environmental cigarette smoke (ECS)-induced lung carcinogenesis in A/J mice of both genders. Based on a subchronic toxicity study in 180 postweaning mice, we used 1600mg/kg diet aspirin and 320mg/kg diet naprox...
Source: Carcinogenesis - November 28, 2015 Category: Cancer & Oncology Authors: La Maestra, S., DAgostini, F., Izzotti, A., Micale, R. T., Mastracci, L., Camoirano, A., Balansky, R., Trosko, J. E., Steele, V. E., De Flora, S. Tags: Original Manuscript Source Type: research

Prevalence, trends, patterns and associations of analgesic use in Germany.
CONCLUSIONS: About one in five community dwelling adults aged 18-79 years in Germany use analgesics in a given week. Considering the potential harms of analgesic use, monitoring of prevalence, patterns and determinants of use at the population level are important steps to inform disease prevention and health promotion policies. PMID: 26428626 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 20, 2015 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Low field photo-CIDNP in the intramolecular electron transfer in naproxen-pyrrolidine dyads.
Phys. Chem. Chem. Phys., 2015, Accepted ManuscriptDOI: 10.1039/C5CP04233J, PaperIlya M Magin, Alexandr I. Kruppa, Nikolay Polyakov, Petr A. Purtov, Tatyana Leshina, Alexey S. Kiryutin, Maria Luisa Marin, Miguel Miranda, Edurne NuinPhotoinduced processes with partial (exciplex) and full charge transfer in donor-acceptor systems are of interest due to they are frequently used for modeling drug - protein binding. Low field photo...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - November 20, 2015 Category: Chemistry Authors: Ilya M Magin Source Type: research

Gastrointestinal damage by non-steroidal anti-inflammatory drugs: updated clinical considerations.
Authors: Pellicano R Abstract Gastrointestinal (GI) damage by non-steroidal anti-inflammatory drugs (NSAIDs) is an important Public Health problem due to morbility and elevated mortality rate. The logic behind the development and sale of molecules which are selective cyclooxegnase-2 (COX-2) inhibitors called coxibs, is to limit the undesired effects of traditional NSAIDs, which should theoretically derive from the inhibition of COX-1. With respect to the emphasis of the initial trials, to now epidemiological studies, open-label studies, meta-analyses and reviews of the same data with longer follow-up, have produced...
Source: Minerva Gastroenterologica e Dietologica - November 18, 2015 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Cardiovascular risk associated with celecoxib or etoricoxib: a meta-analysis of randomized controlled trials which adopted comparison with placebo or naproxen.
CONCLUSION: On the basis of our meta-analysis, we can state that symptomatic benefits induced by the prolonged administration of celecoxib may be partially invalidated by a concomitant increase in vascular risk, particularly the increased risk of myocardial infarction found in celecoxib-treated patients, compared to controls taking placebo. In contrast, treatment with etoricoxib proved not to result in an increased risk of serious vascular events when compared with both the placebo and naproxen. Our meta-analysis also denotes that the alternative to COXIBs, represented by naproxen, does not show significant benefit in term...
Source: Minerva Cardioangiologica - November 18, 2015 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research

Factors influencing naproxen metabolite interference in total bilirubin assays.
CONCLUSION: The acidic pH of diazo-based Dbil assay reagents inhibits the reaction of ODMN with diazo salts. The AU JG Tbil assay is a reliable method to measure Tbil in the setting of naproxen overdose. PMID: 26589001 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 14, 2015 Category: Biochemistry Authors: Saifee NH, Ranjitkar P, Greene DN Tags: Clin Biochem Source Type: research

Single‐drop microextraction combined in‐line with capillary electrophoresis for the determination of non‐steroidal anti‐inflammatory drugs in urine samples
This study describes a method to determine non‐steroidal anti‐inflammatory drugs in urine samples based on the use of single drop microextraction (SDME) in a three‐phase design as a preconcentration technique coupled in‐line to capillary electrophoresis. Different parameters affecting the extraction efficiency of the SDME process were evaluated (e.g. type of extractant, volume of the microdroplet and extraction time). The developed method was successfully applied to the analysis of human urine samples with LODs ranging between 1.0 and 2.5 μg/mL for all of the NSAIDs under study. This method shows RSD values rangin...
Source: Electrophoresis - November 4, 2015 Category: Biochemistry Authors: A. García‐Vázquez, F. Borrull, M. Calull, C. Aguilar Tags: Research Article Source Type: research

Surfactant‐assisted electromembrane extraction combined with capillary electrophoresis as a novel technique for the determination of acidic drugs in biological fluids
In this paper, for the first time, surfactant‐assisted electromembrane extraction coupled with capillary electrophoresis with UV detector was introduced for the extraction of acidic drugs from biological fluids. In this technique, in the presence of the nonionic surfactant in the donor phase, tendency of analyte ions into the supported liquid membrane (SLM) was increased. Naproxen and diclofenac were selected as model acidic drugs. In order to obtain the best extraction efficiency, several factors influencing the extraction efficiency were investigated. Optimal extractions were accomplished with 1‐octanol as the SLM, 1...
Source: Electrophoresis - November 3, 2015 Category: Biochemistry Authors: Ali Reza Fakhari, Kobra Sadat Hasheminasab, Zolfaghar Aladaghlo, Mohammad Hosein Koruni Tags: Research Article Source Type: research

Comparison of the postoperative analgesic effects of paracetamol–codeine phosphate and naproxen sodium–codeine phosphate for lumbar disk surgery
Publication date: September 2015 Source:The Kaohsiung Journal of Medical Sciences, Volume 31, Issue 9 Author(s): Reyhan Polat, Kevser Peker, Çiğdem Topçu Gülöksüz, Julide Ergil, Taylan Akkaya The aim of this study was to compared the efficacy of paracetamol–codeine phosphate and naproxen sodium–codeine phosphate on postoperative pain and tramadol consumption during the first 24 hours after a lumbar disk surgery. After Ethics Committee approval and informed consent had been obtained, 64 patients were allocated into three groups. Patients received oral paracetamol–codeine (300 mg + 30 mg; Group P), nap...
Source: The Kaohsiung Journal of Medical Sciences - October 31, 2015 Category: Universities & Medical Training Source Type: research

Molecules, Vol. 20, Pages 19571-19587: Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin
To benefit from the optimized dissolution properties of active pharmaceutical ingredients in their amorphous forms, co-amorphisation as a viable tool to stabilize these amorphous phases is of both academic and industrial interest. Reports dealing with the physical stability and recrystallization behavior of co-amorphous systems are however limited to qualitative evaluations based on the corresponding X-ray powder diffractograms. Therefore, the objective of the study was to develop a quantification model based on X-ray powder diffractometry (XRPD), followed by a multivariate partial least squares regression approach that en...
Source: Molecules - October 27, 2015 Category: Chemistry Authors: Andreas BeyerHolger GrohganzKorbinian LöbmannThomas RadesClaudia Leopold Tags: Article Source Type: research

Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities
To evaluate long-term clinical and economic outcomes of naproxen, ibuprofen, celecoxib or tramadol for OA patients with cardiovascular disease (CVD) and diabetes. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 22, 2015 Category: Rheumatology Authors: Jeffrey N. Katz, Savannah R. Smith, Jamie E. Collins, Daniel H. Solomon, Joanne M. Jordan, David J. Hunter, Lisa G. Suter, Edward Yelin, A.David Paltiel, Elena Losina Source Type: research

Pharmacological Treatment of Acute Low Back Pain
This randomized trial compared improvement in functional outcomes among patients with low back pain discharged from the emergency department and receiving naproxen with either placebo, cyclobenzaprine, or oxycodone/acetaminophen. (Source: JAMA)
Source: JAMA - October 20, 2015 Category: Journals (General) Source Type: research

Molecules, Vol. 20, Pages 18585-18596: Green Synthesis of Novel Polyaniline Nanofibers: Application in pH Sensing
An optically active polyaniline nanomaterial (PANI-Nap), doped with (S)-naproxen, was developed and evaluated as a potent pH sensor. We synthesized the material in one pot by the addition of the dopant, (S)-naproxen, prior to polymerization, followed by the addition of the oxidizing agent (ammonium persulfate) that causes polymerization of the aniline. This green chemistry approach allowed us to take only 1 h to produce a water-soluble and stable nanomaterial. UV-visible spectroscopy, fluorescence spectroscopy, FT-IR spectroscopy, Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM...
Source: Molecules - October 13, 2015 Category: Chemistry Authors: Shivani TanwarJa-an Ho Tags: Article Source Type: research