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Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes
This report presents data on the interaction of the most consumed NSAIDs (ibuprofen, naproxen and diclofenac) with one main phospholipid in eukaryotic cells, dimyristoylphosphatidylserine (DMPS). The applied techniques are Fourier-transform infrared spectroscopy (FTIR), with which in transmission the gel to liquid crystalline phase transition of the acyl chains in the absence and presence of the NSAID are monitored, supplemented by differential scanning calorimetry (DSC) data on the phase transition. FTIR in reflection (ATR, attenuated total reflectance) is applied to record the dependence of the interactions of the NSAID ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - June 28, 2016 Category: Biochemistry Source Type: research

Accessing the Physical State and Molecular Mobility of Naproxen Confined to Nanoporous Silica Matrixes
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.6b04078 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - June 24, 2016 Category: Chemistry Authors: Teresa Cordeiro, Andreia F. M. Santos, Guilherme Nunes, Guilherme Cunha, João C. Sotomayor, Isabel M. Fonseca, Florence Danède, C. J. Dias, M. Margarida Cardoso, Natália T. Correia, M. Teresa Viciosa and Madalena Dionísio Source Type: research

Acute toxicity and histopathological effects of naproxen in zebrafish (Danio rerio) early life stages.
Abstract Zebrafish (Danio rerio) embryos and larvae were selected to investigate the potential risk and aquatic toxicity of a widely used pharmaceutical, naproxen. The acute toxicity of naproxen to embryos and larvae was measured, respectively. The histopathology was investigated in the liver of zebrafish larvae after 8-day embryo-larvae exposure to naproxen. The values of 96-h LC50 were 115.2 mg/L for embryos and 147.6 mg/L for larvae, indicating that zebrafish embryos were more sensitive than larvae to naproxen exposure. Large suites of symptoms were induced in zebrafish (D. rerio) early life stages by differen...
Source: Environmental Science and Pollution Research International - June 18, 2016 Category: Environmental Health Authors: Li Q, Wang P, Chen L, Gao H, Wu L Tags: Environ Sci Pollut Res Int Source Type: research

0053 : Naproxen as an alternative to aspirin for platelet inhibition in patients with cardiovascular disease requiring nonsteroidal anti-inflammatory drug?
Conclusion Naproxen has a stable biological antiplatelet effect similar to aspirin. However, after naproxen or ibuprofen, aspirin was unable to inhibit platelet aggregation. These results suggest than NSAIDs could block the action of aspirin on platelets for several days. The author hereby declares no conflict of interest (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - June 16, 2016 Category: Cardiology Source Type: research

Arylhydrazone derivatives of naproxen as new analgesic and anti-inflammatory agents: Design, synthesis and molecular docking studies
Publication date: June 2016 Source:Journal of Molecular Graphics and Modelling, Volume 67 Author(s): Homa Azizian, Zahra Mousavi, Hamidreza Faraji, Mohammad Tajik, Kowsar Bagherzadeh, Peyman Bayat, Abbas Shafiee, Ali Almasirad A series of new arylidenehydrazone derivatives of naproxen were synthesized and evaluated for their analgesic and anti-inflammatory activities. Some of the synthesized analogues showed comparable activities when compared against naproxen for their analgesic and anti-inflammatory properties. 2-(6-methoxy-2-naphthyl)-N′-[(pyridine-4-yl)methylene]propanoic acid hydrazide 4j was found to be t...
Source: Journal of Molecular Graphics and Modelling - June 14, 2016 Category: Molecular Biology Source Type: research

Occurrence, fate and removal efficiencies of pharmaceuticals in wastewater treatment plants (WWTPs) discharging in the coastal environment of Algiers
Publication date: Available online 13 June 2016 Source:Comptes Rendus Chimie Author(s): Amine Elmouatezz Bellah Kermia, Djamila Fouial-Djebbar, Mohamed Trari In the last few decades, the presence of pharmaceutical products in the environment is known under the name of emerging contaminants. These substances can enter the aquatic environment via different sources, as parent compounds, metabolites or a combination of both. In this work, we have investigated the presence of four pharmaceutical active compounds belonging to the group of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), in wastewater, surface water and drink...
Source: Comptes Rendus Chimie - June 14, 2016 Category: Chemistry Source Type: research

Thermal Solvent-Free Method of Loading of Pharmaceutical Cocrystals into the Pores of Silica Particles: A Case of Naproxen/Picolinamide Cocrystal
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.6b05302 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - June 13, 2016 Category: Chemistry Authors: Ewa Skorupska, Agata Jeziorna and Marek J. Potrzebowski Source Type: research

Prediction of fetal ductus arteriosus constriction by systemic and local dermatological formulations of NSAIDs based on PK/PD analysis.
CONCLUSION: These results suggest that risk to the fetus should be carefully considered before administration of NSAIDs (especially systemic formulations, but including dermatological formulations) to women in the third trimester of pregnancy. PMID: 27285464 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - June 12, 2016 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Effects of kinesiotaping versus non-steroidal anti-inflammatory drugs and physical therapy for treatment of pes anserinus tendino-bursitis: A randomized comparative clinical trial.
CONCLUSION: Kinesiotaping is more effective than naproxen plus physical therapy in reduction of pain and swelling in patients with pes anserinus tendino-bursitis. CLINICAL TRIAL REGISTRATION: identifier is NCT01680263. PMID: 27276165 [PubMed - as supplied by publisher] (Source: The Physician and Sportsmedicine Online)
Source: The Physician and Sportsmedicine Online - June 11, 2016 Category: Sports Medicine Tags: Phys Sportsmed Source Type: research

Challenge of the supercritical antisolvent technique SAS to prepare cocrystal-pure powders of naproxen-nicotinamide
Publication date: 1 November 2016 Source:Chemical Engineering Journal, Volume 303 Author(s): C. Neurohr, A. Erriguible, S. Laugier, P. Subra-Paternault Crystallization assisted by supercritical CO2 has been long ago developed for micronization purposes, but its application to fabricate cocrystals is in its infancy. In this work, the cocrystallization of naproxen and nicotinamide was investigated using CO2 as an antisolvent. In the so-called SAS technique (Supercritical AntiSolvent) a solution of the species dissolved in acetone was injected into a continuous flow of CO2. The conditions of temperature and pressure wer...
Source: Chemical Engineering Journal - June 11, 2016 Category: Chemistry Source Type: research

Suppository naproxen reduces incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis: Randomized controlled trial.
CONCLUSION: Single dose of suppository naproxen administered immediately before ERCP reduces the incidence of PEP. PMID: 27275104 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Mansour-Ghanaei F, Joukar F, Taherzadeh Z, Sokhanvar H, Hasandokht T Tags: World J Gastroenterol Source Type: research

Determination of ibuprofen, naproxen and diclofenac in aqueous samples using a multi-template molecularly imprinted polymer as selective adsorbent for solid-phase extraction
This study describes the application of multi-template molecularly imprinted polymer (MIP) as selective sorbent in the solid-phase extraction (SPE) of naproxen, ibuprofen and diclofenac from wastewater and river water. MIP was synthesized at 70°C by employing naproxen, ibuprofen and diclofenac as multi-templates, ethylene glycol dimethacrylate, 2-vinyl pyridine and toluene as cross-linker, functional monomer and porogen, respectively. Wastewater and river water samples (pH 2.5) were percolated through SPE cartridge packed with 50mg of the MIP. The cartridge was washed with 2mL of methanol-water 10:90% (v:v) prior to eluti...
Source: Journal of Pharmaceutical and Biomedical Analysis - June 5, 2016 Category: Drugs & Pharmacology Source Type: research

Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial
Rebamipide is a gastroprotective agent with promising results against gastric damage induced by non-steroidal anti-inflammatory drugs. The present study evaluated if rebamipide protects against naproxen-induce... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 4, 2016 Category: Gastroenterology Authors: Thiago Gagliano-Jucá, Ronilson A. Moreno, Tiago Zaminelli, Mauro Napolitano, Antônio Frederico N. Magalhães, Aloísio Carvalhaes, Miriam S. Trevisan, John L. Wallace and Gilberto De Nucci Source Type: research

Suitability of passive sampling for the monitoring of pharmaceuticals in Finnish surface waters.
Abstract The occurrence of five pharmaceuticals, consisting of four anti-inflammatory and one antiepileptic drug, was studied by passive sampling and grab sampling in northern Lake Päijänne and River Vantaa. The passive sampling was performed by using Chemcatcher® sampler with a SDB-RPS Empore disk as a receiving phase. In Lake Päijänne, the sampling was conducted during summer 2013 at four locations near the discharge point of a wastewater treatment plant and in the years 2013 and 2015 at four locations along River Vantaa. The samples were analyzed by liquid chromatography coupled to tandem mass spectrometry ...
Source: Environmental Science and Pollution Research International - June 3, 2016 Category: Environmental Health Authors: Lindholm-Lehto PC, Ahkola HS, Knuutinen JS, Koistinen J, Lahti K, Vahtera H, Herve SH Tags: Environ Sci Pollut Res Int Source Type: research

(Source: Reactions Weekly)
Source: Reactions Weekly - June 1, 2016 Category: Drugs & Pharmacology Source Type: research

Removal of pharmaceuticals from synthetic wastewater in an aerobic granular sludge membrane bioreactor and determination of the bioreactor microbial diversity.
Abstract Five types of pharmaceuticals and personal care products (PPCPs) substances were selected as pollutants in this study. The effects of the removal of these pollutants and the microbial succession process in a granular sludge membrane bioreactor (GMBR) were investigated. Results showed that wastewater containing PPCPs influenced the performance of granular sludge. The removal of the five PPCPs from the GMBR had different effects. The removal rates of prednisolone, norfloxacin and naproxen reached 98.5, 87.8 and 84 %, respectively. The degradation effect in the GMBR system was relatively lower for sulphameth...
Source: Applied Microbiology and Biotechnology - May 28, 2016 Category: Microbiology Authors: Wang XC, Shen JM, Chen ZL, Zhao X, Xu H Tags: Appl Microbiol Biotechnol Source Type: research

Solar photolysis versus TiO2-mediated solar photocatalysis: a kinetic study of the degradation of naproxen and diclofenac in various water matrices.
This study showed that the solar light intensity and the water matrix appear to be the main factors influencing the overall performance of the solar photolysis and TiO2-mediated solar photocatalysis for degradation of DCF and NPX mixtures. PMID: 27230148 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - May 26, 2016 Category: Environmental Health Authors: Kanakaraju D, Motti CA, Glass BD, Oelgemöller M Tags: Environ Sci Pollut Res Int Source Type: research

Arylhydrazone Derivatives of Naproxen as NewAnalgesic and Anti-Inflammatory Agents: Design, Synthesis and Molecular Docking Studies
Publication date: Available online 24 May 2016 Source:Journal of Molecular Graphics and Modelling Author(s): Homa Azizian, Zahra Mousavi, Hamidreza Faraji, Mohammad Tajik, Kowsar Bagherzadeh, Peyman Bayat, Abbas Shafiee, Ali Almasirad A series of new arylidenehydrazone derivatives of naproxen were synthesized and evaluated for their analgesic and anti-inflammatory activities. Some of the synthesized analogues showed comparable activities when compared against naproxen for their analgesic and anti-inflammatory properties. 2-(6-methoxy-2-naphthyl)-N′-[(pyridine-4-yl)methylene]propanoic acid hydrazide 4j was found...
Source: Journal of Molecular Graphics and Modelling - May 24, 2016 Category: Molecular Biology Source Type: research

Curcumin Blocks Naproxen-induced Gastric Antral Ulcerations through Inhibition of Lipid Peroxidation and Activation of Enzymatic Scavengers in Rats.
Abstract Curcumin is a polyphenol derived from the plant Curcuma longa, which is used for the treatment of diseases associated with oxidative stress and inflammation. The present study was undertaken to determine the protective effect of curcumin against naproxen-induced gastric antral ulcerations in rats. Different doses (10, 50, and 100 mg/kg) of curcumin or vehicle (curcumin, 0 mg/kg) were pretreated for 3 days by oral gavage, and then gastric mucosal lesions were caused by 80 mg/kg naproxen applied for 3 days. Curcumin significantly inhibited naproxen-induced gastric antral ulcer area and lipid peroxidation in ...
Source: Journal of Microbiology and Biotechnology - May 20, 2016 Category: Biotechnology Authors: Kim JH, Jin S, Kwon HJ, Kim BW Tags: J Microbiol Biotechnol Source Type: research

Severe ocular side effects with acetazolamide: case report.
CONCLUSION: This was an iatrogenic case of acute angle closure induced by an anterior displacement of the irido-lenticular complex, secondary to the use of acetazolamide. The treatment of this condition involves suspending the drug responsible and applying topical corticosteroids, hypotensive and cycloplegic eye drops, with the aim of lowering the eye pressure and the degree of myopia due to the re-positioning of the irido-lenticular complex. PMID: 27179669 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)
Source: Archivos de la Sociedad Espanola de Oftalmologia - May 18, 2016 Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

Use of non-steroidal anti-inflammatory drugs correlates with the risk of venous thromboembolism in knee osteoarthritis patients: a UK population-based case-control study
Conclusion. Compared with the remote users of NSAIDs, the risk of VTE increased for current users of diclofenac, ibuprofen, meloxicam, and coxibs, but not for naproxen, in the knee OA population. Clinicians should consider the risk profile for specific NSAIDs when recommending their use. (Source: Rheumatology)
Source: Rheumatology - May 17, 2016 Category: Rheumatology Authors: Lee, T., Lu, N., Felson, D. T., Choi, H. K., Dalal, D. S., Zhang, Y., Dubreuil, M. Tags: Osteoarthritis and Cartilage CLINICAL SCIENCE Source Type: research

Effects of reclaimed water matrix on fate of pharmaceuticals and personal care products in soil.
Abstract Reclaimed water is increasingly used to supplement water resources. However, reclaimed water has a complex matrix, which includes emerging chemical contaminants, that is introduced to the soil when this water is used for irrigation. The effects of microbial activity, dissolved matter, nutrients, and particulate matter in reclaimed water on half-life of 11 pharmaceutical and personal care products (PPCPs) in soil were investigated with 7 treatment waters, namely swine lagoon effluent (either unaltered, sterilized, or filtered and sterilized) and nanopure water (either unaltered or with added nitrogen, phosp...
Source: Chemosphere - May 12, 2016 Category: Chemistry Authors: Dodgen LK, Zheng W Tags: Chemosphere Source Type: research

Preparation and characterization of dual-template molecularly imprinted monolith with metal ion as pivot
Publication date: Available online 10 May 2016 Source:European Polymer Journal Author(s): Jing Zhang, Fang Li, Xian-Hua Wang, Dan Xu, Yan-Ping Huang, Zhao-Sheng Liu In this work, a method for improving imprinting efficiency of dual-templates molecularly imprinted polymer was developed based on strategy of metal ion as pivot. Two templates, naproxen (NAP) and ketoprofen (KET), were simultaneously imprinted using 4-vinylpyridine (4-VP) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linker with Co2+ as pivot. A ternary mixture of dimethyl formamide (DMF)- dimethyl sulfoxide (DMSO)- 1-butyl-3-...
Source: European Polymer Journal - May 11, 2016 Category: Chemistry Source Type: research

Method for quantifying NSAIDs and clofibric acid in aqueous samples, lumpfish (Cyclopterus lumpus) roe, and zebrafish (Danio rerio) eleutheroembryos and evaluation of their bioconcentration in zebrafish eleutheroembryos.
Abstract Pharmaceuticals such as nonsteroidal anti-inflammatory drugs (NSAIDs) and lipid regulators are being repeatedly detected at low concentrations (pg · mL(-1)-ng · mL(-1)) in the environment. A large fraction of these compounds are ionizable. Ionized compounds show different physico-chemical properties and environmental behavior in comparison to their neutral analogs; as a consequence, the quantification methods currently available, based on the neutral molecules, might not be suitable to detect the corresponding ionized compounds. To overcome this problem, we developed a specific analytical method ...
Source: Environmental Science and Pollution Research International - May 11, 2016 Category: Environmental Health Authors: Molina-Fernandez N, Perez-Conde C, Rainieri S, Sanz-Landaluze J Tags: Environ Sci Pollut Res Int Source Type: research

Biofabrication of genipin-crosslinked peptide hydrogels and their use in the controlled delivery of Naproxen.
Abstract The synthesis and optimization of peptide-based hydrogel materials have gained growing interest in the last years, thanks to their properties, that make them appealing for diverse biotechnological applications, with a particular focus in the field of biomedicine. The self-assembling abilities of low molecular weight peptides make them ideal for designing advanced materials using mild reaction conditions. In this work, a biocatalytic approach has been used for the synthesis of an Fmoc-tripeptide that is able to self-assemble in water affording a self-supporting hydrogel. The mechanical properties of this ma...
Source: New Biotechnology - May 7, 2016 Category: Biotechnology Authors: Chronopoulou L, Toumia Y, Cerroni B, Pandolfi D, Paradossi G, Palocci C Tags: N Biotechnol Source Type: research

Introduction of high nitrogen doped graphene as a new cationic carrier in electromembrane extraction
This paper proposes for the first time, the use of high nitrogen doped graphene (HND‐G) as a new cationic carrier for the enhancement of electromembrane extraction (EME) performance. Sensitivity of EME was improved by the modification of supported liquid membrane composition through the addition of HND‐G into 1‐octanol for the extraction of naproxen and sodium diclofenac as model acidic drugs. The comparison between HND‐G‐modified EME and conventional EME showed that HND‐G could increase the overall partition coefficient of acidic drugs in the membrane due to the fact that HND‐G acts as an ion pair reagent an...
Source: Electrophoresis - May 2, 2016 Category: Biochemistry Authors: Atefe Atarodi, Mahmoud Chamsaz, Ali Zeraatkar Moghaddam, Hadi Tabani Tags: Research Article Source Type: research

Antinociceptive Activity of an Ethanol Extract of Justicia spicigera
ABSTRACT The aim of the present study was to evaluate the antinociceptive and sedative activity of an ethanol extract of Justicia spicigera an evergreen used in Mexican traditional medicine for the relief of pain, wounds, fever and inflammation. At 200 mg/kg po, the maximum dose examined, the ethanol extract of J. spicigera (JSE) had analgesic activity in mice in the acetic acid writhing test, the second phase of the formalin test and the tail flick test that was similar in efficacy to the NSAID, naproxen (150 mg/kg po). JSE was inactive in the hot plate test and and the ketamine‐induced sleeping time test; it had...
Source: Drug Development Research - May 1, 2016 Category: Drugs & Pharmacology Authors: Juan Ramón Zapata‐Morales, Angel Josabad Alonso‐Castro, Fabiola Domínguez, Candy Carranza‐Álvarez, Luis Manuel Orozco Castellanos, Rosa María Martínez‐Medina, José Pérez‐Urizar Tags: Research Article Source Type: research

Top 20 Research Studies of 2015 for Primary Care Physicians.
This article, the fifth installment in this annual series, summarizes the 20 POEMs based on original research studies judged to have the greatest clinical relevance for family physicians. Key recommendations include questioning the need for backup throat cultures; avoiding early imaging and not adding cyclobenzaprine or oxycodone to naproxen for patients with acute low back pain; and encouraging patients with chronic or recurrent low back pain to walk. Other studies showed that using a nicotine patch for more than eight weeks has little benefit; that exercise can prevent falls that cause injury in at-risk older women; and ...
Source: American Family Physician - May 1, 2016 Category: Primary Care Authors: Ebell MH, Grad R Tags: Am Fam Physician Source Type: research

Impact of chirality on the photoinduced charge transfer in linked systems containing naproxen enantiomers
Phys. Chem. Chem. Phys., 2016, Advance ArticleDOI: 10.1039/C5CP07305G, PaperE. A. Khramtsova, D. V. Sosnovsky, A. A. Ageeva, E. Nuin, M. L. Marin, P. A. Purtov, S. S. Borisevich, S. L. Khursan, H. D. Roth, M. A. Miranda, V. F. Plyusnin, T. V. LeshinaThe model reaction of photoinduced electron transfer in dyads has been used to compare the reactivity of anti-inflammatory drug, (S)-naproxen and its (R)-isomer.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 21, 2016 Category: Chemistry Authors: E. A. Khramtsova Source Type: research

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults.
CONCLUSIONS: The conclusions of this review were not changed. Combination treatment was effective in the acute treatment of migraine headaches. The effect was greater than for the same dose of either sumatriptan or naproxen alone, but additional benefits over sumatriptan alone were not large. More participants achieved good relief when medication was taken early in the attack, when pain was still mild. Adverse events were more common with the combination and sumatriptan alone than with placebo or naproxen alone. PMID: 27096438 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 20, 2016 Category: Journals (General) Authors: Law S, Derry S, Moore RA Tags: Cochrane Database Syst Rev Source Type: research

Molecules, Vol. 21, Pages 509: Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage
In this study, the behavior of the recently identified sodium naproxen-lactose-tetrahydrate co-crystal and the co-amorphous mixture of sodium, naproxen, and lactose was investigated. The structure of the co-crystal is described using single-crystal X-ray diffraction. The structural analysis revealed a monoclinic lattice, space group P21, with the asymmetric unit containing one molecule of lactose, one of naproxen, sodium, and four water molecules. Upon heating, it was observed that the co-crystal transforms into a co-amorphous system due to the loss of its crystalline bound water. Dehydration and co-amorphization were stud...
Source: Molecules - April 19, 2016 Category: Chemistry Authors: Ioana SovagoWenbo WangDanwen QiuDhara RaijadaJukka RantanenHolger GrohganzThomas RadesAndrew BondKorbinian Löbmann Tags: Article Source Type: research

Drugs for the acute treatment of migraine in children and adolescents.
CONCLUSIONS: Low quality evidence from two small trials shows that ibuprofen appears to improve pain freedom for the acute treatment of children with migraine. We have only limited information on adverse events associated with ibuprofen in the trials included in this review. Triptans as a class are also effective at providing pain freedom in children and adolescents but are associated with higher rates of minor adverse events. Sumatriptan plus naproxen sodium is also effective in treating adolescents with migraine. PMID: 27091010 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 19, 2016 Category: Journals (General) Authors: Richer L, Billinghurst L, Linsdell MA, Russell K, Vandermeer B, Crumley ET, Durec T, Klassen TP, Hartling L Tags: Cochrane Database Syst Rev Source Type: research

Molecules, Vol. 21, Pages 420: Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives
The current study focuses on the synthesis of several hybrid individuals combining a natural oleanolic acid skeleton and synthetic nonsteroidal anti-inflammatory drug moieties (NSAIDs). It studied structural modifications of the oleanolic acid structure by use of the direct reactivity of hydroxyl or hydroxyimino groups at position C-3 of the triterpenoid skeleton with the carboxylic function of anti-inflammatory drugs leading to new perspective compounds with high potential pharmacological activities. Novel ester- and iminoester-type derivatives of oleanolic unit with the different NSAIDs, such as ibuprofen, aspirin, napro...
Source: Molecules - April 12, 2016 Category: Chemistry Authors: Anna PawełczykDorota OlenderKatarzyna Sowa-KasprzakLucjusz Zaprutko Tags: Article Source Type: research

Impact of Chirality on the Photo-Induced Charge Transfer in Linked Systems Containing Naproxen Enantiomers.
Phys. Chem. Chem. Phys., 2016, Accepted ManuscriptDOI: 10.1039/C5CP07305G, PaperEkaterina Andreevna Khramtsova, Denis Viktorovich Sosnovsky, Alexandra Andreevna Ageeva, Edurne Nuin, Maria Luisa Marin, Petr A. Purtov, Sophia S. Borisevich, Sergey L. Khursan, Heinz Roth, Miguel Miranda, Victor F. Plyusnin, Tatyana LeshinaThe model reaction, the photo-induced donor-acceptor interaction in linked systems - dyads, have been used to study the comparative reactivity of a well-known anti-inflammatory drug, (S)-naproxen (NPX) and its (R)-isomer....The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. ...
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 11, 2016 Category: Chemistry Authors: Ekaterina Andreevna Khramtsova Source Type: research

Minimal-change disease and interstitial nephritis secondary to non-steroidal anti-inflammatory drugs (naproxen).
PMID: 27203163 [PubMed - as supplied by publisher] (Source: Therapie)
Source: Therapie - April 11, 2016 Category: Psychiatry & Psychology Authors: Baccouche K, Alaya Z, Azzabi A, Ben Abdelkarim S, Belghali S, El Amri N, Zeglaoui H, Slim R, Bouajina E Tags: Therapie Source Type: research

Fixed Drug Eruption Due to Selective Hypersensitivity to Naproxen with Tolerance to other Propionic Acid NSAIDs.
CONCLUSION: In our patient PT confirmed the diagnosis and allowed us to study the cross-reactivity between NSAIDs of the same group, and confirmed by SBOCT. Cross-reactivity between propionic acid derivatives was studied. This is a case of hypersensitivity to naproxen with good tolerance to other propionic acids NSAIDs (ibuprofen and ketoprofen) and nabumetone, confirmed by PT and SBOCT. Some relavent patents for fixed drug eruption are discussed. PMID: 27041368 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - April 7, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Experimental and theoretical study of molecular interactions between 2-vinyl pyridine and acidic pharmaceuticals used as multi-template molecules in molecularly imprinted polymer
In this study, a multi-template molecularly imprinted polymer (MIP) for ibuprofen, naproxen and diclofenac was synthesized in an oil bath set at 70 °C for 24 hours. 2-vinyl pyridine, ethylene glycol dimethacrylate, toluene and 1,1’-azobis-(cyclohexanecarbonitrile) were used as functional monomer, cross-linker, porogen and radical initiator, respectively. A non-imprinted polymer (NIP) was synthesized using a similar approach with the omission of templates. Monomer-template interactions were examined using Molecular Dynamics and Fourier Transform Infrared Spectroscopy (FTIR). Both molecular dynamics and FT-IR results indi...
Source: Reactive and Functional Polymers - April 3, 2016 Category: Chemistry Source Type: research

Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) like meclofenamate sodium (MS), used to reduce pain, has been associated with an increased risk of cardiovascular disease (CVD). Naproxen (NAP), another NSAID, is not associated with increased risk of CVD. The molecular mechanism(s) by which NSAIDs induce CVD is unknown.We investigated the effects of MS and NAP on protein homeostasis and cardiotoxicity in rat cardiac H9c2 cells and murine neonatal cardiomyocytes.MS, but not NAP, significantly inhibited proteasome activity and reduced cardiac cell viability at pharmacological levels found in humans. (Source: Journal o...
Source: Journal of Molecular and Cellular Cardiology - April 3, 2016 Category: Cytology Authors: Rajeshwary Ghosh, Soyun M. Hwang, Ziyou Cui, Jennifer E. Gilda, Aldrin V. Gomes Source Type: research

Conservative treatment of acute knee osteoarthritis: A review of the Cochrane Library
Conclusions Five main strategies for the conservative treatment of knee osteoarthritis exist that must be used before indicating surgical treatment: medical treatment, physical medicine and rehabilitation, intra-articular injections, acupuncture, and self-management education programs. (Source: Journal of Acute Disease)
Source: Journal of Acute Disease - April 2, 2016 Category: Emergency Medicine Source Type: research

Octadecylamine-Mediated Versatile Coating of CoFe2O4 NPs for the Sustained Release of Anti-Inflammatory Drug Naproxen and in Vivo Target Selectivity
ACS Applied Materials & InterfacesDOI: 10.1021/acsami.6b00408 (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - March 29, 2016 Category: Materials Science Authors: Violetta Georgiadou, George Makris, Dionysia Papagiannopoulou, Georgios Vourlias and Catherine Dendrinou-Samara Source Type: research

Development and validation of an LC-ESI-MS/MS method for the simultaneous quantification of naproxen and sumatriptan in human plasma: application to a pharmacokinetic study.
Abstract A sensitive and fast liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for the simultaneous quantification of naproxen and sumatriptan in human plasma. A simple liquid-liquid extraction procedure, with a mixture of ethyl acetate, methyl tert-butyl ether, and dichloromethane (4:3:3, v/v), was used for the cleanup of plasma. Naratriptan and aceclofenac were employed as internal standards. The analyses were carried out using an ACE C18 column (50 × 4.6 mm i.d.; particle size 5 μm) and a mobile phase consisting of 2 mM aqueous ammo...
Source: Analytical and Bioanalytical Chemistry - March 28, 2016 Category: Chemistry Authors: Brêtas JM, César IC, Brêtas CM, Teixeira LS, Bellorio KB, Mundim IM, Pianetti GA Tags: Anal Bioanal Chem Source Type: research

Course of active inflammatory and fatty lesions in patients with early axial spondyloarthritis treated with infliximab plus naproxen as compared to naproxen alone: Results from the INFAST study
Conclusion. Effective anti‐inflammatory treatment of axSpA was associated with an increase in fatty lesion scores that was independent of the treatment arm. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 25, 2016 Category: Rheumatology Authors: Denis Poddubnyy, Joachim Listing, Joachim Sieper Tags: Brief Report Source Type: research

Hydroxy double salts loaded with bioactive ions: Synthesis, intercalation mechanisms, and functional performance
Publication date: June 2016 Source:Journal of Solid State Chemistry, Volume 238 Author(s): Abdessamad Y. A. Kaassis, Si-Min Xu, Shanyue Guan, David G. Evans, Min Wei, Gareth R. Williams The intercalation of the anions of diclofenac (Dic), naproxen (Nap), and valproic acid (Val) into three hydroxy double salts (HDSs) has been explored in this work. Experiments were performed with [Co1.2Zn3.8(OH)8](NO3)2·2H2O (CoZn-NO3), [Ni2Zn3(OH)8](NO3)2·2H2O (NiZn-NO3) and [Zn5(OH)8](NO3)2·2H2O (Zn-NO3). It proved possible to intercalate diclofenac and naproxen into all three HDSs. In contrast, Val could be intercalated into C...
Source: Journal of Solid State Chemistry - March 22, 2016 Category: Chemistry Source Type: research

Mesoporous silica based MCM-41 as solid-phase extraction sorbent combined with micro-liquid chromatography-quadrupole-mass spectrometry for the analysis of pharmaceuticals in waters.
Abstract This paper reports the first application of the silica based mesoporous material MCM-41 as a sorbent in solid phase extraction, to pre-concentrate pharmaceuticals of very different polarity (atenolol, nadolol, pindolol, timolol, bisoprolol, metoprolol, betaxolol, ketoprofen, naproxen, ibuprofen, diclofenac, tolfenamic acid, flufenamic acid and meclofenamic acid) in surface waters. The analytes were extracted from 100mL water samples at pH 2.0 (containing 10(-3)mol/L of sodium chloride) by passing the solution through a cartridge filled with 100mg of MCM-41. Following elution, the pharmaceuticals were deter...
Source: Talanta - March 20, 2016 Category: Chemistry Authors: Dahane S, Martínez Galera M, Marchionni ME, Socías Viciana MM, Derdour A, Gil García MD Tags: Talanta Source Type: research

Coatings of molecularly imprinted polymers based on polyhedral oligomeric silsesquioxane for open tubular capillary electrochromatography.
Abstract Polyhedral oligomeric silsesquioxane (POSS) was successfully applied, for the first time, to prepare imprinted monolithic coating for capillary electrochromatography. The imprinted monolithic coating was synthesized with a mixture of PSS-(1-Propylmethacrylate)-heptaisobutyl substituted (MA 0702), S-amlodipine (template), methacrylic acid (functional monomer), and 2-methacrylamidopropyl methacrylate (crosslinker), in a porogenic mixture of toluene-isooctane. The influence of synthesis parameters on the imprinting effect and separation performance, including the amount of MA 0702, the ratio of template to mo...
Source: Talanta - March 20, 2016 Category: Chemistry Authors: Zhao QL, Zhou J, Zhang LS, Huang YP, Liu ZS Tags: Talanta Source Type: research

Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis
Publication date: Available online 18 March 2016 Source:The Lancet Author(s): Bruno R da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Jüni, Sven Trelle Background Non-steroidal anti-inflammatory drugs (NSAIDs) are the backbone of osteoarthritis pain management. We aimed to assess the effectiveness of different preparations and doses of NSAIDs on osteoarthritis pain in a network meta-analysis. Methods For this network meta-analysis, we considered randomised trials comparing any of the following interventions: NSAIDs, paracetamol, or placebo, for the treatment of osteoarthritis pain. ...
Source: The Lancet - March 18, 2016 Category: Journals (General) Source Type: research

[Comment] Does paracetamol still have a future in osteoarthritis?
This study looked at the so-called coxibs as well as diclofenac, naproxen, ibuprofen, and paracetamol, which were mainly used as comparators. (Source: LANCET)
Source: LANCET - March 17, 2016 Category: Journals (General) Authors: Nicholas Moore, Francesco Salvo, Mai Duong, Sinem Ezgi Gulmez Tags: Comment Source Type: research

Sonocatalytic removal of naproxen by synthesized zinc oxide nanoparticles on montmorillonite.
Abstract ZnO/MMT nanocomposite as sonocatalyst was prepared by immobilizing synthesized ZnO on the montmorillonite surface. The characteristics of as-prepared nanocomposite were studied by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM) and X-ray diffraction (XRD) techniques. The synthesized samples were used as a catalyst for sonocatalytic degradation of naproxen. ZnO/MMT catalyst in the presence of ultrasound irradiation was more effective compared to pure ZnO nanoparticles and MMT particles in the sonocatalysis of naproxen. The effect of different operational paramet...
Source: Ultrasonics Sonochemistry - March 13, 2016 Category: Chemistry Authors: Karaca M, Kıranşan M, Karaca S, Khataee A, Karimi A Tags: Ultrason Sonochem Source Type: research

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report
Conclusions This is the first reported case, to the best of our knowledge, of the detection of a secondary malignant giant cell tumor of bone based on fever of unknown origin after long-term (40 years) follow-up. After curettage and bone grafting, giant cell tumor of bone may transform to malignancies within a few years or even decades after surgery. Therefore, meticulous follow-up is essential. The fever might be attributable to the tumor releasing inflammatory cytokines. Not only pain and swelling but also continuous pyrexia may suggest the diagnosis of a secondary malignant giant cell tumor of bone. (Source: ...
Source: Journal of Medical Case Reports - March 8, 2016 Category: Journals (General) Source Type: research

A Strategy for Co-former Selection to Design Stable Co-amorphous Formations Based on Physicochemical Properties of Non-steroidal Inflammatory Drugs
Conclusions The results showed a relationship between stable co-amorphous formation and the physicochemical features of the components, which should inform efficient co-former selection to design stable co-amorphous formations. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2016 Category: Drugs & Pharmacology Source Type: research