Medicine RSS Search Engine

Aleve Aleve RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the latest research publications in this category.

Risk of ischaemic stroke associated with non‐steroidal antiinflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischaemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients at high background CV risk.This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - January 22, 2015 Category: Hematology Authors: Patricia García‐Poza, Francisco J. Abajo, Miguel J. Gil, Ana Chacón, Verónica Bryant, Luis A. García‐Rodríguez Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

The Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies
The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles related to acute ...
Source: Headache: The Journal of Head and Face Pain - January 20, 2015 Category: Neurology Authors: Michael J. Marmura, Stephen D. Silberstein, Todd J. Schwedt Tags: American Headache Society Evidence Assessment Source Type: research

Chronic exposure to pollutants in Madín Reservoir (Mexico) alters oxidative stress status and flesh quality in the common carp Cyprinus carpio.
This study aimed to evaluate whether chronic exposure to pollutants in MR alters oxidative stress status and flesh quality in muscle of the common carp Cyprinus carpio. The following biomarkers were evaluated in muscle of carp caught in the general area of discharge from the town of Viejo Madín: hydroperoxide content (HPC), lipid peroxidation (LPX), protein carbonyl content (PCC), and activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Physicochemical and textural properties of muscle were also evaluated. Results show that the metals Al and Fe were accumulated ...
Source: Environmental Science and Pollution Research International - January 14, 2015 Category: Environmental Health Authors: Morachis-Valdez G, Dublán-García O, López-Martínez LX, Galar-Martínez M, Saucedo-Vence K, Gómez-Oliván LM Tags: Environ Sci Pollut Res Int Source Type: research

Optic neuritis in juvenile idiopathic arthritis patient
In conclusion, a low prevalence of ON was observed in our JIA population. The absence of anti-AQP4 antibody and the normal brain MRI do not exclude the possibility of demyelinating disease associated with chronic arthritis. Therefore, rigorous follow up is required. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - January 10, 2015 Category: Rheumatology Source Type: research

Marginally Designed New Profen Analogues Have the Potential to Inhibit Cyclooxygenase Enzymes
The current structure–activity relationship of profens (i.e., 2‐arylpropionic acid derivatives, a class of non‐steroidal anti‐inflammatory drugs) discusses the importance of α‐monomethyl substitution on these compounds, since the activities obtained through their corresponding arylacetic acid derivatives (i.e., α‐demethylated derivatives) or α,α‐dimethyl‐substituted compounds are less than what is observed for the parent profens. Unfortunately, this implies a generalization in structure–activity relationships of profens in such a way that a mono‐(non‐methyl)alkyl group or dialkyl substituent repla...
Source: Archiv der Pharmazie - January 8, 2015 Category: Drugs & Pharmacology Authors: Hayrettin O. Gülcan, Serdar Ünlü, Anatoli Dimoglo, Yasemin Şahin, İlker Esiringu, Tuba Erçetin, Demet Öz, Mustafa F. Şahin Tags: Full Paper Source Type: research

Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis: A Systematic Review and Network Meta-analysis.
CONCLUSION: This method allowed comparison of common treatments of knee OA according to their relative efficacy. Intra-articular treatments were superior to nonsteroidal anti-inflammatory drugs, possibly because of the integrated IA placebo effect. Small but robust differences were observed between active treatments. All treatments except acetaminophen showed clinically significant improvement from baseline pain. This information, along with the safety profiles and relative costs of included treatments, will be helpful for individualized patient care decisions. PRIMARY FUNDING SOURCE: Agency for Healthcare Research and...
Source: Annals of Internal Medicine - January 6, 2015 Category: Internal Medicine Authors: Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE Tags: Ann Intern Med Source Type: research

Primary headache in yemen: prevalence and common medications used.
Conclusion. We concluded that absence of health attention from the Yemeni Community and education from the health system in the country regarding analgesics use and their potential risk led to abuse of such medications and could be a reason beyond high prevalence of headache in Yemen. PMID: 25538854 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - January 3, 2015 Category: Neurology Tags: Neurol Res Int Source Type: research

Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability
Publication date: 30 January 2015 Source:International Journal of Pharmaceutics, Volume 478, Issue 2 Author(s): Benjamin Wuyts , Danny Riethorst , Joachim Brouwers , Jan Tack , Pieter Annaert , Patrick Augustijns The Ussing chambers model is almost exclusively used in the presence of plain aqueous phosphate buffers as solvent system. In an attempt to further elucidate the effect of luminal ingredients and postprandial conditions on intestinal permeability, pooled fasted and fed state human intestinal fluids (FaHIFpool, FeHIFpool) were used. In addition, simulated intestinal fluids of both nutritional states (FaSSIF, FeSS...
Source: International Journal of Pharmaceutics - January 3, 2015 Category: Drugs & Pharmacology Source Type: research

Spontaneous Resolution of Quadrilateral Space Syndrome: A Case Report
ABSTRACTA case of quadrilateral space syndrome is presented, where a large near-circumferential glenoid labrum tear led to a paralabral cyst that dissected into the quadrilateral space and caused a compressive neuropathy of the axillary nerve. This led to a 6-mo history of left shoulder pain, parasthesias, marked weakness to abduction, and marked denervation in both the deltoid and teres minor on electro-diagnostics. This is a presentation of interest as it is the only case report in the literature, to the authors’ knowledge, where spontaneous resolution of entrapment occurred. This normally requires intervention for def...
Source: American Journal of Physical Medicine and Rehabilitation - January 1, 2015 Category: Rehabilitation Tags: Case Reports Source Type: research

The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies.
Abstract The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles ...
Source: Headache - January 1, 2015 Category: Neurology Authors: Marmura MJ, Silberstein SD, Schwedt TJ Tags: Headache Source Type: research

Photochemical properties of gemifloxacin: A laser flash photolysis study
Publication date: Available online 19 December 2014 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): Xu Yulie , Liu Yancheng , Zhao Jianfeng , Li Haixia , Zhang Peng , Wang Wenfeng The photochemical properties of gemifloxacin (GEFX), a fluoroquinolone antibacterial drug that exhibits phototoxicity toward biological substrates, were studied in aqueous solutions by Laser flash photolysis (LFP) and pulse radiolysis. GEFX triplet state (3GEFX∗) absorption spectra showed maximum absorption at 510 nm. 3GEFX∗ was quenched by naproxen (NAP) via energy transfer with a rate constant of 1.2×108 dm3 mol...
Source: Journal of Photochemistry and Photobiology B: Biology - December 25, 2014 Category: Speech Therapy Source Type: research

Optic neuritis in juvenile idiopathic arthritis patient
In conclusion, a low prevalence of ON was observed in our JIA population. The absence of anti-AQP4 antibody and the normal brain MRI do not exclude the possibility of demyelinating disease associated with chronic arthritis. Therefore, rigorous follow up is required. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - December 20, 2014 Category: Rheumatology Source Type: research

Modeling of drug solubility in supercritical carbon dioxide using equation of state based on hole theory with molecular surface charge density
Publication date: December 2014 Source:Chemical Engineering Research and Design, Volume 92, Issue 12 Author(s): Junichi Sakabe , Hirohisa Uchida , Yusuke Shimoyama Equation of state based on hole theory with molecular surface charge density was developed for the modeling of drug solubility in supercritical carbon dioxide. In the hole theory, the density change of supercritical carbon dioxide can be represented by the number of holes in the system. The molecular interaction energy parameter was estimated using the interactions of segments on the molecular surface given by a quantum calculation using conductor-like screeni...
Source: Chemical Engineering Research and Design - December 8, 2014 Category: Chemistry Source Type: research

Pharmacokinetic Comparison Study of a Combination Containing 500 mg of Naproxen and 20 mg of Esomeprazole: A Randomized, Single-Dose, 2-Way Crossover, Open-Label Study in Healthy Korean Men.
This study was performed for the subsequent marketing of a combination drug that contained 500 mg of naproxen and 20 mg of esomeprazole in Korea. We evaluated the comparative bioavailability and tolerability of the test and reference formulations in healthy men. METHODS: A total of 60 healthy men were enrolled in this single-dose, randomized, open-label, 2-period, 2-sequence, crossover study. During each period, men received a combination of 500 mg of naproxen and 20 mg of esomeprazole for test or reference, and between each period, there was a 1-week washout period. Blood samples were obtained 21 times throughout each...
Source: Clinical Therapeutics - December 4, 2014 Category: Drugs & Pharmacology Authors: Choi HG, Jeon JY, Kwak SS, Kim H, Jin C, Im YJ, Kim EY, Wang HM, Kim Y, Lee SY, Kim MG Tags: Clin Ther Source Type: research

Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice
Conclusions: These data demonstrate that ATB-346 can be efficacious in a TBI animal model by reducing the secondary inflammation and tissue injury. Therefore, ATB-346 could represent an interesting approach for the management of secondary damage following CNS diseases, counteracting behavioral changes and inflammatory process. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 4, 2014 Category: Neurology Authors: Michela CampoloEmanuela EspositoAkbar AhmadRosanna Di PaolaIrene PaternitiMarika CordaroGiuseppe BruschettaJohn WallaceSalvatore Cuzzocrea Source Type: research

Efficacy of etoricoxib, celecoxib, lumiracoxib, non-selective NSAIDs, and acetaminophen in osteoarthritis: a mixed treatment comparison.
CONCLUSION: The current study estimated the efficacy of acetaminophen, nsNSAIDs, and COX-2 selective NSAIDs in OA and found that etoricoxib 30 mg is likely to result in the greatest improvements in pain and physical function. Differences in PGADS between interventions were smaller. PMID: 22582102 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - December 2, 2014 Category: Rheumatology Tags: Open Rheumatol J Source Type: research

Comparison of the effect of Naproxen, Etodolac and Diclofenac on postoperative sequelsfollowing third molar surgery: a randomised, double-blind, crossover study.
CONCLUSION: NSAIDs (Diclofenac, Naproxen and Etodolac) are somehow similarly effective for controlling pain and trismus following extraction of mandibular third molars but Diclofenac potassium surpasses others in reduction of swelling. PMID: 24316711 [PubMed - in process] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - December 2, 2014 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research

Undetected Ultracet™ dependence in an adolescent with nonmalignant back pain.
This report discusses an 18-year-old woman with idiopathic scoliosis and clinical depression secondary to undertreated refractory chronic back pain who underwent surgery to correct pseudoarthrosis after a prior spinal instrumentation operation. This intervention in conjunction with a course of patient-controlled analgesia, hydromorphone, and outpatient tramadol, naproxen, methadone, and gabapentin was successful in addressing her long-standing lumbar pain. The patient, however, continued to complain to her pain management team of postsurgical discomfort and insisted on being prescribed Ultracet™ (acetaminophen-tramadol) ...
Source: Journal of Opioid Management - December 2, 2014 Category: Addiction Tags: J Opioid Manag Source Type: research

Functional Adrenal Insufficiency Complicating an Overdose of Naproxen and Ibuprofen
(Source: Clinical Pediatrics)
Source: Clinical Pediatrics - December 2, 2014 Category: Pediatrics Authors: Akingbola, O. A., Singh, D., Kleinman, J. A., Frieberg, E. M. Tags: Brief Reports Source Type: research

Competitive adsorption of selected non-steroidal anti-inflammatory drugs on activated biochars: Experimental and molecular modeling study
Publication date: 15 March 2015 Source:Chemical Engineering Journal, Volume 264 Author(s): Chanil Jung , Linkel K. Boateng , Joseph R.V. Flora , Jeill Oh , Marcus C. Braswell , Ahjeong Son , Yeomin Yoon The adsorption of targeted non-steroidal anti-inflammatory drugs: diclofenac (DCF), naproxen (NPX), and ibuprofen (IBP) by two types of activated biochar (N-/O-biochar) was studied in single- and multi-solute adsorption experiments in conjunction with molecular modeling subsequently interpreting the binding energy. The carbonaceous structure of the biochars was elucidated via nuclear magnetic resonance and the intensity o...
Source: Chemical Engineering Journal - December 1, 2014 Category: Chemistry Source Type: research

Screening of non‐steroidal anti‐inflammatory drugs for inhibitory effects on the activities of six UDP‐glucuronosyltransferases (UGT1A1, 1A3, 1A4, 1A6, 1A9, and 2B7) using LC‐MS/MS
This article is protected by copyright. All rights reserved. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - December 1, 2014 Category: Drugs & Pharmacology Authors: Jeongmin Joo, Yang‐Weon Kim, Zhexue Wu, Jung‐Hoon Shin, Boram Lee, Jong Cheol Shon, Eun Young Lee, Nguyen Minh Phuc, Kwang‐Hyeon Liu Tags: Short Communication Source Type: research

Pharmacological modulation of hand pain in osteoarthritis: A double‐blinded placebo‐controlled functional magnetic resonance imaging study using naproxen
Conclusion This study demonstrates the sensitivity of fMRI to detect the mechanisms underlying treatments of known efficacy. These data illustrate the enticing potential of fMRI as an adjunct to self‐report for detecting early signals of efficacy for novel therapies, both pharmacological and non‐pharmacological, in small numbers of individuals suffering persistent pain. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 1, 2014 Category: Rheumatology Authors: Duncan Sanders, Kristina Krause, Jonathan O'Muircheartaigh, Michael A. Thacker, John P. Huggins, Bill Vennart, Nathalie J. Massat, Ernest Choy, Steven C.R. Williams, Matthew A. Howard Tags: Full Length Source Type: research

Double-blind, placebo-controlled, crossover study of early-intervention with sumatriptan 85/naproxen sodium 500 in (truly) episodic migraine: what's neck pain got to do with it?
CONCLUSION: Our study results support a fundamental re-evaluation of the role of neck pain in migraine. PMID: 24685971 [PubMed - indexed for MEDLINE] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - November 28, 2014 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial
Conclusions Paracetamol/CR oxycodone and paracetamol/naproxen are equally effective in treatment of acute postoperative pain at home after ambulatory surgery with comparable patient satisfaction level. We suggest paracetamol/CR oxycodone to be a valuable alternative for the current paracetamol/naproxen gold standard, particularly in patients with a contraindication for nonsteroidal anti-inflammatory drugs. ClinicalTrials.gov identifier: NCT02152592. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 28, 2014 Category: Drugs & Pharmacology Source Type: research

Comparison of the postoperative analgesic effects of naproxen sodium and naproxen sodium-codeine phosphate for arthroscopic meniscus surgery
Conclusions The combination of naproxen sodium-codeine phosphate provided more effective analgesia than naproxen sodium and did not increase side effects. (Source: Brazilian Journal of Anesthesiology)
Source: Brazilian Journal of Anesthesiology - November 28, 2014 Category: Anesthesiology Source Type: research

Aspirin-dependent cyclooxygenase acetylation [Medical Sciences]
The cardiovascular safety of nonsteroidal antiinflammatory drugs (NSAIDs) may be influenced by interactions with antiplatelet doses of aspirin. We sought to quantitate precisely the propensity of commonly consumed NSAIDs—ibuprofen, naproxen, and celecoxib—to cause a drug–drug interaction with aspirin in vivo by measuring the target engagement of aspirin directly by MS.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 25, 2014 Category: Science Authors: Li, X., Fries, S., Li, R., Lawson, J. A., Propert, K. J., Diamond, S. L., Blair, I. A., FitzGerald, G. A., Grosser, T. Tags: Biological Sciences Source Type: research

Hydrogen sulphide protects against NSAID‐enteropathy through modulation of bile and the microbiota
Conclusions and ImplicationsHydrogen sulphide protects against NSAID‐enteropathy in rats, in part reducing the cytotoxicity of bile and preventing NSAID‐induced dysbiosis. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: Rory W Blackler, Jean‐Paul Motta, Anna Manko, Matthew Workentine, Premysl Bercik, Michael G Surette, John L Wallace Tags: RESEARCH PAPER Source Type: research

Atrial fibrillation in patients undergoing surgical revascularization: an update on pharmacologic prophylaxis.
Authors: Rostagno C Abstract Atrial fibrillation occurs in 20-50% of patients after surgical revascularization (40% have more than 1 episode), with a peak between 2nd and 3rd postoperative days. Postoperative atrial fibrillation (POAF) has been associated with an increase in adverse events, length of hospital stay and, therefore, cost of care, and late mortality. A higher risk profile in patients who develop POAF may contribute to the higher late mortality rate. The pathogenesis of PAOF is multi factorial: transient ischemia during surgical procedure, neurohormonal activation, electrolyte imbalance, fluid overload ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Characterization of cefalexin degradation capabilities of two Pseudomonas strains isolated from activated sludge
Publication date: 23 January 2015 Source:Journal of Hazardous Materials, Volume 282 Author(s): Bokun Lin , Jinling Lyu , Xian-jin Lyu , Han-qing Yu , Zhong Hu , James C.W. Lam , Paul K.S. Lam Pharmaceuticals have recently been regarded as contaminants of emerging concern. To date, there is limited knowledge about antibiotic-degrading microorganisms in conventional activated sludge treatment systems and their characteristics toward antibiotic degradation especially in the presence of a pharmaceutical mixture. As such, antibiotic-degrading microorganisms were investigated and isolated from the activated sludge, and their d...
Source: Journal of Hazardous Materials - November 21, 2014 Category: Environmental Health Source Type: research

Molecular Dynamics Simulations of Complex Mixtures Aimed at the Preparation of Naproxen-Imprinted Xerogels
Journal of Chemical Information and ModelingDOI: 10.1021/ci5004575 (Source: Journal of Chemical Information and Modeling)
Source: Journal of Chemical Information and Modeling - November 19, 2014 Category: Chemistry Authors: Riccardo Concu, Martin Perez, M. Natália D. S. Cordeiro and Manuel Azenha Source Type: research

Assessment of organotins against the linoleic acid, glutathione and CT-DNA
Publication date: 1 November 2014 Source:Inorganica Chimica Acta, Volume 423, Part B Author(s): C.N. Banti , E.I. Gkaniatsou , N. Kourkoumelis , M.J. Manos , A.J. Tasiopoulos , T. Bakas , S.K. Hadjikakou The already known di-n-butyltin(IV) complex of the chiral anti-inflammatory drug naproxen (Hnapr) of formula [(n-Bu-)2Sn(nap)2] (1), was re-synthesized here with an alternative method and it was used for the assessment of organotins towards the linoleic acid which is located in the cell membrane, the intracellular glutathione and the nuclear CT-DNA. The compound was characterized by melting point (m.p.) 119Sn Mössbauer ...
Source: Inorganica Chimica Acta - November 17, 2014 Category: Chemistry Source Type: research

Electrochemically controlled in-tube solid phase microextraction of naproxen from urine samples using an experimental design
Analyst, 2015, Advance ArticleDOI: 10.1039/C4AN01664E, PaperSeyyed Hamid Ahmadi, Ahmad Manbohi, Kourosh Tabar HeydarElectrochemically controlled in-tube SPME approach, which increased the sensitivity and decreased the extraction time, was reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - November 15, 2014 Category: Chemistry Authors: Seyyed Hamid Ahmadi Source Type: research

Naproxen Attenuates Sensitization of Depressive-Like Behavior and Fever during Maternal Separation
Publication date: Available online 14 November 2014 Source:Physiology & Behavior Author(s): Michael B. Hennessy , Nathan P. Stafford , Brittany Yusko-Osborne , Patricia A. Schiml , Evan D. Xanthos , Terrence Deak Early life stress can increase susceptibility for later development of depressive illness though a process thought to involve inflammatory mediators. Isolated guinea pig pups exhibit a passive, depressive-like behavioral response and fever that appear mediated by proinflammatory activity, and which sensitize with repeated separations. Treatment with an anti-inflammatory can attenuate the behavioral respo...
Source: Physiology and Behavior - November 14, 2014 Category: Physiology Source Type: research

Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
Publication date: 5 December 2014 Source:Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 463 Author(s): R. Rojas , A.F. Jimenez-Kairuz , R.H. Manzo , C.E. Giacomelli This work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceed...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - November 14, 2014 Category: Chemistry Source Type: research

Optic neuritis in juvenile idiopathic arthritis patient
In conclusion, a low prevalence of ON was observed in our JIA population. The absence of anti-AQP4 antibody and the normal brain MRI do not exclude the possibility of demyelinating disease associated with chronic arthritis. Therefore, rigorous follow up is required. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 7, 2014 Category: Rheumatology Source Type: research

Upgrading the performances of ultrafiltration membrane system coupled with activated sludge reactor by addition of biofilm supports for the treatment of hospital effluents
Publication date: 15 February 2015 Source:Chemical Engineering Journal, Volume 262 Author(s): Alrhmoun Mousaab , Carrion Claire , Casellas Magali , Dagot Christophe The biological treatment of an hospital effluent has been monitored during 150days in an activated sludge system followed by an ultrafiltration membrane (BBR-UF). After 75days, support media was added into the bioreactor to develop a biofilm and to compare process performances of the two reactor configurations: activated sludge (AS-UF) or biofilm biological reactor (BBR-UF). The removal efficiencies of (chemical oxygen demand) COD, (total suspended solids) TS...
Source: Chemical Engineering Journal - November 3, 2014 Category: Chemistry Source Type: research

Does ongoing general practitioner care in elderly patients help reduce the risk of unplanned hospitalization related to Beers potentially inappropriate medications?
ConclusionsIncreased requirement for ongoing GP contact in less healthy elderly people appears to help minimize their risk of unplanned hospitalization due to PIM‐related harm. GPs should continue to avoid Beers medications in older patients where possible, given their greater predisposition to medication exposure (including PIM) and adverse drug events. Nevertheless, close monitoring of elderly patients who need to use PIM should prove beneficial. Geriatr Gerontol Int 2014; ●●: ●●–●●. (Source: Geriatrics and Gerontology International)
Source: Geriatrics and Gerontology International - November 3, 2014 Category: Geriatrics Authors: Sylvie D Price, C D'Arcy J Holman, Frank M Sanfilippo, Jon D Emery Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Epitheloid Hemangioma Treated With Naproxen Sodium
We present a case of EH of the scrotum in a 14-year-old male patient that regressed after treatment with naproxen sodium. To the best of our knowledge, this represents the first reported case of scrotal EH regression following treatment with naproxen sodium.Level of Evidence: V (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - November 1, 2014 Category: Surgery Tags: Original Articles Source Type: research

Electrochemically controlled in-tube solid phase microextraction of naproxen from urine samples using experimental design
Analyst, 2014, Accepted ManuscriptDOI: 10.1039/C4AN01664E, PaperS. H. Ahmadi, Ahmad Manbohi, K. Heydar TabarA new in-tube solid phase microextraction approach named electrochemically controlled in-tube solid phase microextraction (EC in-tube SPME) has been reported. In this approach, which electrochemistry and in-tube SPME were combined,...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 29, 2014 Category: Chemistry Authors: S. H. Ahmadi Source Type: research

Does Nonsurgical Treatment Improve Longitudinal Outcomes of Lateral Epicondylitis Over No Treatment? A Meta-analysis.
CONCLUSIONS: Pooled data from RCTs indicate a lack of intermediate- to long-term clinical benefit after nonsurgical treatment of lateral epicondylitis compared with observation only or placebo. LEVEL OF EVIDENCE: Level II, therapeutic study. PMID: 25352261 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - October 29, 2014 Category: Orthopaedics Authors: Sayegh ET, Strauch RJ Tags: Clin Orthop Relat Res Source Type: research

Occurrence of selected pharmaceuticals in the principal sewage treatment plants in Rome (Italy) and in the receiving surface waters.
Abstract This paper provides data on the occurrence of selected human pharmaceuticals (carbamazepine, clofibric acid, diclofenac, fenofibrate, fenoprofen, gemfibrozil, ibuprofen, ketoprofen, and naproxen) including steroid hormones (17β-estradiol, 17α-ethinylestradiol, and estrone) in influents/effluents to/from the four principal wastewater treatment plants (WWTPs) serving the city of Rome (Italy), in two different sampling campaigns. Target compounds were also analyzed in the receiving River Tiber and River Aniene. Analytical determination was carried out by LC-MS/MS after sample cleanup and concentration by of...
Source: Environmental Science and Pollution Research International - October 29, 2014 Category: Environmental Health Authors: Patrolecco L, Capri S, Ademollo N Tags: Environ Sci Pollut Res Int Source Type: research

Cardiovascular Risk with Non-steroidal Anti-inflammatory Drugs: Clinical Implications
Abstract In February 2014, the US Food and Drug Administration (FDA) convened an advisory committee meeting to discuss the accumulated data relating to the cardiovascular risk of non-steroidal anti-inflammatory drugs (NSAIDs) and the potential implications on the class prescription labeling. The committee recommended, though not unanimously, that (1) the current data does not support the conclusion that naproxen has a lower risk of thrombotic events than other NSAIDs; (2) there is no latency period for the risk of cardiovascular thrombotic events; (3) there are some patient populations at increased risk for event...
Source: Drug Safety - October 23, 2014 Category: Drugs & Pharmacology Source Type: research

Prophylaxis for acute gout flares after initiation of urate-lowering therapy
This review summarizes evidence relating to prophylaxis for gout flares after the initiation of urate-lowering therapy (ULT). We searched MEDLINE via PubMed for articles published in English from 1963 to 2013 using MEsH terms covering all aspects of prophylaxis for flares. Dispersion of monosodium urate crystals during the initial phase of deposit dissolution with ULT exposes the patient to an increased rate of acute flares that could contribute to poor treatment adherence. Slow titration of ULT might decrease the risk of flares. According to the most recent international recommendation, the two first-line options for prop...
Source: Rheumatology - October 19, 2014 Category: Rheumatology Authors: Latourte, A., Bardin, T., Richette, P. Tags: Crystal Arthritis REVIEWS Source Type: research

Improvement of catalytic activity of lipase in the presence of calix[4]arene valeric acid or hydrazine derivative.
Abstract Sol-gel encapsulation is a simple but powerful method to enhance the enantioselectivity of lipase-catalyzed transformations in an isooctane/aqueous buffer solution. Candida rugosa lipase was encapsulated according to a sol-gel procedure in the presence and absence of calix[4]arene hydrazine or carboxylic acid derivatives with Fe3O4 magnetic nanoparticles as an additive. The activity of the encapsulated lipases was evaluated for the enantioselective hydrolysis of racemic Naproxen methyl ester and the hydrolysis of p-Nitrophenylpalmitate. The results indicate that the encapsulated lipase without calix[4]aren...
Source: Bioprocess and Biosystems Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Akoz E, Sayin S, Kaplan S, Yilmaz M Tags: Bioprocess Biosyst Eng Source Type: research

Breastfeeding and migraine drugs
Conclusions According to our review, the majority of the revised AMDs were assessed to be compatible with breastfeeding. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 16, 2014 Category: Drugs & Pharmacology Source Type: research

Development of a solid self-microemulsifying drug delivery system (SMEDDS) for solubility enhancement of naproxen
Drug Development and Industrial Pharmacy, Ahead of Print. (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - October 13, 2014 Category: Drugs & Pharmacology Tags: article Source Type: research

A quality by design (QbD) case study on enteric-coated pellets: Screening of critical variables and establishment of design space at laboratory scale
Publication date: Available online 28 August 2014 Source:Asian Journal of Pharmaceutical Sciences Author(s): Shuling Kan , Jing Lu , Jianping Liu , Junlin Wang , Yi Zhao The study aims to prepare naproxen enteric-coated pellets (NAP-ECPs) by fluid-bed coating using QbD principle. Risk assessment was firstly performed by using failure mode and effect analysis (FMEA) methodology. A Plackett–Burman design was then used for assessment of the most important variables affecting enteric-coated pellets characteristics. A Box–Behnken design was subsequently used for investigating the main, interactive, and quadratic effects o...
Source: Asian Journal of Pharmaceutical Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research

Hydrogen Sulfide Protects Against NSAID‐Enteropathy Through Modulation of Bile and the Microbiota
Conclusions and implicationsHydrogen sulfide protects against NSAID‐enteropathy in rats, in part reducing the cytotoxicity of bile and preventing NSAID‐induced dysbiosis. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - October 8, 2014 Category: Drugs & Pharmacology Authors: Rory W Blackler, Jean‐Paul Motta, Anna Manko, Matthew Workentine, Premysl Bercik, Michael G Surette, John L Wallace Tags: Research Paper Source Type: research

Migraine-Related Healthcare Resource Use and Costs for Subjects Prescribed Fixed-Dose Combination Sumatriptan/Naproxen Sodium vs. Single-Entity Oral Triptans in a Managed Care Population in the USA
Conclusion Study results suggest similar healthcare resource use patterns and associated costs when comparing S/NS and SOT across a triptan-naïve and triptan-experienced population. While the current study focuses on direct medical costs, future studies should extend beyond such a perspective to explore functional status, productivity, and health-related quality of life and satisfaction, attributes not captured in administrative claims data, but nonetheless important treatment goals. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - October 7, 2014 Category: Health Management Source Type: research

Naproxen Effects on Brain Response to Painful Pressure Stimulation in Patients with Knee Osteoarthritis: A Double-blind, Randomized, Placebo-controlled, Single-dose Study.
CONCLUSION: Naproxen effectively reduces pain-related brain responses involving different regions and the attenuation is related to subjective pain changes. Our current work yields further support to the utility of fMRI to objectify the acute analgesic effects of a single naproxen dose in patients affected by knee OA. The trial was registered at the EuropeanClinicalTrials Database, "EudraCT Number 2008-004501-33". PMID: 25274897 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2014 Category: Rheumatology Authors: Giménez M, Pujol J, Ali Z, López-Solà M, Contreras-Rodríguez O, Deus J, Ortiz H, Soriano-Mas C, Llorente-Onaindia J, Monfort J Tags: J Rheumatol Source Type: research