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Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study
Conclusions Treatment for 1 to 3 years with naproxen or celecoxib did not protect against cognitive decline in older adults with a family history of AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 2, 2015 Category: Geriatrics Source Type: research

Sensing of enantiomeric excess in chiral carboxylic acids.
Abstract Cinchona alkaloids (quinine, quinidine, cinchonine, cinchonidine) alkylated at N(1) with chloromethyl anthracene can serve as fluorescent sensors for chiral carboxylic acids. These cinchona ammonium salts are shown to bind chiral carboxylic acids while displaying an increase in fluorescence intensity that can be utilized in determination of enantiomeric excess (ee). Sensor arrays composed of four cinchona ammonium salts are used for quantitative analysis of ee in several non-steroidal anti-inflammatory drugs (NSAIDs), such as enantiomers of ibuprofen, ketoprofen, and naproxen. PMID: 25720499 [PubMed - ...
Source: Chemical Communications - February 27, 2015 Category: Chemistry Authors: Akdeniz A, Mosca L, Minami T, Anzenbacher P Tags: Chem Commun (Camb) Source Type: research

Cocrystallization induced by compressed CO2 as antisolvent: Simulation of a batch process for the estimation of nucleation and growth parameters
Publication date: March 2015 Source:The Journal of Supercritical Fluids, Volume 98 Author(s): A. Erriguible , C. Neurohr , A.-L. Revelli , S. Laugier , G. Fevotte , P. Subra-Paternault A mathematical model describing the GAS antisolvent process applied to cocrystal formation has been developed with the aim of estimating nucleation and growth parameters that are critical issues in crystallization in general. The estimates are obtained by fitting the particle sizes distribution predicted by the model to experimental data. The investigated system was naproxen+nicotinamide that assembled as cocrystals when recrystallized by ...
Source: The Journal of Supercritical Fluids - February 27, 2015 Category: Chemistry Source Type: research

Solubility of naproxen in 2-propanol+water mixtures at various temperatures
Publication date: June 2015 Source:Journal of Molecular Liquids, Volume 206 Author(s): Mahdis Mohammadzade , Mohammad Barzegar-Jalali , Abolghasem Jouyban The experimental solubility of naproxen in 2-propanol+water mixtures at different temperatures (298.2, 303.2, 308.2 and 313.2K) was reported. The solubility was correlated and/or predicted using three numerical methods; i.e., the combined van't Hoff equation and Jouyban–Acree model (method I), the extended version of the Jouyban–Acree model with Abraham parameters (method II), and the minimum number of data points (N=10) were used to train the combined model. The a...
Source: Journal of Molecular Liquids - February 26, 2015 Category: Molecular Biology Source Type: research

Sustained‐release of naproxen sodium from electrospun‐aligned PLLA–PCL scaffolds
Abstract Spontaneous tendon healing may result in reduced tissue functionality. In view of this, tissue engineering (TE) emerges as a promising approach in promoting proper tendon regeneration. However, unfavourable post‐surgical adhesion formations restrict adequate tendon healing through the TE approach. Naproxen sodium (NPS), a non‐steroidal anti‐inflammatory drug (NSAID), has been demonstrated to prevent adhesions by inhibiting the inflammatory response. Therefore, in this study, various factors, such as polymer composition, i.e. different poly‐l‐lactic acid (PLLA):polycaprolactone (PCL) ratios, and percentag...
Source: Journal of Tissue Engineering and Regenerative Medicine - February 25, 2015 Category: Molecular Biology Authors: Yuan Siang Lui, Mark P. Lewis, Say Chye Joachim Loo Tags: Research Article Source Type: research

Exposure to non-steroid anti-inflammatory drugs (NSAIDs) and suppressing hydrogen sulfide synthesis leads to altered structure and impaired function of the oesophagus and oesophagogastric junction
Conclusions Inhibition of endogenous H2S synthesis provides a novel experimental model that can be useful in preclinical studies NSAID-related non-reflux oesophagitis. H2S contributes significantly to mucosal defence in the oesophagus. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 25, 2015 Category: Drugs & Pharmacology Source Type: research

Pharmacologic Modulation of Hand Pain in Osteoarthritis: A Double‐Blind Placebo‐Controlled Functional Magnetic Resonance Imaging Study Using Naproxen
ConclusionThis study demonstrates the sensitivity of fMRI to detect the mechanisms underlying treatments of known efficacy. The data illustrate the enticing potential of fMRI as an adjunct to self‐report for detecting early signals of efficacy of novel therapies, both pharmacologic and nonpharmacologic, in small numbers of individuals with persistent pain. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 25, 2015 Category: Rheumatology Authors: Duncan Sanders, Kristina Krause, Jonathan O'Muircheartaigh, Michael A. Thacker, John P. Huggins, William Vennart, Nathalie J. Massat, Ernest Choy, Steven C. R. Williams, Matthew A. Howard Tags: Osteoarthritis Source Type: research

Risk of ischemic stroke associated with non‐steroidal anti‐inflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients with a high background CV risk. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - February 24, 2015 Category: Hematology Authors: P. García‐Poza, F. J. Abajo, M. J. Gil, A. Chacón, V. Bryant, L. A. García‐Rodríguez Tags: Original Article Source Type: research

Evaluation of the diuretic activity in two Mexican medicinal species: Selaginella nothohybrida and Selaginella lepidophylla and its effects with ciclooxigenases inhibitors
Conclusions Selaginella nothohybrida presents a moderate diuretic effect, which appears to be in partly mediated by the presence of biflavonoids and trehalose. Renal prostaglandins may be involved in the mechanism of diuresis. The present results provide a quantitative basis explaining the traditional folk medicine use of Selaginella nothohybrida as a diuretic agent by Mexican population. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 21, 2015 Category: Drugs & Pharmacology Source Type: research

The nitric oxide donor cis-[Ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice – Involvement of the soluble guanylate cyclase/KATP pathway
Publication date: Available online 10 February 2015 Source:Nitric Oxide Author(s): Ana Paula M. Santana , Bruno M. Tavares , Larisse T. Lucetti , Florêncio S. Gouveia Jr. , Ronaldo A. Ribeiro , Pedro M.G. Soares , Eduardo H.S. Sousa , Luiz G.F. Lopes , Jand-Venes R. Medeiros , Marcellus H.L.P. Souza Here, we have evaluated the protective effect of the NO donor cis-[Ru(bpy)2(SO3)NO](PF6) (FOR0810) in experimental models of gastric damage induced by naproxen or ethanol in mice, and the involvement of soluble guanylate cyclase (sGC) and ATP-sensitive K+ channels (KATP) in these events. Swiss mice were pre-treated with sali...
Source: Nitric Oxide - February 16, 2015 Category: Chemistry Source Type: research

Removal of acetaminophen and naproxen by combined coagulation and adsorption using biochar: influence of combined sewer overflow components.
Abstract The combined coagulation and adsorption of targeted acetaminophen and naproxen using activated biochar and aluminum sulfate were studied under various synthetic "combined sewer overflow" (CSO) conditions. The biochar demonstrated better adsorption performance for both acetaminophen and naproxen (removal, 94.1 and 97.7 %, respectively) than that of commercially available powdered activated carbon (removal, 81.6 and 94.1 %, respectively) due to superior carbonaceous structure and surface properties examined by nuclear magnetic resonance analysis. The adsorption of naproxen was more favorable, occupying act...
Source: Environmental Science and Pollution Research International - February 15, 2015 Category: Environmental Health Authors: Jung C, Oh J, Yoon Y Tags: Environ Sci Pollut Res Int Source Type: research

The nitric oxide donor cis-[ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice- involvement of the soluble guanylate cyclase /KATP pathway
Publication date: Available online 10 February 2015 Source:Nitric Oxide Author(s): Ana Paula M. Santana , Bruno M. Tavares , Larisse T. Lucetti , Florêncio S. Gouveia , Ronaldo A. Ribeiro , Pedro M.G. Soares , Eduardo H.S. Sousa , Luiz G.F. Lopes , Jand-Venes R. Medeiros , Marcellus H.L.P. Souza Here, we have evaluated the protective effect of the NO donor cis-[Ru(bpy)2(SO3)NO](PF6) (FOR0810) in experimental models of gastric damage induced by naproxen or ethanol in mice, and the involvement of soluble guanylate cyclase (sGC) and ATP-sensitive K+ channels (KATP) in these events. Swiss mice were pre-treated with saline, ...
Source: Nitric Oxide - February 11, 2015 Category: Chemistry Source Type: research

Non-Steroidal Anti-Inflammatory Drugs as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Treatment Effect
Conclusion Current preliminary evidence suggests no beneficial effect of NSAIDs on cognition or overall AD severity. Thus, although more research is needed in the field, the evidence available does not support the use of NSAIDs for AD treatment. (Source: Drugs and Aging)
Source: Drugs and Aging - February 3, 2015 Category: Geriatrics Source Type: research

The Value of Pharmacogenetic Testing—Reply
In Reply We thank Dr Pocinki for sharing his experience with pharmacogenetic testing over the past year. He notes that “with the exception of specific warfarin testing,” pharmacogenetic testing in his patient population has improved clinical decision making and patient outcomes. He cites his experience treating a young woman with chronic pain and “NSAID [nonsteroidal anti-inflammatory drug] intolerance” in whom pharmacogenetic testing showed to be a poor metabolizer of almost all NSAIDs, but suggested she could be treated with naproxen, which is metabolized by a different pathway. Dr Pocinki concludes that “waiti...
Source: JAMA Internal Medicine - February 1, 2015 Category: Internal Medicine Source Type: research

Removal of carbamazepine and naproxen by immobilized Phanerochaete chrysosporium under non-sterile condition.
This study explored the utilization of a white-rot fungus (WRF), Phanerochaete chrysosporium, immobilized in wood chips, to remove carbamazepine and naproxen under non-sterile condition. The removal efficiencies for both pharmaceutically active compounds (PhACs) in artificially contaminated water were improved by 4% for naproxen and 30% for carbamazepine in seven days, compared to without wood chips. Although adsorption was crucial at the early stage, bioremoval was found to be the main removal mechanism for both PhACs. The extracellular enzymes played important roles in the naproxen removal, while the intracellular enzyme...
Source: New Biotechnology - January 27, 2015 Category: Biotechnology Authors: Li X, Toledo RA, Wang S, Shim H Tags: N Biotechnol Source Type: research

Risk of ischaemic stroke associated with non-steroidal antiinflammatory drugs and paracetamol: a population-based case-control study.
CONCLUSIONS: Diclofenac and aceclofenac increase the risk of ischaemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients at high background CV risk. This article is protected by copyright. All rights reserved. PMID: 25611553 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 22, 2015 Category: Hematology Authors: García-Poza P, de Abajo FJ, Gil MJ, Chacón A, Bryant V, García-Rodríguez LA Tags: J Thromb Haemost Source Type: research

Risk of ischaemic stroke associated with non‐steroidal antiinflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischaemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients at high background CV risk.This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - January 22, 2015 Category: Hematology Authors: Patricia García‐Poza, Francisco J. Abajo, Miguel J. Gil, Ana Chacón, Verónica Bryant, Luis A. García‐Rodríguez Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

The Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies
The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles related to acute ...
Source: Headache: The Journal of Head and Face Pain - January 20, 2015 Category: Neurology Authors: Michael J. Marmura, Stephen D. Silberstein, Todd J. Schwedt Tags: American Headache Society Evidence Assessment Source Type: research

Chronic exposure to pollutants in Madín Reservoir (Mexico) alters oxidative stress status and flesh quality in the common carp Cyprinus carpio.
This study aimed to evaluate whether chronic exposure to pollutants in MR alters oxidative stress status and flesh quality in muscle of the common carp Cyprinus carpio. The following biomarkers were evaluated in muscle of carp caught in the general area of discharge from the town of Viejo Madín: hydroperoxide content (HPC), lipid peroxidation (LPX), protein carbonyl content (PCC), and activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Physicochemical and textural properties of muscle were also evaluated. Results show that the metals Al and Fe were accumulated ...
Source: Environmental Science and Pollution Research International - January 14, 2015 Category: Environmental Health Authors: Morachis-Valdez G, Dublán-García O, López-Martínez LX, Galar-Martínez M, Saucedo-Vence K, Gómez-Oliván LM Tags: Environ Sci Pollut Res Int Source Type: research

Optic neuritis in juvenile idiopathic arthritis patient
In conclusion, a low prevalence of ON was observed in our JIA population. The absence of anti-AQP4 antibody and the normal brain MRI do not exclude the possibility of demyelinating disease associated with chronic arthritis. Therefore, rigorous follow up is required. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - January 10, 2015 Category: Rheumatology Source Type: research

Marginally Designed New Profen Analogues Have the Potential to Inhibit Cyclooxygenase Enzymes
The current structure–activity relationship of profens (i.e., 2‐arylpropionic acid derivatives, a class of non‐steroidal anti‐inflammatory drugs) discusses the importance of α‐monomethyl substitution on these compounds, since the activities obtained through their corresponding arylacetic acid derivatives (i.e., α‐demethylated derivatives) or α,α‐dimethyl‐substituted compounds are less than what is observed for the parent profens. Unfortunately, this implies a generalization in structure–activity relationships of profens in such a way that a mono‐(non‐methyl)alkyl group or dialkyl substituent repla...
Source: Archiv der Pharmazie - January 8, 2015 Category: Drugs & Pharmacology Authors: Hayrettin O. Gülcan, Serdar Ünlü, Anatoli Dimoglo, Yasemin Şahin, İlker Esiringu, Tuba Erçetin, Demet Öz, Mustafa F. Şahin Tags: Full Paper Source Type: research

Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis: A Systematic Review and Network Meta-analysis.
CONCLUSION: This method allowed comparison of common treatments of knee OA according to their relative efficacy. Intra-articular treatments were superior to nonsteroidal anti-inflammatory drugs, possibly because of the integrated IA placebo effect. Small but robust differences were observed between active treatments. All treatments except acetaminophen showed clinically significant improvement from baseline pain. This information, along with the safety profiles and relative costs of included treatments, will be helpful for individualized patient care decisions. PRIMARY FUNDING SOURCE: Agency for Healthcare Research and...
Source: Annals of Internal Medicine - January 6, 2015 Category: Internal Medicine Authors: Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE Tags: Ann Intern Med Source Type: research

Primary headache in yemen: prevalence and common medications used.
Conclusion. We concluded that absence of health attention from the Yemeni Community and education from the health system in the country regarding analgesics use and their potential risk led to abuse of such medications and could be a reason beyond high prevalence of headache in Yemen. PMID: 25538854 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - January 3, 2015 Category: Neurology Tags: Neurol Res Int Source Type: research

Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability
Publication date: 30 January 2015 Source:International Journal of Pharmaceutics, Volume 478, Issue 2 Author(s): Benjamin Wuyts , Danny Riethorst , Joachim Brouwers , Jan Tack , Pieter Annaert , Patrick Augustijns The Ussing chambers model is almost exclusively used in the presence of plain aqueous phosphate buffers as solvent system. In an attempt to further elucidate the effect of luminal ingredients and postprandial conditions on intestinal permeability, pooled fasted and fed state human intestinal fluids (FaHIFpool, FeHIFpool) were used. In addition, simulated intestinal fluids of both nutritional states (FaSSIF, FeSS...
Source: International Journal of Pharmaceutics - January 3, 2015 Category: Drugs & Pharmacology Source Type: research

Spontaneous Resolution of Quadrilateral Space Syndrome: A Case Report
ABSTRACTA case of quadrilateral space syndrome is presented, where a large near-circumferential glenoid labrum tear led to a paralabral cyst that dissected into the quadrilateral space and caused a compressive neuropathy of the axillary nerve. This led to a 6-mo history of left shoulder pain, parasthesias, marked weakness to abduction, and marked denervation in both the deltoid and teres minor on electro-diagnostics. This is a presentation of interest as it is the only case report in the literature, to the authors’ knowledge, where spontaneous resolution of entrapment occurred. This normally requires intervention for def...
Source: American Journal of Physical Medicine and Rehabilitation - January 1, 2015 Category: Rehabilitation Tags: Case Reports Source Type: research

The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies.
Abstract The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles ...
Source: Headache - January 1, 2015 Category: Neurology Authors: Marmura MJ, Silberstein SD, Schwedt TJ Tags: Headache Source Type: research

Photochemical properties of gemifloxacin: A laser flash photolysis study
Publication date: Available online 19 December 2014 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): Xu Yulie , Liu Yancheng , Zhao Jianfeng , Li Haixia , Zhang Peng , Wang Wenfeng The photochemical properties of gemifloxacin (GEFX), a fluoroquinolone antibacterial drug that exhibits phototoxicity toward biological substrates, were studied in aqueous solutions by Laser flash photolysis (LFP) and pulse radiolysis. GEFX triplet state (3GEFX∗) absorption spectra showed maximum absorption at 510 nm. 3GEFX∗ was quenched by naproxen (NAP) via energy transfer with a rate constant of 1.2×108 dm3 mol...
Source: Journal of Photochemistry and Photobiology B: Biology - December 25, 2014 Category: Speech Therapy Source Type: research

Optic neuritis in juvenile idiopathic arthritis patient
In conclusion, a low prevalence of ON was observed in our JIA population. The absence of anti-AQP4 antibody and the normal brain MRI do not exclude the possibility of demyelinating disease associated with chronic arthritis. Therefore, rigorous follow up is required. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - December 20, 2014 Category: Rheumatology Source Type: research

Modeling of drug solubility in supercritical carbon dioxide using equation of state based on hole theory with molecular surface charge density
Publication date: December 2014 Source:Chemical Engineering Research and Design, Volume 92, Issue 12 Author(s): Junichi Sakabe , Hirohisa Uchida , Yusuke Shimoyama Equation of state based on hole theory with molecular surface charge density was developed for the modeling of drug solubility in supercritical carbon dioxide. In the hole theory, the density change of supercritical carbon dioxide can be represented by the number of holes in the system. The molecular interaction energy parameter was estimated using the interactions of segments on the molecular surface given by a quantum calculation using conductor-like screeni...
Source: Chemical Engineering Research and Design - December 8, 2014 Category: Chemistry Source Type: research

Pharmacokinetic Comparison Study of a Combination Containing 500 mg of Naproxen and 20 mg of Esomeprazole: A Randomized, Single-Dose, 2-Way Crossover, Open-Label Study in Healthy Korean Men.
This study was performed for the subsequent marketing of a combination drug that contained 500 mg of naproxen and 20 mg of esomeprazole in Korea. We evaluated the comparative bioavailability and tolerability of the test and reference formulations in healthy men. METHODS: A total of 60 healthy men were enrolled in this single-dose, randomized, open-label, 2-period, 2-sequence, crossover study. During each period, men received a combination of 500 mg of naproxen and 20 mg of esomeprazole for test or reference, and between each period, there was a 1-week washout period. Blood samples were obtained 21 times throughout each...
Source: Clinical Therapeutics - December 4, 2014 Category: Drugs & Pharmacology Authors: Choi HG, Jeon JY, Kwak SS, Kim H, Jin C, Im YJ, Kim EY, Wang HM, Kim Y, Lee SY, Kim MG Tags: Clin Ther Source Type: research

Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice
Conclusions: These data demonstrate that ATB-346 can be efficacious in a TBI animal model by reducing the secondary inflammation and tissue injury. Therefore, ATB-346 could represent an interesting approach for the management of secondary damage following CNS diseases, counteracting behavioral changes and inflammatory process. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 4, 2014 Category: Neurology Authors: Michela CampoloEmanuela EspositoAkbar AhmadRosanna Di PaolaIrene PaternitiMarika CordaroGiuseppe BruschettaJohn WallaceSalvatore Cuzzocrea Source Type: research

Efficacy of etoricoxib, celecoxib, lumiracoxib, non-selective NSAIDs, and acetaminophen in osteoarthritis: a mixed treatment comparison.
CONCLUSION: The current study estimated the efficacy of acetaminophen, nsNSAIDs, and COX-2 selective NSAIDs in OA and found that etoricoxib 30 mg is likely to result in the greatest improvements in pain and physical function. Differences in PGADS between interventions were smaller. PMID: 22582102 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - December 2, 2014 Category: Rheumatology Tags: Open Rheumatol J Source Type: research

Comparison of the effect of Naproxen, Etodolac and Diclofenac on postoperative sequelsfollowing third molar surgery: a randomised, double-blind, crossover study.
CONCLUSION: NSAIDs (Diclofenac, Naproxen and Etodolac) are somehow similarly effective for controlling pain and trismus following extraction of mandibular third molars but Diclofenac potassium surpasses others in reduction of swelling. PMID: 24316711 [PubMed - in process] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - December 2, 2014 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research

Undetected Ultracet™ dependence in an adolescent with nonmalignant back pain.
This report discusses an 18-year-old woman with idiopathic scoliosis and clinical depression secondary to undertreated refractory chronic back pain who underwent surgery to correct pseudoarthrosis after a prior spinal instrumentation operation. This intervention in conjunction with a course of patient-controlled analgesia, hydromorphone, and outpatient tramadol, naproxen, methadone, and gabapentin was successful in addressing her long-standing lumbar pain. The patient, however, continued to complain to her pain management team of postsurgical discomfort and insisted on being prescribed Ultracet™ (acetaminophen-tramadol) ...
Source: Journal of Opioid Management - December 2, 2014 Category: Addiction Tags: J Opioid Manag Source Type: research

Functional Adrenal Insufficiency Complicating an Overdose of Naproxen and Ibuprofen
(Source: Clinical Pediatrics)
Source: Clinical Pediatrics - December 2, 2014 Category: Pediatrics Authors: Akingbola, O. A., Singh, D., Kleinman, J. A., Frieberg, E. M. Tags: Brief Reports Source Type: research

Pharmacological modulation of hand pain in osteoarthritis: A double‐blinded placebo‐controlled functional magnetic resonance imaging study using naproxen
Conclusion This study demonstrates the sensitivity of fMRI to detect the mechanisms underlying treatments of known efficacy. These data illustrate the enticing potential of fMRI as an adjunct to self‐report for detecting early signals of efficacy for novel therapies, both pharmacological and non‐pharmacological, in small numbers of individuals suffering persistent pain. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 1, 2014 Category: Rheumatology Authors: Duncan Sanders, Kristina Krause, Jonathan O'Muircheartaigh, Michael A. Thacker, John P. Huggins, Bill Vennart, Nathalie J. Massat, Ernest Choy, Steven C.R. Williams, Matthew A. Howard Tags: Full Length Source Type: research

Screening of non‐steroidal anti‐inflammatory drugs for inhibitory effects on the activities of six UDP‐glucuronosyltransferases (UGT1A1, 1A3, 1A4, 1A6, 1A9, and 2B7) using LC‐MS/MS
This article is protected by copyright. All rights reserved. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - December 1, 2014 Category: Drugs & Pharmacology Authors: Jeongmin Joo, Yang‐Weon Kim, Zhexue Wu, Jung‐Hoon Shin, Boram Lee, Jong Cheol Shon, Eun Young Lee, Nguyen Minh Phuc, Kwang‐Hyeon Liu Tags: Short Communication Source Type: research

Competitive adsorption of selected non-steroidal anti-inflammatory drugs on activated biochars: Experimental and molecular modeling study
Publication date: 15 March 2015 Source:Chemical Engineering Journal, Volume 264 Author(s): Chanil Jung , Linkel K. Boateng , Joseph R.V. Flora , Jeill Oh , Marcus C. Braswell , Ahjeong Son , Yeomin Yoon The adsorption of targeted non-steroidal anti-inflammatory drugs: diclofenac (DCF), naproxen (NPX), and ibuprofen (IBP) by two types of activated biochar (N-/O-biochar) was studied in single- and multi-solute adsorption experiments in conjunction with molecular modeling subsequently interpreting the binding energy. The carbonaceous structure of the biochars was elucidated via nuclear magnetic resonance and the intensity o...
Source: Chemical Engineering Journal - December 1, 2014 Category: Chemistry Source Type: research

Double-blind, placebo-controlled, crossover study of early-intervention with sumatriptan 85/naproxen sodium 500 in (truly) episodic migraine: what's neck pain got to do with it?
CONCLUSION: Our study results support a fundamental re-evaluation of the role of neck pain in migraine. PMID: 24685971 [PubMed - indexed for MEDLINE] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - November 28, 2014 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Comparison of the postoperative analgesic effects of naproxen sodium and naproxen sodium-codeine phosphate for arthroscopic meniscus surgery
Conclusions The combination of naproxen sodium-codeine phosphate provided more effective analgesia than naproxen sodium and did not increase side effects. (Source: Brazilian Journal of Anesthesiology)
Source: Brazilian Journal of Anesthesiology - November 28, 2014 Category: Anesthesiology Source Type: research

Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial
Conclusions Paracetamol/CR oxycodone and paracetamol/naproxen are equally effective in treatment of acute postoperative pain at home after ambulatory surgery with comparable patient satisfaction level. We suggest paracetamol/CR oxycodone to be a valuable alternative for the current paracetamol/naproxen gold standard, particularly in patients with a contraindication for nonsteroidal anti-inflammatory drugs. ClinicalTrials.gov identifier: NCT02152592. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 28, 2014 Category: Drugs & Pharmacology Source Type: research

Aspirin-dependent cyclooxygenase acetylation [Medical Sciences]
The cardiovascular safety of nonsteroidal antiinflammatory drugs (NSAIDs) may be influenced by interactions with antiplatelet doses of aspirin. We sought to quantitate precisely the propensity of commonly consumed NSAIDs—ibuprofen, naproxen, and celecoxib—to cause a drug–drug interaction with aspirin in vivo by measuring the target engagement of aspirin directly by MS.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 25, 2014 Category: Science Authors: Li, X., Fries, S., Li, R., Lawson, J. A., Propert, K. J., Diamond, S. L., Blair, I. A., FitzGerald, G. A., Grosser, T. Tags: Biological Sciences Source Type: research

Hydrogen sulphide protects against NSAID‐enteropathy through modulation of bile and the microbiota
Conclusions and ImplicationsHydrogen sulphide protects against NSAID‐enteropathy in rats, in part reducing the cytotoxicity of bile and preventing NSAID‐induced dysbiosis. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: Rory W Blackler, Jean‐Paul Motta, Anna Manko, Matthew Workentine, Premysl Bercik, Michael G Surette, John L Wallace Tags: RESEARCH PAPER Source Type: research

Atrial fibrillation in patients undergoing surgical revascularization: an update on pharmacologic prophylaxis.
Authors: Rostagno C Abstract Atrial fibrillation occurs in 20-50% of patients after surgical revascularization (40% have more than 1 episode), with a peak between 2nd and 3rd postoperative days. Postoperative atrial fibrillation (POAF) has been associated with an increase in adverse events, length of hospital stay and, therefore, cost of care, and late mortality. A higher risk profile in patients who develop POAF may contribute to the higher late mortality rate. The pathogenesis of PAOF is multi factorial: transient ischemia during surgical procedure, neurohormonal activation, electrolyte imbalance, fluid overload ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Characterization of cefalexin degradation capabilities of two Pseudomonas strains isolated from activated sludge
Publication date: 23 January 2015 Source:Journal of Hazardous Materials, Volume 282 Author(s): Bokun Lin , Jinling Lyu , Xian-jin Lyu , Han-qing Yu , Zhong Hu , James C.W. Lam , Paul K.S. Lam Pharmaceuticals have recently been regarded as contaminants of emerging concern. To date, there is limited knowledge about antibiotic-degrading microorganisms in conventional activated sludge treatment systems and their characteristics toward antibiotic degradation especially in the presence of a pharmaceutical mixture. As such, antibiotic-degrading microorganisms were investigated and isolated from the activated sludge, and their d...
Source: Journal of Hazardous Materials - November 21, 2014 Category: Environmental Health Source Type: research

Molecular Dynamics Simulations of Complex Mixtures Aimed at the Preparation of Naproxen-Imprinted Xerogels
Journal of Chemical Information and ModelingDOI: 10.1021/ci5004575 (Source: Journal of Chemical Information and Modeling)
Source: Journal of Chemical Information and Modeling - November 19, 2014 Category: Chemistry Authors: Riccardo Concu, Martin Perez, M. Natália D. S. Cordeiro and Manuel Azenha Source Type: research

Assessment of organotins against the linoleic acid, glutathione and CT-DNA
Publication date: 1 November 2014 Source:Inorganica Chimica Acta, Volume 423, Part B Author(s): C.N. Banti , E.I. Gkaniatsou , N. Kourkoumelis , M.J. Manos , A.J. Tasiopoulos , T. Bakas , S.K. Hadjikakou The already known di-n-butyltin(IV) complex of the chiral anti-inflammatory drug naproxen (Hnapr) of formula [(n-Bu-)2Sn(nap)2] (1), was re-synthesized here with an alternative method and it was used for the assessment of organotins towards the linoleic acid which is located in the cell membrane, the intracellular glutathione and the nuclear CT-DNA. The compound was characterized by melting point (m.p.) 119Sn Mössbauer ...
Source: Inorganica Chimica Acta - November 17, 2014 Category: Chemistry Source Type: research

Electrochemically controlled in-tube solid phase microextraction of naproxen from urine samples using an experimental design
Analyst, 2015, Advance ArticleDOI: 10.1039/C4AN01664E, PaperSeyyed Hamid Ahmadi, Ahmad Manbohi, Kourosh Tabar HeydarElectrochemically controlled in-tube SPME approach, which increased the sensitivity and decreased the extraction time, was reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - November 15, 2014 Category: Chemistry Authors: Seyyed Hamid Ahmadi Source Type: research

Naproxen Attenuates Sensitization of Depressive-Like Behavior and Fever during Maternal Separation
Publication date: Available online 14 November 2014 Source:Physiology & Behavior Author(s): Michael B. Hennessy , Nathan P. Stafford , Brittany Yusko-Osborne , Patricia A. Schiml , Evan D. Xanthos , Terrence Deak Early life stress can increase susceptibility for later development of depressive illness though a process thought to involve inflammatory mediators. Isolated guinea pig pups exhibit a passive, depressive-like behavioral response and fever that appear mediated by proinflammatory activity, and which sensitize with repeated separations. Treatment with an anti-inflammatory can attenuate the behavioral respo...
Source: Physiology and Behavior - November 14, 2014 Category: Physiology Source Type: research

Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
Publication date: 5 December 2014 Source:Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 463 Author(s): R. Rojas , A.F. Jimenez-Kairuz , R.H. Manzo , C.E. Giacomelli This work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceed...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - November 14, 2014 Category: Chemistry Source Type: research