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Model‐based prediction of the acute and long‐term safety profile of naproxen in rats
Conclusions and ImplicationsThese results show that the use of a model‐based approach provides the opportunity to integrate pharmacokinetics, pharmacodynamics and toxicity data, enabling optimisation of the design, analysis and interpretation of toxicology experiments. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - April 17, 2015 Category: Drugs & Pharmacology Authors: Tarjinder Sahota, Ian Sanderson, Meindert Danhof, Oscar Della Pasqua Tags: Research Paper Source Type: research

Formulation and process optimization of naproxen nanosuspensions stabilized by hydroxy propyl methyl cellulose
Publication date: 20 August 2015 Source:Carbohydrate Polymers, Volume 127 Author(s): Bibaswan Mishra , Jagannath Sahoo , Prasanna Kumar Dixit In present study precipitation–ultrasonication was used to obtain nanosuspensions of poorly water-soluble drug, naproxen (NPX). We investigated the effects of HPMC concentration (X1) and time of ultrasonication (X2) on imperative attributes like mean particle size (Y1), % drug content (Y2), and time required to 90% drug release (Y3) via 32 factorial design. The morphology of nanosuspensions was found almost spherical by SEM observation. DSC and XRD studies suggested slight crysta...
Source: Carbohydrate Polymers - April 17, 2015 Category: Biomedical Science Source Type: research

Consistency of Response to Sumatriptan/Naproxen Sodium in a Randomized Placebo‐Controlled, Cross‐Over Study for the Acute Treatment of Migraine in Adolescence
The objective of this study was to examine the efficacy of S/NS vs placebo in the primary end‐points of pain‐free response at 2 hours (2hPF), 24‐hour sustained pain‐free response (24hPF), and pain‐free response at 2 hours with early intervention (2hPFE) calculated as percentage out of all attacks. In the study, 94 subjects treated 347 attacks in total: treating 277 with S/NS and 70 with placebo. Compared with placebo, S/NS produced higher 2hPF rates (S/NS 37%, placebo 18%; P < .004), and 2hPFE with rates (S/NS 32%, 18% placebo; P < .03). Compared with placebo, 24hPF rates were S/NS 86%, placebo 78%,...
Source: Headache: The Journal of Head and Face Pain - April 17, 2015 Category: Neurology Authors: Paul Winner, Steven Linder, Andrew D. Hershey Tags: Research Submission Source Type: research

Comment on “Purity Analysis of the Pharmaceuticals Naproxen and Propranolol: A Guided-Inquiry Laboratory Experiment in the Analytical Chemistry Laboratory”
Journal of Chemical EducationDOI: 10.1021/acs.jchemed.5b00133 (Source: Journal of Chemical Education)
Source: Journal of Chemical Education - April 16, 2015 Category: Chemistry Authors: Alan M. Rosan Source Type: research

Deciphering the Pathogenesis of NSAID-Enteropathy Using Proton Pump Inhibitors and a Hydrogen Sulfide-Releasing NSAID.
Abstract The small intestine is a significant site of ulceration and bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The pathogenesis is poorly understood. The present study explored the roles of bile, bacteria and enterohepatic circulation to NSAID-enteropathy, using both a conventional NSAID (naproxen) and a gastrointestinal-safe naproxen derivative (ATB-346), as well as proton pump inhibitors. Rats were treated orally with naproxen or equimolar doses of ATB-346 over a 5-day period, with or without PPI administration, and intestinal damage was quantified. The cytotoxicity of bile from the rats ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 16, 2015 Category: Physiology Authors: Blackler RW, De Palma G, Manko A, Da Silva GJ, Flannigan KL, Bercik P, Surette MG, Buret AG, Wallace JL Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Acute Migraine Treatment in Adults.
This study aims to review current medical office-based acute migraine therapy in adults and provides readers with an organized approach to this important facet of migraine treatment. A general literature review includes a review of several recent published guidelines. Acetaminophen, 4 nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, acetylsalicylic acid [ASA], naproxen sodium, and diclofenac potassium), and 7 triptans (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan) have good evidence for efficacy and form the core of acute migraine treatment. NSAID-triptan combinati...
Source: Headache - April 15, 2015 Category: Neurology Authors: Becker WJ Tags: Headache Source Type: research

Acute Migraine Treatment in Adults
This study aims to review current medical office‐based acute migraine therapy in adults and provides readers with an organized approach to this important facet of migraine treatment. A general literature review includes a review of several recent published guidelines. Acetaminophen, 4 nonsteroidal anti‐inflammatory drugs (NSAIDs) (ibuprofen, acetylsalicylic acid [ASA], naproxen sodium, and diclofenac potassium), and 7 triptans (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan) have good evidence for efficacy and form the core of acute migraine treatment. NSAID–triptan com...
Source: Headache: The Journal of Head and Face Pain - April 15, 2015 Category: Neurology Authors: Werner J. Becker Tags: Review Article Source Type: research

Hydrogel with a basic instinct for drug delivery
Gel that releases naproxen in alkaline surroundings is promising step toward relieving drug’s side effects (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - April 15, 2015 Category: Chemistry Authors: Christopher Barnard Source Type: research

Pharmaceuticals and iodinated contrast media in a hospital wastewater: A case study to analyse their presence and characterise their environmental risk and hazard.
Abstract This work analyses the presence of twenty-five pharmaceutical compounds belonging to seven different therapeutic groups and one iodinated contrast media (ICM) in a Spanish medium-size hospital located in the Valencia Region. Analysis of the target compounds in the hospital wastewater was performed by means of solid phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry analysis (HPLC-MS/MS). A screening level risk assessment combining the measured environmental concentrations (MECs) with dose-response data based on Predicted No Effect Concentration (PNEC) was also applied to esti...
Source: Environmental Research - April 10, 2015 Category: Environmental Health Authors: Mendoza A, Aceña J, Pérez S, López de Alda M, Barceló D, Gil A, Valcárcel Y Tags: Environ Res Source Type: research

Alexia with agraphia as a rare presentation of migraine (P1.309)
CONCLUSIONS:This represents the first-ever case report of alexia with agraphia presenting as migraine aura. The pathophysiology of cortical spreading depression within migraine auras easily supports cortical dysfunction of the angular gyrus preceding or during a migraine attack.Disclosure: Dr. Suhaib has nothing to disclose. Dr. Vaughn has received personal compensation for activities with various multiple sclerosis surveys. (Source: Neurology)
Source: Neurology - April 8, 2015 Category: Neurology Authors: Suhaib, O., Vaughn, A. Tags: Headache I Source Type: research

Individual non-steroidal anti-inflammatory drugs and risk of acute kidney injury: A systematic review and meta-analysis of observational studies.
CONCLUSION: A statistically significant elevated AKI risk among traditional NSAID users has been demonstrated in this meta-analysis. The pooled risk ratios among individual traditional NSAIDs were not significantly different. The pooled risk ratios of specific COX-2 inhibitors and the two traditional NSAIDs with the most COX-2 selectivity (diclofenac and meloxicam) were also comparable with other traditional NSAIDs even though they did not achieve a statistical significance. PMID: 25862494 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 7, 2015 Category: Internal Medicine Authors: Ungprasert P, Cheungpasitporn W, Crowson CS, Matteson EL Tags: Eur J Intern Med Source Type: research

Optimization and dissolution performance of spray-dried naproxen nano-crystals
Publication date: 30 May 2015 Source:International Journal of Pharmaceutics, Volume 486, Issues 1–2 Author(s): Sumit Kumar , Jie Shen , Banu Zolnik , Nakissa Sadrieh , Diane J. Burgess The purpose of this study was to investigate the in vitro dissolution performance of the different sized spray-dried nano-crystalline powders of naproxen. A DoE approach was used to formulate and optimize nano-crystalline suspensions. The critical wet milling operation parameters were i.e., drug concentration, drug-to-stabilizer ratio, stabilizer type (HPMC E15 or Tween 80) and milling intensity. The nano-crystalline suspensions were opt...
Source: International Journal of Pharmaceutics - April 6, 2015 Category: Drugs & Pharmacology Source Type: research

Ictal adipokines are associated with pain severity and treatment response in episodic migraine
Conclusions: Both pretreatment migraine pain severity and treatment response are associated with changes in adipokine levels. Adipokines represent potential novel migraine biomarkers and drug targets. (Source: Neurology)
Source: Neurology - April 6, 2015 Category: Neurology Authors: Chai, N. C., Gelaye, B., Tietjen, G. E., Dash, P. D., Gower, B. A., White, L. W., Ward, T. N., Scher, A. I., Peterlin, B. L. Tags: Migraine, All Pain ARTICLE Source Type: research

NSAIDs and spontaneous abortions – true effect or an indication bias?
ConclusionsThe increased use of NSAIDs during the last few days that preceded a spontaneous abortion to relieve pain associated with the miscarriage could bias studies assessing the association between exposure to NSAIDs and spontaneous abortions. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - April 6, 2015 Category: Drugs & Pharmacology Authors: Sharon Daniel, Gideon Koren, Eitan Lunenfeld, Amalia Levy Tags: Methods in clinical pharmacology Source Type: research

Oral analgesia for relieving post-caesarean pain.
CONCLUSIONS: Eight trials with 962 women were included in the analysis, but only four trials were of high quality. All the trials were small. We carried out subgroup analysis for different drugs within the same group and for high versus low doses of the same drug. However, the relatively few studies (one to two trials) and numbers of women (40 to 136) limits the reliability of these subgroup analyses.Due to limited data available no conclusions can be made regarding the safest and the most effective form of oral analgesia for post-caesarean pain. Further studies are necessary. PMID: 25821010 [PubMed - in process] (Sour...
Source: Cochrane Database of Systematic Reviews - April 2, 2015 Category: Journals (General) Authors: Mkontwana N, Novikova N Tags: Cochrane Database Syst Rev Source Type: research

Is Ultrasound Guidance Needed for Shoulder Injections?
MJ is a 44-year-old teacher who has had right lateral shoulder pain for 5 weeks. The pain developed acutely after he played a pickup game of basketball. He initially presented to his primary care physician, who suspected an acute rotator cuff injury and prescribed naproxen, 500 mg twice daily, along with physical therapy. MJ has completed 4 weeks of appropriate therapy focusing on scapular retraction exercise, pectoralis stretching, and rotator cuff strengthening. He experienced no relief from the therapy or medication, so his primary care physician obtained a shoulder magnetic resonance (MR) arthrogram, which demonstrated...
Source: PM and R - April 1, 2015 Category: Rehabilitation Authors: Jonathan T. Finnoff, John G. Costouros, David J. Kennedy Tags: Point/Counterpoint Source Type: research

Naproxen Prevention of Urinary Bladder Cancer
The COX inhibitors (NSAID/Coxibs) are a major focus for the chemoprevention of cancer. The COX-2–specific inhibitors have progressed to clinical trials and have shown preventive efficacy in colon and skin cancers. However, they have significant adverse cardiovascular effects. Certain NSAIDs (e.g., naproxen) have a good cardiac profile, but can cause gastric toxicity. The present study examined protocols to reduce this toxicity of naproxen. Female Fischer-344 rats were treated weekly with the urinary bladder–specific carcinogen hydroxybutyl(butyl)nitrosamine (OH-BBN) for 8 weeks. Rats were dosed daily with NPX (...
Source: Cancer Prevention Research - March 31, 2015 Category: Cancer & Oncology Authors: Lubet, R. A., Scheiman, J. M., Bode, A., White, J., Minasian, L., Juliana, M. M., Boring, D. L., Steele, V. E., Grubbs, C. J. Tags: Research Articles Source Type: research

(401) Analgesic effectiveness of a new, extended-release ibuprofen in postoperative dental pain
Analgesic effects of an immediate-release/extended-release (IR/ER) 600 mg formulation of ibuprofen (IBU) with q12h dosing were evaluated in 2 single-center, randomized, double-blind, placebo-controlled dental pain studies (Study 1: single dose, 24-hour study; Study 2: multiple doses, 48-hour study). Subjects aged 16–40 years with at least moderate pain following third molar extraction received single doses of 2 IBU 600 mg IR/ER formulations (A or B), naproxen sodium (NAP) 220 mg, or placebo (2:2:2:1 ratio) in Study 1; 4 doses IBU 600 mg IR/ER or placebo (1:1 ratio) in Study 2. (Source: The Journal of Pain)
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: S. Christensen, S. Meeves, S. Jayawardena, S. Daniels, E. Paluch Source Type: research

Influence of excipients on solubility and dissolution of pharmaceuticals
Publication date: 15 May 2015 Source:International Journal of Pharmaceutics, Volume 485, Issues 1–2 Author(s): Raphael Paus , Anke Prudic , Yuanhui Ji In this work, solubilities and dissolution profiles of the active pharmaceutical ingredients (APIs) indomethacin and naproxen were measured in water in the presence of one excipient out of polyethylene glycol (PEG) 2000, 6000 and 12000, polyvinylpyrrolidone (PVP) K 25 and mannitol. It was found that the solubility of indomethacin and naproxen was increased with an addition of the selected excipients, which was also predicted by the perturbed-chain statistical associating...
Source: International Journal of Pharmaceutics - March 27, 2015 Category: Drugs & Pharmacology Source Type: research

A multiresidue liquid chromatographic/tandem mass spectrometric method for the detection and quantitation of 15 nonsteroidal anti-inflammatory drugs (NSAIDs) in bovine meat and milk.
This study concerns a validated liquid chromatographic/tandem mass spectrometric (LC-MS/MS) multiresidue method for the simultaneous detection, identification, and quantitation of 15 nonsteroidal anti-inflammatory drugs (NSAIDs) in bovine meat and milk. The NSAIDs considered are carprofen, diclofenac, flufenamic acid, flunixin (5-hydroxyflunixin as marker metabolite in milk), ketoprofen, mefenamic acid, meloxicam, 4-methylaminoantipyrine (marker metabolite of metamizole in meat and milk), naproxen, niflumic acid, phenylbutazone (and metabolite oxyphenbutazone), ramifenazone, salicylic acid, and tolfenamic acid. These compo...
Source: Analytical and Bioanalytical Chemistry - March 27, 2015 Category: Chemistry Authors: van Pamel E, Daeseleire E Tags: Anal Bioanal Chem Source Type: research

Modulation of intestinal afferent nerve sensitivity to inflammatory mediators following systemic endotoxin in mice
Conclusions & InferencesSystemic endotoxin sensitizes mesenteric afferent nerve fibers to 5‐HT, BK and mechanical stimuli. The underlying mechanism responsible for this sensitization seems to involve mast cells and the COX‐2 pathway. Endotoxin sensitizes intestinal afferent nerves in mice in vitro to 5‐HT, bradykinin and mechanical ramp distension. This sensitization was dependent on mast cells and the COX‐2 but not to the COX‐1 pathway. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 26, 2015 Category: Gastroenterology Authors: B. Xue, M. S. Kasparek, M. H. Müller, M. E. Kreis Tags: Original Article Source Type: research

Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins.
This study compared the extent, affinity, and kinetics of drug binding to human serum albumin (HSA) and liver fatty acid binding protein (LFABP) using ultrafiltration and surface plasmon resonance (SPR). 2. Binding of basic and neutral drugs to both HSA and LFABP was typically negligible. Binding of acidic drugs ranged from minor (fu > 0.8) to extensive (fu < 0.1). Of the compounds screened, the highest binding to both HSA and LFABP was observed for the acidic drugs torsemide and sulfinpyrazone, and for β-estradiol (a polar, neutral compound). 3. The extent of binding of acidic drugs to HSA was up to 40%...
Source: Xenobiotica - March 24, 2015 Category: Research Authors: Rowland A, Hallifax D, Nussio MR, Shapter JG, Mackenzie PI, Brian Houston J, Knights KM, Miners JO Tags: Xenobiotica Source Type: research

Formulation and evaluation of ileo-colonic targeted matrix-mini-tablets of Naproxen for Chronotherapeutic treatment of Rheumatoid Arthritis
Publication date: Available online 20 March 2015 Source:Saudi Pharmaceutical Journal Author(s): Mohd Abdul Hadi , N.G. Raghavendra Rao , A Srinivasa Rao In this present research work, the aim was to develop ileo-colonic targeted matrix-mini-tablets-filled capsule system of Naproxen for chronotherapeutic treatment of Rheumatoid Arthritis. So Matrix-mini-tablets of Naproxen were prepared using microsomal enzyme dependent and pH-sensitive polymers by direct compression method which were further filled into an empty HPMC capsule. The compatibility was assessed using FT-IR and DSC studies for pure drug, polymers and their phy...
Source: Saudi Pharmaceutical Journal - March 21, 2015 Category: Drugs & Pharmacology Source Type: research

Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis
Conclusions: The benefit-risk profile of diclofenac was comparable to other treatments used for pain relief in OA and RA; benefits and risks vary in individuals and need consideration when making treatment decisions. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 19, 2015 Category: Rheumatology Authors: Anneloes van WalsemShaloo PandhiRichard NixonPatricia GuyotAndreas KarabisR Moore Source Type: research

Characterization of naproxen-loaded solid SMEDDSs prepared by spray drying: The effect of the polysaccharide carrier and naproxen concentration
Publication date: 15 May 2015 Source:International Journal of Pharmaceutics, Volume 485, Issues 1–2 Author(s): Katja Čerpnjak , Alenka Zvonar , Franc Vrečer , Mirjana Gašperlin The purpose of this study was to prepare solid SMEDDS (sSMEDDS) particles produced by spray-drying using maltodextrin (MD), hypromellose (HPMC), and a combination of the two as a solid carrier. Naproxen (NPX) as the model drug was dissolved (at 6% concentration) or partially suspended (at 18% concentration) in a liquid SMEDDS composed of Miglyol® 812, Peceol™, Gelucire® 44/14, and Solutol® HS 15. Among the sSMEDDSs tested, the MD-based s...
Source: International Journal of Pharmaceutics - March 19, 2015 Category: Drugs & Pharmacology Source Type: research

Relationship Between Structural Alerts in NSAIDs and Idiosyncratic Hepatotoxicity: An Analysis of Spontaneous Report Data from the WHO Database
Conclusions This study shows that although spontaneous reports have many limitations, the findings are in line with previous research on the reactive metabolite concept. Whether SAs and the number of SAs in the NSAIDs actually play a role in the observed hepatotoxicity must be investigated in future studies. (Source: Drug Safety)
Source: Drug Safety - March 19, 2015 Category: Drugs & Pharmacology Source Type: research

Changes in the solid state of anhydrous and hydrated forms of sodium naproxen under different grinding and environmental conditions: Evidence of the formation of new hydrated forms.
Abstract The aim of the present work was to investigate the solid state change of the anhydrous and hydrate solid forms of sodium naproxen under different grinding and environmental conditions. Grinding was carried out manually in a mortar under the following conditions: at room temperature under air atmosphere (Method A), in the presence of liquid nitrogen under air atmosphere (Method B), at room temperature under nitrogen atmosphere (Method C), and in presence of liquid nitrogen under nitrogen atmosphere (Method D). Among the hydrates, the following forms were used: a dihydrate form (DSN) obtained by exposing the...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 18, 2015 Category: Drugs & Pharmacology Authors: Censi R, Rascioni R, Martino PD Tags: Eur J Pharm Biopharm Source Type: research

Using gait analysis to assess weight bearing in rats with Freund's complete adjuvant-induced monoarthritis to improve predictivity: Interfering with the cyclooxygenase and nerve growth factor pathways.
Abstract Lack of predictive power for drug effects has been a major criticism against animal pain models. It is therefore important to define the utility and limitations of different models. The aim of this study was to extend previous work on gait analysis as a tool to investigate pharmacological effects in monoarthritic rats, specifically to test the hypothesis that monoarthritis induced by Freund's complete adjuvant (FCA) provides a better estimate of overall analgesic efficacy of established, and novel, clinically effective and ineffective therapeutic approaches. Male rats injected intra-articularly into one an...
Source: European Journal of Pharmacology - March 16, 2015 Category: Drugs & Pharmacology Authors: Ängeby Möller K, Berge OG, Finn A, Stenfors C, Svensson CI Tags: Eur J Pharmacol Source Type: research

Effects of various factors of ultrasonic treatment on the extraction recovery of drugs from fish tissues.
Abstract In the present research, a combined extraction method of ultrasound-assisted extraction (UAE) in conjunction with solid phase extraction (SPE) was applied to isolation and enrichment of selected drugs (metoprolol, ticlopidine, propranolol, carbamazepine, naproxen, acenocumarol, diclofenac, ibuprofen) from fish tissues. The extracted analytes were separated and determined by ultra-high performance liquid chromatography with UV detection (UHPLC-UV) technique. The selectivity of the developed UHPLC-UV method was confirmed by comparison with ultra-high performance liquid chromatography-tandem mass spectrometry...
Source: Ultrasonics Sonochemistry - March 12, 2015 Category: Chemistry Authors: Magiera S, Pardylla A, Baranowska I Tags: Ultrason Sonochem Source Type: research

Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen
Publication date: 1 April 2015 Source:Life Sciences, Volume 126 Author(s): Angela Amoruso , Luigia Grazia Fresu , Jesmond Dalli , Daniela Miglietta , Claudio Bardelli , Donata Federici Canova , Mauro Perretti , Sandra Brunelleschi Aims Cyclooxygenase (COX)-inhibiting nitric oxide donors (CINODs) are a new class of drugs that structurally combine a COX inhibitor with a nitric oxide (NO) donating moiety. This combination reduces potential toxicity of the non-steroidal anti-inflammatory drugs (NSAIDs) whilst maintaining the analgesic and anti-inflammatory effects. The present study was undertaken to investigate the anti-inf...
Source: Life Sciences - March 11, 2015 Category: Biology Source Type: research

Process Parameter Dependent Growth Phenomena during the Fine Grinding of Naproxen in a Planetary Ball Mill.
Abstract The production of nanosuspensions has proved to be an effective method for overcoming bioavailability challenges of poorly water soluble drugs. Wet milling in stirred media mills and planetary ball mills has become an established top-down-method for producing such drug nanosuspensions. The quality of the resulting nanosuspension is determined by the stability against agglomeration on the one hand, and the process parameters of the mill on the other hand. In order to understand the occurring dependencies, a detailed screening study, not only on adequate stabilizers, but also on their optimum concentration w...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 9, 2015 Category: Drugs & Pharmacology Authors: Bitterlich A, Laabs C, Krautstrunk I, Dengler M, Juhnke M, Grandeury A, Bunjes H, Kwade A Tags: Eur J Pharm Biopharm Source Type: research

Fabric phase sorptive extraction: A new sorptive microextraction technique for the determination of non-steroidal anti-inflammatory drugs from environmental water samples.
Abstract Fabric phase sorptive extraction (FPSE) is a new, yet very promising member of the sorbent-based sorptive microextraction family. It has simultaneously improved both the extraction sensitivity and the speed of the extraction by incorporating high volume of sol-gel hybrid inorganic-organic sorbents into permeable fabric substrates. The advantages of FPSE have been investigated for the determination of four non-steroidal anti-inflammatory drugs, ibuprofen, naproxen, ketoprofen and diclofenac, in environmental water samples in combination with gas chromatography-mass spectrometry. Initially, the significance ...
Source: Analytica Chimica Acta - March 7, 2015 Category: Chemistry Authors: Racamonde I, Rodil R, Quintana JB, Sieira BJ, Kabir A, Furton KG, Cela R Tags: Anal Chim Acta Source Type: research

Anomalous Role Change of Tertiary Amino and Ester Groups as Hydrogen Acceptors in Eudragit E Based Solid Dispersion Depending on the Concentration of Naproxen
Molecular PharmaceuticsDOI: 10.1021/mp5005417 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - March 3, 2015 Category: Drugs & Pharmacology Authors: Hiroshi Ueda, Shinobu Wakabayashi, Junko Kikuchi, Yasuo Ida, Kazunori Kadota and Yuichi Tozuka Source Type: research

Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study
Conclusions Treatment for 1 to 3 years with naproxen or celecoxib did not protect against cognitive decline in older adults with a family history of AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 2, 2015 Category: Geriatrics Source Type: research

[Cardiovascular safety of non-steroidal anti-inflammatory drugs].
Abstract BACKGROUND The selective cyclooxygenase (COX)-2 inhibitor rofecoxib was withdrawn from the market in 2004 due to cardiovascular toxicity. We have evaluated data on adverse cardiovascular effects caused by COX-2 inhibitors and other non-steroidal anti-inflammatory drugs (NSAIDs) since 2004.MATERIAL AND METHOD Searches in PubMed (2004-2014) identified 243 relevant articles. Following a selection process, 63 articles were reviewed and evaluated in light of Norwegian practice.RESULTS The results from the studies reviewed are heterogenous. A majority of data indicate that all the selective COX-2 inhibitors, dic...
Source: Tidsskrift for den Norske Laegeforening - March 1, 2015 Category: Journals (General) Authors: Møllersen MV, Norgård H, Spigset O, Slørdal L Tags: Tidsskr Nor Laegeforen Source Type: research

The H 2 S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis
Conclusion The H2S-releasing moiety in the ATB-346 compound not only does not impair the effects of the parent naproxen on periodontitis, but also improves bone quality and prevents the gastric mucosa damage due to prostaglandin inhibition, thus configuring a potentially new adjuvant therapy for periodontal diseases. (Source: Medical Gas Research)
Source: Medical Gas Research - February 27, 2015 Category: Biomedical Science Source Type: research

Sensing of enantiomeric excess in chiral carboxylic acids.
Abstract Cinchona alkaloids (quinine, quinidine, cinchonine, cinchonidine) alkylated at N(1) with chloromethyl anthracene can serve as fluorescent sensors for chiral carboxylic acids. These cinchona ammonium salts are shown to bind chiral carboxylic acids while displaying an increase in fluorescence intensity that can be utilized in determination of enantiomeric excess (ee). Sensor arrays composed of four cinchona ammonium salts are used for quantitative analysis of ee in several non-steroidal anti-inflammatory drugs (NSAIDs), such as enantiomers of ibuprofen, ketoprofen, and naproxen. PMID: 25720499 [PubMed - ...
Source: Chemical Communications - February 27, 2015 Category: Chemistry Authors: Akdeniz A, Mosca L, Minami T, Anzenbacher P Tags: Chem Commun (Camb) Source Type: research

Cocrystallization induced by compressed CO2 as antisolvent: Simulation of a batch process for the estimation of nucleation and growth parameters
Publication date: March 2015 Source:The Journal of Supercritical Fluids, Volume 98 Author(s): A. Erriguible , C. Neurohr , A.-L. Revelli , S. Laugier , G. Fevotte , P. Subra-Paternault A mathematical model describing the GAS antisolvent process applied to cocrystal formation has been developed with the aim of estimating nucleation and growth parameters that are critical issues in crystallization in general. The estimates are obtained by fitting the particle sizes distribution predicted by the model to experimental data. The investigated system was naproxen+nicotinamide that assembled as cocrystals when recrystallized by ...
Source: The Journal of Supercritical Fluids - February 27, 2015 Category: Chemistry Source Type: research

Solubility of naproxen in 2-propanol+water mixtures at various temperatures
Publication date: June 2015 Source:Journal of Molecular Liquids, Volume 206 Author(s): Mahdis Mohammadzade , Mohammad Barzegar-Jalali , Abolghasem Jouyban The experimental solubility of naproxen in 2-propanol+water mixtures at different temperatures (298.2, 303.2, 308.2 and 313.2K) was reported. The solubility was correlated and/or predicted using three numerical methods; i.e., the combined van't Hoff equation and Jouyban–Acree model (method I), the extended version of the Jouyban–Acree model with Abraham parameters (method II), and the minimum number of data points (N=10) were used to train the combined model. The a...
Source: Journal of Molecular Liquids - February 26, 2015 Category: Molecular Biology Source Type: research

Sustained‐release of naproxen sodium from electrospun‐aligned PLLA–PCL scaffolds
Abstract Spontaneous tendon healing may result in reduced tissue functionality. In view of this, tissue engineering (TE) emerges as a promising approach in promoting proper tendon regeneration. However, unfavourable post‐surgical adhesion formations restrict adequate tendon healing through the TE approach. Naproxen sodium (NPS), a non‐steroidal anti‐inflammatory drug (NSAID), has been demonstrated to prevent adhesions by inhibiting the inflammatory response. Therefore, in this study, various factors, such as polymer composition, i.e. different poly‐l‐lactic acid (PLLA):polycaprolactone (PCL) ratios, and percentag...
Source: Journal of Tissue Engineering and Regenerative Medicine - February 25, 2015 Category: Molecular Biology Authors: Yuan Siang Lui, Mark P. Lewis, Say Chye Joachim Loo Tags: Research Article Source Type: research

Exposure to non-steroid anti-inflammatory drugs (NSAIDs) and suppressing hydrogen sulfide synthesis leads to altered structure and impaired function of the oesophagus and oesophagogastric junction
Conclusions Inhibition of endogenous H2S synthesis provides a novel experimental model that can be useful in preclinical studies NSAID-related non-reflux oesophagitis. H2S contributes significantly to mucosal defence in the oesophagus. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 25, 2015 Category: Drugs & Pharmacology Source Type: research

Pharmacologic Modulation of Hand Pain in Osteoarthritis: A Double‐Blind Placebo‐Controlled Functional Magnetic Resonance Imaging Study Using Naproxen
ConclusionThis study demonstrates the sensitivity of fMRI to detect the mechanisms underlying treatments of known efficacy. The data illustrate the enticing potential of fMRI as an adjunct to self‐report for detecting early signals of efficacy of novel therapies, both pharmacologic and nonpharmacologic, in small numbers of individuals with persistent pain. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 25, 2015 Category: Rheumatology Authors: Duncan Sanders, Kristina Krause, Jonathan O'Muircheartaigh, Michael A. Thacker, John P. Huggins, William Vennart, Nathalie J. Massat, Ernest Choy, Steven C. R. Williams, Matthew A. Howard Tags: Osteoarthritis Source Type: research

Risk of ischemic stroke associated with non‐steroidal anti‐inflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients with a high background CV risk. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - February 24, 2015 Category: Hematology Authors: P. García‐Poza, F. J. Abajo, M. J. Gil, A. Chacón, V. Bryant, L. A. García‐Rodríguez Tags: Original Article Source Type: research

Evaluation of the diuretic activity in two Mexican medicinal species: Selaginella nothohybrida and Selaginella lepidophylla and its effects with ciclooxigenases inhibitors
Conclusions Selaginella nothohybrida presents a moderate diuretic effect, which appears to be in partly mediated by the presence of biflavonoids and trehalose. Renal prostaglandins may be involved in the mechanism of diuresis. The present results provide a quantitative basis explaining the traditional folk medicine use of Selaginella nothohybrida as a diuretic agent by Mexican population. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 21, 2015 Category: Drugs & Pharmacology Source Type: research

The nitric oxide donor cis-[Ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice – Involvement of the soluble guanylate cyclase/KATP pathway
Publication date: Available online 10 February 2015 Source:Nitric Oxide Author(s): Ana Paula M. Santana , Bruno M. Tavares , Larisse T. Lucetti , Florêncio S. Gouveia Jr. , Ronaldo A. Ribeiro , Pedro M.G. Soares , Eduardo H.S. Sousa , Luiz G.F. Lopes , Jand-Venes R. Medeiros , Marcellus H.L.P. Souza Here, we have evaluated the protective effect of the NO donor cis-[Ru(bpy)2(SO3)NO](PF6) (FOR0810) in experimental models of gastric damage induced by naproxen or ethanol in mice, and the involvement of soluble guanylate cyclase (sGC) and ATP-sensitive K+ channels (KATP) in these events. Swiss mice were pre-treated with sali...
Source: Nitric Oxide - February 16, 2015 Category: Chemistry Source Type: research

Removal of acetaminophen and naproxen by combined coagulation and adsorption using biochar: influence of combined sewer overflow components.
Abstract The combined coagulation and adsorption of targeted acetaminophen and naproxen using activated biochar and aluminum sulfate were studied under various synthetic "combined sewer overflow" (CSO) conditions. The biochar demonstrated better adsorption performance for both acetaminophen and naproxen (removal, 94.1 and 97.7 %, respectively) than that of commercially available powdered activated carbon (removal, 81.6 and 94.1 %, respectively) due to superior carbonaceous structure and surface properties examined by nuclear magnetic resonance analysis. The adsorption of naproxen was more favorable, occupying act...
Source: Environmental Science and Pollution Research International - February 15, 2015 Category: Environmental Health Authors: Jung C, Oh J, Yoon Y Tags: Environ Sci Pollut Res Int Source Type: research

The nitric oxide donor cis-[ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice- involvement of the soluble guanylate cyclase /KATP pathway
Publication date: Available online 10 February 2015 Source:Nitric Oxide Author(s): Ana Paula M. Santana , Bruno M. Tavares , Larisse T. Lucetti , Florêncio S. Gouveia , Ronaldo A. Ribeiro , Pedro M.G. Soares , Eduardo H.S. Sousa , Luiz G.F. Lopes , Jand-Venes R. Medeiros , Marcellus H.L.P. Souza Here, we have evaluated the protective effect of the NO donor cis-[Ru(bpy)2(SO3)NO](PF6) (FOR0810) in experimental models of gastric damage induced by naproxen or ethanol in mice, and the involvement of soluble guanylate cyclase (sGC) and ATP-sensitive K+ channels (KATP) in these events. Swiss mice were pre-treated with saline, ...
Source: Nitric Oxide - February 11, 2015 Category: Chemistry Source Type: research

Non-Steroidal Anti-Inflammatory Drugs as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Treatment Effect
Conclusion Current preliminary evidence suggests no beneficial effect of NSAIDs on cognition or overall AD severity. Thus, although more research is needed in the field, the evidence available does not support the use of NSAIDs for AD treatment. (Source: Drugs and Aging)
Source: Drugs and Aging - February 3, 2015 Category: Geriatrics Source Type: research

The Value of Pharmacogenetic Testing—Reply
In Reply We thank Dr Pocinki for sharing his experience with pharmacogenetic testing over the past year. He notes that “with the exception of specific warfarin testing,” pharmacogenetic testing in his patient population has improved clinical decision making and patient outcomes. He cites his experience treating a young woman with chronic pain and “NSAID [nonsteroidal anti-inflammatory drug] intolerance” in whom pharmacogenetic testing showed to be a poor metabolizer of almost all NSAIDs, but suggested she could be treated with naproxen, which is metabolized by a different pathway. Dr Pocinki concludes that “waiti...
Source: JAMA Internal Medicine - February 1, 2015 Category: Internal Medicine Source Type: research

Removal of carbamazepine and naproxen by immobilized Phanerochaete chrysosporium under non-sterile condition.
This study explored the utilization of a white-rot fungus (WRF), Phanerochaete chrysosporium, immobilized in wood chips, to remove carbamazepine and naproxen under non-sterile condition. The removal efficiencies for both pharmaceutically active compounds (PhACs) in artificially contaminated water were improved by 4% for naproxen and 30% for carbamazepine in seven days, compared to without wood chips. Although adsorption was crucial at the early stage, bioremoval was found to be the main removal mechanism for both PhACs. The extracellular enzymes played important roles in the naproxen removal, while the intracellular enzyme...
Source: New Biotechnology - January 27, 2015 Category: Biotechnology Authors: Li X, Toledo RA, Wang S, Shim H Tags: N Biotechnol Source Type: research