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Maternal T-Cell Engraftment Interferes With Human Leukocyte Antigen Typing in Severe Combined Immunodeficiency.
CONCLUSIONS: Maternal T-cell engraftment may interfere with HLA typing in patients with SCID. Selection of the appropriate typing methods and specimens is critical for accurate HLA typing and immunologic assessment before allogeneic hematopoietic stem cell transplantation. PMID: 26834123 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 1, 2016 Category: Pathology Authors: Liu C, Duffy B, Bednarski JJ, Calhoun C, Lay L, Rundblad B, Payton JE, Mohanakumar T Tags: Am J Clin Pathol Source Type: research

MYC Immunohistochemistry to Identify MYC-Driven B-Cell Lymphomas in Clinical Practice.
CONCLUSIONS: Under optimal conditions, clinically reported MYC IHC scores are concordant with expert scores within 15%. MYC IHC does not capture all B-cell lymphomas with MYC rearrangements, however. MYC IHC and MYC fluorescence in situ hybridization are both recommended to identify MYC-driven B-cell lymphomas. PMID: 26834124 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 1, 2016 Category: Pathology Authors: Kluk MJ, Ho C, Yu H, Chen BJ, Neuberg DS, Dal Cin P, Woda BA, Pinkus GS, Rodig SJ Tags: Am J Clin Pathol Source Type: research

Oligoclonal Bands of Immunoglobulins in Serum Leading to Diagnosis of Human Immunodeficiency Virus 1 Infection.
CONCLUSIONS: The etiology of HIV-associated clonal immunoglobulin bands is hypothesized to result from chronic antigenic stimulation leading to B-cell hyperplasia. In this regard, hypergammaglobulinemia is a well-known consequence of HIV infection due to B-cell activation, associated with paraproteins, and can be seen at any stage of the disease. PMID: 26834125 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 1, 2016 Category: Pathology Authors: Soong J, Riley R, Mcpherson R Tags: Am J Clin Pathol Source Type: research

Automated Nucleated RBC Measurement Using the Sysmex XE-5000 Hematology Analyzer: Frequency and Clinical Significance of the Nucleated RBCs.
CONCLUSIONS: The automated method offers many advantages for high-throughput laboratories, including faster turnaround time, labor savings, and high reliability. Automated nRBC measurement allowed us to recognize a group of individuals who have low-level circulating nRBCs with otherwise normal CBC parameters. Nucleated RBC levels below 1.5% as detected by the automated count may be present in patients without increased erythropoiesis or a pathologic bone marrow process. PMID: 26834126 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 1, 2016 Category: Pathology Authors: Hwang DH, Dorfman DM, Hwang DG, Senna P, Pozdnyakova O Tags: Am J Clin Pathol Source Type: research

Extranodal Rosai-Dorfman Disease: Clinicopathologic Series of 10 Patients With Radiologic Correlation and Review of the Literature.
CONCLUSIONS: Extranodal RDD is rare and its manifestations varied. It may constitute a clinical and pathologic diagnostic challenge. Clinical suspicion and recognition of its histologic features are necessary for correct diagnosis and avoiding unnecessary treatment. Resection is curative in most cases. PMID: 26803323 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2016 Category: Pathology Authors: Mantilla JG, Goldberg-Stein S, Wang Y Tags: Am J Clin Pathol Source Type: research

Harmonizing the International Normalized Ratio (INR) : Standardization of Methods and Use of Novel Strategies to Reduce Interlaboratory Variation and Bias.
CONCLUSIONS: Results infer significant improvement in local patient management, with positive implications for other laboratories. For the United States in particular, lack of US Food and Drug Administration-cleared certified plasmas may compromise INR accuracy, and our novel approach may provide a workable alternative for laboratories and networks. PMID: 26800763 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 22, 2016 Category: Pathology Authors: Favaloro EJ, McVicker W, Lay M, Ahuja M, Zhang Y, Hamdam S, Hocker N Tags: Am J Clin Pathol Source Type: research

Detection of an Abnormal Myeloid Clone by Flow Cytometry in Familial Platelet Disorder With Propensity to Myeloid Malignancy.
CONCLUSIONS: The acquisition of new phenotypic aberrancies in myeloblasts as detected by flow cytometry immunophenotypic studies might be a harbinger of impending myelodysplastic syndrome or acute myeloid leukemia in a patient with familial platelet disorder with propensity to myeloid malignancy. PMID: 26800764 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 22, 2016 Category: Pathology Authors: Ok CY, Leventaki V, Wang SA, Dinardo C, Medeiros LJ, Konoplev S Tags: Am J Clin Pathol Source Type: research

Disseminated Acanthamoeba Infection Presenting With Cutaneous Lesions in an Immunocompromised Patient: A Case Report, Review of Histomorphologic Findings, and Potential Diagnostic Pitfalls.
CONCLUSIONS: Cutaneous lesions from acanthamoebiasis are exceptionally rare but should be included in the differential diagnosis of necrotic cutaneous lesions in immunocompromised patients. Although infrequently encountered, pathologists need to be aware of the morphologic features of free-living amoebas. Immunohistochemical and molecular studies can confirm the diagnosis. Multiagent treatment regimens, when initiated empirically, have been more successful than single-agent regimens, but infections involving the central nervous system are almost universally fatal. PMID: 26800765 [PubMed - as supplied by publisher] (Sou...
Source: American Journal of Clinical Pathology - January 22, 2016 Category: Pathology Authors: Morrison AO, Morris R, Shannon A, Lauer SR, Guarner J, Kraft CS Tags: Am J Clin Pathol Source Type: research

Unique Renal Manifestation of Type I Cryoglobulinemia, With Massive Crystalloid Deposits in Glomerular Histiocytes, Podocytes, and Endothelial Cells.
CONCLUSIONS: This patient displays a unique renal manifestation of type I cryoglobulinemia related to a plasma cell dyscrasia. PMID: 26796493 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 21, 2016 Category: Pathology Authors: Hoelbeek J, Duivenvoorden R, de Boer OJ, Claessen N, Van den Bergh Weerman MA, Roelofs JJ, Kers J, Ten Berge IJ, Florquin S Tags: Am J Clin Pathol Source Type: research

Pathologic Staging and Survival of Patients With Synchronous Bilateral Lung Carcinomas.
CONCLUSIONS: Patients with resected synchronous bilateral lung cancers had similar 10-year OS to patients with stage I disease, regardless of CHE data. Most resected tumors were synchronous primaries by CHE. PMID: 26796494 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 21, 2016 Category: Pathology Authors: Walts AE, Mirocha JM, Leong T, Marchevsky AM Tags: Am J Clin Pathol Source Type: research

LMO2 Is a Specific Marker of T-Lymphoblastic Leukemia/Lymphoma.
CONCLUSIONS: LMO2 is therefore a useful marker for immunophenotypic assessment of thymic neoplasms. PMID: 26796495 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 21, 2016 Category: Pathology Authors: Jevremovic D, Roden AC, Ketterling RP, Kurtin PJ, McPhail ED Tags: Am J Clin Pathol Source Type: research

Acute Cellular Rejection and C4d Positivity in Heart Transplantation : A Manifestation of Asymptomatic Antibody-Mediated Rejection?
CONCLUSIONS: Our result indicate that C4d and ACR positivity in posttransplant patients may be a harbinger of a subclinical form of asymptomatic AMR. PMID: 26767383 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 14, 2016 Category: Pathology Authors: Mohamedali B, Pyle J, Bhat G Tags: Am J Clin Pathol Source Type: research

Global Cancer Care:  The Role of Pathology.
PMID: 26712865 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Wilson ML, Fleming KA Tags: Am J Clin Pathol Source Type: research

Endometrial Carcinoma:  Role of Current and Emerging Biomarkers in Resolving Persistent Clinical Dilemmas.
CONCLUSIONS: Clinical trials are leading the charge for substantial gains toward personalized treatment of aggressive endometrial carcinoma subtypes. PMID: 26712866 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Buhtoiarova TN, Brenner CA, Singh M Tags: Am J Clin Pathol Source Type: research

Practical Utility and Accuracy of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Corynebacterium Species and Other Medically Relevant Coryneform-Like Bacteria.
CONCLUSIONS: Rapid on-plate testing yielded identification of more Corynebacterium species and related bacteria than biochemical methods. PMID: 26712867 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Suwantarat N, Weik C, Romagnoli M, Ellis BC, Kwiatkowski N, Carroll KC Tags: Am J Clin Pathol Source Type: research

Immunohistochemical Detection of NRASQ61R Mutation in Diverse Tumor Types.
CONCLUSIONS: Our studies confirmed that immunohistochemistry provides excellent sensitivity and specificity for detecting the NRASQ61R mutation in a variety of tumor types in a clinical setting. PMID: 26712868 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Dias-Santagata D, Su Y, Hoang MP Tags: Am J Clin Pathol Source Type: research

Use of Cytology, E6/E7 mRNA, and p16INK4a-Ki-67 to Define the Management of Human Papillomavirus (HPV)-Positive Women in Cervical Cancer Screening.
CONCLUSIONS: The high sensitivity of combined strategies probably allows longer intervals in HPV-positive, triage-negative women. PMID: 26712869 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Gustinucci D, Giorgi Rossi P, Cesarini E, Broccolini M, Bulletti S, Carlani A, D'angelo V, D'amico MR, Di Dato E, Galeazzi P, Malaspina M, Martinelli N, Spita N, Tintori B, Giaimo MD, Passamonti B Tags: Am J Clin Pathol Source Type: research

Extranodal Natural Killer/T-Cell Lymphoma in Children and Adolescents:  A Report of 17 Cases in China.
CONCLUSIONS: ENKTL not preceded by another EBV-related disorder in children and adolescents is occasionally observed in China. It tends to have a male predominance. The upper aerodigestive tract, especially the sinonasal region, is the most commonly involved site. The morphologic features and immunophenotype in children and adolescents are similar to that occurring in adults. PMID: 26712870 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Huang Y, Xie J, Ding Y, Zhou X Tags: Am J Clin Pathol Source Type: research

FGFR1 Amplification in Squamous Cell Carcinoma of the Lung with Correlation of Primary and Metastatic Tumor Status.
CONCLUSIONS: Frequency of FGFR1 amplification is similar in SqCC with and without lymph node metastases, but status in metastatic sites may be discordant from the primary in a small subset of cases, which may affect the decision to perform testing of metastatic SqCCs. PMID: 26712871 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Monaco SE, Rodriguez EF, Mahaffey AL, Dacic S Tags: Am J Clin Pathol Source Type: research

Correlation of Circulating Complement-Fixing Donor-Specific Antibodies Identified by the C1q Assay and Presence of C4d in Endomyocardial Biopsy Specimens.
CONCLUSIONS: In this cohort of 44 patients, no significant correlation was observed between circulating C1q DSAs and C4d IF in EMB specimens. Additional studies are needed to further evaluate the association of C1q DSAs with EMB specimens and C4d staining. PMID: 26712872 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Frank R, Lal P, Kearns J, Molina MR, Wald JW, Goldberg LR, Kamoun M Tags: Am J Clin Pathol Source Type: research

Reflex Repeat HER2 Testing of Grade 3 Breast Carcinoma at Excision Using Immunohistochemistry and In Situ Analysis:  Frequency of HER2 Discordance and Utility of Core Needle Biopsy Parameters to Refine Case Selection.
CONCLUSIONS: Our series demonstrated a high concordance rate (97%) for HER2 at excision in grade 3 breast tumors with a negative core biopsy result. These findings suggest that reflex repeat HER2 testing of all these cases, which has significant cost and workload implications, may not be justified. Features that may indicate HER2 heterogeneity, such as equivocal IHC on CNB specimens or tumor upgrade at excision, may help refine selection of cases for repeat testing. PMID: 26712873 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Prendeville S, Feeley L, Bennett MW, O'Connell F, Browne TJ Tags: Am J Clin Pathol Source Type: research

Detection of Acetylcholine Receptor Blocking Antibodies by Flow Cytometry.
CONCLUSIONS: Our results indicate that a new immunofluorescent flow cytometric AChR blocking antibody assay is not only feasible but clinically comparable in both sensitivity (91%) and specificity (99%) compared with radioassay. PMID: 26712874 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Cromar A, Lozier BK, Haven TR, Hill HR Tags: Am J Clin Pathol Source Type: research

Triploidy:  Variation of Phenotype.
CONCLUSIONS: The presence of major malformations and growth restriction during pregnancy makes triploidy a potential diagnosis. There are no obligate clinical features in triploidy. Syndactyly, especially 3-4 syndactyly of the hands, is a distinctive feature. Cystic changes in the placenta can be seen by ultrasound during pregnancy. There was no difference in the phenotype between triploid infants associated with partial moles and those with nonmolar placentas. PMID: 26712875 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Toufaily MH, Roberts DJ, Westgate MN, Holmes LB Tags: Am J Clin Pathol Source Type: research

Absence or Presence of High-Grade Squamous Intraepithelial Lesion in Cervical Conization Specimens:  A Clinicopathologic Study of 540 Cases.
CONCLUSIONS: We advocate careful review of all excision-triggering biopsy and cytology, especially in cases of LSIL-H. Patients with negative cones should be surveyed with cytology and HR-HPV testing. PMID: 26712876 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Walavalkar V, Stockl T, Owens CL, Manning M, Papa D, Li A, Khan A, Liu Y Tags: Am J Clin Pathol Source Type: research

A Minimum Volume of More Than 60 mL Is Necessary for Adequate Cytologic Diagnosis of Malignant Pericardial Effusions.
CONCLUSIONS: Small-volume pericardiocentesis specimens detect fewer malignancies and have inferior sensitivity compared with pericardial biopsy. A volume of more than 60 mL should be submitted to cytology to ensure adequate diagnosis of pericardial fluids. PMID: 26712877 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Rooper LM, Ali SZ, Olson MT Tags: Am J Clin Pathol Source Type: research

Diagnostic Utility of Flow Cytometry Analysis of Reactive T Cells in Nodular Lymphocyte-Predominant Hodgkin Lymphoma.
CONCLUSIONS: Increased portions of CD57 + T cells and CD4 + CD8 + T cells are highly suggestive of the possibility of NLPHL. In addition, NLPHL diagnosis appears unlikely if neither CD57 + T cells nor CD4 + CD8 + T cells are increased. Future prospective studies including cases of progressive transformation of germinal center and T-cell/histiocyte-rich large B-cell lymphoma will further define the utility of flow cytometry of T cells in NLPHL. PMID: 26712878 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: David JA, Huang JZ Tags: Am J Clin Pathol Source Type: research

Clonality Analysis of Immunoglobulin Gene Rearrangement by Next-Generation Sequencing in Endemic Burkitt Lymphoma Suggests Antigen Drive Activation of BCR as Opposed to Sporadic Burkitt Lymphoma.
CONCLUSIONS: These findings support the view that the antigenic pressure plays a key role in the pathogenetic pathways of eBL, which may be partially distinct from those driving sBL development. PMID: 26712879 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Amato T, Abate F, Piccaluga P, Iacono M, Fallerini C, Renieri A, De Falco G, Ambrosio MR, Mourmouras V, Ogwang M, Calbi V, Rabadan R, Hummel M, Pileri S, Leoncini L, Bellan C Tags: Am J Clin Pathol Source Type: research

Frequency of Pancreatic Hyperamylasemia in Human Immunodeficiency Virus-Positive Patients in the Highly Active Antiretroviral Therapy Era.
CONCLUSIONS: In our study, both HIV+ and HIV+Tx+ do not show an increased frequency of P-AMY elevation. Frank pancreatic disease is rare in this clinical setting. PMID: 26712880 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Szőke D, Ridolfo A, Valente C, Galli M, Panteghini M Tags: Am J Clin Pathol Source Type: research

Matrix Metalloproteinase 3 Gene Polymorphism and Its Level Predict Morbidity After Acute Myocardial Infarction.
CONCLUSIONS: MMP-3 polymorphism has a significant association with the risk of developing morbidity after AMI. Higher predischarge MMP-3 levels are associated with left ventricular dysfunction after AMI. PMID: 26712881 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: El-Aziz TA, Mohamed RH Tags: Am J Clin Pathol Source Type: research

Nakhleh RG, Ed. Error Reduction and Prevention in Surgical Pathology.
PMID: 26712882 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Schmidt RL, Cohen MB Tags: Am J Clin Pathol Source Type: research

Laboratory Critical Values Should Support Effective Clinical Decision Making.
PMID: 26712883 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Authors: Piva E, Plebani M, Doering TA, Crawford JM, Plapp F Tags: Am J Clin Pathol Source Type: research

About the Journal.
Authors: PMID: 26712884 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Tags: Am J Clin Pathol Source Type: research

AJCP American Journal of Clinical Pathology January 2016 Volume 145 Number 1 - Front Cover.
Authors: PMID: 26712885 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Editorial Board.
Authors: PMID: 26712886 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Table of Contents.
Authors: PMID: 26712887 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 1, 2016 Category: Pathology Tags: Am J Clin Pathol Source Type: research

The Impact of Implementation of Rapid QuickFISH Testing for Detection of Coagulase-Negative Staphylococci at a Community-Based Hospital.
CONCLUSIONS: The QuickFISH assay, with its ability to provide timely and actionable results nearly simultaneously with the Gram stain, in conjunction with an effective antimicrobial stewardship program, has been adopted as standard of care at our community-based hospital. PMID: 26657205 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 10, 2015 Category: Pathology Authors: Koncelik DL, Hernandez J Tags: Am J Clin Pathol Source Type: research

Pathologists and Liability: An Old Medical Story Needing a New Ending.
PMID: 26572987 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Allen TC, Liang BA Tags: Am J Clin Pathol Source Type: research

Pathology Consultation on Human Chorionic Gonadotropin Testing for Pregnancy Assessment.
CONCLUSIONS: hCG assays are reliable diagnostic tests for pregnancy assessment, but a clear understanding of their limitations is necessary for appropriate result interpretation. PMID: 26572988 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Greene DN, Grenache DG, Education Committee of the Academy of Clinical Laboratory Physicians and Scientist Tags: Am J Clin Pathol Source Type: research

The LAST Guidelines in Clinical Practice: Implementing Recommendations for p16 Use.
CONCLUSIONS: Implementation of the p16 LAST guidelines resulted in a significant increase in p16 use and a significant increase in the positive predictive value of p16+ HSIL. PMID: 26572990 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Clinton LK, Miyazaki K, Ayabe A, Davis J, Tauchi-Nishi P, Shimizu D Tags: Am J Clin Pathol Source Type: research

Fine-Needle Aspiration Diagnoses of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma.
CONCLUSIONS: If NFVPTCs were no longer termed carcinomas, this would affect the rate of malignancy of FNA diagnostic categories. Cytologic and molecular features could aid in identifying NFVPTCs at the time of FNA diagnosis. PMID: 26572991 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Howitt BE, Chang S, Eszlinger M, Paschke R, Drage MG, Krane JF, Barletta JA Tags: Am J Clin Pathol Source Type: research

Evaluation of Paroxysmal Nocturnal Hemoglobinuria Screening by Flow Cytometry Through Multicentric Interlaboratory Comparison in Four Countries.
CONCLUSIONS: We succeeded in rallying numerous French-speaking clinical laboratories for both surveys and in harmonizing the technical practice by highlighting common pitfalls. PMID: 26572992 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Debliquis A, Wagner-Ballon O, Le Garff-Tavernier M, Fossat C, Chatelain B, Letestu R, Drénou B, HPN-AFC Group Tags: Am J Clin Pathol Source Type: research

The Minimal Carcinoma Triple Stain Is Superior to Commercially Available Multiplex Immunohistochemical Stains: Breast Triple Stain and LC/DC Breast Cocktail.
CONCLUSIONS: When technically sufficient, all three immunostains demonstrated relative strengths and weaknesses in their ability to provide diagnostic information with the highest consistency and ease of use. Many cases stained with LCDC were technically insufficient due to a suboptimal staining protocol provided by the company. Overall, the MC Triple Stain outperformed BTS and LCDC by more consistently providing more diagnostic information. The MC Triple Stain is a viable alternative to other multiplex immunostains in evaluating small foci of carcinoma, particularly when both the histologic type and extent of disease (in ...
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Ginter PS, Varma S, Liu YF, Shin SJ Tags: Am J Clin Pathol Source Type: research

Utility of Direct Immunofluorescence Testing for IgA in Patients With High and Low Clinical Suspicion for Dermatitis Herpetiformis.
CONCLUSIONS: It is anticipated that the NPV and PPV will vary due to differing clinical practice characteristics; however, in patients with a low clinical suspicion for DH, these data argue that it may be reasonable to first perform a biopsy for routine histologic evaluation before requesting DIF analysis. PMID: 26572994 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Bresler SC, Granter SR Tags: Am J Clin Pathol Source Type: research

Drop-to-Drop Variation in the Cellular Components of Fingerprick Blood: Implications for Point-of-Care Diagnostic Development.
CONCLUSIONS: These data suggest caution when using measurements from a single drop of fingerprick blood. PMID: 26572995 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Bond MM, Richards-Kortum RR Tags: Am J Clin Pathol Source Type: research

The Clinical Laboratory Service: Medical Practitioners' Satisfaction in Southern Ethiopia.
CONCLUSIONS: This study identified wide room for improvement by the services provided from clinical laboratories. Corrective actions for the less satisfied service categories and continuous monitoring of laboratory activities are essential for the development of quality in clinical laboratories of health institutions in southern Ethiopia. PMID: 26572996 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Mengesha MB Tags: Am J Clin Pathol Source Type: research

Accuracy and Interobserver Variability of the Cytologic Diagnosis of Low-Grade Urothelial Carcinoma in Instrumented Urinary Tract Cytology Specimens.
CONCLUSIONS: We found that UTCy has a low sensitivity but relatively high specificity, resulting in poor to fair accuracy for the diagnosis of LGUC; the level of agreement between reviewers was only fair to moderate. PMID: 26572997 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: McCroskey Z, Pambuccian SE, Kleitherms S, Antic T, Cohen MB, Barkan GA, Wojcik EM Tags: Am J Clin Pathol Source Type: research

Development of a BK Virus Real-Time Quantitative Assay Using the bioMérieux Analyte-Specific Reagents in Plasma Specimens.
CONCLUSIONS: The laboratory-developed test with bioMérieux BKV reagents is a reliable and sensitive assay for BKV DNA quantitation compared with the Qiagen ASR test. PMID: 26572998 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Rennert H, Fernandes H, Gilani Z, Sipley J Tags: Am J Clin Pathol Source Type: research

Dual Use of E-Cadherin and D2-40 Immunostaining in Unusual Meningioma Subtypes.
CONCLUSIONS: Dual E-cadherin/D2-40 IHC can supplement diagnosis of meningioma. PMID: 26573000 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Mrachek EK, Davis D, Kleinschmidt-DeMasters BK Tags: Am J Clin Pathol Source Type: research

High Levels of Regulatory T Cells in Blood Are a Poor Prognostic Factor in Patients With Diffuse Large B-Cell Lymphoma.
CONCLUSIONS: Changes in blood immune cells occur in patients with DLBCL. The results also support a suppressive role of Tregs in adaptive immunity and correlate with poor-risk prognostic factors. PMID: 26573001 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Chang C, Wu SY, Kang YW, Lin KP, Chen TY, Medeiros LJ, Chang KC Tags: Am J Clin Pathol Source Type: research

The Spectrum of Histopathologic Findings in Cutaneous Lesions in Patients With Still Disease.
CONCLUSIONS: It is important to be aware of the broad histologic spectrum that may be encountered in Still disease and to consider Still disease in the differential diagnosis of neutrophil-rich, lymphocyte-rich, and mixed inflammatory dermatoses. While the histologic findings seen in biopsy specimens of the evanescent rash are nonspecific, a distinctive variant also exists characterized by prominent epidermal apoptosis, especially involving the upper layers. PMID: 26573002 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2015 Category: Pathology Authors: Larson AR, Laga AC, Granter SR Tags: Am J Clin Pathol Source Type: research