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American Journal of Clinical Pathology

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When the rubber meets the road: dealing with a returning traveler from west Africa during the ebola outbreak of 2014.
PMID: 25239405 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Guarner J Tags: Am J Clin Pathol Source Type: research

Resident training in new technologies.
PMID: 25239406 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

IgG4+ Plasma Cells in Isolated Reactive Lymphadenopathy.
PMID: 25239407 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Cotta CV, Hsi ED Tags: Am J Clin Pathol Source Type: research

Cancer in low- and middle-income countries: where to start? Is it pathology?
PMID: 25239408 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Guarner J, Fleming K Tags: Am J Clin Pathol Source Type: research

Clinical Laboratory Immunology: An Indispensable Player in Laboratory Medicine.
CONCLUSIONS: It is anticipated that sharing this knowledge will increase awareness of the discipline of clinical laboratory immunology at the postdoctoral level with implications for the practice of laboratory medicine. PMID: 25239409 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Tebo AE, Detrick B, Hamilton RG, Khanolkar A, O'Gorman MR, Schmitz JL, Abraham RS Tags: Am J Clin Pathol Source Type: research

The current state of resident training in genomic pathology: a comprehensive analysis using the resident in-service examination.
CONCLUSIONS: The RISE is a powerful tool for assessing the state of resident training in genomic pathology and current results suggest a significant deficit. The results also provide a baseline to assess future initiatives to improve genomics education for pathology residents such as those developed by the TRIG Working Group. PMID: 25239410 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Haspel RL, Rinder HM, Frank KM, Wagner J, Ali AM, Fisher PB, Parks ER, Training Residents in Genomics (TRIG) Working Group Tags: Am J Clin Pathol Source Type: research

CD8+ Lymphocyte Intratumoral Infiltration as a Stage-Independent Predictor of Merkel Cell Carcinoma Survival: A Population-Based Study.
CONCLUSIONS: This study of prospectively captured MCC cases supports the concept that cellular immunity is important in MCC outcome and that CD8+ lymphocyte infiltration adds prognostic information to conventional staging. PMID: 25239411 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Paulson KG, Iyer JG, Simonson WT, Blom A, Thibodeau RM, Schmidt M, Pietromonaco S, Sokil M, Warton EM, Asgari MM, Nghiem P Tags: Am J Clin Pathol Source Type: research

Abundance of IgG4+ Plasma Cells in Isolated Reactive Lymphadenopathy Is No Indication of IgG4-Related Disease.
CONCLUSION: Without a clinical suspicion of IgG4-related disease, these morphologic patterns and high numbers of IgG4-positive plasma cells should be interpreted with care to avoid an erroneous diagnosis of IgG4-related disease. PMID: 25239412 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Martinez LL, Friedländer E, van der Laak JA, Hebeda KM Tags: Am J Clin Pathol Source Type: research

Utility of measurement of interleukin-1ß and interleukin-8 in the diagnosis of complicated parapneumonic pleural effusions.
CONCLUSIONS: Measurement of IL-1β and IL-8 in pleural fluid may be useful in the early diagnosis of CPPE, although individually, it may not improve the results obtained with the PFLD. Further studies are needed to more firmly establish what role these new parameters can play in the diagnosis of CPPE. PMID: 25239413 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: San José ME, Ferreiro L, Soneira ME, González-Barcala FJ, Vázquez MC, Golpe A, Valdés L Tags: Am J Clin Pathol Source Type: research

Comparison study of the eosin-5'-maleimide binding test, flow cytometric osmotic fragility test, and cryohemolysis test in the diagnosis of hereditary spherocytosis.
CONCLUSIONS: Our results demonstrate that both the EMA binding and FC OF tests are useful as screening tests for the diagnosis of HS, but the cryohemolysis test has limited use due to its false positivity in IDA, with the Hb/MCHC ratio the most useful parameter for assessing the clinical severity of HS. PMID: 25239414 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Park SH, Park CJ, Lee BR, Cho YU, Jang S, Kim N, Koh KN, Im HJ, Seo JJ, Park ES, Lee JW, Yoo KH, Jung HL Tags: Am J Clin Pathol Source Type: research

Nevus-associated melanomas: clinicopathologic features.
CONCLUSIONS: Nevus-associated melanomas, which represent one-third of the melanomas in southeast Brazil, are associated with intermittent sun exposure, superficial spreading melanomas, and lower Breslow thickness. This is one of the largest series describing nevus-associated melanomas in Latin America. PMID: 25239415 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Shitara D, Nascimento MM, Puig S, Yamada S, Enokihara MM, Michalany N, Bagatin E Tags: Am J Clin Pathol Source Type: research

Thromboelastography is a suboptimal test for determination of the underlying cause of bleeding associated with cardiopulmonary bypass and may not predict a hypercoagulable state.
CONCLUSIONS: TEG had limited utility in identifying the underlying cause of bleeding and was not predictive of postoperative bleeding associated with cardiac surgery compared with conventional coagulation tests. A shortened TEG R time may not represent a hypercoagulable state. PMID: 25239416 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Welsh KJ, Padilla A, Dasgupta A, Nguyen AN, Wahed A Tags: Am J Clin Pathol Source Type: research

A cross-sectional pilot study of blood utilization in 27 hospitals in northern california.
CONCLUSIONS: There is awareness of the need for transfusion oversight. However, the findings show a wide spectrum of transfusion practice, and high-yield measures, such as electronic cross-match and transfusion triggers, have not been uniformly implemented. The results indicate that there is a role for blood centers to assist client hospitals to maximize their efficiency and reduce blood utilization. PMID: 25239417 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Bloch EM, Cohn C, Bruhn R, Hirschler N, Nguyen KA Tags: Am J Clin Pathol Source Type: research

Using the Hemoglobin Content of Reticulocytes (RET-He) to Evaluate Anemia in Patients With Cancer.
CONCLUSIONS: These results support the use of RET-He in the evaluation of iron deficiency in a cancer care setting. PMID: 25239418 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Peerschke EI, Pessin MS, Maslak P Tags: Am J Clin Pathol Source Type: research

Nocardiosis in 132 patients with cancer: microbiological and clinical analyses.
CONCLUSIONS: Diverse Nocardia species can cause secondary infections in patients with cancer. Timely species identification and antimicrobial susceptibility tests may guide treatment. PMID: 25239419 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Wang HL, Seo YH, LaSala PR, Tarrand JJ, Han XY Tags: Am J Clin Pathol Source Type: research

Analysis of the Leprosy Agents Mycobacterium leprae and Mycobacterium lepromatosis in Four Countries.
CONCLUSIONS: The leprosy agents vary in geographic distribution. Finding M lepromatosis in Brazil and Myanmar suggests wide existence of this newly discovered species. The leprosy manifestations likely vary with the etiologic agents. PMID: 25239420 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Han XY, Aung FM, Choon SE, Werner B Tags: Am J Clin Pathol Source Type: research

Diagnosis of cancer in rural rwanda: early outcomes of a phased approach to implement anatomic pathology services in resource-limited settings.
CONCLUSIONS: Our experience demonstrates that anatomic pathology services can be established in resource-limited settings and local capacity can be built to support accurate diagnoses. Our approach included leveraging partnerships, volunteer experts, and task shifting and will be expanded to include telepathology. PMID: 25239422 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Mpunga T, Tapela N, Hedt-Gauthier BL, Milner D, Nshimiyimana I, Muvugabigwi G, Moore M, Shulman DS, Pepoon JR, Shulman LN Tags: Am J Clin Pathol Source Type: research

Diagnostic Immunophenotype of Acute Promyelocytic Leukemia Before and Early During Therapy With All-trans Retinoic Acid.
CONCLUSIONS: Information about recent ATRA administration is critical for adequate interpretation of the flow cytometric findings in patients with suspected APL. PMID: 25239423 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Horna P, Zhang L, Sotomayor EM, Lancet JE, Moscinski LC Tags: Am J Clin Pathol Source Type: research

Do the Flags Related to Immature Granulocytes Reported by the Sysmex XE-5000 Warrant a Microscopic Slide Review?
CONCLUSIONS: The "Imm Gran?" flag has a poor analytical quality and gives no substantial information on the presence of blasts in the sample. We therefore suggest reporting the automated IG count without initial microscopic slide review. PMID: 25239424 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Eilertsen H, Hagve TA Tags: Am J Clin Pathol Source Type: research

Comparison of the aptima and cervista tests for detection of high-risk human papillomavirus in cervical cytology specimens.
CONCLUSIONS: We found poor positive percent agreement between the results of the Aptima and Cervista HPV tests and described an important source of false-positive Cervista results. PMID: 25239425 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Nolte FS, Ribeiro-Nesbitt DG Tags: Am J Clin Pathol Source Type: research

δβ-Thalassemia Trait: How Can We Discriminate It From β-Thalassemia Trait and Iron Deficiency Anemia?
CONCLUSIONS: RDW is the best parameter to discriminate δβ-TT from β-TT. The degree of anisocytosis in patients with β-TT and δβ-TT is strongly correlated with HbF. PMID: 25239426 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Velasco-Rodríguez D, Alonso-Domínguez JM, González-Fernández FA, Villarrubia J, Ropero P, Martínez-Nieto J, de la Fuente F, Guillén R, Acedo N, Serí C, Cava F Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25239427 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Learning to be a consultant: what should be taught.
PMID: 25125615 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

An analysis of clinical consultation activities in clinical pathology: who requests help and why.
CONCLUSIONS: At our laboratory, consultation requests primarily originate from primary care physicians. Consultation requests vary by caller type. PMID: 25125616 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Schmidt RL, Panlener J, Hussong JW Tags: Am J Clin Pathol Source Type: research

Loss of blast heterogeneity in myelodysplastic syndrome and other chronic myeloid neoplasms.
CONCLUSIONS: Analysis of a limited antibody panel with a focus on CD13/HLA-DR expression provides relatively high specificity and sensitivity for the detection of myeloid neoplasms. PMID: 25125617 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Jevremovic D, Timm MM, Reichard KK, Morice WG, Hanson CA, Viswanatha DS, Howard MT, Nguyen PL Tags: Am J Clin Pathol Source Type: research

Rapid detection of the active cardiac glycoside convallatoxin of lily of the valley using Loci digoxin assay.
CONCLUSIONS: LOCI digoxin assay can be used for rapid detection of convallatoxin, and Digibind can bind convallatoxin in vitro. PMID: 25125619 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Welsh KJ, Huang RS, Actor JK, Dasgupta A Tags: Am J Clin Pathol Source Type: research

Mesothelin expression in pancreatic mucinous cysts.
CONCLUSION: Our findings suggest that MLSN can be used as a marker of neoplastic transformation of epithelial cells in pancreatic mucinous cysts. The findings can help identify neoplastic mucinous epithelium. PMID: 25125620 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Frank R, Li S, Ahmad NA, Sepulveda AR, Jhala NC Tags: Am J Clin Pathol Source Type: research

Evaluation of Napsin A, TTF-1, p63, p40, and CK5/6 Immunohistochemical Stains in Pulmonary Neuroendocrine Tumors.
CONCLUSION: Pulmonary neuroendocrine tumors have a distinct but nonspecific profile on IHC panel commonly applied to subclassify NSCLCs. They are napsin A-/p40-/p63-/CK5/6-/TTF-1±. Recognizing this profile may have value in separating neuroendocrine tumors from NSCLCs. PMID: 25125621 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Zhang C, Schmidt LA, Hatanaka K, Thomas D, Lagstein A, Myers JL Tags: Am J Clin Pathol Source Type: research

A dual-fixed neutrophil substrate improves interpretation of antineutrophil cytoplasmic antibodies by indirect immunofluorescence.
CONCLUSIONS: Concomitant staining on formalin fixation of IIF-positive ethanol-fixed ANCA samples improves the interpretation of ANCA testing and is predictive of vasculitis autoantigens MPO and PR3. PMID: 25125622 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Lin MW, Silvestrini RA, Culican S, Campbell D, Fulcher DA Tags: Am J Clin Pathol Source Type: research

Platelet mapping assay interference due to platelet activation in heparinized samples.
CONCLUSIONS: Unanticipated platelet activation/aggregation occurring in the heparinized TEGPM samples lead to erroneous percent inhibition results. PMID: 25125623 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Nelles NJ, Chandler WL Tags: Am J Clin Pathol Source Type: research

Aggressive B-Cell Lymphomas With Translocations Involving BCL6 and MYC Have Distinct Clinical-Pathologic Characteristics.
CONCLUSIONS: B-cell lymphomas with translocations involving MYC and BCL6 have morphologic and immunophenotypic features suggestive of Burkitt lymphoma or gray zone lymphoma, and they tend to be diagnosed mainly in women, often in extranodal locations. PMID: 25125624 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Turakhia SK, Hill BT, Dufresne SD, Nakashima MO, Cotta CV Tags: Am J Clin Pathol Source Type: research

Aberrations of MYC Are a Common Event in B-Cell Prolymphocytic Leukemia.
CONCLUSIONS: These results suggest that deregulation of MYC plays an important role in the pathogenesis of B-PLL and expands the spectrum of B-cell neoplasms associated with aberrations of MYC. PMID: 25125625 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Flatley E, Chen AI, Zhao X, Jaffe ES, Dunlap JB, Pittaluga S, Abdullah S, Olson SB, Spurgeon SE, Fan G Tags: Am J Clin Pathol Source Type: research

Recognition and discrimination of tissue-marking dye color by surgical pathologists: recommendations to avoid errors in margin assessment.
CONCLUSIONS: Pathologists have difficulty identifying and distinguishing certain colors of TMDs. The combined use of certain colors of TMDs (yellow/orange/red, blue/violet, and red/violet) within the same specimen should be avoided to decrease the risk of inaccurately reporting specimen margins. PMID: 25125626 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Williams AS, Hache KD Tags: Am J Clin Pathol Source Type: research

Significant histologic features differentiating cellular fibroadenoma from phyllodes tumor on core needle biopsy specimens.
CONCLUSIONS: The presence of mitoses (three or more) and/or total histologic features of three or more on CNB specimens were the most helpful features in predicting PT on excision. PMID: 25125627 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Yasir S, Gamez R, Jenkins S, Visscher DW, Nassar A Tags: Am J Clin Pathol Source Type: research

Utility of immunofluorescence testing for vascular IgA in adult patients with leukocytoclastic vasculitis.
CONCLUSIONS: Our data confirm that vascular IgA is nonspecific and also demonstrate that the utility of IF studies for vasculitis is influenced by the clinical presentation and the clinician's level of suspicion for HSP. Our data show that the clinical features and the overall clinical impression are helpful in selecting which patients are most likely to benefit from IF testing. PMID: 25125628 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Larson AR, Granter SR Tags: Am J Clin Pathol Source Type: research

Performance Characteristics of Nested Polymerase Chain Reaction vs Real-Time Polymerase Chain Reaction Methods for Detecting Mycobacterium tuberculosis Complex in Paraffin-Embedded Human Tissues.
CONCLUSIONS: Well-designed RT-PCR and N-PCR can effectively identify MTB in FFPE specimens. PMID: 25125630 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Seo AN, Park HJ, Lee HS, Park JO, Chang HE, Nam KH, Choe G, Park KU Tags: Am J Clin Pathol Source Type: research

Correlation between biological marker expression and fluorine-18 fluorodeoxyglucose uptake in hepatocellular carcinoma.
CONCLUSIONS: Our study indicates that FDG uptake is associated with the expression of pSTAT3, HIF1α, and GLUT1 in hepatocellular carcinoma. The expression of these proteins shows a correlation with poor differentiation and vascular invasion. PMID: 25125631 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Mano Y, Aishima S, Kubo Y, Tanaka Y, Motomura T, Toshima T, Shirabe K, Baba S, Maehara Y, Oda Y Tags: Am J Clin Pathol Source Type: research

Utility of nine-color, 11-parameter flow cytometry for detection of plasma cell neoplasms: a comparison with bone marrow morphologic findings and concurrent m-protein studies in serum and urine.
CONCLUSIONS: The nine-color analytic cocktail eliminates duplication of PC gating reagents required for evaluation of the same epitopes using a five- or six-color approach. Fewer analytic cocktails result in lower instrument acquisition times per case, a significant factor for the large data sets required for optimal residual disease assessment. Finally, concurrent analysis of nine epitopes and two light scatter parameters aids detection of residual disease, particularly when it is mixed with polyclonal PCs. PMID: 25125632 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Behdad A, Ross CW, Jacques J, Kota U, Keren D, Stoolman L Tags: Am J Clin Pathol Source Type: research

Value-based flow testing of chronic lymphoproliferative disorders: a quality improvement project to develop an algorithm to streamline testing and reduce costs.
CONCLUSIONS: We project this approach will result in a 40% decrease in antibody utilization. PMID: 25125633 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Oberley MJ, Fitzgerald S, Yang DT, Morgan A, Johnson J, Leith C Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25125634 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Clinical laboratory directors.
PMID: 25015851 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

Large B-Cell Lymphoma Rich in PD-1+ T Cells: An Overlooked Subtype of Diffuse Large B-Cell Lymphoma?
PMID: 25015852 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Hartmann S, Hansmann ML Tags: Am J Clin Pathol Source Type: research

The practice of clinical pathology: a quantitative description of laboratory director activities at a large academic medical center.
CONCLUSIONS: Although the activities of clinical laboratory directors have been described elsewhere, this is the first study detailing the effort allocated to these various activities in quantitative terms. The study demonstrated that less than 20% of an academic laboratory director's effort involves administrative activities that could potentially be performed by a professional manager lacking doctorate level medical or scientific expertise. PMID: 25015853 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Branda JA, Dighe AS, Dzik W, Ferraro MJ, Flood J, Lee-Lewandrowski E, Makar R, Mandokolathur M, Rosenberg ES, Saidman S, Sluss P, Sohani AR, Stowell C, Van Cott EM, Lewandrowski KB Tags: Am J Clin Pathol Source Type: research

Large B-Cell Lymphomas Poor in B Cells and Rich in PD-1+ T Cells Can Mimic T-Cell Lymphomas.
CONCLUSIONS: Large B-cell lymphomas poor in B cells and rich in T cells can have diffuse sheets of reactive PD-1+ T cells, some with atypical morphologic and immunophenotypic features mimicking a T-cell lymphoma. Careful assessment of the immunoarchitecture and background inflammatory and stromal cells can prevent erroneous diagnoses in such cases. PMID: 25015854 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Ohgami RS, Zhao S, Natkunam Y Tags: Am J Clin Pathol Source Type: research

Reduced glucocorticoid receptor expression predicts bladder tumor recurrence and progression.
CONCLUSIONS: GR expression was downregulated in bladder tumors compared with nonneoplastic bladder tumors and in high-grade/MI tumors compared with low-grade/NMI tumors. Decreased expression of GR, as an independent prognosticator, predicted recurrence of NMI tumors. These results support experimental evidence suggesting an inhibitory role of GR signals in bladder cancer outgrowth. PMID: 25015855 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Ishiguro H, Kawahara T, Zheng Y, Netto GJ, Miyamoto H Tags: Am J Clin Pathol Source Type: research

Severity of rhinovirus infection in hospitalized adults is unrelated to genotype.
CONCLUSIONS: Infection with RV-A or RV-B was associated with greater severity of illness in our adult population; however, the association disappeared after controlling for confounders. PMID: 25015856 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: McCulloch DJ, Sears MH, Jacob JT, Lyon GM, Burd EM, Caliendo AM, Hill CE, Nix WA, Oberste MS, Kraft CS Tags: Am J Clin Pathol Source Type: research

Evaluation of contemporary prostate and urothelial lineage biomarkers in a consecutive cohort of poorly differentiated bladder neck carcinomas.
CONCLUSIONS: Novel IHC markers show improved diagnostic performance that enables positive and negative support for identifying histogenesis with the use of as few as two markers for this critical therapeutic distinction. PSA underperforms newer markers. PMID: 25015857 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Mohanty SK, Smith SC, Chang E, Luthringer DJ, Gown AM, Aron M, Amin MB Tags: Am J Clin Pathol Source Type: research

Total arsenic screening prior to fractionation enhances clinical utility and test utilization in the assessment of arsenic toxicity.
CONCLUSIONS: A total arsenic screen before fractionation reduces the number of samples requiring fractionation by more than 91%, supporting the use of a screen with a reflex-to-fractionation approach for urine arsenic. PMID: 25015858 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Hackenmueller SA, Strathmann FG Tags: Am J Clin Pathol Source Type: research

Acute myeloid leukemia with monosomal karyotype: morphologic, immunophenotypic, and molecular findings.
CONCLUSIONS: Outcome data showed that patients with AML-MK had significantly worse overall survival, disease-free survival, and complete response compared with the rest of the patients with AML as well as within the AML-MRC group. PMID: 25015859 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Weinberg OK, Ohgami RS, Ma L, Seo K, Ren L, Gotlib JR, Seetharam M, Cherry A, Arber DA Tags: Am J Clin Pathol Source Type: research

Successful triage of suspected hantavirus cardiopulmonary syndrome by peripheral blood smear review.
CONCLUSIONS: Our findings confirm that peripheral smear analysis is clinically useful in this endemic region. PMID: 25015860 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Dvorscak L, Czuchlewski DR Tags: Am J Clin Pathol Source Type: research