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Waste not, want not.
PMID: 25696787 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Hannon T Tags: Am J Clin Pathol Source Type: research

Screening for Lynch Syndrome: A No-Brainer: BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor.
PMID: 25696788 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Bellizzi AM Tags: Am J Clin Pathol Source Type: research

Quality pathology and laboratory diagnostic services are key to improving global health outcomes: improving global health outcomes is not possible without accurate disease diagnosis.
PMID: 25696789 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: African Strategies for Advancing Pathology Group Members Tags: Am J Clin Pathol Source Type: research

Effectiveness of multiple initiatives to reduce blood component wastage.
CONCLUSIONS: Relatively inexpensive interventions can have a prompt and dramatic impact on reducing blood wastage with regard to both cost and resource savings. PMID: 25696790 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Collins RA, Wisniewski MK, Waters JH, Triulzi DJ, Yazer MH Tags: Am J Clin Pathol Source Type: research

A Modified Lynch Syndrome Screening Algorithm in Colon Cancer: BRAF Immunohistochemistry Is Efficacious and Cost Beneficial.
CONCLUSIONS: BRAF V600E IHC was concordant between TMAs, biopsy specimens, and whole-section slides, suggesting biopsy specimens are as useful as whole sections. IHC remained cost beneficial compared with mutational analysis, even though more patients needed additional molecular testing to exclude Lynch syndrome. PMID: 25696791 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Roth RM, Hampel H, Arnold CA, Yearsley MM, Marsh WL, Frankel WL Tags: Am J Clin Pathol Source Type: research

Use of hTERT and HPV E6/E7 mRNA RT-qPCR TaqMan Assays in Combination for Diagnosing High-Grade Cervical Lesions and Malignant Tumors.
CONCLUSIONS: These data suggest that the combination of HPV E6/E7 and hTERT mRNA expression levels could be used in a complementary manner in diagnosing high-grade cervical lesions and malignant tumors and might be useful as a predictive marker in monitoring low-grade cervical lesions. PMID: 25696792 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Wang HY, Park S, Kim S, Lee D, Kim G, Kim Y, Park KH, Lee H Tags: Am J Clin Pathol Source Type: research

Effects of levonorgestrel-releasing intrauterine system on lymphangiogenesis of adenomyosis.
CONCLUSIONS: Treatment with the LNG-IUS resulted in reduced lymphangiogenesis and LVD in the endometrial and myometrial tissues of patients with adenomyosis. Reduced lymphangiogenesis may be one mechanism by which the LNG-IUS reduces adenomyosis-related symptoms. PMID: 25696793 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Cho S, Choi YS, Yun BH, Chon SJ, Jung YS, Kim HY, Park JH, Seo SK, Kim SH, Lee BS Tags: Am J Clin Pathol Source Type: research

Diagnostic and Prognostic Value of BCL2 Rearrangement in 53 Patients With Follicular Lymphoma Presenting as Primary Skin Lesions.
CONCLUSIONS: We observed that BCL2 rearrangement in PCFCL is rare, associated with initial positivity of staging (diagnostic value) or with secondary extracutaneous spreading (prognostic value). In selected cases with BCL2-CD10 coexpression, FISH testing could detect patients with poor outcome and require closer monitoring. PMID: 25696794 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Pham-Ledard A, Cowppli-Bony A, Doussau A, Prochazkova-Carlotti M, Laharanne E, Jouary T, Belaud-Rotureau MA, Vergier B, Merlio JP, Beylot-Barry M Tags: Am J Clin Pathol Source Type: research

Left-Sided Early-Onset vs Late-Onset Colorectal Carcinoma: Histologic, Clinical, and Molecular Differences.
CONCLUSIONS: Our results suggest that left-sided CRCs may present differential patterns of aberrant DNA methylation when they are separated by age. PMID: 25696795 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Pilozzi E, Maresca C, Duranti E, Giustiniani MC, Catalanotto C, Lucarelli M, Cogoni C, Ferri M, Ruco L, Zardo G Tags: Am J Clin Pathol Source Type: research

Interobserver Variability of Mitotic Index and Utility of PHH3 for Risk Stratification in Gastrointestinal Stromal Tumors.
CONCLUSIONS: PHH3 may thus be a valuable adjunct for risk stratification in GISTs. PMID: 25696796 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Alkhasawneh A, Reith JD, Toro TZ, Ayed AO, Lu X, George TJ, Duckworth LV Tags: Am J Clin Pathol Source Type: research

Impact of an educational intervention on the frequency of daily blood test orders for hospitalized patients.
CONCLUSIONS: Provider education and reminders can reduce the frequency of daily blood tests ordered by providers for hospitalized patients. This can decrease health care costs and may reduce the risk of complications such as anemia. PMID: 25696797 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Thakkar RN, Kim D, Knight AM, Riedel S, Vaidya D, Wright SM Tags: Am J Clin Pathol Source Type: research

Liver metastases of small intestine neuroendocrine tumors: ki-67 heterogeneity and world health organization grade discordance with primary tumors.
CONCLUSIONS: Intratumoral and intertumoral Ki-67 heterogeneity is common and positively correlated with tumor size. The presence of one or more grade 3 liver lesions predicts a worse prognosis. PMID: 25696798 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Shi C, Gonzalez RS, Zhao Z, Koyama T, Cornish TC, Hande KR, Walker R, Sandler M, Berlin J, Liu EH Tags: Am J Clin Pathol Source Type: research

Building capacity in laboratory medicine in Africa by increasing physician involvement: a laboratory medicine course for clinicians.
CONCLUSIONS: Knowledge and awareness of the role of the laboratory increased after participation in the course. Understanding of laboratory medicine principles by clinicians will likely improve use of laboratory services and build capacity in Africa. PMID: 25696799 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Guarner J, Amukele T, Mehari M, Gemechu T, Woldeamanuel Y, Winkler AM, Asrat D, Wilson ML, Del Rio C Tags: Am J Clin Pathol Source Type: research

Visual memory effects on intraoperator study design: determining a minimum time gap between case reviews to reduce recall bias.
CONCLUSIONS: Pathologists were capable of recalling from memory cases seen previously at 2 and 4 weeks. Recall rates may be sufficiently high to affect intraobserver study design. PMID: 25696800 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Campbell WS, Talmon GA, Foster KW, Baker JJ, Smith LM, Hinrichs SH Tags: Am J Clin Pathol Source Type: research

Immunohistochemical distinction of primary sweat gland carcinoma and metastatic breast carcinoma: can it always be accomplished reliably?
CONCLUSIONS: These data suggest that p63 and CK5/6 are specific determinants for sweat gland carcinoma in the stated setting. In the absence of those analytes, metastatic breast carcinoma cannot always be identified to the exclusion of a primary tumor. This diagnostic scenario continues to require the procurement of a detailed clinical history regarding the number and duration of skin lesions in any given case. PMID: 25696802 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Mentrikoski MJ, Wick MR Tags: Am J Clin Pathol Source Type: research

VE1 Antibody Is Not Highly Specific for the BRAF V600E Mutation in Thyroid Cytology Categories With the Exception of Malignant Cases.
CONCLUSIONS: VE1 immunocytochemistry in thyroid FNAC as a screening test for BRAF mutations is highly specific for malignant category cases but can be suboptimal due to its high false-positive rate for the nonmalignant cases. PMID: 25696803 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Lee SR, Yim H, Han JH, Lee KB, Lee J, Soh EY, Kim DJ, Chung YS, Jeong SY, Sheen SS, Park SH, Kim JH Tags: Am J Clin Pathol Source Type: research

Normal villous architecture with increased intraepithelial lymphocytes: a duodenal manifestation of crohn disease.
CONCLUSIONS: We propose that Crohn disease be included in the differential diagnosis for increased IELs with normal villous architecture in duodenal biopsy specimens, particularly when gastric biopsy specimens show focal gastritis. PMID: 25696804 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Patterson ER, Shmidt E, Oxentenko AS, Enders FT, Smyrk TC Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25696806 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Media Review.
PMID: 25696807 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Yantiss RK Tags: Am J Clin Pathol Source Type: research

Media Review.
PMID: 25696808 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Hoda SA, Ginter PS Tags: Am J Clin Pathol Source Type: research

Clinical utility of lactate dehydrogenase: a historical perspective.
PMID: 25596240 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Jialal I, Sokoll LJ Tags: Am J Clin Pathol Source Type: research

Detection of Human Papillomavirus 16, 18, and 45 in Women With ASC-US Cytology and the Risk of Cervical Precancer: Results From the CLEAR HPV Study.
CONCLUSIONS: We demonstrated that AHPV-GT is a reliable and effective test for cervical cancer risk stratification in women with an ASC-US cytology diagnosis. PMID: 25596241 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Castle PE, Cuzick J, Stoler MH, Wright TC, Reid JL, Dockter J, Giachetti C, Getman D Tags: Am J Clin Pathol Source Type: research

Automatic recognition of atypical lymphoid cells from peripheral blood by digital image analysis.
CONCLUSIONS: The method reaches a high precision in the recognition of five different types of lymphoid cells and could allow for the design of a diagnosis support tool in the future. PMID: 25596242 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Alférez S, Merino A, Bigorra L, Mujica L, Ruiz M, Rodellar J Tags: Am J Clin Pathol Source Type: research

The Vascular Marker CD31 Also Highlights Histiocytes and Histiocyte-Like Cells Within Cutaneous Tumors.
CONCLUSIONS: Our results indicate that CD31 can mark lesional cells and imitate vascular tumors in cutaneous histiocytomas and histiocytoma mimics, an error that can be avoided by using a panel of antibodies. PMID: 25596243 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Vanchinathan V, Mizramani N, Kantipudi R, Schwartz EJ, Sundram UN Tags: Am J Clin Pathol Source Type: research

Detection of acetylcholine receptor modulating antibodies by flow cytometry.
CONCLUSIONS: The new flow cytometric method using the RD cell platform provided higher quality clinical results, a more robust and efficient assay format, a significant cost savings, and less environmental burden. PMID: 25596244 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Lozier BK, Haven TR, Astill ME, Hill HR Tags: Am J Clin Pathol Source Type: research

Adequacy of core needle biopsy specimens and fine-needle aspirates for molecular testing of lung adenocarcinomas.
CONCLUSIONS: When paraffin-embedded tissue is used for molecular testing of lung cancer, CNB specimens are more likely than FNA specimens to provide adequate tissue for molecular testing. Obtaining a sufficient FNA specimen depends on the tumor size and the individual performing the biopsy. PMID: 25596245 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Schneider F, Smith MA, Lane MC, Pantanowitz L, Dacic S, Ohori NP Tags: Am J Clin Pathol Source Type: research

Bone marrow necrosis: ten-year retrospective review of bone marrow biopsy specimens.
CONCLUSIONS: The causes of bone marrow necrosis are diverse but should always prompt careful assessment for malignancy and infectious etiology. PMID: 25596246 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Wool GD, Deucher A Tags: Am J Clin Pathol Source Type: research

Flow cytometric analysis of lymphoid enhancer-binding factor 1 in diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma.
CONCLUSIONS: Flow cytometric analysis of LEF1 is sufficient to differentiate CLL/SLL from other small B-cell lymphomas and may serve as a useful tool in the diagnosis of CLL/SLL. PMID: 25596247 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Amador-Ortiz C, Goolsby CL, Peterson LC, Wolniak KL, McLaughlin JL, Gao J, Chen YH Tags: Am J Clin Pathol Source Type: research

Thyroid carcinoma showing thymus-like elements: a clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis.
CONCLUSIONS: GLUT-1 can be used as a novel biomarker for CASTLE, and combined detection of GLUT-1 with CD5 and CD117 aids in the diagnosis of this tumor. Aberrant expression of Bcl-2, p53, p16, E-cadherin, EGFR, C-KIT, and HER-2 may play important roles in the development of CASTLE. PMID: 25596248 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Wang YF, Liu B, Fan XS, Rao Q, Xu Y, Xia QY, Yu B, Shi SS, Zhou XJ Tags: Am J Clin Pathol Source Type: research

A hybrid approach to urine drug testing using high-resolution mass spectrometry and select immunoassays.
CONCLUSIONS: The hybrid approach to urine drug testing provides a simplified and analytically specific testing process that minimizes the need for secondary confirmation. PMID: 25596249 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: McMillin GA, Marin SJ, Johnson-Davis KL, Lawlor BG, Strathmann FG Tags: Am J Clin Pathol Source Type: research

Laboratory measurements of the oral direct factor xa inhibitor edoxaban: comparison of prothrombin time, activated partial thromboplastin time, and thrombin generation assay.
CONCLUSIONS: PT had disadvantages of a large variability among different PT reagents. aPTT could be used as a conventional and convenient test with a smaller variation among reagents. Thrombin generation was the most sensitive assay. PMID: 25596250 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Morishima Y, Kamisato C Tags: Am J Clin Pathol Source Type: research

Enhanced FHL2 and TGF-β1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas.
CONCLUSIONS: Enhanced FHL2 and TGF-β1 expression is correlated with poor survival in human malignant melanoma. Protumorigenic effects of autocrine TGF-β1 secretion might be exerted by induction of FHL2 expression in melanoma cells. Since melanomas treated with targeted therapies often do not show sufficient response rates, inhibition of FHL2 and/or TGF-β1 might be a promising therapeutic approach. PMID: 25596251 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Westphal P, Mauch C, Florin A, Czerwitzki J, Olligschläger N, Wodtke C, Schüle R, Büttner R, Friedrichs N Tags: Am J Clin Pathol Source Type: research

Pathologic Diagnostics of HER2 Positivity in Gastroesophageal Adenocarcinoma.
CONCLUSIONS: The currently used standardized HER2 scoring system is an excellent, clinically applicable method to establish HER2 status in appropriately educated and trained pathologists. PMID: 25596252 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Koopman T, Louwen M, Hage M, Smits MM, Imholz AL Tags: Am J Clin Pathol Source Type: research

Subcutaneous panniculitis-like T-cell lymphoma with bone marrow involvement.
CONCLUSIONS: SPTCL may rarely involve the bone marrow. Bone marrow infiltrates show a similar morphologic and immunophenotypic appearance to those in the subcutaneous fibroadipose tissue, including rimming of adipocytes by neoplastic lymphocytes. PMID: 25596253 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Brown NA, Ross CW, Gudjonsson JE, Wale D, Pawarode A, Maillard I, Hristov AC Tags: Am J Clin Pathol Source Type: research

Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma.
CONCLUSIONS: This unique case provides new insight into the pathogenesis of MCLIS. PMID: 25596254 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Sloan C, Xiong QB, Crivaro A, Steinman S, Bagg A Tags: Am J Clin Pathol Source Type: research

Solid pseudopapillary neoplasm collides with a well-differentiated pancreatic endocrine neoplasm in an adult man: case report and review of histogenesis.
CONCLUSIONS: A comparative analysis of immunoprofiles of these tumors yielded interesting findings, enabling us to postulate that SPNs may originate from a multipotential primordial cell that may follow different differentiation pathways, such as endocrine, epithelial, and acinar. The ultrastructures and immunophenotypic characteristics appear to support this hypothesis. PMID: 25596255 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Yan SX, Adair CF, Balani J, Mansour JC, Gokaslan ST Tags: Am J Clin Pathol Source Type: research

Cyclin D1-Positive Diffuse Large B-Cell Lymphoma With IGH-CCND1 Translocation and BCL6 Rearrangement: A Report of Two Cases.
CONCLUSIONS: Our study demonstrates convincingly that IGH-CCND1 rearrangement leading to cyclin D1 overexpression can occur in DLBCL and pose a potential diagnostic pitfall, requiring thorough knowledge of the clinicopathologic findings to allow accurate discrimination from a blastoid or pleomorphic MCL. The coexistence of IGH-CCND1 and IGH-BCL6 rearrangements suggest that BCL6 and cyclin D1 may cooperate in the pathogenesis of DLBCL. PMID: 25596256 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Al-Kawaaz M, Mathew S, Liu Y, Gomez ML, Chaviano F, Knowles DM, Orazi A, Tam W Tags: Am J Clin Pathol Source Type: research

A challenging diagnosis: crystal-storing histiocytosis in plasma cell myeloma.
CONCLUSIONS: The diagnosis was challenging; the bone marrow findings resembled features of other histiocytic disorders. The use of immunohistochemistry enabled the diagnosis of CSH in the presence of plasma cell myeloma. PMID: 25596257 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Lee JS, Im K, Park SN, Park HS, Kim JA, Choi Q, Kim SY, Cha CH, Oh HS, Kim IH, Lee DS Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25596258 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Bone marrow assessment in the diagnosis of acquired hemophagocytic lymphohistiocytosis in adults.
PMID: 25596259 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Machaczka M, Klimkowska M, Ho C, Yao X, Tian L, Li FY, Podoltsev N, Xu ML Tags: Am J Clin Pathol Source Type: research

Gallbladders: another source of radiation in the histology laboratory.
PMID: 25596260 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Renshaw AA, Gould EW, Tershakovec G Tags: Am J Clin Pathol Source Type: research

Pathology and malpractice.
PMID: 25596261 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Gatter K Tags: Am J Clin Pathol Source Type: research

Safety considerations in the laboratory testing of specimens suspected or known to contain ebola virus.
PMID: 25511134 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2014 Category: Pathology Authors: Iwen PC, Smith PW, Hewlett AL, Kratochvil CJ, Lisco SJ, Sullivan JN, Gibbs SG, Lowe JJ, Fey PD, Herrera VL, Sambol AR, Wisecarver JL, Hinrichs SH Tags: Am J Clin Pathol Source Type: research

Physician productivity: issues and controversies.
PMID: 25511135 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2014 Category: Pathology Authors: Storfa AH, Wilson ML Tags: Am J Clin Pathol Source Type: research

Starting at the beginning, ending at the end.
PMID: 25511136 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2014 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

Confidence, knowledge, and skills at the beginning of residency: a survey of pathology residents.
CONCLUSIONS: Respondents gained exposure to pathology primarily through elective rotations, and most felt the elective experience prepared them for pathology residency. However, elective time may be enhanced by providing opportunities for students to increase hands-on experience and understanding of resident duties. PMID: 25511137 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2014 Category: Pathology Authors: Hsieh CM, Nolan NJ Tags: Am J Clin Pathol Source Type: research

Cytogenetic and Flow Cytometry Evaluation of Richter Syndrome Reveals MYC, CDKN2A, IGH Alterations With Loss of CD52, CD62L and Increase of CD71 Antigen Expression as the Most Frequent Recurrent Abnormalities.
CONCLUSIONS: Newly diagnosed RS is an oncologic emergency, and a quick diagnostic decision is crucial in clinical practice. Therefore, in patients with CLL/SLL and rapidly enlarging asymmetric lymphadenopathy and/or extranodal tumors, we strongly advise FCM of fine-needle aspiration biopsy (FNAB) material, including CD62L, CD52, and CD71 analysis as well as assessment of karyotype and at least MYC abnormalities by FISH of the same FNAB material. Loss of CD52 expression in RS most likely predicts resistance to alemtuzumab therapy, which is frequently used in CLL. PMID: 25511139 [PubMed - in process] (Source: American Jo...
Source: American Journal of Clinical Pathology - December 20, 2014 Category: Pathology Authors: Woroniecka R, Rymkiewicz G, Grygalewicz B, Błachnio K, Rygier J, Jarmuż-Szymczak M, Ratajczak B, Pieńkowska-Grela B Tags: Am J Clin Pathol Source Type: research

Lymphocytic cholecystitis/cholangitis.
CONCLUSIONS: The term lymphocytic cholecystitis/cholangitis is proposed. The potential clinical implications and pathogenesis of this inflammatory pattern and the differential diagnosis with other forms of acalculous cholecystitis are discussed. PMID: 25511140 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2014 Category: Pathology Authors: Jessurun J Tags: Am J Clin Pathol Source Type: research

Enhanced creatinine and estimated glomerular filtration rate reporting to facilitate detection of acute kidney injury.
CONCLUSION: While both creatinine reference limits and simple delta checks are insensitive for AKI identification, a simple algorithm can be implemented within a common laboratory information system to enhance AKI identification. PMID: 25511141 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2014 Category: Pathology Authors: Baron JM, Cheng XS, Bazari H, Bhan I, Lofgren C, Jaromin RT, Lewandrowski KB, Dighe AS Tags: Am J Clin Pathol Source Type: research

Most clinical laboratory testing in kampala occurs in high-volume, high-quality laboratories or low-volume, low-quality laboratories: a tale of two cities.
CONCLUSIONS: Clinical laboratory density in Kampala (1/1,781 persons) is high, approaching that in the United States (1/1,347 persons). Low-volume/low-quality and high-volume/high-quality laboratories do 90% of the daily aggregate testing. Quality improvement (QI) schemes for Africa must be appropriate to low-volume laboratories as well as to the large laboratories that have been the focus of previous QI efforts. PMID: 25511142 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2014 Category: Pathology Authors: Amukele TK, Schroeder LF, Jackson JB, Elbireer A Tags: Am J Clin Pathol Source Type: research