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American Journal of Clinical Pathology

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Learning to be a consultant: what should be taught.
PMID: 25125615 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

An analysis of clinical consultation activities in clinical pathology: who requests help and why.
CONCLUSIONS: At our laboratory, consultation requests primarily originate from primary care physicians. Consultation requests vary by caller type. PMID: 25125616 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Schmidt RL, Panlener J, Hussong JW Tags: Am J Clin Pathol Source Type: research

Loss of blast heterogeneity in myelodysplastic syndrome and other chronic myeloid neoplasms.
CONCLUSIONS: Analysis of a limited antibody panel with a focus on CD13/HLA-DR expression provides relatively high specificity and sensitivity for the detection of myeloid neoplasms. PMID: 25125617 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Jevremovic D, Timm MM, Reichard KK, Morice WG, Hanson CA, Viswanatha DS, Howard MT, Nguyen PL Tags: Am J Clin Pathol Source Type: research

Rapid detection of the active cardiac glycoside convallatoxin of lily of the valley using Loci digoxin assay.
CONCLUSIONS: LOCI digoxin assay can be used for rapid detection of convallatoxin, and Digibind can bind convallatoxin in vitro. PMID: 25125619 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Welsh KJ, Huang RS, Actor JK, Dasgupta A Tags: Am J Clin Pathol Source Type: research

Mesothelin expression in pancreatic mucinous cysts.
CONCLUSION: Our findings suggest that MLSN can be used as a marker of neoplastic transformation of epithelial cells in pancreatic mucinous cysts. The findings can help identify neoplastic mucinous epithelium. PMID: 25125620 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Frank R, Li S, Ahmad NA, Sepulveda AR, Jhala NC Tags: Am J Clin Pathol Source Type: research

Evaluation of Napsin A, TTF-1, p63, p40, and CK5/6 Immunohistochemical Stains in Pulmonary Neuroendocrine Tumors.
CONCLUSION: Pulmonary neuroendocrine tumors have a distinct but nonspecific profile on IHC panel commonly applied to subclassify NSCLCs. They are napsin A-/p40-/p63-/CK5/6-/TTF-1±. Recognizing this profile may have value in separating neuroendocrine tumors from NSCLCs. PMID: 25125621 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Zhang C, Schmidt LA, Hatanaka K, Thomas D, Lagstein A, Myers JL Tags: Am J Clin Pathol Source Type: research

A dual-fixed neutrophil substrate improves interpretation of antineutrophil cytoplasmic antibodies by indirect immunofluorescence.
CONCLUSIONS: Concomitant staining on formalin fixation of IIF-positive ethanol-fixed ANCA samples improves the interpretation of ANCA testing and is predictive of vasculitis autoantigens MPO and PR3. PMID: 25125622 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Lin MW, Silvestrini RA, Culican S, Campbell D, Fulcher DA Tags: Am J Clin Pathol Source Type: research

Platelet mapping assay interference due to platelet activation in heparinized samples.
CONCLUSIONS: Unanticipated platelet activation/aggregation occurring in the heparinized TEGPM samples lead to erroneous percent inhibition results. PMID: 25125623 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Nelles NJ, Chandler WL Tags: Am J Clin Pathol Source Type: research

Aggressive B-Cell Lymphomas With Translocations Involving BCL6 and MYC Have Distinct Clinical-Pathologic Characteristics.
CONCLUSIONS: B-cell lymphomas with translocations involving MYC and BCL6 have morphologic and immunophenotypic features suggestive of Burkitt lymphoma or gray zone lymphoma, and they tend to be diagnosed mainly in women, often in extranodal locations. PMID: 25125624 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Turakhia SK, Hill BT, Dufresne SD, Nakashima MO, Cotta CV Tags: Am J Clin Pathol Source Type: research

Aberrations of MYC Are a Common Event in B-Cell Prolymphocytic Leukemia.
CONCLUSIONS: These results suggest that deregulation of MYC plays an important role in the pathogenesis of B-PLL and expands the spectrum of B-cell neoplasms associated with aberrations of MYC. PMID: 25125625 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Flatley E, Chen AI, Zhao X, Jaffe ES, Dunlap JB, Pittaluga S, Abdullah S, Olson SB, Spurgeon SE, Fan G Tags: Am J Clin Pathol Source Type: research

Recognition and discrimination of tissue-marking dye color by surgical pathologists: recommendations to avoid errors in margin assessment.
CONCLUSIONS: Pathologists have difficulty identifying and distinguishing certain colors of TMDs. The combined use of certain colors of TMDs (yellow/orange/red, blue/violet, and red/violet) within the same specimen should be avoided to decrease the risk of inaccurately reporting specimen margins. PMID: 25125626 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Williams AS, Hache KD Tags: Am J Clin Pathol Source Type: research

Significant histologic features differentiating cellular fibroadenoma from phyllodes tumor on core needle biopsy specimens.
CONCLUSIONS: The presence of mitoses (three or more) and/or total histologic features of three or more on CNB specimens were the most helpful features in predicting PT on excision. PMID: 25125627 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Yasir S, Gamez R, Jenkins S, Visscher DW, Nassar A Tags: Am J Clin Pathol Source Type: research

Utility of immunofluorescence testing for vascular IgA in adult patients with leukocytoclastic vasculitis.
CONCLUSIONS: Our data confirm that vascular IgA is nonspecific and also demonstrate that the utility of IF studies for vasculitis is influenced by the clinical presentation and the clinician's level of suspicion for HSP. Our data show that the clinical features and the overall clinical impression are helpful in selecting which patients are most likely to benefit from IF testing. PMID: 25125628 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Larson AR, Granter SR Tags: Am J Clin Pathol Source Type: research

Performance Characteristics of Nested Polymerase Chain Reaction vs Real-Time Polymerase Chain Reaction Methods for Detecting Mycobacterium tuberculosis Complex in Paraffin-Embedded Human Tissues.
CONCLUSIONS: Well-designed RT-PCR and N-PCR can effectively identify MTB in FFPE specimens. PMID: 25125630 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Seo AN, Park HJ, Lee HS, Park JO, Chang HE, Nam KH, Choe G, Park KU Tags: Am J Clin Pathol Source Type: research

Correlation between biological marker expression and fluorine-18 fluorodeoxyglucose uptake in hepatocellular carcinoma.
CONCLUSIONS: Our study indicates that FDG uptake is associated with the expression of pSTAT3, HIF1α, and GLUT1 in hepatocellular carcinoma. The expression of these proteins shows a correlation with poor differentiation and vascular invasion. PMID: 25125631 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Mano Y, Aishima S, Kubo Y, Tanaka Y, Motomura T, Toshima T, Shirabe K, Baba S, Maehara Y, Oda Y Tags: Am J Clin Pathol Source Type: research

Utility of nine-color, 11-parameter flow cytometry for detection of plasma cell neoplasms: a comparison with bone marrow morphologic findings and concurrent m-protein studies in serum and urine.
CONCLUSIONS: The nine-color analytic cocktail eliminates duplication of PC gating reagents required for evaluation of the same epitopes using a five- or six-color approach. Fewer analytic cocktails result in lower instrument acquisition times per case, a significant factor for the large data sets required for optimal residual disease assessment. Finally, concurrent analysis of nine epitopes and two light scatter parameters aids detection of residual disease, particularly when it is mixed with polyclonal PCs. PMID: 25125632 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Behdad A, Ross CW, Jacques J, Kota U, Keren D, Stoolman L Tags: Am J Clin Pathol Source Type: research

Value-based flow testing of chronic lymphoproliferative disorders: a quality improvement project to develop an algorithm to streamline testing and reduce costs.
CONCLUSIONS: We project this approach will result in a 40% decrease in antibody utilization. PMID: 25125633 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Authors: Oberley MJ, Fitzgerald S, Yang DT, Morgan A, Johnson J, Leith C Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25125634 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 19, 2014 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Clinical laboratory directors.
PMID: 25015851 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

Large B-Cell Lymphoma Rich in PD-1+ T Cells: An Overlooked Subtype of Diffuse Large B-Cell Lymphoma?
PMID: 25015852 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Hartmann S, Hansmann ML Tags: Am J Clin Pathol Source Type: research

The practice of clinical pathology: a quantitative description of laboratory director activities at a large academic medical center.
CONCLUSIONS: Although the activities of clinical laboratory directors have been described elsewhere, this is the first study detailing the effort allocated to these various activities in quantitative terms. The study demonstrated that less than 20% of an academic laboratory director's effort involves administrative activities that could potentially be performed by a professional manager lacking doctorate level medical or scientific expertise. PMID: 25015853 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Branda JA, Dighe AS, Dzik W, Ferraro MJ, Flood J, Lee-Lewandrowski E, Makar R, Mandokolathur M, Rosenberg ES, Saidman S, Sluss P, Sohani AR, Stowell C, Van Cott EM, Lewandrowski KB Tags: Am J Clin Pathol Source Type: research

Large B-Cell Lymphomas Poor in B Cells and Rich in PD-1+ T Cells Can Mimic T-Cell Lymphomas.
CONCLUSIONS: Large B-cell lymphomas poor in B cells and rich in T cells can have diffuse sheets of reactive PD-1+ T cells, some with atypical morphologic and immunophenotypic features mimicking a T-cell lymphoma. Careful assessment of the immunoarchitecture and background inflammatory and stromal cells can prevent erroneous diagnoses in such cases. PMID: 25015854 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Ohgami RS, Zhao S, Natkunam Y Tags: Am J Clin Pathol Source Type: research

Reduced glucocorticoid receptor expression predicts bladder tumor recurrence and progression.
CONCLUSIONS: GR expression was downregulated in bladder tumors compared with nonneoplastic bladder tumors and in high-grade/MI tumors compared with low-grade/NMI tumors. Decreased expression of GR, as an independent prognosticator, predicted recurrence of NMI tumors. These results support experimental evidence suggesting an inhibitory role of GR signals in bladder cancer outgrowth. PMID: 25015855 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Ishiguro H, Kawahara T, Zheng Y, Netto GJ, Miyamoto H Tags: Am J Clin Pathol Source Type: research

Severity of rhinovirus infection in hospitalized adults is unrelated to genotype.
CONCLUSIONS: Infection with RV-A or RV-B was associated with greater severity of illness in our adult population; however, the association disappeared after controlling for confounders. PMID: 25015856 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: McCulloch DJ, Sears MH, Jacob JT, Lyon GM, Burd EM, Caliendo AM, Hill CE, Nix WA, Oberste MS, Kraft CS Tags: Am J Clin Pathol Source Type: research

Evaluation of contemporary prostate and urothelial lineage biomarkers in a consecutive cohort of poorly differentiated bladder neck carcinomas.
CONCLUSIONS: Novel IHC markers show improved diagnostic performance that enables positive and negative support for identifying histogenesis with the use of as few as two markers for this critical therapeutic distinction. PSA underperforms newer markers. PMID: 25015857 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Mohanty SK, Smith SC, Chang E, Luthringer DJ, Gown AM, Aron M, Amin MB Tags: Am J Clin Pathol Source Type: research

Total arsenic screening prior to fractionation enhances clinical utility and test utilization in the assessment of arsenic toxicity.
CONCLUSIONS: A total arsenic screen before fractionation reduces the number of samples requiring fractionation by more than 91%, supporting the use of a screen with a reflex-to-fractionation approach for urine arsenic. PMID: 25015858 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Hackenmueller SA, Strathmann FG Tags: Am J Clin Pathol Source Type: research

Acute myeloid leukemia with monosomal karyotype: morphologic, immunophenotypic, and molecular findings.
CONCLUSIONS: Outcome data showed that patients with AML-MK had significantly worse overall survival, disease-free survival, and complete response compared with the rest of the patients with AML as well as within the AML-MRC group. PMID: 25015859 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Weinberg OK, Ohgami RS, Ma L, Seo K, Ren L, Gotlib JR, Seetharam M, Cherry A, Arber DA Tags: Am J Clin Pathol Source Type: research

Successful triage of suspected hantavirus cardiopulmonary syndrome by peripheral blood smear review.
CONCLUSIONS: Our findings confirm that peripheral smear analysis is clinically useful in this endemic region. PMID: 25015860 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Dvorscak L, Czuchlewski DR Tags: Am J Clin Pathol Source Type: research

Frozen section of placental membranes and umbilical cord: an aid to early postpartum diagnosis of intra-amniotic infection.
CONCLUSIONS: We conclude that FS is a reasonably sensitive screening technique, correlating well with conventional assessment, without significantly different interobserver variability. PMID: 25015861 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Mahe E, Hamid J, Terry J, Jansen JW, Bourgeois J, Arredondo-Marin J Tags: Am J Clin Pathol Source Type: research

Sporadic lymphoplasmacytic cholecystitis: a clinicopathologic entity.
CONCLUSIONS: While obstructive LPC is traditionally described as acalculous, chronic cholecystitis, we show this inflammatory pattern occurs both in the presence of gallstones and outside of previously described disease categories. In addition, LPC occurs in a unique patient demographic (older men), often presenting similarly to acute cholecystitis. PMID: 25015862 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Hammer ST, Appelman HD Tags: Am J Clin Pathol Source Type: research

High prevalence of atypical hyperplasia in the endometrium of patients with epithelial ovarian cancer.
CONCLUSIONS: Apart from synchronous endometrial carcinoma, endometrial premalignancies should be taken into account when determining optimal treatment for women diagnosed with EOC. PMID: 25015863 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Mingels MJ, Masadah R, Geels YP, Otte-Höller I, de Kievit IM, van der Laak JA, van Ham MA, Bulten J, Massuger LF Tags: Am J Clin Pathol Source Type: research

Abnormal cervical cytology after allogeneic bone marrow transplantation.
CONCLUSIONS: Pap smears after BMT show a high incidence of dysplastic lesions. Moreover, conditioning including busulfan is often associated with therapy-related cytologic atypia, which may lead to unnecessary colposcopies and biopsies. Knowledge of the patient's history and a careful evaluation of the smears are mandatory in these cases. PMID: 25015864 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Negri G, Herz M, Deola S, Piccin A, Casini M, Babich B, Tauber M, Messini S, Marucci MR, Vittadello F Tags: Am J Clin Pathol Source Type: research

Alternate clonal dominance in richter transformation presenting as extranodal diffuse large B-cell lymphoma and synchronous classic hodgkin lymphoma.
CONCLUSIONS: In this case, the elaborate clinical and molecular picture may be correlated to an alternate dominance of two distinct clonal populations probably influenced by therapeutic and environmental factors. PMID: 25015865 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Di Bernardo A, Mussetti A, Aiello A, De Paoli E, Cabras AD Tags: Am J Clin Pathol Source Type: research

Well-differentiated papillary mesothelioma of the peritoneum: a diagnostic dilemma on fine-needle aspiration cytology.
CONCLUSIONS: This article highlights the cytologic features of WDPMP with relevant review of the literature and differential diagnosis. PMID: 25015866 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Nasit JG, Dhruva G Tags: Am J Clin Pathol Source Type: research

Cutaneous intravascular natural killer-cell lymphoma: a case report and review of the literature.
CONCLUSIONS: IVNKL should be distinguished from extranodal NK/T-cell lymphoma (nasal type) and aggressive NK-cell leukemia. These three diseases have a similar phenotype and are all related to Epstein-Barr virus infection. However, the pathogenesis of similarities and differences needs further study. In particular, IVNKL is quite unusual. The treatment of IVNKL is difficult, and the prognosis is poor. Currently, IVNKL is not included in the World Health Organization classification subtypes and has been classified into NK/T-cell lymphoma (nasal type). However, in view of the unique characteristics of this disease, we propos...
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Liu Y, Zhang W, An J, Li H, Liu S Tags: Am J Clin Pathol Source Type: research

Neonatal silver-russell syndrome with maternal uniparental heterodisomy, trisomy 7 mosaicism, and dysplasia of the cerebellum.
CONCLUSIONS: This unusual association of SRS and dysplasia of the cerebellum might be related to the presence of the trisomy 7 mosaicism on the cerebellum. Our observation strengthens the hypothesis that the phenotype observed in patients with SRS with UPD(7)m might also result from an undetected low level of trisomy 7 mosaicism that could best be revealed by performing cytogenetic investigations. PMID: 25015868 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Abdelhedi F, El Khattabi L, Cuisset L, Tsatsaris V, Viot G, Druart L, Lebbar A, Dupont JM Tags: Am J Clin Pathol Source Type: research

Massive Dissemination From Spinal Cord Gangliogliomas Negative for BRAF V600E: Report of Two Rare Adult Cases.
CONCLUSIONS: We document two rare cases of massively metastatic spinal cord GGs in adult patients who were negative for BRAF V600E mutations via multiple methods. PMID: 25015869 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Lummus SC, Aisner DL, Sams SB, Foreman NK, Lillehei KO, Kleinschmidt-DeMasters BK Tags: Am J Clin Pathol Source Type: research

Misleading hemoglobin a1c levels in a patient with paroxysmal nocturnal hemoglobinuria.
CONCLUSIONS: Hemoglobin A1c levels must be interpreted with caution in patients with hematologic diseases that change RBC survival. Serum fructosamine and glycated albumin measurements are alternative measures of time-averaged blood glucose control and may be useful in this subset of patients. PMID: 25015870 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Xia D, McShine R, Berg AH Tags: Am J Clin Pathol Source Type: research

Multiple Macroenzymes in a Patient With AIDS: Diagnosis Using Ultrafiltration.
CONCLUSIONS: A previous report shows that in cases of excess immunoglobulin, PEG coprecipitates monomeric enzymes along with serum globulins, causing false-positive reporting of macroenzymes. This may explain the discrepancy between PEG and UF results in the presence of hypergammaglobulinemia, making UF a better method of detection in these circumstances. PMID: 25015871 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Wyness SP, Yee MA, La'ulu SL, Tosiello L, Straseski JA Tags: Am J Clin Pathol Source Type: research

Necrotizing fasciitis after breast augmentation: rapid microbiologic detection by using sonication of removed implants and microcalorimetry.
CONCLUSION: Microcalorimetry will have a benefit in conditions in which rapid diagnosis of infection is important. PMID: 25015872 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Yusuf E, Steinrücken J, Nordback S, Trampuz A Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25015873 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Tags: Am J Clin Pathol Source Type: research

The Interpretation of LSIL-H.
PMID: 25015874 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: Castle PE, Zhao C, Austin MR Tags: Am J Clin Pathol Source Type: research

Team-based learning.
PMID: 24926077 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2014 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

Do not assume: information flow and the electronic medical record.
PMID: 24926078 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2014 Category: Pathology Authors: Meier FA Tags: Am J Clin Pathol Source Type: research

The Effects of Under 6 Hours of Formalin Fixation on Hormone Receptor and HER2 Expression in Invasive Breast Cancer: A Systematic Review.
CONCLUSIONS: Available data on the effect of brief fixation on receptor status are limited. However, brief fixation of very highly expressing breast cancers does not seem to alter ER, PR, and HER2 status. Nevertheless, scoring inconsistencies have been observed. Further research is required in larger study populations with more low-expressing cases for future validation. PMID: 24926080 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2014 Category: Pathology Authors: Kalkman S, Barentsz MW, van Diest PJ Tags: Am J Clin Pathol Source Type: research

Team-based learning in a pathology residency training program.
CONCLUSIONS: The use of TBL promotes teamwork and learning in a pathology residency program. Residents scored higher on the readiness assurance tests when working in teams, demonstrating the effectiveness of team learning and achievement. In addition, the Accreditation Council for Graduate Medical Education competencies of professionalism and interpersonal and communication skills were further enhanced by incorporating TBL into pathology residency training. PMID: 24926081 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2014 Category: Pathology Authors: Brandler TC, Laser J, Williamson AK, Louie J, Esposito MJ Tags: Am J Clin Pathol Source Type: research

Evaluation of Anti-PLA2R1 as Measured by a Novel ELISA in Patients With Idiopathic Membranous Nephropathy: A Cohort Study.
CONCLUSIONS: ELISA performs excellently in differentiating idiopathic from secondary MN. Furthermore, ELISA shared high agreement with WB and IIF. PMID: 24926082 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2014 Category: Pathology Authors: Timmermans SA, Damoiseaux JG, Heerings-Rewinkel PT, Ayalon R, Beck LH, Schlumberger W, Salant DJ, van Paassen P, Tervaert JW, Limburg Renal Registry Tags: Am J Clin Pathol Source Type: research

Laboratory turnaround times in response to an abrupt increase in specimen testing after a natural disaster.
CONCLUSIONS: The increase in specimen numbers affected short- and long-duration test TATs differently. Streamlining and automating processes reduced registration and analysis times. Increased transport time was outside the control of the laboratory. PMID: 24926083 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2014 Category: Pathology Authors: Taylor K, George P, Deely JM Tags: Am J Clin Pathol Source Type: research

Clinical Performance of the BD Onclarity HPV Assay Using an Adjudicated Cohort of BD SurePath Liquid-Based Cytology Specimens.
CONCLUSIONS: The clinical performance of The BD Onclarity HPV Assay with respect to histology end points was similar to HC2. Moreover, discordant analysis revealed improved performance of the BD assay with respect to ability to provide extended genotyping information and lack of cross-reactivity with low-risk HPV types associated with cellular abnormalities. The relative risks for CIN 3 disease for HPV 31 and HPV 33/58 (combined) were comparable to that of HPV 18 in this population, suggesting that these genotypes may warrant monitoring in future studies. PMID: 24926084 [PubMed - in process] (Source: American Journal o...
Source: American Journal of Clinical Pathology - June 18, 2014 Category: Pathology Authors: Wright TC, Stoler MH, Agreda PM, Beitman GH, Gutierrez EC, Harris JM, Koch KR, Kuebler M, LaViers WD, Legendre BL, Leitch SV, Maus CE, McMillian RA, Nussbaumer WA, Palmer ML, Porter MJ, Richart GA, Schwab RJ, Vaughan LM Tags: Am J Clin Pathol Source Type: research

APOA1 mRNA Expression in Ovarian Serous Carcinoma Effusions Is a Marker of Longer Survival.
CONCLUSIONS: APOA1 and GPX3 mRNA levels on qRT-PCR effectively differentiate ovarian from breast carcinoma. APOA1 may be a novel prognostic marker in metastatic serous carcinoma. PMID: 24926085 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2014 Category: Pathology Authors: Stavnes HT, Nymoen DA, Hetland Falkenthal TE, Kærn J, Tropé CG, Davidson B Tags: Am J Clin Pathol Source Type: research