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The challenge of integrating informatics training during residency.
PMID: 25389323 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Riben M Tags: Am J Clin Pathol Source Type: research

Napsin a: another milestone in the subclassification of ovarian carcinoma.
PMID: 25389324 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Köbel M, Duggan MA Tags: Am J Clin Pathol Source Type: research

Primary care physicians and the laboratory: now and the future.
PMID: 25389325 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Marques MB, Hickner J, Thompson PJ, Taylor JR Tags: Am J Clin Pathol Source Type: research

The Next Chapter in Patient Blood Management: Real-Time Clinical Decision Support.
CONCLUSIONS: We have been able to significantly reduce inappropriate blood transfusions and related costs through an educational initiative coupled with real-time CDS. In deriving increased value out of health care, CDS can be applied to a number of overuse measures in laboratory testing, radiology, and therapy such as antibiotics, as outlined by the American Board of Internal Medicine's Choosing Wisely campaign. PMID: 25389326 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Goodnough LT, Shah N Tags: Am J Clin Pathol Source Type: research

Longitudinal engagement of pathology residents: a proposed approach for informatics training.
CONCLUSIONS: In transforming the ways in which pathology residencies teach their trainees informatics, the prospects of realizing its potential utility are heightened. PMID: 25389327 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Rao LK, Gilbertson JR Tags: Am J Clin Pathol Source Type: research

HER2 Heterogeneity Affects Trastuzumab Responses and Survival in Patients With HER2-Positive Metastatic Breast Cancer.
CONCLUSIONS: These results suggest that accurate assessment of HER2 status, including HER2 heterogeneity, is important in predicting trastuzumab responses and outcomes in patients with HER2-positive metastatic breast cancer. PMID: 25389328 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Lee HJ, Seo AN, Kim EJ, Jang MH, Suh KJ, Ryu HS, Kim YJ, Kim JH, Im SA, Gong G, Jung KH, Park IA, Park SY Tags: Am J Clin Pathol Source Type: research

p16INK4a Immunohistochemistry in Cervical Biopsy Specimens: A Systematic Review and Meta-Analysis of the Interobserver Agreement.
CONCLUSIONS: The published literature indicates improved interobserver agreement of the diagnosis of CIN2+ with the conjunctive use of H&E morphology with p16(INK4a) immunohistochemistry compared with H&E morphology alone. PMID: 25389329 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Reuschenbach M, Wentzensen N, Dijkstra MG, von Knebel Doeberitz M, Arbyn M Tags: Am J Clin Pathol Source Type: research

Cancer tracking: clinician compliance and program outcome.
CONCLUSIONS: Confirmation that the physician caring for a patient receives a pathology diagnosis is important for patient management and quality assurance. While the surgical pathology report was placed in the chart, it was impossible to confirm that the responsible physician had reviewed the report in 9% of cases. Techniques for communication and confirmation of transmission of anatomic pathology diagnoses need to be developed. PMID: 25389330 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Layfield LJ, Schnabel JL Tags: Am J Clin Pathol Source Type: research

Development and validation of effective real-time and periodic interinstrument comparison method for automatic hematology analyzers.
CONCLUSIONS: The 99th percentile CV cutoff value-derived daily acceptable ranges can be used as a real-time interinstrument comparison method in both patient samples and QC materials. Applying 4 SD as an ATE value can significantly reduce unnecessarily followed recalibration in the leukocyte differential counts, reticulocytes, and mean corpuscular volume. PMID: 25389331 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Park SH, Park CJ, Kim MJ, Choi MO, Han MY, Cho YU, Jang S Tags: Am J Clin Pathol Source Type: research

Epstein-barr virus-positive pleural effusion: clinical features, cytomorphologic characteristics, and flow cytometric immunophenotyping.
CONCLUSIONS: EBV infection/reactivation can account for certain proportions of "idiopathic" PEs. Polymorphous lymphocytosis is the most common cytologic feature, but atypical features (in both lymphocytes and mesothelial cells) can be seen. PMID: 25389332 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Takei H, Mody D Tags: Am J Clin Pathol Source Type: research

Mesenchymal stromal cell density is increased in higher grade myelodysplastic syndromes and independently predicts survival.
CONCLUSIONS: High CD271+ MSC density is characteristic of higher grade MDS and is associated with poor risk independent of known prognostic factors. PMID: 25389333 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Johnson RC, Kurzer JH, Greenberg PL, Gratzinger D Tags: Am J Clin Pathol Source Type: research

Mixed phenotype acute leukemia: a study of 61 cases using world health organization and European group for the immunological classification of leukaemias criteria.
CONCLUSIONS: As defined by the 2008 WHO classification, fewer patients are now classified as having MPAL than with the EGIL criteria. In this study, patients with MPAL have a better clinical outcome compared with patients with AML. PMID: 25389334 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Weinberg OK, Seetharam M, Ren L, Alizadeh A, Arber DA Tags: Am J Clin Pathol Source Type: research

Circulating donor-specific anti-human leukocyte antigen antibodies and complement c4d deposition are associated with the development of cardiac allograft vasculopathy.
CONCLUSIONS: Compared with the general HTR population, patients with graft dysfunction and DSA or positive C4d on EMB show a statistically significant increased incidence of CAV and allograft failure, suggesting an antibody-mediated injury. The presence of pre- and posttransplant DSA, even in the absence of positive C4d immunofluorescence, may identify a group of HTRs at increased risk of developing CAV. PMID: 25389335 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Frank R, Molina MR, Goldberg LR, Wald JW, Kamoun M, Lal P Tags: Am J Clin Pathol Source Type: research

Diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems.
CONCLUSIONS: HHV8-associated lymphomas can be clinically and pathologically heterogeneous, with features that may lead to misdiagnosis as other types of lymphoma. PMID: 25389336 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Courville EL, Sohani AR, Hasserjian RP, Zukerberg LR, Harris NL, Ferry JA Tags: Am J Clin Pathol Source Type: research

The lung-restricted marker napsin a is highly expressed in clear cell carcinomas of the ovary.
CONCLUSIONS: Our study showed that napsin A is an extremely sensitive (100%) marker of ovarian clear cell carcinomas and exhibits very high specificity (100%) in distinguishing clear cell carcinomas from high-grade serous carcinomas and serous borderline tumors and 90% specificity in discriminating clear cell carcinomas from endometrioid carcinomas. PMID: 25389337 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Kandalaft PL, Gown AM, Isacson C Tags: Am J Clin Pathol Source Type: research

Differential Expression of CD200 in B-Cell Neoplasms by Flow Cytometry Can Assist in Diagnosis, Subclassification, and Bone Marrow Staging.
CONCLUSIONS: CD200 staining by flow cytometry can be useful in the differential diagnosis of B-cell neoplasms and in their detection in the BM. PMID: 25389338 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Challagundla P, Medeiros LJ, Kanagal-Shamanna R, Miranda RN, Jorgensen JL Tags: Am J Clin Pathol Source Type: research

Prognostic stratification of ulcerated melanoma: not only the extent matters.
CONCLUSION: The extent and type of ulceration and involvement of the surrounding epidermis provided more accurate prognostic information than the mere absence or presence and may be useful markers allowing better stratification of ulcerated lesions. PMID: 25389339 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Bønnelykke-Behrndtz ML, Schmidt H, Christensen IJ, Damsgaard TE, Møller HJ, Bastholt L, Nørgaard PH, Steiniche T Tags: Am J Clin Pathol Source Type: research

Method Precision and Frequent Causes of Errors Observed in Point-of-Care Glucose Testing: A Proficiency Testing Program Perspective.
CONCLUSIONS: Both method CVs and error rates were higher in POC than in laboratory glucose methods, even though larger performance limits were used for the assessment of POC glucose. PMID: 25389340 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Aslan B, Stemp J, Yip P, Gun-Munro J Tags: Am J Clin Pathol Source Type: research

Uroplakin II Is a More Sensitive Immunohistochemical Marker Than Uroplakin III in Urothelial Carcinoma and Its Variants.
CONCLUSIONS: UPII demonstrates a significantly higher sensitivity than UPIII in conventional and variant UCs. Thus, UPII is a more valuable marker than UPIII in immunohistochemical analyses for confirming the urothelial origin of carcinomas. PMID: 25389341 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Li W, Liang Y, Deavers MT, Kamat AM, Matin SF, Dinney CP, Czerniak B, Guo CC Tags: Am J Clin Pathol Source Type: research

Analysis of preanalytical nonconformance in a medium-sized private pathology laboratory.
CONCLUSIONS: This is one of few studies of preanalytical nonconformance in a medium-sized private laboratory setting. Monitoring nonconformance for a pathology laboratory is essential to determine areas where further improvements can be made. PMID: 25389342 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Rana M, Naing K, Bothman J Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25389343 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Tags: Am J Clin Pathol Source Type: research

More accurate ways to measure tumor cellularity.
PMID: 25389344 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: True LD, Patel KP Tags: Am J Clin Pathol Source Type: research

An alternative approach to autopsy education and training: changing of the guard.
PMID: 25319969 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

Point-of-Care Testing: Is Faster Better?
PMID: 25319970 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Rainey PM, Ulibarri M Tags: Am J Clin Pathol Source Type: research

Valuing value: the changing role of pathologists.
PMID: 25319971 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Misialek MJ Tags: Am J Clin Pathol Source Type: research

The eAutopsy: An Effective Virtual Tool for Exposing Medical Students to the Postmortem Examination.
CONCLUSIONS: The two forms of autopsy exposure performed similarly on a Likert-type survey assessing certain attitudes related to the procedure. However, the emotional impact of the live experience may be longer lasting. PMID: 25319973 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Talmon GA, Czarnecki D, Bernal K Tags: Am J Clin Pathol Source Type: research

Blastomycosis of bone: a clinicopathologic study.
CONCLUSION: Blastomycosis osteomyelitis should be considered in the differential diagnosis of bone tumor, particularly when there is history of residence or travel in endemic areas. This disease can be correctly identified at frozen section, thus offering rapid diagnosis. There is an excellent correlation between morphologic and microbiologic studies. PMID: 25319975 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Jain R, Singh K, Lamzabi I, Harbhajanka A, Gattuso P, Reddy VB Tags: Am J Clin Pathol Source Type: research

Establishing an evidence base for critical laboratory value thresholds.
CONCLUSIONS: Only a subset of laboratory critical value thresholds was optimally chosen for increased risk of in-hospital mortality, with a time urgency for most but not all critical values. For many tests, a prior hospital admission imparted a decreased risk of in-hospital death. PMID: 25319976 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Doering TA, Plapp F, Crawford JM Tags: Am J Clin Pathol Source Type: research

Canadian Association of Pathologists-Association canadienne des pathologistes National Standards Committee for High Complexity Testing/Immunohistochemistry: Guidelines for the Preparation, Release, and Storage of Unstained Archived Diagnostic Tissue Sections for Immunohistochemistry.
CONCLUSIONS: Clear communication between requesting and releasing laboratories will facilitate the proper preparation of unstained sections and also ensure that applicable privacy considerations are addressed. PMID: 25319977 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Cheung CC, Banerjee D, Barnes PJ, Berendt RC, Butany J, Canil S, Clarke BA, El-Zimaity H, Garratt J, Geldenhuys L, Gilks CB, Manning L, Mengel M, Perez-Ordonez B, Pilavdzic D, Riddell R, Swanson PE, Torlakovic EE Tags: Am J Clin Pathol Source Type: research

Low Frequency of HNPCC-Associated Microsatellite Instability and Aberrant MMR Protein Expression in Early-Onset Bladder Cancer.
CONCLUSIONS: In young patients with bladder tumors, MSI and defects in MMR protein expression were not more frequent than in a series of consecutive bladder tumors. Most bladder tumors in young patients are not to be attributed to Lynch syndrome. PMID: 25319978 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Giedl J, Schneckenpointner R, Filbeck T, Ruemmele P, Hofstaedter F, Burger M, Hartmann A, Stoehr R Tags: Am J Clin Pathol Source Type: research

Implementation of Point-of-Care Testing in an Ambulatory Practice of an Academic Medical Center.
CONCLUSIONS: POCT can significantly improve clinical operations with cost reductions through improved practice efficiency. PMID: 25319979 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Crocker JB, Lee-Lewandrowski E, Lewandrowski N, Baron J, Gregory K, Lewandrowski K Tags: Am J Clin Pathol Source Type: research

Reference range determination for whole-blood platelet aggregation using the multiplate analyzer.
CONCLUSIONS: These data demonstrate the importance of establishing locally relevant reference ranges. PMID: 25319980 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Peerschke EI, Castellone DD, Stroobants AK, Francis J Tags: Am J Clin Pathol Source Type: research

Derivation of Pediatric Within-Individual Biological Variation by Indirect Sampling Method: An LMS Approach.
CONCLUSIONS: The median CVi derived from patients with only two repeat biochemistry measurements may be considered reasonable estimates of CVi among children seeking treatment at primary care settings. The LMS approach allowed visualization of the continuous trends of CVi with age and extended the pediatric CVi estimation to younger than 4 years. PMID: 25319981 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Loh TP, Ranieri E, Metz MP Tags: Am J Clin Pathol Source Type: research

Improved Survival in p16-Positive Vaginal Cancers Across All Tumor Stages but No Correlation With MIB-1.
CONCLUSIONS: The p16 marker has a significant prognostic impact in primary squamous cell vaginal cancers across all tumor stages. PMID: 25319982 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Feldbaum VM, Flowers LC, Oprea-Ilies GM Tags: Am J Clin Pathol Source Type: research

Medullary-like hepatocellular carcinoma: an unusual histologic variant.
CONCLUSIONS: This report is presented to increase awareness of this unusual lesion and because it raises questions regarding the previous claim suggesting a less aggressive clinical course. PMID: 25319983 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Quist E, Talmon G, Hartman C, Wisecarver J Tags: Am J Clin Pathol Source Type: research

Myoid gonadal stromal tumor: a clinicopathologic study of three cases of a distinctive testicular tumor.
CONCLUSIONS: Myoid gonadal stromal tumors are small (<4 cm) indolent testicular tumors distinctly different from other sex cord-stromal tumors and are adequately managed by orchiectomy. PMID: 25319984 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Kao CS, Ulbright TM Tags: Am J Clin Pathol Source Type: research

Primary intrathymic lymphangioma.
CONCLUSIONS: Intrathymic lymphangioma should always be taken into consideration in the differential diagnosis of cystic mediastinal lesions in children and adult patients. PMID: 25319985 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Licci S, Puma F, Sbaraglia M, Ascani S Tags: Am J Clin Pathol Source Type: research

Pseudoinsulinoma in a white man with autoimmune hypoglycemia due to anti-insulin antibodies: value of the free C-Peptide assay.
CONCLUSIONS: In patients presenting with hypoglycemia with excessively high insulin levels, consideration needs to be given to autoimmune hypoglycemia due to anti-insulin antibodies as a cause. Additionally, if total C-peptide levels are increased, free C-peptide needs to be quantitated following polyethylene glycol precipitation. PMID: 25319986 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Arzamendi AE, Rajamani U, Jialal I Tags: Am J Clin Pathol Source Type: research

Benign Atypical Intravascular CD30+ T-Cell Proliferation: A Recently Described Reactive Lymphoproliferative Process and Simulator of Intravascular Lymphoma: Report of a Case Associated With Lichen Sclerosus and Review of the Literature.
CONCLUSIONS: This benign cutaneous lymphoproliferation needs to be distinguished from intravascular T-cell lymphoma, particularly from the intravascular variant of anaplastic large cell lymphoma. Obstruction of lymphatics due to lichen sclerosus with disrupted immune cell trafficking may result in the accumulation of activated CD30+ lymphocytes. PMID: 25319987 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Kempf W, Keller K, John H, Dommann-Scherrer C Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25319988 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Media Review.
PMID: 25319989 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 21, 2014 Category: Pathology Authors: Hoda SA Tags: Am J Clin Pathol Source Type: research

When the rubber meets the road: dealing with a returning traveler from west Africa during the ebola outbreak of 2014.
PMID: 25239405 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Guarner J Tags: Am J Clin Pathol Source Type: research

Resident training in new technologies.
PMID: 25239406 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

IgG4+ Plasma Cells in Isolated Reactive Lymphadenopathy.
PMID: 25239407 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Cotta CV, Hsi ED Tags: Am J Clin Pathol Source Type: research

Cancer in low- and middle-income countries: where to start? Is it pathology?
PMID: 25239408 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Guarner J, Fleming K Tags: Am J Clin Pathol Source Type: research

Clinical Laboratory Immunology: An Indispensable Player in Laboratory Medicine.
CONCLUSIONS: It is anticipated that sharing this knowledge will increase awareness of the discipline of clinical laboratory immunology at the postdoctoral level with implications for the practice of laboratory medicine. PMID: 25239409 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Tebo AE, Detrick B, Hamilton RG, Khanolkar A, O'Gorman MR, Schmitz JL, Abraham RS Tags: Am J Clin Pathol Source Type: research

The current state of resident training in genomic pathology: a comprehensive analysis using the resident in-service examination.
CONCLUSIONS: The RISE is a powerful tool for assessing the state of resident training in genomic pathology and current results suggest a significant deficit. The results also provide a baseline to assess future initiatives to improve genomics education for pathology residents such as those developed by the TRIG Working Group. PMID: 25239410 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Haspel RL, Rinder HM, Frank KM, Wagner J, Ali AM, Fisher PB, Parks ER, Training Residents in Genomics (TRIG) Working Group Tags: Am J Clin Pathol Source Type: research

CD8+ Lymphocyte Intratumoral Infiltration as a Stage-Independent Predictor of Merkel Cell Carcinoma Survival: A Population-Based Study.
CONCLUSIONS: This study of prospectively captured MCC cases supports the concept that cellular immunity is important in MCC outcome and that CD8+ lymphocyte infiltration adds prognostic information to conventional staging. PMID: 25239411 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Paulson KG, Iyer JG, Simonson WT, Blom A, Thibodeau RM, Schmidt M, Pietromonaco S, Sokil M, Warton EM, Asgari MM, Nghiem P Tags: Am J Clin Pathol Source Type: research

Abundance of IgG4+ Plasma Cells in Isolated Reactive Lymphadenopathy Is No Indication of IgG4-Related Disease.
CONCLUSION: Without a clinical suspicion of IgG4-related disease, these morphologic patterns and high numbers of IgG4-positive plasma cells should be interpreted with care to avoid an erroneous diagnosis of IgG4-related disease. PMID: 25239412 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: Martinez LL, Friedländer E, van der Laak JA, Hebeda KM Tags: Am J Clin Pathol Source Type: research

Utility of measurement of interleukin-1ß and interleukin-8 in the diagnosis of complicated parapneumonic pleural effusions.
CONCLUSIONS: Measurement of IL-1β and IL-8 in pleural fluid may be useful in the early diagnosis of CPPE, although individually, it may not improve the results obtained with the PFLD. Further studies are needed to more firmly establish what role these new parameters can play in the diagnosis of CPPE. PMID: 25239413 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2014 Category: Pathology Authors: San José ME, Ferreiro L, Soneira ME, González-Barcala FJ, Vázquez MC, Golpe A, Valdés L Tags: Am J Clin Pathol Source Type: research