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Laboratory Medicine and Value-Based Health Care.
PMID: 26276766 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Schmidt RL, Ashwood ER Tags: Am J Clin Pathol Source Type: research

The Persistence of Misinformation.
PMID: 26276767 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

Acute Leukemias of Ambiguous Origin.
CONCLUSIONS: There was an agreement that diagnosis of MPAL can be challenging, especially if applied flow cytometry panels are not comprehensive enough. PMID: 26276768 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Porwit A, Béné MC Tags: Am J Clin Pathol Source Type: research

Hematolymphoid Neoplasms Associated With Rearrangements of PDGFRA, PDGFRB, and FGFR1.
CONCLUSIONS: Early recognition of these neoplasms is important because patients with neoplasms associated with PDGFRA or PDGFRB fusions often respond to tyrosine kinase inhibitor therapy, whereas patients with neoplasms associated with FGFR1 fusions usually do not respond. PMID: 26276769 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Vega F, Medeiros LJ, Bueso-Ramos CE, Arboleda P, Miranda RN Tags: Am J Clin Pathol Source Type: research

B-Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.
CONCLUSIONS: The complexity and spectrum of cases presented in this review highlight the importance of clinicopathologic correlation and the value of ancillary studies in the classification and workup of patients with B-ALL/LBL. PMID: 26276770 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Loghavi S, Kutok JL, Jorgensen JL Tags: Am J Clin Pathol Source Type: research

T-Lymphoblastic Leukemia/Lymphoma.
CONCLUSIONS: In view of the growing importance of molecular genetic analysis in the diagnosis and prognosis of T-ALL/T-LBL, it is important for pathologists to keep abreast of these developments. Currently, routine histopathology, immunophenotyping, conventional cytogenetic analysis, fluorescence in situ hybridization, and clonality testing are usually adequate to establish the diagnosis. However, as therapies become more targeted, assessment for relevant genetic abnormalities, either through candidate gene or broad-scale unbiased approaches, may become necessary. PMID: 26276771 [PubMed - in process] (Source: American ...
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: You MJ, Medeiros LJ, Hsi ED Tags: Am J Clin Pathol Source Type: research

Limiting the Testing of AST: A Diagnostically Nonspecific Enzyme.
CONCLUSIONS: Conservatively, $100 million could be saved annually in the US health care budget by selectively limiting AST testing in just the US outpatient environment. PMID: 26276772 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Xu Q, Higgins T, Cembrowski GS Tags: Am J Clin Pathol Source Type: research

Calciphylaxis and the Persistence of Medical Misinformation in the Era of Google.
CONCLUSIONS: Medical misinformation such as this is frequently perpetuated. We propose that computational resources could be better used to flag erroneous and contradicted claims to update and correct the literature. PMID: 26276773 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Granter SR, Laga AC, Larson AR Tags: Am J Clin Pathol Source Type: research

The American Society for Clinical Pathology's 2014 Vacancy Survey of Medical Laboratories in the United States.
CONCLUSIONS: Factors such as retirement and the improving economy are driving the need for more laboratory professionals. Recruitment of qualified laboratory professionals in the workforce and students in laboratory programs will be the key in fulfilling the higher vacancies revealed from the survey results in 2014. PMID: 26276774 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Garcia E, Ali AM, Soles RM, Lewis DG Tags: Am J Clin Pathol Source Type: research

Evaluating the Utility of Trefoil Factor 1 as a Mammary-Specific Immunostain Compared and in Conjunction With GATA-3 and Mammaglobin in the Distinction Between Carcinoma of Breast and Lung.
CONCLUSIONS: TFF1 demonstrated breast specificity but was inferior to mammaglobin and GATA-3. Therefore, its routine clinical use may not be justified. TFF1 showed little benefit when added to an immunopanel. PMID: 26276775 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Wells JM, Ginter PS, Liu Y, Chen Z, Narula N, Shin SJ Tags: Am J Clin Pathol Source Type: research

Distinct β-Catenin and PIK3CA Mutation Profiles in Endometriosis-Associated Ovarian Endometrioid and Clear Cell Carcinomas.
CONCLUSIONS: Distinct molecular events may occur in relatively early stages of tumorigenesis of endometriosis-associated OEMCas and OCCCas. PMID: 26276776 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Matsumoto T, Yamazaki M, Takahashi H, Kajita S, Suzuki E, Tsuruta T, Saegusa M Tags: Am J Clin Pathol Source Type: research

Probabilistic Issues With Sentinel Lymph Nodes in Malignant Melanoma.
CONCLUSIONS: Probability analyses provide useful insight into the success and failure of the sentinel node biopsy procedure in patients with melanoma. PMID: 26276777 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Vollmer RT Tags: Am J Clin Pathol Source Type: research

Human Papillomavirus Oncogenic mRNA Testing for Cervical Cancer Screening: Baseline and Longitudinal Results From the CLEAR Study.
CONCLUSIONS: These results support the use of AHPV as a safe and effective adjunctive cervical cancer screening method. PMID: 26276778 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Reid JL, Wright TC, Stoler MH, Cuzick J, Castle PE, Dockter J, Getman D, Giachetti C Tags: Am J Clin Pathol Source Type: research

Complex Measurements May Be Required to Establish the Prognostic Impact of Immunophenotypic Markers in AML.
CONCLUSIONS: CD34 positivity threshold with prognostic relevance is low (3% positive cells). Immunophenotypic findings in AML probably could only be fully exploited after a complex analysis that takes into account unconventional thresholds and the MFI. PMID: 26276779 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: García-Dabrio MC, Hoyos M, Brunet S, Tormo M, Ribera JM, Esteve J, Gallardo D, Duarte RF, de Llano MP, Bargay J, Martí-Tutusaus JM, Heras I, Garcia A, Salamero O, Aventin A, Lecrevisse Q, Orfao A, Sierra J, Nomdedéu JF Tags: Am J Clin Pathol Source Type: research

Morphologically Occult Systemic Mastocytosis in Bone Marrow: Clinicopathologic Features and an Algorithmic Approach to Diagnosis.
CONCLUSIONS: Morphologically occult involvement of normal-appearing BM by SM will be missed without appropriate clinical suspicion and pathologic evaluation by tryptase and CD25 IHC and KIT D816V mutation analysis. On the basis of these findings, we propose a cost-effective, data-driven, evidence-based algorithmic approach to the workup of these cases. PMID: 26276780 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Reichard KK, Chen D, Pardanani A, McClure RF, Howard MT, Kurtin PJ, Wood AJ, Ketterling RP, King RL, He R, Morice WG, Hanson CA Tags: Am J Clin Pathol Source Type: research

Polypoid Laryngeal Inflammatory Myofibroblastic Tumors: Misleading Lesions: Description of Six Cases Showing ALK Overexpression.
CONCLUSIONS: According to our series, laryngeal IMTs are easily misdiagnosed. They have a good prognosis, and ALK immunohistochemistry should be carried out to assess this diagnosis when spindle cell proliferations are observed in this localization. PMID: 26276782 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Pierry C, Pérot G, Karanian-Philippe M, Neuville A, Gomez-Brouchet A, Crestani S, Coindre JM Tags: Am J Clin Pathol Source Type: research

Computer-Aided Detection of Rare Tumor Populations in Flow Cytometry: An Example With Classic Hodgkin Lymphoma.
CONCLUSIONS: All classifiers provide probabilistic confidences for each result, and diagnostic cutoffs can be chosen to minimize false negatives and serve as a screening tool. Computational exclusion of manually gated HRS cells had little impact on the overall performance of selected support vectors in SVM or dimensionality reduction, suggesting that features of the immune response in cHL may dictate the method accuracy. We hypothesize there are distinct inflammatory cells that suggest cHL. PMID: 26276783 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Ng DP, Wu D, Wood BL, Fromm JR Tags: Am J Clin Pathol Source Type: research

Resident Remediation: Start From Scratch.
PMID: 26276784 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Barnhoorn PC, Domen RE Tags: Am J Clin Pathol Source Type: research

Reference Intervals Data Mining: Getting the Right Paper.
PMID: 26276785 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Jones G, Horowitz G, Katayev A, Fleming JK, Luo D, Fisher AH, Sharp TM Tags: Am J Clin Pathol Source Type: research

Is "Polysomy" in Breast Carcinoma the "New Equivocal" in HER2 Testing?
PMID: 26185303 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Swanson PE, Yang H Tags: Am J Clin Pathol Source Type: research

Importance of Fungal Histopathology in Immunocompromised Pediatric Patients: It's Not Just "Aspergillus" Anymore.
PMID: 26185304 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Schuetz AN, Walsh TJ Tags: Am J Clin Pathol Source Type: research

Acute Myeloid Leukemia and Other Types of Disease Progression in Myeloproliferative Neoplasms.
CONCLUSIONS: There was agreement that a definitive diagnosis can be challenging in the absence of documented review of prior diagnostic material and clinical history. PMID: 26185305 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Czader M, Orazi A Tags: Am J Clin Pathol Source Type: research

Therapy-Related Myeloid Neoplasms.
CONCLUSIONS: The study of TR-MNs will likely provide insight into the pathogenesis of de novo myeloid disease and may explain why some patients with cancer develop TR-MN and evidently have a higher genetic susceptibility, whereas most patients treated with the same agents do not. These studies will also result in critical reappraisal of current concepts related to TR-MNs. PMID: 26185306 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA Tags: Am J Clin Pathol Source Type: research

Extramedullary Manifestations of Myeloid Neoplasms.
CONCLUSIONS: In the era of targeted therapy and sophisticated risk stratification, every attempt must be made to perform a complete workup on MS cases (or concurrent AML) since the diagnosis of MS, in itself, is no longer adequate for patient management. Cases of blastic plasmacytoid dendritic cell neoplasm were also included and discussed in this session. PMID: 26185307 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Wilson CS, Medeiros LJ Tags: Am J Clin Pathol Source Type: research

Performance of a Tuberculosis Serologic Assay in Various Patient Populations.
CONCLUSIONS: This study confirmed the limitations of serodiagnosis for active tuberculosis, including poor sensitivity and increased reactivity with nontuberculous mycobacterium-positive patients. PMID: 26185308 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: She RC, Litwin CM Tags: Am J Clin Pathol Source Type: research

Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients.
CONCLUSIONS: CGAT was critical in the genotype clarification of these cases through detection of copy-neutral loss of heterozygosity and should be considered performing for B-ALL with apparent hyperdiploidy for accurate prognostic risk stratification and treatment planning. PMID: 26185311 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Fang M, Becker PS, Linenberger M, Eaton KD, Appelbaum FR, Dreyer Z, Airewele G, Redell M, Lopez-Terrada D, Patel A, Rabin KR, Lu X Tags: Am J Clin Pathol Source Type: research

Disparities in Interpretation of Primary Testicular Germ Cell Tumor Pathology.
CONCLUSIONS: Inaccurate interpretation of orchiectomy specimens is not uncommon and may lead to incorrect tumor staging, imprecise assignment of progression risk, and inappropriate management recommendations. Secondary opinions of primary GCT orchiectomy specimens potentially facilitate appropriate counseling and therapeutic strategies. PMID: 26185314 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Sharma P, Dhillon J, Agarwal G, Zargar-Shoshtari K, Sexton WJ Tags: Am J Clin Pathol Source Type: research

Cytoplasmic 5-Lipoxygenase Staining Is a Highly Sensitive Marker of Human Tumors of the Choroid Plexus.
CONCLUSIONS: Our findings indicate that cytoplasmic 5-LO immunoreactivity is highly characteristic of human choroid plexus tumors but not other central nervous system tumor types. Cytoplasmic staining for 5-LO may prove to be a useful immunoreactive marker in the diagnosis of choroid plexus tumors. PMID: 26185315 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Xingfu W, Lifeng Z, Yupeng C, Xueyong L, Wei L, Yinghao Y, Suqin C, Mi W, Sheng Z Tags: Am J Clin Pathol Source Type: research

Heterogeneity of Abnormal RUNX1 Leading to Clinicopathologic Variations in Childhood B-Lymphoblastic Leukemia.
CONCLUSIONS: RUNX1 copy numbers seem to be proportional to the age of B-ALL onset and the frequency of CSF involvement, while RUNX1 amplification vs translocation causes aberrant expression of CD7 and CD13, respectively. PMID: 26185316 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Knez VM, Carstens BJ, Swisshelm KL, McGranahan AN, Liang X Tags: Am J Clin Pathol Source Type: research

Attitudes, Practices, and Training on Informed Consent for Transfusions and Procedures: A Survey of Medical Students and Physicians.
CONCLUSIONS: Only 60% of respondents felt their informed consent training was adequate. Multiple areas of difficulty in obtaining proper informed consent were identified that should be addressed with focused training or written guidelines. PMID: 26185317 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Vossoughi SR, Macauley R, Sazama K, Fung MK Tags: Am J Clin Pathol Source Type: research

Thyroid Pathology Findings in Cowden Syndrome: A Clue for the Diagnosis of the PTEN Hamartoma Tumor Syndrome.
CONCLUSIONS: Pathologists play a crucial role in recognizing pathologic thyroid findings associated with PHTS for selecting patients for genetic testing. PMID: 26185318 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Cameselle-Teijeiro J, Fachal C, Cabezas-Agrícola JM, Alfonsín-Barreiro N, Abdulkader I, Vega-Gliemmo A, Hermo JA Tags: Am J Clin Pathol Source Type: research

Transiently Pink-Tinged Serum in a Patient With Multiple Myeloma and Anemia Undergoing Lenalidomide Treatment.
CONCLUSIONS: Upon administration, chemotherapeutic agents, such as lenalidomide, can immediately induce transient hemolysis, which can be visualized as transiently pink-tinged serum samples. PMID: 26185319 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Wedel W, Sofronescu AG Tags: Am J Clin Pathol Source Type: research

B-Lymphoblastic Leukemia in Patients With Chronic Lymphocytic Leukemia: A Report of Four Cases.
CONCLUSIONS: Our data suggest that at least some cases of B-LBL arising in patients with CLL are independent, secondary neoplasms rather than a manifestation of histologic transformation. PMID: 26185320 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Chakhachiro Z, Yin CC, Abruzzo LV, Aladily TN, Barron LL, Banks HE, Thomas DA, Keating M, Medeiros LJ, Huh YO Tags: Am J Clin Pathol Source Type: research

Primary Marginal Zone Lymphoma of the Subcutis Associated With Panniculitis and Fat Necrosis.
CONCLUSIONS: This case represents, to our knowledge, the first reported case of primary subcutaneous B-cell lymphoma closely associated with panniculitis. PMID: 26185321 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Chui MH, Kukreti V, Wei C, Delabie J Tags: Am J Clin Pathol Source Type: research

Minimal Coexpression of CD34+/CD56+ in Acute Promyelocytic Leukemia Is Associated With Relapse.
CONCLUSIONS: This case report suggests that the presence of a clone with minimal coexpression of CD34/CD56 in APML at initial diagnosis should not be neglected since it may be associated with earlier relapse. PMID: 26185322 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Maenhout TM, Moreau E, Van Haute I, Desmet S, Deeren D Tags: Am J Clin Pathol Source Type: research

Introduction to the 2013 Workshop of the Society for Hematopathology/European Association for Haematopathology.
PMID: 26071457 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Bueso Ramos CE, Medeiros LJ, Vega-Vazquez F Tags: Am J Clin Pathol Source Type: research

Acute Myeloid Leukemia With Recurrent Cytogenetic Abnormalities.
CONCLUSIONS: This review focuses on providing updated recommendations for the rapid diagnosis of APL, discussing the types and significance of variant RARA mutations in APL-like leukemias, and refining low-blast-count (oligoblastic) AML. In addition, the significance of unique morphologic, immunophenotypic, and genetic variations in AML defined by a recurrent cytogenetic abnormality is included. PMID: 26071458 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Foucar K, Anastasi J Tags: Am J Clin Pathol Source Type: research

Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
CONCLUSIONS: In aggregate, this session highlighted the need for a refined molecular classification of AML as well as improved risk stratification based on systematic assessment for genetic alterations and their evolution over time. PMID: 26071459 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Lin P, Falini B Tags: Am J Clin Pathol Source Type: research

Acute Myeloid Leukemia With Myelodysplasia-Related Changes.
CONCLUSIONS: Whole-genome sequencing and array studies may identify genetic abnormalities, such as those affecting TP53, which may provide prognostic information. PMID: 26071460 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Vardiman J, Reichard K Tags: Am J Clin Pathol Source Type: research

Acute Erythroleukemias, Acute Megakaryoblastic Leukemias, and Reactive Mimics: A Guide to a Number of Perplexing Entities.
CONCLUSIONS: The broad spectrum of cases illustrated the difficulties and complex issues involved in establishing a diagnosis of these entities and the need for better disease definitions. PMID: 26071461 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Wang SA, Hasserjian RP Tags: Am J Clin Pathol Source Type: research

Positive Impact of Fungal Histopathology on Immunocompromised Pediatric Patients With Histology-Proven Invasive Fungal Infection.
CONCLUSIONS: Histology can provide rapid, accurate, and clinically actionable information to clinicians caring for children with IFI. PMID: 26071462 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Dekio F, Bhatti TR, Zhang SX, Sullivan KV Tags: Am J Clin Pathol Source Type: research

Comparative Analysis Reveals Potential Utility of Digital Microscopy in the Evaluation of Peripheral Blood Smears With Some Barriers to Implementation.
CONCLUSIONS: These results support the limited use of digital microscopy for evaluation and triage of peripheral blood smears as a practical option to obtain expert opinion in locations where experienced staff is not available on site. Our results indicate that while digital microscopy is well suited for basic triage of these blood smears, limitations in quality of imaging at higher magnification as well as large file size may limit its utility in certain settings and situations. PMID: 26071463 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Gomez-Gelvez JC, Kryvenko ON, Chabot-Richards DS, Foucar K, Inamdar KV, Karner KH Tags: Am J Clin Pathol Source Type: research

Isolated del(5q) in Patients Following Therapies for Various Malignancies May Not All Be Clinically Significant.
CONCLUSIONS: Development of del(5q) in patients following cytotoxic therapies or TKI may not always be associated with t-MN. A close follow-up seems an appropriate approach for patients who had a minor del(5q) clone. PMID: 26071464 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Tang G, Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, DiNardo C, Medeiros LJ Tags: Am J Clin Pathol Source Type: research

Immunohistochemistry for BRAF V600E in the Differential Diagnosis of Hairy Cell Leukemia vs Other Splenic B-Cell Lymphomas.
CONCLUSIONS: The detection of BRAF V600E by IHC is useful in the distinction of HCLs from other splenic-based lymphomas, although the identification of at least rare SMZLs containing this abnormality illustrates the continuing need for a multiparameter approach to diagnosis. PMID: 26071465 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Turakhia S, Lanigan C, Hamadeh F, Swerdlow SH, Tubbs RR, Cook JR Tags: Am J Clin Pathol Source Type: research

Neutropenia in Congenital and Adult Babesiosis.
CONCLUSIONS: Neutropenia appears to be a common finding in infants with congenital babesiosis and is also observed not infrequently in adults with this infection. PMID: 26071466 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Wormser GP, Villafuerte P, Nolan SM, Wang G, Lerner RG, Saetre KL, Maria MH, Branda JA Tags: Am J Clin Pathol Source Type: research

Yearly Clinical Laboratory Test Expenditures for Different Medical Specialties in a Major Canadian City.
CONCLUSIONS: There was wide variation in clinical laboratory test expenditures among specialties and on a per capita basis within medical specialties. PMID: 26071467 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Naugler C, Thomas R, Turin TC, Guo M, Vaska M, COAPT (Collaboration On Assessing Physician Testing) Tags: Am J Clin Pathol Source Type: research

Cytogenetic Variation of B-Lymphoblastic Leukemia With Intrachromosomal Amplification of Chromosome 21 (iAMP21): A Multi-Institutional Series Review.
CONCLUSIONS: Our findings not only demonstrate that B-ALL with iAMP21 is truly a distinct clinicopathologic entity but also suggest that a subset of cases of B-ALL with iAMP21 can show variable cytogenetic features. PMID: 26071468 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Johnson RC, Weinberg OK, Cascio MJ, Dahl GV, Mitton BA, Silverman LB, Cherry AM, Arber DA, Ohgami RS Tags: Am J Clin Pathol Source Type: research

Utility of Human Papillomavirus Capsid Protein L1 and p16 in the Assessment and Accurate Classification of Anal Squamous Intraepithelial Lesions.
CONCLUSIONS: HPV L1 and diffuse p16 expression is mutually exclusive in most anal SILs and helps separate LSIL and HSIL cases. Application of both HPV L1 and p16 can not only facilitate accurate grading but also contribute to risk assessment in anal neoplasia. PMID: 26071469 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Patil DT, Yang B Tags: Am J Clin Pathol Source Type: research

Daily Management System of the Henry Ford Production System: QTIPS to Focus Continuous Improvements at the Level of the Work.
CONCLUSIONS: Daily management is the key business accountability subsystem that enabled our culture of continuous improvement to function more efficiently at the managerial level in a visible manner by reviewing and acting based on data and root cause analysis. PMID: 26071470 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Zarbo RJ, Varney RC, Copeland JR, D'Angelo R, Sharma G Tags: Am J Clin Pathol Source Type: research

Spectrum of Clonal Large Granular Lymphocytes (LGLs) of αβ T Cells: T-Cell Clones of Undetermined Significance, T-Cell LGL Leukemias, and T-Cell Immunoclones.
CONCLUSIONS: Most of the LGLT clones detected by flow cytometry were small and did not change the clinical management. We propose the following terminology: T-cell clones of undetermined significance, LGLT leukemias, and T-cell immunoclones. PMID: 26071471 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Singleton TP, Yin B, Teferra A, Mao JZ Tags: Am J Clin Pathol Source Type: research