American Journal of Clinical Pathology American Journal of Clinical Pathology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the latest items in this publication.

Expression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms:  A Potential Diagnostic Pitfall.
CONCLUSIONS: Hepatocellular differentiation markers, including albumin mRNA ISH, may be positive in ACC, but arginase 1 appears to be uniformly negative. Thus, its use may improve the accuracy in distinguishing these neoplasms from hepatocellular carcinoma. If ACC diagnosis is considered, acinar differentiation can be reliably demonstrated by trypsin/chymotrypsin. PMID: 27425386 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 17, 2016 Category: Pathology Authors: Askan G, Deshpande V, Klimstra DS, Adsay V, Sigel C, Shia J, Basturk O Tags: Am J Clin Pathol Source Type: research

Pathology of Chronic Chagas Cardiomyopathy in the United States:  A Detailed Review of 13 Cardiectomy Cases.
CONCLUSIONS: The gross and microscopic features of chronic Chagas cardiomyopathy in the United States appear similar to those reported in endemic countries. Importantly, tissue polymerase chain reaction may be useful to confirm the diagnosis. PMID: 27425387 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 17, 2016 Category: Pathology Authors: Kransdorf EP, Fishbein MC, Czer LS, Patel JK, Velleca A, Tazelaar HD, Roy RR, Steidley DE, Kobashigawa JA, Luthringer DJ Tags: Am J Clin Pathol Source Type: research

Immunophenotypes of Chronic Myelomonocytic Leukemia (CMML) Subtypes by Flow Cytometry:  A Comparison of CMML-1 vs CMML-2, Myeloproliferative vs Dysplastic, De Novo vs Therapy-Related, and CMML-Specific Cytogenetic Risk Subtypes.
CONCLUSIONS: These findings confirm heterogeneity within CMML subgroups and find no specific qualitative or quantitative findings characteristic of a subgroup. PMID: 27413139 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 13, 2016 Category: Pathology Authors: Harrington AM, Schelling LA, Ordobazari A, Olteanu H, Hosking PR, Kroft SH Tags: Am J Clin Pathol Source Type: research

Sentinel Lymph Node Frozen-Section Utilization Declines After Publication of American College of Surgeons Oncology Group Z0011 Trial Results With No Change in Subsequent Surgery for Axillary Lymph Node Dissection.
CONCLUSIONS: Our findings support reduced need for SLN FS for BCT patients post-Z0011. However, those with specific clinicopathologic features may derive greater benefit from SLN FS. PMID: 27373347 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 3, 2016 Category: Pathology Authors: Jorns JM, Kidwell KM Tags: Am J Clin Pathol Source Type: research

Vaginal Cytology Results in Follow-up of Endometrial Carcinoma After Hysterectomy.
CONCLUSIONS: Vaginal recurrences of EmCa were diagnosed in 11 (2.6%) of 420 patients with documented vaginal follow-up testing. Abnormal vaginal cytology findings directly led to vaginal biopsy diagnoses of EmCa in two of the 11 patients. Vaginal cytology is no longer a recommended routine surveillance option for detection of vaginal cuff recurrence of EmCa. PMID: 27371362 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 30, 2016 Category: Pathology Authors: Zhao C, Karunamurthy A, Jain S, Austin RM Tags: Am J Clin Pathol Source Type: research

Thymomas With Extensive Clear Cell Component:  A Clinicopathologic and Immunohistochemical Study of Nine Cases.
CONCLUSIONS: The cases herein presented highlight an unusual feature in thymoma that has more commonly been ascribed to thymic carcinoma. They also emphasize the importance of correct diagnosis to determine the appropriate treatment strategy and to accurately predict prognosis. PMID: 27371363 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 30, 2016 Category: Pathology Authors: Weissferdt A, Kalhor N, Moran CA Tags: Am J Clin Pathol Source Type: research

Discordant Mismatch Repair Protein Immunoreactivity in Lynch Syndrome-Associated Neoplasms: A Recommendation for Screening Synchronous/Metachronous Neoplasms.
CONCLUSIONS: LS diagnosis could have been missed in 31% of the study cases if only the LSAN exhibiting intact MMRP expression was screened. Accordingly, our findings support the recommendation to perform LS screening in all primary, synchronous, and metachronous intestinal and endometrial cancers if a previous tumor screened intact. PMID: 27357288 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Roth RM, Haraldsdottir S, Hampel H, Arnold CA, Frankel WL Tags: Am J Clin Pathol Source Type: research

Does Taking the Fellowship In-Service Hematopathology Examination and Performance Relate to Success on the American Board of Pathology Hematology Examination?
CONCLUSIONS: Candidates who take the spring FISHE do better on the ABP-HE than those who do not. Most fellows passed the first attempted ABP-HE regardless of FISHE performance. Whether this is due to fellows making use of the FISHE as a self-evaluation tool to help identify and then correct their knowledge deficiencies remains to be determined. PMID: 27357289 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Monaghan SA, Felgar RE, Kelly MA, Ali AM, Anastasi J, Bellara AP, Rinder HM, Sargent RL, Wagner J, Swerdlow SH, Johnson RL Tags: Am J Clin Pathol Source Type: research

Neonatal Intensive Care Unit Quality Initiative: Identifying Preanalytical Variables Contributing to Specimen Hemolysis and Measuring the Impact of Evidence-Based Practice Interventions.
CONCLUSIONS: We identified three variables contributing to hemolysis and instituted two clinical practice interventions to significantly reduce test cancellations due to hemolysis. PMID: 27357290 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Tolan NV, Kaleta EJ, Fang JL, Colby CE, Carey WA, Karon BS, Baumann NA Tags: Am J Clin Pathol Source Type: research

Evaluation of a Methotrexate Chemiluminescent Microparticle Immunoassay: Comparison to Fluorescence Polarization Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry.
CONCLUSIONS: These results comparing CMIA vs FPIA and LC-MS/MS indicate that CMIA is a suitable alternative to the FPIA method. PMID: 27357291 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Bouquié R, Grégoire M, Hernando H, Azoulay C, Dailly E, Monteil-Ganière C, Pineau A, Deslandes G, Jolliet P Tags: Am J Clin Pathol Source Type: research

Transportation Cooler Interventions Reduce Plasma and RBC Product Wastage.
CONCLUSIONS: Our intervention resulted in significantly decreased plasma and RBC wastage and is broadly applicable, since out-of-temperature product wastage in procedural areas is likely a significant problem at many institutions. PMID: 27357292 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Metcalf RA, Baker SA, Goodnough LT, Shah N Tags: Am J Clin Pathol Source Type: research

Evaluation of the Sebia Capillarys 3 Tera and the Bio-Rad D-100 Systems for the Measurement of Hemoglobin A1c.
CONCLUSIONS: The Bio-Rad D-100 and the Sebia Capillarys 3 Tera instruments performed well for the determination of HbA1c in terms of quality criteria as well as for sample throughput. PMID: 27357293 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Herpol M, Lanckmans K, Van Neyghem S, Clement P, Crevits S, De Crem K, Gorus FK, Weets I Tags: Am J Clin Pathol Source Type: research

Pathologic Studies of Fatal Encephalomyelitis in Children Caused by Enterovirus 71.
CONCLUSIONS: Our study revealed direct pathologic evidence supporting viral entry into the central nervous system (CNS) through peripheral nerves. In addition to the major motor pathway, EV71 can also enter the CNS via peripheral sensory and autonomic pathways in retrograde axonal transport. PMID: 27357294 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Xing J, Liu D, Shen S, Su Z, Zhang L, Duan Y, Tong F, Liang Y, Wang H, Deng F, Hu Z, Zhou Y Tags: Am J Clin Pathol Source Type: research

Comparison of Free Light Chain Assays: Freelite and N Latex in Diagnosis, Monitoring, and Predicting Survival in Light Chain Amyloidosis.
CONCLUSIONS: Both FLC assays show good correlation in detecting the abnormal light chain subtype with discordance in absolute values and thus are not interchangeable. PMID: 27353767 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 27, 2016 Category: Pathology Authors: Mahmood S, Wassef NL, Salter SJ, Sachchithanantham S, Lane T, Foard D, Whelan CJ, Lachmann HJ, Gillmore JD, Hawkins PN, Wechalekar AD Tags: Am J Clin Pathol Source Type: research

Bone Marrow Conventional Karyotyping and Fluorescence In Situ Hybridization: Defining an Effective Utilization Strategy for Evaluation of Myelodysplastic Syndromes.
CONCLUSIONS: In the evaluation of a possible MDS, FISH rarely provides additional value when karyotype is adequate. We propose a value-based, cost-effective algorithmic approach for conventional karyotyping and FISH testing in routine MDS workup. PMID: 27353768 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 27, 2016 Category: Pathology Authors: He R, Wiktor AE, Durnick DK, Kurtin PJ, Van Dyke DL, Tefferi A, Patnaik MS, Ketterling RP, Hanson CA Tags: Am J Clin Pathol Source Type: research

Touch Preps of Products of Conception for Rule-Out Ectopic Pregnancy: A Viable Alternative to Frozen Section.
CONCLUSIONS: POC can be diagnosed by touch prep and may offer confirmation of grossly identified villi. Positive predictive value is 100%. Negative touch preps should receive further evaluation. PMID: 27317440 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 16, 2016 Category: Pathology Authors: Chen AL, Tambouret RH, Roberts DJ Tags: Am J Clin Pathol Source Type: research

Comparison of Multiparameter Flow Cytometry Immunophenotypic Analysis and Quantitative RT-PCR for the Detection of Minimal Residual Disease of Core Binding Factor Acute Myeloid Leukemia.
CONCLUSIONS: MFC and qRT-PCR are complementary tests in monitoring CBF AML MRD. PMID: 27298396 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 12, 2016 Category: Pathology Authors: Ouyang J, Goswami M, Peng J, Zuo Z, Daver N, Borthakur G, Tang G, Medeiros LJ, Jorgensen JL, Ravandi F, Wang SA Tags: Am J Clin Pathol Source Type: research

Performances of the H-Score for Diagnosis of Hemophagocytic Lymphohistiocytosis in Adult and Pediatric Patients.
CONCLUSIONS: The adapted HLH-2004 guidelines seem less powerful and H-score seems to be more appropriate for children, which may be due to less significantly marked biological features. For adults, H-score performances are better when determined at presentation. The cutoff value of the H-score should be adapted depending on the target population to obtain optimal specificity. PMID: 27298397 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 12, 2016 Category: Pathology Authors: Debaugnies F, Mahadeb B, Ferster A, Meuleman N, Rozen L, Demulder A, Corazza F Tags: Am J Clin Pathol Source Type: research

Cold Antibodies in Cardiovascular Surgery: Is Preoperative Screening Necessary?
CONCLUSIONS: The incidence of intraoperative complications among our patients with CAs was only 4%; therefore, the use of special testing protocols for the preoperative identification of CAs is neither necessary nor justified. Patient risk is best managed by preoperative clinical evaluation for potentially pathogenic CAs and intraoperative vigilance for agglutination. PMID: 27298398 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 12, 2016 Category: Pathology Authors: Sapatnekar S, Figueroa PI Tags: Am J Clin Pathol Source Type: research

Biomarkers Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer.
CONCLUSIONS: In addition to the pathologic parameters and biomarkers already routinely assessed, evaluation of TLI and SLI may help to better select patients with HER2+ and TNBC for neoadjuvant chemotherapy. PMID: 27298399 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 12, 2016 Category: Pathology Authors: Li XB, Krishnamurti U, Bhattarai S, Klimov S, Reid MD, O'Regan R, Aneja R Tags: Am J Clin Pathol Source Type: research

Two Unrelated Burkitt Lymphomas Seven Years Apart in a Patient With X-Linked Lymphoproliferative Disease Type 1 (XLP1).
CONCLUSIONS: These results confirm that these two tumors represent unrelated BLs. Pathologists and clinicians should be aware that second lymphomas in XLP1 patients may represent new neoplasms rather than late relapses. PMID: 27287777 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 10, 2016 Category: Pathology Authors: Zhou D, Paxton CN, Kelley TW, Afify Z, South ST, Miles RR Tags: Am J Clin Pathol Source Type: research

Magnesium Sulfate as an Alternative In Vitro Anticoagulant for the Measurement of Platelet Parameters?
CONCLUSIONS: Magnesium anticoagulation might be advantageous for more reliable MPV measurements. Although platelet count is underestimated when the impedance method is used, the platelet count reveals similar results when measured by the fluorescent optical method. PMID: 27282617 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 8, 2016 Category: Pathology Authors: Mannuß S, Schuff-Werner P, Dreißiger K, Kohlschein P Tags: Am J Clin Pathol Source Type: research

Performance Characteristics of Commercial Immunoassays for the Detection of IgG and IgM Antibodies to β2 Glycoprotein I and an Initial Assessment of Newly Developed Reference Materials for Assay Calibration.
CONCLUSIONS: Although qualitative agreements between immunoassays for both antibody isotypes are acceptable, correlations with APS clinical manifestations were kit dependent. Only the use of IgG reference material improved quantitative correlations between assays. PMID: 27267373 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 6, 2016 Category: Pathology Authors: Willis R, Pierangeli SS, Jaskowski TD, Malmberg E, Guerra M, Salmon JE, Petri M, Branch DW, Tebo AE Tags: Am J Clin Pathol Source Type: research

Pathology Consultation on Patients With a Large Rh Immune Globulin Dose Requirement.
CONCLUSIONS: Accurate laboratory evaluation of women with large fetomaternal bleeds is essential for appropriate RhIG administration. PMID: 27267375 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 6, 2016 Category: Pathology Authors: Welsh KJ, Bai Y, Education Committee of the Academy of Clinical Laboratory Physicians and Scientists Tags: Am J Clin Pathol Source Type: research

T2Candida Provides Rapid and Accurate Species Identification in Pediatric Cases of Candidemia.
CONCLUSIONS: T2Candida can be used to efficiently diagnose or rule out candidemia using low-volume blood specimens from pediatric patients. This could result in improved time to appropriate antifungal therapy or reduction in unnecessary empirical antifungal therapy. PMID: 27247378 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 31, 2016 Category: Pathology Authors: Hamula CL, Hughes K, Fisher BT, Zaoutis TE, Singh IR, Velegraki A Tags: Am J Clin Pathol Source Type: research

Glutamine Synthetase Immunoreactivity in Peritumoral Hyperplasia in Liver: Case Report of a Metastatic Paraganglioma With Focal Nodular Hyperplasia-Like Changes and Review of an Additional 54 Liver Masses.
CONCLUSIONS: Peritumoral hyperplasia or FNH-like changes are uncommon findings around primary or metastatic lesions in the liver. GS immunohistochemistry assists in distinguishing true peritumoral hyperplasia from mass effect. PMID: 27247379 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 31, 2016 Category: Pathology Authors: Bryant BH, Zenali MJ, Swanson PE, Upton MP, Yeh MM, Cuevas C, Park JO, Westerhoff M Tags: Am J Clin Pathol Source Type: research

Advocating for Pathology.
PMID: 27247364 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

Histopathology of Graft-vs-Host Disease of Gastrointestinal Tract and Liver:  An Update.
CONCLUSIONS: Histopathologic examination remains the mainstay of diagnosis of gastrointestinal and liver GVHD and is interpreted in conjunction with clinical and laboratory data. PMID: 27247365 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Salomao M, Dorritie K, Mapara MY, Sepulveda A Tags: Am J Clin Pathol Source Type: research

An Immunohistochemical Survey of SNARE Proteins Shows Distinct Patterns of Expression in Hematolymphoid Neoplasia.
CONCLUSIONS: Differential SNARE protein expression in the lymphoid system may have potential use in diagnosis and may offer clues to lymphoma biology. VAMP2 is a promising new plasma cell marker. PMID: 27247366 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Bhat R, Bhattacharyya PK, Ratech H Tags: Am J Clin Pathol Source Type: research

Assessment of Melanocyte Density in Anorectal Mucosa for the Evaluation of Surgical Margins in Primary Anorectal Melanoma.
CONCLUSIONS: In the histopathologic assessment of AM resections, MITF and HMB45 immunostains aid in distinguishing between "trailing" MIS and BMH, by highlighting melanocyte density, nuclear atypia, and growth pattern, with the latter two being reliable features. VE1 showed nonspecific immunopositivity in anorectal glandular epithelium, a potential diagnostic pitfall when assessing BRAF mutation status. PMID: 27247367 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Tse JY, Chan MP, Zukerberg LR, Nazarian RM Tags: Am J Clin Pathol Source Type: research

Cystic Neutrophilic Granulomatous Mastitis:  Association With Gram-Positive Bacilli and Corynebacterium.
CONCLUSIONS: Our data further support CNGM as an infectious disease; further study of Corynebacterium-directed therapy in CNGM is needed. PMID: 27247368 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Troxell ML, Gordon NT, Doggett JS, Ballard M, Vetto JT, Pommier RF, Naik AM Tags: Am J Clin Pathol Source Type: research

Extreme Hyperferritinemia:  Causes and Impact on Diagnostic Reasoning.
CONCLUSIONS: Although this supports the relationship between extreme hyperferritinemia and HLH, it maintains that the positive predictive value of hyperferritinemia for HLH is quite low, and one should consider more common explanations before suspecting HLH. PMID: 27247369 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Sackett K, Cunderlik M, Sahni N, Killeen AA, Olson AP Tags: Am J Clin Pathol Source Type: research

Comparison of the Diagnostic Value Between Real-Time Reverse Transcription-Polymerase Chain Reaction Assay and Histopathologic Examination in Sentinel Lymph Nodes for Patients With Gastric Carcinoma.
CONCLUSIONS: The real-time RT-PCR assay could detect SLN metastasis in gastric cancer. However, the predictive value of the real-time RT-PCR assay was lower than that of precise histopathologic examination and did not outweigh that of our intraoperative SLN diagnosis. PMID: 27247370 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Kwak Y, Nam SK, Shin E, Ahn SH, Lee HE, Park do J, Kim WH, Kim HH, Lee HS Tags: Am J Clin Pathol Source Type: research

Warfarin Pharmacogenetics Reevaluated:  Subgroup Analysis Reveals a Likely Underestimation of the Maximum Pharmacogenetic Benefit by Clinical Trials.
CONCLUSIONS: Patient subgroups were identified that obtained the largest pharmacogenetic improvements in warfarin dose accuracy. These subgroups have not been analyzed in clinical trials to date, likely resulting in underestimation of the pharmacogenetic benefit. PMID: 27247371 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Stack G, Maurice CB Tags: Am J Clin Pathol Source Type: research

Optimal Minimal Panels of Immunohistochemistry for Diagnosis of B-Cell Lymphoma for Application in Countries With Limited Resources and for Triaging Cases Before Referral to Specialist Centers.
CONCLUSIONS: The panels/algorithms assist pathologists in practicing lymphoma diagnostics in countries with limited resources and in making lymphoma referrals to specialist centers. PMID: 27247372 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Disanto MG, Ambrosio MR, Rocca BJ, Ibrahim HA, Leoncini L, Naresh KN Tags: Am J Clin Pathol Source Type: research

Test Feasibility of Next-Generation Sequencing Assays in Clinical Mutation Detection of Small Biopsy and Fine Needle Aspiration Specimens.
CONCLUSIONS: NGS assays demonstrated clinical utility in solid tumor specimens, including those taken by biopsy or FNA. Preanalytic factors identified by this study that may contribute to NGS assay failure highlight the need for pathologists to revisit tissue processing protocols in order to better optimize cancer mutational profiling. PMID: 27247373 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Zheng G, Tsai H, Tseng LH, Illei P, Gocke CD, Eshleman JR, Netto G, Lin MT Tags: Am J Clin Pathol Source Type: research

Levamisole-Adulterated Cocaine Nephrotoxicity:  Ultrastructural Features.
CONCLUSIONS: The electron microscopic features of levamisole-adulterated cocaine toxicity are novel findings that are presented for the first time, to our knowledge, in this report. PMID: 27247374 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Liu YW, Mutnuri S, Siddiqui SB, Weikle GR, Oladipo O, Ganti N, Beach RE, Afrouzian M Tags: Am J Clin Pathol Source Type: research

Hemophagocytosis-Related (Asian Variant) Intravascular Large B-Cell Lymphoma in a Hispanic Patient:  A Case Report Highlighting a Micronodular Pattern in the Spleen.
CONCLUSIONS: Our observations provide the first molecular genetic support for a seemingly underrecognized micronodular pattern of IVLBCL in the spleen and further support the proposal of a "mixed variant" of IVLBCL with concomitant "intravascular" and "solid" phases of disease. PMID: 27247375 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 1, 2016 Category: Pathology Authors: Hall JM, Meyers N, Andrews J Tags: Am J Clin Pathol Source Type: research

Pathology Consultation on Influenza Diagnostics.
CONCLUSIONS: Diagnostic assays for influenza can vary greatly with regards to analytical performance characteristics, complexity, turnaround time and cost. This can have important patient care and infection prevention implications. PMID: 27124947 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 26, 2016 Category: Pathology Authors: McMullen AR, Anderson NW, Burnham CD, Education Committee of the Academy of Clinical Laboratory Physicians and Scientists Tags: Am J Clin Pathol Source Type: research

Mean Abnormal Result Rate: Proof of Concept of a New Metric for Benchmarking Selectivity in Laboratory Test Ordering.
CONCLUSIONS: The proposed metric represents a new utilization metric for benchmarking relative selectivity of test orders among physicians. PMID: 27124949 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 26, 2016 Category: Pathology Authors: Naugler CT, Guo M Tags: Am J Clin Pathol Source Type: research

Integration of Immature Granulocytes Quantification With the Version 2.0 UniCel DxH 800 in the HematoFlow Strategy.
CONCLUSIONS: The EGC% generated by the DxH 800 can be easily incorporated into existing HematoFlow and slide review algorithms. PMID: 27124946 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 23, 2016 Category: Pathology Authors: Pastoret C, Ly Sunnaram B, Fest T, Roussel M Tags: Am J Clin Pathol Source Type: research

Targeted Next-Generation Sequencing in Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia Aids Diagnosis in Challenging Cases and Identifies Frequent Spliceosome Mutations in Transformed Acute Myeloid Leukemia.
CONCLUSIONS: In difficult cases of MDS or MPN, NGS facilitates diagnosis by detection of gene mutations to confirm clonality, and AMLs evolving from MDS or MPN carry frequent mutations in spliceosomal genes. PMID: 27124934 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 22, 2016 Category: Pathology Authors: Reinig E, Yang F, Traer E, Arora R, Brown S, Rattray R, Braziel R, Fan G, Press R, Dunlap J Tags: Am J Clin Pathol Source Type: research

Prospective and Retrospective Diagnosis of Barth Syndrome Aided by Next-Generation Sequencing.
CONCLUSIONS: The investigation for Barth syndrome must be considered in male babies and young boys with dilated cardiomyopathy and left ventricular noncompaction. Next-generation sequencing technologies provide an accurate and rapid diagnostic tool in prospectively and retrospectively identifying individuals with this Mendelian syndrome. PMID: 27124939 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 22, 2016 Category: Pathology Authors: Brión M, de Castro López MJ, Santori M, Pérez Muñuzuri A, López Abel B, Baña Souto AM, Martínez Soto MI, Couce ML Tags: Am J Clin Pathol Source Type: research

Audit of Use and Overuse of Serum Protein Immunofixation Electrophoresis and Serum Free Light Chain Assay in Tertiary Health Care: A Case for Algorithmic Testing to Optimize Laboratory Utilization.
CONCLUSIONS: Fewer than half of the serum immunofixation and serum free light chain assays added value. The proposed algorithm for testing should improve utilization. Risk to part B billing may be a disincentive to reducing test utilization. PMID: 27124940 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 22, 2016 Category: Pathology Authors: Heaton C, Vyas SG, Singh G Tags: Am J Clin Pathol Source Type: research

Pure Erythroid Leukemia and Erythroblastic Sarcoma Evolving From Chronic Myeloid Neoplasms.
CONCLUSIONS: These data represent the largest cohort of patients with PEL and an antecedent CMN, as well as the largest series of EBS reported to date, and underscore the unique morphologic, cytogenetic, immunophenotypic, and clinical features of this uncommon entity. PMID: 27124944 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 22, 2016 Category: Pathology Authors: Li H, Hasserjian RP, Kroft SH, Harrington AM, Wheaton SE, Pildain A, Ewalt MD, Gratzinger D, Hosking P, Olteanu H Tags: Am J Clin Pathol Source Type: research

Prognostic Impact of Tumor Microenvironment in Diffuse Large B-Cell Lymphoma Uniformly Treated With R-CHOP Chemotherapy.
CONCLUSIONS: The concomitant evaluation of cell of origin along with tumor microenvironment components identifies patients with DLBCL treated with R-CHOP chemotherapy portraying a worse prognosis. PMID: 27124945 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 22, 2016 Category: Pathology Authors: Gomez-Gelvez JC, Salama ME, Perkins SL, Leavitt M, Inamdar KV Tags: Am J Clin Pathol Source Type: research

Follow-up of Women With Negative Pap Test Results and Abnormal Clinical Signs or Symptoms.
CONCLUSIONS: We report follow-up findings from patients with abnormal clinical signs or symptoms, negative Pap test results, and follow-up recommendations highlighting reported abnormal signs or symptoms. Abnormal clinical signs and symptoms should routinely be considered in assessment and management of patients with negative cervical screening test results. PMID: 27124948 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 22, 2016 Category: Pathology Authors: Ocque R, Austin RM Tags: Am J Clin Pathol Source Type: research

Thyroid Frozen Sections in Patients With Preoperative FNAs: Review of Surgeons' Preoperative Rationale, Intraoperative Decisions and Final Outcome.
CONCLUSIONS: The stated rationale for FSs in patients with preoperative FNA was not supported by patient outcome in most cases. There may be some utility for FSs in lesions with a suspicious for malignancy preoperative FNA diagnosis. PMID: 27124950 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 22, 2016 Category: Pathology Authors: Kennedy JM, Robinson RA Tags: Am J Clin Pathol Source Type: research

Pathology Consultation on Viscoelastic Studies of Coagulopathic Obstetrical Patients.
CONCLUSIONS: Additional research is needed to further focus the optimum role of viscoelastic tests in major obstetrical hemorrhage. PMID: 27124951 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 22, 2016 Category: Pathology Authors: Gehrie EA, Baine I, Booth GS, Education Committee of the Academy of Clinical Laboratory Physicians and Scientists Tags: Am J Clin Pathol Source Type: research

Radical Nephrectomy for Renal Cell Carcinoma: Its Contemporary Role Related to Histologic Type, Tumor Size and Nodal Status: A Retrospective Study.
CONCLUSIONS: LNS in RCC for staging purposes may be warranted based on tumor size (>4 cm) as determined by imaging as well as histologic cell type, the latter suggesting a selective role for preoperative fine needle aspiration or core biopsy. PMID: 27124952 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 22, 2016 Category: Pathology Authors: Mirza KM, Taxy JB, Antic T Tags: Am J Clin Pathol Source Type: research