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Is "Polysomy" in Breast Carcinoma the "New Equivocal" in HER2 Testing?
PMID: 26185303 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Swanson PE, Yang H Tags: Am J Clin Pathol Source Type: research

Importance of Fungal Histopathology in Immunocompromised Pediatric Patients: It's Not Just "Aspergillus" Anymore.
PMID: 26185304 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Schuetz AN, Walsh TJ Tags: Am J Clin Pathol Source Type: research

Acute Myeloid Leukemia and Other Types of Disease Progression in Myeloproliferative Neoplasms.
CONCLUSIONS: There was agreement that a definitive diagnosis can be challenging in the absence of documented review of prior diagnostic material and clinical history. PMID: 26185305 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Czader M, Orazi A Tags: Am J Clin Pathol Source Type: research

Therapy-Related Myeloid Neoplasms.
CONCLUSIONS: The study of TR-MNs will likely provide insight into the pathogenesis of de novo myeloid disease and may explain why some patients with cancer develop TR-MN and evidently have a higher genetic susceptibility, whereas most patients treated with the same agents do not. These studies will also result in critical reappraisal of current concepts related to TR-MNs. PMID: 26185306 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA Tags: Am J Clin Pathol Source Type: research

Extramedullary Manifestations of Myeloid Neoplasms.
CONCLUSIONS: In the era of targeted therapy and sophisticated risk stratification, every attempt must be made to perform a complete workup on MS cases (or concurrent AML) since the diagnosis of MS, in itself, is no longer adequate for patient management. Cases of blastic plasmacytoid dendritic cell neoplasm were also included and discussed in this session. PMID: 26185307 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Wilson CS, Medeiros LJ Tags: Am J Clin Pathol Source Type: research

Performance of a Tuberculosis Serologic Assay in Various Patient Populations.
CONCLUSIONS: This study confirmed the limitations of serodiagnosis for active tuberculosis, including poor sensitivity and increased reactivity with nontuberculous mycobacterium-positive patients. PMID: 26185308 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: She RC, Litwin CM Tags: Am J Clin Pathol Source Type: research

Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients.
CONCLUSIONS: CGAT was critical in the genotype clarification of these cases through detection of copy-neutral loss of heterozygosity and should be considered performing for B-ALL with apparent hyperdiploidy for accurate prognostic risk stratification and treatment planning. PMID: 26185311 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Fang M, Becker PS, Linenberger M, Eaton KD, Appelbaum FR, Dreyer Z, Airewele G, Redell M, Lopez-Terrada D, Patel A, Rabin KR, Lu X Tags: Am J Clin Pathol Source Type: research

Disparities in Interpretation of Primary Testicular Germ Cell Tumor Pathology.
CONCLUSIONS: Inaccurate interpretation of orchiectomy specimens is not uncommon and may lead to incorrect tumor staging, imprecise assignment of progression risk, and inappropriate management recommendations. Secondary opinions of primary GCT orchiectomy specimens potentially facilitate appropriate counseling and therapeutic strategies. PMID: 26185314 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Sharma P, Dhillon J, Agarwal G, Zargar-Shoshtari K, Sexton WJ Tags: Am J Clin Pathol Source Type: research

Cytoplasmic 5-Lipoxygenase Staining Is a Highly Sensitive Marker of Human Tumors of the Choroid Plexus.
CONCLUSIONS: Our findings indicate that cytoplasmic 5-LO immunoreactivity is highly characteristic of human choroid plexus tumors but not other central nervous system tumor types. Cytoplasmic staining for 5-LO may prove to be a useful immunoreactive marker in the diagnosis of choroid plexus tumors. PMID: 26185315 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Xingfu W, Lifeng Z, Yupeng C, Xueyong L, Wei L, Yinghao Y, Suqin C, Mi W, Sheng Z Tags: Am J Clin Pathol Source Type: research

Heterogeneity of Abnormal RUNX1 Leading to Clinicopathologic Variations in Childhood B-Lymphoblastic Leukemia.
CONCLUSIONS: RUNX1 copy numbers seem to be proportional to the age of B-ALL onset and the frequency of CSF involvement, while RUNX1 amplification vs translocation causes aberrant expression of CD7 and CD13, respectively. PMID: 26185316 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Knez VM, Carstens BJ, Swisshelm KL, McGranahan AN, Liang X Tags: Am J Clin Pathol Source Type: research

Attitudes, Practices, and Training on Informed Consent for Transfusions and Procedures: A Survey of Medical Students and Physicians.
CONCLUSIONS: Only 60% of respondents felt their informed consent training was adequate. Multiple areas of difficulty in obtaining proper informed consent were identified that should be addressed with focused training or written guidelines. PMID: 26185317 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Vossoughi SR, Macauley R, Sazama K, Fung MK Tags: Am J Clin Pathol Source Type: research

Thyroid Pathology Findings in Cowden Syndrome: A Clue for the Diagnosis of the PTEN Hamartoma Tumor Syndrome.
CONCLUSIONS: Pathologists play a crucial role in recognizing pathologic thyroid findings associated with PHTS for selecting patients for genetic testing. PMID: 26185318 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Cameselle-Teijeiro J, Fachal C, Cabezas-Agrícola JM, Alfonsín-Barreiro N, Abdulkader I, Vega-Gliemmo A, Hermo JA Tags: Am J Clin Pathol Source Type: research

Transiently Pink-Tinged Serum in a Patient With Multiple Myeloma and Anemia Undergoing Lenalidomide Treatment.
CONCLUSIONS: Upon administration, chemotherapeutic agents, such as lenalidomide, can immediately induce transient hemolysis, which can be visualized as transiently pink-tinged serum samples. PMID: 26185319 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Wedel W, Sofronescu AG Tags: Am J Clin Pathol Source Type: research

B-Lymphoblastic Leukemia in Patients With Chronic Lymphocytic Leukemia: A Report of Four Cases.
CONCLUSIONS: Our data suggest that at least some cases of B-LBL arising in patients with CLL are independent, secondary neoplasms rather than a manifestation of histologic transformation. PMID: 26185320 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Chakhachiro Z, Yin CC, Abruzzo LV, Aladily TN, Barron LL, Banks HE, Thomas DA, Keating M, Medeiros LJ, Huh YO Tags: Am J Clin Pathol Source Type: research

Primary Marginal Zone Lymphoma of the Subcutis Associated With Panniculitis and Fat Necrosis.
CONCLUSIONS: This case represents, to our knowledge, the first reported case of primary subcutaneous B-cell lymphoma closely associated with panniculitis. PMID: 26185321 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Chui MH, Kukreti V, Wei C, Delabie J Tags: Am J Clin Pathol Source Type: research

Minimal Coexpression of CD34+/CD56+ in Acute Promyelocytic Leukemia Is Associated With Relapse.
CONCLUSIONS: This case report suggests that the presence of a clone with minimal coexpression of CD34/CD56 in APML at initial diagnosis should not be neglected since it may be associated with earlier relapse. PMID: 26185322 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Maenhout TM, Moreau E, Van Haute I, Desmet S, Deeren D Tags: Am J Clin Pathol Source Type: research

Introduction to the 2013 Workshop of the Society for Hematopathology/European Association for Haematopathology.
PMID: 26071457 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Bueso Ramos CE, Medeiros LJ, Vega-Vazquez F Tags: Am J Clin Pathol Source Type: research

Acute Myeloid Leukemia With Recurrent Cytogenetic Abnormalities.
CONCLUSIONS: This review focuses on providing updated recommendations for the rapid diagnosis of APL, discussing the types and significance of variant RARA mutations in APL-like leukemias, and refining low-blast-count (oligoblastic) AML. In addition, the significance of unique morphologic, immunophenotypic, and genetic variations in AML defined by a recurrent cytogenetic abnormality is included. PMID: 26071458 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Foucar K, Anastasi J Tags: Am J Clin Pathol Source Type: research

Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
CONCLUSIONS: In aggregate, this session highlighted the need for a refined molecular classification of AML as well as improved risk stratification based on systematic assessment for genetic alterations and their evolution over time. PMID: 26071459 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Lin P, Falini B Tags: Am J Clin Pathol Source Type: research

Acute Myeloid Leukemia With Myelodysplasia-Related Changes.
CONCLUSIONS: Whole-genome sequencing and array studies may identify genetic abnormalities, such as those affecting TP53, which may provide prognostic information. PMID: 26071460 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Vardiman J, Reichard K Tags: Am J Clin Pathol Source Type: research

Acute Erythroleukemias, Acute Megakaryoblastic Leukemias, and Reactive Mimics: A Guide to a Number of Perplexing Entities.
CONCLUSIONS: The broad spectrum of cases illustrated the difficulties and complex issues involved in establishing a diagnosis of these entities and the need for better disease definitions. PMID: 26071461 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Wang SA, Hasserjian RP Tags: Am J Clin Pathol Source Type: research

Positive Impact of Fungal Histopathology on Immunocompromised Pediatric Patients With Histology-Proven Invasive Fungal Infection.
CONCLUSIONS: Histology can provide rapid, accurate, and clinically actionable information to clinicians caring for children with IFI. PMID: 26071462 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Dekio F, Bhatti TR, Zhang SX, Sullivan KV Tags: Am J Clin Pathol Source Type: research

Comparative Analysis Reveals Potential Utility of Digital Microscopy in the Evaluation of Peripheral Blood Smears With Some Barriers to Implementation.
CONCLUSIONS: These results support the limited use of digital microscopy for evaluation and triage of peripheral blood smears as a practical option to obtain expert opinion in locations where experienced staff is not available on site. Our results indicate that while digital microscopy is well suited for basic triage of these blood smears, limitations in quality of imaging at higher magnification as well as large file size may limit its utility in certain settings and situations. PMID: 26071463 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Gomez-Gelvez JC, Kryvenko ON, Chabot-Richards DS, Foucar K, Inamdar KV, Karner KH Tags: Am J Clin Pathol Source Type: research

Isolated del(5q) in Patients Following Therapies for Various Malignancies May Not All Be Clinically Significant.
CONCLUSIONS: Development of del(5q) in patients following cytotoxic therapies or TKI may not always be associated with t-MN. A close follow-up seems an appropriate approach for patients who had a minor del(5q) clone. PMID: 26071464 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Tang G, Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, DiNardo C, Medeiros LJ Tags: Am J Clin Pathol Source Type: research

Immunohistochemistry for BRAF V600E in the Differential Diagnosis of Hairy Cell Leukemia vs Other Splenic B-Cell Lymphomas.
CONCLUSIONS: The detection of BRAF V600E by IHC is useful in the distinction of HCLs from other splenic-based lymphomas, although the identification of at least rare SMZLs containing this abnormality illustrates the continuing need for a multiparameter approach to diagnosis. PMID: 26071465 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Turakhia S, Lanigan C, Hamadeh F, Swerdlow SH, Tubbs RR, Cook JR Tags: Am J Clin Pathol Source Type: research

Neutropenia in Congenital and Adult Babesiosis.
CONCLUSIONS: Neutropenia appears to be a common finding in infants with congenital babesiosis and is also observed not infrequently in adults with this infection. PMID: 26071466 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Wormser GP, Villafuerte P, Nolan SM, Wang G, Lerner RG, Saetre KL, Maria MH, Branda JA Tags: Am J Clin Pathol Source Type: research

Yearly Clinical Laboratory Test Expenditures for Different Medical Specialties in a Major Canadian City.
CONCLUSIONS: There was wide variation in clinical laboratory test expenditures among specialties and on a per capita basis within medical specialties. PMID: 26071467 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Naugler C, Thomas R, Turin TC, Guo M, Vaska M, COAPT (Collaboration On Assessing Physician Testing) Tags: Am J Clin Pathol Source Type: research

Cytogenetic Variation of B-Lymphoblastic Leukemia With Intrachromosomal Amplification of Chromosome 21 (iAMP21): A Multi-Institutional Series Review.
CONCLUSIONS: Our findings not only demonstrate that B-ALL with iAMP21 is truly a distinct clinicopathologic entity but also suggest that a subset of cases of B-ALL with iAMP21 can show variable cytogenetic features. PMID: 26071468 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Johnson RC, Weinberg OK, Cascio MJ, Dahl GV, Mitton BA, Silverman LB, Cherry AM, Arber DA, Ohgami RS Tags: Am J Clin Pathol Source Type: research

Utility of Human Papillomavirus Capsid Protein L1 and p16 in the Assessment and Accurate Classification of Anal Squamous Intraepithelial Lesions.
CONCLUSIONS: HPV L1 and diffuse p16 expression is mutually exclusive in most anal SILs and helps separate LSIL and HSIL cases. Application of both HPV L1 and p16 can not only facilitate accurate grading but also contribute to risk assessment in anal neoplasia. PMID: 26071469 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Patil DT, Yang B Tags: Am J Clin Pathol Source Type: research

Daily Management System of the Henry Ford Production System: QTIPS to Focus Continuous Improvements at the Level of the Work.
CONCLUSIONS: Daily management is the key business accountability subsystem that enabled our culture of continuous improvement to function more efficiently at the managerial level in a visible manner by reviewing and acting based on data and root cause analysis. PMID: 26071470 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Zarbo RJ, Varney RC, Copeland JR, D'Angelo R, Sharma G Tags: Am J Clin Pathol Source Type: research

Spectrum of Clonal Large Granular Lymphocytes (LGLs) of αβ T Cells: T-Cell Clones of Undetermined Significance, T-Cell LGL Leukemias, and T-Cell Immunoclones.
CONCLUSIONS: Most of the LGLT clones detected by flow cytometry were small and did not change the clinical management. We propose the following terminology: T-cell clones of undetermined significance, LGLT leukemias, and T-cell immunoclones. PMID: 26071471 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Singleton TP, Yin B, Teferra A, Mao JZ Tags: Am J Clin Pathol Source Type: research

Temperature-Sensitive Indicators for Monitoring RBC Concentrates Out of Controlled Temperature Storage.
CONCLUSIONS: TIs identified a considerable number of RBC concentrates whose temperatures may not be adequately reflected by the 30-minute rule. Variability of readings between TIs stresses the necessity of validation prior to implementation. PMID: 26071472 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Sigle JP, Holbro A, Lehmann T, Infanti L, Gerull S, Stern M, Tichelli A, Passweg J, Buser A Tags: Am J Clin Pathol Source Type: research

Evaluation of Quantitative Digital Pathology in the Assessment of Barrett Esophagus-Associated Dysplasia.
CONCLUSIONS: QDP is a promising tool in the new era of digital pathology. Pending clinical validation studies, analysis of chromatin texture could contribute to the differential diagnosis of BE class and the detection of concomitant high-grade lesions if not sampled. PMID: 26071473 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: El Hallani S, Guillaud M, Korbelik J, Marginean EC Tags: Am J Clin Pathol Source Type: research

The Prevalence of JAK2, MPL, and CALR Mutations in Chinese Patients With BCR-ABL1-Negative Myeloproliferative Neoplasms.
CONCLUSIONS: The combined genetic tests of JAK2 V617F, JAK2 exon 12, MPL exon 10, and CALR exon 9 help improve the diagnostic rate for BCR-ABL1-negative MPN. PMID: 26071474 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Lin Y, Liu E, Sun Q, Ma J, Li Q, Cao Z, Wang J, Jia Y, Zhang H, Song Z, Ai X, Shi L, Feng X, Li C, Wang J, Ru K Tags: Am J Clin Pathol Source Type: research

Media Review.
PMID: 26071475 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Hoda SA, Ginter PS Tags: Am J Clin Pathol Source Type: research

Clinical Utility of Lactate Dehydrogenase in Determining the Severity of Hemolysis in Sickle Cell Anemia.
PMID: 26071476 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Ballas SK, Jialal I, Rashidi HH, Sokoll LJ Tags: Am J Clin Pathol Source Type: research

Alveolar Pneumocytes Entrapping Pathologists.
PMID: 26071477 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Authors: Rossi G, Pereira-Santos P, Cavazza A Tags: Am J Clin Pathol Source Type: research

Correction.
Authors: PMID: 26071478 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Diagnostic microbiology: the accelerating transition from culture-based to molecular-based methods.
PMID: 25972317 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

Molecular Pathology of Hereditary and Sporadic Medullary Thyroid Carcinomas.
CONCLUSIONS: Molecular genetic testing is routinely performed to identify hereditary cases. In addition, understanding the molecular basis of both hereditary and sporadic MTC has led to the development of targeted therapy with tyrosine kinase inhibitors. Although additional data are needed, tumor mutation status may affect response to targeted therapy. Therefore, it is possible that genetic testing of tumor tissue to predict treatment response, as is currently done for other cancer types, may come into practice in the future. PMID: 25972318 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Chernock RD, Hagemann IS Tags: Am J Clin Pathol Source Type: research

KRAS Mutations in Mucinous Lesions of the Uterus.
CONCLUSIONS: The results suggest a possible association between KRAS mutations and mucinous differentiation in endometrial carcinogenesis. KRAS status can help in assessing benign from precursor or malignant mucinous lesions as well as differentiate endometrial lesions from those of cervical origin. PMID: 25972319 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: He M, Jackson CL, Gubrod RB, Breese V, Steinhoff M, Lawrence WD, Xiong J Tags: Am J Clin Pathol Source Type: research

Flow cytometric identification of immunophenotypically aberrant T-cell clusters on skin shave biopsy specimens from patients with mycosis fungoides.
CONCLUSIONS: FC is capable of identifying putative neoplastic cells on SSB specimens from patients with MF. Bright homogeneous CD26 expression is a common and previously undescribed immunophenotypic aberrancy on MF skin infiltrates. PMID: 25972320 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Horna P, Kurant D, Sokol L, Sotomayor EM, Moscinski L, Glass LF Tags: Am J Clin Pathol Source Type: research

Lymphoplasmacytic lymphoma and marginal zone lymphoma in the bone marrow: paratrabecular involvement as an important distinguishing feature.
CONCLUSIONS: LPL can be reliably distinguished from MZL in the bone marrow by using a combination of pathology characteristics. Our findings stress the diagnostic importance of using the combination of the following parameters for a correct LPL diagnosis: paratrabecular infiltration, the presence of lymphoplasmacytoid cells and cells with Dutcher bodies, and an increased number of mast cells in addition to the presence of MYD88 mutation. PMID: 25972321 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Bassarova A, Trøen G, Spetalen S, Micci F, Tierens A, Delabie J Tags: Am J Clin Pathol Source Type: research

Consultative issues in surgical neuropathology: a retrospective review of the rationale for submitting cases for expert review.
CONCLUSIONS: Pathologists who predominately submit cases with a preliminary diagnosis rendered seek expert consultation while clinicians seek a second opinion. PMID: 25972322 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Lipp ES, Clark AC, McLendon RE Tags: Am J Clin Pathol Source Type: research

Osteopontin Regulates VEGFA and ICAM-1 mRNA Expression in Breast Carcinoma.
CONCLUSIONS: Our results support that osteopontin regulates ICAM-1 and VEGFA expression mainly in triple-negative/basal-like breast carcinomas, suggesting a relevant role in the pathogenesis and tumor progression of this molecular subtype. Moreover, VEGFA mRNA levels showed an independent prognostic value in patients with breast cancer. PMID: 25972323 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Ortiz-Martínez F, Sanmartín E, Pomares-Navarro E, Pérez-Balaguer A, Andrés L, Sánchez-Payá J, Aranda FI, Lerma E, Peiró G Tags: Am J Clin Pathol Source Type: research

Differential diagnostic value of "blue reticulated chondroid-like material" in aneurysmal bone cysts: a classic histopathologic analysis of 215 cases.
CONCLUSIONS: BRC appears to be a unique histopathologic feature of ABC, making it valuable to differentiate benign ABC from TOS. Simple H&E stain can be economically performed anywhere. PMID: 25972324 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Bahk WJ, Mirra JM Tags: Am J Clin Pathol Source Type: research

p16/CDKN2A FISH in Differentiation of Diffuse Malignant Peritoneal Mesothelioma From Mesothelial Hyperplasia and Epithelial Ovarian Cancer.
CONCLUSIONS: Our study suggests that p16 FISH analysis is useful in differentiating DMPM from RMH and EOC when homozygous deletion is detected. PMID: 25972325 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Ito T, Hamasaki M, Matsumoto S, Hiroshima K, Tsujimura T, Kawai T, Shimao Y, Marutsuka K, Moriguchi S, Maruyama R, Miyamoto S, Nabeshima K Tags: Am J Clin Pathol Source Type: research

Salivary gland tumor fine-needle aspiration cytology: a proposal for a risk stratification classification.
CONCLUSIONS: Salivary gland FNA categorization into commonly encountered morphologic categories provides risk stratification, which translates to a simplified classification scheme of benign, NUMP, suspicious, and positive for malignancy similar to the paradigm in other organ systems. PMID: 25972326 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Griffith CC, Pai RK, Schneider F, Duvvuri U, Ferris RL, Johnson JT, Seethala RR Tags: Am J Clin Pathol Source Type: research

A case series of clinically undiagnosed hematopoietic neoplasms discovered at autopsy.
CONCLUSIONS: These cases illustrate the importance of the traditional postmortem examination in not only confirming clinical diagnoses but also identifying previously unknown diagnoses. Hematologic malignancies may present with nonspecific clinical manifestations, and this series of cases also emphasizes the necessity for widening the differential diagnosis in patients with unexplained lactic acidosis and hepatic failure to include hematopoietic malignancies since prompt treatment may be lifesaving. PMID: 25972327 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Podduturi V, Guileyardo JM, Soto LR, Krause JR Tags: Am J Clin Pathol Source Type: research

Low-cost workflow improvement reduces gastrointestinal block use 17% by altering classic histotechnology testing.
CONCLUSIONS: This simple, low-cost, low-effort process change yielded immediate and significant time savings for grossing and histology staff, increased job satisfaction, and challenges conventional histotechnology teaching. PMID: 25972328 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 15, 2015 Category: Pathology Authors: Steussy B, Gailey M, Becker K, Fuller E, Jans M, Lewis S, Guerin L, Kirby P, Robinson R Tags: Am J Clin Pathol Source Type: research