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Evaluation of treponemal serum tests performed on cerebrospinal fluid for diagnosis of neurosyphilis.
CONCLUSIONS: Treponemal serum tests performed on CSF were useful in identifying two patients with nonreactive CSF-VDRL. PMID: 25779998 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Guarner J, Jost H, Pillay A, Sun Y, Cox D, Notenboom R, Workowski K Tags: Am J Clin Pathol Source Type: research

Follow-up Outcomes in a Large Cohort of Patients With HPV-Negative LSIL Cervical Screening Test Results.
CONCLUSIONS: This is the largest study documenting follow-up results for patients with HPV-negative LSIL results based on prevalent US FDA-approved cotesting methods from one collection vial. These data document that risk for follow-up HSILs in these patients is low and also that no cervical cancers were diagnosed. These findings support recent recommendations for repeat cotesting after 1 year as an appropriate option for patients with HPV-negative LSIL results. PMID: 25779999 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Barron S, Austin RM, Li Z, Zhao C Tags: Am J Clin Pathol Source Type: research

Relationship of pathologic factors to efficacy of sorafenib treatment in patients with metastatic clear cell renal cell carcinoma.
CONCLUSIONS: As a novel histologic prognostic parameter, growth pattern may be useful for predicting response to sorafenib treatment. PMID: 25780000 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Araki H, Tsuzuki T, Kimura T, Tanaka K, Yamada S, Sassa N, Yoshino Y, Hattori R, Gotoh M Tags: Am J Clin Pathol Source Type: research

Detection of BRAF Mutations on Direct Smears of Thyroid Fine-Needle Aspirates Through Cell Transfer Technique.
CONCLUSIONS: PCR-based BRAF mutational testing can be reliably performed on the direct smears of the thyroid FNA specimens through the application of CTT. PMID: 25780001 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Shi Q, Ibrahim A, Herbert K, Carvin M, Randolph M, Post KM, Curless K, Chen S, Cramer HM, Cheng L, Wu HH Tags: Am J Clin Pathol Source Type: research

Primary sclerosing cholangitis: detailed histologic assessment and integration using bioinformatics highlights arterial fibrointimal hyperplasia as a novel feature.
CONCLUSIONS: This study demonstrates characteristic PSC histology as well as arterial hyperplasia to be distinctive features that may aid in PSC diagnosis and be confirmed by bioinformatics. PMID: 25780002 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Carrasco-Avino G, Schiano TD, Ward SC, Thung SN, Fiel MI Tags: Am J Clin Pathol Source Type: research

Expression of Bcl-xL and Mcl-1 in the Nonmelanoma Skin Cancers of Renal Transplant Recipients.
CONCLUSIONS: It was shown for the first time that Bcl-xL and Mcl-1 expression are widespread in the peritumoral epidermis and NMSC of renal transplant recipients. Importantly in NMSC, Bcl-xL expression was reduced with immunosuppression exposure, and Mcl-1 expression was reduced in tacrolimus-treated compared with sirolimustreated patients. PMID: 25780003 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Burke MT, Morais C, Oliver KA, Lambie DL, Gobe GC, Carroll RP, Staatz CE, Sinnya S, Soyer HP, Winterford C, Haass NK, Campbell SB, Isbel NM Tags: Am J Clin Pathol Source Type: research

Mast Cells in Systemic Mastocytosis Have Distinctly Brighter CD45 Expression by Flow Cytometry.
CONCLUSIONS: A combination of bright CD45 and CD25 appears to specifically identify abnormal mast cells in cases of systemic mastocytosis. Further studies will be necessary to confirm these results. PMID: 25780004 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Chisholm KM, Merker JD, Gotlib JR, Gitana G, Lefterova M, Zehnder JL, George TI, Arber DA, Ohgami RS Tags: Am J Clin Pathol Source Type: research

Adequacy of Powered vs Manual Bone Marrow Biopsy Specimens: A Retrospective Review of Sequential Marrow Aspirates and Biopsies in 68 Patients.
CONCLUSIONS: Our findings show that longer core biopsy specimens are obtained by the OnControl Bone Marrow system but that the manual method is still superior when the percentage and length of evaluable bone marrow are analyzed. PMID: 25780005 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Lynch DW, Stauffer SL, Rosenthal NS Tags: Am J Clin Pathol Source Type: research

BCL6 Expression Correlates With the t(1;19) Translocation in B-Lymphoblastic Leukemia.
CONCLUSIONS: BCL6 expression is present in a subset of B-lymphoblastic leukemias, especially in cases containing the 1;19 translocation. Investigation for TCF3(E2A)-PBX1 rearrangements may be useful in BCL6-positive B-lymphoblastic leukemia. PMID: 25780007 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Deucher AM, Qi Z, Yu J, George TI, Etzell JE Tags: Am J Clin Pathol Source Type: research

Effect of blood sampling, processing, and storage on the measurement of complement activation biomarkers.
CONCLUSIONS: The results from this study thus provide crucial guidelines for future investigations using complement biomarkers to define the role of complement system in disease. PMID: 25780008 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Yang S, McGookey M, Wang Y, Cataland SR, Wu HM Tags: Am J Clin Pathol Source Type: research

Laboratory quality improvement in Tanzania.
CONCLUSIONS: The article describes the progress made in Tanzania's first cohorts, the obstacles encountered, and the lessons learned during the pilot and subsequent implementations. PMID: 25780009 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Andiric LR, Massambu CG Tags: Am J Clin Pathol Source Type: research

Comparison of next-generation sequencing and mutation-specific platforms in clinical practice.
CONCLUSIONS: Sensitivity for detecting mutations was highly comparable among all platforms. The choice for either a dedicated genotyping platform or an NGS platform is basically a trade-off between speed and genetic information. PMID: 25780010 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Hinrichs JW, Marja van Blokland WT, Moons MJ, Radersma RD, Radersma-van Loon JH, de Voijs CM, Rappel SB, Koudijs MJ, Besselink NJ, Willems SM, de Weger RA Tags: Am J Clin Pathol Source Type: research

Validation of hemolysis index thresholds optimizes detection of clinically significant hemolysis.
CONCLUSIONS: Mean measured potassium concentrations are not clinically significantly affected by hemolysis at the manufacturer-recommended HI threshold, while AST and LDH are. Aligning reporting of sample hemolysis with clinically significant changes provides clinically meaningful alerts regarding this common preanalytic error. PMID: 25780011 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Goyal T, Schmotzer CL Tags: Am J Clin Pathol Source Type: research

Expression of metabolism-related proteins in lacrimal gland adenoid cystic carcinoma.
CONCLUSIONS: Lacrimal gland ACC exhibited higher expression of GLS1 and ASCT2, compared with salivary gland ACC. Overexpression of MCT4, PSPH, and SHMT1 was associated with poorer prognosis. PMID: 25780012 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Koo JS, Yoon JS Tags: Am J Clin Pathol Source Type: research

Dermatopathologists' opinions about the quality of clinical information in the skin biopsy requisition form and the skin biopsy care process: a semiqualitative assessment.
CONCLUSIONS: Dermatopathologists communicated that missing clinical information in the RF and inadequate specimens are common and adversely affect the quality of care. Multiple provider- and practice-related factors contribute to communication failures and deserve further investigation. PMID: 25780013 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Wong C, Peters M, Tilburt J, Comfere N Tags: Am J Clin Pathol Source Type: research

Clinicopathologic Evaluation of MYC Expression in Primary Mediastinal (Thymic) Large B-Cell Lymphoma.
CONCLUSIONS: MYC protein expression by IHC is present in most PMBLs. Increased MYC protein expression can be seen in one-third of the cases; however, it does not correlate with genetic abnormalities by FISH. There is also no significant impact of MYC protein expression on clinical outcomes. PMID: 25780014 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Li KD, Miles R, Tripp SR, Glenn MJ, Perkins SL, Salama M Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25780015 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Correction.
Authors: PMID: 25780016 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Waste not, want not.
PMID: 25696787 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Hannon T Tags: Am J Clin Pathol Source Type: research

Screening for Lynch Syndrome: A No-Brainer: BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor.
PMID: 25696788 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Bellizzi AM Tags: Am J Clin Pathol Source Type: research

Quality pathology and laboratory diagnostic services are key to improving global health outcomes: improving global health outcomes is not possible without accurate disease diagnosis.
PMID: 25696789 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: African Strategies for Advancing Pathology Group Members Tags: Am J Clin Pathol Source Type: research

Effectiveness of multiple initiatives to reduce blood component wastage.
CONCLUSIONS: Relatively inexpensive interventions can have a prompt and dramatic impact on reducing blood wastage with regard to both cost and resource savings. PMID: 25696790 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Collins RA, Wisniewski MK, Waters JH, Triulzi DJ, Yazer MH Tags: Am J Clin Pathol Source Type: research

A Modified Lynch Syndrome Screening Algorithm in Colon Cancer: BRAF Immunohistochemistry Is Efficacious and Cost Beneficial.
CONCLUSIONS: BRAF V600E IHC was concordant between TMAs, biopsy specimens, and whole-section slides, suggesting biopsy specimens are as useful as whole sections. IHC remained cost beneficial compared with mutational analysis, even though more patients needed additional molecular testing to exclude Lynch syndrome. PMID: 25696791 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Roth RM, Hampel H, Arnold CA, Yearsley MM, Marsh WL, Frankel WL Tags: Am J Clin Pathol Source Type: research

Use of hTERT and HPV E6/E7 mRNA RT-qPCR TaqMan Assays in Combination for Diagnosing High-Grade Cervical Lesions and Malignant Tumors.
CONCLUSIONS: These data suggest that the combination of HPV E6/E7 and hTERT mRNA expression levels could be used in a complementary manner in diagnosing high-grade cervical lesions and malignant tumors and might be useful as a predictive marker in monitoring low-grade cervical lesions. PMID: 25696792 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Wang HY, Park S, Kim S, Lee D, Kim G, Kim Y, Park KH, Lee H Tags: Am J Clin Pathol Source Type: research

Effects of levonorgestrel-releasing intrauterine system on lymphangiogenesis of adenomyosis.
CONCLUSIONS: Treatment with the LNG-IUS resulted in reduced lymphangiogenesis and LVD in the endometrial and myometrial tissues of patients with adenomyosis. Reduced lymphangiogenesis may be one mechanism by which the LNG-IUS reduces adenomyosis-related symptoms. PMID: 25696793 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Cho S, Choi YS, Yun BH, Chon SJ, Jung YS, Kim HY, Park JH, Seo SK, Kim SH, Lee BS Tags: Am J Clin Pathol Source Type: research

Diagnostic and Prognostic Value of BCL2 Rearrangement in 53 Patients With Follicular Lymphoma Presenting as Primary Skin Lesions.
CONCLUSIONS: We observed that BCL2 rearrangement in PCFCL is rare, associated with initial positivity of staging (diagnostic value) or with secondary extracutaneous spreading (prognostic value). In selected cases with BCL2-CD10 coexpression, FISH testing could detect patients with poor outcome and require closer monitoring. PMID: 25696794 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Pham-Ledard A, Cowppli-Bony A, Doussau A, Prochazkova-Carlotti M, Laharanne E, Jouary T, Belaud-Rotureau MA, Vergier B, Merlio JP, Beylot-Barry M Tags: Am J Clin Pathol Source Type: research

Left-Sided Early-Onset vs Late-Onset Colorectal Carcinoma: Histologic, Clinical, and Molecular Differences.
CONCLUSIONS: Our results suggest that left-sided CRCs may present differential patterns of aberrant DNA methylation when they are separated by age. PMID: 25696795 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Pilozzi E, Maresca C, Duranti E, Giustiniani MC, Catalanotto C, Lucarelli M, Cogoni C, Ferri M, Ruco L, Zardo G Tags: Am J Clin Pathol Source Type: research

Interobserver Variability of Mitotic Index and Utility of PHH3 for Risk Stratification in Gastrointestinal Stromal Tumors.
CONCLUSIONS: PHH3 may thus be a valuable adjunct for risk stratification in GISTs. PMID: 25696796 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Alkhasawneh A, Reith JD, Toro TZ, Ayed AO, Lu X, George TJ, Duckworth LV Tags: Am J Clin Pathol Source Type: research

Impact of an educational intervention on the frequency of daily blood test orders for hospitalized patients.
CONCLUSIONS: Provider education and reminders can reduce the frequency of daily blood tests ordered by providers for hospitalized patients. This can decrease health care costs and may reduce the risk of complications such as anemia. PMID: 25696797 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Thakkar RN, Kim D, Knight AM, Riedel S, Vaidya D, Wright SM Tags: Am J Clin Pathol Source Type: research

Liver metastases of small intestine neuroendocrine tumors: ki-67 heterogeneity and world health organization grade discordance with primary tumors.
CONCLUSIONS: Intratumoral and intertumoral Ki-67 heterogeneity is common and positively correlated with tumor size. The presence of one or more grade 3 liver lesions predicts a worse prognosis. PMID: 25696798 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Shi C, Gonzalez RS, Zhao Z, Koyama T, Cornish TC, Hande KR, Walker R, Sandler M, Berlin J, Liu EH Tags: Am J Clin Pathol Source Type: research

Building capacity in laboratory medicine in Africa by increasing physician involvement: a laboratory medicine course for clinicians.
CONCLUSIONS: Knowledge and awareness of the role of the laboratory increased after participation in the course. Understanding of laboratory medicine principles by clinicians will likely improve use of laboratory services and build capacity in Africa. PMID: 25696799 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Guarner J, Amukele T, Mehari M, Gemechu T, Woldeamanuel Y, Winkler AM, Asrat D, Wilson ML, Del Rio C Tags: Am J Clin Pathol Source Type: research

Visual memory effects on intraoperator study design: determining a minimum time gap between case reviews to reduce recall bias.
CONCLUSIONS: Pathologists were capable of recalling from memory cases seen previously at 2 and 4 weeks. Recall rates may be sufficiently high to affect intraobserver study design. PMID: 25696800 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Campbell WS, Talmon GA, Foster KW, Baker JJ, Smith LM, Hinrichs SH Tags: Am J Clin Pathol Source Type: research

Immunohistochemical distinction of primary sweat gland carcinoma and metastatic breast carcinoma: can it always be accomplished reliably?
CONCLUSIONS: These data suggest that p63 and CK5/6 are specific determinants for sweat gland carcinoma in the stated setting. In the absence of those analytes, metastatic breast carcinoma cannot always be identified to the exclusion of a primary tumor. This diagnostic scenario continues to require the procurement of a detailed clinical history regarding the number and duration of skin lesions in any given case. PMID: 25696802 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Mentrikoski MJ, Wick MR Tags: Am J Clin Pathol Source Type: research

VE1 Antibody Is Not Highly Specific for the BRAF V600E Mutation in Thyroid Cytology Categories With the Exception of Malignant Cases.
CONCLUSIONS: VE1 immunocytochemistry in thyroid FNAC as a screening test for BRAF mutations is highly specific for malignant category cases but can be suboptimal due to its high false-positive rate for the nonmalignant cases. PMID: 25696803 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Lee SR, Yim H, Han JH, Lee KB, Lee J, Soh EY, Kim DJ, Chung YS, Jeong SY, Sheen SS, Park SH, Kim JH Tags: Am J Clin Pathol Source Type: research

Normal villous architecture with increased intraepithelial lymphocytes: a duodenal manifestation of crohn disease.
CONCLUSIONS: We propose that Crohn disease be included in the differential diagnosis for increased IELs with normal villous architecture in duodenal biopsy specimens, particularly when gastric biopsy specimens show focal gastritis. PMID: 25696804 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Patterson ER, Shmidt E, Oxentenko AS, Enders FT, Smyrk TC Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25696806 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Media Review.
PMID: 25696807 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Yantiss RK Tags: Am J Clin Pathol Source Type: research

Media Review.
PMID: 25696808 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Hoda SA, Ginter PS Tags: Am J Clin Pathol Source Type: research

Clinical utility of lactate dehydrogenase: a historical perspective.
PMID: 25596240 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Jialal I, Sokoll LJ Tags: Am J Clin Pathol Source Type: research

Detection of Human Papillomavirus 16, 18, and 45 in Women With ASC-US Cytology and the Risk of Cervical Precancer: Results From the CLEAR HPV Study.
CONCLUSIONS: We demonstrated that AHPV-GT is a reliable and effective test for cervical cancer risk stratification in women with an ASC-US cytology diagnosis. PMID: 25596241 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Castle PE, Cuzick J, Stoler MH, Wright TC, Reid JL, Dockter J, Giachetti C, Getman D Tags: Am J Clin Pathol Source Type: research

Automatic recognition of atypical lymphoid cells from peripheral blood by digital image analysis.
CONCLUSIONS: The method reaches a high precision in the recognition of five different types of lymphoid cells and could allow for the design of a diagnosis support tool in the future. PMID: 25596242 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Alférez S, Merino A, Bigorra L, Mujica L, Ruiz M, Rodellar J Tags: Am J Clin Pathol Source Type: research

The Vascular Marker CD31 Also Highlights Histiocytes and Histiocyte-Like Cells Within Cutaneous Tumors.
CONCLUSIONS: Our results indicate that CD31 can mark lesional cells and imitate vascular tumors in cutaneous histiocytomas and histiocytoma mimics, an error that can be avoided by using a panel of antibodies. PMID: 25596243 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Vanchinathan V, Mizramani N, Kantipudi R, Schwartz EJ, Sundram UN Tags: Am J Clin Pathol Source Type: research

Detection of acetylcholine receptor modulating antibodies by flow cytometry.
CONCLUSIONS: The new flow cytometric method using the RD cell platform provided higher quality clinical results, a more robust and efficient assay format, a significant cost savings, and less environmental burden. PMID: 25596244 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Lozier BK, Haven TR, Astill ME, Hill HR Tags: Am J Clin Pathol Source Type: research

Adequacy of core needle biopsy specimens and fine-needle aspirates for molecular testing of lung adenocarcinomas.
CONCLUSIONS: When paraffin-embedded tissue is used for molecular testing of lung cancer, CNB specimens are more likely than FNA specimens to provide adequate tissue for molecular testing. Obtaining a sufficient FNA specimen depends on the tumor size and the individual performing the biopsy. PMID: 25596245 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Schneider F, Smith MA, Lane MC, Pantanowitz L, Dacic S, Ohori NP Tags: Am J Clin Pathol Source Type: research

Bone marrow necrosis: ten-year retrospective review of bone marrow biopsy specimens.
CONCLUSIONS: The causes of bone marrow necrosis are diverse but should always prompt careful assessment for malignancy and infectious etiology. PMID: 25596246 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Wool GD, Deucher A Tags: Am J Clin Pathol Source Type: research

Flow cytometric analysis of lymphoid enhancer-binding factor 1 in diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma.
CONCLUSIONS: Flow cytometric analysis of LEF1 is sufficient to differentiate CLL/SLL from other small B-cell lymphomas and may serve as a useful tool in the diagnosis of CLL/SLL. PMID: 25596247 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Amador-Ortiz C, Goolsby CL, Peterson LC, Wolniak KL, McLaughlin JL, Gao J, Chen YH Tags: Am J Clin Pathol Source Type: research

Thyroid carcinoma showing thymus-like elements: a clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis.
CONCLUSIONS: GLUT-1 can be used as a novel biomarker for CASTLE, and combined detection of GLUT-1 with CD5 and CD117 aids in the diagnosis of this tumor. Aberrant expression of Bcl-2, p53, p16, E-cadherin, EGFR, C-KIT, and HER-2 may play important roles in the development of CASTLE. PMID: 25596248 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Wang YF, Liu B, Fan XS, Rao Q, Xu Y, Xia QY, Yu B, Shi SS, Zhou XJ Tags: Am J Clin Pathol Source Type: research

A hybrid approach to urine drug testing using high-resolution mass spectrometry and select immunoassays.
CONCLUSIONS: The hybrid approach to urine drug testing provides a simplified and analytically specific testing process that minimizes the need for secondary confirmation. PMID: 25596249 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: McMillin GA, Marin SJ, Johnson-Davis KL, Lawlor BG, Strathmann FG Tags: Am J Clin Pathol Source Type: research

Laboratory measurements of the oral direct factor xa inhibitor edoxaban: comparison of prothrombin time, activated partial thromboplastin time, and thrombin generation assay.
CONCLUSIONS: PT had disadvantages of a large variability among different PT reagents. aPTT could be used as a conventional and convenient test with a smaller variation among reagents. Thrombin generation was the most sensitive assay. PMID: 25596250 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Morishima Y, Kamisato C Tags: Am J Clin Pathol Source Type: research

Enhanced FHL2 and TGF-β1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas.
CONCLUSIONS: Enhanced FHL2 and TGF-β1 expression is correlated with poor survival in human malignant melanoma. Protumorigenic effects of autocrine TGF-β1 secretion might be exerted by induction of FHL2 expression in melanoma cells. Since melanomas treated with targeted therapies often do not show sufficient response rates, inhibition of FHL2 and/or TGF-β1 might be a promising therapeutic approach. PMID: 25596251 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 23, 2015 Category: Pathology Authors: Westphal P, Mauch C, Florin A, Czerwitzki J, Olligschläger N, Wodtke C, Schüle R, Büttner R, Friedrichs N Tags: Am J Clin Pathol Source Type: research