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Academic laboratory medicine at 50 years and getting stronger.
PMID: 25873490 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Rinder HM Tags: Am J Clin Pathol Source Type: research

Decreasing inappropriate laboratory test utilization: controlling costs and improving quality of care.
PMID: 25873491 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

Searching for CALRity in Myeloproliferative Neoplasms.
PMID: 25873492 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Cook JR Tags: Am J Clin Pathol Source Type: research

Positive surgical margins in renal cell carcinoma: translating tumor biology into clinical outcomes.
PMID: 25873493 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Picken MM, Wang L, Gupta GN Tags: Am J Clin Pathol Source Type: research

Reducing duplicate testing: a comparison of two clinical decision support tools.
CONCLUSIONS: Structural and process changes that require laboratory contact and justification for duplicate testing are more effective than interventions that allow providers to bypass alerts without justification at point of computerized physician order entry. PMID: 25873494 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Procop GW, Keating C, Stagno P, Kottke-Marchant K, Partin M, Tuttle R, Wyllie R Tags: Am J Clin Pathol Source Type: research

Impact of a prospective review program for reference laboratory testing requests.
CONCLUSIONS: Formal prospective review of reference laboratory testing requests resulted in substantial cost containment and improved the efficiency of patient care. PMID: 25873495 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Greenblatt MB, Nowak JA, Quade CC, Tanasijevic M, Lindeman N, Jarolim P Tags: Am J Clin Pathol Source Type: research

CALR, JAK2, and MPL Mutation Profiles in Patients With Four Different Subtypes of Myeloproliferative Neoplasms: Primary Myelofibrosis, Essential Thrombocythemia, Polycythemia Vera, and Myeloproliferative Neoplasm, Unclassifiable.
CONCLUSIONS: The prognostic significance of CALR mutations likely differs among the MPN subtypes. PMID: 25873496 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Kim SY, Im K, Park SN, Kwon J, Kim JA, Lee DS Tags: Am J Clin Pathol Source Type: research

Partial nephrectomy for renal tumors: lack of correlation between margin status and local recurrence.
CONCLUSIONS: A literature review of 3,803 cases, including our study, shows positive margins in 173, of which 13 recurred; however, 39 with negative margins also recurred. A positive margin in PN seldom correlates with a local recurrence. However, protection from recurrence is not ensured by a negative margin. PMID: 25873497 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Antic T, Taxy JB Tags: Am J Clin Pathol Source Type: research

Evaluation of multiple real-time PCR tests on nasal samples in a large MRSA surveillance program.
CONCLUSIONS: Our results suggest that the performance of the three commercial assays is similar. When assessing economic cost benefit of methicillin-resistant Staphylococcus aureus screening, the two measures with the most impact are the cost of the test and the specificity of the assay results. PMID: 25873498 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Patel PA, Robicsek A, Grayes A, Schora DM, Peterson KE, Wright MO, Peterson LR Tags: Am J Clin Pathol Source Type: research

Significance of paneth cell metaplasia in barrett esophagus: a morphologic and clinicopathologic study.
CONCLUSIONS: The presence of PCM is associated with less disease regression and is not associated with more disease progression. PMID: 25873500 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Chen W, Frankel WL, Cronley KM, Yu L, Zhou X, Yearsley MM Tags: Am J Clin Pathol Source Type: research

Extensive Survey of STAT6 Expression in a Large Series of Mesenchymal Tumors.
CONCLUSIONS: Strong nuclear STAT6 is largely specific for SFTs. Physiologic low-level cytoplasmic/nuclear expression is common in mesenchymal neoplasia and is of uncertain significance. PMID: 25873501 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Demicco EG, Harms PW, Patel RM, Smith SC, Ingram D, Torres K, Carskadon SL, Camelo-Piragua S, McHugh JB, Siddiqui J, Palanisamy N, Lucas DR, Lazar AJ, Wang WL Tags: Am J Clin Pathol Source Type: research

Indirect estimation of pediatric between-individual biological variation data for 22 common serum biochemistries.
CONCLUSIONS: These data are comparable to those reported by the Canadian Laboratory Initiative on Pediatric Reference Intervals study and the Ricos database for adults. This study reports the CVg trends and data for boys and girls by year of age, which have not been described previously. PMID: 25873502 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Loh TP, Metz MP Tags: Am J Clin Pathol Source Type: research

Detection and genotype of high-risk human papillomavirus in fine-needle aspirates of patients with metastatic squamous cell carcinoma is helpful in determining tumor origin.
CONCLUSIONS: HR-HPV detection and genotyping can be performed on lymph node FNAs with metastatic squamous cell carcinoma using the Roche cobas 4800 system. The presence of HR-HPV and/or HPV 16 is a reliable indicator of the metastatic squamous cell carcinoma originating from the oropharynx. PMID: 25873503 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Baldassarri R, Aronberg R, Levi AW, Yarbrough WG, Kowalski D, Chhieng D Tags: Am J Clin Pathol Source Type: research

Malignant effusions correlate with poorer prognosis in patients with diffuse large B-cell lymphoma.
CONCLUSIONS: Patients who have DLBCL with lymphomatous effusions have a poor prognosis and should be treated as having stage IV disease. The analysis of effusions for tumor cells would be a useful addition to the routine workup. PMID: 25873505 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Chen YP, Huang HY, Lin KP, Medeiros LJ, Chen TY, Chang KC Tags: Am J Clin Pathol Source Type: research

B-ALL Minimal Residual Disease Flow Cytometry: An Application of a Novel Method for Optimization of a Single-Tube Model.
CONCLUSIONS: Constructing a flow cytometry panel using a rigorous, objective, quantitative method permits optimization and avoids problems of interdependence and redundancy in a large, multiantigen panel. PMID: 25873506 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Shaver AC, Greig BW, Mosse CA, Seegmiller AC Tags: Am J Clin Pathol Source Type: research

Increased Levels of Tumor Necrosis Factor-α Involved in Rituximab-Related Acute Pulmonary Fibrosis in Diffuse Large B-Cell Lymphoma.
CONCLUSIONS: We observe that increased TNF-α levels may be involved in rituximab-related acute pulmonary fibrosis. PMID: 25873507 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Zhang X, Guo X, Pan J Tags: Am J Clin Pathol Source Type: research

Primary rhabdomyosarcoma of the pineal gland.
CONCLUSIONS: Pineal RMS is a rare disease with poor prognosis. Optimal management is unknown but likely to involve aggressive multimodality therapy. PMID: 25873508 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Lau SK, Cykowski MD, Desai S, Cao Y, Fuller GN, Bruner J, Okazaki I Tags: Am J Clin Pathol Source Type: research

Myocardial changes in a patient with anorexia nervosa: a case report and review of literature.
CONCLUSIONS: The gross findings in the heart correlate with the previously described anomalies on cardiac ultrasound of patients with AN. The fibrosis and myxoid material deposition might be a direct consequence of starvation and the mechanism of death in some patients with AN. PMID: 25873509 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Lamzabi I, Syed S, Reddy VB, Jain R, Harbhajanka A, Arunkumar P Tags: Am J Clin Pathol Source Type: research

Myeloid and Lymphoid Neoplasm With Abnormalities of FGFR1 Presenting With Trilineage Blasts and RUNX1 Rearrangement: A Case Report and Review of Literature.
CONCLUSIONS: To our knowledge, this is the first reported case of a myeloid and lymphoid neoplasm with abnormalities of FGFR1 with t(17;21)(p13;q22) and trilineage blasts. PMID: 25873510 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Kumar KR, Chen W, Koduru PR, Luu HS Tags: Am J Clin Pathol Source Type: research

Clinicocytopathologic correlation in an atypical presentation of lymphadenopathy with review of literature.
CONCLUSIONS: The cytologic findings of CSD in an atypical abdominal presentation are similar to those of a classic presentation. Laboratory workup for atypical CSD should include at least two other modalities aside from cytomorphologic features. Close clinical and cytologic correlation avoided potentially unnecessary and harmful surgery and enabled timely treatment. PMID: 25873511 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Choi AH, Bolaris M, Nguyen DK, Panosyan EH, Lasky JL, Duane GB Tags: Am J Clin Pathol Source Type: research

Paradoxical bleeding and thrombosis in a patient with afibrinogenemia and fibrinogen mumbai mutation.
CONCLUSIONS: Presence of both bleeding and thrombotic manifestations in a patient with afibrinogenemia in the presence of other associated risk factors warrants a very careful individualized approach in the management of patients with afibrinogenemia. PMID: 25873512 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Authors: Mukaddam A, Patil R, Jadli A, Chandrakala S, Ghosh K, Shetty S Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25873513 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Correction.
Authors: PMID: 25873514 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Evaluation of treponemal serum tests performed on cerebrospinal fluid for diagnosis of neurosyphilis.
CONCLUSIONS: Treponemal serum tests performed on CSF were useful in identifying two patients with nonreactive CSF-VDRL. PMID: 25779998 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Guarner J, Jost H, Pillay A, Sun Y, Cox D, Notenboom R, Workowski K Tags: Am J Clin Pathol Source Type: research

Follow-up Outcomes in a Large Cohort of Patients With HPV-Negative LSIL Cervical Screening Test Results.
CONCLUSIONS: This is the largest study documenting follow-up results for patients with HPV-negative LSIL results based on prevalent US FDA-approved cotesting methods from one collection vial. These data document that risk for follow-up HSILs in these patients is low and also that no cervical cancers were diagnosed. These findings support recent recommendations for repeat cotesting after 1 year as an appropriate option for patients with HPV-negative LSIL results. PMID: 25779999 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Barron S, Austin RM, Li Z, Zhao C Tags: Am J Clin Pathol Source Type: research

Relationship of pathologic factors to efficacy of sorafenib treatment in patients with metastatic clear cell renal cell carcinoma.
CONCLUSIONS: As a novel histologic prognostic parameter, growth pattern may be useful for predicting response to sorafenib treatment. PMID: 25780000 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Araki H, Tsuzuki T, Kimura T, Tanaka K, Yamada S, Sassa N, Yoshino Y, Hattori R, Gotoh M Tags: Am J Clin Pathol Source Type: research

Detection of BRAF Mutations on Direct Smears of Thyroid Fine-Needle Aspirates Through Cell Transfer Technique.
CONCLUSIONS: PCR-based BRAF mutational testing can be reliably performed on the direct smears of the thyroid FNA specimens through the application of CTT. PMID: 25780001 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Shi Q, Ibrahim A, Herbert K, Carvin M, Randolph M, Post KM, Curless K, Chen S, Cramer HM, Cheng L, Wu HH Tags: Am J Clin Pathol Source Type: research

Primary sclerosing cholangitis: detailed histologic assessment and integration using bioinformatics highlights arterial fibrointimal hyperplasia as a novel feature.
CONCLUSIONS: This study demonstrates characteristic PSC histology as well as arterial hyperplasia to be distinctive features that may aid in PSC diagnosis and be confirmed by bioinformatics. PMID: 25780002 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Carrasco-Avino G, Schiano TD, Ward SC, Thung SN, Fiel MI Tags: Am J Clin Pathol Source Type: research

Expression of Bcl-xL and Mcl-1 in the Nonmelanoma Skin Cancers of Renal Transplant Recipients.
CONCLUSIONS: It was shown for the first time that Bcl-xL and Mcl-1 expression are widespread in the peritumoral epidermis and NMSC of renal transplant recipients. Importantly in NMSC, Bcl-xL expression was reduced with immunosuppression exposure, and Mcl-1 expression was reduced in tacrolimus-treated compared with sirolimustreated patients. PMID: 25780003 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Burke MT, Morais C, Oliver KA, Lambie DL, Gobe GC, Carroll RP, Staatz CE, Sinnya S, Soyer HP, Winterford C, Haass NK, Campbell SB, Isbel NM Tags: Am J Clin Pathol Source Type: research

Mast Cells in Systemic Mastocytosis Have Distinctly Brighter CD45 Expression by Flow Cytometry.
CONCLUSIONS: A combination of bright CD45 and CD25 appears to specifically identify abnormal mast cells in cases of systemic mastocytosis. Further studies will be necessary to confirm these results. PMID: 25780004 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Chisholm KM, Merker JD, Gotlib JR, Gitana G, Lefterova M, Zehnder JL, George TI, Arber DA, Ohgami RS Tags: Am J Clin Pathol Source Type: research

Adequacy of Powered vs Manual Bone Marrow Biopsy Specimens: A Retrospective Review of Sequential Marrow Aspirates and Biopsies in 68 Patients.
CONCLUSIONS: Our findings show that longer core biopsy specimens are obtained by the OnControl Bone Marrow system but that the manual method is still superior when the percentage and length of evaluable bone marrow are analyzed. PMID: 25780005 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Lynch DW, Stauffer SL, Rosenthal NS Tags: Am J Clin Pathol Source Type: research

BCL6 Expression Correlates With the t(1;19) Translocation in B-Lymphoblastic Leukemia.
CONCLUSIONS: BCL6 expression is present in a subset of B-lymphoblastic leukemias, especially in cases containing the 1;19 translocation. Investigation for TCF3(E2A)-PBX1 rearrangements may be useful in BCL6-positive B-lymphoblastic leukemia. PMID: 25780007 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Deucher AM, Qi Z, Yu J, George TI, Etzell JE Tags: Am J Clin Pathol Source Type: research

Effect of blood sampling, processing, and storage on the measurement of complement activation biomarkers.
CONCLUSIONS: The results from this study thus provide crucial guidelines for future investigations using complement biomarkers to define the role of complement system in disease. PMID: 25780008 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Yang S, McGookey M, Wang Y, Cataland SR, Wu HM Tags: Am J Clin Pathol Source Type: research

Laboratory quality improvement in Tanzania.
CONCLUSIONS: The article describes the progress made in Tanzania's first cohorts, the obstacles encountered, and the lessons learned during the pilot and subsequent implementations. PMID: 25780009 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Andiric LR, Massambu CG Tags: Am J Clin Pathol Source Type: research

Comparison of next-generation sequencing and mutation-specific platforms in clinical practice.
CONCLUSIONS: Sensitivity for detecting mutations was highly comparable among all platforms. The choice for either a dedicated genotyping platform or an NGS platform is basically a trade-off between speed and genetic information. PMID: 25780010 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Hinrichs JW, Marja van Blokland WT, Moons MJ, Radersma RD, Radersma-van Loon JH, de Voijs CM, Rappel SB, Koudijs MJ, Besselink NJ, Willems SM, de Weger RA Tags: Am J Clin Pathol Source Type: research

Validation of hemolysis index thresholds optimizes detection of clinically significant hemolysis.
CONCLUSIONS: Mean measured potassium concentrations are not clinically significantly affected by hemolysis at the manufacturer-recommended HI threshold, while AST and LDH are. Aligning reporting of sample hemolysis with clinically significant changes provides clinically meaningful alerts regarding this common preanalytic error. PMID: 25780011 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Goyal T, Schmotzer CL Tags: Am J Clin Pathol Source Type: research

Expression of metabolism-related proteins in lacrimal gland adenoid cystic carcinoma.
CONCLUSIONS: Lacrimal gland ACC exhibited higher expression of GLS1 and ASCT2, compared with salivary gland ACC. Overexpression of MCT4, PSPH, and SHMT1 was associated with poorer prognosis. PMID: 25780012 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Koo JS, Yoon JS Tags: Am J Clin Pathol Source Type: research

Dermatopathologists' opinions about the quality of clinical information in the skin biopsy requisition form and the skin biopsy care process: a semiqualitative assessment.
CONCLUSIONS: Dermatopathologists communicated that missing clinical information in the RF and inadequate specimens are common and adversely affect the quality of care. Multiple provider- and practice-related factors contribute to communication failures and deserve further investigation. PMID: 25780013 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Wong C, Peters M, Tilburt J, Comfere N Tags: Am J Clin Pathol Source Type: research

Clinicopathologic Evaluation of MYC Expression in Primary Mediastinal (Thymic) Large B-Cell Lymphoma.
CONCLUSIONS: MYC protein expression by IHC is present in most PMBLs. Increased MYC protein expression can be seen in one-third of the cases; however, it does not correlate with genetic abnormalities by FISH. There is also no significant impact of MYC protein expression on clinical outcomes. PMID: 25780014 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Li KD, Miles R, Tripp SR, Glenn MJ, Perkins SL, Salama M Tags: Am J Clin Pathol Source Type: research

AJCP Journal CME/SAM.
Authors: PMID: 25780015 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Correction.
Authors: PMID: 25780016 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Waste not, want not.
PMID: 25696787 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Hannon T Tags: Am J Clin Pathol Source Type: research

Screening for Lynch Syndrome: A No-Brainer: BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor.
PMID: 25696788 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Bellizzi AM Tags: Am J Clin Pathol Source Type: research

Quality pathology and laboratory diagnostic services are key to improving global health outcomes: improving global health outcomes is not possible without accurate disease diagnosis.
PMID: 25696789 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: African Strategies for Advancing Pathology Group Members Tags: Am J Clin Pathol Source Type: research

Effectiveness of multiple initiatives to reduce blood component wastage.
CONCLUSIONS: Relatively inexpensive interventions can have a prompt and dramatic impact on reducing blood wastage with regard to both cost and resource savings. PMID: 25696790 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Collins RA, Wisniewski MK, Waters JH, Triulzi DJ, Yazer MH Tags: Am J Clin Pathol Source Type: research

A Modified Lynch Syndrome Screening Algorithm in Colon Cancer: BRAF Immunohistochemistry Is Efficacious and Cost Beneficial.
CONCLUSIONS: BRAF V600E IHC was concordant between TMAs, biopsy specimens, and whole-section slides, suggesting biopsy specimens are as useful as whole sections. IHC remained cost beneficial compared with mutational analysis, even though more patients needed additional molecular testing to exclude Lynch syndrome. PMID: 25696791 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Roth RM, Hampel H, Arnold CA, Yearsley MM, Marsh WL, Frankel WL Tags: Am J Clin Pathol Source Type: research

Use of hTERT and HPV E6/E7 mRNA RT-qPCR TaqMan Assays in Combination for Diagnosing High-Grade Cervical Lesions and Malignant Tumors.
CONCLUSIONS: These data suggest that the combination of HPV E6/E7 and hTERT mRNA expression levels could be used in a complementary manner in diagnosing high-grade cervical lesions and malignant tumors and might be useful as a predictive marker in monitoring low-grade cervical lesions. PMID: 25696792 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Wang HY, Park S, Kim S, Lee D, Kim G, Kim Y, Park KH, Lee H Tags: Am J Clin Pathol Source Type: research

Effects of levonorgestrel-releasing intrauterine system on lymphangiogenesis of adenomyosis.
CONCLUSIONS: Treatment with the LNG-IUS resulted in reduced lymphangiogenesis and LVD in the endometrial and myometrial tissues of patients with adenomyosis. Reduced lymphangiogenesis may be one mechanism by which the LNG-IUS reduces adenomyosis-related symptoms. PMID: 25696793 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Cho S, Choi YS, Yun BH, Chon SJ, Jung YS, Kim HY, Park JH, Seo SK, Kim SH, Lee BS Tags: Am J Clin Pathol Source Type: research

Diagnostic and Prognostic Value of BCL2 Rearrangement in 53 Patients With Follicular Lymphoma Presenting as Primary Skin Lesions.
CONCLUSIONS: We observed that BCL2 rearrangement in PCFCL is rare, associated with initial positivity of staging (diagnostic value) or with secondary extracutaneous spreading (prognostic value). In selected cases with BCL2-CD10 coexpression, FISH testing could detect patients with poor outcome and require closer monitoring. PMID: 25696794 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Pham-Ledard A, Cowppli-Bony A, Doussau A, Prochazkova-Carlotti M, Laharanne E, Jouary T, Belaud-Rotureau MA, Vergier B, Merlio JP, Beylot-Barry M Tags: Am J Clin Pathol Source Type: research

Left-Sided Early-Onset vs Late-Onset Colorectal Carcinoma: Histologic, Clinical, and Molecular Differences.
CONCLUSIONS: Our results suggest that left-sided CRCs may present differential patterns of aberrant DNA methylation when they are separated by age. PMID: 25696795 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2015 Category: Pathology Authors: Pilozzi E, Maresca C, Duranti E, Giustiniani MC, Catalanotto C, Lucarelli M, Cogoni C, Ferri M, Ruco L, Zardo G Tags: Am J Clin Pathol Source Type: research