Risk factors for a severe course of COVID-19 in people with diabetes
(Deutsches Zentrum fuer Diabetesforschung DZD) People with diabetes are at increased risk of developing a severe course of COVID-19 compared to people without diabetes. The question to be answered is whether all people with diabetes have an increased risk of severe COVID-19, or whether specific risk factors can also be identified within this group. A new study by DZD researchers has now focused precisely on this question and gained relevant insights.
Source: EurekAlert! - Infectious and Emerging Diseases - April 29, 2021 Category: Infectious Diseases Source Type: news

New targets for the development of a drug treatment for obesity and type 2 diabetes
(Deutsches Zentrum fuer Diabetesforschung DZD) The GIP receptor in the central nervous system plays a crucial role in the regulation of body weight and food intake. This is shown by a recent study by Helmholtz Zentrum M ü nchen, ETH Zurich and the German Center for Diabetes Research (DZD). The study, which has now been published in 'Cell Metabolism', identifies new targets for the development of a drug treatment for obesity and type 2 diabetes.
Source: EurekAlert! - Medicine and Health - February 10, 2021 Category: International Medicine & Public Health Source Type: news

The interconnection of global pandemics -- Obesity, impaired metabolic health and COVID-19
(Deutsches Zentrum fuer Diabetesforschung DZD) In a Nature Reviews Endocrinology article authors from the German Center for Diabetes Research (DZD) highlight the interconnection of #obesity and impaired metabolic health with the severity of #COVID19. #diabetes
Source: EurekAlert! - Medicine and Health - January 21, 2021 Category: International Medicine & Public Health Source Type: news

Prediabetes subtypes identified
(Deutsches Zentrum fuer Diabetesforschung DZD) All prediabetes is not the same: in people in the preliminary stages of type 2 diabetes, there are six clearly distinguishable subtypes, which differ in the development of the disease, diabetes risk, and the development of secondary diseases. The new classification can help in the future to prevent the manifestation of diabetes or the development of diabetes complications through targeted prevention.
Source: EurekAlert! - Medicine and Health - January 4, 2021 Category: International Medicine & Public Health Source Type: news

Epigenetic changes precede onset of diabetes
(Deutsches Zentrum fuer Diabetesforschung DZD) Epigenetic* changes in the islets of Langerhans of the pancreas can be detected in patients several years before the diagnosis of type 2 diabetes. These changes are responsible for the altered methylation activity of specific genes which differs from that in healthy individuals. In humans, 105 such changes have been discovered in blood cells. This was shown in a study by researchers from the DZD/DIfE, which has now been published in the journal Diabetes.
Source: EurekAlert! - Medicine and Health - September 10, 2020 Category: International Medicine & Public Health Source Type: news

A gatekeeper against insulin resistance in the brain
(Deutsches Zentrum fuer Diabetesforschung DZD) The brain plays a major role in controlling our blood glucose levels. In type 2 diabetes this glucose metabolism brain control is often dysfunctional. A group of scientists at Helmholtz Zentrum M ü nchen and the German Center for Diabetes Research (DZD) have now shown in the 'Journal of Clinical Investigations' that in men a genetic variant of the gene DUSP8 can increase the risk for T2D by impairing our brain response to the hormone insulin.
Source: EurekAlert! - Biology - August 21, 2020 Category: Biology Source Type: news

Summary of preliminary data about obesity and severity of COVID-19
(Deutsches Zentrum fuer Diabetesforschung DZD) In a Nature Reviews Endocrinology 'Comment' authors from the German Center for Diabetes Research (DZD), the Boston Children's Hospital and the Harvard T.H. Chan School of Public Health call for more research about the relationships of obesity, disproportionate fat distribution and impaired metabolic health with the severity of COVID-19.
Source: EurekAlert! - Medicine and Health - April 24, 2020 Category: International Medicine & Public Health Source Type: news

Brain insulin sensitivity determines body weight and fat distribution
(Deutsches Zentrum fuer Diabetesforschung DZD) Just where fat is deposited in the body and to what degree a person may benefit from a lifestyle intervention depends on how sensitive the brain is to insulin. If the person's brain responds sensitively to the hormone, a significant amount of weight can be lost and unhealthy visceral fat. People with brain insulin resistance only showed a slight weight loss. These are the results of a long-term study.
Source: EurekAlert! - Medicine and Health - April 24, 2020 Category: International Medicine & Public Health Source Type: news

New contrast agent for early diagnosis of brain metastases
(Forschungsverbund Berlin) A group of researchers led by Leif Schroeder from the Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie (FMP) have found a way to detect metastases in certain types of cancer in the brain at an early stage, using only minimal amounts of contrast agent. To this end, the team uses a synthetic molecule that helps to detect the formation of new blood vessels, producing much more sophisticated imaging than is possible with conventional methods of diagnosis.
Source: EurekAlert! - Cancer - March 19, 2020 Category: Cancer & Oncology Source Type: news

Promising approach: Prevent diabetes with intermittent fasting
(Deutsches Zentrum fuer Diabetesforschung DZD) Intermittent fasting is known to improve sensitivity to the blood glucose-lowering hormone insulin and to protect against fatty liver. DZD scientists from DIfE have now discovered that mice on an intermittent fasting regimen also exhibited lower pancreatic fat. In their current study published in the journal Metabolism, the researchers showed the mechanism by which pancreatic fat could contribute to the development of type 2 diabetes.
Source: EurekAlert! - Medicine and Health - July 2, 2019 Category: International Medicine & Public Health Source Type: news

The Lypla1 gene impacts obesity in a sex-specific manner
(Deutsches Zentrum fuer Diabetesforschung DZD) Susceptibility to obesity, insulin resistance and other cardio-metabolic traits may also be dependent on a person's sex. An international research team studied sex differences and sex-specific interaction with the genetic background in cardio-metabolic phenotypes. The researchers discovered, among other things, a sex-specific obesity locus of the Lypla1 gene, which is associated with human obesity. The results of the study have now been published in Cell Metabolism.
Source: EurekAlert! - Medicine and Health - February 15, 2019 Category: International Medicine & Public Health Source Type: news

Novel concepts for the diagnosis of fatty liver and personalized treatment
(Deutsches Zentrum fuer Diabetesforschung DZD) Almost one in three adults suffer from non-alcoholic fatty liver. For the affected people this increases the risk of complications such as liver cancer, diabetes, high blood pressure and stroke. In a review article in The Lancet Diabetes& Endocrinology, Nobert Stefan and Hans-Ulrich H ä ring from the DZD and Kenneth Cusi from the University of Florida summarize current research findings and show how this knowledge can be used for personalized risk prognosis and individualized treatment.
Source: EurekAlert! - Medicine and Health - August 31, 2018 Category: International Medicine & Public Health Source Type: news

A matter of dynamics
(Forschungsverbund Berlin) Most ion channels are very selective about the ions, which may or may not pass through them. They may be conductive for potassium ions and non-conductive for sodium ions or vice versa. However, a number of ion channels allows for the efficient passage of both kinds of ions. Scientists at the Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie found the answer to this question. Their study revealed structural and dynamic differences between selective and non-selective ion channels.
Source: EurekAlert! - Medicine and Health - February 20, 2018 Category: International Medicine & Public Health Source Type: news

Prostate cancer: Poor prognosis in men with diabetes
(Deutsches Zentrum fuer Diabetesforschung DZD) Men with type 2 diabetes are less likely to develop prostate cancer than patients without diabetes. However, the mortality rate is higher. Researchers were able to show that in the affected individuals the androgen receptor and the mitogenic forms of the insulin receptor were more strongly expressed. This could explain why patients with diabetes have a poorer prognosis for prostate cancer.
Source: EurekAlert! - Medicine and Health - January 31, 2018 Category: International Medicine & Public Health Source Type: news

Diabetes-related mortality in Germany higher than expected
(Deutsches Zentrum fuer Diabetesforschung DZD) In Germany, nationwide data on mortality attributable to diagnosed diabetes are not available. Researchers at the German Diabetes Center (DDZ) in D ü sseldorf have now calculated that a total of around 175,000 deaths were associated with diabetes in 2010. The result of the analysis shows that far more people in Germany die from diabetes and its complications than is stated in the official statistics on cause of death.
Source: EurekAlert! - Social and Behavioral Science - November 21, 2017 Category: International Medicine & Public Health Source Type: news

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