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Investigation of intercalation of diphenhydramine into the interlayer of smectite by XRD, FTIR, TG-DTG analyses and molecular simulation
In this study the intercalation of DPH in the interlayer of a Ca-smectite was characterized by X-ray diffraction, infra-red, and thermogravimetric analyses supported by molecular dynamic simulation. At the low (0.2–0.3 CEC) and high (0.6–0.7 CEC) adsorption levels, the intercalated DPH might take a horizontal monolayer or a bilayer configuration, resulting in a d001 expansion to 15 or 17 Å, respectively. As the amount of DPH intercalation increased, a gradual, yet systematic, dehydration due to removal of hydrated inorganic cation Ca2+ from the interlayer was observed. In addition, the intercalated DPH had a slightly ...
Source: Arabian Journal of Chemistry - April 25, 2015 Category: Chemistry Source Type: research
Intramolecular interactions contributing for the conformational preference of bioactive diphenhydramine: Manifestation of the gauche effect
Publication date: 5 August 2015 Source:Journal of Molecular Structure, Volume 1093 Author(s): Fátima M.P. de Rezende , Laize A.F. Andrade , Matheus P. Freitas Diphenhydramine is an antihistamine used to treat some symptoms of allergies and the common cold. It is usually marketed as the hydrochloride salt, and both the neutral and cation forms have the O–C–C–N fragment. The gauche effect is well known in fluorine-containing chains, because its main origin is hyperconjugative and the σ∗ C–F is a low-lying acceptor orbital, allowing electron delocalization in the conformation where F and an adjacent electronegat...
Source: Journal of Molecular Structure - April 22, 2015 Category: Molecular Biology Source Type: research
Enhanced Fenton-like degradation of pharmaceuticals over framework copper species in copper-doped mesoporous silica microspheres
Publication date: 15 August 2015 Source:Chemical Engineering Journal, Volume 274 Author(s): Lai Lyu , Lili Zhang , Chun Hu Copper-doped mesoporous silica microspheres (Cu-MSMs) with the coexistence of Cu(I) and Cu(II) were prepared using a hydrothermal process and characterized by several methods. The characterization studies suggested that 0.91wt% of the copper species could exist in the framework of the mesoporous silica microspheres by chemical binding of SiOCu; excess copper species were located in the extraframework sites, leading to more oxygen vacancies on the surface of the catalysts. The framework Cu of Cu-MSMs ...
Source: Chemical Engineering Journal - April 20, 2015 Category: Chemistry Source Type: research
Synthesis of pH-sensitive poly (N,N-dimethylaminoethyl methacrylate)-grafted halloysite nanotubes for adsorption and controlled release of DPH and DS drugs
Publication date: 18 May 2015 Source:Polymer, Volume 65 Author(s): Hamoon Hemmatpour , Vahid Haddadi-Asl , Hossein Roghani-Mamaqani Halloysite nanotube (HNT) was functionalized with (3-Aminopropyl)triethoxysilane (APTES), alpha-bromoisobutyryl bromide (BiBB), and poly (N,N-dimethylaminoethyl methacrylate) (PDMAEMA) chains. Successful grafting of PDMAEMA by SI-ATRP method was evaluated by XPS, FTIR, TEM, and TGA. Pore volume studies were accomplished by BET, and XRD was used to study crystalline structure of nanotubes. PDMAEMA coverage is formed on the outer and inner surface and also lumen of nanotubes. Sensitivity of PD...
Source: Polymer - April 17, 2015 Category: Chemistry Source Type: research
Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model.
Authors: Higuchi K, Kitamura A, Okura T, Deguchi Y Abstract Memantine is clinically used for the treatment of patients with Alzheimer's disease and is highly distributed to the brain. The aim of this study is to characterize memantine transport at the blood-brain barrier (BBB) using hCMEC/D3 cells, a human BBB model. The initial uptake velocity of memantine in hCMEC/D3 cells was concentration-dependent, and was reduced by metabolic inhibitors, but was independent of extracellular sodium ion and membrane potential. Intracellular alkalization and intracellular acidification markedly reduced and enhanced the uptake, r...
Source: Drug Metabolism and Pharmacokinetics - April 12, 2015 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
Effect of sodium chloride and myo-inositol on diphenhydramine hydrochloride drug in aqueous solution at different temperatures: Volumetric and acoustic approach
Publication date: August 2015 Source:The Journal of Chemical Thermodynamics, Volume 87 Author(s): Santosh P. Jengathe , Sudhakar S. Dhondge , Lalitmohan J. Paliwal , Vijay M. Tangde , Sudip Mondal Densities and speeds of sound of diphenhydramine hydrochloride (DPH) in aqueous solution and 0.06mol·kg−1 aqueous solutions of sodium chloride and myo-inositol (MI) have been measured at different temperatures, T =(288.15, 298.15 and 308.15)K over the concentration range (0.01 to 0.1)mol·kg−1. Density and speed of sound values were used to evaluate thermodynamic properties such as apparent molar volume (Vϕ ), isentropic ...
Source: The Journal of Chemical Thermodynamics - April 9, 2015 Category: Chemistry Source Type: research
Dosing, Side Effects, and Long-Term Outcomes for IVIg Use in Treatment of Neurological Conditions: Data from the Immunoglobulin Diagnosis, Evaluation, and key Learnings (IDEaL) Patient Registry (P6.036)
CONCLUSIONS: The data presented provides information on IVIg dosing for neurological subjects, and indicates that most patients did not report side effects from their IVIg therapy. The quality-of-life and outcomes data show improvements in overall physical function scores as well as in acute symptoms for patients receiving IVIg therapy. Study Supported by:Disclosure: Dr. Kearns has received personal compensation for activities with Coram Clinical Trials as an employee. Dr. Kristofek has received personal compensation for activities with Coram Clinical Trials as an employee. Dr. Bolgar has received personal compensation for...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kearns, S., Kristofek, L., Bolgar, B., Seidu, L. Tags: Neurotherapeutics Source Type: research
Occurrences of pharmaceuticals in drinking water sources of major river watersheds, China.
In this study, a survey for multi-class pharmaceuticals in DWSs of five major river watersheds in China was conducted from 2012 to 2013. Samples were collected from 25 sampling sites in rivers and reservoirs. 135 pharmaceuticals were analyzed using solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry. The results showed that a total of 70 pharmaceuticals were present in the samples, and the most frequently detected ones included sulfonamides, macrolides, antiepileptic drugs, anti-inflammatory drugs, and β-blockers, etc. Amongst these, maximum concentrations of lincomycin, sulfamethox...
Source: Ecotoxicology and Environmental Safety - April 3, 2015 Category: Environmental Health Authors: Sun J, Luo Q, Wang D, Wang Z Tags: Ecotoxicol Environ Saf Source Type: research
Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model.
Abstract In order to bridge the gap of action of dl-sotalol between the human ether-a-go-go-related gene (hERG) K(+) channel inhibition in vitro and QT-interval prolongation in vivo, its electropharmacological effect and pharmacokinetic property were simultaneously studied in comparison with those of 10 drugs having potential to prolong the QT interval (positive drugs: bepridil, haloperidol, dl-sotalol, terfenadine, thioridazine, moxifloxacin, pimozide, sparfloxacin, diphenhydramine, imipramine and ketoconazole) and four drugs lacking such property (negative drugs: enalapril, phenytoin, propranolol or verapamil) wi...
Source: Cardiovascular Toxicology - March 31, 2015 Category: Cardiology Authors: Katagi J, Nakamura Y, Cao X, Ohara H, Honda A, Izumi-Nakaseko H, Ando K, Sugiyama A Tags: Cardiovasc Toxicol Source Type: research
The Impact of Chronic Opioid Use on Colonoscopy Outcomes
Conclusion Patients on chronic opioids represent a high-risk population with longer procedural times and more discomfort, despite higher dosages of sedative agents. Prospective studies are required to define the risks and benefits of more costly alternative sedation strategies for patients on chronic opioids. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 31, 2015 Category: Gastroenterology Source Type: research
Concurrent quantification and comparative pharmacokinetic analysis of bioactive compounds in the Herba Ephedrae-Semen Armeniacae Amarum herb pair
Publication date: 10 May 2015 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 109 Author(s): Shuai Song , Feilong Chen , Xuefeng Xing , Mengyue Ren , Qinhai Ma , Ying Xie , Qingfa Tang , Jiabo Luo The Mahuang–Xingren herb-pair (MX), the combination of Herba Ephedrae (Mahuang in Chinese) and Semen Armeniacae Amarum (Xingren in Chinese), is a classical combination used in traditional Chinese Medicine to treat asthma and bronchitis. A simple and reliable ultra-performance liquid chromatography-tandem mass spectrometry method was developed to simultaneously quantify and compare the pharmacokinetics of 5 ep...
Source: Journal of Pharmaceutical and Biomedical Analysis - March 28, 2015 Category: Drugs & Pharmacology Source Type: research
Impact of Computerized Physician Order Entry Alerts on Prescribing in Older Patients
Conclusion The data suggest that prescribing rates for drugs with the least efficacy and potential for harm and with alternative agents (i.e., diphenhydramine and metoclopramide) can be modified by CPOE alerts for older patients. (Source: Drugs and Aging)
Source: Drugs and Aging - March 10, 2015 Category: Geriatrics Source Type: research
Adrenal renal fusion confusion: a case report of an adrenal cortical adenoma with adrenal–renal fusion
We report a case of laminaria hypersensitivity treated with diphenhydramine and corticosteroids. A literature review identified 10 previously reported cases, with 8 recognized as anaphylaxis, and good outcomes with corticosteroids and antihistamines despite limited epinephrine utilization. Laminaria hypersensitivity is likely IgE mediated with an increased anaphylaxis risk with prior exposure. (Source: Clinical Imaging)
Source: Clinical Imaging - March 7, 2015 Category: Radiology Authors: Shannon St. Clair, Stephen Machnicki, Alyssa Yurovitsky Tags: Case Report Source Type: research
An ultrasensitive electrochemiluminescence sensor for detecting diphenhydramine hydrochloride based on l-cysteine-functionalized multiwalled carbon nanotubes/gold nanoparticles nanocomposites
Publication date: 5 July 2015 Source:Sensors and Actuators B: Chemical, Volume 213 Author(s): Chongchong Miao , Amin Zhang , Yanan Xu , Shen Chen , Feimeng Ma , Chusen Huang , Nengqin Jia A new electrochemiluminescence (ECL) sensor was constructed for the ultrasensitive detection of diphenhydramine hydrochloride (DPH) based on l-cysteine-functionalized multiwalled carbon nanotubes/gold nanoparticles (MWCNTs-Cys-AuNPs) nanocomposites. In this work, the nanocomposites were facilely synthesized by using l-cysteine as linking agent which could covalently conjugate to MWCNTs and AuNPs via amide bond and AuS bond. Herein, the ...
Source: Sensors and Actuators B: Chemical - March 5, 2015 Category: Chemistry Source Type: research
Aspirin use associated with amyotrophic lateral sclerosis: a total population-based case-control study.
CONCLUSIONS: The results of this study suggested that aspirin use might reduce the risk of ALS, and the benefit might be more prominent for older people. PMID: 25721071 [PubMed - in process] (Source: Journal of Epidemiology)
Source: Journal of Epidemiology - March 2, 2015 Category: Epidemiology Tags: J Epidemiol Source Type: research
The Effect of Diphenhydramine on Sleep in Pediatric Burn Patients: A Secondary Analysis
Adequate sleep is essential for maintaining homeostasis, especially when recovering from an illness; however, studies have shown that sleep disruption and sleep deprivation are common in intensive care unit patients, including children who have sustained burn injury. The purpose of this study was to evaluate the effect of diphenhydramine (DPH) on sleep in pediatric intensive care unit burn patients using Myra Levine’s Conservation Model as the organizing framework. For this study, secondary analysis of polysomnography data and retrospective chart review were used. Twelve DPH patients were pair matched in terms of morphin...
Source: Journal of Burn Care and Research - February 28, 2015 Category: Rehabilitation Tags: Original Articles Source Type: research
Case Presentation: Trick or Treat?
The Monday morning staff meeting was beginning when a school-aged child and his mother walked up to the glass door. Although the clinic had not opened, upon seeing the child's startling appearance, the four nurse practitioners (NPs) sprang into action. His face was red and severely swollen, his lips were twice normal size, and his eyes were nearly swollen shut (Figure). One NP retrieved the oxygen tank, another reached for the EpiPen, and the third readied the diphenhydramine. The NP at the door talked to the child and assessed his breath sounds. (Source: Journal of Pediatric Health Care)
Source: Journal of Pediatric Health Care - February 21, 2015 Category: Pediatrics Authors: Nan Gaylord, Tami Bland Tags: Department Source Type: research
Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection
Conclusions: Our results provide the initial evidence of the ability of diphenhydramine to inhibit cough reflex sensitivity in subjects with acute pathological cough. Timing of cough reflex sensitivity measurement may not have allowed demonstration of maximal antitussive effect of dextromethorphan. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - February 12, 2015 Category: Drugs & Pharmacology Source Type: research
Ionic Fluids Containing Both Strongly and Weakly Interacting Ions of the Same Charge Have Unique Ionic and Chemical Environments as a Function of Ion Concentration.
Abstract Liquid multi-ion systems made by combining two or more salts can exhibit charge ordering and interactions not found in the parent salts, leading to new sets of properties. This is investigated herein by examining a liquid comprised of a single cation, 1-ethyl-3-methylimidazolium ([C2 mim](+) ), and two anions with different properties, acetate ([OAc](-) ) and bis(trifluoromethylsulfonyl)imide ([NTf2 ](-) ). NMR and IR spectroscopy indicate that the electrostatic interactions are quite different from those in either [C2 mim][OAc] or [C2 mim][NTf2 ]. This is attributed to the ability of [OAc](-) to form comp...
Source: Chemphyschem - February 4, 2015 Category: Chemistry Authors: Wang H, Kelley SP, Brantley JW, Chatel G, Shamshina J, Pereira JF, Debbeti V, Myerson AS, Rogers RD Tags: Chemphyschem Source Type: research
A Comparison of Acute Treatment Regimens for Migraine in the Emergency Department
CONCLUSIONS: The majority of children with migraines are successfully discharged from the ED and only 1 in 18 required a revisit within 3 days. Prochlorperazine appears to be superior to metoclopramide in preventing a revisit, and diphenhydramine use is associated with increased rates of return. (Source: PEDIATRICS)
Source: PEDIATRICS - February 2, 2015 Category: Pediatrics Authors: Bachur, R. G., Monuteaux, M. C., Neuman, M. I. Tags: Correction Article Source Type: research
A Comparison of Acute Treatment Regimens for Migraine in the Emergency Department
Migraine headaches are a common presenting complaint in emergency departments. Abortive treatment in this setting is not well studied, leading to considerable variation in treatment. The relationship between acute medications and emergency department revisits has not been studied. Eighty-five percent of children with migraine are successfully discharged from the emergency department; only 1 in 18 children require a return visit. Prochlorperazine is associated with less revisits than metoclopramide, and diphenhydramine use is associated with increased risk of return visits. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - February 2, 2015 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research
Deep Brain Stimulation In The Treatment OF Tardive Dyskinesia
We report a case a patient who suffered severe tardive dyskinesia which was resistant to change of medication, and the use of Cogentin, Benadryl or Botulinum toxin injections to alleviate her symptoms. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Puri, A. Albassam Source Type: research
Desensitization to ceftaroline in a patient with multiple medication hypersensitivity reactions.
CONCLUSION: Desensitization to ceftaroline was conducted for a patient with extensive history of hypersensitivity reactions to other drugs, including penicillin-induced anaphylaxis. Desensitization and subsequent treatment with full doses of ceftaroline were accomplished without apparent adverse effects. PMID: 25596602 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - January 27, 2015 Category: Drugs & Pharmacology Authors: Jones JM, Richter LM, Alonto A, Leedahl DD Tags: Am J Health Syst Pharm Source Type: research
Show Me the Evidence: Is the Routine Use of Premedication for Transfusion Really Necessary?
Improvements in transfusion medicine, blood typing, and donor screening have reduced the likelihood of a reaction from administration of blood products. In an effort to prevent transfusion reactions, our current standard is to administer acetaminophen 650mg and diphenhydramine 25mg, 30 minutes before transfusions. This practice may unnecessarily place patients at increased risk for complications including falls, cognitive impairment, and hepatic toxicity. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Julie Schutte, Ashlee Kwiatkowski, Jim Wischmeier, Sherry Amelung, Valerie Dougherty, Greg Voelkel, Eve Weber, Susan Hankins, Megan Colburn, Cheryl Wilson, Rebekah Flynn, Joyce Divanbeigi, Chris Rimkus Tags: Transplant Nursing Research Source Type: research
Massive attack by honeybees in a German shepherd dog: description of a fatal case and review of the literature
In the present study, a fatal case caused by honeybee (Apis cerana) stings was documented in a female German shepherd dog that was presented at the Veterinary Teaching Hospital, University of Agriculture Faisalabad, Pakistan. Characteristic clinical signs included hematuria, hematemesis, incoordination and convulsions along with evidence of massive honeybee attack supported the diagnosis of envenomation. The dog was treated with dexamethasone and diphenhydramine, but it did not respond to therapy and died. This outcome could be avoided if we had a bee antivenom available for treating envenomated patients. (Source: Journal ...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - January 23, 2015 Category: Tropical Medicine Source Type: research
Saving two lives with one dialysis treatment Successful treatment of life threatening diphenhydramine intoxication by intermittent hemodialysis using a high cut-off membrane.
We present a potentially lifethreatening diphenhydramine (DPH) overdose in a stuporous female patient in which high cut-off hemodialysis was used. Timely detoxification resulted in rapid gain of consciousness, allowing the patient to state the existence and location of another poison victim. PMID: 25600858 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 20, 2015 Category: Urology & Nephrology Authors: Baroke E, Schmidt JJ, Strunk AK, Wiesner O, Kühn-Velten WN, Kielstein JT Tags: Clin Nephrol Source Type: research
Double-blind, randomized, controlled, crossover trial of pregabalin for neurogenic claudication
Conclusions: Pregabalin was not more effective than active placebo in reducing painful symptoms or functional limitations in patients with neurogenic claudication associated with lumbar spinal stenosis. Classification of evidence: This study provides Class I evidence that for patients with neurogenic claudication, compared with diphenhydramine, pregabalin does not increase the time to moderate pain during a treadmill test. (Source: Neurology)
Source: Neurology - January 19, 2015 Category: Neurology Authors: Markman, J. D., Frazer, M. E., Rast, S. A., McDermott, M. P., Gewandter, J. S., Chowdhry, A. K., Czerniecka, K., Pilcher, W. H., Simon, L. S., Dworkin, R. H. Tags: All Clinical trials, Neuropathic pain, All Spinal Cord ARTICLE Source Type: research
Hypnotic use and multiple sclerosis related fatigue: a forgotten confounder
In the January issue of Sleep Medicine, Braley et al.  have published a cross-sectional study of 190 multiple sclerosis (MS) patients, showing that over-the-counter (OTC) hypnotic use, but not prescription hypnotic use, was independently associated with fatigue measured with the Fatigue Severity Scale (FSS)  after adjustment for insomnia (measured with the Insomnia Severity Index or ) and other clinical and sleep related confounds. Almost half (47%) of MS patients reported occasional or more frequent use of hypnotics, and the majority of them indicated the use of an OTC diphenhydramine-containing product. (Source: Sleep Medicine)
Source: Sleep Medicine - January 16, 2015 Category: Sleep Medicine Authors: Christian Veauthier Tags: Editorial Source Type: research
Hypnotic use and multiple sclerosis related fatigue: a forgotten confounder.
In this issue of Sleep Medicine, Braley et al.  have published a cross-sectional study of 190 multiple sclerosis (MS) patients, showing that over-the-counter (OTC) hypnotic use, but not prescription hypnotic use, was independently associated with fatigue measured with the Fatigue Severity Scale (FSS)  after adjustment for insomnia (measured with the Insomnia Severity Index (ISI) ) and other clinical and sleep related confounds. Almost half (47%) of MS patients reported occasional or more frequent use of hypnotics, and the majority of them indicated the use of an OTC diphenhydramine-containing product. (Source: Sleep Medicine)
Source: Sleep Medicine - January 16, 2015 Category: Sleep Medicine Authors: Christian Veauthier Tags: Editorial Source Type: research
Hypersensitivity to Laminaria: A Case Report and Review of Literature
We report a case of laminaria hypersensitivity treated with diphenhydramine and corticosteroids. A literature review identified 10 previously reported cases, with 8 recognized as anaphylaxis, and good outcomes with corticosteroids and antihistamines despite limited epinephrine utilization. Laminaria hypersensitivity is likely IgE mediated with an increased anaphylaxis risk with prior exposure. (Source: Contraception)
Source: Contraception - January 13, 2015 Category: OBGYN Authors: Tania Sierra, Melissa M. Figueroa, Katherine T. Chen, Britt Lunde, Adam Jacobs Tags: Original research article Source Type: research
Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California
Conclusions Antidepressants and stimulants were the most common drugs associated with ventricular dysrhythmias. Patients with suspected poisonings by medications with a high risk of ventricular dysrhythmia warrant prompt ECG monitoring. (Source: American Journal of Cardiovascular Drugs)
Source: American Journal of Cardiovascular Drugs - January 8, 2015 Category: Cardiology Source Type: research
Allergy to sunflower seed and sunflower butter as proposed vehicle for sensitization
Conclusions: A case of sunflower allergy in the context of household consumption of sunflower butter has not yet been reported. We suggest that homes which are intentionally peanut-safe may provide an environment whereby infants with impaired skin barrier are at increased risk of allergy to alternative ?butter? products being used, via cutaneous exposure to these products preceding oral introduction to the child. (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - January 8, 2015 Category: Allergy & Immunology Authors: Elana LavineMoshe Ben-Shoshan Source Type: research
Evaluation of Treatments for Pruritus in Epidermolysis Bullosa
The objective of the current study was to determine quantitatively which treatments individuals with EB have used for pruritus and to evaluate the perceived effectiveness of these treatments in pruritus relief. A questionnaire was developed to evaluate the treatments and therapies used for pruritus in patients of all ages and for all types of EB. Questions about bathing products, moisturizers, topical products, oral medications, dressings, and alternative therapies were included. A 5‐point Likert scale (−2 = relieves itch a lot, −1 = relieves itch a little, 0 = no change, 1 = increases itch a little, 2 = in...
Source: Pediatric Dermatology - December 29, 2014 Category: Dermatology Authors: Christina Danial, Rasidat Adeduntan, Emily S. Gorell, Anne W. Lucky, Amy S. Paller, Anna L. Bruckner, Elena Pope, Kimberly D. Morel, Moise L. Levy, Shufeng Li, Elaine S. Gilmore, Alfred T. Lane Tags: Original Article Source Type: research
Honey for acute cough in children.
CONCLUSIONS: Honey may be better than 'no treatment', diphenhydramine and placebo for the symptomatic relief of cough, but it is not better than dextromethorphan. None of the included studies assessed the effect of honey on 'cough duration' because intervention and follow-up were for one night only. There is no strong evidence for or against the use of honey. PMID: 25536086 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - December 23, 2014 Category: Journals (General) Authors: Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE Tags: Cochrane Database Syst Rev Source Type: research
Late-breaking abstract: Antitussive effect of a diphenhydramine-containing multicomponent cough syrup in acute viral cough
ConclusionOur results provide the initial evidence of the ability of diphenhydramine to inhibit cough reflex sensitivity in subjects with acute pathological cough. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Dicpinigaitis, P., Dhar, S., Johnson, A., Gayle, Y., Brew, J., Caparros-Wanderley, W. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research
Doxepin and diphenhydramine increased non-rapid eye movement sleep through blockade of histamine H1 receptors
Publication date: Available online 11 December 2014 Source:Pharmacology Biochemistry and Behavior Author(s): Yi-Qun Wang , Yohko Takata , Rui Li , Ze Zhang , Meng-qi Zhang , Yoshihiro Urade , Wei-Min Qu , Zhi-Li Huang Histaminergic neurons have been reported to play an important role in the regulation of sleep-wake behavior through the histamine H1 receptor (R, H1R). First generation H1R antagonists, such as doxepin and diphenhydramine, produce drowsiness in humans, and are occasionally used to treat insomnia. However, if H1R antagonists function via physically blocking the H1R remains unclear. In the current study, we u...
Source: Pharmacology Biochemistry and Behavior - December 11, 2014 Category: Biochemistry Source Type: research
Respiratory drugs prescribed off-label among children in the outpatient clinics of a hospital in Malaysia
Conclusion There was substantial prescribing of respiratory drugs for children in an off-label manner at the outpatient clinics at the Universiti Kebangsaan Malaysia Medical Centre. This highlights the need for more research to be carried out on respiratory drugs in the pediatric population. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 9, 2014 Category: Drugs & Pharmacology Source Type: research
In vitro detection of cardiotoxins or neurotoxins affecting ion channels or pumps using beating cardiomyocytes as alternative for animal testing.
Abstract The present study investigated if and to what extent murine stem cell-derived beating cardiomyocytes within embryoid bodies can be used as a broad screening in vitro assay for neurotoxicity testing, replacing for example in vivo tests for marine neurotoxins. Effect of nine model compounds, acting on either the Na(+), K(+), or Ca(2+) channels or the Na(+)/K(+) ATP-ase pump, on the beating was assessed. Diphenhydramine, veratridine, isradipine, verapamil and ouabain induced specific beating arrests that were reversible and none of the concentrations tested induced cytotoxicity. Three K(+) channel blockers, a...
Source: Toxicology in Vitro - December 2, 2014 Category: Toxicology Authors: Nicolas J, Hendriksen PJ, de Haan LH, Koning R, Rietjens IM, Bovee TF Tags: Toxicol In Vitro Source Type: research
An LC-MS/MS method for the simultaneous determination of lycorine and galanthamine in rat plasma and its application to pharmacokinetic study of Lycoris radiata extract in rats
Summary A rapid, sensitive, and selective liquid chromatography-tandem mass spectrometry was developed for the simultaneous determination of lycorine and galanthamine, two major constituents in Lycoris radiata extract, in rat plasma. Liquid-liquid extraction with ethyl ether was carried out using diphenhydramine as the internal standard. The two bioactive alkaloids were separated on a Zorbax SB-C18 reserved-phase column (150 mm × 4.6 mm, i.d., 5 μm) by gradient elution using a mobile phase consisting of methanol with 0.1% formic acid (A) and water with 0.1% formic acid (B) at a flow rate of 0.6 mL/min. All anal...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - December 1, 2014 Category: Research Source Type: research
Acute vocal fold dystonic reaction to Propofol: A case report
Publication date: Available online 20 November 2014 Source:American Journal of Otolaryngology Author(s): Rachel C. Steckelberg , David Tsiang , Kelly Pettijohn , Abie Mendelsohn , Nir Hoftman A 67-year old male underwent uneventful robotic-assisted thorascopic resection of a solitary pulmonary fibrous tumor. Immediately following extubation at the completion of the surgical procedure, the patient developed respiratory distress that did not resolve with treatment. Benadryl provided only temporary relief. Midazolam and Hydromorphone were given for anxiolysis and analgesia respectively, which provided transient relief of sy...
Source: American Journal of Otolaryngology - November 28, 2014 Category: Endocrinology Source Type: research
The Case Files: The Effects of an Epidural Steroid Injection
This study showed that the duration of absorption of 50 ml of air decreased from 5.8 to 1.9 weeks by 40% FiO2 from 1.9 to 0.6 weeks on room air and 100% FiO2, respectively. (Anesthesiology 1996;84:442.) Several diagnoses should be added to the headache differential diagnosis in the case of a patient receiving recent epidural spinal injections. Post-procedural headache or low-pressure headache, as well as pneumocephalus, should be added to the differential. The patient can be easily placed on a face mask to expedite air resorption, and can be provided symptom control as needed. This patient was successfully manag...
Source: The Case Files - November 21, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Stability of i.v. admixture containing metoclopramide, diphenhydramine hydrochloride, and dexamethasone sodium phosphate in 0.9% sodium chloride injection.
CONCLUSION: An i.v. admixture containing metoclopramide 1.6 mg/mL, diphenhydramine hydrochloride 2 mg/mL, and dexamethasone sodium phosphate 0.16 mg/mL in 0.9% sodium chloride injection was chemically stable for 48 hours when stored at room temperature without light protection. PMID: 25404598 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2014 Category: Drugs & Pharmacology Authors: Kintzel PE, Zhao T, Wen B, Sun D Tags: Am J Health Syst Pharm Source Type: research
Variability of bioavailability and intestinal absorption mechanisms of metoprolol.
Authors: Fukao M, Ishida K, Horie A, Taguchi M, Nozawa T, Inoue H, Hashimoto Y Abstract We previously reported that aging and/or cytochrome P450 2D6 polymorphism are responsible for the interindividual variability in the systemic clearance (CL) and bioavailability (F) of metoprolol. The aim of the present study was to evaluate the residual variability of F of metoprolol in routinely treated Japanese patients and to investigate the intestinal absorption mechanism of the drug using human intestinal epithelial LS180 cells. We first re-analyzed the blood concentration data for metoprolol in 34 Japanese patients using a...
Source: Drug Metabolism and Pharmacokinetics - November 18, 2014 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
Variability of bioavailability and intestinal absorption characteristics of bisoprolol.
Authors: Ishida K, Horie A, Nishimura M, Taguchi M, Fujii N, Nozawa T, Inoue H, Hashimoto Y Abstract We previously reported that renal function is partly responsible for the interindividual variability of the pharmacokinetics of bisoprolol. The aim of the present study was to examine the variability of bioavailability (F) of bisoprolol in routinely treated Japanese patients and intestinal absorption characteristics of the drug. We first analyzed the plasma concentration data of bisoprolol in 52 Japanese patients using a nonlinear mixed effects model. We also investigated the cellular uptake of bisoprolol using huma...
Source: Drug Metabolism and Pharmacokinetics - November 18, 2014 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
Modulatory effects of taurine on jejunal contractility.
Abstract Taurine (2-aminoethanesulfonic acid) is widely distributed in animal tissues and has diverse pharmacological effects. However, the role of taurine in modulating smooth muscle contractility is still controversial. We propose that taurine (5-80 mM) can exert bidirectional modulation on the contractility of isolated rat jejunal segments. Different low and high contractile states were induced in isolated jejunal segments of rats to observe the effects of taurine and the associated mechanisms. Taurine induced stimulatory effects on the contractility of isolated rat jejunal segments at 3 different low contractil...
Source: Braz J Med Biol Res - November 16, 2014 Category: Research Authors: Yao QY, Chen DP, Ye DM, Diao YP, Lin Y Tags: Braz J Med Biol Res Source Type: research
Efficacy and Tolerability of Benzodiazepines for the Treatment of Behavioral and Psychological Symptoms of Dementia: A Systematic Review of Randomized Controlled Trials
The objective of this review is to summarize the available data on the use of benzodiazepines for the treatment of behavioral and psychological symptoms of dementia (BPSD) from randomized controlled trials (RCTs). A systematic search of 5 major databases, PubMed, MEDLINE, PsychINFO, EMBASE, and Cochrane Collaboration, yielded a total of 5 RCTs. One study compared diazepam to thioridazine, 1 trial compared oxazepam to haloperidol and diphenhydramine, 1 trial compared alprazolam to lorazepam, 1 trial compared lorazepam to haloperidol, and 1 trial compared intramuscular (IM) lorazepam to IM olanzapine and placebo. The data in...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 12, 2014 Category: Geriatrics Authors: Tampi, R. R., Tampi, D. J. Tags: Reviews Source Type: research
Effects of antihistamines on the function of Human α7-nicotinic acetylcholine receptors.
Abstract Effects of the histamine H1 receptor (H1R) antagonists (antihistamines), promethazine (PMZ), orphenadrine (ORP), chlorpheniramine (CLP), pyrilamine (PYR), diphenhydramine (DPH), citerizine (CTZ), and triprolidine (TRP) on the functional properties of the cloned α7 subunit of the human nicotinic acetylcholine receptor expressed in Xenopus oocytes were investigated. Antihistamines inhibited the α7- nicotinic acetylcholine receptor in the order PYR>CLP>TRP>PMZ>ORP≥DPH≥CTZ. Among the antihistamines, PYR showed the highest reversible inhibition of acetylcholine (100µM)-induced responses with ...
Source: European Journal of Pharmacology - November 8, 2014 Category: Drugs & Pharmacology Authors: Sadek B, Soha Khanian S, Ashoor A, Prytkova T, Ghattas MA, Atatreh N, Nurulain SM, Susan Yang KH, Christopher Howarth F, Oz M Tags: Eur J Pharmacol Source Type: research
Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine
Publication date: 29 October 2014 Source:Life Sciences, Volume 116, Issue 2 Author(s): Mofei Wang , Toshishige Shibamoto , Mamoru Tanida , Yuhichi Kuda , Yasutaka Kurata Aims Systemic anaphylaxis is life-threatening, and its pathophysiology is not fully clarified. Mice are frequently used for experimental study on anaphylaxis. However, the hemodynamic features and mechanisms of mouse anaphylactic hypotension remain unknown. Therefore, we determined mechanisms of systemic and pulmonary vascular response to anaphylactic hypotension in anesthetized BALB/c mice by using receptor antagonists of chemical mediators. Main metho...
Source: Life Sciences - November 4, 2014 Category: Biology Source Type: research
Life-Threatening Diphenhydramine Toxicity Presenting With Seizures and a Wide Complex Tachycardia Improved With Intravenous Fat Emulsion
We present the case of a 30-year-old woman presenting with seizures, a wide complex tachycardia, and cardiovascular collapse after an ingestion of diphenhydramine refractory to other therapies with rapid improvement after IFE administration. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2014 Category: Drugs & Pharmacology Tags: Case Report Source Type: research
Fatal diphenhydramine poisoning in a dog.
We report a fatal diphenhydramine poisoning of a 10-year-old, male poodle-cross dog with pre-existing conditions and suspected co-ingestion of ethanol. This case illustrates that diphenhydramine overdose can be fatal in certain circumstances and that analytical toxicology may play an important role in animal death investigations. PMID: 25392554 [PubMed - in process] (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - November 1, 2014 Category: Veterinary Research Authors: Buchweitz JP, Raverty SA, Johnson MB, Lehner AF Tags: Can Vet J Source Type: research