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Sensitivity and specificity of intrathecal fluorescein and white light excitation for detecting intraoperative cerebrospinal fluid leak in endoscopic skull base surgery: a prospective study.
CONCLUSIONS ITF is extremely specific and very sensitive for detecting intraoperative CSF leaks. Although false negatives can occur, these patients do not appear to be at risk for postoperative CSF leak. The use of ITF may help surgeons prevent postoperative CSF leaks by intraoperatively detecting and confirming a watertight repair. PMID: 26295912 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - August 21, 2015 Category: Neurosurgery Authors: Raza SM, Banu MA, Donaldson A, Patel KS, Anand VK, Schwartz TH Tags: J Neurosurg Source Type: research

Open Channel Block of NMDA Receptors by Diphenhydramine.
CONCLUSION AND IMPLICATIONS: The data presented here provide evidence that the NMDA receptor antagonism of diphenhydramine contribute to its sedative and potentially LTP-related effects like analgesia and amnesia. PMID: 26284492 [PubMed - as supplied by publisher] (Source: Neuropharmacology)
Source: Neuropharmacology - August 15, 2015 Category: Drugs & Pharmacology Authors: Föhr KJ, Zeller K, Georgieff M, Köster S, Adolph O Tags: Neuropharmacology Source Type: research

Pharmacophore‐based discovery of inhibitors of a novel drug proton‐antiporter in human brain endothelial hCMEC/D3 cell line
Conclusions and implicationsThe pharmacophore model for the proton‐antiporter inhibitors was a good predictor of known inhibitors and allowed to identify new good inhibitors. This model marks a new step toward the discovery of this drug/proton‐antiporter and will be of great use for the discovery and design of stronger inhibitors that could potentially help to assess and validate its pharmacological role in drug addiction by inhibition strategy in vivo. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - July 29, 2015 Category: Drugs & Pharmacology Authors: Hélène Chapy, Laura Goracci, Philippe Vayer, Yannick Parmentier, Pierre‐Alain Carrupt, Xavier Declèves, Jean‐Michel Scherrmann, Salvatore Cisternino, Gabriele Cruciani Tags: RESEARCH PAPER Source Type: research

Clindamycin-induced hypersensitivity reaction
We report the case of a 46-year-old female who experienced anaphylaxis after a dose of intravenous (IV) clindamycin. Following treatment with methylprednisolone, epinephrine, diphenhydramine, and albuterol, the patient stabilized. The patient’s score on the Naranjo’s algorithm was 8 (probable); a score of 9 (definite) limited only by absence of drug re-challenge. To our knowledge, this is the first report of a clindamycin-induced anaphylaxis where the patient was not exposed to any other agent that may have triggered the response, the first case in the United States, and only the third documented case in the litera...
Source: Infection - July 28, 2015 Category: Infectious Diseases Source Type: research

Induction aND ANTAGONISM OF PICA INDUCED bY TERIPARATIDE IN RATS.
In this study, we investigated the characteristics of teriparatide-induced pica and the abilities of anti-emetic drugs to inhibit teriparatide-induced pica. Male and female adolescent (4-week-old), young (8-week-old), and adult (30-week-old) naive rats, and ovariectomized (OVX: 17-week-old) and sham-operated (17-week-old) rats subcutaneously received teriparatide (0.4mg/kg, n=4), and their kaolin and food intakes were monitored for 24h after the injection. Among the tested rats, we found that OVX rats, rather than male, female, and sham-operated rats, showed marked teriparatide-induced pica (0mg/kg: 0.17±0.07g, 0.4mg/kg: ...
Source: European Journal of Pharmacology - July 16, 2015 Category: Drugs & Pharmacology Authors: Yamamoto K, Kato N, Isogai Y, Kuroda T, Ishida T, Yamatodani A Tags: Eur J Pharmacol Source Type: research

A polyspecific drug/proton antiporter mediates diphenhydramine and clonidine transport at the mouse blood‐retinal barrier
Conclusions and implicationsA proton‐antiporter is physiologically involved in the transport of clonidine and diphenhydramine and is quantitatively more important than their passive diffusion flux at the mouse BRB. The features of this molecularly unidentified transporter highlight its importance in regulating drug delivery at the retina and suggest that it has the capacity to handle several drugs. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - July 14, 2015 Category: Drugs & Pharmacology Authors: Hélène Chapy, Pascal André, Xavier Declèves, Jean‐Michel Scherrmann, Salvatore Cisternino Tags: Research Paper Source Type: research

Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model
Conclusion In our study of diphenhydramine-induced hypotensive swine, we found no difference in hypotension, QRS widening, or diphenhydramine levels in aqueous layers between intravenous lipid emulsion and sodium bicarbonate. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - July 10, 2015 Category: Emergency Medicine Source Type: research

A Literature Review of the Use of Sodium Bicarbonate for the Treatment of QRS Widening.
This article will also address the literature supporting an increased serum sodium concentration, alkalemia, or the combination of both as the responsible mechanism(s) for sodium bicarbonate's antidotal properties. While sodium bicarbonate has been used as a treatment for cardiac sodium channel blockade for multiple other agents including citalopram, cocaine, flecainide, diphenhydramine, propoxyphene, and lamotrigine, it has uncertain efficacy with bupropion, propranolol, and taxine-containing plants. PMID: 26159649 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 10, 2015 Category: Toxicology Authors: Bruccoleri RE, Burns MM Tags: J Med Toxicol Source Type: research

Diphenhydramine and QT prolongation – A rare cardiac side effect of a drug used in common practice
We describe a case of a patient who developed QT prolongation with a temporal association with diphenhydramine usage.> (Source: Journal of Cardiology Cases)
Source: Journal of Cardiology Cases - July 4, 2015 Category: Cardiology Source Type: research

Interactions between histamine H1 receptor and its antagonists by using cell membrane chromatography method
ConclusionsThe studies showed CMC could be applied to investigate drug–receptor interactions. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 1, 2015 Category: Drugs & Pharmacology Authors: Weina Ma, Dongdong Zhang, Jing Li, Delu Che, Rui Liu, Jie Zhang, Yanmin Zhang Tags: Research Paper Source Type: research

Pulse‐Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs
Conclusions and clinical importanceCombined treatment with pulse‐administered TOC and lomustine generally is well tolerated and may be a reasonable treatment option for dogs with unresectable or metastatic MCT. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - June 25, 2015 Category: Veterinary Research Authors: J.H. Burton, R.O. Venable, D.M. Vail, L.E. Williams, C.A. Clifford, S.M. Axiak‐Bechtel, A.C. Avery, D.H. Thamm Tags: Standard Article Source Type: research

Stimulatory effects of histamine on migration of nasal fibroblasts
ConclusionWe showed that histamine stimulates fibroblast migration in nasal fibroblasts. This effect appeared to be mediated by HR1 and HR4. However, because fibroblast migration also can be involved in scaring and fibrosis, more research is necessary to determine the effects of antihistamine on wound healing after sinus surgery. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 10, 2015 Category: Allergy & Immunology Authors: Sung‐Moon Hong, Il‐Ho Park, Ji‐Young Um, Jae‐Min Shin, Heung‐Man Lee Tags: ORIGINAL ARTICLE Source Type: research

Identification of position isomers by energy‐resolved mass spectrometry
This study reports an energy‐resolved mass spectrometric (ERMS) strategy for the characterization of position isomers derived from the reaction of hydroxyl radicals (●OH) with diphenhydramine (DPH) that are usually hard to differentiate by other methods. The isomer analogues formed by ●OH attack on the side chain of DPH are identified with the help of a specific fragment ion peak (m/z 88) in the collision‐induced dissociation (CID) spectrum of the protonated molecule. In the negative ion mode, the breakdown curves of the deprotonated molecules show an order of stability (supported by density functional theory (DFT)...
Source: Journal of Mass Spectrometry - June 8, 2015 Category: Chemistry Authors: Sunil Paul M. Menachery, Olivier Laprévote, Thao P. Nguyen, Usha K. Aravind, Pramod Gopinathan, Charuvila T. Aravindakumar Tags: Research article Source Type: research

Pharmaceuticals in grocery market fish fillets by gas chromatography–mass spectrometry
Publication date: 1 January 2016 Source:Food Chemistry, Volume 190 Author(s): Musavvir Arafat Mottaleb , Carly Stowe , Daniel R. Johnson , Mohammed J. Meziani , M. Abdul Mottaleb Occurrences of pharmaceuticals are evident in aquatic organisms. A reproducible gas chromatography–mass spectrometry (GC–MS) method using selected ion monitoring (SIM) has been used to determine the anti-histamine diphenhydramine (DPH), anti-anxiety diazepam (DZP), anti-seizure carbamazepine (CZP) drugs and their metabolites in grocery stores fish that were homogenized, extracted, pre-concentrated, cleaned up, and examined. Identifications o...
Source: Food Chemistry - June 7, 2015 Category: Food Science Source Type: research

Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus.
This study further examined the components of the phase-separated layers using magnetic resonance (MR) spectroscopy and chemical shift selective images, and it was verified that the upper layer consisted of packed oil droplet layers, whereas the lower was an aqueous phase. Subsequently, the time-dependent phase separation of the sample at different temperatures was investigated. From the MR images, including a T2 relaxation time map and apparent diffusion coefficient maps, it was obvious that the phase separation developed further with increasing temperature; the most substantial phase separation was observed from the samp...
Source: Chemical and Pharmaceutical Bulletin - June 2, 2015 Category: Drugs & Pharmacology Authors: Onuki Y, Machida Y, Yokawa T, Seike C, Sakurai S, Takayama K Tags: Chem Pharm Bull (Tokyo) Source Type: research

A novel HPLC–MS/MS method for the simultaneous determination of astemizole and its major metabolite in dog or monkey plasma and application to pharmacokinetics
This report describes a novel high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method for simultaneously determining the concentrations of AST and DEA in beagle dog and cynomolgus monkey plasma with simple preparation method and short retention time. Prior to HPLC analyses, the plasma samples were extracted with simple liquid–liquid extraction method. The isocratic mobile phase was 0.025% trifluoroacetic acid (TFA dissolved in acetonitrile) and 20mM ammonium acetate (94:6) at a flow rate of 0.25mL/min and diphenhydramine used as internal standard. In MS/MS analyses, precursor ions of the a...
Source: Journal of Pharmaceutical and Biomedical Analysis - May 31, 2015 Category: Drugs & Pharmacology Source Type: research

A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs.
Abstract Dextromethorphan (DXM) and diphenhydramine (DPH) are two commonly used over-the-counter non-narcotic antitussive drugs. Recent reports reveal the widespread abuse of DXM and DPH due to their euphoric and alcohol-like effects. Due to their medicinal importance as well as the apparent increase in their use as abused drugs, it has become critical to determine them in samples of biological, clinical and pharmaceutical interest. The electrochemical techniques for drug analysis have gathered considerable attention due to their pronounced selectivity, sensitivity and simplicity. The given review presents a compil...
Source: Talanta - May 27, 2015 Category: Chemistry Authors: Thapliyal N, Patel H, Karpoormath R, Goyal RN, Patel R Tags: Talanta Source Type: research

The Case Files: Face and Neck Swelling Hint at a Daunting Diagnosis
By Mohammed Hassan-Ali, MSC & Ahmed Raziuddin, MD A 56-year-old black man presented to the ED complaining of face and neck swelling. An initial history was difficult to obtain because the patient did not speak English fluently and had slurred speech. Symptoms started approximately a week earlier when the patient was at his nursing home. He denied dysphagia or odynophagia, he had no rashes, pruritus, dyspnea, or peripheral edema, his face was flushed, and he had visibly-engorged neck veins. He noticed that his tongue was mildly swollen, so he took Benadryl for a week with no relief. The patient said he believed that th...
Source: The Case Files - May 26, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Chiral separation of (d)- and (l)-enantiomers of doxylamine succinate in rat plasma
Publication date: Available online 16 May 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Tadiboyina Sirisha , Bannimath Gurupadayya , Bharathkumar Inturi A selective chiral ultra fast liquid chromatography (UFLC-DAD) method was developed and validated to separate and quantify the (d)- and (l)-enantiomers of doxylamine in rat plasma. After extraction of the plasma samples with acetonitrile, the separation of doxylamine succinate enantiomers and internal standard (I.S., diphenhydramine hydrochloride) was achieved on a cellulose Tris (4-chloro,3-methylphenylcarbamate) column with a mobile phase of ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - May 17, 2015 Category: Drugs & Pharmacology Source Type: research

Evaluation of sol–gel TiO2 photocatalysts modified with carbon or boron compounds and crystallized in nitrogen or air atmospheres
Publication date: 1 October 2015 Source:Chemical Engineering Journal, Volume 277 Author(s): Alejandro Ansón-Casaos , Maria J. Sampaio , Clara Jarauta-Córdoba , M. Teresa Martínez , Cláudia G. Silva , Joaquim L. Faria , Adrián M.T. Silva Sol–gel TiO2 photocatalysts are synthesized from titanium isopropoxide and crystallized by thermal treatment under either air atmosphere or nitrogen flow. Reference TiO2 photocatalysts crystallized at 550°C for 30min in air are the most active for the degradation of diphenhydramine pharmaceutical (DPH). In addition, TiO2 precursors are modified with carbon or boron compounds. The ...
Source: Chemical Engineering Journal - May 15, 2015 Category: Chemistry Source Type: research

Direct injection of tissue extracts in liquid chromatography/tandem mass spectrometry for the determination of pharmaceuticals and other contaminants of emerging concern in mollusks.
Abstract In the present study, a straightforward approach was validated for the analysis of pharmaceutically active compounds and endocrine-disrupting chemicals in the mollusk tissues, with a focus on two species commonly consumed in Southeast Asia (green mussels: Perna viridis; lokan clams: Polymesoda expansa). This approach relied on a simple solvent extraction (shaker table) followed by direct injection in liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). This "cleanup-free" approach was made possible by the use of isotopically labeled surrogates (to correct for matrix effects) and a post-col...
Source: Analytical and Bioanalytical Chemistry - May 13, 2015 Category: Chemistry Authors: Bayen S, Estrada ES, Juhel G, Kelly BC Tags: Anal Bioanal Chem Source Type: research

Multidrug-related leukocytoclastic vasculitis raising suspicion of sexual homicide—things are not always what they seem
We report the case of a 35-year-old female deceased who had suffered from a borderline personality and depressive disorder with suicidal ideation. At the death scene, the body showed massive facial swelling accompanied by complete reddening of the skin of the face, with patchy skin abrasions on the forehead and neck, and purple bruise-like discolorations distributed symmetrically over both shoulders, elbows, hands, hips, knees, lower legs, and feet, raising the suspicion of underlying massive external blunt force injury. Police investigators strongly suspected sexual homicide. At autopsy, dissection in layers revealed mass...
Source: International Journal of Legal Medicine - May 10, 2015 Category: Medical Law Source Type: research

Localized Erythema Multiforme-Like Contact Dermatitis From a Knee Brace
Abstract: A 47-year-old woman developed allergic contact dermatitis (ACD) to a knee brace after anterior cruciate ligament repair, manifesting as numerous erythema multiforme-like lesions. No previous cases of ACD to this Townsend Rebel knee brace, which is commonly worn postoperatively, have been reported. The patient was treated with triamcinolone ointment, cetirizine, and diphenhydramine. On follow-up, the lesions had resolved. We share this case to increase knowledge of this reaction pattern and encourage further similar reports to clarify the nature of the reaction. (Source: Clinical Journal of Sport Medicine)
Source: Clinical Journal of Sport Medicine - May 1, 2015 Category: Sports Medicine Tags: Case Report Source Type: research

Sedation and Analgesia for Critically Ill Pediatric Burn Patients: The Current State of Practice
The objective of this study was to assess current practice patterns and attitudes toward pediatric sedation and analgesia in United States (US) burn centers for critically ill patients. Survey-based questionnaire was sent to 119 Directors at US burn centers that care for pediatric patients. Forty-one surveys (34%) were analyzed. 48.8% of responding centers mandate pediatric consultation for pediatric burn patients based on factors such as age and burn size. The most common sedation and analgesic agents used were midazolam, fentanyl, morphine, ketamine, and diphenhydramine. Written sedation policies exist at 63.4% of center...
Source: Journal of Burn Care and Research - May 1, 2015 Category: Rehabilitation Tags: Original Articles Source Type: research

Sex Differences In over-the-counter sleep aid use in older adults
Over-the-counter (OTC) sleep aids are widely self-administered and are generally safe, but their primary ingredients (diphenhydramine and doxylamine (DPH/DOX)) may pose risks, especially in older adults who may use these products outside of their label recommendations. This analysis characterizes the use of DPH/DOX for sleep disturbances by age and sex in older American adults. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: H.J. Gross, G. O’Neill, M. Toscani, J. Chapnick Source Type: research

Efficacy and tolerability studies evaluating a sleep aid and analgesic combination of naproxen sodium and diphenhydramine in the dental impaction pain model in subjects with induced transient insomnia
ConclusionsOnly the NS 440 mg/DPH 50 mg combination demonstrated improvement in both sleep latency vs. DPH 50 mg and sleep maintenance (WASO) vs. NS 440 mg. There were no serious or unexpected adverse events reported in either study. Clinical Trial Registration: NCT01280591 (study 1); NCT01495858 (study 2) (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - May 1, 2015 Category: Internal Medicine Authors: S. Cooper, I. Laurora, Y. Wang, P. Venkataraman, R. An, T. Roth Tags: Original Paper Source Type: research

Investigation of intercalation of diphenhydramine into the interlayer of smectite by XRD, FTIR, TG-DTG analyses and molecular simulation
In this study the intercalation of DPH in the interlayer of a Ca-smectite was characterized by X-ray diffraction, infra-red, and thermogravimetric analyses supported by molecular dynamic simulation. At the low (0.2–0.3 CEC) and high (0.6–0.7 CEC) adsorption levels, the intercalated DPH might take a horizontal monolayer or a bilayer configuration, resulting in a d001 expansion to 15 or 17 Å, respectively. As the amount of DPH intercalation increased, a gradual, yet systematic, dehydration due to removal of hydrated inorganic cation Ca2+ from the interlayer was observed. In addition, the intercalated DPH had a slightly ...
Source: Arabian Journal of Chemistry - April 25, 2015 Category: Chemistry Source Type: research

Intramolecular interactions contributing for the conformational preference of bioactive diphenhydramine: Manifestation of the gauche effect
Publication date: 5 August 2015 Source:Journal of Molecular Structure, Volume 1093 Author(s): Fátima M.P. de Rezende , Laize A.F. Andrade , Matheus P. Freitas Diphenhydramine is an antihistamine used to treat some symptoms of allergies and the common cold. It is usually marketed as the hydrochloride salt, and both the neutral and cation forms have the O–C–C–N fragment. The gauche effect is well known in fluorine-containing chains, because its main origin is hyperconjugative and the σ∗ C–F is a low-lying acceptor orbital, allowing electron delocalization in the conformation where F and an adjacent electronegat...
Source: Journal of Molecular Structure - April 22, 2015 Category: Molecular Biology Source Type: research

Enhanced Fenton-like degradation of pharmaceuticals over framework copper species in copper-doped mesoporous silica microspheres
Publication date: 15 August 2015 Source:Chemical Engineering Journal, Volume 274 Author(s): Lai Lyu , Lili Zhang , Chun Hu Copper-doped mesoporous silica microspheres (Cu-MSMs) with the coexistence of Cu(I) and Cu(II) were prepared using a hydrothermal process and characterized by several methods. The characterization studies suggested that 0.91wt% of the copper species could exist in the framework of the mesoporous silica microspheres by chemical binding of SiOCu; excess copper species were located in the extraframework sites, leading to more oxygen vacancies on the surface of the catalysts. The framework Cu of Cu-MSMs ...
Source: Chemical Engineering Journal - April 20, 2015 Category: Chemistry Source Type: research

Synthesis of pH-sensitive poly (N,N-dimethylaminoethyl methacrylate)-grafted halloysite nanotubes for adsorption and controlled release of DPH and DS drugs
Publication date: 18 May 2015 Source:Polymer, Volume 65 Author(s): Hamoon Hemmatpour , Vahid Haddadi-Asl , Hossein Roghani-Mamaqani Halloysite nanotube (HNT) was functionalized with (3-Aminopropyl)triethoxysilane (APTES), alpha-bromoisobutyryl bromide (BiBB), and poly (N,N-dimethylaminoethyl methacrylate) (PDMAEMA) chains. Successful grafting of PDMAEMA by SI-ATRP method was evaluated by XPS, FTIR, TEM, and TGA. Pore volume studies were accomplished by BET, and XRD was used to study crystalline structure of nanotubes. PDMAEMA coverage is formed on the outer and inner surface and also lumen of nanotubes. Sensitivity of PD...
Source: Polymer - April 17, 2015 Category: Chemistry Source Type: research

Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model.
Authors: Higuchi K, Kitamura A, Okura T, Deguchi Y Abstract Memantine is clinically used for the treatment of patients with Alzheimer's disease and is highly distributed to the brain. The aim of this study is to characterize memantine transport at the blood-brain barrier (BBB) using hCMEC/D3 cells, a human BBB model. The initial uptake velocity of memantine in hCMEC/D3 cells was concentration-dependent, and was reduced by metabolic inhibitors, but was independent of extracellular sodium ion and membrane potential. Intracellular alkalization and intracellular acidification markedly reduced and enhanced the uptake, r...
Source: Drug Metabolism and Pharmacokinetics - April 12, 2015 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

Effect of sodium chloride and myo-inositol on diphenhydramine hydrochloride drug in aqueous solution at different temperatures: Volumetric and acoustic approach
Publication date: August 2015 Source:The Journal of Chemical Thermodynamics, Volume 87 Author(s): Santosh P. Jengathe , Sudhakar S. Dhondge , Lalitmohan J. Paliwal , Vijay M. Tangde , Sudip Mondal Densities and speeds of sound of diphenhydramine hydrochloride (DPH) in aqueous solution and 0.06mol·kg−1 aqueous solutions of sodium chloride and myo-inositol (MI) have been measured at different temperatures, T =(288.15, 298.15 and 308.15)K over the concentration range (0.01 to 0.1)mol·kg−1. Density and speed of sound values were used to evaluate thermodynamic properties such as apparent molar volume (Vϕ ), isentropic ...
Source: The Journal of Chemical Thermodynamics - April 9, 2015 Category: Chemistry Source Type: research

Dosing, Side Effects, and Long-Term Outcomes for IVIg Use in Treatment of Neurological Conditions: Data from the Immunoglobulin Diagnosis, Evaluation, and key Learnings (IDEaL) Patient Registry (P6.036)
CONCLUSIONS: The data presented provides information on IVIg dosing for neurological subjects, and indicates that most patients did not report side effects from their IVIg therapy. The quality-of-life and outcomes data show improvements in overall physical function scores as well as in acute symptoms for patients receiving IVIg therapy. Study Supported by:Disclosure: Dr. Kearns has received personal compensation for activities with Coram Clinical Trials as an employee. Dr. Kristofek has received personal compensation for activities with Coram Clinical Trials as an employee. Dr. Bolgar has received personal compensation for...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kearns, S., Kristofek, L., Bolgar, B., Seidu, L. Tags: Neurotherapeutics Source Type: research

Occurrences of pharmaceuticals in drinking water sources of major river watersheds, China.
In this study, a survey for multi-class pharmaceuticals in DWSs of five major river watersheds in China was conducted from 2012 to 2013. Samples were collected from 25 sampling sites in rivers and reservoirs. 135 pharmaceuticals were analyzed using solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry. The results showed that a total of 70 pharmaceuticals were present in the samples, and the most frequently detected ones included sulfonamides, macrolides, antiepileptic drugs, anti-inflammatory drugs, and β-blockers, etc. Amongst these, maximum concentrations of lincomycin, sulfamethox...
Source: Ecotoxicology and Environmental Safety - April 3, 2015 Category: Environmental Health Authors: Sun J, Luo Q, Wang D, Wang Z Tags: Ecotoxicol Environ Saf Source Type: research

Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model.
Abstract In order to bridge the gap of action of dl-sotalol between the human ether-a-go-go-related gene (hERG) K(+) channel inhibition in vitro and QT-interval prolongation in vivo, its electropharmacological effect and pharmacokinetic property were simultaneously studied in comparison with those of 10 drugs having potential to prolong the QT interval (positive drugs: bepridil, haloperidol, dl-sotalol, terfenadine, thioridazine, moxifloxacin, pimozide, sparfloxacin, diphenhydramine, imipramine and ketoconazole) and four drugs lacking such property (negative drugs: enalapril, phenytoin, propranolol or verapamil) wi...
Source: Cardiovascular Toxicology - March 31, 2015 Category: Cardiology Authors: Katagi J, Nakamura Y, Cao X, Ohara H, Honda A, Izumi-Nakaseko H, Ando K, Sugiyama A Tags: Cardiovasc Toxicol Source Type: research

The Impact of Chronic Opioid Use on Colonoscopy Outcomes
Conclusion Patients on chronic opioids represent a high-risk population with longer procedural times and more discomfort, despite higher dosages of sedative agents. Prospective studies are required to define the risks and benefits of more costly alternative sedation strategies for patients on chronic opioids. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 31, 2015 Category: Gastroenterology Source Type: research

Concurrent quantification and comparative pharmacokinetic analysis of bioactive compounds in the Herba Ephedrae-Semen Armeniacae Amarum herb pair
Publication date: 10 May 2015 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 109 Author(s): Shuai Song , Feilong Chen , Xuefeng Xing , Mengyue Ren , Qinhai Ma , Ying Xie , Qingfa Tang , Jiabo Luo The Mahuang–Xingren herb-pair (MX), the combination of Herba Ephedrae (Mahuang in Chinese) and Semen Armeniacae Amarum (Xingren in Chinese), is a classical combination used in traditional Chinese Medicine to treat asthma and bronchitis. A simple and reliable ultra-performance liquid chromatography-tandem mass spectrometry method was developed to simultaneously quantify and compare the pharmacokinetics of 5 ep...
Source: Journal of Pharmaceutical and Biomedical Analysis - March 28, 2015 Category: Drugs & Pharmacology Source Type: research

Impact of Computerized Physician Order Entry Alerts on Prescribing in Older Patients
Conclusion The data suggest that prescribing rates for drugs with the least efficacy and potential for harm and with alternative agents (i.e., diphenhydramine and metoclopramide) can be modified by CPOE alerts for older patients. (Source: Drugs and Aging)
Source: Drugs and Aging - March 10, 2015 Category: Geriatrics Source Type: research

Adrenal renal fusion confusion: a case report of an adrenal cortical adenoma with adrenal–renal fusion
We report a case of laminaria hypersensitivity treated with diphenhydramine and corticosteroids. A literature review identified 10 previously reported cases, with 8 recognized as anaphylaxis, and good outcomes with corticosteroids and antihistamines despite limited epinephrine utilization. Laminaria hypersensitivity is likely IgE mediated with an increased anaphylaxis risk with prior exposure. (Source: Clinical Imaging)
Source: Clinical Imaging - March 7, 2015 Category: Radiology Authors: Shannon St. Clair, Stephen Machnicki, Alyssa Yurovitsky Tags: Case Report Source Type: research

An ultrasensitive electrochemiluminescence sensor for detecting diphenhydramine hydrochloride based on l-cysteine-functionalized multiwalled carbon nanotubes/gold nanoparticles nanocomposites
Publication date: 5 July 2015 Source:Sensors and Actuators B: Chemical, Volume 213 Author(s): Chongchong Miao , Amin Zhang , Yanan Xu , Shen Chen , Feimeng Ma , Chusen Huang , Nengqin Jia A new electrochemiluminescence (ECL) sensor was constructed for the ultrasensitive detection of diphenhydramine hydrochloride (DPH) based on l-cysteine-functionalized multiwalled carbon nanotubes/gold nanoparticles (MWCNTs-Cys-AuNPs) nanocomposites. In this work, the nanocomposites were facilely synthesized by using l-cysteine as linking agent which could covalently conjugate to MWCNTs and AuNPs via amide bond and AuS bond. Herein, the ...
Source: Sensors and Actuators B: Chemical - March 5, 2015 Category: Chemistry Source Type: research

Aspirin use associated with amyotrophic lateral sclerosis: a total population-based case-control study.
CONCLUSIONS: The results of this study suggested that aspirin use might reduce the risk of ALS, and the benefit might be more prominent for older people. PMID: 25721071 [PubMed - in process] (Source: Journal of Epidemiology)
Source: Journal of Epidemiology - March 2, 2015 Category: Epidemiology Tags: J Epidemiol Source Type: research

The Effect of Diphenhydramine on Sleep in Pediatric Burn Patients: A Secondary Analysis
Adequate sleep is essential for maintaining homeostasis, especially when recovering from an illness; however, studies have shown that sleep disruption and sleep deprivation are common in intensive care unit patients, including children who have sustained burn injury. The purpose of this study was to evaluate the effect of diphenhydramine (DPH) on sleep in pediatric intensive care unit burn patients using Myra Levine’s Conservation Model as the organizing framework. For this study, secondary analysis of polysomnography data and retrospective chart review were used. Twelve DPH patients were pair matched in terms of morphin...
Source: Journal of Burn Care and Research - February 28, 2015 Category: Rehabilitation Tags: Original Articles Source Type: research

Case Presentation: Trick or Treat?
The Monday morning staff meeting was beginning when a school-aged child and his mother walked up to the glass door. Although the clinic had not opened, upon seeing the child's startling appearance, the four nurse practitioners (NPs) sprang into action. His face was red and severely swollen, his lips were twice normal size, and his eyes were nearly swollen shut (Figure). One NP retrieved the oxygen tank, another reached for the EpiPen, and the third readied the diphenhydramine. The NP at the door talked to the child and assessed his breath sounds. (Source: Journal of Pediatric Health Care)
Source: Journal of Pediatric Health Care - February 21, 2015 Category: Pediatrics Authors: Nan Gaylord, Tami Bland Tags: Department Source Type: research

Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection
Conclusions: Our results provide the initial evidence of the ability of diphenhydramine to inhibit cough reflex sensitivity in subjects with acute pathological cough. Timing of cough reflex sensitivity measurement may not have allowed demonstration of maximal antitussive effect of dextromethorphan. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - February 12, 2015 Category: Drugs & Pharmacology Source Type: research

Ionic Fluids Containing Both Strongly and Weakly Interacting Ions of the Same Charge Have Unique Ionic and Chemical Environments as a Function of Ion Concentration.
Abstract Liquid multi-ion systems made by combining two or more salts can exhibit charge ordering and interactions not found in the parent salts, leading to new sets of properties. This is investigated herein by examining a liquid comprised of a single cation, 1-ethyl-3-methylimidazolium ([C2 mim](+) ), and two anions with different properties, acetate ([OAc](-) ) and bis(trifluoromethylsulfonyl)imide ([NTf2 ](-) ). NMR and IR spectroscopy indicate that the electrostatic interactions are quite different from those in either [C2 mim][OAc] or [C2 mim][NTf2 ]. This is attributed to the ability of [OAc](-) to form comp...
Source: Chemphyschem - February 4, 2015 Category: Chemistry Authors: Wang H, Kelley SP, Brantley JW, Chatel G, Shamshina J, Pereira JF, Debbeti V, Myerson AS, Rogers RD Tags: Chemphyschem Source Type: research

A Comparison of Acute Treatment Regimens for Migraine in the Emergency Department
CONCLUSIONS: The majority of children with migraines are successfully discharged from the ED and only 1 in 18 required a revisit within 3 days. Prochlorperazine appears to be superior to metoclopramide in preventing a revisit, and diphenhydramine use is associated with increased rates of return. (Source: PEDIATRICS)
Source: PEDIATRICS - February 2, 2015 Category: Pediatrics Authors: Bachur, R. G., Monuteaux, M. C., Neuman, M. I. Tags: Correction Article Source Type: research

A Comparison of Acute Treatment Regimens for Migraine in the Emergency Department
Migraine headaches are a common presenting complaint in emergency departments. Abortive treatment in this setting is not well studied, leading to considerable variation in treatment. The relationship between acute medications and emergency department revisits has not been studied. Eighty-five percent of children with migraine are successfully discharged from the emergency department; only 1 in 18 children require a return visit. Prochlorperazine is associated with less revisits than metoclopramide, and diphenhydramine use is associated with increased risk of return visits. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - February 2, 2015 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Deep Brain Stimulation In The Treatment OF Tardive Dyskinesia
We report a case a patient who suffered severe tardive dyskinesia which was resistant to change of medication, and the use of Cogentin, Benadryl or Botulinum toxin injections to alleviate her symptoms. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Puri, A. Albassam Source Type: research

Desensitization to ceftaroline in a patient with multiple medication hypersensitivity reactions.
CONCLUSION: Desensitization to ceftaroline was conducted for a patient with extensive history of hypersensitivity reactions to other drugs, including penicillin-induced anaphylaxis. Desensitization and subsequent treatment with full doses of ceftaroline were accomplished without apparent adverse effects. PMID: 25596602 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - January 27, 2015 Category: Drugs & Pharmacology Authors: Jones JM, Richter LM, Alonto A, Leedahl DD Tags: Am J Health Syst Pharm Source Type: research

Show Me the Evidence: Is the Routine Use of Premedication for Transfusion Really Necessary?
Improvements in transfusion medicine, blood typing, and donor screening have reduced the likelihood of a reaction from administration of blood products. In an effort to prevent transfusion reactions, our current standard is to administer acetaminophen 650mg and diphenhydramine 25mg, 30 minutes before transfusions. This practice may unnecessarily place patients at increased risk for complications including falls, cognitive impairment, and hepatic toxicity. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Julie Schutte, Ashlee Kwiatkowski, Jim Wischmeier, Sherry Amelung, Valerie Dougherty, Greg Voelkel, Eve Weber, Susan Hankins, Megan Colburn, Cheryl Wilson, Rebekah Flynn, Joyce Divanbeigi, Chris Rimkus Tags: Transplant Nursing Research Source Type: research