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Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.
Abstract Abstract 1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprotein bound) and ofloxacin (renally eliminated) were evaluated in cynomolgus monkeys (3-18 years old) and beagle dogs (2-11 years old) as models in elderly persons. 2. Gastric pH fluctuated with aging in monkeys and dogs. The concentration of alpha-1 acid glycoprotein appeared to be increased by aging. There were no age-related differences...
Source: Xenobiotica - March 21, 2014 Category: Research Authors: Koyanagi T, Yamaura Y, Yano K, Kim S, Yamazaki H Tags: Xenobiotica Source Type: research
Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval
We describe a retired nurse with history of depression, who began to develop drug‐seeking behaviour after her first receiving of an intramuscular (IM) DPH injection due to urticaria. Case summaryThe 49‐year‐old patient had developed IM DPH dependence within 4 months. She needed to receive psychiatric inpatient treatment because of depressive mood, serious myonecrosis over injected sites, and prolongation of QT interval. What is new and conclusionThis is the first reported case of DPH dependence through the IM route. Second‐generation antihistamines might be better choices for patients with psychiatric illness by re...
Source: Journal of Clinical Pharmacy and Therapeutics - March 6, 2014 Category: Drugs & Pharmacology Authors: T.‐Y. Chen, Y.‐W. Yeh, S.‐C. Kuo, C.‐Y. Chen, T.‐P. Lin, C.‐C. Chang Tags: Case Report Source Type: research
Mechanism of the Histamine H3 Receptor-mediated Increase in Exploratory Locomotor Activity and Anxiety-like Behaviours in Mice.
This study aimed to determine the mechanism underlying H3R-mediated behavioural changes using a specific H3R antagonist, JNJ-10181457 (JNJ). First, we examined the effect of JNJ injection to mice on the concentrations of brain monoamines and their metabolites. JNJ exclusively increased N(τ)-methylhistamine, the metabolite of brain histamine used as an indicator of histamine release, suggesting that JNJ dominantly stimulates the release of histamine release but not of other monoamines. Next, we examined the mechanism underlying JNJ-induced behavioural changes using open-field tests and elevated zero maze tests. JNJ-induced...
Source: Neuropharmacology - February 13, 2014 Category: Drugs & Pharmacology Authors: Mohsen A, Yoshikawa T, Miura Y, Nakamura T, Naganuma F, Shibuya K, Iida T, Harada R, Okamura N, Watanabe T, Yanai K Tags: Neuropharmacology Source Type: research
Effects of Diphenhydramine on aqueous tear production in dogs
Antihistamines competitively inhibit histamine at H1-receptors and reduce inflammatory reactions that result from allergic reactions. Use of topical antihistamine medications to treat ocular allergy has been seldom reported in veterinary medicine. Breeds commonly diagnosed with or at increased risk for developing atopic dermatitis and/or food allergy include the boxer, West Highland white terrier, English springer spaniel, miniature schnauzer, American cocker spaniel, shih tzu, Labrador retriever, and golden retriever. Antihistamines serve as a viable symptomatic treatment option for dogs unresponsive to therapy directed a...
Source: Advances in Small Animal Medicine and Surgery - February 1, 2014 Category: Veterinary Research Source Type: research
Parenteral Treatment of Episodic Tension‐Type Headache: A Systematic Review
ConclusionsVarious parenteral medications other than salicylates or nonsteroidals provide acute relief of tension‐type headache. Comparative efficacy studies are needed. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - January 16, 2014 Category: Neurology Authors: Danielle Weinman, Olivia Nicastro, Olabiyi Akala, Benjamin W. Friedman Tags: Review Article Source Type: research
Parenteral Treatment of Episodic Tension-Type Headache: A Systematic Review.
CONCLUSIONS: Various parenteral medications other than salicylates or nonsteroidals provide acute relief of tension-type headache. Comparative efficacy studies are needed. PMID: 24433525 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - January 16, 2014 Category: Neurology Authors: Weinman D, Nicastro O, Akala O, Friedman BW Tags: Headache Source Type: research
An Approach to Heparin and Lidocaine Hypersensitivity for the Interventional Nephrologist.
Abstract The general and interventional nephrologist may occasionally encounter a situation where the patient may state that he/she has an allergy to lidocaine or heparin. Heparin hypersensitivity is usually either a delayed type hypersensitivity reaction or an immune-mediated thrombocytopenia. While a number of alternative drugs are available, many of them are subject to local availability, food and drug administration indications, and the patient's hepatic and renal function. Many of these drugs do not have antidotes in case of bleeding. Lidocaine hypersensitivity is usually a delayed type reaction, although adve...
Source: Seminars in Dialysis - January 8, 2014 Category: Urology & Nephrology Authors: Sequeira A Tags: Semin Dial Source Type: research
An Approach to Heparin and Lidocaine Hypersensitivity for the Interventional Nephrologist
Abstract The general and interventional nephrologist may occasionally encounter a situation where the patient may state that he/she has an allergy to lidocaine or heparin. Heparin hypersensitivity is usually either a delayed type hypersensitivity reaction or an immune‐mediated thrombocytopenia. While a number of alternative drugs are available, many of them are subject to local availability, food and drug administration indications, and the patient's hepatic and renal function. Many of these drugs do not have antidotes in case of bleeding. Lidocaine hypersensitivity is usually a delayed type reaction, although adverse re...
Source: Seminars In Dialysis - January 8, 2014 Category: Hematology Authors: Adrian Sequeira Tags: Original Article Source Type: research
Presumptive immune‐mediated thrombocytopenia secondary to massive Africanized bee envenomation in a dog
Abstract ObjectiveTo describe a case of immune‐mediated thrombocytopenia (IMT) after massive Africanized bee envenomation in a dog. Case SummaryWhile boarding at a kennel, a dog was stung by approximately 300 Africanized bees. During initial veterinary examination, the dog was deemed to be in shock, characterized by collapse, with hypotension, bradycardia, and hypoglycemia. In addition, severe diffuse erythema and edema were noted over the entire body. Supportive care, including IV crystalloid and colloid fluids, dextrose, fresh frozen plasma, oxygen therapy, broad spectrum antimicrobials, dexamethasone, and diphenhydram...
Source: Journal of Veterinary Emergency and Critical Care - December 4, 2013 Category: Veterinary Research Authors: Reid K. Nakamura, Renee K. Fenty, Domenico Bianco Tags: Case Report Source Type: research
Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor.
CONCLUSION: PAF stimulates human mast cell release of proinflammatory mediators that is inhibited by RUP. This action endows RUP with additional properties in treating allergic inflammation. PMID: 24267366 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 29, 2013 Category: Allergy & Immunology Authors: Alevizos M, Karagkouni A, Vasiadi M, Sismanopoulos N, Makris M, Kalogeromitros D, Theoharides TC Tags: Ann Allergy Asthma Immunol Source Type: research
Proton-coupled organic cation antiporter-mediated uptake of apomorphine enantiomers in human brain capillary endothelial cell line hCMEC/D3.
Abstract R(-)-Apomorphine is a dopamine agonist used for rescue management of motor function impairment associated with levodopa therapy in Parkinson's disease patients. The aim of this study was to examine the role of proton-coupled organic cation antiporter in uptake of R(-)-apomorphine and its S-enantiomer in human brain, using human endothelial cell line hCMEC/D3 as a model. Uptake of R(-)- or S(+)-apomorphine into hCMEC/D3 cells was measured under various conditions to evaluate its time-, concentration-, energy- and ion-dependency. Inhibition by selected organic cations was also examined. Uptakes of both R(-)-...
Source: Biological and Pharmaceutical Bulletin - November 20, 2013 Category: Drugs & Pharmacology Authors: Okura T, Higuchi K, Kitamura A, Deguchi Y Tags: Biol Pharm Bull Source Type: research
Post-mortem evidence of doxylamine in toxicological analyses
Conclusion: Benchmarks published in past literature are meant as orientation during evaluation of post-mortem DA evidence. These should not be used as absolute values and need to be interpreted individually in each case. Post-mortem redistribution needs to be considered as a main factor in alteration of DA concentration measurement. Furthermore, proof of DA ingestion found in gastric content should only be interpreted quantitatively due to unreliable calculation of the ingested amount. In conclusion, a variety of factors, such as the time period between time of death and the time of the first toxicological analysis, the co...
Source: Science and Justice - November 18, 2013 Category: Forensic Medicine Authors: Lena Eckes, Michael Tsokos, Sieglinde Herre, René Gapert, Sven Hartwig Tags: Scientific and Technical Articles Source Type: research
Bitter Taste Receptor Function in Asthmatic and Nonasthmatic Human Airway Smooth Muscle Cells.
Abstract Bitter taste receptors (TAS2Rs) have recently been found to be expressed on human airway smooth muscle (HASM) and their activation results in marked relaxation. These agents have been proposed as a new class of bronchodilators in the treatment of obstructive lung diseases since they act via a different mechanism than -agonists. The TAS2R signal transduction pathway in HASM has multiple elements that are potentially subject to regulation by inflammatory, genetic, and epigenetic mechanisms associated with asthma. To address this, expression, signaling and physiologic functions of the three major TAS2Rs (s...
Source: American Journal of Respiratory Cell and Molecular Biology - November 12, 2013 Category: Molecular Biology Authors: Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri Jr RA, Liggett SB Tags: Am J Respir Cell Mol Biol Source Type: research
Mechanism-Driven Phase I Translational Study of Trifluoperazine in Adults with Sickle Cell Disease.
Abstract Recent evidence of neuropathic pain among adults with sickle cell disease (SCD) reveals a need for adjuvant analgesic treatments for these patients. Ca(2+)/calmodulin protein kinase IIα (CaMKIIα) has a known role in neuropathic pain and trifluoperazine is a potent CaMKIIα inhibitor. The study aim was to determine trifluoperazine's acute effects, primarily on adverse effects and secondarily on pain intensity reduction, in adults with SCD. In a phase I, open-label study of 6 doses of trifluoperazine (0.5, 1, 2, 5, 7.5, 10mg), we obtained 7-hourly and 24-hour repeated measures of adverse effects, pain inte...
Source: European Journal of Pharmacology - November 7, 2013 Category: Drugs & Pharmacology Authors: Molokie RE, Wilkie DJ, Wittert H, Suarez ML, Yao Y, Zhao Z, He Y, Wang ZJ Tags: Eur J Pharmacol Source Type: research
Acute pain transfusion reaction.
Abstract A 34-year-old woman with a diagnosis of hemophagocytic lymphohistocytosis (HLH) received a double umbilical cord blood transplantation following a myeloablative chemotherapy preparative regimen with busulfan and cyclophosphamide. HLH is a rare, potentially fatal hematologic disorder characterized by the overactivation of histocytes and T lymphocytes, leading to organ infiltration and acute illness. On day 25 post-transplantation, the patient required a platelet transfusion for a platelet count of 6,000 per ml (normal range = 150,000-450,000 per ml). The patient's blood type prior to the cord blood transpla...
Source: Oncology Nursing Forum - November 1, 2013 Category: Nursing Authors: Hardwick J, Osswald M, Walker D Tags: Oncol Nurs Forum Source Type: research
Pharmacokinetic variability of flecainide in younger Japanese patients and mechanisms for renal excretion and intestinal absorption
This article is protected by copyright. All rights reserved. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - October 28, 2013 Category: Drugs & Pharmacology Authors: Asuka Horie, Kazuya Ishida, Kaito Shibata, Masato Taguchi, Ayaka Ozawa, Keiichi Hirono, Fukiko Ichida, Yukiya Hashimoto Tags: Original Paper Source Type: research
Simultaneous determination of three major lignans in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Diphylleia sinensis extract.
Abstract A sensitive and selective liquid chromatography tandem mass spectrometry was developed and validated for the simultaneous determination of three major lignans (podophyllotoxin, epipodophyllotoxin, and 4'-demethylpodophyllotoxin) in rat plasma using diphenhydramine as the internal standard. The analytes were detected using a triple quadrupole mass spectrometer that was equipped with an electrospray ionization source in the positive ion and selected reaction monitoring modes. The linearity of the calibration curve was good, with coefficients of determination (r(2) ) >0.9914 for all of the analytes. The de...
Source: Biomedical Chromatography : BMC - October 14, 2013 Category: Biomedical Science Authors: Zhao C, Zhang N, He W, Li R, Shi D, Pang L, Dong N, Xu H, Ji H Tags: Biomed Chromatogr Source Type: research
Anaphylactic shock associated with intravenous thrombolytics
We report a case report of anaphylactic reaction directly attributable to intravenous (IV) recombinant tissue plasminogen activator and identify additional cases through review of the Food and Drug Administration Adverse Event Reporting System. A systematic review of Adverse Event Reporting System was performed for allergic adverse events occurring in conjunction with IV thrombolytics. We reviewed 924 adverse events which occurred between 2004 and 2012 that were associated with thrombolytics. We subsequently acquired detailed individual safety reports of 33 cases in which allergic events were documented. Out of the 33 repo...
Source: The American Journal of Emergency Medicine - October 2, 2013 Category: Emergency Medicine Authors: Amna Zarar, Asif A. Khan, Malik M. Adil, Adnan I. Qureshi Tags: Case Reports Source Type: research
Acute generalized exanthematous pustulosis in a patient receiving high-dose recombinant interleukin-2
To the Editor: A 65-year-old man with metastatic renal cell carcinoma was hospitalized for cycle 2 of standard high-dose recombinant interleukin-2 (IL-2) therapy at a dose of 720,000 units per kg administered every 8 hours. The patient had received 12 doses of IL-2 during the first cycle, which was completed 1 week earlier. After the administration of 6 doses of IL-2 in the second cycle, the patient developed erythroderma. Within the erythrodermic areas were numerous nonfollicular pustules, most prominently on the trunk and extremities (). There were no mucous membrane lesions, nail changes, or joint pains. The eruption wa...
Source: Journal of the American Academy of Dermatology - September 20, 2013 Category: Dermatology Authors: Nilanthi D. Gunawardane, Sapna P. Vaghani, Timothy M. Kuzel, Jonathan A. Cotliar Tags: JAAD Online Source Type: research
Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: A randomized clinical trial
Abstract: Mental health is an important medical issue in perinatal care, and there is increasing evidence that insomnia during pregnancy is associated with postpartum depression (PPD). Therefore, the present study evaluated the effect of insomnia treatment during the third trimester of pregnancy on PPD symptoms. Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment. Sleep quality was measured by actigraphy at baseline, and after 2 and 6 weeks of treatment. In addition, depression was assessed 2 and 6 weeks after delivery. Trazodone and diphenhydramine improved sl...
Source: Psychiatry Research - September 3, 2013 Category: Psychiatry Authors: Habibolah Khazaie, Mohammad Rasoul Ghadami, David C. Knight, Farnoosh Emamian, Masoud Tahmasian Tags: Depression and depressive disorder Source Type: research
Topiramate for neuropathic pain and fibromyalgia in adults.
CONCLUSIONS: Topiramate is without evidence of efficacy in diabetic neuropathic pain, the only neuropathic condition in which it has been adequately tested. The data we have includes the likelihood of major bias due to LOCF imputation, where adverse event withdrawals are much higher with active treatment than placebo control. Despite the strong potential for bias, no difference in efficacy between topiramate and placebo was apparent. PMID: 23996081 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - August 30, 2013 Category: Journals (General) Authors: Wiffen PJ, Derry S, Lunn MP, Moore RA Tags: Cochrane Database Syst Rev Source Type: research
Diphenhydramine produces local cutaneous analgesia in response to dorsal skin noxious stimuli in the rat
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - August 16, 2013 Category: Drugs & Pharmacology Authors: Yu‐Wen Chen, Jann‐Inn Tzeng, Ting‐Yun Chen, Jhi‐Joung Wang, Yu‐Chung Chen, Ching‐Hsia Hung Tags: Original Article Source Type: research
Caution with interpreting laboratory results after lipid rescue therapy
Intravenous lipid rescue therapy (LRT) may be implemented to attenuate drug toxicity. Little is known about LRT interference with laboratory tests in overdose settings. A 54-year-old man with a history of depression consumed unknown amounts of diphenhydramine, amitriptyline, and acetaminophen (APAP). Initial workup showed aspartate aminotransferase (AST) of 138 U/L, APAP of 177 μg/mL, and a QRS interval of 136 milliseconds. N-acetylcysteine, sodium bicarbonate, and 20% intravenous LRT were initiated. Laboratory test results drawn less than 6 hours later showed an APAP level of 44 μg/mL and an undetectable AST (Siemens Vi...
Source: The American Journal of Emergency Medicine - August 12, 2013 Category: Emergency Medicine Authors: Mohan Punja, Stewart G. Neill, Stella Wong, Tags: Case Reports Source Type: research
Exuberant connubial allergic contact dermatitis from diphenhydramine.
We report a case of a connubial dermatitis caused by topical diphenhydramine in a woman who applied the cream on her husband's back. PMID: 23848819 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 12, 2013 Category: Toxicology Authors: Teixeira V, Cabral R, Gonçalo M Tags: Cutan Ocul Toxicol Source Type: research
Interaction of active compounds from Aegle marmelos CORREA with histamine-1 receptor.
CONCLUSIONS: Based on molecular docking, Amino acid residues involved in ligand protein interactions were Asp107, Lys179, Lys191, Asn198, and Trp428. PMID: 23750086 [PubMed] (Source: Bioinformation)
Source: Bioinformation - June 15, 2013 Category: Bioinformatics Authors: Nugroho AE, Agistia DD, Tegar M, Purnomo H Tags: Bioinformation Source Type: research
Antihistamines and other prognostic factors for adverse outcome in hyperemesis gravidarum.
CONCLUSION: Poor outcomes are significantly greater in women with HG and are associated with gestational hypertension, early symptoms, and antihistamine use. Given these results, there is an urgent need to address the safety and effectiveness of medications containing antihistamines in women with severe nausea of pregnancy. PMID: 23751910 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - June 7, 2013 Category: Reproduction Medicine Authors: Fejzo MS, Magtira A, Schoenberg FP, Macgibbon K, Mullin P, Romero R, Tabsh K Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research
Use of QT‐prolonging medications in US emergency departments, 1995–2009
ConclusionUse of QT‐prolonging medications is increasing in EDs nationally. A small number of agents account for a large proportion of these visits and may represent an area for targeted screening or monitoring interventions in the ED. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - May 21, 2013 Category: Drugs & Pharmacology Authors: Khoon‐Yen Tay, Michele Burns Ewald, Florence T. Bourgeois Tags: Original Report Source Type: research
The role of hepatic transport and metabolism in the interactions between pravastatin or repaglinide and two rOatp inhibitors in rats.
Abstract A change in the function or expression of hepatic drug transporters may have significant effect on the efficacy or safety of orally administered drugs. Although a number of clinical drug-drug interactions associated with hepatic transport proteins have been reported, in practice it is not always straightforward to discriminate other pathways (e.g. drug metabolism) from being involved in these interactions. The present study was designed to assess the interactions between organic anion transporting polypeptide (Oatp) substrates (pravastatin or repaglinide) and inhibitors (spironolactone or diphenhydramine) ...
Source: European Journal of Pharmaceutical Sciences - May 3, 2013 Category: Drugs & Pharmacology Authors: Badolo L, Bundgaard C, Garmer M, Jensen B Tags: Eur J Pharm Sci Source Type: research
Association Between Sedating Medications and Delirium in Older Inpatients
ConclusionAn association was found between several Beers criteria sedative medications and delirium in hospitalized medical patients. Given the prevalence of these medications and the morbidity associated with delirium, further investigation into the appropriateness of such prescribing is warranted. (Source: Journal of the American Geriatrics Society)
Source: Journal of the American Geriatrics Society - April 30, 2013 Category: Geriatrics Authors: Michael B. Rothberg, Shoshana J. Herzig, Penelope S. Pekow, Jill Avrunin, Tara Lagu, Peter K. Lindenauer Tags: Clinical Investigations Source Type: research
A Randomized Trial of Intravenous Ketorolac Versus Intravenous Metoclopramide Plus Diphenhydramine for Tension-Type and All Nonmigraine, Noncluster Recurrent Headaches
Conclusion: For adults who presented to an ED with tension-type headache or with nonmigraine, noncluster recurrent headache, intravenous metoclopramide+diphenhydramine provided more headache relief than intravenous ketorolac. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - April 8, 2013 Category: Emergency Medicine Authors: Benjamin W. Friedman, Victoria Adewunmi, Caron Campbell, Clemencia Solorzano, David Esses, Polly E. Bijur, E. John Gallagher Tags: Pain Management and Sedation Source Type: research
Histamine synergistically promotes bFGF‐induced angiogenesis by enhancing VEGF production via H1 receptor
Abstract Histamine, a major mediator present in mast cells that is released into the extracellular milieu upon degranulation, is well known to possess a wide range of biological activities in several classic physiological and pathological processes. However, whether and how it participates in angiogenesis remains obscure. In the present study, we observed its direct and synergistic action with basic fibroblast growth factor (bFGF), an important inducer of angiogenesis, on in vitro angiogenesis models of endothelial cells. Data showed that histamine (0.1, 1, 10 µM) itself was absent of direct effects on the processes of ...
Source: Journal of Cellular Biochemistry - March 14, 2013 Category: Biochemistry Authors: Qian Lu, Chong Wang, Rong Pan, Xinghua Gao, Zhifeng Wei, Yufeng Xia, Yue Dai Tags: Article Source Type: research
A Novel Topical Formulation Containing Strontium Chloride Significantly Reduces the Intensity and Duration of Cowhage-Induced Itch.
Abstract The aim of this double-blinded, vehicle-controlled study was to test the antipruritic efficacy of topical strontium to relieve a nonhistaminergic form of itch that would be clinically relevant for chronic pruritic diseases. Itch induced with cowhage is mediated by PAR2 receptors which are considered to play a major role in itch of atopic dermatitis and possibly other acute and chronic pruritic conditions. The topical strontium hydrogel formulation (TriCalm®) was tested in a head-to-head comparison with 2 common topical formulations marketed as antipruritics: hydrocortisone and diphenhydramine, for their a...
Source: Acta Dermato-Venereologica - March 8, 2013 Category: Dermatology Authors: Papoiu AD, Valdes-Rodriguez R, Nattkemper LA, Chan YH, Hahn GS, Yosipovitch G Tags: Acta Derm Venereol Source Type: research
Aprepitant/dexamethasone/diphenhydramine/palonosetron: Grade 3 anaphylaxis: case report
Source: Reactions - February 15, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research
Effectiveness of Standardized Combination Therapy for Migraine Treatment in the Pediatric Emergency Department.
CONCLUSION: Standardized combination therapy is effective for acute pediatric migraine therapy in the ED by significantly reducing headache pain scores, length of ED stay, and hospital admission rates. PMID: 23406529 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - February 13, 2013 Category: Neurology Authors: Leung S, Bulloch B, Young C, Yonker M, Hostetler M Tags: Headache Source Type: research
Effectiveness of Standardized Combination Therapy for Migraine Treatment in the Pediatric Emergency Department
ConclusionStandardized combination therapy is effective for acute pediatric migraine therapy in the ED by significantly reducing headache pain scores, length of ED stay, and hospital admission rates. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - February 13, 2013 Category: Neurology Authors: Stephanie Leung, Blake Bulloch, Christine Young, Marcy Yonker, Mark Hostetler Tags: Research Submission Source Type: research
Delayed urticaria to beef ingestion
To the Editor: A 50-year-old man presented with a 5-year history of urticaria developing approximately 3 hours after eating ground beef. The eruption cleared with diphenhydramine. In the next 4 years, the patient experienced similar eruptions every time he ate ground beef. Recently, he had awoken with urticaria about 4 hours after consuming a large steak. He reported no problems with chicken, other fowl, or fish ingestion. IgE level to galactose-alpha-1,3-galactose (alpha-gal) was 47 kU/L (normal (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 11, 2013 Category: Dermatology Authors: Henry Benjamin Coker, Margaret Earley Jakes, Elizabeth Ann Mountcastle Tags: JAAD Online Source Type: research
Functional expression of a proton-coupled organic cation (H + /OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood¿brain barrier model
Conclusions: The present results suggest that H+/OC antiporter is functionally expressed in hCMEC/D3 cells. (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 26, 2013 Category: Neurology Authors: Keita ShimomuraTakashi OkuraSayaka KatoPierre-Olivier CouraudJean-Michel SchermannTetsuya TerasakiYoshiharu Deguchi Source Type: research
Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood--brain barrier model
Conclusions: The present results suggest that H+/OC antiporter is functionally expressed in hCMEC/D3 cells. (Source: BioMed Central)
Source: BioMed Central - January 26, 2013 Category: Journals (General) Authors: Keita ShimomuraTakashi OkuraSayaka KatoPierre-Olivier CouraudJean-Michel SchermannTetsuya TerasakiYoshiharu Deguchi Source Type: research
Drug-induced movement disorders in children at paediatric emergency department: 'dystonia'
Conclusion Dystonia is a common side effect of certain drugs, even when therapeutic doses are administered. Although the most common DIDRs were abnormal postures of the head and neck, rare life-threatening conditions, may develop particularly due to use of antipsychotics. In treatment, diphenhydramine could effectively be used through parenteral way to eliminate the cholinergic effects of those drugs. However, the easiest and the safest way to prevent the development of DRs is to avoid unnecessary drug usage. In conclusion, physicians should be aware that antiemetic and antipsychotic drugs are associated with DRs in normal...
Source: Emergency Medicine Journal - January 24, 2013 Category: Emergency Medicine Authors: Derinoz, O., Caglar, A. A. Tags: Child and adolescent psychiatry (paedatrics), Psychotic disorders (incl schizophrenia), Ear, nose and throat/otolaryngology Original articles Source Type: research
Cerebral Vasoconstriction Triggered By Sympathomimetic Drugs During Intra-atrerial Chemotherapy
In this report, we highlight the potential risk of reversible cerebral vasoconstriction in children administered vasoactive drugs and discuss its relevance during treatment of retinoblastoma by intraarterial chemotherapy. (Source: Pediatric Neurology)
Source: Pediatric Neurology - January 21, 2013 Category: Neurology Authors: Todd Abruzzo, Mario Patino, James Leach, Ralph Rahme, James Geller Tags: Case Reports Source Type: research
A Cutaneous Marker of Hepatitis C Virus
Question: A 53-year-old woman with hepatitis C (HCV) cirrhosis was admitted to our inpatient service with several days of progressive bilateral lower extremity pruritus, accompanied by severe pain and parasthesias. She had experienced intermittent pruritus for 2 years, but symptoms had become more severe in the 4 days before admission. Her pain was stabbing in nature and without radiation. Her pruritus has been refractory to multiple therapies including hydroxyzine, diphenhydramine, sertraline, cholestyramine, rifampin, naltrexone, topical steroids, and narrow band ultraviolet-B light therapy. She was hospitalized in March...
Source: Gastroenterology - December 17, 2012 Category: Gastroenterology Authors: Mazen Albeldawi, Vivian Ebrahim, Dian Jung Chiang Tags: Clinical Challenges and Images in GI Source Type: research
Histamine synergistically promotes bFGF‐induced angiogenesis by enhancing VEGF production via H1 receptor and activation of eNOS, p‐38 MAP kinase and NF‐κB pathways
Abstract Histamine, a major mediator present in mast cells that is released into the extracellular milieu upon degranulation, is well known to possess a wide range of biological activities in several classic physiological and pathological processes. However, whether and how it participates in angiogenesis remains obscure. In the present study, we observed its direct and synergistic action with basic fibroblast growth factor (bFGF), an important inducer of angiogenesis, on in vitro angiogenesis models of endothelial cells. Data showed that histamine (0.1, 1, 10 µM) itself was absent of direct effects on the processes of an...
Source: Journal of Cellular Biochemistry - December 5, 2012 Category: Biochemistry Authors: Qian Lu, Chong Wang, Rong Pan, Xinghua Gao, Zhifeng Wei, Yufeng Xia, Yue Dai Tags: Article Source Type: research
Effects of oral administration of diphenhydramine on pupil diameter, intraocular pressure, tear production, tear film quality, conjunctival goblet cell density, and corneal sensitivity of clinically normal adult dogs.
CONCLUSIONS AND CLINICAL RELEVANCE: Results of this study suggested that oral administration of diphenhydramine to healthy adult dogs was not likely to acutely induce glaucoma or keratoconjunctivitis sicca. However, effects of diphenhydramine in dogs with keratoconjunctivitis sicca or primary glaucoma or dogs genetically predisposed to development of those conditions were not determined. Administration of diphenhydramine to dogs decreased corneal sensitivity and tear film breakup time, although these effects were not clinically important. PMID: 23176427 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - December 1, 2012 Category: Veterinary Research Authors: Evans PM, Lynch GL, Labelle P Tags: Am J Vet Res Source Type: research
Carnosine protects brain microvascular endothelial cells against rotenone-induced oxidative stress injury through histamine H(1) and H(2) receptors in vitro.
In this study, we investigated this possibility by using an in vitro rotenone-induced oxidative stress model. Apoptosis of microvascular cells was analyzed by Hoechst 33342 staining and mitochondrial membrane potential was assessed by JC-1 staining. The intracellular carnosine and histamine levels were determined with high performance or ultra-high-pressure liquid chromatography analyses. We found that carnosine decreased the number of apoptotic cells at 18 h after rotenone exposure in a dose dependent manner, which was reversed either by histamine H(1) antagonists pyrilamine and diphenhydramine, or H(2) antagonists cimeti...
Source: Clinical and Experimental Pharmacology and Physiology - November 5, 2012 Category: Drugs & Pharmacology Authors: Zhang L, Yao K, Fan Y, He P, Wang X, Hu WW, Chen Z Tags: Clin Exp Pharmacol Physiol Source Type: research
Seizure activity during cetuximab infusion in a patient with metastatic colorectal cancer.
Conclusion A 54-year-old Asian man developed seizure activity requiring emergent intubation during his initial cetuximab infusion for the treatment of metastatic colorectal cancer. PMID: 23111672 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 1, 2012 Category: Drugs & Pharmacology Authors: McClellan NH, Bell WA Tags: Am J Health Syst Pharm Source Type: research
Diphenhydramine/paracetamol/pseudoephedrine: Fixed drug eruption: case report
Source: Reactions - October 31, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research
Cheese: An old drug in a new wrapper
Conclusions: The timely use of multiple data sources enabled this outbreak to be quickly identified and monitored, and the Cheese Heroin Task Force used the collected data to help respond to the problem, although retention in treatment and readmissions remained problematic. Cultural problems including immigration status, language, and misunderstandings about the nature of treatment were barriers to successful treatment outcomes. Completion of treatment as an inhaler is critical to reducing the likelihood of transitioning to injection. (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - October 22, 2012 Category: Addiction Authors: Jane Carlisle Maxwell, John J. Coleman, Sing-Yi Feng, Collin S. Goto, Carlos F. Tirado Tags: Full Length Reports Source Type: research
Toxicological identification of diphenhydramine (DPH) in suicide
This study examines suicidal intoxications with DPH by analyzing blood and gastric content concentration levels. Twenty cases of DPH intoxications within a 10-year period (2000–2010) were discovered by screening the autopsy records of the Institute of Legal Medicine and Forensic Sciences (ILMFS) in Berlin, Germany. In four cases, DPH levels were lower than 1 μg/mL and hence were not considered likely to be responsible for causing death. In 11 cases, DPH played a role in the fatal episode, and five of these cases were monointoxications. Considering that more than 8,000 autopsies were performed by the ILMFS with...
Source: Forensic Science, Medicine, and Pathology - October 12, 2012 Category: Forensic Medicine Tags: Forensic Science, Medicine, and Pathology Source Type: research
Diphenhydramine: Anticholinergic delirium in an elderly patient: case report
Source: Reactions - September 30, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research
Cyclobenzaprine/paracetamol/diphenhydramine overdose: Hepatotoxicity: case report
Source: Reactions - September 28, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research