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Dose-ranging effect of systemic diphenhydramine on postoperative quality of recovery after ambulatory laparoscopic surgery: a randomized, placebo-controlled, double-blinded, clinical trial
Diphenhydramine is an antihistamine with previously demonstrated analgesic and antiemetic properties. However, it is unknown if the beneficial perioperative properties of diphenhydramine can translate to a better quality of postsurgical recovery. The main objective of the current investigation was to investigate dose-ranging effects of diphenhydramine on quality of recovery after surgery. (Source: Journal of Clinical Anesthesia)
Source: Journal of Clinical Anesthesia - April 29, 2016 Category: Anesthesiology Authors: Gildasio S. De Oliveira, Jane Bialek, R.-J. Marcus, Robert McCarthy Tags: Original contribution Source Type: research

Fabrication of CdO/single wall carbon nanotubes modified ionic liquids carbon paste electrode as a high performance sensor in diphenhydramine analysis
We describe a novel DPHA voltammetric sensor, comprising carbon-paste electrode (CPE) modified with CdO/single wall carbon nanotubes (CdO/SWCNTs) nanocomposite and 1-butyl-3-methylimidazolium hexafluoro phosphate ([C4mim]-[PF6]) ionic liquid as binder. CdO/SWCNTs was synthesized by direct chemical precipitation method and characterized with scanning electron microscopy (SEM) and X-ray powder diffraction (XRD) methods. The developed voltammetric sensor displays good catalytic activity toward oxidation of DPHA, which occurs by good electrochemical conductivity of ionic liquid and nanocomposite. The suggested system detects D...
Source: Journal of Molecular Liquids - April 27, 2016 Category: Molecular Biology Source Type: research

The Patient You Least Want to See
Signing my first orders as a medical intern was distinctly disconcerting. Wait, I can just sign this order and it will happen? Are we sure this is safe? Safe or not, new physician trainees suddenly wield the power to administer medications that can be lifesaving or life-ending. Pharmacists corrected my orders for excessive doses of insulin or potassium, while senior physicians guided my selection of vasopressor infusions and antibiotics. When it came to intravenous opioids, however, those same pharmacists never hesitated to approve my orders, and I found little structured guidance from supervising physicians. With no quest...
Source: JAMA - April 26, 2016 Category: Journals (General) Source Type: research

Adverse drug reactions in Nigerian children: a retrospective review of reports submitted to the Nigerian Pharmacovigilance Centre from 2005 to 2012.
CONCLUSION: Anti-infective agents (antibiotics, anti-malarials and anti-retrovirals) were associated with a majority of the ADRs. Stevens-Johnson syndrome was the most frequent severe ADR. Some of the fatalities were associated with sub-standard and herbal medications. PMID: 27077630 [PubMed - as supplied by publisher] (Source: Paediatrics and international child health)
Source: Paediatrics and international child health - April 15, 2016 Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research

Analgesic Effects of 1st Generation Anti-histamines in Mice.
Abstract Pain is sensed, transmitted, and modified by a variety of mediators and receptors. Histamine is a well-known mediator of pain. In addition to their anti-histaminic effects, the classical, or 1st generation, anti-histamines (1st AHs) possess, to various degrees, anti-muscarinic, anti-serotonergic, anti-adrenergic, and other pharmacologic effects. Although there have been attempts to use 1st AHs as analgesics and/or analgesic adjuvants, the advent of non-steroidal anti-inflammatory drugs (NSAIDs) discouraged such trials. We previously reported that in patients with temporomandibular disorders, osteoporosis, ...
Source: Biological and Pharmaceutical Bulletin - April 7, 2016 Category: Drugs & Pharmacology Authors: Takahashi M, Shima K, Tsuchiya M, Hagiwara Y, Mizoguchi H, Sakurada S, Sugawara S, Fujita T, Tadano T, Watanabe M, Fukumoto S, Endo Y Tags: Biol Pharm Bull Source Type: research

Delivery Outcomes After Acute Migraine Treatment in Pregnancy (I5.003)
Conclusions: Pregnant women seeking acute migraine treatment were exposed to a variety of medications, and experienced a higher rate of preterm delivery, preeclampsia and low birthweight but a lower rate of cesarean delivery than the general population. More than half of patients experienced some type of adverse birth outcome, suggesting that pregnancies in such patients should be considered high risk.Disclosure: Dr. Robbins has received personal compensation for activities with Medlink and Prova Education. Dr. Grossman has nothing to disclose. Dr. Govindappagari has nothing to disclose. Dr. Dayal has nothing to disclose. (Source: Neurology)
Source: Neurology - April 4, 2016 Category: Neurology Authors: Robbins, M., Grossman, T., Govindappagari, S., Dayal, A. Tags: Sex-related Factors in Neurological Disease Data Blitz Presentations Source Type: research

Delivery Outcomes After Acute Migraine Treatment in Pregnancy (S26.008)
Conclusions: Pregnant women seeking acute migraine treatment were exposed to a variety of medications, and experienced a higher rate of preterm delivery, preeclampsia and low birthweight but a lower rate of cesarean delivery than the general population. More than half of patients experienced some type of adverse birth outcome, suggesting that pregnancies in such patients should be considered high risk.Disclosure: Dr. Robbins has received personal compensation for activities with Medlink and Prova Education. Dr. Grossman has nothing to disclose. Dr. Govindappagari has nothing to disclose. Dr. Dayal has nothing to disclose. (Source: Neurology)
Source: Neurology - April 4, 2016 Category: Neurology Authors: Robbins, M., Grossman, T., Govindappagari, S., Dayal, A. Tags: Headache Source Type: research

Acute dystonic reaction in a patient with Parkinson’s disease after diphenhydramine withdrawal
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - March 25, 2016 Category: Neurology Source Type: research

A simulated car‐driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers
ConclusionsLevocetirizine and fexofenadine did not impair psychomotor performance in subjects performing simulated car‐driving tasks, while diphenhydramine did impair psychomotor performance in the subjects. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 21, 2016 Category: Psychiatry Authors: Akie Inami, Rin Matsuda, Thomas Grobosch, Hiroshi Komamura, Kazuko Takeda, Yusuke Yamada, Masayasu Miyake, Kotaro Hiraoka, Marcus Maurer, Kazuhiko Yanai, Manabu Tashiro Tags: Research Article Source Type: research

Prevalence of alcohol and drug use in injured British Columbia drivers
Conclusions Alcohol, cannabis and a broad range of other impairing drugs are commonly detected in injured drivers. Alcohol is well known to cause crashes, but further research is needed to determine the impact of other drug use, including drug–alcohol and drug–drug combinations, on crash risk. In particular, more work is needed to understand the role of medications in causing crashes to guide driver education programmes and improve public safety. (Source: BMJ Open)
Source: BMJ Open - March 10, 2016 Category: Journals (General) Authors: Brubacher, J. R., Chan, H., Martz, W., Schreiber, W., Asbridge, M., Eppler, J., Lund, A., Macdonald, S., Drummer, O., Purssell, R., Andolfatto, G., Mann, R., Brant, R. Tags: Open access, Epidemiology, Public health Research Source Type: research

Next‐day residual effects of gabapentin, diphenhydramine, and triazolam on simulated driving performance in healthy volunteers: a phase 3, randomized, double‐blind, placebo‐controlled, crossover trial
ConclusionsTogether, these data suggest that low‐dose gabapentin had no appreciable next‐day effects on simulated driving performance or cognitive functioning. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2016 Category: Psychiatry Authors: Gary G. Kay, Howard I. Schwartz, Mark A. Wingertzahn, Shyamalie Jayawardena, Russell P. Rosenberg Tags: Research Article Source Type: research

In vitro study of histamine and histamine receptor ligands influence on the adhesion of purified human eosinophils to endothelium.
Abstract It is a well-known fact that histamine is involved in eosinophil-dependent inflammatory responses including cellular chemotaxis and migration. Nevertheless, the relative role of histamine receptors in the mechanisms of eosinophils adhesion to endothelial cells is not known. Therefore the aim of presented study was to examine the effect of selective histamine receptors ligands on eosinophils adhesion to endothelium. For that purpose the highly purified human eosinophils have been isolated from the peripheral blood. The viability and functional integrity of isolated eosinophils have been validated in several...
Source: European Journal of Pharmacology - February 29, 2016 Category: Drugs & Pharmacology Authors: Grosicki M, Wójcik T, Chlopicki S, Kieć-Kononowicz K Tags: Eur J Pharmacol Source Type: research

23 years of toxicology testing fatally injured pilots: Implications for aviation and other modes of transportation
This study used the results from these tests to assess drug use in aviation. Methods Using matched data from the FAA’s Civil Aerospace Medical Institute toxicology database and the National Transportation Safety Board’s (NTSB’s) aviation accident database, this study examined trends in the prevalence of over-the-counter, prescription, and illicit drugs identified in toxicology tests of fatally injured pilots between 1990 and 2012. Cases that failed to match or where toxicology testing had not been performed were excluded. Pilots identified by the NTSB investigation as being the “flying pilot” at the time of the ...
Source: Accident Analysis and Prevention - February 28, 2016 Category: Accident Prevention Source Type: research

23 years of toxicology testing fatally injured pilots: Implications for aviation and other modes of transportation.
This study used the results from these tests to assess drug use in aviation. METHODS: Using matched data from the FAA's Civil Aerospace Medical Institute toxicology database and the National Transportation Safety Board's (NTSB's) aviation accident database, this study examined trends in the prevalence of over-the-counter, prescription, and illicit drugs identified in toxicology tests of fatally injured pilots between 1990 and 2012. Cases that failed to match or where toxicology testing had not been performed were excluded. Pilots identified by the NTSB investigation as being the "flying pilot" at the time of the accide...
Source: Accident; Analysis and Prevention. - February 26, 2016 Category: Accident Prevention Authors: McKay MP, Groff L Tags: Accid Anal Prev Source Type: research

Pharmacological characteristics of Artemisia vulgaris L. in isolated porcine basilar artery
Conclusion For the first time, the present study has demonstrated that AVL has two opposite effects, contraction and relaxation, on isolated artery, which may help to explain the conflicting indications for AVL in traditional herbalism. 5-HT is a significant factor affecting artery contraction in the presence of AVL. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 22, 2016 Category: Drugs & Pharmacology Source Type: research

Abstract P1-15-06: Evaluation of miracle mouthwash (MMW) plus hydrocortisone versus prednisolone mouth rinses as prophylaxis for everolimus-associated stomatitis: Preliminary results of a randomized phase II study
Conclusion: These preliminary data are the first from a prospective trial to provide evidence of a reduced incidence of mTOR-associated stomatitis with prophylactic use of a steroid mouth rinse. The 25% incidence of all-grade and 8%/0% incidence of G2/3 stomatitis compare favorably with the 67% and 24%/8% incidence of all-grade and G2/3 stomatitis, respectively, in BOLERO-2. These preliminary data also demonstrated the safety and tolerability of these 2 steroid mouth rinses. The incidence of stomatitis on each study arm will be available when accrual is completed. The prophylactic use of steroid mouth rinses substantially ...
Source: Cancer Research - February 18, 2016 Category: Cancer & Oncology Authors: Jones, V., Jensen, L., McIntyre, K., Oommen, S., Patt, D., Cortas, T., Harris, R., Wilks, S., Fox, P., O'Shaughnessy, J. Tags: Poster Session Abstracts Source Type: research

Prehospital Administration of Epinephrine in Pediatric Anaphylaxis.
Authors: Carrillo E, Hern HG, Barger J Abstract Anaphylaxis in the pediatric population is both serious and potentially lethal. The incidence of allergic and anaphylactic reactions has been increasing and the need for life saving intervention with epinephrine must remain an important part of Emergency Medical Services (EMS) provider training. Our aim was to characterize dosing and timing of epinephrine, diphenhydramine, and albuterol in the pediatric patient with anaphylaxis. In this retrospective chart review, we studied prehospital medication administration in pediatric patients ages 1 month up to 14 years old c...
Source: Prehospital Emergency Care - February 14, 2016 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats
Publication date: Available online 11 February 2016 Source:Journal of Pharmacological Sciences Author(s): Hiroyuki Mizuguchi, Asish K. Das, Kazutaka Maeyama, Shrabanti Dev, Masum Shahriar, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of nasal symptoms. Here, we show that antihistamine suppressed upregulation of histidine decarboxylase (HDC) mRNA expression in patien...
Source: Journal of Pharmacological Sciences - February 12, 2016 Category: Drugs & Pharmacology Source Type: research

Use of an Injectable Diphenhydramine Solution as the Local Anesthetic for Mohs Surgery
No abstract available (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - February 1, 2016 Category: Dermatology Tags: Letters and Communications Source Type: research

A Randomized Controlled Pilot Study Comparing the Impact of Aprepitant and Fosaprepitant on Chemotherapy Induced Nausea and Vomiting in Patients Treated for Gynecologic Cancer
Conclusions: The findings from the current analysis suggest that intravenous fosaprepitant and oral aprepitant confer beneficial antiemetic prevention. Moreover, the 2 medications theoretically afford a favorable impact on daily living, thereby potentially facilitating the completion of a patient’s clinically prescribed chemotherapy regimen. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - January 28, 2016 Category: Cancer & Oncology Tags: Quality of Life Source Type: research

The pharmacokinetics of DPH after the administration of a single intravenous or intramuscular dose in healthy dogs
The objective of this study was to determine the pharmacokinetics of diphenhydramine (DPH) in healthy dogs following a single i.v. or i.m. dose. Dogs were randomly allocated in two treatment groups and received DPH at 1 mg/kg, i.v., or 2 mg/kg, i.m. Blood samples were collected serially over 24 h. Plasma concentrations of DPH were determined by high‐performance liquid chromatography, and noncompartmental pharmacokinetic analysis was performed with the commercially available software. Cardio‐respiratory parameters, rectal temperature and effects on behaviour, such as sedation or excitement, were recorded. Diphenhydra...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 28, 2016 Category: Veterinary Research Authors: A. Sanchez, A. Valverde, M. Sinclair, C. Mosley, A. Singh, A. J. Mutsaers, B. Hanna, Y. Gu, R. Johnson Tags: Scientific Paper Source Type: research

Heliotrope Rash and Gottron Papules in a Child with Juvenile Dermatomyositis
A previously healthy 5-year-old Caucasian female presented with a 2-month history of facial rash, facial swelling, and generalized fatigue. The rash began on her cheeks and spread over her eyes. She was prescribed topical steroids and diphenhydramine for a suspected allergic reaction. The rash continued to progress and she also developed new lesions on her hands and elbows. The child began reporting increasing fatigue and refused to get out of bed secondary to pain in her wrists and hands. She had difficulty climbing stairs and combing her hair. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 23, 2016 Category: Pediatrics Authors: Sukesh Sukumaran, Tiffany Palmer, Vini Vijayan Tags: Rediscovering the Physical Exam Source Type: research

Nalbuphine for Treatment of Opioid-induced Pruritus: A Systematic Review of Literature
Conclusions: Nalbuphine is superior in treating opioid-induced pruritus when compared with placebo, control, diphenhydramine, naloxone, or propofol in patients receiving neuraxial opioids for acute pain related to surgery or childbirth. Therefore, it is recommended that nalbuphine should be used as a first-line treatment of opioid-induced pruritus. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - December 28, 2015 Category: Anesthesiology Tags: Review Article Source Type: research

A High-Performance Thin Layer Chromatography (HPTLC) Method for Simultaneous Determination of Diphenhydramine Hydrochloride and Naproxen Sodium in Tablets.
Abstract A rapid and simple high-performance thin layer chromatography (HPTLC) method with densitometry at 230 nm was developed and validated for simultaneous determination of diphenhydramine hydrochloride (DPH) and naproxen sodium (NPS) from pharmaceutical preparation. The separation was carried out on aluminum plates precoated with silica gel 60 F254 using mobile phase toluene:methanol:glacial acetic acid (7.5:1:0.2, v/v/v). The linearity range lies between 200 and 1200 ng/band for DPH and 1760 and 10,560 ng/band for NPS with correlation coefficients of 0.994 and 0.995, respectively. The R f value for DPH is 0.20 ...
Source: Analytical Chemistry Insights - December 26, 2015 Category: Chemistry Authors: Bhole RP, Shinde SS, Chitlange SS, Wankhede SB Tags: Anal Chem Insights Source Type: research

Risk Factors, Clinical Presentation, and Outcomes in Overdose With Acetaminophen Alone or With Combination Products: Results From the Acute Liver Failure Study Group
Background and Aims: Acetaminophen (APAP) is the most common cause of acute liver failure (ALF) in the west. It is unknown if APAP overdose in combination with diphenhydramine or opioids confers a different clinical presentation or prognosis. Study objectives were to compare (1) baseline patient characteristics; (2) initial clinical presentation; and (3) clinical outcomes among patients with ALF due to APAP alone or in combination with diphenhydramine or opioids. Methods: We analyzed 666 cases of APAP-related liver failure using the Acute Liver Failure Study Group database from 1998 to 2012. The database contains detailed ...
Source: Journal of Clinical Gastroenterology - December 9, 2015 Category: Gastroenterology Tags: LIVER, PANCREAS AND BILIARY TRACT: Original Articles Source Type: research

Serotonergic or Anticholinergic Toxidrome: Case Report of a 9-Year-Old Girl
Conclusions: This case illustrates the importance of differential diagnosis between toxidromes and how clinical presentation can be altered by preexisting conditions as well as the use of medications that affect multiple neurotransmitter systems. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - December 1, 2015 Category: Emergency Medicine Tags: Illustrative Cases Source Type: research

Presence of an H + /Quinidine Antiport System in Madin–Darby Canine Kidney Cells
Conclusions The present findings suggested that the renal new antiport system is involved in the bidirectional membrane transport of quinidine in MDCK cells. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - December 1, 2015 Category: Drugs & Pharmacology Source Type: research

TriCalm(®) hydrogel is significantly superior to 2% diphenhydramine and 1% hydrocortisone in reducing the peak intensity, duration, and overall magnitude of cowhage-induced itch.
CONCLUSION: TriCalm hydrogel has a robust antipruritic effect against nonhistaminergic pruritus induced via the PAR2 pathway, and therefore it could represent a promising treatment option for itch. PMID: 25941445 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - November 30, 2015 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Successful Treatment of Paroxysmal Movement Disorders of Infancy with Dimenhydrinate and Diphenhydramine
Paroxysmal movement disorders including paroxysmal tonic upgaze of infancy and paroxysmal dystonia of infancy are benign but uncommon movement disorders seen in young children. Although symptoms are intermittent and resolve spontaneously, they can cause discomfort and distress for the child. Current treatment options are limited to dopaminergic agents or anticonvulsants with limited efficacy. (Source: Pediatric Neurology)
Source: Pediatric Neurology - November 26, 2015 Category: Neurology Authors: K.M. Sawicka, H. Goez, R.J. Huntsman Tags: Clinical Observations Source Type: research

A Case of Severe Anaphylactic Reaction Secondary to Isosulfan Blue Dye Injection.
CONCLUSION: Sentinel lymph node biopsy is the standard of care for staging several cancers, and isosulfan blue is the dye most commonly used for this procedure. Reactions to the dye occur in some patients; however, we recommend the continued use of isosulfan blue dye for lymph node mapping given the low incidence of adverse effects, with no reported mortalities. Physicians should be prepared for the potential risk of anaphylactic shock. PMID: 26130983 [PubMed] (Source: Ochsner Journal)
Source: Ochsner Journal - November 18, 2015 Category: Journals (General) Tags: Ochsner J Source Type: research

Acetylcysteine for treatment of autism spectrum disorder symptoms.
CONCLUSION: Treatment with acetylcysteine improved ASD symptoms, including irritability and aggression, in a teenage patient. PMID: 26541950 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 7, 2015 Category: Drugs & Pharmacology Authors: Stutzman D, Dopheide J Tags: Am J Health Syst Pharm Source Type: research

Haloperidol for the treatment of nausea and vomiting in palliative care patients.
CONCLUSIONS: Since the last version of this review, we found one new study for inclusion but the conclusion remains unchanged. There is incomplete evidence from published RCTs to determine the effectiveness of haloperidol for nausea and vomiting in palliative care. Other than the trial of ABH gel vs placebo, we did not identify any fully published RCTs exploring the effectiveness of haloperidol for nausea and vomiting in palliative care patients for this update, but two trials are underway. PMID: 26524474 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 2, 2015 Category: Journals (General) Authors: Murray-Brown F, Dorman S Tags: Cochrane Database Syst Rev Source Type: research

Pemetrexed-Associated Eyelid Edema: Effective Treatment by Excision of Lymphedematous Eyelid Tissue
Pemetrexed is an antimetabolite agent that inhibits multiple folate-requiring enzymes and is used in the treatment of mesothelioma and non–small-cell lung cancer. One of its toxicities is isolated cutaneous swelling affecting the eyelids and/or orbit. The pathologic assessment or its management has not been addressed to date. Herein, the authors report a case of a 77-year-old woman treated with pemetrexed for non–small-cell lung adenocarcinoma who developed persistent, severe bilateral lower eyelid swelling for several months, despite compresses and oral diphenhydramine. Elective excision was performed with good result...
Source: Ophthalmic Plastic and Reconstructive Surgery - November 1, 2015 Category: Opthalmology Tags: Case Reports Source Type: research

Sleep Health and Appropriate Use of OTC Sleep Aids in Older Adults-Recommendations of a Gerontological Society of America Workgroup.
Abstract Getting a good night's sleep can be challenging for older adults with chronic medical conditions, which often interfere with sleep. As a result, many older adults turn to over-the-counter (OTC) sleep aids, that is, products with diphenhydramine or doxylamine. However, these products are indicated only for occasional difficulty with sleep, not for chronic use; and their safety and efficacy has not been well established in general and in older adults specifically. To engage national stakeholders in a discussion of OTC sleep aids in older adults, the Gerontological Society of America (GSA) convened a multidis...
Source: The Gerontologist - October 28, 2015 Category: Geriatrics Authors: Albert SM, Roth T, Toscani M, Vitiello MV, Zee P Tags: Gerontologist Source Type: research

Age But Not Sex Is Associated With Efficacy and Adverse Events Following Administration of Intravenous Migraine Medication: An Analysis of a Clinical Trial Database.
CONCLUSION: Sex was not associated with response to parenteral acute migraine medication. Age was associated with both efficacy and adverse events. PMID: 26486928 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - October 21, 2015 Category: Neurology Authors: Friedman BW, Cisewski DH, Holden L, Bijur PE, Gallagher EJ Tags: Headache Source Type: research

Age But Not Sex Is Associated With Efficacy and Adverse Events Following Administration of Intravenous Migraine Medication: An Analysis of a Clinical Trial Database
ConclusionSex was not associated with response to parenteral acute migraine medication. Age was associated with both efficacy and adverse events. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 21, 2015 Category: Neurology Authors: Benjamin W. Friedman, David H. Cisewski, Lynne Holden, Polly E. Bijur, E. John Gallagher Tags: Research Submissions Source Type: research

Correlation and thermodynamic analysis of solubility of diphenhydramine hydrochloride in pure and binary solvents
Publication date: February 2016 Source:The Journal of Chemical Thermodynamics, Volume 93 Author(s): Shichao Du, Yan Wang, Jianyu Li, Songgu Wu, Weiqiang Dun, Xiaopeng Song, Jingkang Wang, Junbo Gong The solubility of diphenhydramine hydrochloride (DH) in four pure solvents (methanol, ethanol, acetone and ethyl acetate) and two binary solvents (ethanol+ethyl acetate) and (ethanol+acetone) was determined at temperatures from (278.15 to 323.15)K. The experimental solubility of DH is well correlated by the modified Apelblat equation, the CNIBS/R-K equation and the hybrid model, respectively. All the measured solubili...
Source: The Journal of Chemical Thermodynamics - October 20, 2015 Category: Chemistry Source Type: research

Pharmacophore‐based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line
Conclusions and ImplicationsThe pharmacophore model for the proton‐antiporter inhibitors was a good predictor of known inhibitors and allowed us to identify new good inhibitors. This model marks a new step towards the discovery of this drug/proton antiporter and will be of great use for the discovery and design of potent inhibitors that could potentially help to assess and validate its pharmacological role in drug addiction in vivo. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - October 13, 2015 Category: Drugs & Pharmacology Authors: Hélène Chapy, Laura Goracci, Philippe Vayer, Yannick Parmentier, Pierre‐Alain Carrupt, Xavier Declèves, Jean‐Michel Scherrmann, Salvatore Cisternino, Gabriele Cruciani Tags: RESEARCH PAPER Source Type: research

A comprehensive and sensitive method for hair analysis in drug-facilitated crimes and incorporation of zolazepam and tiletamine into hair after a single exposure.
Abstract Hair is a highly relevant specimen that is used to verify drug exposure in victims of drug-facilitated crime (DFC) cases. In the present study, a new analytical method involving ultrahigh-performance liquid chromatography-tandem mass spectrometry was developed for determining the presence of model drugs, including zolazepam and tiletamine and their metabolites in hair specimens from DFCs. The incorporation of zolazepam and tiletamine into hair after a single exposure was investigated in Long-Evans rats with the ratio of the hair concentration to the area under the curve. For rapid and simple sample prepara...
Source: Analytical and Bioanalytical Chemistry - October 10, 2015 Category: Chemistry Authors: Kim J, Yum H, Jang M, Shin I, Yang W, Baeck S, Suh JH, Lee S, Han SB Tags: Anal Bioanal Chem Source Type: research

Long-term use of diphenhydramine.
Authors: Wong HC PMID: 26438591 [PubMed - in process] (Source: Canadian Medical Association Journal)
Source: Canadian Medical Association Journal - October 7, 2015 Category: Journals (General) Tags: CMAJ Source Type: research

Trends in Emergency Department Visits for Unsupervised Pediatric Medication Exposures, 2004-2013
CONCLUSIONS: Targeting prevention efforts based on harm frequency and intervention feasibility can lead to continued reductions in ED visits for pediatric medication exposures. (Source: PEDIATRICS)
Source: PEDIATRICS - October 1, 2015 Category: Pediatrics Authors: Lovegrove, M. C., Weidle, N. J., Budnitz, D. S. Tags: Injury, Violence & Poison Prevention, Preventative Medicine Article Source Type: research

Age matters: Developmental stage of Danio rerio larvae influences photomotor response thresholds to diazinion or diphenhydramine
Publication date: Available online 25 September 2015 Source:Aquatic Toxicology Author(s): Lauren A. Kristofco, Luis Colon Cruz, Samuel P. Haddad, Martine L. Behra, C. Kevin Chambliss, Bryan W. Brooks Because basic toxicological data is unavailable for the majority of industrial compounds, High Throughput Screening (HTS) assays using the embryonic and larval zebrafish provide promising approaches to define bioactivity profiles and identify potential adverse outcome pathways for previously understudied chemicals. Unfortunately, standardized approaches, including HTS experimental designs, for examining fish behavioral...
Source: Aquatic Toxicology - September 26, 2015 Category: Toxicology Source Type: research

Age matters: Developmental stage of Danio rerio larvae influences photomotor response thresholds to diazinion or diphenhydramine.
Abstract Because basic toxicological data is unavailable for the majority of industrial compounds, High Throughput Screening (HTS) assays using the embryonic and larval zebrafish provide promising approaches to define bioactivity profiles and identify potential adverse outcome pathways for previously understudied chemicals. Unfortunately, standardized approaches, including HTS experimental designs, for examining fish behavioral responses to contaminants are rarely available. In the present study, we examined movement behavior of larval zebrafish over 7 days (4-10 days post fertilization or dpf) during typical dayli...
Source: Aquatic Toxicology - September 25, 2015 Category: Toxicology Authors: Kristofco LA, Cruz LC, Haddad SP, Behra ML, Chambliss CK, Brooks BW Tags: Aquat Toxicol Source Type: research

Adverse drug reactions in Nigerian children: a retrospective review of reports submitted to the Nigerian Pharmacovigilance Centre from 2005 to 2012.
CONCLUSION: Anti-infective agents (antibiotics, anti-malarials and anti-retrovirals) were associated with a majority of the ADRs. Stevens-Johnson syndrome was the most frequent severe ADR. Some of the fatalities were associated with sub-standard and herbal medications. PMID: 26384567 [PubMed - as supplied by publisher] (Source: Paediatrics and international child health)
Source: Paediatrics and international child health - September 21, 2015 Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research

272 cases of rattlesnake envenomation in dogs: Demographics and treatment including safety of F(ab')2 antivenom use in 236 patients.
The objectives were to examine the patient demographics, severity of clinical signs, and treatment modalities employed, in order to discuss the outcomes of certain therapies including glucocorticoid use, antibiotic use, rattlesnake vaccination, and safety of antivenom administration in dogs. Evaluation was performed to model each response (survival, proposed canine snakebite severity score (cSSS), and length of stay) as a function of multiple variables. Of the 272 bite incidences, 8 dogs had a fatal outcome. In dogs older than 10 years, there was a greater likelihood of fatal outcome associated with a longer delay between ...
Source: Toxicon - September 1, 2015 Category: Toxicology Authors: Witsil AJ, Wells RJ, Woods C, Rao S Tags: Toxicon Source Type: research

Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department–Based Randomized Clinical Trial
Conclusion Intravenous diphenhydramine, when administered as adjuvant therapy with metoclopramide, does not improve migraine outcomes. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - August 30, 2015 Category: Emergency Medicine Source Type: research

Sensitivity and specificity of intrathecal fluorescein and white light excitation for detecting intraoperative cerebrospinal fluid leak in endoscopic skull base surgery: a prospective study.
CONCLUSIONS ITF is extremely specific and very sensitive for detecting intraoperative CSF leaks. Although false negatives can occur, these patients do not appear to be at risk for postoperative CSF leak. The use of ITF may help surgeons prevent postoperative CSF leaks by intraoperatively detecting and confirming a watertight repair. PMID: 26295912 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - August 21, 2015 Category: Neurosurgery Authors: Raza SM, Banu MA, Donaldson A, Patel KS, Anand VK, Schwartz TH Tags: J Neurosurg Source Type: research

Open Channel Block of NMDA Receptors by Diphenhydramine.
CONCLUSION AND IMPLICATIONS: The data presented here provide evidence that the NMDA receptor antagonism of diphenhydramine contribute to its sedative and potentially LTP-related effects like analgesia and amnesia. PMID: 26284492 [PubMed - as supplied by publisher] (Source: Neuropharmacology)
Source: Neuropharmacology - August 15, 2015 Category: Drugs & Pharmacology Authors: Föhr KJ, Zeller K, Georgieff M, Köster S, Adolph O Tags: Neuropharmacology Source Type: research

Pharmacophore‐based discovery of inhibitors of a novel drug proton‐antiporter in human brain endothelial hCMEC/D3 cell line
Conclusions and implicationsThe pharmacophore model for the proton‐antiporter inhibitors was a good predictor of known inhibitors and allowed to identify new good inhibitors. This model marks a new step toward the discovery of this drug/proton‐antiporter and will be of great use for the discovery and design of stronger inhibitors that could potentially help to assess and validate its pharmacological role in drug addiction by inhibition strategy in vivo. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - July 29, 2015 Category: Drugs & Pharmacology Authors: Hélène Chapy, Laura Goracci, Philippe Vayer, Yannick Parmentier, Pierre‐Alain Carrupt, Xavier Declèves, Jean‐Michel Scherrmann, Salvatore Cisternino, Gabriele Cruciani Tags: RESEARCH PAPER Source Type: research

Clindamycin-induced hypersensitivity reaction
We report the case of a 46-year-old female who experienced anaphylaxis after a dose of intravenous (IV) clindamycin. Following treatment with methylprednisolone, epinephrine, diphenhydramine, and albuterol, the patient stabilized. The patient’s score on the Naranjo’s algorithm was 8 (probable); a score of 9 (definite) limited only by absence of drug re-challenge. To our knowledge, this is the first report of a clindamycin-induced anaphylaxis where the patient was not exposed to any other agent that may have triggered the response, the first case in the United States, and only the third documented case in the litera...
Source: Infection - July 28, 2015 Category: Infectious Diseases Source Type: research