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A Case of Severe Anaphylactic Reaction Secondary to Isosulfan Blue Dye Injection.
CONCLUSION: Sentinel lymph node biopsy is the standard of care for staging several cancers, and isosulfan blue is the dye most commonly used for this procedure. Reactions to the dye occur in some patients; however, we recommend the continued use of isosulfan blue dye for lymph node mapping given the low incidence of adverse effects, with no reported mortalities. Physicians should be prepared for the potential risk of anaphylactic shock. PMID: 26130983 [PubMed] (Source: Ochsner Journal)
Source: Ochsner Journal - November 18, 2015 Category: Journals (General) Tags: Ochsner J Source Type: research
Acetylcysteine for treatment of autism spectrum disorder symptoms.
CONCLUSION: Treatment with acetylcysteine improved ASD symptoms, including irritability and aggression, in a teenage patient. PMID: 26541950 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 7, 2015 Category: Drugs & Pharmacology Authors: Stutzman D, Dopheide J Tags: Am J Health Syst Pharm Source Type: research
Haloperidol for the treatment of nausea and vomiting in palliative care patients.
CONCLUSIONS: Since the last version of this review, we found one new study for inclusion but the conclusion remains unchanged. There is incomplete evidence from published RCTs to determine the effectiveness of haloperidol for nausea and vomiting in palliative care. Other than the trial of ABH gel vs placebo, we did not identify any fully published RCTs exploring the effectiveness of haloperidol for nausea and vomiting in palliative care patients for this update, but two trials are underway. PMID: 26524474 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 2, 2015 Category: Journals (General) Authors: Murray-Brown F, Dorman S Tags: Cochrane Database Syst Rev Source Type: research
Pemetrexed-Associated Eyelid Edema: Effective Treatment by Excision of Lymphedematous Eyelid Tissue
Pemetrexed is an antimetabolite agent that inhibits multiple folate-requiring enzymes and is used in the treatment of mesothelioma and non–small-cell lung cancer. One of its toxicities is isolated cutaneous swelling affecting the eyelids and/or orbit. The pathologic assessment or its management has not been addressed to date. Herein, the authors report a case of a 77-year-old woman treated with pemetrexed for non–small-cell lung adenocarcinoma who developed persistent, severe bilateral lower eyelid swelling for several months, despite compresses and oral diphenhydramine. Elective excision was performed with good result...
Source: Ophthalmic Plastic and Reconstructive Surgery - November 1, 2015 Category: Opthalmology Tags: Case Reports Source Type: research
Sleep Health and Appropriate Use of OTC Sleep Aids in Older Adults-Recommendations of a Gerontological Society of America Workgroup.
Abstract Getting a good night's sleep can be challenging for older adults with chronic medical conditions, which often interfere with sleep. As a result, many older adults turn to over-the-counter (OTC) sleep aids, that is, products with diphenhydramine or doxylamine. However, these products are indicated only for occasional difficulty with sleep, not for chronic use; and their safety and efficacy has not been well established in general and in older adults specifically. To engage national stakeholders in a discussion of OTC sleep aids in older adults, the Gerontological Society of America (GSA) convened a multidis...
Source: The Gerontologist - October 28, 2015 Category: Geriatrics Authors: Albert SM, Roth T, Toscani M, Vitiello MV, Zee P Tags: Gerontologist Source Type: research
Age But Not Sex Is Associated With Efficacy and Adverse Events Following Administration of Intravenous Migraine Medication: An Analysis of a Clinical Trial Database.
CONCLUSION: Sex was not associated with response to parenteral acute migraine medication. Age was associated with both efficacy and adverse events. PMID: 26486928 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - October 21, 2015 Category: Neurology Authors: Friedman BW, Cisewski DH, Holden L, Bijur PE, Gallagher EJ Tags: Headache Source Type: research
Age But Not Sex Is Associated With Efficacy and Adverse Events Following Administration of Intravenous Migraine Medication: An Analysis of a Clinical Trial Database
ConclusionSex was not associated with response to parenteral acute migraine medication. Age was associated with both efficacy and adverse events. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 21, 2015 Category: Neurology Authors: Benjamin W. Friedman, David H. Cisewski, Lynne Holden, Polly E. Bijur, E. John Gallagher Tags: Research Submissions Source Type: research
Correlation and thermodynamic analysis of solubility of diphenhydramine hydrochloride in pure and binary solvents
Publication date: February 2016 Source:The Journal of Chemical Thermodynamics, Volume 93 Author(s): Shichao Du, Yan Wang, Jianyu Li, Songgu Wu, Weiqiang Dun, Xiaopeng Song, Jingkang Wang, Junbo Gong The solubility of diphenhydramine hydrochloride (DH) in four pure solvents (methanol, ethanol, acetone and ethyl acetate) and two binary solvents (ethanol+ethyl acetate) and (ethanol+acetone) was determined at temperatures from (278.15 to 323.15)K. The experimental solubility of DH is well correlated by the modified Apelblat equation, the CNIBS/R-K equation and the hybrid model, respectively. All the measured solubili...
Source: The Journal of Chemical Thermodynamics - October 20, 2015 Category: Chemistry Source Type: research
Pharmacophore‐based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line
Conclusions and ImplicationsThe pharmacophore model for the proton‐antiporter inhibitors was a good predictor of known inhibitors and allowed us to identify new good inhibitors. This model marks a new step towards the discovery of this drug/proton antiporter and will be of great use for the discovery and design of potent inhibitors that could potentially help to assess and validate its pharmacological role in drug addiction in vivo. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - October 13, 2015 Category: Drugs & Pharmacology Authors: Hélène Chapy, Laura Goracci, Philippe Vayer, Yannick Parmentier, Pierre‐Alain Carrupt, Xavier Declèves, Jean‐Michel Scherrmann, Salvatore Cisternino, Gabriele Cruciani Tags: RESEARCH PAPER Source Type: research
A comprehensive and sensitive method for hair analysis in drug-facilitated crimes and incorporation of zolazepam and tiletamine into hair after a single exposure.
Abstract Hair is a highly relevant specimen that is used to verify drug exposure in victims of drug-facilitated crime (DFC) cases. In the present study, a new analytical method involving ultrahigh-performance liquid chromatography-tandem mass spectrometry was developed for determining the presence of model drugs, including zolazepam and tiletamine and their metabolites in hair specimens from DFCs. The incorporation of zolazepam and tiletamine into hair after a single exposure was investigated in Long-Evans rats with the ratio of the hair concentration to the area under the curve. For rapid and simple sample prepara...
Source: Analytical and Bioanalytical Chemistry - October 10, 2015 Category: Chemistry Authors: Kim J, Yum H, Jang M, Shin I, Yang W, Baeck S, Suh JH, Lee S, Han SB Tags: Anal Bioanal Chem Source Type: research
Long-term use of diphenhydramine.
Authors: Wong HC PMID: 26438591 [PubMed - in process] (Source: Canadian Medical Association Journal)
Source: Canadian Medical Association Journal - October 7, 2015 Category: Journals (General) Tags: CMAJ Source Type: research
Trends in Emergency Department Visits for Unsupervised Pediatric Medication Exposures, 2004-2013
CONCLUSIONS: Targeting prevention efforts based on harm frequency and intervention feasibility can lead to continued reductions in ED visits for pediatric medication exposures. (Source: PEDIATRICS)
Source: PEDIATRICS - October 1, 2015 Category: Pediatrics Authors: Lovegrove, M. C., Weidle, N. J., Budnitz, D. S. Tags: Injury, Violence & Poison Prevention, Preventative Medicine Article Source Type: research
Age matters: Developmental stage of Danio rerio larvae influences photomotor response thresholds to diazinion or diphenhydramine
Publication date: Available online 25 September 2015 Source:Aquatic Toxicology Author(s): Lauren A. Kristofco, Luis Colon Cruz, Samuel P. Haddad, Martine L. Behra, C. Kevin Chambliss, Bryan W. Brooks Because basic toxicological data is unavailable for the majority of industrial compounds, High Throughput Screening (HTS) assays using the embryonic and larval zebrafish provide promising approaches to define bioactivity profiles and identify potential adverse outcome pathways for previously understudied chemicals. Unfortunately, standardized approaches, including HTS experimental designs, for examining fish behavioral...
Source: Aquatic Toxicology - September 26, 2015 Category: Toxicology Source Type: research
Age matters: Developmental stage of Danio rerio larvae influences photomotor response thresholds to diazinion or diphenhydramine.
Abstract Because basic toxicological data is unavailable for the majority of industrial compounds, High Throughput Screening (HTS) assays using the embryonic and larval zebrafish provide promising approaches to define bioactivity profiles and identify potential adverse outcome pathways for previously understudied chemicals. Unfortunately, standardized approaches, including HTS experimental designs, for examining fish behavioral responses to contaminants are rarely available. In the present study, we examined movement behavior of larval zebrafish over 7 days (4-10 days post fertilization or dpf) during typical dayli...
Source: Aquatic Toxicology - September 25, 2015 Category: Toxicology Authors: Kristofco LA, Cruz LC, Haddad SP, Behra ML, Chambliss CK, Brooks BW Tags: Aquat Toxicol Source Type: research
Adverse drug reactions in Nigerian children: a retrospective review of reports submitted to the Nigerian Pharmacovigilance Centre from 2005 to 2012.
CONCLUSION: Anti-infective agents (antibiotics, anti-malarials and anti-retrovirals) were associated with a majority of the ADRs. Stevens-Johnson syndrome was the most frequent severe ADR. Some of the fatalities were associated with sub-standard and herbal medications. PMID: 26384567 [PubMed - as supplied by publisher] (Source: Paediatrics and international child health)
Source: Paediatrics and international child health - September 21, 2015 Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
272 cases of rattlesnake envenomation in dogs: Demographics and treatment including safety of F(ab')2 antivenom use in 236 patients.
The objectives were to examine the patient demographics, severity of clinical signs, and treatment modalities employed, in order to discuss the outcomes of certain therapies including glucocorticoid use, antibiotic use, rattlesnake vaccination, and safety of antivenom administration in dogs. Evaluation was performed to model each response (survival, proposed canine snakebite severity score (cSSS), and length of stay) as a function of multiple variables. Of the 272 bite incidences, 8 dogs had a fatal outcome. In dogs older than 10 years, there was a greater likelihood of fatal outcome associated with a longer delay between ...
Source: Toxicon - September 1, 2015 Category: Toxicology Authors: Witsil AJ, Wells RJ, Woods C, Rao S Tags: Toxicon Source Type: research
Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department–Based Randomized Clinical Trial
Conclusion Intravenous diphenhydramine, when administered as adjuvant therapy with metoclopramide, does not improve migraine outcomes. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - August 30, 2015 Category: Emergency Medicine Source Type: research
Sensitivity and specificity of intrathecal fluorescein and white light excitation for detecting intraoperative cerebrospinal fluid leak in endoscopic skull base surgery: a prospective study.
CONCLUSIONS ITF is extremely specific and very sensitive for detecting intraoperative CSF leaks. Although false negatives can occur, these patients do not appear to be at risk for postoperative CSF leak. The use of ITF may help surgeons prevent postoperative CSF leaks by intraoperatively detecting and confirming a watertight repair. PMID: 26295912 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - August 21, 2015 Category: Neurosurgery Authors: Raza SM, Banu MA, Donaldson A, Patel KS, Anand VK, Schwartz TH Tags: J Neurosurg Source Type: research
Open Channel Block of NMDA Receptors by Diphenhydramine.
CONCLUSION AND IMPLICATIONS: The data presented here provide evidence that the NMDA receptor antagonism of diphenhydramine contribute to its sedative and potentially LTP-related effects like analgesia and amnesia. PMID: 26284492 [PubMed - as supplied by publisher] (Source: Neuropharmacology)
Source: Neuropharmacology - August 15, 2015 Category: Drugs & Pharmacology Authors: Föhr KJ, Zeller K, Georgieff M, Köster S, Adolph O Tags: Neuropharmacology Source Type: research
Pharmacophore‐based discovery of inhibitors of a novel drug proton‐antiporter in human brain endothelial hCMEC/D3 cell line
Conclusions and implicationsThe pharmacophore model for the proton‐antiporter inhibitors was a good predictor of known inhibitors and allowed to identify new good inhibitors. This model marks a new step toward the discovery of this drug/proton‐antiporter and will be of great use for the discovery and design of stronger inhibitors that could potentially help to assess and validate its pharmacological role in drug addiction by inhibition strategy in vivo. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - July 29, 2015 Category: Drugs & Pharmacology Authors: Hélène Chapy, Laura Goracci, Philippe Vayer, Yannick Parmentier, Pierre‐Alain Carrupt, Xavier Declèves, Jean‐Michel Scherrmann, Salvatore Cisternino, Gabriele Cruciani Tags: RESEARCH PAPER Source Type: research
Clindamycin-induced hypersensitivity reaction
We report the case of a 46-year-old female who experienced anaphylaxis after a dose of intravenous (IV) clindamycin. Following treatment with methylprednisolone, epinephrine, diphenhydramine, and albuterol, the patient stabilized. The patient’s score on the Naranjo’s algorithm was 8 (probable); a score of 9 (definite) limited only by absence of drug re-challenge. To our knowledge, this is the first report of a clindamycin-induced anaphylaxis where the patient was not exposed to any other agent that may have triggered the response, the first case in the United States, and only the third documented case in the litera...
Source: Infection - July 28, 2015 Category: Infectious Diseases Source Type: research
Induction aND ANTAGONISM OF PICA INDUCED bY TERIPARATIDE IN RATS.
In this study, we investigated the characteristics of teriparatide-induced pica and the abilities of anti-emetic drugs to inhibit teriparatide-induced pica. Male and female adolescent (4-week-old), young (8-week-old), and adult (30-week-old) naive rats, and ovariectomized (OVX: 17-week-old) and sham-operated (17-week-old) rats subcutaneously received teriparatide (0.4mg/kg, n=4), and their kaolin and food intakes were monitored for 24h after the injection. Among the tested rats, we found that OVX rats, rather than male, female, and sham-operated rats, showed marked teriparatide-induced pica (0mg/kg: 0.17±0.07g, 0.4mg/kg: ...
Source: European Journal of Pharmacology - July 16, 2015 Category: Drugs & Pharmacology Authors: Yamamoto K, Kato N, Isogai Y, Kuroda T, Ishida T, Yamatodani A Tags: Eur J Pharmacol Source Type: research
A polyspecific drug/proton antiporter mediates diphenhydramine and clonidine transport at the mouse blood‐retinal barrier
Conclusions and implicationsA proton‐antiporter is physiologically involved in the transport of clonidine and diphenhydramine and is quantitatively more important than their passive diffusion flux at the mouse BRB. The features of this molecularly unidentified transporter highlight its importance in regulating drug delivery at the retina and suggest that it has the capacity to handle several drugs. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - July 14, 2015 Category: Drugs & Pharmacology Authors: Hélène Chapy, Pascal André, Xavier Declèves, Jean‐Michel Scherrmann, Salvatore Cisternino Tags: Research Paper Source Type: research
A Literature Review of the Use of Sodium Bicarbonate for the Treatment of QRS Widening.
This article will also address the literature supporting an increased serum sodium concentration, alkalemia, or the combination of both as the responsible mechanism(s) for sodium bicarbonate's antidotal properties. While sodium bicarbonate has been used as a treatment for cardiac sodium channel blockade for multiple other agents including citalopram, cocaine, flecainide, diphenhydramine, propoxyphene, and lamotrigine, it has uncertain efficacy with bupropion, propranolol, and taxine-containing plants. PMID: 26159649 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 10, 2015 Category: Toxicology Authors: Bruccoleri RE, Burns MM Tags: J Med Toxicol Source Type: research
Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model
Conclusion In our study of diphenhydramine-induced hypotensive swine, we found no difference in hypotension, QRS widening, or diphenhydramine levels in aqueous layers between intravenous lipid emulsion and sodium bicarbonate. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - July 10, 2015 Category: Emergency Medicine Source Type: research
Diphenhydramine and QT prolongation – A rare cardiac side effect of a drug used in common practice
We describe a case of a patient who developed QT prolongation with a temporal association with diphenhydramine usage.> (Source: Journal of Cardiology Cases)
Source: Journal of Cardiology Cases - July 4, 2015 Category: Cardiology Source Type: research
Interactions between histamine H1 receptor and its antagonists by using cell membrane chromatography method
ConclusionsThe studies showed CMC could be applied to investigate drug–receptor interactions. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 1, 2015 Category: Drugs & Pharmacology Authors: Weina Ma, Dongdong Zhang, Jing Li, Delu Che, Rui Liu, Jie Zhang, Yanmin Zhang Tags: Research Paper Source Type: research
Pulse‐Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs
Conclusions and clinical importanceCombined treatment with pulse‐administered TOC and lomustine generally is well tolerated and may be a reasonable treatment option for dogs with unresectable or metastatic MCT. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - June 25, 2015 Category: Veterinary Research Authors: J.H. Burton, R.O. Venable, D.M. Vail, L.E. Williams, C.A. Clifford, S.M. Axiak‐Bechtel, A.C. Avery, D.H. Thamm Tags: Standard Article Source Type: research
Stimulatory effects of histamine on migration of nasal fibroblasts
ConclusionWe showed that histamine stimulates fibroblast migration in nasal fibroblasts. This effect appeared to be mediated by HR1 and HR4. However, because fibroblast migration also can be involved in scaring and fibrosis, more research is necessary to determine the effects of antihistamine on wound healing after sinus surgery. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 10, 2015 Category: Allergy & Immunology Authors: Sung‐Moon Hong, Il‐Ho Park, Ji‐Young Um, Jae‐Min Shin, Heung‐Man Lee Tags: ORIGINAL ARTICLE Source Type: research
Identification of position isomers by energy‐resolved mass spectrometry
This study reports an energy‐resolved mass spectrometric (ERMS) strategy for the characterization of position isomers derived from the reaction of hydroxyl radicals (●OH) with diphenhydramine (DPH) that are usually hard to differentiate by other methods. The isomer analogues formed by ●OH attack on the side chain of DPH are identified with the help of a specific fragment ion peak (m/z 88) in the collision‐induced dissociation (CID) spectrum of the protonated molecule. In the negative ion mode, the breakdown curves of the deprotonated molecules show an order of stability (supported by density functional theory (DFT)...
Source: Journal of Mass Spectrometry - June 8, 2015 Category: Chemistry Authors: Sunil Paul M. Menachery, Olivier Laprévote, Thao P. Nguyen, Usha K. Aravind, Pramod Gopinathan, Charuvila T. Aravindakumar Tags: Research article Source Type: research
Pharmaceuticals in grocery market fish fillets by gas chromatography–mass spectrometry
Publication date: 1 January 2016 Source:Food Chemistry, Volume 190 Author(s): Musavvir Arafat Mottaleb , Carly Stowe , Daniel R. Johnson , Mohammed J. Meziani , M. Abdul Mottaleb Occurrences of pharmaceuticals are evident in aquatic organisms. A reproducible gas chromatography–mass spectrometry (GC–MS) method using selected ion monitoring (SIM) has been used to determine the anti-histamine diphenhydramine (DPH), anti-anxiety diazepam (DZP), anti-seizure carbamazepine (CZP) drugs and their metabolites in grocery stores fish that were homogenized, extracted, pre-concentrated, cleaned up, and examined. Identifications o...
Source: Food Chemistry - June 7, 2015 Category: Food Science Source Type: research
Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus.
This study further examined the components of the phase-separated layers using magnetic resonance (MR) spectroscopy and chemical shift selective images, and it was verified that the upper layer consisted of packed oil droplet layers, whereas the lower was an aqueous phase. Subsequently, the time-dependent phase separation of the sample at different temperatures was investigated. From the MR images, including a T2 relaxation time map and apparent diffusion coefficient maps, it was obvious that the phase separation developed further with increasing temperature; the most substantial phase separation was observed from the samp...
Source: Chemical and Pharmaceutical Bulletin - June 2, 2015 Category: Drugs & Pharmacology Authors: Onuki Y, Machida Y, Yokawa T, Seike C, Sakurai S, Takayama K Tags: Chem Pharm Bull (Tokyo) Source Type: research
A novel HPLC–MS/MS method for the simultaneous determination of astemizole and its major metabolite in dog or monkey plasma and application to pharmacokinetics
This report describes a novel high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method for simultaneously determining the concentrations of AST and DEA in beagle dog and cynomolgus monkey plasma with simple preparation method and short retention time. Prior to HPLC analyses, the plasma samples were extracted with simple liquid–liquid extraction method. The isocratic mobile phase was 0.025% trifluoroacetic acid (TFA dissolved in acetonitrile) and 20mM ammonium acetate (94:6) at a flow rate of 0.25mL/min and diphenhydramine used as internal standard. In MS/MS analyses, precursor ions of the a...
Source: Journal of Pharmaceutical and Biomedical Analysis - May 31, 2015 Category: Drugs & Pharmacology Source Type: research
A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs.
Abstract Dextromethorphan (DXM) and diphenhydramine (DPH) are two commonly used over-the-counter non-narcotic antitussive drugs. Recent reports reveal the widespread abuse of DXM and DPH due to their euphoric and alcohol-like effects. Due to their medicinal importance as well as the apparent increase in their use as abused drugs, it has become critical to determine them in samples of biological, clinical and pharmaceutical interest. The electrochemical techniques for drug analysis have gathered considerable attention due to their pronounced selectivity, sensitivity and simplicity. The given review presents a compil...
Source: Talanta - May 27, 2015 Category: Chemistry Authors: Thapliyal N, Patel H, Karpoormath R, Goyal RN, Patel R Tags: Talanta Source Type: research
The Case Files: Face and Neck Swelling Hint at a Daunting Diagnosis
By Mohammed Hassan-Ali, MSC & Ahmed Raziuddin, MD A 56-year-old black man presented to the ED complaining of face and neck swelling. An initial history was difficult to obtain because the patient did not speak English fluently and had slurred speech. Symptoms started approximately a week earlier when the patient was at his nursing home. He denied dysphagia or odynophagia, he had no rashes, pruritus, dyspnea, or peripheral edema, his face was flushed, and he had visibly-engorged neck veins. He noticed that his tongue was mildly swollen, so he took Benadryl for a week with no relief. The patient said he believed that th...
Source: The Case Files - May 26, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Chiral separation of (d)- and (l)-enantiomers of doxylamine succinate in rat plasma
Publication date: Available online 16 May 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Tadiboyina Sirisha , Bannimath Gurupadayya , Bharathkumar Inturi A selective chiral ultra fast liquid chromatography (UFLC-DAD) method was developed and validated to separate and quantify the (d)- and (l)-enantiomers of doxylamine in rat plasma. After extraction of the plasma samples with acetonitrile, the separation of doxylamine succinate enantiomers and internal standard (I.S., diphenhydramine hydrochloride) was achieved on a cellulose Tris (4-chloro,3-methylphenylcarbamate) column with a mobile phase of ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - May 17, 2015 Category: Drugs & Pharmacology Source Type: research
Evaluation of sol–gel TiO2 photocatalysts modified with carbon or boron compounds and crystallized in nitrogen or air atmospheres
Publication date: 1 October 2015 Source:Chemical Engineering Journal, Volume 277 Author(s): Alejandro Ansón-Casaos , Maria J. Sampaio , Clara Jarauta-Córdoba , M. Teresa Martínez , Cláudia G. Silva , Joaquim L. Faria , Adrián M.T. Silva Sol–gel TiO2 photocatalysts are synthesized from titanium isopropoxide and crystallized by thermal treatment under either air atmosphere or nitrogen flow. Reference TiO2 photocatalysts crystallized at 550°C for 30min in air are the most active for the degradation of diphenhydramine pharmaceutical (DPH). In addition, TiO2 precursors are modified with carbon or boron compounds. The ...
Source: Chemical Engineering Journal - May 15, 2015 Category: Chemistry Source Type: research
Direct injection of tissue extracts in liquid chromatography/tandem mass spectrometry for the determination of pharmaceuticals and other contaminants of emerging concern in mollusks.
Abstract In the present study, a straightforward approach was validated for the analysis of pharmaceutically active compounds and endocrine-disrupting chemicals in the mollusk tissues, with a focus on two species commonly consumed in Southeast Asia (green mussels: Perna viridis; lokan clams: Polymesoda expansa). This approach relied on a simple solvent extraction (shaker table) followed by direct injection in liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). This "cleanup-free" approach was made possible by the use of isotopically labeled surrogates (to correct for matrix effects) and a post-col...
Source: Analytical and Bioanalytical Chemistry - May 13, 2015 Category: Chemistry Authors: Bayen S, Estrada ES, Juhel G, Kelly BC Tags: Anal Bioanal Chem Source Type: research
Multidrug-related leukocytoclastic vasculitis raising suspicion of sexual homicide—things are not always what they seem
We report the case of a 35-year-old female deceased who had suffered from a borderline personality and depressive disorder with suicidal ideation. At the death scene, the body showed massive facial swelling accompanied by complete reddening of the skin of the face, with patchy skin abrasions on the forehead and neck, and purple bruise-like discolorations distributed symmetrically over both shoulders, elbows, hands, hips, knees, lower legs, and feet, raising the suspicion of underlying massive external blunt force injury. Police investigators strongly suspected sexual homicide. At autopsy, dissection in layers revealed mass...
Source: International Journal of Legal Medicine - May 10, 2015 Category: Medical Law Source Type: research
Sedation and Analgesia for Critically Ill Pediatric Burn Patients: The Current State of Practice
The objective of this study was to assess current practice patterns and attitudes toward pediatric sedation and analgesia in United States (US) burn centers for critically ill patients. Survey-based questionnaire was sent to 119 Directors at US burn centers that care for pediatric patients. Forty-one surveys (34%) were analyzed. 48.8% of responding centers mandate pediatric consultation for pediatric burn patients based on factors such as age and burn size. The most common sedation and analgesic agents used were midazolam, fentanyl, morphine, ketamine, and diphenhydramine. Written sedation policies exist at 63.4% of center...
Source: Journal of Burn Care and Research - May 1, 2015 Category: Rehabilitation Tags: Original Articles Source Type: research
Localized Erythema Multiforme-Like Contact Dermatitis From a Knee Brace
Abstract: A 47-year-old woman developed allergic contact dermatitis (ACD) to a knee brace after anterior cruciate ligament repair, manifesting as numerous erythema multiforme-like lesions. No previous cases of ACD to this Townsend Rebel knee brace, which is commonly worn postoperatively, have been reported. The patient was treated with triamcinolone ointment, cetirizine, and diphenhydramine. On follow-up, the lesions had resolved. We share this case to increase knowledge of this reaction pattern and encourage further similar reports to clarify the nature of the reaction. (Source: Clinical Journal of Sport Medicine)
Source: Clinical Journal of Sport Medicine - May 1, 2015 Category: Sports Medicine Tags: Case Report Source Type: research
Efficacy and tolerability studies evaluating a sleep aid and analgesic combination of naproxen sodium and diphenhydramine in the dental impaction pain model in subjects with induced transient insomnia
ConclusionsOnly the NS 440 mg/DPH 50 mg combination demonstrated improvement in both sleep latency vs. DPH 50 mg and sleep maintenance (WASO) vs. NS 440 mg. There were no serious or unexpected adverse events reported in either study. Clinical Trial Registration: NCT01280591 (study 1); NCT01495858 (study 2) (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - May 1, 2015 Category: Internal Medicine Authors: S. Cooper, I. Laurora, Y. Wang, P. Venkataraman, R. An, T. Roth Tags: Original Paper Source Type: research
Sex Differences In over-the-counter sleep aid use in older adults
Over-the-counter (OTC) sleep aids are widely self-administered and are generally safe, but their primary ingredients (diphenhydramine and doxylamine (DPH/DOX)) may pose risks, especially in older adults who may use these products outside of their label recommendations. This analysis characterizes the use of DPH/DOX for sleep disturbances by age and sex in older American adults. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: H.J. Gross, G. O’Neill, M. Toscani, J. Chapnick Source Type: research
Investigation of intercalation of diphenhydramine into the interlayer of smectite by XRD, FTIR, TG-DTG analyses and molecular simulation
In this study the intercalation of DPH in the interlayer of a Ca-smectite was characterized by X-ray diffraction, infra-red, and thermogravimetric analyses supported by molecular dynamic simulation. At the low (0.2–0.3 CEC) and high (0.6–0.7 CEC) adsorption levels, the intercalated DPH might take a horizontal monolayer or a bilayer configuration, resulting in a d001 expansion to 15 or 17 Å, respectively. As the amount of DPH intercalation increased, a gradual, yet systematic, dehydration due to removal of hydrated inorganic cation Ca2+ from the interlayer was observed. In addition, the intercalated DPH had a slightly ...
Source: Arabian Journal of Chemistry - April 25, 2015 Category: Chemistry Source Type: research
Intramolecular interactions contributing for the conformational preference of bioactive diphenhydramine: Manifestation of the gauche effect
Publication date: 5 August 2015 Source:Journal of Molecular Structure, Volume 1093 Author(s): Fátima M.P. de Rezende , Laize A.F. Andrade , Matheus P. Freitas Diphenhydramine is an antihistamine used to treat some symptoms of allergies and the common cold. It is usually marketed as the hydrochloride salt, and both the neutral and cation forms have the O–C–C–N fragment. The gauche effect is well known in fluorine-containing chains, because its main origin is hyperconjugative and the σ∗ C–F is a low-lying acceptor orbital, allowing electron delocalization in the conformation where F and an adjacent electronegat...
Source: Journal of Molecular Structure - April 22, 2015 Category: Molecular Biology Source Type: research
Enhanced Fenton-like degradation of pharmaceuticals over framework copper species in copper-doped mesoporous silica microspheres
Publication date: 15 August 2015 Source:Chemical Engineering Journal, Volume 274 Author(s): Lai Lyu , Lili Zhang , Chun Hu Copper-doped mesoporous silica microspheres (Cu-MSMs) with the coexistence of Cu(I) and Cu(II) were prepared using a hydrothermal process and characterized by several methods. The characterization studies suggested that 0.91wt% of the copper species could exist in the framework of the mesoporous silica microspheres by chemical binding of SiOCu; excess copper species were located in the extraframework sites, leading to more oxygen vacancies on the surface of the catalysts. The framework Cu of Cu-MSMs ...
Source: Chemical Engineering Journal - April 20, 2015 Category: Chemistry Source Type: research
Synthesis of pH-sensitive poly (N,N-dimethylaminoethyl methacrylate)-grafted halloysite nanotubes for adsorption and controlled release of DPH and DS drugs
Publication date: 18 May 2015 Source:Polymer, Volume 65 Author(s): Hamoon Hemmatpour , Vahid Haddadi-Asl , Hossein Roghani-Mamaqani Halloysite nanotube (HNT) was functionalized with (3-Aminopropyl)triethoxysilane (APTES), alpha-bromoisobutyryl bromide (BiBB), and poly (N,N-dimethylaminoethyl methacrylate) (PDMAEMA) chains. Successful grafting of PDMAEMA by SI-ATRP method was evaluated by XPS, FTIR, TEM, and TGA. Pore volume studies were accomplished by BET, and XRD was used to study crystalline structure of nanotubes. PDMAEMA coverage is formed on the outer and inner surface and also lumen of nanotubes. Sensitivity of PD...
Source: Polymer - April 17, 2015 Category: Chemistry Source Type: research
Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model.
Authors: Higuchi K, Kitamura A, Okura T, Deguchi Y Abstract Memantine is clinically used for the treatment of patients with Alzheimer's disease and is highly distributed to the brain. The aim of this study is to characterize memantine transport at the blood-brain barrier (BBB) using hCMEC/D3 cells, a human BBB model. The initial uptake velocity of memantine in hCMEC/D3 cells was concentration-dependent, and was reduced by metabolic inhibitors, but was independent of extracellular sodium ion and membrane potential. Intracellular alkalization and intracellular acidification markedly reduced and enhanced the uptake, r...
Source: Drug Metabolism and Pharmacokinetics - April 12, 2015 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
Effect of sodium chloride and myo-inositol on diphenhydramine hydrochloride drug in aqueous solution at different temperatures: Volumetric and acoustic approach
Publication date: August 2015 Source:The Journal of Chemical Thermodynamics, Volume 87 Author(s): Santosh P. Jengathe , Sudhakar S. Dhondge , Lalitmohan J. Paliwal , Vijay M. Tangde , Sudip Mondal Densities and speeds of sound of diphenhydramine hydrochloride (DPH) in aqueous solution and 0.06mol·kg−1 aqueous solutions of sodium chloride and myo-inositol (MI) have been measured at different temperatures, T =(288.15, 298.15 and 308.15)K over the concentration range (0.01 to 0.1)mol·kg−1. Density and speed of sound values were used to evaluate thermodynamic properties such as apparent molar volume (Vϕ ), isentropic ...
Source: The Journal of Chemical Thermodynamics - April 9, 2015 Category: Chemistry Source Type: research
Dosing, Side Effects, and Long-Term Outcomes for IVIg Use in Treatment of Neurological Conditions: Data from the Immunoglobulin Diagnosis, Evaluation, and key Learnings (IDEaL) Patient Registry (P6.036)
CONCLUSIONS: The data presented provides information on IVIg dosing for neurological subjects, and indicates that most patients did not report side effects from their IVIg therapy. The quality-of-life and outcomes data show improvements in overall physical function scores as well as in acute symptoms for patients receiving IVIg therapy. Study Supported by:Disclosure: Dr. Kearns has received personal compensation for activities with Coram Clinical Trials as an employee. Dr. Kristofek has received personal compensation for activities with Coram Clinical Trials as an employee. Dr. Bolgar has received personal compensation for...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kearns, S., Kristofek, L., Bolgar, B., Seidu, L. Tags: Neurotherapeutics Source Type: research