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Correction
Chan E, Jhanji V, Constantinou M, Amiel H, Snibson GR, Vajpayee RB. A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. Br J Ophthalmol 2014;98:166–71. A letter by Prakash and Jain was published in response to this article that includes a corrected figure from the original manuscript. Please see the letter by Chan E, Jhanji V, Constantinou M, et al. Br J Ophthalmol 2014;98:278–9 for the corrected figure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Tags: Corrections Source Type: research

Spectroscopic measurements in scleritis: Bluish-red or deep red?
Conclusions Reproducible measurements of the eye were made using an innovative, slit-lamp mountable spectrometer and its functionality demonstrated by differentiating the spectra from eyes with differing pathologies. While intending only to illustrate one potential application; for the cases examined, our results indicate that inflamed scleritic eyes exhibit a longer wavelength red light with no increase in shorter wavelength blue light. Thus our measurements would seem to confirm that the perceived redness of scleritis differs from other red eyes. However, it is a deeper darker red and not a bluish one as traditionally de...
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Bannister, N. P., Wakefield, M. J., Tatham, A., Bugby, S. L., Molyneux, P. M., Prydal, J. I. Tags: Sclera and apisclera Innovations Source Type: research

Corneal tolerance to micronised mineral pigments for keratopigmentation
Conclusions Micronised mineral pigments could be a valid alternative treatment for cosmetic keratopigmentation. The intralamellar keratopigmentation technique presented good cosmetic appearance without adverse effects in the eyes treated. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Amesty, M. A., Alio, J. L., Rodriguez, A. E. Tags: Original articles - Laboratory science Source Type: research

Inhibition by rebamipide of cytokine-induced or lipopolysaccharide-induced chemokine synthesis in human corneal fibroblasts
Conclusions Rebamipide inhibited the synthesis of chemokines by corneal fibroblasts in association with suppression of NFB signalling. Rebamipide may therefore prove effective for the treatment of corneal stromal inflammation associated with allergy or bacterial infection. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Fukuda, K., Ishida, W., Tanaka, H., Harada, Y., Fukushima, A. Tags: Original articles - Laboratory science Source Type: research

Serum-free medium and hydroxyethyl starch supports cell survival better than Minimal Essential Medium and dextran in organ-cultured mouse corneas
Conclusions Serum-free medium, Human Endothelial-SFM, promoted cell survival during corneal organ culture better than MEM+2% FCS. HES 130/0.4 appeared to be tolerated better by the cells than dextran T500. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Knels, L., Goetze, D., Engelmann, K., Valtink, M. Tags: Original articles - Laboratory science Source Type: research

Prognostic parameters in uveal melanoma and their association with BAP1 expression
Conclusions Loss of BAP1 expression associated well with all of the methods currently used for prognostication and was itself predictive of death due to metastasis in uveal melanoma after enucleation, thereby emphasising the importance of further research on the role of BAP1 in uveal melanoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: van Essen, T. H., van Pelt, S. I., Versluis, M., Bronkhorst, I. H., van Duinen, S. G., Marinkovic, M., Kroes, W. G., Ruivenkamp, C. A., Shukla, S., de Klein, A., Kilic, E., Harbour, J. W., Luyten, G. P., van der Velden, P. A., Verdijk, R. M., Jager, M. J. Tags: Eye (globe) Original articles - Laboratory science Source Type: research

High C4 gene copy numbers protects against Vogt-Koyanagi-Harada syndrome in Chinese Han
Conclusions Our findings indicate a decreased expression of serum C4 and a decreased frequency of high C4 gene copy number in patients with VKH. Trial registration number Chinese Clinical Trial Registration Number: ChiCTR-CCC-12002184. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Hou, S., Qi, J., Liao, D., Fang, J., Chen, L., Kijlstra, A., Yang, P. Tags: Original articles - Laboratory science Source Type: research

Risk characteristics of the combined geographic atrophy and choroidal neovascularisation phenotype in age-related macular degeneration
Conclusions The combined GA/CNV phenotype has similar epidemiologic, clinical, and genetic features as GA and CNV, but occurs at an older age and is more associated with advanced AMD in the fellow eye, suggesting that all these phenotypes are part of the same spectrum of disease and that the combined phenotype represents an even more advanced form of AMD than either GA or CNV. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Saade, C., Ganti, B., Marmor, M., Freund, K. B., Smith, R. T. Tags: Choroid, Retina, Epidemiology Original articles - Clinical science Source Type: research

Genetic analysis of strictly defined Leber congenital amaurosis with (and without) neurodevelopmental delay
Conclusions Neurodevelopmental delay is a potential feature of strictly defined LCA, documented in our series for some children with homozygous RPGRIP1 and GUCY2D mutations. Strictly defining LCA can limit genetic heterogeneity. On the Arabian Peninsula, the phenotype is frequently from recessive RPGRIP1 mutations, most of which are a founder RPGRIP1 deletion. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Khan, A. O., Al-Mesfer, S., Al-Turkmani, S., Bergmann, C., Bolz, H. J. Tags: Vision, Neurology Original articles - Clinical science Source Type: research

Novel ADAM9 homozygous mutation in a consanguineous Egyptian family with severe cone-rod dystrophy and cataract
Conclusions and relevance We identified a novel autosomal recessive ADAM9 mutation causing arCRD in a consanguineous Egyptian family. The percentage of arCRD cases caused by mutation in ADAM9 remains to be determined. Few families are reported in the literature to date; hence extensive clinical descriptions of families with ADAM9 mutations are of significant importance. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: El-Haig, W. M., Jakobsson, C., Favez, T., Schorderet, D. F., Abouzeid, H. Tags: Public health, Angle, Eye (globe), Intraocular pressure, Lens and zonules, Retina, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Prevalence and risk factors of dry eye disease in a British female cohort
Conclusions DED is common and increases with age within this cohort of female twins. We confirmed established risk factors for the first time in a British population, and found important risk factors that might relate to an underlying aetiology involving chronic pain predisposition or somatisation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Vehof, J., Kozareva, D., Hysi, P. G., Hammond, C. J. Tags: Lens and zonules, Press releases, Neurology Original articles - Clinical science Source Type: research

Randomised masked clinical trial of the MGDRx eyebag for the treatment of meibomian gland dysfunction-related evaporative dry eye
Conclusions The MGDRx EyeBag is a safe and effective device for the treatment of MGD-related evaporative dry eye. Subjective benefit lasts at least 6 months, aided by occasional retreatment. Trial registration number NCT01870180. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Bilkhu, P. S., Naroo, S. A., Wolffsohn, J. S. Tags: Open access Original articles - Clinical science Source Type: research

Long-term outcomes of optical coherence tomography-guided transepithelial phototherapeutic keratectomy for the treatment of anterior corneal scarring
Conclusions The OCT-guided transepithelial PTK technique described in this study can deliver positive long-term results and predictable refractive outcomes in the treatment of anterior corneal scarring. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Rush, S. W., Matulich, J., Rush, R. B. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Estimation of ocular volume from axial length
Conclusion Clinically useful estimations of ocular volume can be obtained from measurement of AL and CR. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Nagra, M., Gilmartin, B., Logan, N. S. Tags: Original articles - Clinical science Source Type: research

The tarsal belt procedure for the correction of ectropion: description and outcome in 42 cases
Conclusions The tarsal belt seems to be effective to correct the horizontal and vertical instability of the lid. The suture supports the lower eyelid along the entire tarsal plate length and corrects the outward buckling of the tarsal plate. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Pascali, M., Corsi, A., Brinci, L., Corsi, I., Cervelli, V. Tags: Eye Lids Original articles - Clinical science Source Type: research

Outcomes of posterior-approach 'levatorpexy' in congenital ptosis repair
Conclusions Posterior approach levatorpexy appears to be a safe and effective procedure for correction of congenital ptosis particularly with moderate or better levator function. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: AL-Abbadi, Z., Sagili, S., Malhotra, R. Tags: Original articles - Clinical science Source Type: research

Number of excisions required to obtain clear surgical margins and prognostic value of AJCC T category for patients with eyelid melanoma
Conclusions More than a third of patients with eyelid melanoma required more than 1 excision to achieve clear margins, supporting delayed reconstruction for eyelid melanoma. Nodal metastasis at presentation was significantly correlated with AJCC T category and time to progression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Yin, V. T., Warneke, C. L., Merritt, H. A., Esmaeli, B. Tags: Original articles - Clinical science Source Type: research

Long-term outcomes in primary powered endoscopic dacryocystorhinostomy
Conclusions Powered endoscopic DCR is a safe procedure and offers excellent long-term results. Adjunctive endonasal procedures should be performed where indicated. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Ali, M. J., Psaltis, A. J., Bassiouni, A., Wormald, P. J. Tags: Ophthalmologic surgical procedures, Lacrimal gland, Tears Original articles - Clinical science Source Type: research

Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction
Conclusions Obstructive sialadenitis of transplanted SMGs is a chronic inflammation secondary to ductal obstruction, which leads to insufficient ocular lubrication and potential treatment failure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Su, J.-Z., Yang, N.-Y., Liu, X.-J., Cai, Z.-G., Lv, L., Zhang, L., Wu, L.-L., Liu, D.-G., Ren, W.-G., Gao, Y., Yu, G.-Y. Tags: Conjunctiva, Cornea, Lacrimal gland, Ocular surface, Tears Original articles - Clinical science Source Type: research

Retcam fluorescein angiography findings in eyes with advanced retinoblastoma
Conclusions Advanced intraocular retinoblastoma is associated with multiple retinal vascular abnormalities on Retcam FA. These findings may be helpful in defining the extent of disease and distinguishing this tumour from other paediatric ocular conditions. Key clinical findings were subclinical iris neovascularisation, a variety of small vessel changes, intrinsic tumour vessels and retinal venous leakage. Retcam FA was not found to be clinically useful after 3 min. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Kim, J. W., Ngai, L. K., Sadda, S., Murakami, Y., Lee, D. K., Murphree, A. L. Tags: Original articles - Clinical science Source Type: research

Metabolic activity of primary uveal melanoma on PET/CT scan and its relationship with monosomy 3 and other prognostic factors
Conclusions Metabolic activity of uveal melanoma on PET/CT scan is positively correlated with monosomy 3, increasing tumour size and TNM prognostic groups. No association with chromosome 8 gain or histopathology cell type was noted. SUVmax >4 is a relative but not an absolute indicator of monosomy 3 status. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Papastefanou, V. P., Islam, S., Szyszko, T., Grantham, M., Sagoo, M. S., Cohen, V. M. L. Tags: Eye (globe), Open access, Epidemiology Original articles - Clinical science Source Type: research

Comparison of uveal melanoma cytopathologic sample retrieval in trans-scleral versus vitrectomy-assisted transvitreal fine needle aspiration biopsy
Conclusions Trans-scleral and vitrectomy-assisted transvitreal fine needle aspiration biopsy resulted in similar tissue yield for cytopathologic analysis. As molecular prognostication becomes the standard of care for obtaining patient information and directing clinical management, further investigation of biopsy techniques is warranted. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Chang, M. Y., McCannel, T. A. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Discordance of two interferon-{gamma} release assays and tuberculin skin test in patients with uveitis
Conclusions Discordance of IGRA and TST results is common and requires further study. In our study in patients with uveitis, we found that ethnicity, age, and type of uveitis were some significant factors associated with TST/IGRA discordance, which may need to be taken into consideration when interpreting these results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Ang, M., Kiew, S. Y., Wong, W. L., Chee, S.-P. Tags: Choroid Original articles - Clinical science Source Type: research

Three-year visual outcome of photodynamic therapy plus intravitreal bevacizumab with or without subtenon triamcinolone acetonide injections for polypoidal choroidal vasculopathy
Conclusions Initial therapy consisting of a single session of PDT combined with IVB and STTA improves vision in treatment-naive subfoveal PCV. Compared with double therapy, this triple therapy may be more effective for PCV. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Sakai, T., Ohkuma, Y., Kohno, H., Hayashi, T., Watanabe, A., Tsuneoka, H. Tags: Choroid Original articles - Clinical science Source Type: research

Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD
Conclusions There are notable differences in systemic pharmacokinetics and pharmacodynamics among anti-VEGF treatments after intravitreal administration. All three agents rapidly moved into the bloodstream, but ranibizumab very quickly cleared, whereas bevacizumab and aflibercept demonstrated greater systemic exposure and produced a marked reduction in plasma free VEGF. Trial registration number NCT02118831. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Avery, R. L., Castellarin, A. A., Steinle, N. C., Dhoot, D. S., Pieramici, D. J., See, R., Couvillion, S., Nasir, M. A., Rabena, M. D., Le, K., Maia, M., Visich, J. E. Tags: Retina, Open access Original articles - Clinical science Source Type: research

Intraretinal cysts are the most relevant prognostic biomarker in neovascular age-related macular degeneration independent of the therapeutic strategy
Conclusions Combination and monotherapy showed a distinct response pattern for morphological parameters in nAMD. IRC was the only relevant prognostic parameter for functional outcome. Trial registration number NCT00433017. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Ritter, M., Simader, C., Bolz, M., Deak, G. G., Mayr-Sponer, U., Sayegh, R., Kundi, M., Schmidt-Erfurth, U. M. Tags: Retina Original articles - Clinical science Source Type: research

The role of social deprivation in severe neovascular age-related macular degeneration
Conclusions The late presentation and under-representation of patients with greater social deprivation is a serious concern. Our study strongly suggests that this vulnerable group is encountering barriers in accessing treatment in nAMD, and that these occur prior to entry into the Hospital Eye Service. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Sharma, H. E., Mathewson, P. A., Lane, M., Shah, P., Glover, N., Palmer, H., Haque, M. S., Denniston, A. K., Tsaloumas, M. D. Tags: Retina Original articles - Clinical science Source Type: research

The correlation between retinal sensitivity assessed by microperimetry and contrast sensitivity in diabetic macular oedema
Conclusions CS and RS showed moderately significant correlations in CSME. However, neither CS nor RS was correlated with RT in patients with CSME. It could be that CS and MP are complementary to each other and are useful tools in the evaluation of functional vision. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Kim, Y. H., Yun, C., Kim, J. T., Kim, S.-W., Oh, J., Huh, K. Tags: Retina Original articles - Clinical science Source Type: research

SAVE: a grading protocol for clinically significant diabetic macular oedema based on optical coherence tomography and fluorescein angiography
Conclusions The ‘SAVE’ grading protocol of CSME integrates information from two imaging techniques, OCT and FA. Its clinical approach allows examiners to define and further categorise clinical characteristics to find tailored therapeutic strategies. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Bolz, M., Lammer, J., Deak, G., Pollreisz, A., Mitsch, C., Scholda, C., Kundi, M., Schmidt-Erfurth, U., for the Diabetic Retinopathy Research Group Vienna Tags: Original articles - Clinical science Source Type: research

Teleglaucoma: ready to go?
Telemedicine technologies and services allow today's ophthalmic clinicians to remotely diagnose, manage and monitor several ophthalmic conditions from a distance. But is this the case for glaucomas? There has been a proliferation of telemedicine friendly devices in recent years that improves the capabilities of the clinician in managing glaucomas. The existing instruments still need to align themselves with accepted industry standards. There are successful programmes running in several areas of the world. The safety and efficacy of these programmes needs further exploration. The inability of a single device or test to diag...
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Strouthidis, N. G., Chandrasekharan, G., Diamond, J. P., Murdoch, I. E. Tags: Public health, Angle, Intraocular pressure, Open access, Glaucoma Review Source Type: research

Highlights from this issue
In the United Kingdom, a national diabetic retinopathy screening service has pioneered the use of remote monitoring of disease at a population level. Glaucoma has persistently frustrated clinicians and those who have tried to apply a similar model of diagnosis and monitoring. In this month's issue Strouthidis et al1 discuss the barriers to remote diagnosis of glaucoma and review the future prospects for telemedicine in this area. There are a number of grading systems of clinically significant diabetic macular oedema. Bolz et al2 describe a new grading protocol based on a combination of OCT and fluorescein angiographic find...
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

First clinical results on the feasibility, quality and reproducibility of aberrometry-based intraoperative refraction during cataract surgery
Conclusions This is the first report addressing quality and reproducibility of WA in a large sample. IWA refraction in aphakia, for instance, appears to be reliable once stable and pressurised anterior chamber conditions are achieved. More efforts are required to improve the precision and quality of measurements before IWA can be used to guide the surgical refractive plan in cataract surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Huelle, J. O., Katz, T., Druchkiv, V., Pahlitzsch, M., Steinberg, J., Richard, G., Linke, S. J. Tags: Lens and zonules Original articles - Clinical science Source Type: research

Correction
Pradeep A, Proudlock FA, Awan M, Bush G, Collier J, Gottlob I. An educational intervention to improve adherence to high-dosage patching regimen for amblyopia: a randomised controlled trial. Br J Ophthalmol 2014;98:865–870. The authors of this article should have acknowledged Huib Simonsz and colleagues from Rotterdam who designed and manufactured an occlusion-dose monitor (ODM) prior to the monitor discussed in this study. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Tags: Corrections Source Type: research

Lamina cribrosa displacement after optic nerve sheath fenestration in idiopathic intracranial hypertension: a new tool for monitoring changes in intracranial pressure?
Introduction Imaging in patients with idiopathic intracranial hypertension (IIH) is by definition normal but MRI may show dilatation of the subarachnoid space (SAS) around the optic nerve and a secondary flattening of the posterior sclera.1 Because of the existence of a trans-lamina cribrosa (LC) gradient, in patients with IIH the disc surface and thus the LC should be anteriorly displaced secondary to the raised intracranial pressure (ICP). In patients with glaucoma, an anterior displacement of the LC after lowering intraocular pressure (IOP) using spectral domain optical coherence tomography (SD-OCT) has been recently de...
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Perez-Lopez, M., Ting, D. S. J., Clarke, L. Tags: Letters Source Type: research

Masquerade ectasia
A 41-year-old otherwise healthy Pakistani male presented to our Cornea Clinic. He gave a history of bilateral, gradual, childhood onset myopia for which he used soft contact lenses (CL) daily for 20 years until 2009. Then, due to increasing astigmatism, he switched to rigid gas permeable (RGP) CLs. Because he experienced increasing discomfort after a year of using RGPs, his CL specialist tried several other CL options over the following 2 years, including mini-scleral and ‘piggy back’ lenses with little success. On examination, his right eye Log MAR corrected visual acuity with glasses was 0.58, best ...
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Dhillon, V. K., Elalfy, M. S., Albert, R., Shah, P. A., Mahmood, K., Dua, H. S. Tags: Cornea, Ocular surface, Optic nerve, Optics and refraction Education Source Type: research

Modified big-bubble deep anterior lamellar keratoplasty using peripheral air injection
Conclusions Air injection peripheral to the trephination site is a reproducible modification to the standard technique which can decrease the risk of DM perforation during air injection. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Feizi, S., Faramarzi, A., Javadi, M. A., Jafarinasab, M. R. Tags: Ophthalmologic surgical procedures Original articles - Laboratory science Source Type: research

CFI-rs7356506 is a genetic protective factor for acute anterior uveitis in Chinese patients
Conclusions This study has revealed a significant association between AAU and CFI-rs7356506, suggesting that CFI is involved in the pathogenesis of AAU, and that its influence on AAU may differ depending on gender and HLA-B27 status. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Wang, Y., Huang, X.-F., Yang, M.-M., Cai, W.-J., Zheng, M.-Q., Mao, G., Pang, C.-P., Jin, Z.-B. Tags: Choroid, Epidemiology Original articles - Laboratory science Source Type: research

Visualisation of contrast-enhanced intraoperative optical coherence tomography with indocyanine green
In this report, we describe the OCT features and contrast enhancement noted with indocyanine green using iOCT in human subjects as well as an ex vivo analysis in porcine eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Ehlers, J. P., McNutt, S., Dar, S., Tao, Y. K., Srivastava, S. K. Tags: Innovations Source Type: research

A new method using xenogeneicacellular dermal matrix in the reconstruction of lacrimal drainage
Conclusions The newly reconstructed lacrimal duct, formed by the shift of autogenous conjunctival petal and the attachment of acellular dermal matrix, was successful in all five cases and suggests a new solution for the complex lacrimal duct lesion and congenital anomalies of the lacrimal duct. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Chen, L., Gong, B., Wu, Z., Jetton, J., Chen, R., Qu, C. Tags: Lacrimal gland, Tears, Open access Original articles - Clinical science Source Type: research

Comparison of surgical outcomes between simple posterior layer advancement of lower eyelid retractors and combination with a lateral tarsal strip procedure for involutional entropion in a Japanese population
Conclusions The combination surgery in Group C and simple posterior layer advancement of the LER in Group B provided complete surgical success. The present study suggests the importance of preoperative evaluation of horizontal laxity, allowing surgeons to perform the least amount of surgery to achieve success. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Lee, H., Takahashi, Y., Ichinose, A., Kakizaki, H. Tags: Eye Lids Original articles - Clinical science Source Type: research

Orbital cellulitis in Scotland: current incidence, aetiology, management and outcomes
This study was a 1-year prospective observational study using the Scottish Ophthalmic Surveillance Unit reporting system among Scottish ophthalmologists. Results The response rate from ophthalmologists was 66.4%. There were 15 children and 5 adults reported giving an incidence of 1.6 per 100 000 and 0.1 per 100 000 in children and adults, respectively. 47% of children had a preceding upper respiratory tract infection with 87% having radiological evidence of sinus disease. Within the adult group, there was preceding immunosuppression and trauma. Streptococcus (66%) and Haemophilus (46%) species were the most comm...
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Murphy, C., Livingstone, I., Foot, B., Murgatroyd, H., MacEwen, C. J. Tags: Paediatrics, Epidemiology Original articles - Clinical science Source Type: research

Efficacy of diagnostic monocular occlusion in revealing the maximum angle of exodeviation
Conclusions Diagnostic monocular occlusion could be useful in patients with DE-type or CI-type exotropia and with hyperopia. In other cases, however, it has a limited role in determining the maximum angle of exodeviation compared with multiple examinations. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Han, J. M., Yang, H. K., Hwang, J.-M. Tags: Public health, Muscles, Optic nerve, Neurology, Optics and refraction Original articles - Clinical science Source Type: research

Weight at first detection of retinopathy of prematurity predicts disease severity
Conclusions Low weight and low WSDS at first ROP detection can be useful predictors for ROP warranting treatment. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Lundgren, P., Wilde, A., Lofqvist, C., Smith, L. E. H., Hard, A.-L., Hellstrom, A. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Validity and reliability of head posture measurement using Microsoft Kinect
Conclusions The KHT showed good agreement with the CROM and relatively favourable test–retest reliability. Considering its high performance, convenience and low cost, KHT could be clinically used as a head posture-measuring system. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Oh, B.-L., Kim, J., Kim, J., Hwang, J.-M., Lee, J. Tags: Original articles - Clinical science Source Type: research

Disc haemorrhage is associated with the fast component, but not the slow component, of visual field decay rate in glaucoma
Conclusions The presence of DH is associated with a greater fast component rate of VF decay. The identification and monitoring of the fast component of VF decay may prove useful in the identification and management of glaucoma patients at high risk of progression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Kim, J. M., Kyung, H., Azarbod, P., Lee, J. M., Caprioli, J. Tags: Angle, Intraocular pressure, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow
Discussion OAG patients of AD may have a stronger vascular component to their glaucoma pathophysiology than patients of ED. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Kanakamedala, P., Harris, A., Siesky, B., Tyring, A., Muchnik, M., Eckert, G., Abrams Tobe, L. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Combined endoscopic vitrectomy with pars plana tube shunt procedure
Conclusions Endoscopic vitrectomy with pars plana glaucoma tube shunt implantation may be considered in the management of uncontrolled IOP in patients with media opacity. Achieving IOP control prior to attempted anterior segment reconstruction in these severely diseased eyes may increase the success rate and decrease the complexity of subsequent anterior reconstruction procedures. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Shaikh, A. H., Khatana, A. K., Zink, J. M., Miller, D. M., Petersen, M. R., Correa, Z. M., Riemann, C. D. Tags: Ophthalmologic surgical procedures, Angle, Eye (globe), Intraocular pressure, Iris, Glaucoma Original articles - Clinical science Source Type: research

Effect of pegaptanib sodium 0.3 mg intravitreal injections (Macugen) in intraocular pressure: posthoc analysis from V.I.S.I.O.N. study
Conclusions In V.I.S.I.O.N., after 2 years, there was no evidence of sustained IOP elevation associated with pegaptanib 0.3 mg use. Trial registration number NCT00321997. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Boyer, D. S., Goldbaum, M., Leys, A. M., Starita, C., for the V.I.S.I.O.N. Study Group, Blumenkranz, Buyse, Goldberg, Gragoudas, Miller, Schwartz, Singerman, Yannuzzi, Adamis, Guyer, O'Shaughnessy, Buyse, de Gronckel, Fesneau, Quinaux, Tremolet, Wang, Bra Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Small incision iris tumour biopsy using a cavernous sampling forceps
Conclusions Iris tumour biopsies can be successfully approached using a cavernous 23G intraocular forceps with a low risk for procedure-related complications. The conical interior design allows for removal of whole tissue pieces with minimal manipulative artefacts. An optional bimanual access through a second corneal incision and use of a 23G scissors provides better efficacy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Chronopoulos, A., Kilic, E., Joussen, A. M., Lipski, A. Tags: Eye (globe), Pupil, Neurology Original articles - Clinical science Source Type: research

Progression of foveola-on rhegmatogenous retinal detachment
Conclusions The risk of progression of a foveola-on RRD to affect the fovea is small the first night of admission (1%). The amount of time surgery is delayed was found as significant risk factor for progression towards foveola. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Hajari, J. N., Kyhnel, A., Bech-Azeddine, J., la Cour, M., Kiilgaard, J. F. Tags: Retina Original articles - Clinical science Source Type: research