British Journal of Ophthalmology British Journal of Ophthalmology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the latest items in this publication.

High-irradiance CXL combined with myopic LASIK: flap and residual stroma biomechanical properties studied ex-vivo
Conclusions LASIK+CXL appears to provide significant increase in underlying corneal stromal rigidity, up to +130%. Additionally, there is significant relevant enzymatic digestion resistance confirmatory to the above. LASIK flaps appear unaffected biomechanically by the LASIK+CXL procedure, suggesting effective CXL just under the flap. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Kanellopoulos, A. J., Asimellis, G., Salvador-Culla, B., Chodosh, J., Ciolino, J. B. Tags: Ophthalmologic surgical procedures Original articles - Laboratory science Source Type: research

Compatibility of recombinant tissue plasminogen activator (rtPA) and aflibercept or ranibizumab coapplied for neovascular age-related macular degeneration with submacular haemorrhage
Conclusions Ranibizumab is not cleaved or functionally compromised by rtPA or plasmin. Aflibercept is cleaved and its VEGF-binding ability is reduced when coapplied with plasmin. In clinical practice, rtPA and ranibizumab can be coapplied as a treatment for neovascular age-related macular degeneration with submacular haemorrhage while the antiangiogenic activity of aflibercept may be compromised when coapplied with rtPA in the presence of plasmin. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Klettner, A., Groteluschen, S., Treumer, F., Roider, J., Hillenkamp, J. Tags: Retina, Editor's choice Original articles - Laboratory science Source Type: research

Outcomes of epiretinal membrane surgery in highly myopic eyes: a case-control study
Conclusions ERM surgery resulted in similar anatomical and functional outcomes in both groups. Longer axial length does not seem to affect visual improvement and the complication rate. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Conart, J.-B., Favel, C., Selton, J., Hubert, I., Cloche, V., Trechot, F., Berrod, J.-P. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Retinal nerve fibre layer thickness measurements after successful retinal detachment repair with silicone oil endotamponade
Conclusions In patients with silicone oil tamponade, peripapillary RNFL was significantly thicker in comparison with fellow unoperated eyes over a 6-month period. Trial registration number NCT 01255306. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Zoric Geber, M., Bencic, G., Vatavuk, Z., Ivekovic, R., Friberg, T. R. Tags: Ophthalmologic surgical procedures, Retina Original articles - Clinical science Source Type: research

A prospective pilot study of intravitreal aflibercept for the treatment of chronic central serous chorioretinopathy: the CONTAIN study
Conclusions Intravitreal aflibercept was well tolerated over a 6-month treatment course for chronic CSCR. No change was observed in visual acuity metrics. Anatomic trends may suggest some morphological activity, but larger controlled trials are needed. Trial registration number NCT01710332 (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Pitcher, J. D., Witkin, A. J., DeCroos, F. C., Ho, A. C. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

MultiColor imaging in the evaluation of geographic atrophy due to age-related macular degeneration
Conclusions We demonstrated that several different imaging modalities currently available in clinical practice are reliable for evaluating GA due to AMD. MultiColor is an excellent tool for the measurement of GA area and width, and for the detection of foveal sparing. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Moussa, N. B., Georges, A., Capuano, V., Merle, B., Souied, E. H., Querques, G. Tags: Retina Original articles - Clinical science Source Type: research

Relationship of systemic endothelial function and peripheral arterial stiffness with diabetic retinopathy
Conclusions Subjects with more severe DR have larger peripheral reactive hyperaemic responses and greater peripheral vascular stiffness. These findings support the link between the microvascular changes of diabetes and macrovascular disease. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Lim, L. S., Ling, L. H., Cheung, C. M. G., Ong, P. G., Gong, L., Tai, E. S., Mathur, R., Wong, D., Foulds, W., Wong, T. Y. Tags: Public health, Retina Original articles - Clinical science Source Type: research

Rapid assessment of avoidable blindness and diabetic retinopathy in Republic of Moldova
Conclusions The RAAB+DR survey in the Republic of Moldova established that untreated cataract is the major cause of avoidable blindness in rural areas. This needs to be tackled by expanding the geographical coverage of cataract surgical services. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Zatic, T., Bendelic, E., Paduca, A., Rabiu, M., Corduneanu, A., Garaba, A., Novac, V., Curca, C., Sorbala, I., Chiaburu, A., Verega, F., Andronic, V., Guzun, I., Capatina, O., Zama-Mardari, I. Tags: Angle, Intraocular pressure, Lens and zonules, Retina, Vision, Neurology, Glaucoma Original articles - Clinical science Source Type: research

Telemedicine for detecting diabetic retinopathy: a systematic review and meta-analysis
Conclusions The diagnostic accuracy of telemedicine using digital imaging in DR is overall high. It can be used widely for DR screening. Telemedicine based on the digital imaging technique that combines mydriasis with a wide angle field (100–200°) is the best choice in detecting the absence of DR and the presence of mild NPDR. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Shi, L., Wu, H., Dong, J., Jiang, K., Lu, X., Shi, J. Tags: Public health, Retina, Pupil, Open access, Epidemiology Original articles - Clinical science Source Type: research

Prognostic factors of 2-year outcomes of ranibizumab therapy for polypoidal choroidal vasculopathy
Conclusions Patient age, baseline VA and clusters of grape-like polypoidal lesions predicted VA outcomes 2 years after treatment with IVR for PCV. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Hikichi, T., Kitamei, H., Shioya, S. Tags: Choroid Original articles - Clinical science Source Type: research

Proton beam radiotherapy of diffuse iris melanoma in 54 patients
Conclusions As an alternative to enucleation, whole anterior segment fractionated proton beam radiotherapy offered excellent local tumour control in diffuse iris melanoma. Given the limited alternatives, the rate of complications appears acceptable and visual function could be preserved in the majority of the patients during follow-up. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Willerding, G. D., Cordini, D., Hackl, C., Karle, B., Lakotka, N., Foerster, M. H., Bechrakis, N. N., Heufelder, J., Moser, L., Joussen, A. M. Tags: Angle, Intraocular pressure, Lens and zonules, Glaucoma Original articles - Clinical science Source Type: research

Incidence and treatment of retinopathy of prematurity in England between 1990 and 2011: database study
Conclusions Increased neonatal survival, improved awareness of ROP and dissemination of guidance on screening and treatment of ROP will all have contributed to the substantial rise in recorded incidence of ROP between 1990 and 2011. Retinal ablation is now almost always performed using laser treatment rather than cryotherapy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Painter, S. L., Wilkinson, A. R., Desai, P., Goldacre, M. J., Patel, C. K. Tags: Paediatrics, Public health, Retina, Epidemiology Original articles - Clinical science Source Type: research

Visual impairment due to retinopathy of prematurity (ROP) in New Zealand: a 22-year review
Conclusions There has been a reduction in the incidence of infants with significant visual impairment from ROP over time in New Zealand, likely due to progress in clinical management of ROP. Our study suggests the current ROP screening criteria of <31 weeks' gestation or <1250 g are of sufficient breadth. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Tan, Z., Chong, C., Darlow, B., Dai, S. Tags: Retina, Vision, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Quantitative comparison of macular segmentation performance using identical retinal regions across multiple spectral-domain optical coherence tomography instruments
Conclusions By comparison of identical regions, substantial differences were detected between the tested OCT devices regarding technical accuracy and clinical impact. Spectralis showed lowest error incidence but highest error impact. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Waldstein, S. M., Gerendas, B. S., Montuoro, A., Simader, C., Schmidt-Erfurth, U. Tags: Original articles - Clinical science Source Type: research

Morphologic and vasculature features of the choroid and associated choroid-retinal thickness alterations in neurofibromatosis type 1
Conclusions In NF1, there are dome-shaped and placcoid choroidal nodules which alter choroidal morphology and thickness. There is reduction in mean choroid thickness with generalised thinning of the neuroepithelium, photoreceptors together with RPE and ONL in NF1 patients. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Abdolrahimzadeh, S., Felli, L., Plateroti, R., Plateroti, A. M., Giustini, S., Calvieri, S., Recupero, S. M. Tags: Neurology Original articles - Clinical science Source Type: research

Influence of graft size on graft survival following Descemet stripping automated endothelial keratoplasty
Conclusions Larger grafts occupy a smaller chord length in the eye than the trephine size and are expected to provide 10%–20% more endothelial cells. Increased graft size and donor ECD is significantly associated with a reduced graft failure rate. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Romano, V., Tey, A., Hill, N. M. E., Ahmad, S., Britten, C., Batterbury, M., Willoughby, C., Kaye, S. B. Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Modified lamellar keratoplasty and immunosuppressive therapy guided by in vivo confocal microscopy for perforated Mooren's ulcer
Conclusions Modified LK, combined with immunosuppressive therapy, can effectively treat perforated Mooren's ulcer, with few complications. The use of corticosteroids and immunosuppressants guided by IVCM may reduce the disease recurrence. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Liu, J., Shi, W., Li, S., Gao, H., Wang, T. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Efficacy and safety of pre-Descemet's membrane sutures for the management of acute corneal hydrops in keratoconus
Conclusions Our results suggest that intrastromal pre-DM sutures and intracameral air injection could promptly restore imperviousness of posterior stroma. This technique seems to be a safe and useful procedure to shorten acute corneal hydrops. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Yahia Cherif, H., Gueudry, J., Afriat, M., Delcampe, A., Attal, P., Gross, H., Muraine, M. Tags: Cornea, Ocular surface Original articles - Clinical science Source Type: research

Spontaneous long-term course of persistent peripheral graft detachments after Descemet's membrane endothelial keratoplasty
Conclusions Persistent peripheral graft detachments after DMEK occurred in 10% of patients and had two distinct OCT-phenotypes. Peripheral rolls did not change during the first 12 months, postoperatively. By contrast, peripheral laminar detachments attached spontaneously even months after surgery. Corneal thickness reduction was only observed above peripheral laminar detachment, but not above peripheral rolls. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Bucher, F., Hos, D., Muller-Schwefe, S., Steven, P., Cursiefen, C., Heindl, L. M. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Migration study of lens opacities in Bangladeshi adults in London and Bangladesh: a pilot study
Discussion The study highlights the challenges of migration studies, and of studies involving ethnic minorities. Preliminary findings suggest that migration to the UK is protective for LO despite a significantly higher rate of diabetes in the UK. A larger study is warranted based on these preliminary findings. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Finger, R. P., Sivasubramaniam, S., Morjaria, P., Bansal, A., Muhit, M., Kinra, S., Gilbert, C. E. Tags: Lens and zonules Original articles - Clinical science Source Type: research

Ocular alignment after bilateral lateral rectus recession in exotropic children with cerebral palsy
Conclusions CP patients with exotropia showed successful ocular alignment comparable to that of controls after BLR recession of at least 2 years. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Han, S. Y., Han, J., Han, S.-H., Lee, J. B., Rhiu, S. Tags: Paediatrics, Muscles, Neurology Original articles - Clinical science Source Type: research

Normative data for three tests of visuocognitive function in primary school children: cross-sectional study
Conclusions These different aspects of children’s visuocognitive performance were testable in a field setting. The data provide a benchmark by which to judge performance of children with neurodevelopmental problems and may be useful in assessment with a view to providing effective supportive strategies for children whose visuocognitive skills are lower than the expectation for their age. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Williams, C., Gilchrist, I. D., Fraser, S., McCarthy, H., Parker, J., Warnes, P., Young, J., Hyvarinen, L. Tags: Open access, Epidemiology Original articles - Clinical science Source Type: research

Significance of corneal biomechanical properties in patients with progressive normal-tension glaucoma
Conclusions Corneal biomechanical properties are correlated and associated with the progression of visual field damage in NTG patients. These findings suggest that CH can be used as one of the prognostic factors for progression, independent of corneal thickness or intraocular pressure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Park, J. H., Jun, R. M., Choi, K.-R. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

A randomised, controlled comparison of latanoprostene bunod and latanoprost 0.005% in the treatment of ocular hypertension and open angle glaucoma: the VOYAGER study
Conclusions LBN 0.024% dosed once daily was the lower of the two most effective concentrations evaluated, with significantly greater IOP lowering and comparable side effects relative to latanoprost 0.005%. LBN dosed once daily for 28 days was well tolerated. Clinical trial number NCT01223378. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Weinreb, R. N., Ong, T., Scassellati Sforzolini, B., Vittitow, J. L., Singh, K., Kaufman, P. L., Ackerman, Branch, Cottingham, Day, Depenbusch, El-Hazari, Firozvi, Jorizzo, Ou, Peace, Rotberg, Schenker, Smith, Tyson, Zaman, Madzharova, Toshev, Vassilveva, Tags: Angle, Intraocular pressure, Open access, Glaucoma Original articles - Clinical science Source Type: research

Retinal nerve fibre layer thickness floor and corresponding functional loss in glaucoma
Conclusions Global RNFL thinning reaches the floor at a smaller VF loss level with Spectralis than with RTVue. The nasal and temporal quadrants retain thinner residual layers than superior and inferior quadrant RNFL. Measuring RNFL below their minimums will not yield useful clinical information. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Mwanza, J.-C., Budenz, D. L., Warren, J. L., Webel, A. D., Reynolds, C. E., Barbosa, D. T., Lin, S. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Causes and emerging trends of childhood blindness: findings from schools for the blind in Southeast Nigeria
Conclusions The results from this study show a statistically significant decrease in avoidable blindness in children ≤15 years old. Corneal blindness appears to be decreasing but cortical visual impairment seems to be emerging in the younger age group. Appropriate strategies for the prevention of avoidable childhood blindness in Nigeria need to be developed and implemented. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Aghaji, A., Okoye, O., Bowman, R. Tags: Vision, Neurology Global issues Source Type: research

Dexamethasone intravitreal implant as adjunct therapy for patients with wet age-related macular degeneration with incomplete response to ranibizumab
Conclusions DXI appears to be effective in vision stabilisation, decreasing IRF/SRF and improvement of CRT in eyes with refractory wet AMD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Calvo, P., Ferreras, A., Al Adel, F., Wang, Y., Brent, M. H. Tags: Lens and zonules, Retina Innovations Source Type: research

Current knowledge on reticular pseudodrusen in age-related macular degeneration
Drusen are focal deposits of extracellular material located between the retinal pigment epithelium (RPE) and Bruch's membrane and represent the major phenotypic characteristic of age-related macular degeneration (AMD). Due to evolving imaging techniques and recent histological studies, reticular pseudodrusen (RPD) have received increasing attention and have been recently identified as an additional phenotypic entity in AMD. In contrast to conventional drusen, RPD proved to be located internal to the RPE. In the past few years, numerous studies collected new findings on RPD related to their pathogenesis, imaging properties ...
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Alten, F., Eter, N. Tags: Retina Review Source Type: research

Highlights from this issue
Budenz et al (see page 732) The retinal nerve fiber layer thickness reaches the floor earlier than the visual field during the course of glaucoma. Visual field rather than retinal nerve fiber layer thickness is useful for disease monitoring in advanced glaucoma. Weinreb et al (see page 738) In a trial of 413 subjects randomised to one of 4 concentrations of latanoprostene bunod (LBN), or latanoprost, LBN 0.024% was the lower of the two most effective concentrations evaluated with significantly greater IOP lowering and similar side effects to latanoprost 0.005%. Choi et al (see page 746) In a study of 82 normal-tension glau...
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

Technique for identifying Schlemm's canal in paediatric glaucoma surgery
Introduction Traditionally, trabeculotomy is the preferred initial surgical intervention for congenital glaucoma when corneal haze precludes the performance of a goniotomy.1 It was first described by Burian in 1960.2 In the classical trabeculotomy ab externo, an external approach is used to cannulate the Schlemm's canal (SC) and connect it to the anterior chamber through incision of the trabecular meshwork using the trabeculotome. Recent modifications of trabeculotomy include circumferential suture techniques with or without the use of flexible illuminated microcatheter and viscotrabeculotomy.3–5 The most critical st...
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Medsinge, A., Nischal, K. K. Tags: Letters Source Type: research

Endothelial cell loss following tissue harvesting by pneumodissection for endothelial keratoplasty: an ex vivo study
Conclusions Corneal endothelial cell loss in PDEK tissue preparation is no worse, if not slightly better than, in DMEK tissue prepared by pneumodissection. PDEK preparation by pneumodissection represents a viable graft preparation technique. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Altaan, S. L., Gupta, A., Sidney, L. E., Elalfy, M. S., Agarwal, A., Dua, H. S. Tags: Ophthalmologic surgical procedures Original articles - Laboratory science Source Type: research

Prevention of allergic conjunctivitis in mice by a rice-based edible vaccine containing modified Japanese cedar pollen allergens
Conclusions Oral immunotherapy with transgenic rice expressing modified Japanese cedar pollen allergens suppressed pollen-induced experimental allergic conjunctivitis in mice by eliciting immune tolerance. This novel prophylactic approach is potentially safe and effective for allergen-specific oral immunotherapy in allergic conjunctivitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Fukuda, K., Ishida, W., Harada, Y., Wakasa, Y., Takagi, H., Takaiwa, F., Fukushima, A. Tags: Conjunctiva, Ocular surface Original articles - Laboratory science Source Type: research

Retinal pigment epithelial cells display specific transcriptional responses upon TNF-{alpha} stimulation
Conclusions This study provides insight into the unique responses of RPE cells to TNF-α stimulation and suggests a role for genes involved in apoptosis and retinal epithelial development. These findings contribute to our understanding of the behaviour of RPE cells under inflammatory conditions and the crucial role of RPE cells in vitreoretinal diseases. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Korthagen, N. M., van Bilsen, K., Swagemakers, S. M. A., van de Peppel, J., Bastiaans, J., van der Spek, P. J., van Hagen, P. M., Dik, W. A. Tags: Retina, Vitreous Original articles - Laboratory science Source Type: research

Association analysis of TGFBR3 gene with Behcet's disease and idiopathic intermediate uveitis in a Caucasian population
Conclusions RS1805110 is not associated with BD or IIU in Caucasian patients. The T allele frequency is consistent with that presented for Caucasian populations in the HapMap database (p>0.05). Our results differ from the previous analysis in Han Chinese patients (p<0.0001), however, the possibility of having a much smaller effect due to the low minority frequency cannot be excluded. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Barry, R. J., Alsalem, J. A., Faassen, J., Murray, P. I., Curnow, S. J., Wallace, G. R. Tags: Choroid, Ciliary body Original articles - Laboratory science Source Type: research

The development of infantile nystagmus
Conclusions These findings imply that developmental waveform changes are associated with improved visual acuity but only until 1.5–2 years of age. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Theodorou, M., Clement, R., Taylor, D., Moore, A. Tags: Original articles - Clinical science Source Type: research

Long-term surgical outcomes of infantile-onset esotropia in preterm patients compared with full-term patients
Conclusions The results of this study showed a favourable outcome using a mildly reduced amount of surgery in preterm patients with infantile-onset esotropia. Surgical dose–response was significantly greater in preterm patients than in full-term patients. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Park, K.-A., Oh, S. Y. Tags: Paediatrics, Muscles, Neurology Original articles - Clinical science Source Type: research

Changes in refractive error in patients with accommodative esotropia after being weaned from hyperopic correction
Conclusions When emmetropisation occurs early in patients with AET, it is necessary to note the development of myopia and the deterioration of ocular alignment. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Cho, Y. A., Ryu, W. Y. Tags: Muscles, Optic nerve, Neurology, Optics and refraction Original articles - Clinical science Source Type: research

Peripheral refraction in 7- and 14-year-old children in central China: the Anyang Childhood Eye Study
Conclusions Myopic children in mainland China have relative peripheral hyperopia while hyperopic and emmetropic children have relative peripheral myopia. Significant differences exist between 7- and 14-year-old children, with the latter showing more relative peripheral hyperopia, greater rate of change in J45 across the visual field, and higher peripheral J180. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Li, S.-M., Li, S.-Y., Liu, L.-R., Zhou, Y.-H., Yang, Z., Kang, M.-T., Li, H., Yang, X.-Y., Wang, Y.-P., Zhan, S.-Y., Mitchell, P., Wang, N., Atchison, D. A., the Anyang Childhood Eye Study Group Tags: Optic nerve, Optics and refraction Original articles - Clinical science Source Type: research

Comparison of umbilical cord serum and amniotic membrane transplantation in acute ocular chemical burns
Conclusions Our study suggests that the UCS therapy may be a better alternative to AMT in acute moderate to severe (grades III, IV and V) ocular chemical burns, as it avoids surgical manoeuvre in already inflamed eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Sharma, N., Lathi, S. S., Sehra, S. V., Agarwal, T., Sinha, R., Titiyal, J. S., Velpandian, T., Tandon, R., Vajpayee, R. B. Tags: Eye Lids Original articles - Clinical science Source Type: research

Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain
Conclusions NOP features are common in patients with symptomatic dry eye and these features correlate with symptom severity and persistence. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Galor, A., Zlotcavitch, L., Walter, S. D., Felix, E. R., Feuer, W., Martin, E. R., Margolis, T. P., Sarantopoulos, K. D., Levitt, R. C. Tags: Neurology, Epidemiology Original articles - Clinical science Source Type: research

Long-term efficacy and complications of black diaphragm intraocular lens implantation in patients with traumatic aniridia
Conclusions Glaucoma, corneal decompensation, limbal stem cell failure, and eccentric BDI lenses appeared to be the major long-term complications in BDI lens implantation. BDI lens implantation could effectively improve postoperative outcomes by reducing glare disability, improving visual performance, and addressing cosmetic issues. Because the implantation of the BDI lens in traumatic aniridia had a high incidence of complications, this treatment should be used with caution, and the long-term complications should be seriously considered. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Qiu, X., Ji, Y., Zheng, T., Lu, Y. Tags: Ophthalmologic surgical procedures, Angle, Eye (globe), Intraocular pressure, Iris, Glaucoma Original articles - Clinical science Source Type: research

Comparison of ketorolac 0.4% and nepafenac 0.1% for the prevention of cystoid macular oedema after phacoemulsification: prospective placebo-controlled randomised study
Conclusions Used prophylactically after uneventful cataract surgery, non-steroidal anti-inflammatory drugs were not efficacious in preventing macular oedema compared with placebo. Trial registration number ClinicalTrials: NCT02084576. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Tzelikis, P. F., Vieira, M., Hida, W. T., Motta, A. F., Nakano, C. T., Nakano, E. M., Alves, M. R. Tags: Ophthalmologic surgical procedures, Lens and zonules, Retina, Editor's choice Original articles - Clinical science Source Type: research

Ophthalmic manifestations of perinatally acquired HIV in a US cohort of long-term survivors
Conclusions In the post-HAART era, long-term survivors of perinatally acquired HIV exhibited little vision-threatening disease, but had a high prevalence of strabismus. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Rutar, T., Youm, J., Porco, T., Tilton, N., Muskat, M., McNamara, N., Wara, D. Tags: Conjunctiva, Cornea, Eye (globe), Lacrimal gland, Muscles, Ocular surface, Retina, Tears, Neurology Original articles - Clinical science Source Type: research

New insights into oculodermal nevogenesis and proposal for a new iris nevus classification
Conclusions Based on our findings we propose classifying iris nevi into sectoral, incomplete sectoral and solitary subtypes. Additionally, we set up a hypothetic concept of oculodermal nevogenesis suggesting a time-dependent embryogenic alteration affecting the normal melanocyte location, migration and maturation along peripheral nerve sheets. Our new concept explains well the morphology and extension of benign melanocytic proliferations in the ocular region as well as their relation to uveal melanoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Schwab, C., Zalaudek, I., Mayer, C., Riedl, R., Wackernagel, W., Juch, H., Aigner, B., Brunasso, A. M., Langmann, G., Richtig, E. Tags: Original articles - Clinical science Source Type: research

Retinal detachment in England: database studies of trends over time and geographical variation
Conclusions Admission rates seem to have increased in recent years. This increase is probably attributable to an increase in the prevalence of diabetes, and so an increase in RD associated with diabetes. Understanding trends over time, and geographical variation, in RD will help match capacity in retinal surgery with need for treatment of RD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Shah, V., Hall, N., Goldacre, M. J. Tags: Retina Original articles - Clinical science Source Type: research

Does ocriplasmin affect the RPE-photoreceptor adhesion in macular holes?
Conclusions Data on ocriplasmin remain controversial. We report on four cases with resolution of VMT following PPV after unsuccessful ocriplasmin treatment. Newly developed subretinal fluid has been described after ocriplasmin treatment, predominantly in cases with resolution of VMT. We also detected this newly developed subretinal fluid after vitrectomy, which persisted for several weeks up to 7 months in two cases with FTMHs. This may be attributable to loosening of the photoreceptor complex due to enzyme activity of ocriplasmin. Long-term effects of ocriplasmin are still to be evaluated using SD-OCT. (Source: Briti...
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Hager, A., Seibel, I., Riechardt, A., Rehak, M., Joussen, A. M. Tags: Ophthalmologic surgical procedures, Retina Original articles - Clinical science Source Type: research

Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopathy: implications for M2 macrophage-involving fibrovascular membrane formation
Conclusions These findings indicate that the M2 polarisation of macrophages is induced by M-CSF and IL-13 in diabetic retinas. The presence of M-CSF and IL-13 would then promote FVM formation by periostin production. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Yoshida, S., Kobayashi, Y., Nakama, T., Zhou, Y., Ishikawa, K., Arita, R., Nakao, S., Miyazaki, M., Sassa, Y., Oshima, Y., Izuhara, K., Kono, T., Ishibashi, T. Tags: Retina Original articles - Clinical science Source Type: research

EVEREST study report 2: imaging and grading protocol, and baseline characteristics of a randomised controlled trial of polypoidal choroidal vasculopathy
Conclusions The imaging and grading protocols and baseline characteristics of a multicentre, randomised controlled trial of PCV are described in detail, and may serve as reference for future randomised, controlled trials on PCV. Clinical trial number This work was supported by Novartis Pharma AG, Basel, Switzerland grant number NCT00674323 (clinicaltrials.gov). (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Tan, C. S., Ngo, W. K., Chen, J. P., Tan, N. W., Lim, T. H., on behalf of the EVEREST Study Group, Koh, A., Lee, W. K., Chen, L.-J., Chen, S.-J., Kim, H. Y., Lai, T. Y., Ruamviboonsuk, P. Tags: Choroid, Open access, Epidemiology Original articles - Clinical science Source Type: research

One year results of a phase 1 study of the safety and tolerability of combination therapy using sustained release intravitreal triamcinolone acetonide and ranibizumab for subfoveal neovascular AMD
Conclusions Combination therapy IBI-20089 and ranibizumab was well-tolerated and resulted in fewer ranibizumab retreatments. Transient intraocular pressure elevation and cataract progression occurred. Trial registration number NCT01175395. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Lim, J. I., Niec, M., Wong, V. Tags: Lens and zonules, Retina Original articles - Clinical science Source Type: research

Impact of superior and inferior visual field loss on hazard detection in a computer-based driving test
Conclusions In this study, simulated VF defects impaired the ability to detect driving hazards relative to participants’ normal performances, with superior defects having more impact than inferior defects. These results could help inform the design of fairer tests of the VF component for fitness to drive. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Glen, F. C., Smith, N. D., Crabb, D. P. Tags: Original articles - Clinical science Source Type: research