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Correction
Hajari JN, Kyhnel A, Bech-Azeddine J, et al. Progression of foveola-on rhegmatogenous retinal detachment. Br J Ophthalmol 2014;98:1534–1538. In figure 3 it is indicated in the first column that 1 percent of cases progress. This is wrong. It should state that 4 percent progress. The column wrongfully indicates the number of cases that progress instead of the percentage of cases. Please see below for correct figure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Tags: Corrections Source Type: research

Comparative histology of orbital, hepatic and subcutaneous cavernous venous malformations
We examined four representative, consecutive cases with a pathological diagnosis of cavernous malformation found in the liver, skin and orbit, respectively. A total of 12 cases were reviewed. All slides were stained as previously described.3 Morphological analysis revealed flat, mature vascular endothelium staining uniformly for CD31 without elastic lamina in all specimens. Vascular spaces were arranged in a back-to-back fashion, giving all cases a classic cavernous malformation appearance (figure 1A–C). Hepatic lesions tended to have minimal stroma, with... (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Rootman, D. B., Rootman, J., White, V. A. Tags: Letters Source Type: research

Ciliary neurotrophic factor (CNTF)-mediated ganglion cell survival in a rodent model of non-arteritic anterior ischaemic optic neuropathy (NAION)
Conclusions CNTF exerts a neuroprotective effect in ischaemic optic nerve injury and promotes RGC survival, suggesting that CNTF may be effective in the clinical treatment of human NAION. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Mathews, M. K., Guo, Y., Langenberg, P., Bernstein, S. L. Tags: Optic nerve, Neurology Original articles - Laboratory science Source Type: research

Toll-like receptor 3 activation drives the inflammatory response in oxygen-induced retinopathy in rats
Conclusions Our results suggest that upregulation of the TLR3 signalling pathway is involved in the pro-inflammatory response in OIR rat retinas. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Cai, M., Zhang, X., Li, Y., Xu, H. Tags: Retina, Vision, Neurology Original articles - Laboratory science Source Type: research

Assessment of laser induction of Bruch's membrane disruption in monkey by spectral-domain optical coherence tomography
Conclusions The presence of subretinal bubbles with haemorrhage is not an accurate indicator for successful disruption of the Bruch's membrane. Instead, spectral-domain OCT provides a better alternative to assess the retinal damages to the Bruch's membrane during laser induction of choroidal neovascularisation in monkeys. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Wang, Q., Lin, X., Xiang, W., Xiao, W., He, M. Tags: Ophthalmologic surgical procedures, Choroid, Retina Original articles - Laboratory science Source Type: research

A comparison of methods used to evaluate mobility performance in the visually impaired
Conclusions A validated scoring system based on errors is more effective when assessing visual disability during mobility testing than recording the time taken for course completion. The combined metric of ADREV errors noted divided by time taken was most predictive of all the methods used to evaluate visual disability during mobility testing. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Warrian, K. J., Katz, L. J., Myers, J. S., Moster, M. R., Pro, M. J., Wizov, S. S., Spaeth, G. L. Tags: Angle, Intraocular pressure, Retina, Glaucoma Original articles - Clinical science Source Type: research

Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen's disease: a tear proteomic study
Conclusions In moderate to severe dry eye in Hansen's disease, serum therapy in comparison with AT drops, improves clinical parameters and causes betterment in tear protein profile. Trial registration number CTRI/2013/07/003802. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Mukhopadhyay, S., Sen, S., Datta, H. Tags: Original articles - Clinical science Source Type: research

Infectious involvement in a tertiary center pediatric uveitis cohort
Conclusions An infectious cause of uveitis was identified in 17% of children with uveitis. T gondii and VZV were the most prevalent pathogens. We recommend analysing the aqueous humour of every child with vision-threatening uveitis of undetermined origin. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Hettinga, Y. M., de Groot-Mijnes, J. D. F., Rothova, A., de Boer, J. H. Tags: Epidemiology Original articles - Clinical science Source Type: research

Cystoid macular oedema following Descemet membrane endothelial keratoplasty
Conclusions CMO is a frequent complication following DMEK in phacic and pseudophacic eyes. The prognosis is excellent given medical treatment. We recommend regular SD-OCT monitoring during the first 6 months following DMEK. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Heinzelmann, S., Maier, P., Bohringer, D., Huther, S., Eberwein, P., Reinhard, T. Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Lens and zonules, Ocular surface Original articles - Clinical science Source Type: research

Efficacy and safety of intravitreal aflibercept injection in wet age-related macular degeneration: outcomes in the Japanese subgroup of the VIEW 2 study
Conclusions IVT-AFL was effective and well tolerated in Japanese patients. Outcomes in this population were consistent with those in the overall VIEW 2 population. Trial registration number NCT00637377. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Ogura, Y., Terasaki, H., Gomi, F., Yuzawa, M., Iida, T., Honda, M., Nishijo, K., Sowade, O., Komori, T., Schmidt-Erfurth, U., Simader, C., Chong, V., for the VIEW 2 Investigators Tags: Retina, Open access, Epidemiology Original articles - Clinical science Source Type: research

Mycophenolic acid in the treatment of birdshot chorioretinopathy: long-term follow-up
Conclusions Derivatives of mycophenolic acid are effective and safe drugs for the treatment of BSCR. In cases with gastrointestinal side effects, a therapy switch from MMF to MPS should be considered. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Doycheva, D., Jagle, H., Zierhut, M., Deuter, C., Blumenstock, G., Schiefer, U., Stingl, K., Januschowski, K., Voykov, B., Stuebiger, N. Tags: Original articles - Clinical science Source Type: research

Evaluation of iris and iridociliary body lesions with anterior segment optical coherence tomography versus ultrasound B-scan
Conclusions AS-OCT is superior to USB for imaging small lesions pertaining to the anterior iris but USB is better for imaging larger iris lesions with posterior or ciliary body extension. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Hau, S. C., Papastefanou, V., Shah, S., Sagoo, M. S., Restori, M., Cohen, V. Tags: Open access Original articles - Clinical science Source Type: research

Brilliant blue G assisted macular surgery: the effect of air infusion on contrast recognisability in internal limiting membrane peeling
Conclusions BBG under air infusion yields a significantly higher contrast staining and easy peeling of ILM associated with anatomical and functional improvement and no retinal toxicity after macular surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Totan, Y., Guler, E., Gurağac, F. B., Uzun, E., Doğdu, E. Tags: Lens and zonules, Retina Original articles - Clinical science Source Type: research

The effect of myopic optic disc tilt on measurement of spectral-domain optical coherence tomography parameters
Conclusions The diagnostic capacities of temporal RNFL thickness and vertical CDR should be interpreted with caution in glaucomatous eyes with tilted optic discs. Macular GCIPL measurement provides reliable diagnostic parameters, regardless of the degree of optic disc tilt. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Shin, H.-Y., Park, H.-Y. L., Park, C. K. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Prevalence of diabetic retinopathy within a national diabetic retinopathy screening service
Conclusions Prevalence of DR within the largest reported community-based, quality assured, DR screening programme, was higher in persons with type 1 diabetes; however, the major burden is represented by type 2 diabetes which is 94% of the screened population. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Thomas, R. L., Dunstan, F. D., Luzio, S. D., Chowdhury, S. R., North, R. V., Hale, S. L., Gibbins, R. L., Owens, D. R. Tags: Retina, Pupil, Epidemiology Original articles - Clinical science Source Type: research

Amniotic membrane graft to conjunctival flap in treatment of non-viral resistant infectious keratitis: a randomised clinical study
Conclusions CF and AMG are effective in treatment-resistant infectious keratitis. They could restore ocular surface integrity and provide metabolic and mechanical support for corneal healing. For large corneal perforation, it may be better to use another procedure such as penetrating keratoplasty to restore ocular integrity. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Abdulhalim, B.-E. H., Wagih, M. M., Gad, A. A. M., Boghdadi, G., Nagy, R. R. S. Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study
Conclusions CMV endotheliitis is most common in middle-aged and elderly men. CMV endotheliitis should be suspected when patients present with corneal endotheliitis involving coin-shaped lesions accompanied by anterior uveitis and ocular hypertension. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Koizumi, N., Inatomi, T., Suzuki, T., Shiraishi, A., Ohashi, Y., Kandori, M., Miyazaki, D., Inoue, Y., Soma, T., Nishida, K., Takase, H., Sugita, S., Mochizuki, M., Kinoshita, S., for the Japan Corneal Endotheliitis Study Group Tags: Public health, Angle, Choroid, Intraocular pressure, Open access Original articles - Clinical science Source Type: research

Cyclotorsional and non-cyclotorsional components of eye rotation observed from sitting to supine position
This study demonstrates that most of the rotations previously attributed to torsional components were probably due to NCYs, such as postural misalignments. Apparently, the amplitude of cyclotorsional movements is smaller than observed in previous reports, and could not be associated with any studied variable. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Prickett, A. L., Bui, K., Hallak, J., Bakhtiyari, P., de la Cruz, J., Azar, D. T., Chamon, W. Tags: Original articles - Clinical science Source Type: research

Predicting proliferative vitreoretinopathy: temporal and external validation of models based on genetic and clinical variables
Conclusions Genetic profiling of patients with RRD can improve the predictability of PVR in addition to the well-known clinical biomarkers. This validated formula could be a new tool in our current clinical practice in order to identify those patients at high risk of developing PVR. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Rojas, J., Fernandez, I., Pastor, J. C., MacLaren, R. E., Ramkissoon, Y., Harsum, S., Charteris, D. G., Van Meurs, J. C., Amarakoon, S., Garcia-Arumi, J., Ruiz-Moreno, J. M., Rocha-Sousa, A., Brion, M., Carracedo, A., for the Genetics on PVR Study Group ( Tags: Retina, Vitreous Original articles - Clinical science Source Type: research

Silicone band loop myopexy in the treatment of myopic strabismus fixus: surgical outcome of a novel modification
Conclusions Modified scleral fixated silicone band loop myopexy with or without MR recession is a safe and effective procedure in the management of MSF and improves alignment significantly. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Shenoy, B. H., Sachdeva, V., Kekunnaya, R. Tags: Muscles, Neurology Original articles - Clinical science Source Type: research

En-face high-penetration optical coherence tomography imaging in polypoidal choroidal vasculopathy
Conclusions HP-OCT can visualise choroidal vascular abnormalities in eyes with PCV and should be useful for understanding the pathogenesis of these abnormalities. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Sayanagi, K., Gomi, F., Akiba, M., Sawa, M., Hara, C., Nishida, K. Tags: Choroid Original articles - Clinical science Source Type: research

Granular corneal dystrophy type 2 is associated with morphological abnormalities of meibomian glands
Conclusions In GCD2, corneal deposits, and also morphological abnormalities of meibomian glands, such as obstruction or shortening, were found. Since abnormal phospholipid deposition is noted in GCD2, these results are interesting because phospholipid is possibly secreted from the meibomian gland. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Sakimoto, T. Tags: Original articles - Clinical science Source Type: research

Structural glaucomatous progression before and after occurrence of an optic disc haemorrhage
Conclusions Patients show structural glaucomatous progression before and after the event of a disc haemorrhage without significant differences. This suggests that a DH is an ongoing structural progression in glaucoma and may not be a discrete event that leads to subsequent progression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Chung, E., Demetriades, A. M., Christos, P. J., Radcliffe, N. M. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

The Spaeth/Richman contrast sensitivity test (SPARCS): design, reproducibility and ability to identify patients with glaucoma
Conclusions SPARCS has high test-retest reliability. It is easily accessible via the internet and identifies patients with glaucoma well. Trial Registration: NCT01300949. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Richman, J., Zangalli, C., Lu, L., Wizov, S. S., Spaeth, E., Spaeth, G. L. Tags: Angle, Intraocular pressure, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Validation of a new static perimetric thresholding strategy (GATE)
Conclusions GATEp and GATE, implemented in the commercially available EyeSuite software package (GATEe), show good agreement regarding local differential luminance sensitivity. GATEe can thus be also recommended for clinical practice. Clinical trial number NCT01265628. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Luithardt, A. F., Meisner, C., Monhart, M., Krapp, E., Mast, A., Schiefer, U. Tags: Angle, Eye (globe), Intraocular pressure, Optic nerve, Retina, Neurology, Glaucoma Original articles - Clinical science Source Type: research

Using continuous intraoperative optical coherence tomography measurements of the aphakic eye for intraocular lens power calculation
Conclusions ACDIntraOP measurements help to better predict the refractive outcome and could be useful, if implemented in fourth-generation IPC formulae. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Hirnschall, N., Norrby, S., Weber, M., Maedel, S., Amir-Asgari, S., Findl, O. Tags: Optic nerve, Optics and refraction Original articles - Clinical science Source Type: research

Iris stromal imbrication oversewing for pigment epithelial defects
We present a novel iris repair technique for the management of iris transillumination defects secondary to iris pigment epithelium (IPE) loss, which includes iris oversewing over the defect through partial iris stromal bites with 10-0 polypropylene. This technique provides a healthy layer of iris covering the transillumination defect without the creation of new defects on the contiguous IPE. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Snyder, M. E., Perez, M. A. Tags: Innovations Source Type: research

Life expectancy following orbital exenteration
Orbital exenteration is a physically debilitating procedure that may be a necessity in the management of orbital malignancy. It requires a sensitive multidisciplinary approach, both preoperatively and postoperatively. Providing life expectancy information for patients during preoperative counselling is pertinent to informed consent and in addressing patients’ expectations. A retrospective review from one tertiary care centre was undertaken for a cohort of patients who were exenterated for orbital malignancy between 1998 and 2010. The cases were identified using an International Classification of Diseases 10th Revisio...
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Wong, J. C. L., Thampy, R., Cook, A. Tags: Review Source Type: research

Highlights from this issue
Wong et al (page 1) A retrospective review of 73 patients who were exenterated for orbital malignancy betewen 1998 and 2010 reporting a 5-year survival of 64%. Histological diagnosis influences statistical significance on life expectancy, whereas surgical margins do not. Overall prognosis for patients remains poor. Snyder et al (page 5) Temporal iris stromal atrophy can occur from iris prolapse during phaco, especially in floppy iris. Imbricating iris stromal oversewing of the anterior stroma can reduce or eliminate glare from focal transillumination. Findl et al (page 7) A novel concept of intra-operative optical coherenc...
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

Correction
Chan E, Jhanji V, Constantinou M, Amiel H, Snibson GR, Vajpayee RB. A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. Br J Ophthalmol 2014;98:166–71. A letter by Prakash and Jain was published in response to this article that includes a corrected figure from the original manuscript. Please see the letter by Chan E, Jhanji V, Constantinou M, et al. Br J Ophthalmol 2014;98:278–9 for the corrected figure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Tags: Corrections Source Type: research

Spectroscopic measurements in scleritis: Bluish-red or deep red?
Conclusions Reproducible measurements of the eye were made using an innovative, slit-lamp mountable spectrometer and its functionality demonstrated by differentiating the spectra from eyes with differing pathologies. While intending only to illustrate one potential application; for the cases examined, our results indicate that inflamed scleritic eyes exhibit a longer wavelength red light with no increase in shorter wavelength blue light. Thus our measurements would seem to confirm that the perceived redness of scleritis differs from other red eyes. However, it is a deeper darker red and not a bluish one as traditionally de...
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Bannister, N. P., Wakefield, M. J., Tatham, A., Bugby, S. L., Molyneux, P. M., Prydal, J. I. Tags: Sclera and apisclera Innovations Source Type: research

Corneal tolerance to micronised mineral pigments for keratopigmentation
Conclusions Micronised mineral pigments could be a valid alternative treatment for cosmetic keratopigmentation. The intralamellar keratopigmentation technique presented good cosmetic appearance without adverse effects in the eyes treated. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Amesty, M. A., Alio, J. L., Rodriguez, A. E. Tags: Original articles - Laboratory science Source Type: research

Inhibition by rebamipide of cytokine-induced or lipopolysaccharide-induced chemokine synthesis in human corneal fibroblasts
Conclusions Rebamipide inhibited the synthesis of chemokines by corneal fibroblasts in association with suppression of NFB signalling. Rebamipide may therefore prove effective for the treatment of corneal stromal inflammation associated with allergy or bacterial infection. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Fukuda, K., Ishida, W., Tanaka, H., Harada, Y., Fukushima, A. Tags: Original articles - Laboratory science Source Type: research

Serum-free medium and hydroxyethyl starch supports cell survival better than Minimal Essential Medium and dextran in organ-cultured mouse corneas
Conclusions Serum-free medium, Human Endothelial-SFM, promoted cell survival during corneal organ culture better than MEM+2% FCS. HES 130/0.4 appeared to be tolerated better by the cells than dextran T500. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Knels, L., Goetze, D., Engelmann, K., Valtink, M. Tags: Original articles - Laboratory science Source Type: research

Prognostic parameters in uveal melanoma and their association with BAP1 expression
Conclusions Loss of BAP1 expression associated well with all of the methods currently used for prognostication and was itself predictive of death due to metastasis in uveal melanoma after enucleation, thereby emphasising the importance of further research on the role of BAP1 in uveal melanoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: van Essen, T. H., van Pelt, S. I., Versluis, M., Bronkhorst, I. H., van Duinen, S. G., Marinkovic, M., Kroes, W. G., Ruivenkamp, C. A., Shukla, S., de Klein, A., Kilic, E., Harbour, J. W., Luyten, G. P., van der Velden, P. A., Verdijk, R. M., Jager, M. J. Tags: Eye (globe) Original articles - Laboratory science Source Type: research

High C4 gene copy numbers protects against Vogt-Koyanagi-Harada syndrome in Chinese Han
Conclusions Our findings indicate a decreased expression of serum C4 and a decreased frequency of high C4 gene copy number in patients with VKH. Trial registration number Chinese Clinical Trial Registration Number: ChiCTR-CCC-12002184. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Hou, S., Qi, J., Liao, D., Fang, J., Chen, L., Kijlstra, A., Yang, P. Tags: Original articles - Laboratory science Source Type: research

Risk characteristics of the combined geographic atrophy and choroidal neovascularisation phenotype in age-related macular degeneration
Conclusions The combined GA/CNV phenotype has similar epidemiologic, clinical, and genetic features as GA and CNV, but occurs at an older age and is more associated with advanced AMD in the fellow eye, suggesting that all these phenotypes are part of the same spectrum of disease and that the combined phenotype represents an even more advanced form of AMD than either GA or CNV. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Saade, C., Ganti, B., Marmor, M., Freund, K. B., Smith, R. T. Tags: Choroid, Retina, Epidemiology Original articles - Clinical science Source Type: research

Genetic analysis of strictly defined Leber congenital amaurosis with (and without) neurodevelopmental delay
Conclusions Neurodevelopmental delay is a potential feature of strictly defined LCA, documented in our series for some children with homozygous RPGRIP1 and GUCY2D mutations. Strictly defining LCA can limit genetic heterogeneity. On the Arabian Peninsula, the phenotype is frequently from recessive RPGRIP1 mutations, most of which are a founder RPGRIP1 deletion. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Khan, A. O., Al-Mesfer, S., Al-Turkmani, S., Bergmann, C., Bolz, H. J. Tags: Vision, Neurology Original articles - Clinical science Source Type: research

Novel ADAM9 homozygous mutation in a consanguineous Egyptian family with severe cone-rod dystrophy and cataract
Conclusions and relevance We identified a novel autosomal recessive ADAM9 mutation causing arCRD in a consanguineous Egyptian family. The percentage of arCRD cases caused by mutation in ADAM9 remains to be determined. Few families are reported in the literature to date; hence extensive clinical descriptions of families with ADAM9 mutations are of significant importance. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: El-Haig, W. M., Jakobsson, C., Favez, T., Schorderet, D. F., Abouzeid, H. Tags: Public health, Angle, Eye (globe), Intraocular pressure, Lens and zonules, Retina, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Prevalence and risk factors of dry eye disease in a British female cohort
Conclusions DED is common and increases with age within this cohort of female twins. We confirmed established risk factors for the first time in a British population, and found important risk factors that might relate to an underlying aetiology involving chronic pain predisposition or somatisation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Vehof, J., Kozareva, D., Hysi, P. G., Hammond, C. J. Tags: Lens and zonules, Press releases, Neurology Original articles - Clinical science Source Type: research

Randomised masked clinical trial of the MGDRx eyebag for the treatment of meibomian gland dysfunction-related evaporative dry eye
Conclusions The MGDRx EyeBag is a safe and effective device for the treatment of MGD-related evaporative dry eye. Subjective benefit lasts at least 6 months, aided by occasional retreatment. Trial registration number NCT01870180. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Bilkhu, P. S., Naroo, S. A., Wolffsohn, J. S. Tags: Open access Original articles - Clinical science Source Type: research

Long-term outcomes of optical coherence tomography-guided transepithelial phototherapeutic keratectomy for the treatment of anterior corneal scarring
Conclusions The OCT-guided transepithelial PTK technique described in this study can deliver positive long-term results and predictable refractive outcomes in the treatment of anterior corneal scarring. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Rush, S. W., Matulich, J., Rush, R. B. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Estimation of ocular volume from axial length
Conclusion Clinically useful estimations of ocular volume can be obtained from measurement of AL and CR. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Nagra, M., Gilmartin, B., Logan, N. S. Tags: Original articles - Clinical science Source Type: research

The tarsal belt procedure for the correction of ectropion: description and outcome in 42 cases
Conclusions The tarsal belt seems to be effective to correct the horizontal and vertical instability of the lid. The suture supports the lower eyelid along the entire tarsal plate length and corrects the outward buckling of the tarsal plate. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Pascali, M., Corsi, A., Brinci, L., Corsi, I., Cervelli, V. Tags: Eye Lids Original articles - Clinical science Source Type: research

Outcomes of posterior-approach 'levatorpexy' in congenital ptosis repair
Conclusions Posterior approach levatorpexy appears to be a safe and effective procedure for correction of congenital ptosis particularly with moderate or better levator function. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: AL-Abbadi, Z., Sagili, S., Malhotra, R. Tags: Original articles - Clinical science Source Type: research

Number of excisions required to obtain clear surgical margins and prognostic value of AJCC T category for patients with eyelid melanoma
Conclusions More than a third of patients with eyelid melanoma required more than 1 excision to achieve clear margins, supporting delayed reconstruction for eyelid melanoma. Nodal metastasis at presentation was significantly correlated with AJCC T category and time to progression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Yin, V. T., Warneke, C. L., Merritt, H. A., Esmaeli, B. Tags: Original articles - Clinical science Source Type: research

Long-term outcomes in primary powered endoscopic dacryocystorhinostomy
Conclusions Powered endoscopic DCR is a safe procedure and offers excellent long-term results. Adjunctive endonasal procedures should be performed where indicated. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Ali, M. J., Psaltis, A. J., Bassiouni, A., Wormald, P. J. Tags: Ophthalmologic surgical procedures, Lacrimal gland, Tears Original articles - Clinical science Source Type: research

Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction
Conclusions Obstructive sialadenitis of transplanted SMGs is a chronic inflammation secondary to ductal obstruction, which leads to insufficient ocular lubrication and potential treatment failure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Su, J.-Z., Yang, N.-Y., Liu, X.-J., Cai, Z.-G., Lv, L., Zhang, L., Wu, L.-L., Liu, D.-G., Ren, W.-G., Gao, Y., Yu, G.-Y. Tags: Conjunctiva, Cornea, Lacrimal gland, Ocular surface, Tears Original articles - Clinical science Source Type: research

Retcam fluorescein angiography findings in eyes with advanced retinoblastoma
Conclusions Advanced intraocular retinoblastoma is associated with multiple retinal vascular abnormalities on Retcam FA. These findings may be helpful in defining the extent of disease and distinguishing this tumour from other paediatric ocular conditions. Key clinical findings were subclinical iris neovascularisation, a variety of small vessel changes, intrinsic tumour vessels and retinal venous leakage. Retcam FA was not found to be clinically useful after 3 min. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Kim, J. W., Ngai, L. K., Sadda, S., Murakami, Y., Lee, D. K., Murphree, A. L. Tags: Original articles - Clinical science Source Type: research

Metabolic activity of primary uveal melanoma on PET/CT scan and its relationship with monosomy 3 and other prognostic factors
Conclusions Metabolic activity of uveal melanoma on PET/CT scan is positively correlated with monosomy 3, increasing tumour size and TNM prognostic groups. No association with chromosome 8 gain or histopathology cell type was noted. SUVmax >4 is a relative but not an absolute indicator of monosomy 3 status. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 14, 2014 Category: Opthalmology Authors: Papastefanou, V. P., Islam, S., Szyszko, T., Grantham, M., Sagoo, M. S., Cohen, V. M. L. Tags: Eye (globe), Open access, Epidemiology Original articles - Clinical science Source Type: research