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Safety profile of accelerated corneal cross-linking versus conventional cross-linking: a comparative study on ex vivo-cultured limbal epithelial cells
Conclusions The 30 mW UV-A irradiation used in ACXL appears to be safe on cultured LECs in comparison with 3 mW used in CXL. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Shetty, R., Matalia, H., Nuijts, R., Subramani, M., Dhamodaran, K., Pandian, R., Jayadev, C., Das, D. Tags: Original articles - Laboratory science Source Type: research

Use of human serum for human corneal endothelial cell culture
Conclusions HS-SM was similar to FBS-SM for HCEC culture when assessed by cell morphology, proliferation and protein/gene expression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Vianna, L. M. M., Kallay, L., Toyono, T., Belfort, R., Holiman, J. D., Jun, A. S. Tags: Original articles - Laboratory science Source Type: research

Changes in angle of optic nerve and angle of ocular orbit with increasing age in Japanese children
Conclusions Because the opening angle of the orbit decreased significantly with increasing age, this factor must be considered when diagnosing and treating strabismus in children. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Tsukitome, H., Hatsukawa, Y., Morimitsu, T., Yagasaki, T., Kondo, M. Tags: Muscles, Open access, Neurology Original articles - Clinical science Source Type: research

Outcomes of ab interno trabeculectomy with the trabectome after failed trabeculectomy
Conclusions Both AIT and phaco-AIT showed a reduction in IOP and medication use after 1 year, suggesting that AIT with or without cataract surgery is a safe and effective option following failed trabeculectomy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Bussel, I. I., Kaplowitz, K., Schuman, J. S., Loewen, N. A., Trabectome Study Group Tags: Ophthalmologic surgical procedures, Angle, Intraocular pressure, Lens and zonules, Open access, Glaucoma Original articles - Clinical science Source Type: research

Swimming goggle wear is not associated with an increased prevalence of glaucoma
Conclusions These findings suggest that frequently wearing swim goggles does not lead to an increased risk of glaucoma over time in adults. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Franchina, M., Yazar, S., Booth, L., Wan, S. L., Cox, K., Kang, M. H., Hewitt, A. W., Mackey, D. A. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Severity of acute ocular involvement is independently associated with time to resolution of ocular disease in toxic epidermal necrolysis patients
Conclusions Grading of acute ocular disease severity does not reflect systemic disease severity and is significantly associated with resolution and time to resolution of ocular involvement in TEN. The high rate of ocular involvement in patients with TEN and relatively large proportion of patients with active disease on discharge reiterates the need for constant ophthalmological monitoring of these patients. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Heng, J. S., Malik, N., Joshi, N., Hayes, M., Jones, I., Fuller, L. C., Vizcaychipi, M. P. Tags: Original articles - Clinical science Source Type: research

A prospective, randomised comparison of probing versus bicanalicular silastic intubation for congenital nasolacrimal duct obstruction
Conclusions Probing for simple CNLDO in young children is adequate. Bicanalicular silastic intubation seems to have a role in achieving successful outcomes in complex CNLDO. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Al-Faky, Y. H., Mousa, A., Kalantan, H., Al-Otaibi, A., Alodan, H., Alsuhaibani, A. H. Tags: Paediatrics Original articles - Clinical science Source Type: research

The effects of absence of stereopsis on performance of a simulated surgical task in two-dimensional and three-dimensional viewing conditions
Conclusions High-grade stereopsis confers an advantage when performing a fine motor task under direct vision. However, stereopsis does not appear advantageous to task performance under 2D viewing conditions, such as in video-assisted surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Bloch, E., Uddin, N., Gannon, L., Rantell, K., Jain, S. Tags: Open access Original articles - Clinical science Source Type: research

Face-down positioning versus non-supine positioning in macular hole surgery
Conclusions Results from consistent FTMH repair indicate similar anatomical success rates in FDP and NSP groups, suggesting that FDP is unnecessary. Objective monitoring of positioning would be beneficial in future FTMH studies to be able to adjust for positioning protocol compliance. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Alberti, M., la Cour, M. Tags: Ophthalmologic surgical procedures, Retina Original articles - Clinical science Source Type: research

Transpalpebral proton beam radiotherapy of choroidal melanoma
Conclusions Transpalpebral PBR of choroidal melanoma avoids eyelid and ocular surface complications without increasing failure of local tumour control. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Konstantinidis, L., Roberts, D., Errington, R. D., Kacperek, A., Heimann, H., Damato, B. Tags: Original articles - Clinical science Source Type: research

The risk of acute coronary syndrome after retinal artery occlusion: a population-based cohort study
Conclusions We found that RAO increased the risk for ACS. We recommend thorough follow-up cardiovascular examinations and medical prevention for ACS in patients following RAO. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Chang, Y.-S., Chu, C.-C., Weng, S.-F., Chang, C., Wang, J.-J., Jan, R.-L. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Multi-country real-life experience of anti-vascular endothelial growth factor therapy for wet age-related macular degeneration
Conclusions In clinical practice, fewer injections are administered than in clinical trials. Anti-VEGF treatment resulted in an initial improvement in visual acuity; however, this was not maintained over time. Trial registration number NCT01447043. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Holz, F. G., Tadayoni, R., Beatty, S., Berger, A., Cereda, M. G., Cortez, R., Hoyng, C. B., Hykin, P., Staurenghi, G., Heldner, S., Bogumil, T., Heah, T., Sivaprasad, S. Tags: Retina, Open access, Editor's choice Original articles - Clinical science Source Type: research

Topical bromfenac reduces the frequency of intravitreal bevacizumab in patients with branch retinal vein occlusion
Conclusions Although topical bromfenac during IVB therapy in eyes with ME secondary to BRVO did not affect the visual prognosis, it had the advantage of reducing the number of injections. Trial registration number UMIN 14929. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Shimura, M., Yasuda, K. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Sequential therapy with ranibizumab and dexamethasone intravitreal implant is better than dexamethasone monotherapy for macular oedema due to retinal vein occlusion
Conclusions Sequential therapy was found to be more effective than dexamethasone monotherapy in treating MO due to RVO. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Iu, L. P., Zhao, P., Yeung, I. Y., Fung, N. S., Lee, J. W., Wong, R. L., Chong, V., Wong, I. Y. Tags: Retina Original articles - Clinical science Source Type: research

Characterisation of uveitis in association with multiple sclerosis
Conclusions Uveitis with MS generally presents as intermediate uveitis with a minority presenting with anterior uveitis. Patients are significantly older and more likely to be women than patients with idiopathic intermediate uveitis. The visual prognosis is generally favourable. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Messenger, W., Hildebrandt, L., Mackensen, F., Suhler, E., Becker, M., Rosenbaum, J. T. Tags: Choroid, Ciliary body, Neurology Original articles - Clinical science Source Type: research

Oral azithromycin versus doxycycline in meibomian gland dysfunction: a randomised double-masked open-label clinical trial
Conclusions Although both oral azithromycin and doxycycline improved the symptoms of MGD, 5-day oral azithromycin is recommended for its better effect on improving the signs, better overall clinical response and shorter duration of treatment. Trial registration number NCT01783860. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Kashkouli, M. B., Fazel, A. J., Kiavash, V., Nojomi, M., Ghiasian, L. Tags: Original articles - Clinical science Source Type: research

Intrastromal voriconazole for deep recalcitrant fungal keratitis: a case series
Conclusions Targeted delivery of voriconazole by intrastromal injection (50 µg/0.1 mL) is a safe and effective way to treat deep recalcitrant fungal keratitis, though some may need repeated injections. Fusarium keratitis may show suboptimal response but this needs further study. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Kalaiselvi, G., Narayana, S., Krishnan, T., Sengupta, S. Tags: Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Trends in bacterial and fungal keratitis in South India, 2002-2012
Conclusions At a tertiary eye care centre in South India, there has been a reduction in the numbers of smear-positive bacterial keratitis over the past 11 years. This decline likely reflects economic development in India and increased access to antibiotics. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Lalitha, P., Prajna, N. V., Manoharan, G., Srinivasan, M., Mascarenhas, J., Das, M., D'Silva, S. S., Porco, T. C., Keenan, J. D. Tags: Public health, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Measurement of lens density using Scheimpflug imaging system as a screening test in the field of health examination for age-related cataract
Conclusions The Pentacam ImageJ method provided objective measurements to evaluate cataracts needing surgery. The method has the potential to be generally applied in the field of health examination and is effective in screening patients with cataract. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Lim, D. H., Kim, T. H., Chung, E.-S., Chung, T.-Y. Tags: Lens and zonules, Epidemiology Original articles - Clinical science Source Type: research

Three-year follow-up of posterior chamber toric phakic intraocular lens implantation for the correction of high myopic astigmatism in eyes with keratoconus
Conclusions Toric ICL implantation is beneficial according to measures of safety, efficacy, predictability and stability for the correction of refractive errors for keratoconus during a 3-year observation period. The disease did not progress even in the late-postoperative period, suggesting the viability of this procedure as a surgical option for the treatment of such eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Kamiya, K., Shimizu, K., Kobashi, H., Igarashi, A., Komatsu, M., Nakamura, A., Kojima, T., Nakamura, T. Tags: Cornea, Ocular surface, Optic nerve, Optics and refraction Original articles - Clinical science Source Type: research

Intrastromal femtosecond laser surgical compensation of presbyopia with six intrastromal ring cuts: 3-year results
Conclusions INTRACOR with a modified pattern improved UNVA in all patients over a 36-month follow-up period. The possibility of reduced CDVA underlines the need for careful patient selection. Trial registration number NCT00928122. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Khoramnia, R., Fitting, A., Rabsilber, T. M., Thomas, B. C., Auffarth, G. U., Holzer, M. P. Tags: Optic nerve, Optics and refraction Original articles - Clinical science Source Type: research

Descemet's membrane endothelial keratoplasty (DMEK): first UK prospective study of 1-year visual outcomes, graft survival and endothelial cell count
Conclusions In our experience, DMEK has the potential to become the primary procedure for treating Fuchs’ endothelial dystrophy and endothelial disease as it produces rapid total visual rehabilitation with few complications, and an easy follow-up and management regimen. Donor preparation and graft insertion, however, remain important challenges. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Reid, R. A., Craig, E. A., Suleman, H. Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

In vivo confocal microscopic characterisation of the cornea in chronic graft-versus-host disease related severe dry eye disease
Conclusions IVCM findings of the cornea in patients with severe ocular cGvHD include a rarefaction of the sub basal corneal nerve plexus and dense accumulation of hyper-reflective extracellular matrix in the anterior stroma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Steger, B., Speicher, L., Philipp, W., Bechrakis, N. E. Tags: Lacrimal gland, Tears Original articles - Clinical science Source Type: research

Accelerated versus standard corneal collagen crosslinking combined with same day phototherapeutic keratectomy and single intrastromal ring segment implantation for keratoconus
Conclusions A combined treatment of accelerated CXL preceded by same day t-PTK and single ICRS is as effective as the combined treatment using standard CXL for visual rehabilitation in progressive keratoconus. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Elbaz, U., Shen, C., Lichtinger, A., Zauberman, N. A., Goldich, Y., Ziai, S., Rootman, D. S. Tags: Cornea, Ocular surface Original articles - Clinical science Source Type: research

Treatment of diffuse subretinal fibrosis uveitis with rituximab
We report two cases of bilateral DUS successfully treated with rituximab. We believe given the B-cell predominance in the underlying pathogenesis of the disease, rituximab should be considered first line in the management of this potentially devastating disease. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Cornish, K. S., Kuffova, L., Forrester, J. V. Tags: Choroid Innovations Source Type: research

Prevalence of corneal diseases in the rural Indian population: the Corneal Opacity Rural Epidemiological (CORE) study
Conclusions The study findings demonstrate that currently ocular trauma, infectious keratitis, post-surgical bullous keratopathy, and corneal degenerations are responsible for the major burden of corneal blindness and morbidity in the Indian population. The prevalence of corneal morbidity due to vitamin A deficiency and trachoma was low in this rural population. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Gupta, N., Vashist, P., Tandon, R., Gupta, S. K., Dwivedi, S., Mani, K. Tags: Public health, Conjunctiva, Cornea, Eye (globe), Ocular surface, Vision, Neurology, Epidemiology Global issues Source Type: research

Efficacy and adverse events of aflibercept, ranibizumab and bevacizumab in age-related macular degeneration: a trade-off analysis
Conclusions The study revealed only a modest superiority of aflibercept 2 mg and ranibizumab 0.5 mg over other formulations and dosages. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Schmid, M. K., Bachmann, L. M., Fas, L., Kessels, A. G., Job, O. M., Thiel, M. A. Tags: Retina, Neurology Review Source Type: research

Highlights from this issue
Elbaz et al (page 155) The authors report a retrospective study of 16 eyes that underwent standard or accelerated collagen cross-linking treatment for progressive keratoconus preceded by same day transepithelial phototherapeutic keratectomy and inferior intracorneal ring segment, observing no significant difference in outcome between treatment arms. Steger et al (page 160) In vivo confocal microscopic findings in severe dry eye syndrome due to chronic ocular graft versus host disease include rarefication of the subbasal nerve plexus and dense accumulation of extracellular matrix in the anterior stroma. Reid et al (page 166...
Source: British Journal of Ophthalmology - January 20, 2015 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

Correction
Hajari JN, Kyhnel A, Bech-Azeddine J, et al. Progression of foveola-on rhegmatogenous retinal detachment. Br J Ophthalmol 2014;98:1534–1538. In figure 3 it is indicated in the first column that 1 percent of cases progress. This is wrong. It should state that 4 percent progress. The column wrongfully indicates the number of cases that progress instead of the percentage of cases. Please see below for correct figure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Tags: Corrections Source Type: research

Comparative histology of orbital, hepatic and subcutaneous cavernous venous malformations
We examined four representative, consecutive cases with a pathological diagnosis of cavernous malformation found in the liver, skin and orbit, respectively. A total of 12 cases were reviewed. All slides were stained as previously described.3 Morphological analysis revealed flat, mature vascular endothelium staining uniformly for CD31 without elastic lamina in all specimens. Vascular spaces were arranged in a back-to-back fashion, giving all cases a classic cavernous malformation appearance (figure 1A–C). Hepatic lesions tended to have minimal stroma, with... (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Rootman, D. B., Rootman, J., White, V. A. Tags: Letters Source Type: research

Ciliary neurotrophic factor (CNTF)-mediated ganglion cell survival in a rodent model of non-arteritic anterior ischaemic optic neuropathy (NAION)
Conclusions CNTF exerts a neuroprotective effect in ischaemic optic nerve injury and promotes RGC survival, suggesting that CNTF may be effective in the clinical treatment of human NAION. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Mathews, M. K., Guo, Y., Langenberg, P., Bernstein, S. L. Tags: Optic nerve, Neurology Original articles - Laboratory science Source Type: research

Toll-like receptor 3 activation drives the inflammatory response in oxygen-induced retinopathy in rats
Conclusions Our results suggest that upregulation of the TLR3 signalling pathway is involved in the pro-inflammatory response in OIR rat retinas. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Cai, M., Zhang, X., Li, Y., Xu, H. Tags: Retina, Vision, Neurology Original articles - Laboratory science Source Type: research

Assessment of laser induction of Bruch's membrane disruption in monkey by spectral-domain optical coherence tomography
Conclusions The presence of subretinal bubbles with haemorrhage is not an accurate indicator for successful disruption of the Bruch's membrane. Instead, spectral-domain OCT provides a better alternative to assess the retinal damages to the Bruch's membrane during laser induction of choroidal neovascularisation in monkeys. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Wang, Q., Lin, X., Xiang, W., Xiao, W., He, M. Tags: Ophthalmologic surgical procedures, Choroid, Retina Original articles - Laboratory science Source Type: research

A comparison of methods used to evaluate mobility performance in the visually impaired
Conclusions A validated scoring system based on errors is more effective when assessing visual disability during mobility testing than recording the time taken for course completion. The combined metric of ADREV errors noted divided by time taken was most predictive of all the methods used to evaluate visual disability during mobility testing. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Warrian, K. J., Katz, L. J., Myers, J. S., Moster, M. R., Pro, M. J., Wizov, S. S., Spaeth, G. L. Tags: Angle, Intraocular pressure, Retina, Glaucoma Original articles - Clinical science Source Type: research

Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen's disease: a tear proteomic study
Conclusions In moderate to severe dry eye in Hansen's disease, serum therapy in comparison with AT drops, improves clinical parameters and causes betterment in tear protein profile. Trial registration number CTRI/2013/07/003802. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Mukhopadhyay, S., Sen, S., Datta, H. Tags: Original articles - Clinical science Source Type: research

Infectious involvement in a tertiary center pediatric uveitis cohort
Conclusions An infectious cause of uveitis was identified in 17% of children with uveitis. T gondii and VZV were the most prevalent pathogens. We recommend analysing the aqueous humour of every child with vision-threatening uveitis of undetermined origin. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Hettinga, Y. M., de Groot-Mijnes, J. D. F., Rothova, A., de Boer, J. H. Tags: Epidemiology Original articles - Clinical science Source Type: research

Cystoid macular oedema following Descemet membrane endothelial keratoplasty
Conclusions CMO is a frequent complication following DMEK in phacic and pseudophacic eyes. The prognosis is excellent given medical treatment. We recommend regular SD-OCT monitoring during the first 6 months following DMEK. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Heinzelmann, S., Maier, P., Bohringer, D., Huther, S., Eberwein, P., Reinhard, T. Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Lens and zonules, Ocular surface Original articles - Clinical science Source Type: research

Efficacy and safety of intravitreal aflibercept injection in wet age-related macular degeneration: outcomes in the Japanese subgroup of the VIEW 2 study
Conclusions IVT-AFL was effective and well tolerated in Japanese patients. Outcomes in this population were consistent with those in the overall VIEW 2 population. Trial registration number NCT00637377. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Ogura, Y., Terasaki, H., Gomi, F., Yuzawa, M., Iida, T., Honda, M., Nishijo, K., Sowade, O., Komori, T., Schmidt-Erfurth, U., Simader, C., Chong, V., for the VIEW 2 Investigators Tags: Retina, Open access, Epidemiology Original articles - Clinical science Source Type: research

Mycophenolic acid in the treatment of birdshot chorioretinopathy: long-term follow-up
Conclusions Derivatives of mycophenolic acid are effective and safe drugs for the treatment of BSCR. In cases with gastrointestinal side effects, a therapy switch from MMF to MPS should be considered. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Doycheva, D., Jagle, H., Zierhut, M., Deuter, C., Blumenstock, G., Schiefer, U., Stingl, K., Januschowski, K., Voykov, B., Stuebiger, N. Tags: Original articles - Clinical science Source Type: research

Evaluation of iris and iridociliary body lesions with anterior segment optical coherence tomography versus ultrasound B-scan
Conclusions AS-OCT is superior to USB for imaging small lesions pertaining to the anterior iris but USB is better for imaging larger iris lesions with posterior or ciliary body extension. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Hau, S. C., Papastefanou, V., Shah, S., Sagoo, M. S., Restori, M., Cohen, V. Tags: Open access Original articles - Clinical science Source Type: research

Brilliant blue G assisted macular surgery: the effect of air infusion on contrast recognisability in internal limiting membrane peeling
Conclusions BBG under air infusion yields a significantly higher contrast staining and easy peeling of ILM associated with anatomical and functional improvement and no retinal toxicity after macular surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Totan, Y., Guler, E., Gurağac, F. B., Uzun, E., Doğdu, E. Tags: Lens and zonules, Retina Original articles - Clinical science Source Type: research

The effect of myopic optic disc tilt on measurement of spectral-domain optical coherence tomography parameters
Conclusions The diagnostic capacities of temporal RNFL thickness and vertical CDR should be interpreted with caution in glaucomatous eyes with tilted optic discs. Macular GCIPL measurement provides reliable diagnostic parameters, regardless of the degree of optic disc tilt. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Shin, H.-Y., Park, H.-Y. L., Park, C. K. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Prevalence of diabetic retinopathy within a national diabetic retinopathy screening service
Conclusions Prevalence of DR within the largest reported community-based, quality assured, DR screening programme, was higher in persons with type 1 diabetes; however, the major burden is represented by type 2 diabetes which is 94% of the screened population. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Thomas, R. L., Dunstan, F. D., Luzio, S. D., Chowdhury, S. R., North, R. V., Hale, S. L., Gibbins, R. L., Owens, D. R. Tags: Retina, Pupil, Epidemiology Original articles - Clinical science Source Type: research

Amniotic membrane graft to conjunctival flap in treatment of non-viral resistant infectious keratitis: a randomised clinical study
Conclusions CF and AMG are effective in treatment-resistant infectious keratitis. They could restore ocular surface integrity and provide metabolic and mechanical support for corneal healing. For large corneal perforation, it may be better to use another procedure such as penetrating keratoplasty to restore ocular integrity. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Abdulhalim, B.-E. H., Wagih, M. M., Gad, A. A. M., Boghdadi, G., Nagy, R. R. S. Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study
Conclusions CMV endotheliitis is most common in middle-aged and elderly men. CMV endotheliitis should be suspected when patients present with corneal endotheliitis involving coin-shaped lesions accompanied by anterior uveitis and ocular hypertension. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Koizumi, N., Inatomi, T., Suzuki, T., Shiraishi, A., Ohashi, Y., Kandori, M., Miyazaki, D., Inoue, Y., Soma, T., Nishida, K., Takase, H., Sugita, S., Mochizuki, M., Kinoshita, S., for the Japan Corneal Endotheliitis Study Group Tags: Public health, Angle, Choroid, Intraocular pressure, Open access Original articles - Clinical science Source Type: research

Cyclotorsional and non-cyclotorsional components of eye rotation observed from sitting to supine position
This study demonstrates that most of the rotations previously attributed to torsional components were probably due to NCYs, such as postural misalignments. Apparently, the amplitude of cyclotorsional movements is smaller than observed in previous reports, and could not be associated with any studied variable. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Prickett, A. L., Bui, K., Hallak, J., Bakhtiyari, P., de la Cruz, J., Azar, D. T., Chamon, W. Tags: Original articles - Clinical science Source Type: research

Predicting proliferative vitreoretinopathy: temporal and external validation of models based on genetic and clinical variables
Conclusions Genetic profiling of patients with RRD can improve the predictability of PVR in addition to the well-known clinical biomarkers. This validated formula could be a new tool in our current clinical practice in order to identify those patients at high risk of developing PVR. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Rojas, J., Fernandez, I., Pastor, J. C., MacLaren, R. E., Ramkissoon, Y., Harsum, S., Charteris, D. G., Van Meurs, J. C., Amarakoon, S., Garcia-Arumi, J., Ruiz-Moreno, J. M., Rocha-Sousa, A., Brion, M., Carracedo, A., for the Genetics on PVR Study Group ( Tags: Retina, Vitreous Original articles - Clinical science Source Type: research

Silicone band loop myopexy in the treatment of myopic strabismus fixus: surgical outcome of a novel modification
Conclusions Modified scleral fixated silicone band loop myopexy with or without MR recession is a safe and effective procedure in the management of MSF and improves alignment significantly. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Shenoy, B. H., Sachdeva, V., Kekunnaya, R. Tags: Muscles, Neurology Original articles - Clinical science Source Type: research

En-face high-penetration optical coherence tomography imaging in polypoidal choroidal vasculopathy
Conclusions HP-OCT can visualise choroidal vascular abnormalities in eyes with PCV and should be useful for understanding the pathogenesis of these abnormalities. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Sayanagi, K., Gomi, F., Akiba, M., Sawa, M., Hara, C., Nishida, K. Tags: Choroid Original articles - Clinical science Source Type: research

Granular corneal dystrophy type 2 is associated with morphological abnormalities of meibomian glands
Conclusions In GCD2, corneal deposits, and also morphological abnormalities of meibomian glands, such as obstruction or shortening, were found. Since abnormal phospholipid deposition is noted in GCD2, these results are interesting because phospholipid is possibly secreted from the meibomian gland. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Sakimoto, T. Tags: Original articles - Clinical science Source Type: research