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First clinical results on the feasibility, quality and reproducibility of aberrometry-based intraoperative refraction during cataract surgery
Conclusions This is the first report addressing quality and reproducibility of WA in a large sample. IWA refraction in aphakia, for instance, appears to be reliable once stable and pressurised anterior chamber conditions are achieved. More efforts are required to improve the precision and quality of measurements before IWA can be used to guide the surgical refractive plan in cataract surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Huelle, J. O., Katz, T., Druchkiv, V., Pahlitzsch, M., Steinberg, J., Richard, G., Linke, S. J. Tags: Lens and zonules Original articles - Clinical science Source Type: research

Correction
Pradeep A, Proudlock FA, Awan M, Bush G, Collier J, Gottlob I. An educational intervention to improve adherence to high-dosage patching regimen for amblyopia: a randomised controlled trial. Br J Ophthalmol 2014;98:865–870. The authors of this article should have acknowledged Huib Simonsz and colleagues from Rotterdam who designed and manufactured an occlusion-dose monitor (ODM) prior to the monitor discussed in this study. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Tags: Corrections Source Type: research

Lamina cribrosa displacement after optic nerve sheath fenestration in idiopathic intracranial hypertension: a new tool for monitoring changes in intracranial pressure?
Introduction Imaging in patients with idiopathic intracranial hypertension (IIH) is by definition normal but MRI may show dilatation of the subarachnoid space (SAS) around the optic nerve and a secondary flattening of the posterior sclera.1 Because of the existence of a trans-lamina cribrosa (LC) gradient, in patients with IIH the disc surface and thus the LC should be anteriorly displaced secondary to the raised intracranial pressure (ICP). In patients with glaucoma, an anterior displacement of the LC after lowering intraocular pressure (IOP) using spectral domain optical coherence tomography (SD-OCT) has been recently de...
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Perez-Lopez, M., Ting, D. S. J., Clarke, L. Tags: Letters Source Type: research

Masquerade ectasia
A 41-year-old otherwise healthy Pakistani male presented to our Cornea Clinic. He gave a history of bilateral, gradual, childhood onset myopia for which he used soft contact lenses (CL) daily for 20 years until 2009. Then, due to increasing astigmatism, he switched to rigid gas permeable (RGP) CLs. Because he experienced increasing discomfort after a year of using RGPs, his CL specialist tried several other CL options over the following 2 years, including mini-scleral and ‘piggy back’ lenses with little success. On examination, his right eye Log MAR corrected visual acuity with glasses was 0.58, best ...
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Dhillon, V. K., Elalfy, M. S., Albert, R., Shah, P. A., Mahmood, K., Dua, H. S. Tags: Cornea, Ocular surface, Optic nerve, Optics and refraction Education Source Type: research

Modified big-bubble deep anterior lamellar keratoplasty using peripheral air injection
Conclusions Air injection peripheral to the trephination site is a reproducible modification to the standard technique which can decrease the risk of DM perforation during air injection. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Feizi, S., Faramarzi, A., Javadi, M. A., Jafarinasab, M. R. Tags: Ophthalmologic surgical procedures Original articles - Laboratory science Source Type: research

CFI-rs7356506 is a genetic protective factor for acute anterior uveitis in Chinese patients
Conclusions This study has revealed a significant association between AAU and CFI-rs7356506, suggesting that CFI is involved in the pathogenesis of AAU, and that its influence on AAU may differ depending on gender and HLA-B27 status. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Wang, Y., Huang, X.-F., Yang, M.-M., Cai, W.-J., Zheng, M.-Q., Mao, G., Pang, C.-P., Jin, Z.-B. Tags: Choroid, Epidemiology Original articles - Laboratory science Source Type: research

Visualisation of contrast-enhanced intraoperative optical coherence tomography with indocyanine green
In this report, we describe the OCT features and contrast enhancement noted with indocyanine green using iOCT in human subjects as well as an ex vivo analysis in porcine eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Ehlers, J. P., McNutt, S., Dar, S., Tao, Y. K., Srivastava, S. K. Tags: Innovations Source Type: research

A new method using xenogeneicacellular dermal matrix in the reconstruction of lacrimal drainage
Conclusions The newly reconstructed lacrimal duct, formed by the shift of autogenous conjunctival petal and the attachment of acellular dermal matrix, was successful in all five cases and suggests a new solution for the complex lacrimal duct lesion and congenital anomalies of the lacrimal duct. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Chen, L., Gong, B., Wu, Z., Jetton, J., Chen, R., Qu, C. Tags: Lacrimal gland, Tears, Open access Original articles - Clinical science Source Type: research

Comparison of surgical outcomes between simple posterior layer advancement of lower eyelid retractors and combination with a lateral tarsal strip procedure for involutional entropion in a Japanese population
Conclusions The combination surgery in Group C and simple posterior layer advancement of the LER in Group B provided complete surgical success. The present study suggests the importance of preoperative evaluation of horizontal laxity, allowing surgeons to perform the least amount of surgery to achieve success. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Lee, H., Takahashi, Y., Ichinose, A., Kakizaki, H. Tags: Eye Lids Original articles - Clinical science Source Type: research

Orbital cellulitis in Scotland: current incidence, aetiology, management and outcomes
This study was a 1-year prospective observational study using the Scottish Ophthalmic Surveillance Unit reporting system among Scottish ophthalmologists. Results The response rate from ophthalmologists was 66.4%. There were 15 children and 5 adults reported giving an incidence of 1.6 per 100 000 and 0.1 per 100 000 in children and adults, respectively. 47% of children had a preceding upper respiratory tract infection with 87% having radiological evidence of sinus disease. Within the adult group, there was preceding immunosuppression and trauma. Streptococcus (66%) and Haemophilus (46%) species were the most comm...
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Murphy, C., Livingstone, I., Foot, B., Murgatroyd, H., MacEwen, C. J. Tags: Paediatrics, Epidemiology Original articles - Clinical science Source Type: research

Efficacy of diagnostic monocular occlusion in revealing the maximum angle of exodeviation
Conclusions Diagnostic monocular occlusion could be useful in patients with DE-type or CI-type exotropia and with hyperopia. In other cases, however, it has a limited role in determining the maximum angle of exodeviation compared with multiple examinations. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Han, J. M., Yang, H. K., Hwang, J.-M. Tags: Public health, Muscles, Optic nerve, Neurology, Optics and refraction Original articles - Clinical science Source Type: research

Weight at first detection of retinopathy of prematurity predicts disease severity
Conclusions Low weight and low WSDS at first ROP detection can be useful predictors for ROP warranting treatment. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Lundgren, P., Wilde, A., Lofqvist, C., Smith, L. E. H., Hard, A.-L., Hellstrom, A. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Validity and reliability of head posture measurement using Microsoft Kinect
Conclusions The KHT showed good agreement with the CROM and relatively favourable test–retest reliability. Considering its high performance, convenience and low cost, KHT could be clinically used as a head posture-measuring system. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Oh, B.-L., Kim, J., Kim, J., Hwang, J.-M., Lee, J. Tags: Original articles - Clinical science Source Type: research

Disc haemorrhage is associated with the fast component, but not the slow component, of visual field decay rate in glaucoma
Conclusions The presence of DH is associated with a greater fast component rate of VF decay. The identification and monitoring of the fast component of VF decay may prove useful in the identification and management of glaucoma patients at high risk of progression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Kim, J. M., Kyung, H., Azarbod, P., Lee, J. M., Caprioli, J. Tags: Angle, Intraocular pressure, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow
Discussion OAG patients of AD may have a stronger vascular component to their glaucoma pathophysiology than patients of ED. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Kanakamedala, P., Harris, A., Siesky, B., Tyring, A., Muchnik, M., Eckert, G., Abrams Tobe, L. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Combined endoscopic vitrectomy with pars plana tube shunt procedure
Conclusions Endoscopic vitrectomy with pars plana glaucoma tube shunt implantation may be considered in the management of uncontrolled IOP in patients with media opacity. Achieving IOP control prior to attempted anterior segment reconstruction in these severely diseased eyes may increase the success rate and decrease the complexity of subsequent anterior reconstruction procedures. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Shaikh, A. H., Khatana, A. K., Zink, J. M., Miller, D. M., Petersen, M. R., Correa, Z. M., Riemann, C. D. Tags: Ophthalmologic surgical procedures, Angle, Eye (globe), Intraocular pressure, Iris, Glaucoma Original articles - Clinical science Source Type: research

Effect of pegaptanib sodium 0.3 mg intravitreal injections (Macugen) in intraocular pressure: posthoc analysis from V.I.S.I.O.N. study
Conclusions In V.I.S.I.O.N., after 2 years, there was no evidence of sustained IOP elevation associated with pegaptanib 0.3 mg use. Trial registration number NCT00321997. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Boyer, D. S., Goldbaum, M., Leys, A. M., Starita, C., for the V.I.S.I.O.N. Study Group, Blumenkranz, Buyse, Goldberg, Gragoudas, Miller, Schwartz, Singerman, Yannuzzi, Adamis, Guyer, O'Shaughnessy, Buyse, de Gronckel, Fesneau, Quinaux, Tremolet, Wang, Bra Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Small incision iris tumour biopsy using a cavernous sampling forceps
Conclusions Iris tumour biopsies can be successfully approached using a cavernous 23G intraocular forceps with a low risk for procedure-related complications. The conical interior design allows for removal of whole tissue pieces with minimal manipulative artefacts. An optional bimanual access through a second corneal incision and use of a 23G scissors provides better efficacy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Chronopoulos, A., Kilic, E., Joussen, A. M., Lipski, A. Tags: Eye (globe), Pupil, Neurology Original articles - Clinical science Source Type: research

Progression of foveola-on rhegmatogenous retinal detachment
Conclusions The risk of progression of a foveola-on RRD to affect the fovea is small the first night of admission (1%). The amount of time surgery is delayed was found as significant risk factor for progression towards foveola. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Hajari, J. N., Kyhnel, A., Bech-Azeddine, J., la Cour, M., Kiilgaard, J. F. Tags: Retina Original articles - Clinical science Source Type: research

A novel classification of the vascular patterns of polypoidal choroidal vasculopathy and its relation to clinical outcomes
Conclusions The PCV subtype seen on initial presentation affects the long-term visual outcomes over a 5-year period. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Tan, C. S., Ngo, W. K., Lim, L. W., Lim, T. H. Tags: Choroid Original articles - Clinical science Source Type: research

Appearance of medium-large drusen and reticular pseudodrusen on adaptive optics in age-related macular degeneration
Conclusions AO allows differences in reflectivity between medium–large drusen and reticular pseudodrusen to be appreciated. The cone mosaics may be detected as continuous ‘bright’ hyper-reflective dots overlying/on the border of drusen and pseudodrusen deposits, and possibly as continuous ‘dark’ hyporeflective dots overlying drusen only. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Querques, G., Kamami-Levy, C., Blanco-Garavito, R., Georges, A., Pedinielli, A., Capuano, V., Poulon, F., Souied, E. H. Tags: Retina Original articles - Clinical science Source Type: research

Phenotype and genotype analysis in patients with macular corneal dystrophy
Conclusions Genetic mutation heterogeneity was revealed. No phenotype heterogeneity was revealed among patients with in vivo corneal morphology assessment or histological analysis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Nowinska, A. K., Wylegala, E., Teper, S., Wroblewska-Czajka, E., Aragona, P., Roszkowska, A. M., Micali, A., Pisani, A., Puzzolo, D. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behcet's disease
Conclusions This study indicates that measurement of subfoveal choroidal thickness by EDI-OCT is useful for evaluating the activity of uveitis and the therapeutic efficacy in patients with BD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Ishikawa, S., Taguchi, M., Muraoka, T., Sakurai, Y., Kanda, T., Takeuchi, M. Tags: Original articles - Clinical science Source Type: research

Treatment with immunosuppressive therapy in patients with pars planitis: experience of a reference centre in Mexico
Conclusions Immunosuppressive therapy allows an adequate control of inflammatory disease in pars planitis, with clinical and visual improvement and steroid dose reduction. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Serna-Ojeda, J. C., Pedroza-Seres, M. Tags: Choroid, Ciliary body Original articles - Clinical science Source Type: research

Postoperative endophthalmitis due to Burkholderia cepacia complex from contaminated anaesthetic eye drops
Conclusions Microbiology culture and BOX-PCR results revealed contamination of local anaesthetic eye drops and the same organism was cultured from a group of patients with acute-onset postoperative endophthalmitis after an uneventful cataract surgery. Outbreaks may occur in the most vigilant settings, and any sterile consumable may be a common link. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Lalitha, P., Das, M., Purva, P. S., Karpagam, R., Geetha, M., Lakshmi Priya, J., Naresh Babu, K. Tags: Ophthalmologic surgical procedures, Choroid, Eye (globe), Lens and zonules Original articles - Clinical science Source Type: research

Microbiological isolates and antibiotic sensitivities in culture-proven endophthalmitis: a 15-year review
Conclusions The microbiological spectrum and antibiotic sensitivities of endophthalmitis cases in Queensland, Australia, is similar to the spectrum of organisms causing endophthalmitis in other parts of Australia, North America and Europe. Empirical intravitreal vancomycin, ceftazidime and voriconazole are the most appropriate empirical antibiotics for suspected infective endophthalmitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Moloney, T. P., Park, J. Tags: Choroid, Eye (globe) Original articles - Clinical science Source Type: research

First clinicial results on the feasibility, quality and reproducibility of aberrometry-based intraoperative refraction during cataract surgery
Conclusions This is the first report addressing quality and reproducibility of WA in a large sample. IWA refraction in aphakia, for instance, appears to be reliable once stable and pressurised anterior chamber conditions are achieved. More efforts are required to improve the precision and quality of measurements before IWA can be used to guide the surgical refractive plan in cataract surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Huelle, J. O., Katz, T., Druchkiv, V., Pahlitzsch, M., Steinberg, J., Richard, G., Linke, S. J. Tags: Lens and zonules Original articles - Clinical science Source Type: research

Optical quality assessment in normal and forme fruste keratoconus eyes with a double-pass system: a comparison and variability study
Conclusions OQAS has the potential to be a useful diagnostic tool in cases with early keratoconus. The repeatability of a double-pass (DP) system was good in normal as well as forme fruste keratoconus eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Ye, C., Ng, P. K.-F., Jhanji, V. Tags: Cornea, Ocular surface Original articles - Clinical science Source Type: research

Topical antibiotics for the management of bacterial keratitis: an evidence-based review of high quality randomised controlled trials
Conclusions Results of this review suggest no evidence of difference in comparative effectiveness between fluoroquinolones and aminoglycoside–cephalosporin treatment options in the management of BK. There were differences in safety profile, however. Fluoroquinolones decreased the risk of ocular discomfort and chemical conjunctivitis while ciprofloxacin increased the risk of white corneal precipitate compared with aminoglycoside–cephalosporin. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: McDonald, E. M., Ram, F. S. F., Patel, D. V., McGhee, C. N. J. Tags: Conjunctiva, Cornea, Ocular surface Review Source Type: research

Ophthalmic Statistics Note 4: analysing data from randomised controlled trials with baseline and follow-up measurements
Scenario In clinical trials, continuous outcomes, such as intraocular pressure and visual acuity, are often measured both before treatment (ie, at baseline) and after treatment. Having the baseline measurement allows us to account for the initial differences between patients, which may well have arisen by chance, when comparing the outcomes of alternative treatments. While randomisation provides a good basis for comparisons between treatments and lowers the probability of baseline imbalance, imbalances can occur simply due to the play of chance, particularly when modest numbers of patients are randomised. Whether or not ba...
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Nash, R., Bunce, C., Freemantle, N., Dore, C. J., Rogers, C. A., Cairns, Cipriani, Cook, Crabb, Cumberland, Czanner, Donachie, Elders, Garcia Finana, O'Leary, Patel, Prevost, Quartilho, Saunders, Sivasubramaniam, Skene, Stratton, Vasconcelos, Xing, Zhu, O Tags: Retina, Open access Editorials Source Type: research

Early diagnosis of keratoconus: what difference is it making?
In this study, the optimum cut-off point for posterior elevation was found to be 26.5 µm (97.7% sensitivity and 81.0% specificity). In a study by Mihaltz et al2, receiver operating characteristic (ROC) curve analysis indicated that posterior elevation was the... (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Fernandez Perez, J., Valero Marcos, A., Martinez Pena, F. J. Tags: Cornea, Ocular surface, Optic nerve, Open access, Optics and refraction, Epidemiology Editorials Source Type: research

Highlights from this issue
In this month's issue, Nash et al1 continue their series of Statistics notes on behalf of the Ophthalmic Statistics Group. In this article they discuss methods of analysing continuous variables of clinical trial data baseline and post-treatment. In a systematic review and meta-analysis of trials of topical antibiotics for bacterial keratitis using Cochrane methodlology, McDonald et al2 report no evidence of difference in comparative effectiveness between fluoroquinolones and aminoglycoside-cephalosporin combinations, although there they observed reported differences in the safety profile. Oh et al3 describe and validate th...
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

Re: Ang et al: Descemet's stripping automated endothelial keratoplasty with anterior chamber intraocular lenses: complications and 3-year outcomes
Dear editor, We read with interest the article titled ‘Descemet's stripping automated endothelial keratoplasty with anterior chamber intraocular lenses: complications and 3-year outcomes’ by Ang et al.1 Although the authors concluded that endothelial cell loss and graft survival in anterior chamber intraocular lens (ACIOL) group were significantly poorer compared with Descemet's stripping automated endothelial keratoplasty (DSAEK) controls at 3 years postoperatively, we would like to draw attention to following issues:Though the title of the article stated that it was a ‘3-year’ outcome study, ...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Mittal, R., Garg, P. Tags: Letters Source Type: research

Correction
Tang J, Herda AA, and Kern TS. Photobiomodulation in the treatment of patients with non-centerinvolving diabetic macular oedema. Br J Ophthalmol 2014;98:1013–5. The article states that the daily dose of light administered was 25 J/cm2; however the actual dose per treatment was 9 J/cm2. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Tags: Corrections Source Type: research

Descemet's stripping automated endothelial keratoplasty with anterior chamber intraocular lenses
Dear Editor, We thank Mittal and Garg for their interest in our publication. Our study analysed Descemet's stripping automated endothelial keratoplasty (DSAEK) with anterior chamber intraocular lenses (ACIOL) with regards to 3-year graft survival and endothelial cell loss as our main outcome measures, not visual outcome or complications.1 Here, we used Kaplan–Meier survival analysis that takes into account any censored data from loss to follow-up, to derive that there was a significantly poorer graft survival in the DSAEK-ACIOL group versus the DSAEK group (log-rank p=0.002). In fact, completely excluding subjects wi...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Tan, D., Htoon, H. M., Ang, M. Tags: Letters Source Type: research

Two novel mutations including a large deletion of the SLC4A11 gene causing autosomal recessive hereditary endothelial dystrophy
Introduction Congenital hereditary endothelial dystrophy (CHED) is an inherited disorder of the corneal endothelium characterised by bilateral non-inflammatory corneal clouding ranging from a diffuse haze to a ground-glass appearance. CHED can be inherited in an autosomal dominant (CHED1) or recessive (CHED2) manner. CHED2 usually presents at birth or early infancy. Bilateral corneal clouding can lead to visual impairment often accompanied by nystagmus in CHED2 patients requiring corneal transplantation.1 Mutations in the solute carrier family 4 member 11 (SLC4A11) gene have been identified in most patients with CHED2. Wit...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Puangsricharern, V., Yeetong, P., Charumalai, C., Suphapeetiporn, K., Shotelersuk, V. Tags: Letters Source Type: research

Novel mitochondrial tRNAIle m.4282A>G gene mutation leads to chronic progressive external ophthalmoplegia plus phenotype
Conclusions We describe a novel MTTI transition mutation at nucleotide position m.4282G>A associated with a CPEO plus phenotype. The novel variant at position m.4282G>A disrupts the middle bond of the D-stem of the tRNAIle and is highly conserved. The conservation and phenotype-genotype segregation strongly suggest pathogenicity and is in good agreement with the MTTI gene being frequently associated with CPEO. This novel variant broadens the spectrum of MTTI mutations causing CPEO. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Jackson, C. B., Neuwirth, C., Hahn, D., Nuoffer, J.-M., Frank, S., Gallati, S., Schaller, A. Tags: Muscles, Neurology Original articles - Laboratory science Source Type: research

Effects of aflibercept on primary RPE cells: toxicity, wound healing, uptake and phagocytosis
Conclusions Aflibercept interferes with the physiology of RPE cells, as it is taken up into RPE cells, which is accompanied by a reduction of the phagocytic ability. Additionally, it impairs the wound healing capacity of RPE cells. These effects on the physiology of RPE cells may indicate possible side effects. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Klettner, A., Tahmaz, N., Dithmer, M., Richert, E., Roider, J. Tags: Retina, Editor's choice Original articles - Laboratory science Source Type: research

Eyelash line resection for cilial entropion in patients with Down's syndrome
Conclusions Eyelash line resection is a simple and effective technique for cilial entropion and medial epiblepharon in patients with Down's syndrome. The surgery improves the SPK and frequency of spectacle wear. Trial registration number NCT01758718. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Suzuki, Y., Hama, Y., Yoshikawa-Kobayashi, I., Tomita, K., Inoue, M., Hirakata, A. Tags: Cornea, Eye Lids, Ocular surface, Neurology Original articles - Clinical science Source Type: research

Medial lower lid epiblepharon repair solely by skin-redraping medial epicanthoplasty
Conclusions For patients with medial lower lid epiblepharon with epicanthal fold without excessive skin and muscle, a simple skin-redraping medial epicanthoplasty without traditional epiblepharon correction methods showed good results of epiblepharon repair. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Oh, J., Lee, K. Tags: Original articles - Clinical science Source Type: research

Management of congenital lacrimal (anlage) fistula
Conclusions Congenital lacrimal fistulae may be successfully treated with simple excision alone in most cases. Adjunctive DCR or intubation can be reserved for those identified to have lacrimal outflow tract abnormalities. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Al-Salem, K., Gibson, A., Dolman, P. J. Tags: Ophthalmologic surgical procedures, Neurology Original articles - Clinical science Source Type: research

Clinical outcomes of sleeveless phacotip assisted levitation of dropped nucleus
Conclusion Dropped nucleus was successfully levitated into anterior chamber with this technique, resulting in a significant visual outcome with a favourable complication rate. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Agarwal, A., Narang, P., A Kumar, D., Agarwal, A. Tags: Cornea, Ocular surface, Retina Original articles - Clinical science Source Type: research

Results of late surgical intervention in children with early-onset bilateral cataracts
Conclusions and relevance Our results demonstrate that not only can significant vision be acquired until late in childhood, but that neural processes underlying even basic aspects of vision like resolution acuity remain malleable until at least adolescence. These data argue for the provision of cataract treatment to all children, irrespective of their age. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Ganesh, S., Arora, P., Sethi, S., Gandhi, T. K., Kalia, A., Chatterjee, G., Sinha, P. Tags: Paediatrics, Ophthalmologic surgical procedures, Lens and zonules, Vision, Neurology, Visual development Original articles - Clinical science Source Type: research

Traditional and reduced recession surgical dosage for bilateral lateral rectus recession for infantile exotropia
Conclusions Postoperative surgical outcome was not affected by a reduction in the amount of recession by 1–2 mm from traditional tables used for treatment of exotropia. Reducing the recession of the lateral recti reduces the risk of overcorrection in this sensory labile population. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Nam, K.-T., Kim, S.-H. Tags: Paediatrics, Muscles, Neurology Original articles - Clinical science Source Type: research

Factors associated with the angle of exodeviation in patients with recurrent exotropia
Conclusions Although the overall incidence of recurrent exotropia with a relatively large angle (LAAR≥PA) is low among patients who underwent surgery for exotropia (2.5%), the possibility of this phenomenon should be noted. The ratio of relatively large angle recurrence was higher in patients with a small preoperative exodeviation and basic type exotropia. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Lee, B. J., Kim, S.-J., Yu, Y. S. Tags: Muscles, Neurology Original articles - Clinical science Source Type: research

Comparison of different surgery procedures for convergence insufficiency-type intermittent exotropia in children
Conclusions The improved R&R procedure in which medial rectus resection based on the near deviation with lateral rectus recession based on the distant deviation has a better alignment than the UMR and BMR surgeries for the treatment of children with CI-type IXT. All the UMR, BMR and improved R&R surgery can reduce near-distance differences in children with CI-type IXT. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Wang, B., Wang, L., Wang, Q., Ren, M. Tags: Paediatrics, Muscles, Neurology Original articles - Clinical science Source Type: research

Lateral incomitancy and surgical results in intermittent exotropia
Conclusions Surgical outcomes in ULR and BLR for intermittent exotropia correction showed no association with preLI+. The prevalences of significant LI were unchanged after surgery in both groups. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Yoon, C. H., Kim, S.-J. Tags: Muscles, Neurology Original articles - Clinical science Source Type: research

The relationship between preoperative and postoperative near stereoacuities and surgical outcomes in intermittent exotropia
Conclusions Classification of IXT based on the degree of near stereopsis offers a useful tool for the assessment of initial sensory status as well as postoperative prognosis. Also, a lower age at first detection of IXT and a lower best-corrected visual acuity were associated with poor near stereoacuity. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Lee, D. S., Kim, S.-J., Yu, Y. S. Tags: Muscles, Neurology Original articles - Clinical science Source Type: research

Gaze and pupil changes during navigation in age-related macular degeneration
Conclusions Fixation count is a marker of difficult navigational environments in patients with AMD. The combination of video projection and eye tracking to assess visual navigation function is a useful clinical tool and an adjunct to current investigation tools in AMD intervention studies providing objective clinical measures under standardised settings. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Aspinall, P. A., Borooah, S., Al Alouch, C., Roe, J., Laude, A., Gupta, R., Gupta, M., Montarzino, A., Dhillon, B. Tags: Retina Original articles - Clinical science Source Type: research

Relationship between halo size and forward light scatter
Conclusions In healthy eyes, the larger the halo size induced by a given glare source, the greater the forward-scatter (straylight) and worse the mesopic LC-VA. Halo size seems to be independent of photopic HC-VA or LC-VA and mesopic HC-VA. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Puell, M. C., Perez-Carrasco, M. J., Palomo-Alvarez, C., Antona, B., Barrio, A. Tags: Original articles - Clinical science Source Type: research