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Correction: Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension
Lewis RA, Levy B, Ramirez N, et al. Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension. Br J Ophthalmol 2016;100:339–44. The trial registration number is listed as NCT02207491. That is the number for a different study of AR-13324. The correct number is NCT02057575. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Tags: Corrections Source Type: research

Correction: Effect of the pigment-free optical zone diameter of decorative tinted soft contact lenses on visual function
Jung JW, Kim SM, Han SH, et al. Effect of the pigment-free optical zone diameter of decorative tinted soft contact lenses on visual function. Br J Ophthalmol 2016;100:633–37. In the Funding statement, the grant number is incorrect. "Yonsei University College of Medicine for 2014 (6-2014-0036)." should read "Yonsei University College of Medicine for 2014 (6-2014-0159)." (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Tags: Corrections Source Type: research

Correction: Choroidal thickness in children with hyperopic anisometropic amblyopia
Nishi T, Ueda T, Hasegawa T, et al. Choroidal thickness in children with hyperopic anisometropic amblyopia. Br J Ophthalmol 2014;98:228–32. Figure 2A and 2B have been labelled the wrong way round in the Figure 2 caption. Figure 2A is the amblyopic eye and 2B is fellow eye. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Tags: Corrections Source Type: research

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas
Conclusions Chromosomal aberrations seen in posterior UM can also be demonstrated using MLPA or MSA in both treatment naïve and PBR-treated IM. Most IM display a low-metastatic risk chromosomal profile. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Krishna, Y., Kalirai, H., Thornton, S., Damato, B. E., Heimann, H., Coupland, S. E. Tags: Eye (globe), Epidemiology Original articles - Laboratory science Source Type: research

Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation
Conclusions Balancing proper healing and good vision is crucial in the cornea, constantly exposed to potential injuries. In this paper, we suggest the existence of a mechanism regulating the onset of inflammation (and associated CNV) depending on injury severity. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Ferrari, G., Giacomini, C., Bignami, F., Moi, D., Ranghetti, A., Doglioni, C., Naldini, L., Rama, P., Mazzieri, R. Tags: Cornea, Ocular surface Original articles - Laboratory science Source Type: research

Efficacy of dexamethasone versus bevacizumab on regression of hard exudates in diabetic maculopathy: data from the BEVORDEX randomised clinical trial
Conclusions Bevacizumab and DEX were effective in reducing area of HEX in eyes with DME. DEX provided more rapid regression of HEX from the foveal centre although bevacizumab-treated eyes started to catch up by 24 months. Distance from the foveal centre as well as total area of macular HEX should be assessed when evaluating treatments for foveal-threatening HEX. Trial registration number NCT01298076; Post-results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Mehta, H., Fraser-Bell, S., Yeung, A., Campain, A., Lim, L. L., Quin, G. J., McAllister, I. L., Keane, P. A., Gillies, M. C. Tags: Original articles - Clinical science Source Type: research

Comparison of macular choroidal thicknesses from swept source and spectral domain optical coherence tomography
Conclusions CT measurements between automated segmentations from the DRI OCT-1 and manual segmentations on the Spectralis OCT may differ by more than 50 µm. This difference can be reduced, but not eliminated, by manual adjustment of segmentation boundaries by trained graders, and should be accounted for when comparing results between the two devices. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Tan, C. S., Cheong, K. X., Lim, L. W., Sadda, S. R. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Behcet's disease ocular attack score 24 and visual outcome in patients with Behcet's disease
Conclusions BOS24-5Y was found to be a significant positive prognostic index for VA deterioration in patients with ocular Behcet's disease. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Tanaka, R., Murata, H., Takamoto, M., Ohtomo, K., Okinaga, K., Yoshida, A., Kawashima, H., Nakahara, H., Fujino, Y., Kaburaki, T. Tags: Choroid Original articles - Clinical science Source Type: research

The impact of donor age and endothelial cell density on graft survival following penetrating keratoplasty
Conclusions We were unable to detect a significant effect of donor age, up to 90 years, and preoperative donor ECD, above the lower limit of 2200 cells/mm2, on endothelial failure at 5 years following PK. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Wakefield, M. J., Armitage, W. J., Jones, M. N. A., Kaye, S. B., Larkin, D. F. P., Tole, D., Prydal, J., on behalf of the National Health Service Blood and Transplant Ocular Tissue Advisory Group (OTAG Audit Study 19) Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Evaluation of the efficacy and safety of a standardised intracameral combination of mydriatics and anaesthetics for cataract surgery
Conclusions Mydrane is an effective and safe alternative to standard eye drops for initiating and maintaining intraoperative mydriasis and analgesia. Patients who received IC Mydrane were significantly more comfortable before IOL insertion than the reference group. Surgeons found IOL insertion less technically challenging with IC Mydrane. Trial registration number NCT02101359; Results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Labetoulle, M., Findl, O., Malecaze, F., Alio, J., Cochener, B., Lobo, C., Lazreg, S., Hartani, D., Colin, J., Tassignon, M.-J., Behndig, A., on behalf of the Intracameral Mydrane Study 2 Group, on behalf of the Intracameral Mydrane Study 2 Group, Bonicel Tags: Ophthalmologic surgical procedures, Lens and zonules, Pupil, Open access Original articles - Clinical science Source Type: research

Efficacy of conjunctival resection with cyanoacrylate glue application in preventing recurrences of Mooren's ulcer
Conclusions Conjunctival resection and cyanoacrylate glue application are not effective in avoiding recurrences and halting the disease progression in cases of Mooren's ulcer. Systemic immunosuppression remains the mainstay of therapy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Lal, I., Shivanagari, S. B., Ali, M. H., Vazirani, J. Tags: Original articles - Clinical science Source Type: research

Influence of involuntary eyelid spasms on corneal topographic and eyelid morphometric changes in patients with hemifacial spasm
Conclusions The results suggest that treatment with BTX-A in patients with HFS leads to eyelid and corneal changes on the affected eye that are significant during the known period of action of the toxin. Thus, caution should be taken when performing ophthalmological examination in patients with HFS, since it may vary according to BTX-A period of action. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Osaki, T., Osaki, M. H., Osaki, T. H., Hirai, F. E., Nallasamy, N., Campos, M. Tags: Optic nerve, Neurology, Optics and refraction Original articles - Clinical science Source Type: research

Assessment of estimated retinal atrophy progression in Stargardt macular dystrophy using spectral-domain optical coherence tomography
Conclusions SD-OCT measurements allow monitoring the decline in retinal volume in STGD1; however, they require significant manual correction of software errors. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Strauss, R. W., Munoz, B., Wolfson, Y., Sophie, R., Fletcher, E., Bittencourt, M. G., Scholl, H. P. N. Tags: Retina, Open access Original articles - Clinical science Source Type: research

Triamcinolone during pars plana vitrectomy for open globe trauma: a pilot randomised controlled clinical trial
Conclusions An RCT in this population is deliverable and estimated recruitment rates are realistic. Results and patient discussions determined that the definitive study should have vision as a primary outcome. This pilot study is supportive of there being a positive treatment effect of intensive anti-inflammatory agents in OGT. Trial registration number European Clinical Trials Database 2007-005138-35; Results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Banerjee, P. J., Xing, W., Bunce, C., Woodcock, M., Chandra, A., Scott, R. A. H., Charteris, D. G. Tags: Ophthalmologic surgical procedures, Retina, Vitreous, Epidemiology Original articles - Clinical science Source Type: research

Treatment of partial limbal stem cell deficiency with topical interferon {alpha}-2b and retinoic acid
Conclusions Combination treatment of topical IFN α-2b and ATRA 0.01% can be considered in partial LSCD, where adjacent parts of the limbus remain intact. This treatment is associated with minimal side effects and no recurrence of signs of LSCD at least 18 months after clinical resolution. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Tan, J. C., Tat, L. T., Coroneo, M. T. Tags: Original articles - Clinical science Source Type: research

Corynebacterium spp as causative agents of microbial keratitis
Conclusions Corynebacteria can cause severe corneal infection requiring surgical intervention. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Das, S., Rao, A. S., Sahu, S. K., Sharma, S. Tags: Cornea, Eye (globe), Ocular surface, Editor's choice Original articles - Clinical science Source Type: research

Changes in corneal endothelial cell density and the cumulative risk of corneal decompensation after Ahmed glaucoma valve implantation
Conclusions In case of uncomplicated AGV implantation, the cumulative risk of corneal decompensation was 3.3%, 5 years after the operation. The ECD loss was statistically greater in eyes with AGV than in control eyes without AGV, but the difference was significant only up to 2 years post surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Kim, K. N., Lee, S. B., Lee, Y. H., Lee, J. J., Lim, H. B., Kim, C.-s. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Risk factors for low vision related functioning in the Mycotic Ulcer Treatment Trial: a randomised trial comparing natamycin with voriconazole
Conclusions Monocular vision loss from corneal opacity due to fungal keratitis reduced vision-related quality of life. Given the relatively high worldwide burden of corneal opacity, improving treatment outcomes of corneal infections should be a public health priority. Trial registration number Clinicaltrials.gov Identifier: NCT00996736. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Rose-Nussbaumer, J., Prajna, N. V., Krishnan, T., Mascarenhas, J., Rajaraman, R., Srinivasan, M., Raghavan, A., Oldenburg, C. E., O'Brien, K. S., Ray, K. J., Porco, T. C., McLeod, S. D., Acharya, N. R., Keenan, J. D., Lietman, T. M., for the Mycotic Ulcer Tags: Public health, Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface, Vision, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Ocular surface disease in patients with diabetic peripheral neuropathy
Conclusion This study demonstrates some increased clinical signs of ocular surface disease but not an increase in subjective symptoms of dry eyes, with increasing severity of DPN. Furthermore, no significant correlation was found between OSDI scores and clinical signs of dry eye. A periodic evaluation of the ocular surface is important for patients with DM, in addition to retinopathy screening, as they may be asymptomatic but have severe dry eye disease, which can lead to further ocular surface complications such as corneal ulceration. Trial registration number NCT01695629. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: DeMill, D. L., Hussain, M., Pop-Busui, R., Shtein, R. M. Tags: Cornea, Eye (globe), Ocular surface, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Prevalence and clinical correlates of focal choroidal excavation in eyes with age-related macular degeneration, polypoidal choroidal vasculopathy and central serous chorioretinopathy
Conclusions FCE is more common in PCV than AMD-CNV and CSC. Disturbance in the choroid/retinal pigment epithelium/Bruch membrane interface affected by FCE may be linked to the pathogenesis of PCV and AMD-CNV. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Lim, F. P. M., Wong, C. W., Loh, B. K., Chan, C. M., Yeo, I., Lee, S. Y., Mathur, R., Wong, D., Wong, T. Y., Cheung, C. M. G. Tags: Choroid, Retina Original articles - Clinical science Source Type: research

A systematic review of as needed versus treat and extend ranibizumab or bevacizumab treatment regimens for neovascular age-related macular degeneration
Conclusions Though our study suggests superiority of the treat and extend regimen to PRN treatment in a 12-month period, this review demonstrates the need for randomised clinical trials to confirm our findings and to evaluate long-term efficacy outcomes with these regimens compared with monthly therapy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Chin-Yee, D., Eck, T., Fowler, S., Hardi, A., Apte, R. S. Tags: Retina Original articles - Clinical science Source Type: research

Vascular risk factors and rhegmatogenous retinal detachment: a follow-up of a national cohort of Swedish men
Conclusions Vascular risk factors may be important determinants of RRD, particularly among non-myopics. Further investigations on the role of hypertension and obesity are needed. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Farioli, A., Hemmingsson, T., Kriebel, D. Tags: Public health, Optic nerve, Retina, Optics and refraction Original articles - Clinical science Source Type: research

Predicting complications with pretreatment testing in infantile haemangioma treated with oral propranolol
Conclusions The predictive values of both protocols for the commonly observed adverse reactions are low. In this series, there is no evidence to suggest that routine pretreatment testing before propranolol initiation is of any value in otherwise healthy children. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Tang, L. Y., Hing, J. W., Tang, J. Y., Nishikawa, H., Shahidullah, H., Browne, F., Chikermane, A., Parulekar, M. Tags: Paediatrics Original articles - Clinical science Source Type: research

Correlation between peripapillary retinal thickness and serum level of vascular endothelial growth factor in patients with POEMS syndrome
Conclusions The significant correlation between the pRT and the serum level of VEGF suggests that the higher serum level of VEGF might be associated with the development of the optic disc oedema in patients with POEMS syndrome. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Yokouchi, H., Baba, T., Misawa, S., Sawai, S., Kitahashi, M., Oshitari, T., Kuwabara, S., Yamamoto, S. Tags: Neurology Original articles - Clinical science Source Type: research

Analysis of peripapillary choroidal thickness in non-arteritic anterior ischaemic optic neuropathy
Conclusions Eyes affected by NAION and contralateral unaffected eyes showed significantly thinner PCT compared with disease-free control eyes after adjusting for refractive error. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Garcia-Basterra, I., Lahrach, I., Morillo Sanchez, M. J., Kamal-Salah, R., Rius-Diaz, F., Dawid Milner, M. S., Garcia-Campos, J. M. Tags: Optic nerve, Neurology, Optics and refraction Original articles - Clinical science Source Type: research

Global variations and time trends in the prevalence of childhood myopia, a systematic review and quantitative meta-analysis: implications for aetiology and early prevention
The aim of this review was to quantify the global variation in childhood myopia prevalence over time taking account of demographic and study design factors. A systematic review identified population-based surveys with estimates of childhood myopia prevalence published by February 2015. Multilevel binomial logistic regression of log odds of myopia was used to examine the association with age, gender, urban versus rural setting and survey year, among populations of different ethnic origins, adjusting for study design factors. 143 published articles (42 countries, 374 349 subjects aged 1–18 years, 74 847 ...
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Rudnicka, A. R., Kapetanakis, V. V., Wathern, A. K., Logan, N. S., Gilmartin, B., Whincup, P. H., Cook, D. G., Owen, C. G. Tags: Optic nerve, Open access, Optics and refraction, Epidemiology Review Source Type: research

Computer-aided design and three-dimensional printing in the manufacturing of an ocular prosthesis
Restoring the facial appearance in acquired anophthalmos entails precision fitting of a customised ocular prosthesis. The fabrication is an artisanal process, and is primarily based on an impression of the anophthalmic cavity. This is usually achieved by the impression-moulding method, which, however, may introduce errors, resulting in a poorly fitted prosthesis. We developed a new method in the manufacturing of a customised ocular prosthesis based on computer-aided design and computer-aided manufacturing. An ocular prosthesis, based on a three-dimensional (3D) printed impression-free mould of the anophthalmic cavity, was ...
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Ruiters, S., Sun, Y., de Jong, S., Politis, C., Mombaerts, I. Tags: Eye (globe) Innovations Source Type: research

Ophthalmic statistics note 9: parametric versus non-parametric methods for data analysis
Introduction/scenario Distributions of measured data are often well modelled by known probability distributions, which provide a useful description of their underlying properties such as location (average), spread (variation) and shape. Statisticians use probability distributions to interpret and attribute meaning, draw conclusions and answer research questions using the measurements or data that researchers gather during their studies. Different types of data follow different probability distributions, and these distributions are characterised by certain features called parameters. Even the most statistically averse of re...
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Skene, S. S., Bunce, C., Freemantle, N., Dore, C. J., On behalf of the Ophthalmic Statistics Group, On behalf of the Ophthalmic Statistics Group, Cipriani, Cook, Crabb, Cumberland, Czanner, Donachie, Elders, Finana, Nash, Quartilho, Rogers, Saunders, Step Tags: Choroid, Eye (globe), Orbit Editorials Source Type: research

Highlights from this issue
A-Basterra et al (see page 891) Eyes affected by nonarteritic anterior ischemic optic neuropathy and their contralateral unaffected eyes show thinner peripapillary choroidal thickness than healthy eyes. A thin peripapillary choroid may be added to the features of this disease. Yokouchi et al (see page 897) The higher serum VEGF level might be associated with the development of optic disc oedema in patients with POEMS syndrome. Parulekar et al (see page 902) Evidence indicates that there is no value in pre-treatment testing of infantile haemangioma with oral propranolol. Farioli et al (see page 907) Obesity and high blood p...
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Barton, K., Jonas, J., Chodosh, J. Tags: At a glance Source Type: research

Developing transcutaneous nanoenabled anaesthetics for eyelid surgery
In this study, we explore the feasibility of nanoenabled lidocaine delivery across an artificial skin analogue. Materials and methods Three different lidocaine-loaded nanocarriers were characterised. Diffusion studies were performed through cellulose membranes using customised Franz cells. The nanocarriers included polymeric micelles (PMs) (Soluplus), solid lipid nanoparticles (SLNs) (Tripalmitin: Lecithin: Labrasol: polysorbate-20: water; 3.33:1:40:1:4.67 w/w) and self-nanoemulsifying drug delivery systems (SNEDDS) (Capryol-90: Transcutol: Labrasol; 1:3:6 w/w). Particles were characterised in terms of size, zeta-potentia...
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Lalatsa, A., Emeriewen, K., Protopsalti, V., Skelton, G., Saleh, G. M. Tags: Original articles - Laboratory science Source Type: research

CADS grading scale: towards better grading of ophthalmic involvement in facial nerve paralysis
Conclusions We present a validation study of an FNGI specifically designed for ophthalmic involvement of FNP. Objective and subjective parameters helped standardise grading and management planning. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Malhotra, R., Ziahosseini, K., Litwin, A., Nduka, C., El-Shammah, N. Tags: Neurology Original articles - Clinical science Source Type: research

Exposure rate of unwrapped hydroxyapatite orbital implants in enucleation surgery
Conclusions The placement of an unwrapped HA orbital implant with rectus end-to-end suturing in enucleation surgery was associated with a low rate of exposure in most cases. The end-to-end suturing creates a joint-like structure over the HA sphere, protecting the Tenon's capsule and conjunctiva from its rough surface and reducing the risk of implant exposure. Prior ocular surgery may be another risk factor for HA exposure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Ye, J., Gao, Q., He, J.-j., Gao, T., Ning, Q.-y., Xie, J.-j. Tags: Original articles - Clinical science Source Type: research

Interobserver agreement using Goldmann applanation tonometry and dynamic contour tonometry: comparing ophthalmologists, nurses and technicians
Discussion/conclusions Ophthalmologists show good levels of agreement with each other when using GAT, while technicians/nursing staff show better agreement when using the DCT. The DCT may be a better tonometer to use if permanently delegating IOP measurements to non-ophthalmologists, but measurements cannot be interchanged with the GAT. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Kotecha, A., Elkarmouty, A., Ajtony, C., Barton, K. Tags: Public health, Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Applanation tonometry: interobserver and prism agreement using the reusable Goldmann applanation prism and the Tonosafe disposable prism
Conclusions There is an acceptable agreement between IOP measurements made with the reusable Goldmann tonometer prism and the disposable Tonosafe prism. Interobserver variability in IOP measurements within an outpatient setting is larger than that found within a research setting, and may be of a level that impacts on clinical decision-making. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Ajtony, C., Elkarmouty, A., Barton, K., Kotecha, A. Tags: Public health Original articles - Clinical science Source Type: research

EP3/FP dual receptor agonist ONO-9054 administered morning or evening to patients with open-angle glaucoma or ocular hypertension: results of a randomised crossover study
Conclusions PM dosing of ONO-0954 was associated with a slightly increased frequency of mild hyperaemia and mild to moderate dryness. Both dosing schedules provided sustained reduction in IOP. Trial registration number NCT01670266. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Berlin, M. S., Rowe-Rendleman, C., Ahmed, I., Ross, D. T., Fujii, A., Ouchi, T., Quach, C., Wood, A., Ward, C. L. Tags: Angle, Intraocular pressure, Open access, Glaucoma Original articles - Clinical science Source Type: research

Incidence and survival of retinoblastoma in Taiwan: a nationwide population-based study 1998-2011
Conclusions The incidence of retinoblastoma in Taiwan exhibited no marked trend over time. There were more cases of males than females and the male-to-female rate ratio increased with age. Survival outcome was significantly associated with the intervention of enucleation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Li, S.-Y., Chen, S. C.-C., Tsai, C.-F., Sheu, S.-M., Yeh, J.-J., Tsai, C.-B. Tags: Open access, Epidemiology Original articles - Clinical science Source Type: research

Retinopathy of prematurity in Korean infants with birthweight greater than 1500 g
Conclusion Our study confirmed that treatment-requiring ROP does occur in infants with BW >1500 g. To avoid overlooking infants with vision-threatening ROP, an evaluation of the data from larger BW preterm infants is advisable so that screening guidelines in neonatal care units may be refined. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Park, S. H., Yum, H. R., Kim, S., Lee, Y. C. Tags: Paediatrics, Ophthalmologic surgical procedures, Retina, Epidemiology Original articles - Clinical science Source Type: research

The ophthalmic phenotype of IFT140-related ciliopathy ranges from isolated to syndromic congenital retinal dystrophy
Conclusions Recessive IFT140 mutations cause a severe congenital retinal dystrophy with high hyperopia and often early photophilia. Developmental delay is common but not universal and not all patients have obvious extraocular findings. The c.1990G>A mutation represents a founder effect or mutational hotspot on the Arabian Peninsula. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Bifari, I. N., Elkhamary, S. M., Bolz, H. J., Khan, A. O. Tags: Paediatrics, Optic nerve, Optics and refraction Original articles - Clinical science Source Type: research

Novel morphological macular findings in juvenile CLN3 disease
Conclusions This study represents the first prospective observational case series documenting retinal abnormalities in CLN3 disease with the aid of the spectral domain optical coherence tomography. The major finding was a characteristic, striated macular pattern in all patients studied. Particularly in early disease cases, macular striae can potentially help to discriminate CLN3 disease from other inherited forms of retinitis pigmentosa. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Dulz, S., Wagenfeld, L., Nickel, M., Richard, G., Schwartz, R., Bartsch, U., Kohlschütter, A., Schulz, A. Tags: Eye (globe), Retina, Neurology Original articles - Clinical science Source Type: research

Outer retinal tubulations response to anti-VEGF treatment
Conclusions ORTs documented by SD-OCT may exhibit multiple types of longitudinal changes, such as collapse, recurrence or enlargement, which could be associated with anti-VEGF treatment or spontaneous. Some ORTs may have a vascular component or may be vascular in nature, considering their response to anti-VEGF treatment, while other ORTs are likely composed only of degenerating photoreceptor cells and may collapse independently from anti-VEGF treatments. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Espina, M., Arcinue, C. A., Ma, F., Camacho, N., Barteselli, G., Mendoza, N., Ferrara, N., Freeman, W. R., Bartsch Tags: Retina Original articles - Clinical science Source Type: research

Diabetes and diabetic retinopathy in people aged 50 years and older in the Republic of Suriname
Conclusions The prevalence of diabetes and diabetics without regular DR control in people aged ≥50 years in Suriname was higher than expected. The uptake for special services for DR has to be expanded to decrease patient delay and DR-induced blindness. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Minderhoud, J., Pawiroredjo, J. C., Bueno de Mesquita-Voigt, A.-M. T., Themen, H. C., Siban, M. R., Forster-Pawiroredjo, C. M., Limburg, H., van Nispen, R. M., Mans, D. R., Moll, A. C. Tags: Retina, Vision, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Retinal sensitivity in subjects with type 2 diabetes mellitus: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS II, Report No. 4)
Conclusions Reduced RS in those subjects with diabetes but no retinopathy suggests the early neuronal damage in type 2 diabetes mellitus. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Gella, L., Raman, R., Kulothungan, V., Saumya Pal, S., Ganesan, S., Sharma, T. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

A prospective randomised controlled clinical trial comparing a combination of repeated intravitreal Ozurdex and macular laser therapy versus macular laser only in centre-involving diabetic macular oedema (OZLASE study)
Conclusions Visual outcome following combination therapy did not differ from MLT alone in the centre-involving DMO despite a significant decrease in CST likely due to an entry visual acuity-related ceiling effect and cataract development. Trial registration number EudraCT 2011-003339-74 (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Heng, L. Z., Sivaprasad, S., Crosby-Nwaobi, R., Saihan, Z., Karampelas, M., Bunce, C., Peto, T., Hykin, P. G. Tags: Lens and zonules, Retina, Editor's choice, Epidemiology Original articles - Clinical science Source Type: research

Anatomical effects of dexamethasone intravitreal implant in diabetic macular oedema: a pooled analysis of 3-year phase III trials
Conclusions DEX implant 0.7 or 0.35 mg, administered at ≥6-month intervals over 3 years, produced sustained retinal structural improvement in DME. Trial registration number NCT00168337 and NCT00168389. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Danis, R. P., Sadda, S., Li, X.-Y., Cui, H., Hashad, Y., Whitcup, S. M. Tags: Retina, Open access Original articles - Clinical science Source Type: research

Ranibizumab 0.5 mg treat-and-extend regimen for diabetic macular oedema: the RETAIN study
Conclusions T&E is a feasible treatment option for patients with DMO, with a potential to reduce treatment burden. Slightly more injections were required versus PRN, likely due to the specifics of the T&E regimen applied here. Trial registration number NCT01171976. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Prünte, C., Fajnkuchen, F., Mahmood, S., Ricci, F., Hatz, K., Studnicka, J., Bezlyak, V., Parikh, S., Stubbings, W. J., Wenzel, A., Figueira, J., and the RETAIN Study Group Tags: Open access Original articles - Clinical science Source Type: research

Long-term treatment with rituximab in severe juvenile idiopathic arthritis-associated uveitis
Conclusions Rituximab may be a promising effective treatment option for refractory uveitis associated with JIA leading to long-term quiescence of uveitis, particularly for patients who have not previously responded to other biologic therapies. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Miserocchi, E., Modorati, G., Berchicci, L., Pontikaki, I., Meroni, P., Gerloni, V. Tags: Original articles - Clinical science Source Type: research

Visual phenomena perceived during pars plana vitrectomy under peribulbar block and monitored anaesthesia care
Conclusions The reported prevalence of intraoperative visual phenomena is low when elicited at the first postoperative visit. Surgeons can reliably predict patients’ comfort, and most patients react neutrally to visual and hearing phenomena during PPV under MAC with peribulbar block. The combination of medications used may be responsible for the neutral reception of sensory phenomena. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Ramkumar, H. L., Khatibi, A., Freeman, W. R., Barteselli, G., Ezon, I. C., Amini, P., Sharpsten, L., Arcinue, C. A., Nezgoda, J. T., Ferreyra, H. A., Goldbaum, M. H. Tags: Ophthalmologic surgical procedures, Neurology Original articles - Clinical science Source Type: research

Severe adverse events associated with local anaesthesia in cataract surgery: 1 year national survey of practice and complications in the UK
Conclusions There has been a large swing towards ‘non-injection’ LA in recent years. Serious adverse events were reported with all techniques except topical-intracameral and subconjunctival LA, though the incidence appears lower for ‘non-injection’ LA. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Lee, R. M. H., Thompson, J. R., Eke, T. Tags: Cornea, Lens and zonules, Ocular surface Original articles - Clinical science Source Type: research

Ophthalmology trainees self-assessment of cataract surgery
Conclusions Trainees were more proficient at assessing their own competence at the global indices of cataract surgery, rather than task-specific components. Compared with junior trainees, senior trainees performed better surgically and were more proficient at assessing their own competence in cataract surgery. Trial registration number SALH1001. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Casswell, E. J., Salam, T., Sullivan, P. M., Ezra, D. G. Tags: Ophthalmologic surgical procedures, Lens and zonules Original articles - Clinical science Source Type: research

Agreement between novice and experienced trachoma graders improves after a single day of didactic training
Conclusion A single day of training improves agreement between prospective and experienced trachoma graders, and provides the basis for certification of workers who are able to accurately grade trachoma and generate reliable prevalence estimates. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Prasad, B. P., Bhatta, R. C., Chaudhary, J., Sharma, S., Mishra, S., Cuddapah, P. A., Stoller, N. E., Yu, S. N., Rahman, S. A., Deiner, M., Keenan, J. D., Gaynor, B. D. Tags: Conjunctiva, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research