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Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells
Conclusions This study provides evidence of a novel mechanotransduction pathway linking mechanical strain, cation channel function and the induction of LC cell matrix gene transcription. This highlights the potential involvement of calcium influx in the activation of matrix remodelling responses in the optic nerve head and supports the rationale that calcium channel blockers may attenuate disease progression in glaucoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Quill, B., Irnaten, M., Docherty, N. G., McElnea, E. M., Wallace, D. M., Clark, A. F., O'Brien, C. J. Tags: Angle, Intraocular pressure, Editor's choice, Glaucoma Original articles - Laboratory science Source Type: research

Effect of intravitreal ranibizumab injections on aqueous humour concentrations of vascular endothelial growth factor and pigment epithelium-derived factor in patients with myopic choroidal neovascularisation
Conclusions The VEGF and PEDF levels in aqueous humour were significantly lower in the myopic group than in controls. Moreover, IVR resulted in reduced VEGF and increased PEDF levels in patients with mCNV. In mCNV, neovascularisation is associated with inappropriate VEGF and PEDF expression. A balance between VEGF and PEDF is crucial to prevent CNV development. Trial registration number NCT02175940. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Costagliola, C., Semeraro, F., dell'Omo, R., Romano, M. R., Russo, A., Aceto, F., Mastropasqua, R., Porcellini, A. Tags: Choroid, Optic nerve, Optics and refraction Original articles - Laboratory science Source Type: research

Subjective through-focus quality of vision with various versions of modified monovision
Conclusions Binocular performance could be optimised by choosing different multifocal profiles for each eye and by adding a defocus term between eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Vandermeer, G., Rio, D., Gicquel, J.-J., Pisella, P.-J., Legras, R. Tags: Original articles - Clinical science Source Type: research

Prognostic factors for conjunctival melanoma: a study in ethnic Chinese patients
Conclusions Adjuvant therapy and tumour thickness are significantly associated with RFS and T stage is a significant predictor of OS in Chinese patients with conjunctival melanomas. Patients may benefit from adjuvant therapy with HDI. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Sheng, X., Li, S., Chi, Z., Si, L., Cui, C., Mao, L., Lian, B., Tang, B., Wang, X., Yan, X., Kong, Y., Dai, J., Guo, J. Tags: Eye (globe) Original articles - Clinical science Source Type: research

Cost-effectiveness of alternative strategies for interferon-{gamma} release assays and tuberculin skin test in tuberculous uveitis
Conclusions The dual-test strategy (performing TST and IGRA at presentation) was the most cost effective strategy for the diagnosis of tuberculous uveitis in our population. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Ang, M., Nguyen, H. V., Kiew, S. Y., Chen, S., Chee, S.-P., Finkelstein, E. Tags: Epidemiology Original articles - Clinical science Source Type: research

Effectiveness and safety of dexamethasone implants for post-surgical macular oedema including Irvine-Gass syndrome: the EPISODIC study
Conclusions Ozurdex would appear to be an interesting alternative therapy for treating post-surgical macular oedema, including Irvine-Gass syndrome refractory to first-line treatments. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Bellocq, D., Korobelnik, J.-F., Burillon, C., Voirin, N., Dot, C., Souied, E., Conrath, J., Milazzo, S., Massin, P., Baillif, S., Kodjikian, L. Tags: Retina Original articles - Clinical science Source Type: research

Pointwise linear regression analysis of serial Humphrey visual fields and a correlation with electroretinography in birdshot chorioretinopathy
Conclusions This study demonstrates that PLR analysis can identify field loss despite a stable MD and stable and even normal electrophysiology in BCR, thus establishing a role for regular standardised monitoring of visual fields as an adjunct to electrophysiology in order to facilitate more accurate characterisation of retinal dysfunction and hence enabling better-informed treatment decisions and monitoring of treatment efficacy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Arya, B., Westcott, M., Robson, A. G., Holder, G. E., Pavesio, C. Tags: Original articles - Clinical science Source Type: research

Spectral domain optical coherence tomography in patients with sickle cell disease
Conclusions Quantitative and qualitative changes on SD-OCT are present in asymptomatic SCD eyes. Proliferative retinopathy is more prevalent in eyes with discrete areas of macular thinning. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Mathew, R., Bafiq, R., Ramu, J., Pearce, E., Richardson, M., Drasar, E., Thein, S. L., Sivaprasad, S. Tags: Epidemiology Original articles - Clinical science Source Type: research

Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy: possible association with postoperative macular oedema
Conclusions The elevated levels of MCP-1 and IL-6 may indicate prolonged inflammation even after successful vitrectomy, which can cause postoperative DME. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Yoshida, S., Kubo, Y., Kobayashi, Y., Zhou, Y., Nakama, T., Yamaguchi, M., Tachibana, T., Ishikawa, K., Arita, R., Nakao, S., Sassa, Y., Oshima, Y., Kono, T., Ishibashi, T. Tags: Ophthalmologic surgical procedures, Retina Original articles - Clinical science Source Type: research

A randomised, double-masked, controlled study of the efficacy and safety of intravitreal bevacizumab versus ranibizumab in the treatment of macular oedema due to branch retinal vein occlusion: MARVEL Report No. 1
Conclusions This study demonstrated significant gain in visual acuity in eyes with BRVO treated with either bevacizumab or ranibizumab. Pro-re-nata strategy was effective in maintaining the visual gain. Trial registration number http://www.ctri.nic.in/ CTRI/2012/01/003120. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Narayanan, R., Panchal, B., Das, T., Chhablani, J., Jalali, S., Ali, M. H., on behalf of MARVEL study group, on behalf of MARVEL study group, Balakrishnan, Bandi, Bansal, Dave, Kamath, Kumar, Majji, Mathai, Mithal, Kolawale, Partani, Phalak, Rani, Reddy, Tags: Retina Original articles - Clinical science Source Type: research

Neoadjuvant/adjuvant treatment of high-risk retinoblastoma: a report from the German Retinoblastoma Referral Centre
Conclusions This retrospective single-site study reveals a 10% incidence of high-risk features in children with retinoblastoma diagnosed at the German Retinoblastoma Referral Centre. Overall survival rates of 98.3% underline the safety of this adjuvant chemotherapy protocol and its efficiency in preventing metastasis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Kunkele, A., Wilm, J., Holdt, M., Lohmann, D., Bornfeld, N., Eggert, A., Temming, P., Schulte, J. H. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Early diagnosis and successful treatment of paraneoplastic melanocytic proliferation
Conclusions In the past, visual loss due to paraneoplastic melanocytic proliferation was considered progressive and irreversible. We treated two patients successfully with plasmapheresis and demonstrated a relation between CMEP factor in the serum of these patients and proliferation of cultured melanocytes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Jansen, J. C. G., Van Calster, J., Pulido, J. S., Miles, S. L., Vile, R. G., Van Bergen, T., Cassiman, C., Spielberg, L. H., Leys, A. M. Tags: Open access Original articles - Clinical science Source Type: research

Improving survival of retinoblastoma in Uganda
Conclusions The introduction of chemotherapy proved safe and cost-effective in non-specialist hands and was associated with significant improvements in survival and, among bilateral cases, in preserving vision. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Waddell, K. M., Kagame, K., Ndamira, A., Twinamasiko, A., Picton, S. V., Simmons, I. G., Revill, P., Johnston, W. T., Newton, R. Tags: Paediatrics, Public health, Epidemiology Original articles - Clinical science Source Type: research

Intraocular pressure and coronary artery calcification in asymptomatic men and women
Conclusions A higher IOP is significantly associated with the presence of CAC regardless of conventional cardiovascular risk factors. The present study provides more insight into understanding the process of subclinical atherosclerosis in CVD and the relationship with a higher IOP as a common pathophysiology. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Ye, S., Chang, Y., Kim, C.-W., Kwon, M.-J., Choi, Y., Ahn, J., Kim, J. M., Kim, H. S., Shin, H., Ryu, S. Tags: Public health, Angle, Intraocular pressure, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Swept-source optical coherence tomography assessment of iris-trabecular contact after phacoemulsification with or without goniosynechialysis in eyes with primary angle closure glaucoma
Conclusions Eyes that undergo PE+GSL surgery have a greater reduction in circumferential ITC area than eyes that undergo PE alone. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Tun, T. A., Baskaran, M., Perera, S. A., Htoon, H. M., Aung, T., Husain, R. Tags: Ophthalmologic surgical procedures, Angle, Intraocular pressure, Lens and zonules, Glaucoma Original articles - Clinical science Source Type: research

Peripapillary choroidal thickness assessed using automated choroidal segmentation software in an Asian population
Conclusions Using novel automated choroidal segmentation software, we provide reliable objective measurements of PPCT in a population-based setting. Shorter axial length, younger age, lower triglyceride levels and the presence of diabetes are the factors independently associated with thicker PPCT. These factors should be taken into consideration when interpreting Spectralis EDI SD-OCT-based PPCT measurements in clinics. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Gupta, P., Jing, T., Marziliano, P., Baskaran, M., Cheung, G. C. M., Lamoureux, E. L., Cheung, C. Y., Wong, T. Y., Aung, T., Cheng, C.-Y. Tags: Epidemiology Original articles - Clinical science Source Type: research

Outcomes of ab interno trabeculectomy with the trabectome by degree of angle opening
Conclusions SG≤2 is not associated with worse outcomes in AIT or phaco-AIT. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Bussel, I. I., Kaplowitz, K., Schuman, J. S., Loewen, N. A., Trabectome Study Group Tags: Ophthalmologic surgical procedures, Open access Original articles - Clinical science Source Type: research

Sebaceous adenomas of the eyelid and Muir-Torre Syndrome
Conclusions The diagnosis of eyelid SA is rare. The importance of this benign eyelid tumour stems from its association with internal malignancies in MTS. Immunohistochemical staining of mismatch repair proteins MLH1 and MSH2 is a valid and accessible strategy for investigating MTS in patients with SAs. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Jagan, L., Zoroquiain, P., Bravo-Filho, V., Logan, P., Qutub, M., Burnier, M. N. Tags: Original articles - Clinical science Source Type: research

A randomised, parallel-group comparison study of diquafosol ophthalmic solution in patients with dry eye in China and Singapore
Conclusions Diquafosol improved fluorescein staining score in a manner similar to HA, and significantly improved RB score compared with HA. Trial registration number NCT01101984. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Gong, L., Sun, X., Ma, Z., Wang, Q., Xu, X., Chen, X., Shao, Y., Yao, K., Tang, L., Gu, Y., Yuan, H., Chua, W. H., Chuan, J. C. Y., Tong, L. Tags: Original articles - Clinical science Source Type: research

Blepharoptosis surgery in patients with myasthenia gravis
Conclusions Over a third of patients in our series required repeat surgery, which would be expected when the initial aim was to under-correct this group. In contrast to previous commentaries, the amount of eyelid excursion was not the main factor used to guide the surgical approach. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Litwin, A. S., Patel, B., McNab, A. A., McCann, J. D., Leatherbarrow, B., Malhotra, R. Tags: Cornea, Eye Lids, Ocular surface, Neurology Original articles - Clinical science Source Type: research

Measuring rates of structural and functional change in glaucoma
Glaucoma is a progressive optic neuropathy. Hence, most glaucomatous eyes demonstrate signs of deterioration over time despite what may appear to be adequate treatment. The main goal of glaucoma treatment is to slow the rate of disease so that patients can prolong their functional vision. Therefore, it is important for clinicians caring for patients with glaucoma to be able to estimate rates of change with structural and functional outcomes in their patients. Various trend analysis models have been previously used to estimate rates of decay in glaucoma. The authors discuss the relevant issues and the inherent caveats relat...
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Nouri-Mahdavi, K., Caprioli, J. Tags: Angle, Intraocular pressure, Optic nerve, Neurology, Glaucoma Review Source Type: research

Why is the General Ophthalmic Services (GOS) Contract that underpins primary eye care in the UK contrary to the public health interest?
The model for delivery of primary eye care in Europe varies from country to country with differing reliance on ophthalmologists, optometrists and dispensing opticians. Comparative analysis of models has tended to focus on interprofessional working arrangements, training and regulatory issues, rather than on whether a particular model is effective for delivering public health goals for that country. National Health Service (NHS) primary eye care services in the UK are predominantly provided under a General Ophthalmic Services (GOS) Contract between the NHS and practice owners (Contractors). Over two-thirds of sight tests co...
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Shickle, D., Davey, C. J., Slade, S. V. Tags: Public health Review Source Type: research

A brief review of Boston type-1 and osteo-odonto keratoprostheses
Globally there are 4.9 million bilaterally corneal blind and 23 million unilaterally corneal blind. Majority of this blindness exists in the developing countries, where resources for corneal banking and transplant surgery are less than adequate. Survival of corneal grafts gradually declines over the long term. Corneal transplantation has poor prognosis in vascularised corneal beds, ocular surface disease and viral keratitis. Keratoprosthesis (KPro) remains as a final option for end-stage ocular surface disease, multiple corneal transplant failures and high-risk corneal grafts. Boston type-1 KPro and osteo-odonto-keratopros...
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Avadhanam, V. S., Liu, C. S. C. Tags: Ophthalmologic surgical procedures, Cornea, Ocular surface, Vision, Neurology, Epidemiology Review Source Type: research

Novel device for expanding Schlemm's canal: a morphological study: Implantation of the Stegmann Canal Expander following viscodilation of Schlemm's canal resulted in permanent expansion of the canal lumen and distension of the trabecular meshwork without complications
This study was performed to assess any changes in Schlemm's canal (SC) in human autopsy eyes possibly resulting from the injection of a viscoelastic substance and implantation of a new device (the Stegmann Canal Expander, SCE) into SC. After the surgical procedure, eyes were fixed, dissected into quartered segments and examined using light and scanning electron microscopy. Tissue sections displayed a marked dilation of SC and of the collector channels compared with untreated control sections. The SC walls were disrupted in some areas due to viscodilation, but not due to SCE implantation. In all eyes, the entire 9-mm length...
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Grieshaber, M. C., Stegmann, R., Grieshaber, H. R., Meyer, P. Tags: Angle, Intraocular pressure, Glaucoma Innovations Source Type: research

Highlights from this issue
Litwin et al (see page 899) Caution is required when considering functional surgical correction of blepharoptosis for patients with Myasthenia Gravis. There is a high likelihood of need for further surgery because of initial under-correction and despite this, a proportion will develop corneal exposure. Sun et al (see page 903) In dry eye, Diquafosol, compared to sodium hyaluronate, is not inferior in the improvement in corneal fluorescein staining score and superior in terms of rose bengal staining. Jagan et al (see page 909) Sebaceous Adenomas of the eyelid are rare but should be evaluated with immunohistochemical stainin...
Source: British Journal of Ophthalmology - June 22, 2015 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

High-irradiance CXL combined with myopic LASIK: flap and residual stroma biomechanical properties studied ex-vivo
Conclusions LASIK+CXL appears to provide significant increase in underlying corneal stromal rigidity, up to +130%. Additionally, there is significant relevant enzymatic digestion resistance confirmatory to the above. LASIK flaps appear unaffected biomechanically by the LASIK+CXL procedure, suggesting effective CXL just under the flap. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Kanellopoulos, A. J., Asimellis, G., Salvador-Culla, B., Chodosh, J., Ciolino, J. B. Tags: Ophthalmologic surgical procedures Original articles - Laboratory science Source Type: research

Compatibility of recombinant tissue plasminogen activator (rtPA) and aflibercept or ranibizumab coapplied for neovascular age-related macular degeneration with submacular haemorrhage
Conclusions Ranibizumab is not cleaved or functionally compromised by rtPA or plasmin. Aflibercept is cleaved and its VEGF-binding ability is reduced when coapplied with plasmin. In clinical practice, rtPA and ranibizumab can be coapplied as a treatment for neovascular age-related macular degeneration with submacular haemorrhage while the antiangiogenic activity of aflibercept may be compromised when coapplied with rtPA in the presence of plasmin. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Klettner, A., Groteluschen, S., Treumer, F., Roider, J., Hillenkamp, J. Tags: Retina, Editor's choice Original articles - Laboratory science Source Type: research

Outcomes of epiretinal membrane surgery in highly myopic eyes: a case-control study
Conclusions ERM surgery resulted in similar anatomical and functional outcomes in both groups. Longer axial length does not seem to affect visual improvement and the complication rate. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Conart, J.-B., Favel, C., Selton, J., Hubert, I., Cloche, V., Trechot, F., Berrod, J.-P. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Retinal nerve fibre layer thickness measurements after successful retinal detachment repair with silicone oil endotamponade
Conclusions In patients with silicone oil tamponade, peripapillary RNFL was significantly thicker in comparison with fellow unoperated eyes over a 6-month period. Trial registration number NCT 01255306. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Zoric Geber, M., Bencic, G., Vatavuk, Z., Ivekovic, R., Friberg, T. R. Tags: Ophthalmologic surgical procedures, Retina Original articles - Clinical science Source Type: research

A prospective pilot study of intravitreal aflibercept for the treatment of chronic central serous chorioretinopathy: the CONTAIN study
Conclusions Intravitreal aflibercept was well tolerated over a 6-month treatment course for chronic CSCR. No change was observed in visual acuity metrics. Anatomic trends may suggest some morphological activity, but larger controlled trials are needed. Trial registration number NCT01710332 (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Pitcher, J. D., Witkin, A. J., DeCroos, F. C., Ho, A. C. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

MultiColor imaging in the evaluation of geographic atrophy due to age-related macular degeneration
Conclusions We demonstrated that several different imaging modalities currently available in clinical practice are reliable for evaluating GA due to AMD. MultiColor is an excellent tool for the measurement of GA area and width, and for the detection of foveal sparing. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Moussa, N. B., Georges, A., Capuano, V., Merle, B., Souied, E. H., Querques, G. Tags: Retina Original articles - Clinical science Source Type: research

Relationship of systemic endothelial function and peripheral arterial stiffness with diabetic retinopathy
Conclusions Subjects with more severe DR have larger peripheral reactive hyperaemic responses and greater peripheral vascular stiffness. These findings support the link between the microvascular changes of diabetes and macrovascular disease. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Lim, L. S., Ling, L. H., Cheung, C. M. G., Ong, P. G., Gong, L., Tai, E. S., Mathur, R., Wong, D., Foulds, W., Wong, T. Y. Tags: Public health, Retina Original articles - Clinical science Source Type: research

Rapid assessment of avoidable blindness and diabetic retinopathy in Republic of Moldova
Conclusions The RAAB+DR survey in the Republic of Moldova established that untreated cataract is the major cause of avoidable blindness in rural areas. This needs to be tackled by expanding the geographical coverage of cataract surgical services. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Zatic, T., Bendelic, E., Paduca, A., Rabiu, M., Corduneanu, A., Garaba, A., Novac, V., Curca, C., Sorbala, I., Chiaburu, A., Verega, F., Andronic, V., Guzun, I., Capatina, O., Zama-Mardari, I. Tags: Angle, Intraocular pressure, Lens and zonules, Retina, Vision, Neurology, Glaucoma Original articles - Clinical science Source Type: research

Telemedicine for detecting diabetic retinopathy: a systematic review and meta-analysis
Conclusions The diagnostic accuracy of telemedicine using digital imaging in DR is overall high. It can be used widely for DR screening. Telemedicine based on the digital imaging technique that combines mydriasis with a wide angle field (100–200°) is the best choice in detecting the absence of DR and the presence of mild NPDR. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Shi, L., Wu, H., Dong, J., Jiang, K., Lu, X., Shi, J. Tags: Public health, Retina, Pupil, Open access, Epidemiology Original articles - Clinical science Source Type: research

Prognostic factors of 2-year outcomes of ranibizumab therapy for polypoidal choroidal vasculopathy
Conclusions Patient age, baseline VA and clusters of grape-like polypoidal lesions predicted VA outcomes 2 years after treatment with IVR for PCV. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Hikichi, T., Kitamei, H., Shioya, S. Tags: Choroid Original articles - Clinical science Source Type: research

Proton beam radiotherapy of diffuse iris melanoma in 54 patients
Conclusions As an alternative to enucleation, whole anterior segment fractionated proton beam radiotherapy offered excellent local tumour control in diffuse iris melanoma. Given the limited alternatives, the rate of complications appears acceptable and visual function could be preserved in the majority of the patients during follow-up. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Willerding, G. D., Cordini, D., Hackl, C., Karle, B., Lakotka, N., Foerster, M. H., Bechrakis, N. N., Heufelder, J., Moser, L., Joussen, A. M. Tags: Angle, Intraocular pressure, Lens and zonules, Glaucoma Original articles - Clinical science Source Type: research

Incidence and treatment of retinopathy of prematurity in England between 1990 and 2011: database study
Conclusions Increased neonatal survival, improved awareness of ROP and dissemination of guidance on screening and treatment of ROP will all have contributed to the substantial rise in recorded incidence of ROP between 1990 and 2011. Retinal ablation is now almost always performed using laser treatment rather than cryotherapy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Painter, S. L., Wilkinson, A. R., Desai, P., Goldacre, M. J., Patel, C. K. Tags: Paediatrics, Public health, Retina, Epidemiology Original articles - Clinical science Source Type: research

Visual impairment due to retinopathy of prematurity (ROP) in New Zealand: a 22-year review
Conclusions There has been a reduction in the incidence of infants with significant visual impairment from ROP over time in New Zealand, likely due to progress in clinical management of ROP. Our study suggests the current ROP screening criteria of <31 weeks' gestation or <1250 g are of sufficient breadth. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Tan, Z., Chong, C., Darlow, B., Dai, S. Tags: Retina, Vision, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Quantitative comparison of macular segmentation performance using identical retinal regions across multiple spectral-domain optical coherence tomography instruments
Conclusions By comparison of identical regions, substantial differences were detected between the tested OCT devices regarding technical accuracy and clinical impact. Spectralis showed lowest error incidence but highest error impact. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Waldstein, S. M., Gerendas, B. S., Montuoro, A., Simader, C., Schmidt-Erfurth, U. Tags: Original articles - Clinical science Source Type: research

Morphologic and vasculature features of the choroid and associated choroid-retinal thickness alterations in neurofibromatosis type 1
Conclusions In NF1, there are dome-shaped and placcoid choroidal nodules which alter choroidal morphology and thickness. There is reduction in mean choroid thickness with generalised thinning of the neuroepithelium, photoreceptors together with RPE and ONL in NF1 patients. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Abdolrahimzadeh, S., Felli, L., Plateroti, R., Plateroti, A. M., Giustini, S., Calvieri, S., Recupero, S. M. Tags: Neurology Original articles - Clinical science Source Type: research

Influence of graft size on graft survival following Descemet stripping automated endothelial keratoplasty
Conclusions Larger grafts occupy a smaller chord length in the eye than the trephine size and are expected to provide 10%–20% more endothelial cells. Increased graft size and donor ECD is significantly associated with a reduced graft failure rate. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Romano, V., Tey, A., Hill, N. M. E., Ahmad, S., Britten, C., Batterbury, M., Willoughby, C., Kaye, S. B. Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Modified lamellar keratoplasty and immunosuppressive therapy guided by in vivo confocal microscopy for perforated Mooren's ulcer
Conclusions Modified LK, combined with immunosuppressive therapy, can effectively treat perforated Mooren's ulcer, with few complications. The use of corticosteroids and immunosuppressants guided by IVCM may reduce the disease recurrence. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Liu, J., Shi, W., Li, S., Gao, H., Wang, T. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Efficacy and safety of pre-Descemet's membrane sutures for the management of acute corneal hydrops in keratoconus
Conclusions Our results suggest that intrastromal pre-DM sutures and intracameral air injection could promptly restore imperviousness of posterior stroma. This technique seems to be a safe and useful procedure to shorten acute corneal hydrops. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Yahia Cherif, H., Gueudry, J., Afriat, M., Delcampe, A., Attal, P., Gross, H., Muraine, M. Tags: Cornea, Ocular surface Original articles - Clinical science Source Type: research

Spontaneous long-term course of persistent peripheral graft detachments after Descemet's membrane endothelial keratoplasty
Conclusions Persistent peripheral graft detachments after DMEK occurred in 10% of patients and had two distinct OCT-phenotypes. Peripheral rolls did not change during the first 12 months, postoperatively. By contrast, peripheral laminar detachments attached spontaneously even months after surgery. Corneal thickness reduction was only observed above peripheral laminar detachment, but not above peripheral rolls. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Bucher, F., Hos, D., Muller-Schwefe, S., Steven, P., Cursiefen, C., Heindl, L. M. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Migration study of lens opacities in Bangladeshi adults in London and Bangladesh: a pilot study
Discussion The study highlights the challenges of migration studies, and of studies involving ethnic minorities. Preliminary findings suggest that migration to the UK is protective for LO despite a significantly higher rate of diabetes in the UK. A larger study is warranted based on these preliminary findings. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Finger, R. P., Sivasubramaniam, S., Morjaria, P., Bansal, A., Muhit, M., Kinra, S., Gilbert, C. E. Tags: Lens and zonules Original articles - Clinical science Source Type: research

Ocular alignment after bilateral lateral rectus recession in exotropic children with cerebral palsy
Conclusions CP patients with exotropia showed successful ocular alignment comparable to that of controls after BLR recession of at least 2 years. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Han, S. Y., Han, J., Han, S.-H., Lee, J. B., Rhiu, S. Tags: Paediatrics, Muscles, Neurology Original articles - Clinical science Source Type: research

Normative data for three tests of visuocognitive function in primary school children: cross-sectional study
Conclusions These different aspects of children’s visuocognitive performance were testable in a field setting. The data provide a benchmark by which to judge performance of children with neurodevelopmental problems and may be useful in assessment with a view to providing effective supportive strategies for children whose visuocognitive skills are lower than the expectation for their age. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Williams, C., Gilchrist, I. D., Fraser, S., McCarthy, H., Parker, J., Warnes, P., Young, J., Hyvarinen, L. Tags: Open access, Epidemiology Original articles - Clinical science Source Type: research

Significance of corneal biomechanical properties in patients with progressive normal-tension glaucoma
Conclusions Corneal biomechanical properties are correlated and associated with the progression of visual field damage in NTG patients. These findings suggest that CH can be used as one of the prognostic factors for progression, independent of corneal thickness or intraocular pressure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Park, J. H., Jun, R. M., Choi, K.-R. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

A randomised, controlled comparison of latanoprostene bunod and latanoprost 0.005% in the treatment of ocular hypertension and open angle glaucoma: the VOYAGER study
Conclusions LBN 0.024% dosed once daily was the lower of the two most effective concentrations evaluated, with significantly greater IOP lowering and comparable side effects relative to latanoprost 0.005%. LBN dosed once daily for 28 days was well tolerated. Clinical trial number NCT01223378. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Weinreb, R. N., Ong, T., Scassellati Sforzolini, B., Vittitow, J. L., Singh, K., Kaufman, P. L., Ackerman, Branch, Cottingham, Day, Depenbusch, El-Hazari, Firozvi, Jorizzo, Ou, Peace, Rotberg, Schenker, Smith, Tyson, Zaman, Madzharova, Toshev, Vassilveva, Tags: Angle, Intraocular pressure, Open access, Glaucoma Original articles - Clinical science Source Type: research

Retinal nerve fibre layer thickness floor and corresponding functional loss in glaucoma
Conclusions Global RNFL thinning reaches the floor at a smaller VF loss level with Spectralis than with RTVue. The nasal and temporal quadrants retain thinner residual layers than superior and inferior quadrant RNFL. Measuring RNFL below their minimums will not yield useful clinical information. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2015 Category: Opthalmology Authors: Mwanza, J.-C., Budenz, D. L., Warren, J. L., Webel, A. D., Reynolds, C. E., Barbosa, D. T., Lin, S. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research