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Delivery of macromolecules into the endothelium of whole ex vivo human cornea by femtosecond laser-activated carbon nanoparticles
Conclusions This study shows that a macromolecule can be delivered specifically into ECs of a whole organ-cultured human cornea, using fsL-activated CNPs. The delivery rate was relatively high for a non-viral method. Further optimisation is required to understand and reduce variability in cell mortality. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Jumelle, C., Mauclair, C., Houzet, J., Bernard, A., He, Z., Forest, F., Perrache, C., Gain, P., Thuret, G. Tags: Epidemiology Original articles - Laboratory science Source Type: research

Surgical management of temple-related problems following lateral wall rim-sparing orbital decompression for thyroid-related orbitopathy
Conclusions This is the first paper to show that persistent, troublesome temple-related problems following LWRS orbital decompression can be surgically corrected. Patients should be counselled about the potential risk of these complications when considering LWRS orbital decompression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Siah, W. F., Patel, B. C., Malhotra, R. Tags: Cornea, Muscles, Ocular surface, Orbit, Vision, Neurology Original articles - Clinical science Source Type: research

Evaluation of a new rebound tonometer for self-measurement of intraocular pressure
Conclusions Icare Home tonometry can be used for self-measurement by a majority of trained subjects. IOP measurements obtained using Icare Home tonometry by self-assessment and third party-assessment showed slight underestimation compared with GAT. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Dabasia, P. L., Lawrenson, J. G., Murdoch, I. E. Tags: Original articles - Clinical science Source Type: research

Neuroretinal rim area and ocular haemodynamic parameters in patients with normal-tension glaucoma with differing intracranial pressures
Conclusions Patients with NTG having lower ICP have decreased neuroretinal rim area and OA blood flow parameters compared with patients having higher ICP. Further longitudinal studies are needed to analyse the involvement of ICP in NTG management. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Siaudvytyte, L., Januleviciene, I., Daveckaite, A., Ragauskas, A., Siesky, B., Harris, A. Tags: Angle, Intraocular pressure, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Anxiety in visual field testing
Conclusions HVF testing induces more anxiety than HRT. Increased pretest anxiety may reduce HVF test reliability. Increased test experience or interventions aimed at reducing pretest anxiety may result in improved test reliability and accuracy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Chew, S. S. L., Kerr, N. M., Wong, A. B. C., Craig, J. P., Chou, C.-Y., Danesh-Meyer, H. V. Tags: Angle, Intraocular pressure, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Cycloplegic autorefraction versus subjective refraction: the Tehran Eye Study
Conclusions The cycloplegic refraction is more sensitive than the subjective one to measure refractive error at all age groups especially in children and young adults. The cyclorefraction technique is highly recommended to exactly measure the refractive error in momentous conditions such as refractive surgery, epidemiological researches and amblyopia therapy, especially in hypermetropic eyes and paediatric cases. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Hashemi, H., Khabazkhoob, M., Asharlous, A., Soroush, S., Yekta, A., Dadbin, N., Fotouhi, A. Tags: Paediatrics, Optic nerve, Vision, Neurology, Optics and refraction, Epidemiology Original articles - Clinical science Source Type: research

Assessing visual function in children with complex disabilities: the Bradford visual function box
Conclusions The results of this clinical study show that the BVFB is a reliable tool for assessing the visual function in children with severe learning disability in whom other tests fail to elicit a response. The need for a tool which is quick to administer and portable has previously been highlighted. The BVFB offers an option for children for whom other formal tests are unsuccessful in eliciting a response. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Pilling, R. F., Outhwaite, L., Bruce, A. Tags: Paediatrics, Neurology Original articles - Clinical science Source Type: research

Influence of progressive addition lenses on reading posture in myopic children
Conclusions The lens type and the near phoria state affected near vision posture. During reading, myopic esophoric children used a lower portion of their PALs compared with exophoric children, resulting in greater addition power. These results may partially explain why myopic children with near esophoria exhibited superior treatment effects in myopia control trials using PALs. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Bao, J., Wang, Y., Zhuo, Z., Yang, X., Tan, R., Drobe, B., Chen, H. Tags: Muscles, Optic nerve, Open access, Neurology, Optics and refraction Original articles - Clinical science Source Type: research

Vision screening in children: a retrospective study of social and demographic factors with regards to visual outcomes
Conclusions We found that children from the most deprived backgrounds and those from unstable homes were more likely to fail preschool vision screening. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: O'Colmain, U., Low, L., Gilmour, C., MacEwen, C. J. Tags: Public health, Vision, Open access, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Successful management of severe unilateral chemical burns in children using simple limbal epithelial transplantation (SLET)
Conclusions SLET appears to be a promising technique for treatment of LSCD secondary to ocular surface burns in children. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Mittal, V., Jain, R., Mittal, R., Vashist, U., Narang, P. Tags: Paediatrics Original articles - Clinical science Source Type: research

Iritis, glaucoma and corneal decompensation associated with BrightOcular cosmetic iris implant
Conclusions Cosmetic iris implants carry the risk of ocular damage when implanted in the anterior chamber of normal phakic eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Mansour, A. M., Ahmed, I. I. K., Eadie, B., Chelala, E., Saade, J. S., Slade, S. G., Mearza, A. A., Parmar, D., Ghabra, M., Luk, S., Kelly, A., Kaufman, S. C. Tags: Angle, Choroid, Eye (globe), Intraocular pressure, Iris, Editor's choice, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Long-term visual acuity, retention and complications observed with the type-I and type-II Boston keratoprostheses in an Irish population
Conclusions These data demonstrate excellent visual acuity and retention outcomes in a cohort with a long follow-up period in a single centre. Complications remain a considerable source of morbidity. These outcomes provide further evidence for the long-term stability of type-I and type-II Boston keratoprostheses in the management of patients in whom a traditional graft is likely to fail. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Duignan, E. S., Ni Dhubhghaill, S., Malone, C., Power, W. Tags: Angle, Choroid, Eye (globe), Intraocular pressure, Retina, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

The efficacy of lens removal plus IOL implantation for the treatment of spherophakia with secondary glaucoma
Conclusions Both phacoemulsification+CTR+IOL and lensectomy with scleral-fixated PC IOL implantation are effective in lowering the IOP and enhancing the visual acuity in patients with spherophakia and secondary glaucoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Yang, J., Fan, Q., Chen, J., Wang, A., Cai, L., Sheng, H., Lu, W., Jiang, Y., Lu, Y. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Spontaneous rupture of the lens capsule in hypermature cataract: presentations and outcomes
Conclusion Spontaneous lens capsule rupture can occur in hypermature senile cataract (HMSC) and result in anterior or posterior dislocation of the nucleus or spontaneous resorption with or without an accompanying inflammatory reaction of varying severity. An acceptable visual outcome can be obtained, except in the presence of associated glaucoma or corneal decompensation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Goel, N., Nagar, M. Tags: Angle, Cornea, Intraocular pressure, Lens and zonules, Ocular surface, Glaucoma Original articles - Clinical science Source Type: research

Early versus delayed intravitreal betamethasone as an adjuvant in the treatment of presumed postoperative endophthalmitis: a randomised trial
Conclusions Early intravitreal betamethasone had no clear advantage versus delayed injection in the management of presumed postoperative endophthalmitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Koehrer, P., Bron, A. M., Chiquet, C., Thuret, G., Delbosc, B., Berrod, J.-P., Bourcier, T., Sauer, A., Jonval, L., D'Athis, P., Creuzot-Garcher, C. Tags: Ophthalmologic surgical procedures, Choroid, Eye (globe), Retina Original articles - Clinical science Source Type: research

Mycophenolate sodium for the treatment of chronic non-infectious uveitis of childhood
Conclusion Our data suggest that MPS is useful and well tolerated in children with chronic uveitis. MPS seems to be an effective drug for the treatment of chronic non-infectious uveitis of childhood and may be preferred as a first-line steroid-sparing agent in this form of uveitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Doycheva, D., Zierhut, M., Blumenstock, G., Sobolewska, B., Voykov, B., Hohmann, J., Spitzer, M. S., Deuter, C. Tags: Choroid, Ciliary body Original articles - Clinical science Source Type: research

Efficacy and safety of immunosuppressive agents in the treatment of necrotising scleritis: a retrospective, multicentre study in Korea
Conclusion The efficacy of cyclophosphamide in the treatment of necrotising scleritis was comparable with that of other ISAs. However, the rate of discontinuation due to side effects was much higher in the CYC group. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Jeon, H. S., Hyon, J. Y., Kim, M. K., Chung, T.-Y., Yoon, K. C., Kim, J. Y., Na, K.-S., Kim, H. J., Kim, T.-I., Lee, J. S., Lee, H. K., Song, J. S. Tags: Sclera and apisclera Original articles - Clinical science Source Type: research

Scleritis in patients with granulomatosis with polyangiitis (Wegener)
Conclusions The presence of necrotising changes or corneal involvement in the setting of scleral inflammation is highly suggestive of an underlying systemic vasculitis, of which GPA is the most common. These features should alert the doctor/optometrist and prompt a thorough diagnostic approach and an aggressive treatment given that it could reveal a life-threatening disease. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Cocho, L., Gonzalez-Gonzalez, L. A., Molina-Prat, N., Doctor, P., Sainz-de-la-Maza, M., Foster, C. S. Tags: Angle, Choroid, Intraocular pressure, Sclera and apisclera, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Incidence and clinical features of post-injection endophthalmitis according to diagnosis
Conclusions Endophthalmitis rates appear to be lower in eyes with RVO compared with diabetic eye disease and neovascular AMD, possibly due to impaired immunity in diabetics and waning immunity in the generally older AMD population. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Rayess, N., Rahimy, E., Shah, C. P., Wolfe, J. D., Chen, E., DeCroos, F. C., Storey, P., Garg, S. J., Hsu, J. Tags: Choroid, Eye (globe), Retina, Epidemiology Original articles - Clinical science Source Type: research

Predicting vision gains with anti-VEGF therapy in neovascular age-related macular degeneration patients by using low-luminance vision
Conclusions The baseline BCVA–LLVA gap is a significant predictor of visual acuity response to anti-VEGF treatment in patients with wAMD. Trial registration number NCT00891735; Post-results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Frenkel, R. E. P., Shapiro, H., Stoilov, I. Tags: Retina, Open access Original articles - Clinical science Source Type: research

Extramacular drusen are highly associated with age-related macular degeneration, but not with CFH and ARMS2 genotypes
Conclusions The strong association between drusen within and outside of the macula suggests a common pathogenesis. However, EMD were not AMD-independently associated with CFH or ARMS2 genotypes. Our results indicate that patients without AMD but with EMD can serve as controls in studies evaluating AMD risk factors. Further studies are required to elucidate the aetiology and clinical relevance of EMD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Ersoy, L., Schick, T., de Graft, D., Felsch, M., Hoyng, C., den Hollander, A., Kirchhof, B., Fauser, S., Liakopoulos, S. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Metabolic syndrome and retinal microvascular calibre in a high cardiovascular disease risk cohort
Conclusions Metabolic syndrome is independently associated with narrower retinal arterioles but not wider retinal venules among those at high risk of CAD. The association between metabolic syndrome and narrower retinal arterioles is likely due to the presence of CAD or hypertension in individuals with this syndrome, as the association is not significant in individuals without hypertension or without CAD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Wang, S. B., Mitchell, P., Plant, A. J. H., Phan, K., Liew, G., Thiagalingam, A., Burlutsky, G., Gopinath, B. Tags: Public health Original articles - Clinical science Source Type: research

Influence of epiretinal membrane on the measurement of peripapillary retinal nerve fibre layer thickness using spectral-domain coherence tomography
Conclusions Temporal and global peripapillary RNFL thickness is significantly higher in eyes with ERM, especially when the ERM extends into the peripapillary area. However, some eyes with an ERM that does not involve the peripapillary scan area still show peripapillary RNFL thickening. Measured peripapillary RNFL thickness was significantly and positively correlated with ERM severity. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Lee, Y. H., Bae, H. W., Seo, S. J., Lee, S. Y., Beon, S. H., Kang, S., Kim, C. Y. Tags: Retina Original articles - Clinical science Source Type: research

En face enhanced depth imaging optical coherence tomography of polypoidal choroidal vasculopathy
Conclusions En face OCT imaging using SD-OCT is an easy, reproducible, non-invasive and effective tool to visualise and to understand retinal and choroidal changes PCV. It provides complementary morphological information, describes new semiological entities and might substitute other exams in the future, without dye injection. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Semoun, O., Coscas, F., Coscas, G., Lalloum, F., Srour, M., Souied, E. H. Tags: Choroid Original articles - Clinical science Source Type: research

RPGR-associated retinopathy: clinical features, molecular genetics, animal models and therapeutic options
Retinitis pigmentosa GTPase regulator (RPGR) gene sequence variants account for the vast majority of X linked retinitis pigmentosa (RP), which is one of the most severe forms of RP. Symptoms of nyctalopia typically begin in childhood, with increasing loss of peripheral visual field during teenage years, and progressive central visual loss during the second to fourth decade of life. There is however marked intrafamilial and interfamilial phenotypic heterogeneity in affected males and carrier females. There is now a far greater understanding of the range of phenotypes associated with variants in this gene; including rod-cone...
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Tee, J. J. L., Smith, A. J., Hardcastle, A. J., Michaelides, M. Tags: Eye (globe), Retina, Vision Review Source Type: research

Risk factors for CMV retinitis among individuals with HIV and low CD4 count in northern Thailand: importance of access to healthcare
Conclusions CD4 count, low income and longer travel time to clinic were significant risk factors for CMV retinitis among patients with HIV in a resource-limited setting. These results suggest that reducing blindness from CMV retinitis should focus on increasing accessibility of screening examinations to poor and hard-to-reach patients. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Leenasirimakul, P., Liu, Y., Jirawison, C., Khienprasit, N., Kamphaengkham, S., Ausayakhun, S., Chen, J., Yen, M., Heiden, D., Holland, G. N., Margolis, T. P., Keenan, J. D. Tags: Eye (globe), Retina, Vision, Neurology, Epidemiology Global issues Source Type: research

Highlights from this issue
Semoun et al (see page 1028) In a retrospective descriptive study of 30 patients, en face OCT imaging using SD-OCT was observed to be an easy, reproducible and non-invasive tool to visualise and to understand retinal and choroidal changes in PCV. Kim et al (see page 1035) In an observational, comparative study of 134 patients with idiopathic ERM and 63 healthy controls, temporal peripapillary retinal nerve fiber layer thickness was significantly greater, especially when the ERM extended into the peripapillary area. Gopinath et al (see page 1041) Metabolic syndrome is independently associated with narrower retinal arteriole...
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

Correction: Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension
Lewis RA, Levy B, Ramirez N, et al. Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension. Br J Ophthalmol 2016;100:339–44. The trial registration number is listed as NCT02207491. That is the number for a different study of AR-13324. The correct number is NCT02057575. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Tags: Corrections Source Type: research

Correction: Effect of the pigment-free optical zone diameter of decorative tinted soft contact lenses on visual function
Jung JW, Kim SM, Han SH, et al. Effect of the pigment-free optical zone diameter of decorative tinted soft contact lenses on visual function. Br J Ophthalmol 2016;100:633–37. In the Funding statement, the grant number is incorrect. "Yonsei University College of Medicine for 2014 (6-2014-0036)." should read "Yonsei University College of Medicine for 2014 (6-2014-0159)." (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Tags: Corrections Source Type: research

Correction: Choroidal thickness in children with hyperopic anisometropic amblyopia
Nishi T, Ueda T, Hasegawa T, et al. Choroidal thickness in children with hyperopic anisometropic amblyopia. Br J Ophthalmol 2014;98:228–32. Figure 2A and 2B have been labelled the wrong way round in the Figure 2 caption. Figure 2A is the amblyopic eye and 2B is fellow eye. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Tags: Corrections Source Type: research

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas
Conclusions Chromosomal aberrations seen in posterior UM can also be demonstrated using MLPA or MSA in both treatment naïve and PBR-treated IM. Most IM display a low-metastatic risk chromosomal profile. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Krishna, Y., Kalirai, H., Thornton, S., Damato, B. E., Heimann, H., Coupland, S. E. Tags: Eye (globe), Epidemiology Original articles - Laboratory science Source Type: research

Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation
Conclusions Balancing proper healing and good vision is crucial in the cornea, constantly exposed to potential injuries. In this paper, we suggest the existence of a mechanism regulating the onset of inflammation (and associated CNV) depending on injury severity. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Ferrari, G., Giacomini, C., Bignami, F., Moi, D., Ranghetti, A., Doglioni, C., Naldini, L., Rama, P., Mazzieri, R. Tags: Cornea, Ocular surface Original articles - Laboratory science Source Type: research

Efficacy of dexamethasone versus bevacizumab on regression of hard exudates in diabetic maculopathy: data from the BEVORDEX randomised clinical trial
Conclusions Bevacizumab and DEX were effective in reducing area of HEX in eyes with DME. DEX provided more rapid regression of HEX from the foveal centre although bevacizumab-treated eyes started to catch up by 24 months. Distance from the foveal centre as well as total area of macular HEX should be assessed when evaluating treatments for foveal-threatening HEX. Trial registration number NCT01298076; Post-results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Mehta, H., Fraser-Bell, S., Yeung, A., Campain, A., Lim, L. L., Quin, G. J., McAllister, I. L., Keane, P. A., Gillies, M. C. Tags: Original articles - Clinical science Source Type: research

Comparison of macular choroidal thicknesses from swept source and spectral domain optical coherence tomography
Conclusions CT measurements between automated segmentations from the DRI OCT-1 and manual segmentations on the Spectralis OCT may differ by more than 50 µm. This difference can be reduced, but not eliminated, by manual adjustment of segmentation boundaries by trained graders, and should be accounted for when comparing results between the two devices. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Tan, C. S., Cheong, K. X., Lim, L. W., Sadda, S. R. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Behcet's disease ocular attack score 24 and visual outcome in patients with Behcet's disease
Conclusions BOS24-5Y was found to be a significant positive prognostic index for VA deterioration in patients with ocular Behcet's disease. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Tanaka, R., Murata, H., Takamoto, M., Ohtomo, K., Okinaga, K., Yoshida, A., Kawashima, H., Nakahara, H., Fujino, Y., Kaburaki, T. Tags: Choroid Original articles - Clinical science Source Type: research

The impact of donor age and endothelial cell density on graft survival following penetrating keratoplasty
Conclusions We were unable to detect a significant effect of donor age, up to 90 years, and preoperative donor ECD, above the lower limit of 2200 cells/mm2, on endothelial failure at 5 years following PK. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Wakefield, M. J., Armitage, W. J., Jones, M. N. A., Kaye, S. B., Larkin, D. F. P., Tole, D., Prydal, J., on behalf of the National Health Service Blood and Transplant Ocular Tissue Advisory Group (OTAG Audit Study 19) Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Evaluation of the efficacy and safety of a standardised intracameral combination of mydriatics and anaesthetics for cataract surgery
Conclusions Mydrane is an effective and safe alternative to standard eye drops for initiating and maintaining intraoperative mydriasis and analgesia. Patients who received IC Mydrane were significantly more comfortable before IOL insertion than the reference group. Surgeons found IOL insertion less technically challenging with IC Mydrane. Trial registration number NCT02101359; Results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Labetoulle, M., Findl, O., Malecaze, F., Alio, J., Cochener, B., Lobo, C., Lazreg, S., Hartani, D., Colin, J., Tassignon, M.-J., Behndig, A., on behalf of the Intracameral Mydrane Study 2 Group, on behalf of the Intracameral Mydrane Study 2 Group, Bonicel Tags: Ophthalmologic surgical procedures, Lens and zonules, Pupil, Open access Original articles - Clinical science Source Type: research

Efficacy of conjunctival resection with cyanoacrylate glue application in preventing recurrences of Mooren's ulcer
Conclusions Conjunctival resection and cyanoacrylate glue application are not effective in avoiding recurrences and halting the disease progression in cases of Mooren's ulcer. Systemic immunosuppression remains the mainstay of therapy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Lal, I., Shivanagari, S. B., Ali, M. H., Vazirani, J. Tags: Original articles - Clinical science Source Type: research

Influence of involuntary eyelid spasms on corneal topographic and eyelid morphometric changes in patients with hemifacial spasm
Conclusions The results suggest that treatment with BTX-A in patients with HFS leads to eyelid and corneal changes on the affected eye that are significant during the known period of action of the toxin. Thus, caution should be taken when performing ophthalmological examination in patients with HFS, since it may vary according to BTX-A period of action. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Osaki, T., Osaki, M. H., Osaki, T. H., Hirai, F. E., Nallasamy, N., Campos, M. Tags: Optic nerve, Neurology, Optics and refraction Original articles - Clinical science Source Type: research

Assessment of estimated retinal atrophy progression in Stargardt macular dystrophy using spectral-domain optical coherence tomography
Conclusions SD-OCT measurements allow monitoring the decline in retinal volume in STGD1; however, they require significant manual correction of software errors. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Strauss, R. W., Munoz, B., Wolfson, Y., Sophie, R., Fletcher, E., Bittencourt, M. G., Scholl, H. P. N. Tags: Retina, Open access Original articles - Clinical science Source Type: research

Triamcinolone during pars plana vitrectomy for open globe trauma: a pilot randomised controlled clinical trial
Conclusions An RCT in this population is deliverable and estimated recruitment rates are realistic. Results and patient discussions determined that the definitive study should have vision as a primary outcome. This pilot study is supportive of there being a positive treatment effect of intensive anti-inflammatory agents in OGT. Trial registration number European Clinical Trials Database 2007-005138-35; Results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Banerjee, P. J., Xing, W., Bunce, C., Woodcock, M., Chandra, A., Scott, R. A. H., Charteris, D. G. Tags: Ophthalmologic surgical procedures, Retina, Vitreous, Epidemiology Original articles - Clinical science Source Type: research

Treatment of partial limbal stem cell deficiency with topical interferon {alpha}-2b and retinoic acid
Conclusions Combination treatment of topical IFN α-2b and ATRA 0.01% can be considered in partial LSCD, where adjacent parts of the limbus remain intact. This treatment is associated with minimal side effects and no recurrence of signs of LSCD at least 18 months after clinical resolution. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Tan, J. C., Tat, L. T., Coroneo, M. T. Tags: Original articles - Clinical science Source Type: research

Corynebacterium spp as causative agents of microbial keratitis
Conclusions Corynebacteria can cause severe corneal infection requiring surgical intervention. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Das, S., Rao, A. S., Sahu, S. K., Sharma, S. Tags: Cornea, Eye (globe), Ocular surface, Editor's choice Original articles - Clinical science Source Type: research

Changes in corneal endothelial cell density and the cumulative risk of corneal decompensation after Ahmed glaucoma valve implantation
Conclusions In case of uncomplicated AGV implantation, the cumulative risk of corneal decompensation was 3.3%, 5 years after the operation. The ECD loss was statistically greater in eyes with AGV than in control eyes without AGV, but the difference was significant only up to 2 years post surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Kim, K. N., Lee, S. B., Lee, Y. H., Lee, J. J., Lim, H. B., Kim, C.-s. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Risk factors for low vision related functioning in the Mycotic Ulcer Treatment Trial: a randomised trial comparing natamycin with voriconazole
Conclusions Monocular vision loss from corneal opacity due to fungal keratitis reduced vision-related quality of life. Given the relatively high worldwide burden of corneal opacity, improving treatment outcomes of corneal infections should be a public health priority. Trial registration number Clinicaltrials.gov Identifier: NCT00996736. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Rose-Nussbaumer, J., Prajna, N. V., Krishnan, T., Mascarenhas, J., Rajaraman, R., Srinivasan, M., Raghavan, A., Oldenburg, C. E., O'Brien, K. S., Ray, K. J., Porco, T. C., McLeod, S. D., Acharya, N. R., Keenan, J. D., Lietman, T. M., for the Mycotic Ulcer Tags: Public health, Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface, Vision, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Ocular surface disease in patients with diabetic peripheral neuropathy
Conclusion This study demonstrates some increased clinical signs of ocular surface disease but not an increase in subjective symptoms of dry eyes, with increasing severity of DPN. Furthermore, no significant correlation was found between OSDI scores and clinical signs of dry eye. A periodic evaluation of the ocular surface is important for patients with DM, in addition to retinopathy screening, as they may be asymptomatic but have severe dry eye disease, which can lead to further ocular surface complications such as corneal ulceration. Trial registration number NCT01695629. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: DeMill, D. L., Hussain, M., Pop-Busui, R., Shtein, R. M. Tags: Cornea, Eye (globe), Ocular surface, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Prevalence and clinical correlates of focal choroidal excavation in eyes with age-related macular degeneration, polypoidal choroidal vasculopathy and central serous chorioretinopathy
Conclusions FCE is more common in PCV than AMD-CNV and CSC. Disturbance in the choroid/retinal pigment epithelium/Bruch membrane interface affected by FCE may be linked to the pathogenesis of PCV and AMD-CNV. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Lim, F. P. M., Wong, C. W., Loh, B. K., Chan, C. M., Yeo, I., Lee, S. Y., Mathur, R., Wong, D., Wong, T. Y., Cheung, C. M. G. Tags: Choroid, Retina Original articles - Clinical science Source Type: research

A systematic review of as needed versus treat and extend ranibizumab or bevacizumab treatment regimens for neovascular age-related macular degeneration
Conclusions Though our study suggests superiority of the treat and extend regimen to PRN treatment in a 12-month period, this review demonstrates the need for randomised clinical trials to confirm our findings and to evaluate long-term efficacy outcomes with these regimens compared with monthly therapy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Chin-Yee, D., Eck, T., Fowler, S., Hardi, A., Apte, R. S. Tags: Retina Original articles - Clinical science Source Type: research

Vascular risk factors and rhegmatogenous retinal detachment: a follow-up of a national cohort of Swedish men
Conclusions Vascular risk factors may be important determinants of RRD, particularly among non-myopics. Further investigations on the role of hypertension and obesity are needed. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Farioli, A., Hemmingsson, T., Kriebel, D. Tags: Public health, Optic nerve, Retina, Optics and refraction Original articles - Clinical science Source Type: research

Predicting complications with pretreatment testing in infantile haemangioma treated with oral propranolol
Conclusions The predictive values of both protocols for the commonly observed adverse reactions are low. In this series, there is no evidence to suggest that routine pretreatment testing before propranolol initiation is of any value in otherwise healthy children. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 21, 2016 Category: Opthalmology Authors: Tang, L. Y., Hing, J. W., Tang, J. Y., Nishikawa, H., Shahidullah, H., Browne, F., Chikermane, A., Parulekar, M. Tags: Paediatrics Original articles - Clinical science Source Type: research