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Cytoplasmic and nuclear leptin expression in lacrimal gland tumours: a pilot study
Conclusions The leptin concentration in tears was greater in patients with ACC than in those with PA. Leptin nuclear staining was only observed in the ACC tissue. Further investigations should be conducted to identify the cause and significance of these findings. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Kim, Y. J., Kim, Y. S., Chin, S., Yoon, J. S., Lee, S. Y., Kim, C. Y., Jang, S. Y. Tags: Lacrimal gland, Tears Original articles - Laboratory science Source Type: research

The association between toll-like receptor 4 polymorphisms and diabetic retinopathy in Chinese patients with type 2 diabetes
Conclusions This study suggested that rs1927914 and rs1927911 were associated with type 2 diabetes mellitus and that rs1927914 was associated with susceptibility to DR in a Han Chinese population. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Xu, Y., Jiang, Z., Huang, J., Meng, Q., Coh, P., Tao, L. Tags: Retina Original articles - Laboratory science Source Type: research

Effect of mitomycin-C on contraction and migration of human nasal mucosa fibroblasts: implications in dacryocystorhinostomy
Conclusions MMC successfully inhibited TGF-β1-induced myofibroblast transformation, collagen gel contraction and significantly reduced the migration of HNMFs to cover the wound even at a low concentration of 0.2 mg/mL. This study provides evidence that low concentration and short duration of MMC treatment is efficient in reducing increased contraction and migration of HMNFs in response to injury. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Kumar, V., Ali, M. J., Ramachandran, C. Tags: Ophthalmologic surgical procedures Original articles - Laboratory science Source Type: research

Reticular drusen in eyes with high-risk characteristics for progression to late-stage age-related macular degeneration
Conclusions Careful and meticulous analysis using three-dimensional in vivo imaging reveals distinct characteristic RDR patterns underlying detectable dynamic changes over a period of 2 years. RDR in eyes with early or intermediate AMD are a common observation but appear to be overall less common compared with eyes with geographic atrophy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Steinberg, J. S., Gobel, A. P., Fleckenstein, M., Holz, F. G., Schmitz-Valckenberg, S. Tags: Retina Original articles - Clinical science Source Type: research

Aflibercept therapy for polypoidal choroidal vasculopathy: short-term results of a multicentre study
Conclusions IAIs for the treatment of a large number of PCV eyes were found to improve both visual acuity and macular morphology over the short term. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Koizumi, H., Kano, M., Yamamoto, A., Saito, M., Maruko, I., Sekiryu, T., Okada, A. A., Iida, T. Tags: Choroid Original articles - Clinical science Source Type: research

Significance of the hyperautofluorescent ring associated with choroidal neovascularisation in eyes undergoing anti-VEGF therapy for wet age-related macular degeneration
Conclusions Nearly 40% of wet AMD eyes had an HAF ring. In treatment-naive eyes, the HAF ring had a significant association with SRF and was found as early as the baseline measurement and as long as 18 months after beginning treatment, persisting for up to 6 years after the initial diagnosis. Its association with baseline SRF and disruption of the ellipsoid zone line of the photoreceptors on OCT could indicate continuous stress on the outer retinal structures after exposure to prolonged SRF and/or transmitted autofluorescence from loss of the photoreceptors overlying the retinal pigment epithelium. (Source: Briti...
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Camacho, N., Barteselli, G., Nezgoda, J. T., El-Emam, S., Cheng, L., Bartsch, D.-U., Freeman, W. R. Tags: Choroid, Retina, Editor's choice Original articles - Clinical science Source Type: research

Comparison of intravitreal bevacizumab and dexamethasone implant for the treatment of macula oedema associated with branch retinal vein occlusion
Conclusions For macular oedema secondary to BRVO, IVB administered PRN monthly and IVD administered PRN at 6-month intervals, yielded functionally and anatomically comparable outcomes at 12 months. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Kim, M., Lee, D. H., Byeon, S. H., Koh, H. J., Kim, S. S., Lee, S. C. Tags: Retina Original articles - Clinical science Source Type: research

Ranibizumab for subfoveal choroidal neovascularisation associated with Stargardt disease
Conclusions Ranibizumab treatment can stop the CNV progression, but cannot ensure a significant visual improvement. Macular atrophy tends to significantly enlarge under ranibizumab treatment over the follow-up. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Battaglia Parodi, M., Munk, M. R., Iacono, P., Bandello, F. Tags: Choroid, Retina Original articles - Clinical science Source Type: research

En face swept-source optical coherence tomography in neovascular age-related macular degeneration
Conclusions En face SS-OCT is a rapid, non-invasive, high-resolution, promising technology, which allows a complementary study to angiography of neovascular AMD. There is a correlation between angiography and en face SS-OCT images in neovascular AMD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Flores-Moreno, I., Arias-Barquet, L., Rubio-Caso, M. J., Ruiz-Moreno, J. M., Duker, J. S., Caminal, J. M. Tags: Retina Original articles - Clinical science Source Type: research

Changes in choroidal thickness during pregnancy detected by enhanced depth imaging optical coherence tomography
Conclusions Choroidal thickness was found to be significantly decreased in healthy pregnant women during the third trimester compared to the first trimester. This finding can provide valuable information when interpreting pregnancy related ocular disorders. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Dadaci, Z., Alptekin, H., Oncel Acir, N., Borazan, M. Tags: Epidemiology Original articles - Clinical science Source Type: research

Usability of prostaglandin monotherapy eye droppers
Conclusions Prostaglandin monotherapy droppers for glaucoma treatment vary in their resistance to extract a drop and with some a drop could not be comfortably achieved by half the population, which may affect compliance and efficacy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Drew, T., Wolffsohn, J. S. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Protocol-driven adjustment of ocular hypotensive medication in patients at low risk of conversion to glaucoma
Conclusions Nearly half (43.9%) of low-risk OH eyes in this setting could safely reduce medications over 1 year, realising substantial savings. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Chan, P. P. M., Leung, C. K. S., Chiu, V., Gangwani, R., Sharma, A., So, S., Congdon, N. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Do pattern deviation values accurately estimate glaucomatous visual field damage in eyes with glaucoma and cataract?
Conclusions Clinicians should be very careful when reviewing the VF of a patient with glaucoma and cataract since PD values may underestimate glaucomatous VF damage in patients with advanced disease and also overestimate glaucomatous VF damage in patients with early to moderate cataract. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Matsuda, A., Hara, T., Miyata, K., Matsuo, H., Murata, H., Mayama, C., Asaoka, R. Tags: Angle, Intraocular pressure, Lens and zonules, Glaucoma Original articles - Clinical science Source Type: research

Choosing two points to add to the 24-2 pattern to better describe macular visual field damage due to glaucoma
Conclusions Adding a pair of locations to the superior macular region of the Humphrey Visual Field 24-2 pattern increases the number of abnormal locations identified in individuals with glaucoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Chen, S., McKendrick, A. M., Turpin, A. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

The relationship between structure and function as measured by OCT and Octopus perimetry
Conclusions Retinal sensitivity evaluated with OP correlated moderately well with the RNFL thickness measured by OCT. There was an overlap of the visual field regions within the optic disc. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Monsalve, B., Ferreras, A., Khawaja, A. P., Calvo, P., Ara, M., Fogagnolo, P., Iester, M. Tags: Angle, Intraocular pressure, Optic nerve, Neurology, Glaucoma Original articles - Clinical science Source Type: research

Combining measurements from three anatomical areas for glaucoma diagnosis using Fourier-domain optical coherence tomography
Conclusions Combining structural measurements of GCC, NFL and disc variables from FD-OCT created a GSDI that improved the accuracy for glaucoma diagnosis. Trial registration number NCT01314326. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Loewen, N. A., Zhang, X., Tan, O., Francis, B. A., Greenfield, D. S., Schuman, J. S., Varma, R., Huang, D., for the Advanced Imaging for Glaucoma Study Group Tags: Angle, Intraocular pressure, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Cupping of the optic disk after methanol poisoning
Conclusions Optic disk cupping after methanol poisoning may be more common than previously recognised. Cupping in this setting may reflect toxicity of methanol metabolites to axons and glial cells in the prelaminar, laminar and retrolaminar regions, and seems to be important as a marker for worse optic nerve damage. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Galvez-Ruiz, A., Elkhamary, S. M., Asghar, N., Bosley, T. M. Tags: Original articles - Clinical science Source Type: research

Syphilitic uveitis and optic neuritis in Sydney, Australia
Conclusions The clinical findings of 37 eyes with ocular syphilis demonstrated a broad spectrum of clinical manifestations. Rates of HIV coinfection were high, with patients exhibiting both anterior and posterior segment inflammation. Visual outcome improved following syphilis treatment. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Northey, L. C., Skalicky, S. E., Gurbaxani, A., McCluskey, P. J. Tags: Choroid, Optic nerve, Retina, Neurology Original articles - Clinical science Source Type: research

Posterior subtenon triamcinolone acetonide injection as a primary treatment in eyes with acute Vogt-Koyanagi-Harada disease
Conclusions This study demonstrated that isolated STI therapy is a useful, minimally invasive, primary treatment option for patients with acute VKH without systemic disorders. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Hosoda, Y., Hayashi, H., Kuriyama, S. Tags: Choroid, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Late in-the-bag intraocular lens dislocation in patients with uveitis
Conclusions IOL dislocation is an uncommon late complication in patients with uveitis. Conservative management is appropriate in patients with tolerable symptoms, or in those with difficult uveitis. Otherwise, fixation of the existing IOL, or removal and implantation of a secondary IOL, may be necessary. Angle-supported, or iris-enclaved IOLs, are not of proven safety in this patient group; scleral-fixated posterior chamber IOLs are the favoured approach in our service. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Steeples, L. R., Jones, N. P. Tags: Ophthalmologic surgical procedures, Lens and zonules, Optic nerve, Optics and refraction Original articles - Clinical science Source Type: research

Anterior chamber gas bubble emergence pattern during femtosecond LASIK-flap creation
Conclusions The migration of gas bubbles into the AC is a rare occurrence during femtosecond laser flap creation. The preferential emergence of gas bubbles into the nasal and inferior quadrants of the AC may indicate a distinctive anatomy of the nasal Schlemm's canal. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Robert, M.-C., Khreim, N., Todani, A., Melki, S. A. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Large-diameter deep anterior lamellar keratoplasty for keratoconus: visual and refractive outcomes
Conclusions L-DALK can reduce the degree of postoperative myopia and manifest astigmatism and improve visual acuity outcomes in keratoconus compared with S-DALK. Trial registration number Chinese Clinical Trial Registry (TRC-13003122). (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Huang, T., Hu, Y., Gui, M., Zhang, H., Wang, Y., Hou, C. Tags: Ophthalmologic surgical procedures, Cornea, Ocular surface, Optic nerve, Optics and refraction Original articles - Clinical science Source Type: research

Re-appraisal of topical 1% voriconazole and 5% natamycin in the treatment of fungal keratitis in a randomised trial
Conclusions When compared with voriconazole, natamycin was more effective in the treatment of fungal keratitis, especially Fusarium keratitis. Trial registration number: Clinical Trial Registry India (2010/091/003041). (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Sharma, S., Das, S., Virdi, A., Fernandes, M., Sahu, S. K., Kumar Koday, N., Ali, M. H., Garg, P., Motukupally, S. R. Tags: Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Sensitivity and specificity of the AdenoPlus point-of-care system in detecting adenovirus in conjunctivitis patients at an ophthalmic emergency department: a diagnostic accuracy study
Conclusions The AdenoPlus test has a high specificity for diagnosing adenoviral conjunctivitis, but in this clinical setting, we could not reproduce the high sensitivity that has been previously published. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Kam, K. Y. R., Ong, H. S., Bunce, C., Ogunbowale, L., Verma, S. Tags: Conjunctiva, Ocular surface Original articles - Clinical science Source Type: research

Aqueous penetration of orally and topically administered moxifloxacin
Conclusions Moxifloxacin has an impressive spectrum of coverage and this pharmacokinetic study reinforces its potential as a prophylactic drug against intraocular infections, given the high aqueous levels post topical administration. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Sharma, T., Kamath, M. M., Kamath, M. G., Nayak, R. R., Bairy, K. L., Musmade, P. B. Tags: Choroid, Eye (globe), Lens and zonules Original articles - Clinical science Source Type: research

Comparison of central and peripheral corneal thickness measurements with scanning-slit, Scheimpflug and Fourier-domain ocular coherence tomography
Conclusions There are significant clinically relevant differences between regional and relational thickness measurements obtained with ultrasound, scanning-slit, Scheimpflug and OCT devices. Screening metrics devised for one system do not appear directly applicable to other measurement systems. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Randleman, J. B., Lynn, M. J., Perez-Straziota, C. E., Weissman, H. M., Kim, S. W. Tags: Epidemiology Original articles - Clinical science Source Type: research

Ophthalmic grading of facial paralysis: need for a closer look
Very many variations of facial grading systems have been developed, but none address the ophthalmic complications of facial nerve weakness adequately. The important priorities for ophthalmic surgeon are protecting the ocular surface, maintaining sight and peripheral vision, as well as improving the cosmesis of periocular area. The absence of a universally agreed grading system on the ophthalmic plastic complications of facial nerve paralysis is an obstacle to standardised treatment. It is time for clinicians to recognise this need. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Ziahosseini, K., Nduka, C., Malhotra, R. Tags: Neurology Review Source Type: research

Ophthalmic statistics note 5: diagnostic tests--sensitivity and specificity
This is the fifth statistics note produced by the Ophthalmic Statistics Group (OSG) which is designed to be a simple guide to ophthalmic researchers on a statistical issue with an applied ophthalmic example. The OSG is a collaborative group of statisticians who have come together with a desire to raise the statistical standards of ophthalmic researcher by increasing statistical awareness of common issues. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Saunders, L. J., Zhu, H., Bunce, C., Dore, C. J., Freemantle, N., Crabb, D. P., on behalf of the Ophthalmic Statistics Group, This fifth note from the Ophthalmic Statistics Group illustrates the utility of measurements of sensitivity and specificity in as Tags: Open access Review Source Type: research

3D printed reproductions of orbital dissections: a novel mode of visualising anatomy for trainees in ophthalmology or optometry
Discussion These 3D prints offer many advantages over plastinated specimens as they are suitable for rapid reproduction and as they are not human tissue they avoid cultural and ethical issues associated with viewing cadaver specimens. In addition, they are suitable for use in the office, home, laboratory or clinical setting in any part of the world for patient and doctor education. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Adams, J. W., Paxton, L., Dawes, K., Burlak, K., Quayle, M., McMenamin, P. G. Tags: Innovations Source Type: research

The treatment of carcinoma in situ and squamous cell carcinoma of the conjunctiva with fractionated strontium-90 radiation in a population with a high prevalence of HIV
Conclusions Sr-90 brachytherapy is safe and effective in preventing recurrences in ocular surface squamous neoplasia in a high HIV prevalent setting. The 18 mm plaque size is superior to the 8.5 mm plaque size. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Lecuona, K., Stannard, C., Hart, G., Rice, J., Cook, C., Wetter, J., Duffield, M. Tags: Optic nerve, Optics and refraction Global issues Source Type: research

Ophthalmic statistics note 7: multiple hypothesis testing--to adjust or not to adjust
Defining the problem Investigating multiple research questions, or hypotheses, within one study is a common scenario in biomedical research with many examples in ophthalmology. As the number of statistical tests increases, the overall chance that we draw an erroneous conclusion in our study gets higher in a predictable manner. Each statistical test conducted at the conventional 5% significance level (α) has a one in 20 chance (or 0.05 probability) of appearing significant simply due to chance (a type I error) and a 1–0.05=0.95 probability of being non-significant. If we test two independent true null hypotheses...
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Cipriani, V., Quartilho, A., Bunce, C., Freemantle, N., Dore, C. J., on behalf of the Ophthalmic Statistics Group, on behalf of the Ophthalmic Statistics Group, Cook, Crabb, Cumberland, Czanner, Donachie, Elders, Finana, Nash, O'Leary, Rogers, Sivasubrama Tags: Retina, Epidemiology Editorials Source Type: research

Highlights from this issue
Randleman et al (see page 1176) There are significant, clinically relevant differences between regional and relational thickness measurements obtained with Ultrasound, scanning-slit, Scheimpflug, and OCT devices. Screening metrics devised for one system do not appear directly applicable to other measurement systems. Sharma et al (see page 1182) In a randomized clinical trial to determine the efficacy of topical voriconazole versus natamycin in the treatment of fungal keratitis, natamycin was more effective. Kamath et al (see page 1182) Aqueous penetration of topical moxifloxacin exceeds that following oral administration. ...
Source: British Journal of Ophthalmology - August 20, 2015 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

Correction
MacCallan M. Arthur Ferguson MacCallan: trachoma pioneer in Egypt 1903–1923. Br J Ophthalmol 2015;99:577–9. The Provenance and peer review statement should read: Commissioned; externally peer reviewed. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Tags: Corrections Source Type: research

No association between Bach2 gene polymorphisms with Vogt-Koyanagi-Harada syndrome (VKH) and Behcet's disease (BD) in a Chinese Han population
Conclusions The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either VKH or BD in our investigated Chinese Han population. Clinical trial registry This project was registered in the Chinese Clinical Trial Registry (registration number: ChiCTR-CCC-12002184). (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Gao, X., Tan, X., Qin, J., Lv, S., Hou, S., Kijlstra, A., Yang, P. Tags: Choroid, Neurology Original articles - Laboratory science Source Type: research

Dynamic changes of optical aberrations during restoration of optical properties of hydrophobic acrylic intraocular lens ejected through cartridge
Conclusions The dioptric power maps determined by the wavefront analyser can detect and follow the restoration of the optical properties of hydrophobic acrylic IOLs immediately after ejection. The restoration time was dependent on the temperature of the water chamber. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Uchida, A., Inoue, M., Bissen-Miyajima, H., Hirakata, A. Tags: Neurology Original articles - Laboratory science Source Type: research

Defining the ideal femtosecond laser capsulotomy
Conclusions Constructing the capsulotomy centred on the clinical approximation of the optical axis of the lens with diameter 5.25 mm optimises prevention of PCO, consistency of ELP and capsular strength. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Packer, M., Teuma, E. V., Glasser, A., Bott, S. Tags: Open access Original articles - Laboratory science Source Type: research

Prevalence of canaliculitis after smartplug insertion during long-term follow-up
Conclusions The late onset of complications after SmartPlug insertion requires long-term observation to identify the majority of complications associated with SmartPlugs. In our patients with a follow-up of up to 10.5 years, the use of SmartPlugs was associated with the highest prevalence of canaliculitis published thus far. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Klein-Theyer, A., Boldin, I., Rabensteiner, D. F., Aminfar, H., Horwath-Winter, J. Tags: Original articles - Clinical science Source Type: research

The clinical effectiveness of transcanalicular diode laser-assisted revision surgery for failed endoscopic endonasal dacryocystorhinostomy
Conclusions A diode laser can achieve effective tissue dissection with minimal damage and is a good alternative technique for patients with membranous obstruction who had a failed EDCR. However, it may not be appropriate for large granulomatous obstruction and sump syndrome. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Lee, J., Choi, S. Y., Lee, H., Chang, M., Park, M., Baek, S. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Dry eye symptoms align more closely to non-ocular conditions than to tear film parameters
Conclusions Dry eye symptoms more closely align to non-ocular pain, depression and PTSD than to tear film parameters. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Galor, A., Felix, E. R., Feuer, W., Shalabi, N., Martin, E. R., Margolis, T. P., Sarantopoulos, C. D., Levitt, R. C. Tags: Neurology, Epidemiology Original articles - Clinical science Source Type: research

Assessment of lower tear meniscus measurements obtained with Keratograph and agreement with Fourier-domain optical-coherence tomography
Conclusions Spectralis OCT LTMH measurements were more reliable than the new Keratograph data. Agreement between the devices was poor. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Arriola-Villalobos, P., Fernandez-Vigo, J. I., Diaz-Valle, D., Peraza-Nieves, J. E., Fernandez-Perez, C., Benitez-del-Castillo, J. M. Tags: Epidemiology Original articles - Clinical science Source Type: research

Influence of visual acuity on suicidal ideation, suicide attempts and depression in South Korea
Conclusions Low VA was associated with the occurrence of suicidal ideation or a suicide attempt. Ophthalmologists should embrace their responsibility to help reduce suicidality and prevent suicides in patients with low VA by encouraging them to seek psychiatric care. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Rim, T. H., Lee, C. S., Lee, S. C., Chung, B., Kim, S. S., Epidemiologic Survey Committee of the Korean Ophthalmological Society Tags: Original articles - Clinical science Source Type: research

Association between penetrating eye injuries and attention deficit hyperactivity disorder in children
Conclusions There was an association between penetrating eye injuries and inattentiveness, hyperactivity, oppositional defiant disorder and conduct disorder in boys, and conduct disorder in girls. An appropriate evaluation of ADHD symptoms may prevent vision loss due to penetrating eye injuries in children. In addition, evaluation by a child psychiatrist of children presenting with penetrating eye injuries may prevent repetition of injuries. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Bayar, H., Coskun, E., Oner, V., Gokcen, C., Aksoy, U., Okumus, S., Erbagci, I. Tags: Paediatrics, Public health Original articles - Clinical science Source Type: research

The mental health of UK ex-servicemen with a combat-related or a non-combat-related visual impairment: does the cause of visual impairment matter?
Conclusions Mental health problems were prevalent among visually impaired younger ex-servicemen. No statistically significant differences were found in the prevalence of mental health problems among ex-servicemen with a combat-related visual impairment compared with those with a non-combat-related visual impairment. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Stevelink, S. A. M., Malcolm, E. M., Gill, P. C., Fear, N. T. Tags: Open access, Epidemiology Original articles - Clinical science Source Type: research

Changes in anterior segment dimensions over 4 years in a cohort of Singaporean subjects with open angles
Conclusions Angle width significantly decreased; ICURV and LV increased in subjects with gonioscopically open angles followed at 4 years. Eyes with shorter AxL and greater ICURV at baseline had lesser decrease in angle width. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: He, Y., Baskaran, M., Narayanaswamy, A. K., Sakata, L. M., Wu, R., Liu, D., Nongpiur, M. E., He, M., Friedman, D. S., Aung, T. Tags: Original articles - Clinical science Source Type: research

Gonioscopy assisted transluminal trabeculotomy: an ab interno circumferential trabeculotomy for the treatment of primary congenital glaucoma and juvenile open angle glaucoma
Conclusions The preliminary results and safety for GATT, a minimally invasive conjunctival sparing circumferential trabeculotomy, are promising and at least equivalent to previous results for ab externo trabeculotomy for the treatment of PCG and JOAG. All eyes in the study were considered a clinical success. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Grover, D. S., Smith, O., Fellman, R. L., Godfrey, D. G., Butler, M. R., Montes de Oca, I., Feuer, W. J. Tags: Paediatrics, Angle, Anterior chamber, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Six-month results of intravitreal aflibercept injections for patients with polypoidal choroidal vasculopathy
Conclusions At 6 months, aflibercept monotherapy effectively reduced polyps, retinal exudation and CRT in patients with PCV. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Hosokawa, M., Shiraga, F., Yamashita, A., Shiragami, C., Ono, A., Shirakata, Y., Kimura, S., Shiode, Y., Kawata, T., Hosogi, M., Fujiwara, A., Morizane, Y. Tags: Choroid Original articles - Clinical science Source Type: research

Progressing geographic atrophy: choroidal thickness and retinal sensitivity identify two clinical phenotypes
Conclusions During follow-up, changes in Se and choroidal thickness differed in patients with GA with or without CNV in the fellow eye. These results identify at least two GA phenotypes, in which the development and progression of GA may be primarily due to different pathophysiologic mechanisms. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Pilotto, E., Guidolin, F., Convento, E., Stefanon, F. G., Parrozzani, R., Midena, E. Tags: Choroid Original articles - Clinical science Source Type: research

Prevalence of vitreomacular interface abnormalities on spectral domain optical coherence tomography of patients undergoing macular photocoagulation for centre involving diabetic macular oedema
Conclusions ERM or pVMS was found on SD-OCT scanning in 25% of patients undergoing laser for centre involving DME. In 20% of all patients, these potentially tractional elements were either present in the central subfield scan or the traction was contiguous with the central macular thickening, suggesting a possible role for surgical or enzymatic relief of traction in their management. This requires targeted investigation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Akbar Khan, I., Mohamed, M. D., Mann, S. S., Hysi, P. G., Laidlaw, D. A. Tags: Ophthalmologic surgical procedures, Retina Original articles - Clinical science Source Type: research

Long-term efficacy of half-dose photodynamic therapy on chronic central serous chorioretinopathy
Conclusions PDT with half-dose verteporfin has a long-term efficacy and safety profile in chronic CSC. However, complications may still happen despite the reduced dosage. Trial registration number The CCH IRB No. 131007. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Tseng, C.-C., Chen, S.-N. Tags: Original articles - Clinical science Source Type: research

Effects of posterior vitreous detachment on aqueous humour levels of VEGF and inflammatory cytokines
Conclusions PVD is related to the change in the multiple intraocular inflammatory cytokines. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2015 Category: Opthalmology Authors: Takahashi, H., Nomura, Y., Tan, X., Fujino, Y., Kawashima, H., Yanagi, Y. Tags: Lens and zonules, Vitreous Original articles - Clinical science Source Type: research