Medicine RSS Search Engine

British Journal of Ophthalmology

This page shows you the latest items in this publication.

Re: Ang et al: Descemet's stripping automated endothelial keratoplasty with anterior chamber intraocular lenses: complications and 3-year outcomes
Dear editor, We read with interest the article titled ‘Descemet's stripping automated endothelial keratoplasty with anterior chamber intraocular lenses: complications and 3-year outcomes’ by Ang et al.1 Although the authors concluded that endothelial cell loss and graft survival in anterior chamber intraocular lens (ACIOL) group were significantly poorer compared with Descemet's stripping automated endothelial keratoplasty (DSAEK) controls at 3 years postoperatively, we would like to draw attention to following issues:Though the title of the article stated that it was a ‘3-year’ outcome study, ...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Mittal, R., Garg, P. Tags: Letters Source Type: research

Correction
Tang J, Herda AA, and Kern TS. Photobiomodulation in the treatment of patients with non-centerinvolving diabetic macular oedema. Br J Ophthalmol 2014;98:1013–5. The article states that the daily dose of light administered was 25 J/cm2; however the actual dose per treatment was 9 J/cm2. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Tags: Corrections Source Type: research

Descemet's stripping automated endothelial keratoplasty with anterior chamber intraocular lenses
Dear Editor, We thank Mittal and Garg for their interest in our publication. Our study analysed Descemet's stripping automated endothelial keratoplasty (DSAEK) with anterior chamber intraocular lenses (ACIOL) with regards to 3-year graft survival and endothelial cell loss as our main outcome measures, not visual outcome or complications.1 Here, we used Kaplan–Meier survival analysis that takes into account any censored data from loss to follow-up, to derive that there was a significantly poorer graft survival in the DSAEK-ACIOL group versus the DSAEK group (log-rank p=0.002). In fact, completely excluding subjects wi...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Tan, D., Htoon, H. M., Ang, M. Tags: Letters Source Type: research

Two novel mutations including a large deletion of the SLC4A11 gene causing autosomal recessive hereditary endothelial dystrophy
Introduction Congenital hereditary endothelial dystrophy (CHED) is an inherited disorder of the corneal endothelium characterised by bilateral non-inflammatory corneal clouding ranging from a diffuse haze to a ground-glass appearance. CHED can be inherited in an autosomal dominant (CHED1) or recessive (CHED2) manner. CHED2 usually presents at birth or early infancy. Bilateral corneal clouding can lead to visual impairment often accompanied by nystagmus in CHED2 patients requiring corneal transplantation.1 Mutations in the solute carrier family 4 member 11 (SLC4A11) gene have been identified in most patients with CHED2. Wit...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Puangsricharern, V., Yeetong, P., Charumalai, C., Suphapeetiporn, K., Shotelersuk, V. Tags: Letters Source Type: research

Novel mitochondrial tRNAIle m.4282A>G gene mutation leads to chronic progressive external ophthalmoplegia plus phenotype
Conclusions We describe a novel MTTI transition mutation at nucleotide position m.4282G>A associated with a CPEO plus phenotype. The novel variant at position m.4282G>A disrupts the middle bond of the D-stem of the tRNAIle and is highly conserved. The conservation and phenotype-genotype segregation strongly suggest pathogenicity and is in good agreement with the MTTI gene being frequently associated with CPEO. This novel variant broadens the spectrum of MTTI mutations causing CPEO. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Jackson, C. B., Neuwirth, C., Hahn, D., Nuoffer, J.-M., Frank, S., Gallati, S., Schaller, A. Tags: Muscles, Neurology Original articles - Laboratory science Source Type: research

Effects of aflibercept on primary RPE cells: toxicity, wound healing, uptake and phagocytosis
Conclusions Aflibercept interferes with the physiology of RPE cells, as it is taken up into RPE cells, which is accompanied by a reduction of the phagocytic ability. Additionally, it impairs the wound healing capacity of RPE cells. These effects on the physiology of RPE cells may indicate possible side effects. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Klettner, A., Tahmaz, N., Dithmer, M., Richert, E., Roider, J. Tags: Retina, Editor's choice Original articles - Laboratory science Source Type: research

Eyelash line resection for cilial entropion in patients with Down's syndrome
Conclusions Eyelash line resection is a simple and effective technique for cilial entropion and medial epiblepharon in patients with Down's syndrome. The surgery improves the SPK and frequency of spectacle wear. Trial registration number NCT01758718. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Suzuki, Y., Hama, Y., Yoshikawa-Kobayashi, I., Tomita, K., Inoue, M., Hirakata, A. Tags: Cornea, Eye Lids, Ocular surface, Neurology Original articles - Clinical science Source Type: research

Medial lower lid epiblepharon repair solely by skin-redraping medial epicanthoplasty
Conclusions For patients with medial lower lid epiblepharon with epicanthal fold without excessive skin and muscle, a simple skin-redraping medial epicanthoplasty without traditional epiblepharon correction methods showed good results of epiblepharon repair. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Oh, J., Lee, K. Tags: Original articles - Clinical science Source Type: research

Management of congenital lacrimal (anlage) fistula
Conclusions Congenital lacrimal fistulae may be successfully treated with simple excision alone in most cases. Adjunctive DCR or intubation can be reserved for those identified to have lacrimal outflow tract abnormalities. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Al-Salem, K., Gibson, A., Dolman, P. J. Tags: Ophthalmologic surgical procedures, Neurology Original articles - Clinical science Source Type: research

Clinical outcomes of sleeveless phacotip assisted levitation of dropped nucleus
Conclusion Dropped nucleus was successfully levitated into anterior chamber with this technique, resulting in a significant visual outcome with a favourable complication rate. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Agarwal, A., Narang, P., A Kumar, D., Agarwal, A. Tags: Cornea, Ocular surface, Retina Original articles - Clinical science Source Type: research

Results of late surgical intervention in children with early-onset bilateral cataracts
Conclusions and relevance Our results demonstrate that not only can significant vision be acquired until late in childhood, but that neural processes underlying even basic aspects of vision like resolution acuity remain malleable until at least adolescence. These data argue for the provision of cataract treatment to all children, irrespective of their age. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Ganesh, S., Arora, P., Sethi, S., Gandhi, T. K., Kalia, A., Chatterjee, G., Sinha, P. Tags: Paediatrics, Ophthalmologic surgical procedures, Lens and zonules, Vision, Neurology, Visual development Original articles - Clinical science Source Type: research

Traditional and reduced recession surgical dosage for bilateral lateral rectus recession for infantile exotropia
Conclusions Postoperative surgical outcome was not affected by a reduction in the amount of recession by 1–2 mm from traditional tables used for treatment of exotropia. Reducing the recession of the lateral recti reduces the risk of overcorrection in this sensory labile population. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Nam, K.-T., Kim, S.-H. Tags: Paediatrics, Muscles, Neurology Original articles - Clinical science Source Type: research

Factors associated with the angle of exodeviation in patients with recurrent exotropia
Conclusions Although the overall incidence of recurrent exotropia with a relatively large angle (LAAR≥PA) is low among patients who underwent surgery for exotropia (2.5%), the possibility of this phenomenon should be noted. The ratio of relatively large angle recurrence was higher in patients with a small preoperative exodeviation and basic type exotropia. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Lee, B. J., Kim, S.-J., Yu, Y. S. Tags: Muscles, Neurology Original articles - Clinical science Source Type: research

Comparison of different surgery procedures for convergence insufficiency-type intermittent exotropia in children
Conclusions The improved R&R procedure in which medial rectus resection based on the near deviation with lateral rectus recession based on the distant deviation has a better alignment than the UMR and BMR surgeries for the treatment of children with CI-type IXT. All the UMR, BMR and improved R&R surgery can reduce near-distance differences in children with CI-type IXT. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Wang, B., Wang, L., Wang, Q., Ren, M. Tags: Paediatrics, Muscles, Neurology Original articles - Clinical science Source Type: research

Lateral incomitancy and surgical results in intermittent exotropia
Conclusions Surgical outcomes in ULR and BLR for intermittent exotropia correction showed no association with preLI+. The prevalences of significant LI were unchanged after surgery in both groups. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Yoon, C. H., Kim, S.-J. Tags: Muscles, Neurology Original articles - Clinical science Source Type: research

The relationship between preoperative and postoperative near stereoacuities and surgical outcomes in intermittent exotropia
Conclusions Classification of IXT based on the degree of near stereopsis offers a useful tool for the assessment of initial sensory status as well as postoperative prognosis. Also, a lower age at first detection of IXT and a lower best-corrected visual acuity were associated with poor near stereoacuity. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Lee, D. S., Kim, S.-J., Yu, Y. S. Tags: Muscles, Neurology Original articles - Clinical science Source Type: research

Gaze and pupil changes during navigation in age-related macular degeneration
Conclusions Fixation count is a marker of difficult navigational environments in patients with AMD. The combination of video projection and eye tracking to assess visual navigation function is a useful clinical tool and an adjunct to current investigation tools in AMD intervention studies providing objective clinical measures under standardised settings. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Aspinall, P. A., Borooah, S., Al Alouch, C., Roe, J., Laude, A., Gupta, R., Gupta, M., Montarzino, A., Dhillon, B. Tags: Retina Original articles - Clinical science Source Type: research

Relationship between halo size and forward light scatter
Conclusions In healthy eyes, the larger the halo size induced by a given glare source, the greater the forward-scatter (straylight) and worse the mesopic LC-VA. Halo size seems to be independent of photopic HC-VA or LC-VA and mesopic HC-VA. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Puell, M. C., Perez-Carrasco, M. J., Palomo-Alvarez, C., Antona, B., Barrio, A. Tags: Original articles - Clinical science Source Type: research

Estimation of the effects of rounding visual acuity data
Conclusions Rounding of visual acuity scores is an important potential bias in outcome data and should be avoided. If rounding is required we recommend that it is carried out conservatively, giving credit only for lines read completely. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Frost, N. A., Brooks, S., Myerscough, J. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Orbital aspergillosis in immunocompetent patients
Conclusions Though orbital aspergillosis is commonly seen in immunocompromised patients, it should be suspected in young immunocompetent individuals presenting with proptosis of insidious onset and infiltrating lesions involving the paranasal sinuses. Definitive diagnosis is achieved by histopathological and microbiological evaluation. Systemic steroids should be avoided prior to definitive diagnosis. Prolonged systemic antifungal therapy with an option of additional debulking of lesions provides good disease control with improved survival. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Mody, K. H., Ali, M. J., Vemuganti, G. K., Nalamada, S., Naik, M. N., Honavar, S. G. Tags: Orbit Original articles - Clinical science Source Type: research

Central retinal venous pulsation pressure in different stages of primary open-angle glaucoma
Conclusions In more advanced cases of glaucoma, CRVPP seems to be much higher than previously thought. This might further compromise the perfusion pressure in the prelaminar region of the optic nerve head and be of clinical importance, especially in IOP-controlled more advanced cases. This should be considered as a possible risk factor for progression. Trial registration number ClinicalTrials.gov ID: NCT01503996. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Pillunat, K. R., Ventzke, S., Spoerl, E., Furashova, O., Stodtmeister, R., Pillunat, L. E. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis
Conclusions Based on OCT angiography, the FI measurement is feasible, highly repeatable and reproducible, and it is suitable for clinical measurement of ONH and parafoveal perfusion. The ONH FI may be useful in detecting damage from ON and quantifying its severity. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Wang, X., Jia, Y., Spain, R., Potsaid, B., Liu, J. J., Baumann, B., Hornegger, J., Fujimoto, J. G., Wu, Q., Huang, D. Tags: Optic nerve, Neurology Original articles - Clinical science Source Type: research

Clinical and demographic associations with optic nerve hypoplasia in New Zealand
Conclusions This is the first major study of visual impairment in New Zealand children, and it demonstrates that ONH is an important cause of severe visual disability; with an over-representation of Maori children and younger maternal age. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Goh, Y. W., Andrew, D., McGhee, C., Dai, S. Tags: Paediatrics, Vision, Neurology Original articles - Clinical science Source Type: research

Visual outcomes of surgical intervention for pseudotumour cerebri: optic nerve sheath fenestration versus cerebrospinal fluid diversion
Conclusions Visual acuity and MD improved after ONSF and shunt procedures in patients with severe vision loss from PTC and papilloedema. Improvement of MD in both groups was of the same magnitude (6 dB), but because the two groups were not entirely comparable, prospective comparison of the two procedures is required to establish the relative efficacy of each procedure. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Fonseca, P. L., Rigamonti, D., Miller, N. R., Subramanian, P. S. Tags: Optic nerve, Neurology Original articles - Clinical science Source Type: research

Treatment outcome of osteosarcoma after bilateral retinoblastoma: a retrospective study of eight cases
Conclusions Our data could be used as a basis for future studies aimed at reaching consensus about long term follow-up and treatment guidelines for this genetically susceptible group of patients. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Lee, J. A., Choi, S. Y., Kang, H. J., Lee, J. W., Kim, H., Kim, J. H., Sung, K. W., Shin, H. Y., Ahn, H. S., Park, K. D. Tags: Original articles - Clinical science Source Type: research

High dose rate and low dose rate ruthenium brachytherapy for uveal melanoma. No association with ocular outcome
Conclusions Although dose rates ranged widely, there was no apparent association with secondary enucleation, suggesting that based on ocular survival, current practice of annual replacement of applicators is acceptable, irrespective of the significant reduction in each applicator's dose rate. Nevertheless, patients treated with higher dose rates have shorter plaque exposure and presumably less ocular irritation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Fili, M., Lundell, G., Lundell, M., Seregard, S. Tags: Original articles - Clinical science Source Type: research

Quantification of cone loss after surgery for retinal detachment involving the macula using adaptive optics
Conclusions There was a decrease in the cone density after RD with an estimated loss of one-third of the cones. Postoperative visual acuity was highly correlated with the cone density. AO may be a valuable prognostic tool after RD surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Saleh, M., Debellemaniere, G., Meillat, M., Tumahai, P., Bidaut Garnier, M., Flores, M., Schwartz, C., Delbosc, B. Tags: Retina Original articles - Clinical science Source Type: research

Risk factors for postoperative complications in lensectomy-vitrectomy with or without intraocular lens placement in ectopia lentis associated with Marfan syndrome
Conclusions Development of RD in patients with Marfan syndrome remains a risk following surgery for ectopia lentis. Caution should be taken in eyes with severe lens dislocation or high axial myopia when planning the surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Fan, F., Luo, Y., Liu, X., Lu, Y., Zheng, T. Tags: Ophthalmologic surgical procedures, Eye (globe), Lens and zonules, Optic nerve, Retina, Optics and refraction Original articles - Clinical science Source Type: research

Visual acuity and central retinal thickness: fulfilment of retreatment criteria for recurrent neovascular AMD in routine clinical care
Conclusions In a routine clinical care, evaluation of VA using ETDRS charts seems to be more sensitive than Snellen VA testing. Quantitative OCT-based retreatment criteria (eg, increase of CRT of 100 µm or more) appear to be not sensitive enough in a clinical setting with referring ophthalmologists. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Reznicek, L., Muhr, J., Ulbig, M., Kampik, A., Mayer, W. J., Haritoglou, C., Neubauer, A., Wolf, A. Tags: Retina Original articles - Clinical science Source Type: research

Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study
In this report, we describe the preliminary findings of the Determination of feasibility of Intraoperative Spectral domain microscope Combined/integrated OCT Visualisation during En face Retinal and ophthalmic surgery (DISCOVER) study, a multisurgeon investigational device study examining the role of microscope integrated iOCT systems with surgeon heads-up display feedback (eg, Carl Zeiss Meditec RESCAN 700, Cole Eye Institute iOCT prototype). During surgical manoeuvres in anterior segment and posterior segment surgery, this technology provides rapid visualisation of the area of interest and provides the surgeon with infor...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Ehlers, J. P., Kaiser, P. K., Srivastava, S. K. Tags: Innovations Source Type: research

Rethinking eye health systems to achieve universal coverage: the role of research
Achieving universal coverage in eye care remains a tremendous challenge as 226 million people in the world remain visually impaired, the majority from avoidable causes. The impact of eye care interventions has been constrained by the limited capacities of health systems in low-income and middle-income countries to deliver effective eye care services. Services for eye health are still not adequately integrated into the health systems of low-income and middle-income countries. We contend that radical rethinking and deeper development of eye health systems are necessary to achieve VISION 2020 goals. Responding to the challeng...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Blanchet, K., Gilbert, C., de Savigny, D. Tags: Open access Global issues Source Type: research

Managing antiplatelet and anticoagulant drugs in patients undergoing elective ophthalmic surgery
The management of antiplatelet and anticoagulant treatment can be challenging for the ophthalmic surgeon with the risk of impaired surgical view or potentially sight-threatening haemorrhage. With the advent of newer medications and the expanding usage of these drugs, there is a need for up-to-date guidance on the subject. This paper describes the current use of modern antiplatelet and anticoagulant drugs in the UK, and reviews the evidence of such treatments in the context of ophthalmic surgery. A multidisciplinary approach has been used to develop a guideline for the management of antiplatelet and anticoagulation treatmen...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Kiire, C. A., Mukherjee, R., Ruparelia, N., Keeling, D., Prendergast, B., Norris, J. H. Tags: Review Source Type: research

Intraocular pressure fluctuation and glaucoma progression: what do we know?
We present here the arguments made by both sides, as well as a discussion of the pitfalls of prior research and potential directions for future studies. Until a reliable method is developed that allows for constant IOP monitoring, many variables will continue to hinder us from drawing adequate conclusions regarding the significance of IOP variation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Leidl, M. C., Choi, C. J., Syed, Z. A., Melki, S. A. Tags: Angle, Intraocular pressure, Glaucoma Review Source Type: research

Modern-day cataract surgery: can we match growing expectations?
Cataract surgery has evolved from the ancient technique of ‘couching’ with suboptimal results to femtosecond laser-assisted phacoemulsification with excellent visual results. It is the most frequently performed surgery in the world.1 The recent advances in surgical techniques have increased the safety and efficacy of this procedure. There have also been improvements in the techniques to measure ocular biometry and methods to calculate intraocular lens (IOL) power resulting in high expectations for increasingly better outcomes from surgeons and patients. The accuracy of the refractive end point depends on the po...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Rana, M., Shah, S. Tags: Ophthalmologic surgical procedures, Lens and zonules, Optic nerve, Optics and refraction Editorials Source Type: research

Different techniques for performing DALK: are they making a real difference?
Penetrating keratoplasty (PKP) is a highly successful procedure in which full thickness cornea is replaced. Recent advancements in surgical techniques and instrumentation have shifted away from conventional PKP to Deep Anterior Lamellar Keratoplasty (DALK) performed by several forms of manual, microkeratome/femtosecond laser-assisted lamellar procedures. Deep anterior lamellar keratoplasty has been used as an alternative to PKP especially in keratoconus and corneal scarring1–4 with some advantages compared with PKP including reduced risk of intraoperative complications, elimination the risk of endothelial graft rejec...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Baradaran-Rafii, A., Hasani, H. Tags: Ophthalmologic surgical procedures, Cornea, Ocular surface, Optic nerve, Optics and refraction Editorials Source Type: research

Highlights from this issue
Chronic disease provides a huge burden on eye care resources. Blanchet et al1 discuss the challenges that will be required to achieve the goals of Vision 2020 (see page 1325). Wang et al2 report a prospective randomised trial in which they observed that in 45 children with convergency insufficiency-type intermittent exotropia, the success rate in terms of alignment at 6 months after surgery was significantly higher (87.5%) in the improved recess resect procedure (medial rectus resection based on the near deviation and lateral rectus recession based on the distant deviation) than in groups who underwent unilateral or bilate...
Source: British Journal of Ophthalmology - September 16, 2014 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

Quantitative assessment of central retinal thickness in recurrent neovascular age-related macular degeneration
We read with interest the article by Reznicek et al,1 which evaluated the fulfilment of retreatment criteria for recurrent neovascular age-related macular degeneration (AMD). We support the notion of qualitative optical coherence tomography (OCT) assessment of the retina. However, we will like to point out some factors that might have affected their conclusion that quantitative OCT-based retreatment criteria appeared not sensitive enough in a clinical setting. Reznicek et al1 mentioned that Stratus-OCT was used in the initial assessment of AMD; subsequently upon retreatment, the macula was assessed with spectral domain OCT...
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Chee Yee, C., Papakostas, T. D., Vavvas, D. G. Tags: Letters Source Type: research

On the origin of 'guttae'
Introduction The initial description of Fuchs’ endothelial corneal dystrophy (FECD) in 19101 was made without a slit-lamp biomicroscope and, thus, did not include ‘drop-like’ excrescences beneath the endothelium observed by Vogt in 1921 who is credited with coining the term ‘guttae’ (Latin for drops).2 The origin of gutta has remained obscure. Possible explanations could be that they arise as cellular secretions3 or as extrusions from weak areas in Descemet membrane (DM).4 Limited reports describe morphologies of guttae in FECD. Laing et al described five stages distinguished by size, abnormal...
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Son, H.-S., Villarreal, G., Meng, H., Eberhart, C. G., Jun, A. S. Tags: Letters Source Type: research

Morphologic alterations on posterior iris-claw intraocular lenses after traumatic disenclavation
Conclusions Traumatically dislocated iris-claw IOLs presented considerable alterations on the affected haptics, which might not guarantee a reliable re-enclavation. Therefore, we suggest an IOL replacement, instead of reenclavation, in cases of traumatic iris-claw disenclavation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Brockmann, T., Gonnermann, J., Brockmann, C., Torun, N., Joussen, A. M., Bertelmann, E. Tags: Original articles - Laboratory science Source Type: research

A prospective study of acute corneal hydrops by in vivo confocal microscopy in a New Zealand population with keratoconus
Conclusions Corneal neovascularisation occurred in 20% of eyes in this pilot study and prolonged presence of presumed inflammatory cells was observed in these eyes. Further study of this potential association may enable identification of patients at risk of neovascularisation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Lockington, D., Fan Gaskin, J. C., McGhee, C. N. J., Patel, D. V. Tags: Cornea, Ocular surface Original articles - Clinical science Source Type: research

Posterior iris-claw aphakic intraocular lens implantation and Descemet membrane endothelial keratoplasty
Conclusions DMEK and retropupillar iris-claw IOL implantation provide good visual outcomes with a fast visual recovery and appear to be a feasible method for the management of bullous keratopathy but with higher graft detachment rates. Trial registration number NCT02020044. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Gonnermann, J., Maier, A.-K. B., Klamann, M. K. J., Brockmann, T., Bertelmann, E., Joussen, A. M., Torun, N. Tags: Ophthalmologic surgical procedures, Angle, Cornea, Intraocular pressure, Ocular surface, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Fine needle diathermy occlusion of corneal vessels
Conclusions FND is effective in occluding established corneal vessels. Corneal microperforation is a potentially serious adverse event, but other adverse events, such as striae, whitening and intracorneal haemorrhages are reversible. It should be considered for established corneal vessels, and can be combined with antivascular endothelial growth factors. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Faraj, L. A., Elalfy, M. S., Said, D. G., Dua, H. S. Tags: Ophthalmologic surgical procedures, Cornea, Ocular surface Original articles - Clinical science Source Type: research

When case report became case series: 45 cases of late traumatic flap complications after laser-assisted in situ keratomileusis and review of Chinese literature
Conclusions Late traumatic flap complications after LASIK have become more frequent in China, although the prognosis of most cases is good. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Xiao, J., Jiang, C., Zhang, M., Jiang, H., Li, S., Zhang, Y., Li, Zhang Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Evaluation of a new optical biometry device for measurements of ocular components and its comparison with IOLMaster
Conclusions The repeatability and reproducibility of AL-Scan was excellent for all parameters, except WTW and PD. Excluding WTW, good agreement was found between the AL-Scan and IOLMaster. The 2.4-mm diameter K value may be the most reliable choice for calculation of IOL power with the AL-Scan. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Huang, J., Savini, G., Li, J., Lu, W., Wu, F., Wang, J., Li, Y., Feng, Y., Wang, Q. Tags: Lens and zonules Original articles - Clinical science Source Type: research

Cataract surgery outcomes in adult patients with Down's syndrome
Conclusions A high incidence of bilateral cataracts as well as white cataracts was observed in patients with Down's syndrome in our study. Although the surgical outcomes of cataract surgery were good, the visual outcomes were suboptimal in our cases due to associated ocular comorbidities. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Li, E. Y., Chan, T. C., Lam, N. M., Jhanji, V. Tags: Ophthalmologic surgical procedures, Angle, Cornea, Intraocular pressure, Lens and zonules, Ocular surface, Neurology, Glaucoma Original articles - Clinical science Source Type: research

Incidence of cystoid macular oedema in diabetic patients after phacoemulsification and free radical link to its pathogenesis
Conclusions The present results suggest that after phacoemulsification, the chance of development of CME in DR is more as compared to D. Moreover, the development of CME is significantly associated with decrease in antioxidant levels, increased ROS activities, hypertension, diabetic nephropathy, and hyperlipidaemia. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Samanta, A., Kumar, P., Machhua, S., Rao, G. N., Pal, A. Tags: Ophthalmologic surgical procedures, Lens and zonules, Retina Original articles - Clinical science Source Type: research

Cataract surgery in small adult eyes
Conclusions Microphthalmic eyes requiring high IOL power are rare, and their presence is often associated with other ocular congenital or acquired disorders. Overall, the clinical outcomes were satisfactory and the surgical procedure affected by a low complication rate. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Carifi, G., Safa, F., Aiello, F., Baumann, C., Maurino, V. Tags: Ophthalmologic surgical procedures, Eye (globe), Lens and zonules, Retina Original articles - Clinical science Source Type: research

Ocular adnexal lymphoma: validation of American Joint Committee on Cancer seventh edition staging guidelines
Conclusion AJCC seventh edition T category was predictive of DFS in patients with OAL. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Sniegowski, M. C., Roberts, D., Bakhoum, M., Mc Laughlin, P., Yin, V. T., Turturro, F., Esmaeli, B. Tags: Original articles - Clinical science Source Type: research

The impact of intermittent exotropia and surgery for intermittent exotropia on myopic progression among early school-aged children with myopia
Conclusions Whether patients with intermittent exotropia underwent surgical correction for intermittent exotropia did not influence the rate of myopic progression. There was no significant difference in the rate of myopic progression between patients with accompanying intermittent exotropia and myopia and those with myopia alone. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Shin, K. H., Hyun, S. H., Kim, I. N., Paik, H. J. Tags: Paediatrics, Muscles, Optic nerve, Neurology, Optics and refraction Original articles - Clinical science Source Type: research

In vivo analysis of the iris thickness by spectral domain optical coherence tomography
Conclusions SD-OCT is a suitable technique for iris thickness assessment. Thickness analysis must be carried out using a sectorial approach, taking into consideration anatomical variations existing between different iris regions. SD-OCT is a potentially useful tool for detecting iris thickness variations induced by pathological conditions such as Fuchs’ uveitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 18, 2014 Category: Opthalmology Authors: Invernizzi, A., Cigada, M., Savoldi, L., Cavuto, S., Fontana, L., Cimino, L., Aldigeri Tags: Original articles - Clinical science Source Type: research