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Drug candidate stops extra bone growth in animal model of rare, genetic disease
New preclinical research provides support to a drug that has been repurposed to possibly treat a rare and extremely disabling genetic bone disease, particularly in children. In that disease, fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, alters skeletal bone formation, and limits motion, breathing, and swallowing, among a host of progressive symptoms. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 13, 2016 Category: Science Source Type: news

Drug candidate halts crippling excess bone growth in animal model of a rare bone disease
(Children's Hospital of Philadelphia) New research in laboratory animals suggests that the drug palovarotene may prevent multiple skeletal problems caused by a rare but extremely disabling genetic bone disease, and may even be a candidate for use in newborn babies with the condition. Orthopedics researchers tested the drug candidate in mice carrying the human mutation that causes fibrodysplasia ossificans progressiva. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 13, 2016 Category: Global & Universal Source Type: news

Clementia completes patient enrolment in Phase II trial of palovarotene to treat FOP
Canada-based Clementia Pharmaceuticals has completed patient enrolment in its Phase II clinical trial of palovarotene, a retinoic acid receptor gamma agonist, to treat fibrodysplasia ossificans progressiva (FOP). (Source: Drug Development Technology)
Source: Drug Development Technology - March 1, 2016 Category: Pharmaceuticals Source Type: news

The teenager who's becoming a human statue: 17-year-old's muscles are turning to BONE due to bizarre incurable condition
Luciana Wulkan, 17, from Bolton, has Fibrodysplasia Ossificans Progressiva (FOP), one of the rarest and most disabling medical conditions, which turns muscle into solid bone. (Source: the Mail online | Health)
Source: the Mail online | Health - February 17, 2016 Category: Consumer Health News Source Type: news

Woman is desperate to conceive before genetic disease leaves her unable to move
Rachel Winnard, 31, from Rochdale, has Fibrodysplasia Ossificans Progressiva (FOP), one of the rarest and most disabling medical conditions, which turns muscle into solid bone. (Source: the Mail online | Health)
Source: the Mail online | Health - October 30, 2015 Category: Consumer Health News Source Type: news

Ashley Kurpiel has Fibrodysplasia Ossificans Progressiva that turns muscle into bone
Ashley Kurpiel, 32, Peachtree City, Georgia, has Fibrodysplasia Ossificans Progressiva (FOP), one of the rarest and most disabling medical conditions, which turns muscle into solid bone. (Source: the Mail online | Health)
Source: the Mail online | Health - October 22, 2015 Category: Consumer Health News Source Type: news

Clementia begins Phase II extension trial of palovarotene to treat FOP patients
Canada-based Clementia Pharmaceuticals has started a Phase II extension trial of palovarotene, an investigational retinoic acid receptor gamma agonist, to treat patients with fibrodysplasia ossificans progressiva (FOP), a rare and severely disabling … (Source: Drug Development Technology)
Source: Drug Development Technology - October 28, 2014 Category: Pharmaceuticals Source Type: news

The girl whose joints and muscles are turning to STONE: Horrific rare condition causes sufferers to become imprisoned in a second skeleton - which eventually suffocates them
Ni Min, 14, from China's Sichuan Province, suffers from the condition fibrodysplasia ossificans progressiva (FOP), also dubbed 'stone man' syndrome. (Source: the Mail online | Health)
Source: the Mail online | Health - September 25, 2014 Category: Consumer Health News Source Type: news

Clementia begins Phase II trial of palovarotene to treat fibrodysplasia ossificans progressiva
Canada-based Clementia Pharmaceuticals has started a double-blind, placebo-controlled Phase II clinical trial of palovarotene to treat fibrodysplasia ossificans progressiva (FOP), a rare, severely disabling genetic disease. (Source: Drug Development Technology)
Source: Drug Development Technology - July 15, 2014 Category: Pharmaceuticals Source Type: news

Stem cells used to model disease that causes abnormal bone growth (EurekAlert, 7 January 2014)
A US-Japan study published in the Orphanet Journal of Rare Diseases uses stem cells obtained from patients with the rare genetic condition fibrodysplasia ossificans progressiva to model abnormal bone growth, which the authors suggest could also model similar destructive processes occuring following major trauma. Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - January 9, 2014 Category: Endocrinology Source Type: news

[Erratum]A Correction to the Editors' Choice Summary Titled "Keeping Bone Where Bone Belongs" by Leslie K. Ferrarelli
Activating mutations in GNAS were mistakenly attributed as causing fibrodysplasia ossificans progressiva, instead of fibrous dysplasia. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 18, 2013 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

Girl, 17, battling rare disease that turns muscle into a second skeleton and will turn her into a living STATUE
Seanie Nammock, from West London, is suffering from fibrodysplasia ossificans progressiva (FOP), a condition that is turning her muscle and tendon into bone. (Source: the Mail online | Health)
Source: the Mail online | Health - July 29, 2013 Category: Consumer Health News Source Type: news

Fibrodysplasia Ossificans Progressiva : Woman rushes down the aisle before rare disease turns her into statue
Rachel Winnard, from Rochdale, asked her boyfriend to marry her so she could walk down the aisle before a rare condition turns all her muscle into bone. (Source: the Mail online | Health)
Source: the Mail online | Health - March 22, 2011 Category: Consumer Health News Source Type: news

Fibrodysplasia Ossificans Progressiva (FOP) - Facts and Information
Persons affected by FOP experience an inability to fully open their mouth, potentially causing eating and speaking difficulties. (Source: Disabled World)
Source: Disabled World - March 30, 2010 Category: Disability Tags: Types of Disability Source Type: news

How Can a Genetic Mutation Cause Muscle to Turn into Bone?
What would happen if some soft tissue cells in your body randomly got the message to transform into stiff bone cells? Patients born with a disease called fibrodysplasia ossificans progressiva (FOP) are locked into this fate, often becoming severely disabled before adulthood. [More] (Source: Scientific American Topic - Biotechnology)
Source: Scientific American Topic - Biotechnology - December 2, 2009 Category: Biotechnology Tags: Biology,Health & Medicine,Health Medicine,Everyday Science,Basic Science,Biotechnology,Biotechnology,Medical Technology Source Type: news

How Can a Genetic Mutation Cause Muscle to Turn into Bone?
What would happen if some soft tissue cells in your body randomly got the message to transform into stiff bone cells? Patients born with a disease called fibrodysplasia ossificans progressiva (FOP) are locked into this fate, often becoming severely disabled before adulthood. [More] (Source: Scientific American Topic - Medical Technology)
Source: Scientific American Topic - Medical Technology - December 2, 2009 Category: Consumer Health News Tags: Biology,Health & Medicine,Health Medicine,Everyday Science,Basic Science,Biotechnology,Biotechnology,Medical Technology Source Type: news

Study Provides Insight Into Bone-Overgrowth Disease
In patients with fibrodysplasia ossificans progressiva, a mutation in the ACVR1 receptor appears to promote cartilage formation by inducing bone morphogenetic protein signaling, according to research published in the November issue of the Journal of Clinical Investigation. (Source: Modern Medicine)
Source: Modern Medicine - November 20, 2009 Category: Journals (General) Source Type: news

First clear idea of how rare bone disease progresses
Scientists are taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 18, 2009 Category: Science Source Type: news

Study Provides First Clear Idea Of How Rare Bone Disease Progresses
An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton. (Source: Bones / Orthopaedics News From Medical News Today)
Source: Bones / Orthopaedics News From Medical News Today - November 13, 2009 Category: Orthopaedics Tags: Bones / Orthopaedics Source Type: news

Study Provides First Clear Idea Of How Rare Bone Disease Progresses
An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 13, 2009 Category: Consumer Health News Tags: Bones / Orthopaedics Source Type: news

Penn study provides first clear idea of how rare bone disease progresses
(University of Pennsylvania School of Medicine) An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 12, 2009 Category: Global & Universal Source Type: news

Mutant Gene Causes Muscles, Ligaments And Tendons To Turn Into Bones
According to recent research carried out at the University of Pennsylvania, USA, a mutant gene causes Fibrodysplasia Ossificans Progressiva (FOP), a rare incurable disorder which gradually turns muscles, ligaments and tendons into bone. A patient with FOP eventually becomes enveloped in a second skeleton and cannot move. The disorder usually begins in childhood. About one in two million people suffer from FOP. [click link for full article] (Source: Bones / Orthopaedics News From Medical News Today)
Source: Bones / Orthopaedics News From Medical News Today - April 24, 2006 Category: Orthopaedics Source Type: news