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This page shows you the latest research publications in this category.

Obstructive Sleep Apnea Impairs Postexercise Sympathovagal Balance in Patients with Metabolic Syndrome
Conclusions:The attenuation of heart rate recovery after maximal exercise is impaired to a greater degree where metabolic syndrome (MetS) is associated with moderate to severe obstructive sleep apnea (OSA) than by MetS with no or mild or no OSA. This is at least partly explained by sympathetic hyperactivity.Citation:Cepeda FX, Toschi-Dias E, Maki-Nunes C, Rondon MU, Alves MJ, Braga AM, Martinez DG, Drager LF, Lorenzi-Filho G, Negrao CE, Trombetta IC. Obstructive sleep apnea impairs postexercise sympathovagal balance in patients with metabolic syndrome. SLEEP 2015;38(7):1059–1066. (Source: Sleep)
Source: Sleep - June 30, 2015 Category: Sleep Medicine Source Type: research

Obesity and Cardiovascular Diseases in a High-Risk Population: Evidence-Based Approach to CHD Risk Reduction.
CONCLUSION: The high prevalence and increasing incidence of obesity and associated cardiovascular risk emphasizes the need to focus on obesity reduction in this high risk population. PMID: 26118150 [PubMed - in process] (Source: Ethnicity and Disease)
Source: Ethnicity and Disease - June 30, 2015 Category: Global & Universal Tags: Ethn Dis Source Type: research

Metabolic Syndrome: Can We Keep Check?
Conclusion Prevention is better than cure. The need of the hour is to target premenopausal women who are at risk of developing MetS in their postmenopausal age. It will delay and prevent them from future morbidities. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - June 30, 2015 Category: OBGYN Source Type: research

Hyperinsulinemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma
This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - June 30, 2015 Category: Gastroenterology Authors: Hamza Chettouh, Marie Lequoy, Laetitia Fartoux, Corinne Vigouroux, Christèle Desbois‐Mouthon Tags: Reviews Source Type: research

Sleep apnea syndrome in endocrine clinics
Abstract Obstructive sleep apnea syndrome (OSAS) is a chronic condition with a high prevalence (up to 7 % of the general population) characterized by frequent episodes of upper airway collapse while sleeping. Left untreated, OSAS can cause severe complications, including systemic hypertension, cardiovascular disease, stroke, and abnormal glucose metabolism. This review aims to summarize the close links between OSAS, endocrinology, and metabolism. In patients with metabolic syndrome, OSAS is an independent risk factor for the onset of type 2 diabetes and a worsening glycemic control. The accumulation of adipose ti...
Source: Journal of Endocrinological Investigation - June 30, 2015 Category: Endocrinology Source Type: research

Childhood obesity and cardiac remodeling: from cardiac structure to myocardial mechanics
Epidemic of obesity, especially morbid obesity, among children and adolescents, is a key factor associated with the dramatic increase in prevalence of type 2 diabetes mellitus, arterial hypertension, and metabolic syndrome in this population. Furthermore, childhood obesity represents a very important predictor of obesity in adulthood that is related to cardiovascular and cerebrovascular diseases. Overweight and obesity in children and adolescents are associated with impairment of cardiac structure and function. The majority of studies investigated the influence of obesity on left ventricular remodeling. However, the impact...
Source: Journal of Cardiovascular Medicine - June 29, 2015 Category: Cardiology Tags: Reviews: Cardiac function Source Type: research

Frequency of metabolic syndrome in patients with knuckle pads
Abstract Knuckle pads are hyperkeratotic, benign skin lesions that we commonly observe in obese patients. There is no study that investigates the association between metabolic syndrome (MetS) and knuckle pads. We aimed to investigate the frequency of MetS in patients with knuckle pads. Forty‐seven patients with knuckle pads and 46 age‐ and sex‐matched controls were enrolled. The presence of MetS was evaluated according to National Cholesterol Education Program–Adult Treatment Panel III criteria. In the patient group, waist circumference (P < 0.01), body mass index (BMI; P < 0.01), and systolic (P < 0...
Source: The Journal of Dermatology - June 29, 2015 Category: Dermatology Authors: Gulcan Saylam Kurtipek, Orkide Kutlu, Cevdet Duran, Huseyin Kurku, Arzu Ataseven, Fatma Tuncez Akyurek Tags: Original Article Source Type: research

SIRT3 regulates progression and development of diseases of aging
Publication date: Available online 29 June 2015 Source:Trends in Endocrinology &amp; Metabolism Author(s): Eoin McDonnell , Brett S. Peterson , Howard M. Bomze , Matthew D. Hirschey The mitochondrial sirtuin SIRT3 is a protein deacylase that influences almost every major aspect of mitochondrial biology, including nutrient oxidation, ATP generation, reactive oxygen species (ROS) detoxification, mitochondrial dynamics, and the mitochondrial unfolded protein response (UPR). Interestingly, mice lacking SIRT3 (SIRT3KO), either spontaneously or when crossed with mouse models of disease, develop several diseases of aging at...
Source: Trends in Endocrinology and Metabolism - June 29, 2015 Category: Endocrinology Source Type: research

Metabolic Syndrome Increases the Risk of Sudden Sensorineural Hearing Loss in Taiwan: A Case-Control Study
Conclusion These results suggest that metabolic syndrome is an independent risk factor for sudden sensorineural hearing loss in Taiwan. Vertigo and total hearing loss were indicators of a poor outcome in sudden sensorineural hearing loss. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - June 29, 2015 Category: ENT & OMF Authors: Chien, C.-Y., Tai, S.-Y., Wang, L.-F., Hsi, E., Chang, N.-C., Wu, M.-T., Ho, K.-Y. Tags: Otology and Neurotology Source Type: research

Epigenetic and developmental influences on metabolic syndrome
Smith CJ, Ryckman KK (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - June 28, 2015 Category: Endocrinology Source Type: research

Tree Nut consumption is associated with better adiposity measures and cardiovascular and metabolic syndrome health risk factors in U.S. Adults: NHANES 2005–2010
IntroductionPrevious research has shown inconsistencies in the association of tree nut consumption with risk factors for cardiovascular disease (CVD) and metabolic syndrome (MetS).ObjectiveTo determine the association of tree nut consumption with risk factors for CVD and for MetS in adults. Methods: NHANES 2005–2010 data were used to examine the associations of tree nut consumption with health risks in adults 19+ years (n = 14,386; 51 % males). Tree nuts were: almonds, Brazil nuts, cashews, filberts [hazelnuts], macadamias, pecans, pine nuts, pistachios, and walnuts. Group definitions were non-consumers 25/ (Sourc...
Source: Nutrition Journal - June 28, 2015 Category: Nutrition Authors: Carol O¿NeilVictor FulgoniTheresa Nicklas Source Type: research

Paediatrics, insulin resistance and the kidney
Abstract Systemic insulin resistance is becoming more prevalent in the young due to modern lifestyles predisposing to the metabolic syndrome and obesity. There is also evidence that there are critical insulin-resistant phases for the developing child, including puberty, and that renal disease per se causes systemic insulin resistance. This review considers the factors that render children insulin resistant, as well as the accumulating evidence that the kidney is an insulin-responsive organ and could be affected by insulin resistance. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - June 27, 2015 Category: Urology & Nephrology Source Type: research

Obesity, insulin resistance, and type 1 diabetes mellitus
Purpose of review: To summarize recent studies about obesity, insulin resistance, and type 1 diabetes mellitus (T1DM). Recent findings: Overweight and obesity continue to be prevalent among individuals with T1DM. Obesity rates appear to have reached a plateau among children with T1DM in some parts of the world. The risk for development of T1DM is increased by obesity and may occur at an earlier age among obese individuals with a predisposition. Obesity increases the risk for comorbidities among individuals with T1DM, especially metabolic syndrome, and microvascular and macrovascular diseases. Metformin, glucagon-like pepti...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - June 27, 2015 Category: Endocrinology Tags: DIABETES AND THE ENDOCRINE PANCREAS II: Edited by Peter A. Gottlieb Source Type: research

Re: Coustan “Follow-up of women with previous gestational diabetes” (comment on Noctor et al. ATLANTIC-DIP: prevalence of metabolic syndrome and insulin resistance in women with previous gestational diabetes mellitus by International Association of Diabetes in Pregnancy Study Groups criteria. Acta Diabetol 2015;52:153–160)
(Source: Acta Diabetologica)
Source: Acta Diabetologica - June 27, 2015 Category: Endocrinology Source Type: research

Metabolic abnormalities in young Egyptian women with polycystic ovary syndrome and their relation to ADIPOQ gene variants and body fat phenotype
Conclusion The prevalence of MS was significantly higher in PCOS women than controls, and central obesity and hypertension are risk factors for insulin resistance. Moreover, obesity plays a key role in the development of PCOS and ADIPOQ −11391G&gt;A gene variants showed association with MS. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - June 27, 2015 Category: Genetics & Stem Cells Source Type: research

Quantitative combination of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress
Publication date: Available online 26 June 2015 Source:Redox Biology Author(s): Mingjing Gao , Zhen Zhao , Pengyu Lv , YuFang Li , Juntao Gao , Michael Zhang , Baolu Zhao Insulin resistance and abdominal obesity are present in the majority of people with the metabolic syndrome. Antioxidant therapy might be a useful strategy for type 2 diabetes and other insulin-resistant states. The combination of vitamin C (Vc) and vitamin E has synthetic scavenging effect on free radicals and inhibition effect on lipid peroxidation. However, there are few studies about how to define the best combination of more than three anti-oxidants...
Source: Redox Biology - June 27, 2015 Category: Biology Source Type: research

Dietary Quality and Nutritional Biomarkers associated with Dietary Patterns of Socioeconomically Diverse Urban African American and White Population
The objective of this cross-sectional study was to determine the dietary and health-related quality of cluster patterns of African Americans and Whites, 30 to 64 years of age, examined in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. All ten clusters reflected a Western diet with low adherence to the Dietary Approaches to Stop Hypertension (DASH) eating pattern, ranging from 0.9 to 15.3%.Micronutrient adequacy scores ranged from 68.6 to 81.6 out of 100. Clinical and blood biomarkers provided evidence of the health risks for metabolic syndrome, inflammation, hypertension and prediabete...
Source: Procedia Food Science - June 27, 2015 Category: Food Science Source Type: research

Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder
ConclusionObesity and abdominal obesity, but not metabolic syndrome, were associated with less improvement after 6 months of lithium‐ or quetiapine‐based treatment. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - June 26, 2015 Category: Psychiatry Authors: S. L. McElroy, D. E. Kemp, E. S. Friedman, N. A. Reilly‐Harrington, L. G. Sylvia, J. R. Calabrese, D. J. Rabideau, T. A. Ketter, M. E. Thase, V. Singh, M. Tohen, C. L. Bowden, E. E. Bernstein, B. D. Brody, T. Deckersbach, J. H. Kocsis, G. Kinrys, W. V. Tags: Original Article Source Type: research

Dietary changes associated with improvement of metabolic syndrome components in postmenopausal women receiving two different nutrition interventions
Conclusions: Both strategies promote achievement of cardioprotective dietary goals for fruits/vegetables, sugars, soda and sweetened beverages, low-fat dairy, and high-energy refined grains, and improve some metabolic syndrome components. Elimination of high-fat dairy decreases the risk of impaired fasting glucose. Dietary strategies should be flexible and individualized based on metabolic profile. (Source: Menopause)
Source: Menopause - June 26, 2015 Category: OBGYN Tags: Original Articles Source Type: research

Let Them Eat Beef: Effects of Beef Consumption on Markers of Metabolic Syndrome
To determine the effects of a diet that provides 30% energy from protein with 1/2 as lean, red meat on risk factors of metabolic syndrome in humans. (Source: Journal of Nutrition Education and Behavior)
Source: Journal of Nutrition Education and Behavior - June 26, 2015 Category: Nutrition Authors: Kristin Olson, K. Kattelmann Tags: Poster Abstract Source Type: research

Designing a Nutrition Intervention to Profile Metabolomic, Microbiome and Vascular Health in Young Adults: FRUVEDomic Study
To design a multi-disciplinary nutrition education approach based on the 2010 Dietary Guidelines for Americans, using nutrition education, culinary toolkit and one-on-one counseling, to impact metabolomics, cardiovascular, and microbiome health in “at risk” young adults (18-28 years) for metabolic syndrome (metS). (Source: Journal of Nutrition Education and Behavior)
Source: Journal of Nutrition Education and Behavior - June 26, 2015 Category: Nutrition Authors: Melissa Olfert, O. Famodu, D. Kesner, J. White, M. Barr, C. Warner, M. Dehlin, M. Buerkle, M. Downs, C. Moore, P. Murray, J. McFadden, C. Cuff, S. Colby, J. Stabile Morrell, M. Olfert Tags: Poster Abstract Source Type: research

Leptin's role in psoriasis comprises a pro‐inflammatory response by the dermal fibroblast
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - June 26, 2015 Category: Dermatology Authors: P. Ommen, T. Stjernholm, T. Kragstrup, L. Raaby, C. Johansen, K. Stenderup, L. Iversen, C. Rosada Tags: Research Letter Source Type: research

Degludec: the new ultra-long insulin analogue
The development of extended-action insulin analogues was motivated by the unfavorable pharmacokinetic (PK) profile of the conventional long-acting insulin formulations, generally associated with marked inter and intra patient variability and site- and dose-dependent effect variation. The new ultra-long insulin analogue degludec (IDeg) has the same amino acid sequence as human insulin except for the removal of threonine in the position 30 of the B chain (Des-B30, “De”) and the attachment, via a glutamic acid linker (“glu”), of a 16-carbon fatty diacid (hexadecanoic diacid, “dec”) to lysine in the position 29 of ...
Source: Diabetology and Metabolic Syndrome - June 26, 2015 Category: Endocrinology Authors: Marcos TambasciaFreddy Eliaschewitz Source Type: research

FABP4 plasma concentrations are determined by acquired metabolic derangements rather than genetic determinants
Conclusions In clinical settings, the circulating FABP4 levels are determined by the acquired metabolic derangements and not genetic variation. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - June 26, 2015 Category: Nutrition Source Type: research

Fucoxanthin and lipid metabolism: a minireview
Conclusions The results of experimental studies suggest that consumption of fucoxanthin and its derivatives as nutritional supplements is a promising option for prevention and treatment of obesity and a wide variety of related pathologies, including metabolic syndrome, type 2 diabetes, and heart disease. Yet, clinical trials are warranted to assess a therapeutic value of fucoxanthin. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - June 26, 2015 Category: Nutrition Source Type: research

Effect of aerobic exercise training followed by a low-calorie diet on metabolic syndrome risk factors in men
Conclusion VO2peak increased more with HIIT than with MICT during the EXi despite HIIT having a lower exercise volume than MICT, but this advantage of HIIT promptly disappeared through detraining. An intervention strategy consisting of 8 weeks of either HIIT or MICT followed by a 4-week LCDi has a positive effect on metabolic risk factors. Clinical Trial Registration: UMIN11352. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - June 26, 2015 Category: Nutrition Source Type: research

Extra-media thickness and epicardial fat: Comparison of a novel carotid artery ultrasound index and a well-established cardiac magnetic resonance fat quantification method
Conclusions Our study showed the first findings on the relations between a novel ultrasound index EMT and EF assessed in a reference method of CMR. Carotid EMT may be a new surrogate marker, including both periarterial fat as a major component and arterial adventitia, which may provide additional data on cardiometabolic risk beyond that derived form a well-established EF alone. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - June 26, 2015 Category: Nutrition Source Type: research

Cardiovascular disease after liver transplantation: When, What, and Who Is at Risk
The evolution of metabolic and cardiovascular disease (CVD) complications after liver transplantation (LT) is poorly characterized. We aim to illustrate the prevalence of obesity and metabolic syndrome (MS), define the cumulative incidence of CVD, and characterize risk factors associated with these comorbidities after LT. A retrospective review of 455 consecutive LT recipients from 1999 to 2004 with an 8‐ to 12‐year follow‐up was performed. Obesity increased from 23.8% (4 months) to 40.8% (3 years) after LT. Increase in body mass index predicted MS at 1 year after LT (odds ratio, 1.1; P < 0.001, per point). CVD de...
Source: Liver Transplantation - June 26, 2015 Category: Transplant Surgery Authors: Lynn A. Fussner, Julie K. Heimbach, Chun Fan, Ross Dierkhising, Elizabeth Coss, Michael D. Leise, Kymberly D. Watt Tags: Original Article Source Type: research

The impact of metabolic syndrome and hypertension on medical costs of patients with acute myocardial infarction at hospital.
CONCLUSIONS: Metabolic syndrome has no impact on medical costs because of discordance in MS components. Hypertension will lead to lower PCI utilization rate, which results in less medical costs and bad hospital outcomes. PMID: 26114352 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 26, 2015 Category: Cardiology Authors: Fan GQ, Fu KL, Song M, Han L, Jin CW, Zhong M, Zhang Y, Zhang W, Wang ZH Tags: Clin Exp Hypertens Source Type: research

Preventing aggressive prostate cancer with proven cardiovascular disease preventive methods.
Abstract Cardiovascular disease (CVD) has been the number one cause of death in the U.S. for 114 of the last 115 years. Risk factors for prostate cancer have primarily mirrored risk proven risk factors for CVD, especially aggressive disease. Obesity, dyslipidemia, glucose intolerance, metabolic syndrome, unhealthy dietary habits or caloric excess, lack of physical activity, and inflammation are just some of these shared risk factors. The evidence also suggests proven CVD preventive measures are identical to prostate cancer preventive measures, especially in regard to aggressive disease. Thus, apart from lifestyle m...
Source: Asian Journal of Andrology - June 26, 2015 Category: Urology & Nephrology Authors: Moyad MA Tags: Asian J Androl Source Type: research

Metabolic syndrome is associated with left ventricular dilatation in primary hypertension
i & R Pontremoli (Source: Journal of Human Hypertension)
Source: Journal of Human Hypertension - June 25, 2015 Category: Cardiology Authors: E RattoF ViazziD VerzolaB BoninoA GonnellaE L ParodiG P BezanteG LeonciniR Pontremoli Source Type: research

Hepatic TLR4 Signaling in Obese NAFLD.
CONCLUSION: TLR4 expression is up-regulated in a large cohort of NASH patients, when compared to those with NAFL, and this occurs within the setting of increased LPS and fatty acids. PMID: 26113297 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - June 25, 2015 Category: Gastroenterology Authors: Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Role of canagliflozin metformin combination
Fleming JW, Fleming LW, Davis CS (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - June 24, 2015 Category: Endocrinology Source Type: research

Diabetinol® and glycemic control
Evans M, Judy WV, Wilson D, Rumberger JA, Guthrie N (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - June 24, 2015 Category: Endocrinology Source Type: research

Build muscle, improve health: benefits associated with resistance exercise
LEARNING OBJECTIVES: * To realize that age-related muscle loss is associated with bone loss, metabolic rate reduction, fat gain, diabetes, metabolic syndrome, heart disease, and various problems associated with physical degeneration/dysfunction. * To recognize the beneficial effects of resistance exercise for increasing muscle mass, bone density, metabolic rate, insulin sensitivity, high-density lipoprotein cholesterol, cognitive ability, and self-esteem, as well as for decreasing body fat, resting blood pressure, low-density lipoprotein cholesterol, low-back pain, arthritic discomfort, and depression. * To use program...
Source: ACSMs Health and Fitness Journal - June 24, 2015 Category: Sports Medicine Tags: Features Source Type: research

Feasibility and efficacy of diabetic retinopathy screening among youth with diabetes in a pediatric endocrinology clinic: a cross-sectional study
Conclusions: Use of a non-mydriatic fundus camera is feasible and efficacious for DR screening in youth with diabetes. DR screening at routine endocrinology visits may be beneficial in managing youth with diabetes and preventing irreversible vision loss, particularly for those in regions where diabetes rates are high. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - June 24, 2015 Category: Endocrinology Authors: Jeffrey TapleyGerald McGwinAmbika AshrafPaul MacLennanKoula CallahanKaren SearceyC. WitherspoonJinan SaaddineCynthia Owsley Source Type: research

Insulin mediated improvement in glycemic control in elderly with type 2 diabetes mellitus can improve depressive symptoms and does not seem to impair health-related quality of life
Conclusion: Insulin therapy in elderly people with type 2 diabetes can lead to an improvement of depressive symptoms and does not seem to affect negatively HRQoL of the participants. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - June 24, 2015 Category: Endocrinology Authors: R. OliveiraM. TostesV. QueirozM. RodackiL. Zajdenverg Source Type: research

Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it necessary to revise the risk assessment in vulnerable population?
Abstract In the last decades, many reports have focused the attention on deleterious effects of novel environmental chemical compounds, including bisphenol A (BPA), on human health. BPA, a common and widely chemical contaminant acting as endocrine disruptor, accumulates in adipose tissue and may affect adipocyte metabolic and inflammatory functions. BPA, at low chronic doses, is now considered as an obesogen compound, and might contribute to the rise of metabolic syndrome, visceral adiposity and diabetes epidemics. The BPA worldwide presence in the environment is responsible for chronic exposure during vulnerable ...
Source: Journal of Endocrinological Investigation - June 24, 2015 Category: Endocrinology Source Type: research

Decreased plasma endogenous soluble RAGE, and enhanced adipokine secretion, oxidative stress and platelet/coagulative activation identify non-alcoholic fatty liver disease among patients with Familial Combined Hyperlipidemia and/or Metabolic syndrome.
CONCLUSIONS: Among FCHL or MS patients, noncarriers of the protective genotypic cluster, with lower esRAGE and higher degree of atherothrombotic abnormalities coincide with the diagnosis of NAFLD. This suggests an interplay between genotype, adipokine secretion, oxidative stress and platelet/coagulative activation, accelerating NAFLD occurrence as a proxy for cardiovascular disease. PMID: 26117210 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - June 24, 2015 Category: Drugs & Pharmacology Authors: Santilli F, Blardi P, Scapellato C, Bocchia M, Guazzi G, Terzuoli L, Tabucchi A, Silvietti A, Lucani B, Gioffrè WR, Scarpini F, Fazio F, Davì G, Puccetti L Tags: Vascul Pharmacol Source Type: research

Obesity, Metabolic Syndrome, and Dietary Therapeutical Approaches with a Special Focus on Nutraceuticals (Polyphenols): A Mini-Review.
Authors: Ríos-Hoyo A, Cortés MJ, Ríos-Ontiveros H, Meaney E, Ceballos G, Gutiérrez-Salmeán G Abstract More than half of all global deaths in 2010 were related to non-communicable diseases, including obesity, cancers, diabetes, and cardiovascular illnesses. It has been suggested that the alarming increase in the incidence of cardiovascular disease is the epidemiologic result of a nutrition transition characterized by dietary patterns featuring an increase in the intake of total fat, cholesterol, sugars, and other refined carbohydrates, concomitant with low consumption of polyunsaturated fatty acids and fiber. A...
Source: International Journal for Vitamin and Nutrition Research - June 23, 2015 Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research

Relationship of Advanced Glycation End Products With Cardiovascular Disease in Menopausal Women
Cardiovascular disease (CVD) represents the most significant cause of death in postmenopausal women. Advanced glycation end products (AGEs) are formed by nonenzymatic modification of proteins, lipids, and nucleic acids by glucose. This review focuses on the contribution of AGEs and their receptors to the development of CVD in menopause. Advanced glycation end products circulate and activate the proinflammatory endothelial cell surface receptor called RAGE, bind to the extracellular matrix of the cardiovascular system, or bind to the circulating anti-inflammatory soluble form of RAGE (sRAGE). Data emerging from human and an...
Source: Reproductive Sciences - June 23, 2015 Category: Reproduction Medicine Authors: Pertynska-Marczewska, M., Merhi, Z. Tags: Review Source Type: research

Schizoaffective disorder and metabolic syndrome: A meta-analytic comparison with schizophrenia and other non-affective psychoses
Publication date: July–August 2015 Source:Journal of Psychiatric Research, Volumes 66–67 Author(s): Francesco Bartoli , Cristina Crocamo , Manuela Caslini , Massimo Clerici , Giuseppe Carrà People with psychotic disorders, including schizophrenia (SCZ), schizoaffective disorder (SD), or other non-affective psychoses (ONAP), have a higher risk of metabolic syndrome (MetS) than general population. However, previous meta-analyses failed to explore if people with SD are more likely to suffer from MetS than SCZ and ONAP. We carried out a systematic review and meta-analysis comparing rates of MetS in SD with those in SCZ ...
Source: Journal of Psychiatric Research - June 23, 2015 Category: Psychiatry Source Type: research

Gut Peptides Are Novel Regulators of Intestinal Lipoprotein Secretion: Experimental and Pharmacological Manipulation of Lipoprotein Metabolism
Individuals with metabolic syndrome and frank type 2 diabetes are at increased risk of atherosclerotic cardiovascular disease, partially due to the presence of lipid and lipoprotein abnormalities. In these conditions, the liver and intestine overproduce lipoprotein particles, exacerbating the hyperlipidemia of fasting and postprandial states. Incretin-based, antidiabetes therapies (i.e., glucagon-like peptide [GLP]-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) have proven efficacy for the treatment of hyperglycemia. Evidence is accumulating that these agents also improve fasting and postprandial lipemia, the l...
Source: Diabetes - June 23, 2015 Category: Endocrinology Authors: Xiao, C.; Dash, S.; Morgantini, C.; Adeli, K.; Lewis, G. F. Tags: Perspectives in Diabetes Source Type: research

Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPAR{gamma}-Dependent Switch From Lipogenesis to Fat Oxidation
Short-chain fatty acids (SCFAs) are the main products of dietary fiber fermentation and are believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that dietary SCFAs induce a peroxisome proliferator–activated receptor- (PPAR)–dependent switch from lipid synthesis to utilization. Dietary SCFA supplementation prevented and reversed high-fat diet–induced metabolic abnormalities in mice by decreasing PPAR expression and activity. This increased the expression of mitochondrial uncoupling protein 2 and raised the AMP-to-ATP ratio, thereby stimulating oxidative metabolism in liver...
Source: Diabetes - June 23, 2015 Category: Endocrinology Authors: den Besten, G.; Bleeker, A.; Gerding, A.; van Eunen, K.; Havinga, R.; van Dijk, T. H.; Oosterveer, M. H.; Jonker, J. W.; Groen, A. K.; Reijngoud, D.-J.; Bakker, B. M. Tags: Metabolism Source Type: research

Society for maternal and fetal medicine workshop on pregnancy as a window to future health: Clinical utility of classifying women with metabolic syndrome
Women with preeclampsia, gestational diabetes, and obesity during pregnancy are at risk for medical complications later in life. Therefore, practitioners should identify those who can benefit from early diagnosis and interventions. Metabolic syndrome is a cluster of risk factors including hypertension, elevated triglycerides, low high-density lipoprotein cholesterol, glucose intolerance, and obesity, which also identifies those at risk for cardiovascular disease. Taking the time to classify women with the metabolic syndrome does not necessarily offer risk stratification superior to that offered by identifying the individua...
Source: Seminars in Perinatology - June 23, 2015 Category: Perinatology & Neonatology Authors: Michael P. Carson Source Type: research

Associations of low muscle mass and the metabolic syndrome in Caucasian and Asian middle-aged and older adults
Conclusion Low aLM/BMI is associated with significantly increased likelihood of MetS in Australian adults, but not Koreans, suggesting potential differences in effects of low muscle mass relative to body mass on cardiometabolic health in Caucasian and Asian middle-aged and older adults. Low muscle mass relative to height is associated with reduced likelihood of MetS in both populations. (Source: The Journal of Nutrition, Health and Aging)
Source: The Journal of Nutrition, Health and Aging - June 23, 2015 Category: Nutrition Source Type: research

Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract improves obesity and survival of C57BL/6 mice fed a high-fat diet.
Abstract Melinjo (Gnetum gnemon L.) seed extracts (MSEs) are rich in resveratrol dimers (gnemonoside A, C, D, gnetin C), trans-Resveratrol, and other resveratrol derivatives. trans-Resveratrol is a widely studied caloric restriction mimetic. In mice fed a high-fat diet (HFD), trans-Resveratrol protects against obesity, type 2 diabetes, and premature death. Here, treatment of HFD-fed mice with 2.0% MSE significantly reduced body weight gain (p < 0.001), blood insulin (p < 0.01), and HOMA-IR (p < 0.05) after 8 weeks compared with untreated HFD-fed mice. Additionally, 0.2% MSE treatment of HFD-fed mice...
Source: Bioscience, Biotechnology, and Biochemistry - June 23, 2015 Category: Biochemistry Authors: Ikuta T, Saito S, Tani H, Tatefuji T, Hashimoto K Tags: Biosci Biotechnol Biochem Source Type: research

Physical activity, and not fat mass is a primary predictor of circadian parameters in young men.
Abstract Circadian rhythms are ≈24 h oscillations in physiology and behavior, and disruptions have been shown to have negative effects on health. Wrist skin temperature has been used by several groups as a valid method of assessing circadian rhythms in humans. We tested the hypothesis that circadian temperature amplitude (TempAmp) and stability (TempStab) would significantly differ among groups of healthy young men of varying adiposities, and that we could identify physiological and behavioral measures that were significantly associated with these temperature parameters. Wrist skin temperatures taken at 10 mi...
Source: Chronobiology International - June 23, 2015 Category: Biology Authors: Tranel HR, Schroder EA, England J, Black WS, Bush H, Hughes ME, Esser KA, Clasey JL Tags: Chronobiol Int Source Type: research

Natriuretic Peptides and Cardiometabolic Health.
Abstract Natriuretic peptides are cardiac-derived hormones with a range of protective functions, including natriuresis, diuresis, vasodilation, lusitropy, lipolysis, weight loss, and improved insulin sensitivity. Their actions are mediated through membrane-bound guanylyl cyclases that lead to production of the intracellular second-messenger cyclic guanosine monophosphate. A growing body of evidence demonstrates that genetic and acquired deficiencies of the natriuretic peptide system can promote hypertension, cardiac hypertrophy, obesity, diabetes mellitus, the metabolic syndrome, and heart failure. Clinically, natr...
Source: Circulation Journal - June 23, 2015 Category: Cardiology Authors: Gupta DK, Wang TJ Tags: Circ J Source Type: research

Weight loss after bariatric surgery
McGrice M, Don Paul K (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - June 22, 2015 Category: Endocrinology Source Type: research