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Metabolic Syndrome

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The Natural History of Subjects with Isolated Metabolic Syndrome- A Population Based Study
Metabolic syndrome (MS) as defined by the presence ≥3 ATP-NCEP-III criteria is associated with increased risk of cardiovascular disease and mortality. Isolated MS is defined as metabolic syndrome subjects that do not meet the diagnosis of hypertension and diabetes and are not on therapy for either, despite having elevated blood pressure and hyperglycemia. The natural history of isolated MS remains undefined. Objectives: To determine the natural history of isolated MS. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2014 Category: Cardiology Authors: Pratik A. Patel, Christopher Scott, Richard Rodeheffer, Horng Chen Tags: Outcomes II Source Type: research

The Soluble Guanylate Cyclase Genetic Variant rs13139571 Is Associated with an “Unfavorable” Metabolic Phenotype in an US General Community
Metabolic syndrome and dyslipidemia are important risk factors for heart failure. Nitric oxide (NO) induces vasodilation and also exerts a metabolic action by stimulating lipogenesis. In rodents, lipid accumulation and lipogenic enzymes are induced by NO and insulin-stimulated glucose uptake is dependent on intact NO synthesis in white adipose tissue. Mice that are knock-out for the inducible NO synthase gene are also protected from high-fat diet induced insulin resistance and NO inhibition in rodents on a high fat diet reduces hepatic lipid accumulation. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2014 Category: Cardiology Authors: Valentina Cannone, Christopher G. Scott, Kent R. Bailey, Timothy M. Olson, Jeanne L. Theis, Margaret M. Redfield, Richard J. Rodeheffer, John C. Burnett Tags: Epidemiology, Prevention I Source Type: research

Dietary Supplementation of Chinese Ginseng Prevents Obesity and Metabolic Syndrome in High-Fat Diet-Fed Mice
Journal of Medicinal Food , Vol. 0, No. 0. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - July 31, 2014 Category: Nutrition Tags: article Source Type: research

Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents
ng & Y Qiu (Source: European Journal of Clinical Nutrition)
Source: European Journal of Clinical Nutrition - July 30, 2014 Category: Nutrition Authors: P LiR JiangL LiC LiuF YangY Qiu Source Type: research

St. Jude: Unhealthy lifestyle elevates risks for childhood cancer survivors
New findings from St. Jude Children's Research Hospital show that childhood cancer survivors who maintain unhealthy habits into adulthood face extreme health risks. The study shows that adult survivors of childhood cancer who don’t exercise or eat right more than double their chances of developing metabolic syndrome, a disorder that increase the risk of heart disease, diabetes and other serious health problems. St. Jude researchers found the link by studying 1,598 childhood cancer survivors ranging… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - July 29, 2014 Category: American Health Authors: Rob Robertson Source Type: research

Metabolic Syndrome: Prevalence and Association with Electrocardiographic Abnormalities in Nigerian Hypertensive Patients
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - July 29, 2014 Category: Endocrinology Tags: article Source Type: research

Metabolic syndrome and renal cell carcinoma
Conclusions: In summary, there is a large body of evidence regarding the link between MS and RCC, within which each component of MS is considered to have a close causal association with RCC. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - July 29, 2014 Category: Cancer & Oncology Authors: Gui-Ming ZhangYao ZhuDing-Wei Ye Source Type: research

The association of metabolic syndrome and its factors with gallstone disease
Conclusions: The present study suggests that metabolic syndrome is related to gallstone disease. Waist circumference and high-density lipoprotein cholesterol are all associated with GSD. Men and women may possibly have different priorities and strategies to reduce the burden of GSD. (Source: BMC Family Practice)
Source: BMC Family Practice - July 29, 2014 Category: Primary Care Authors: I-Ching LinYu-Wen YangMei-Feng WuYi-Hui YehJenn-Chang LiouYing-Li LinChih-Hsiang Chiang Source Type: research

The intelligence paradox; will ET get the metabolic syndrome? Lessons from and for Earth
Mankind is facing an unprecedented health challenge in the current pandemic of obesity and diabetes. We propose that this is the inevitable (and predictable) consequence of the evolution of intelligence, which itself could be an expression of life being an information system driven by entropy. Because of its ability to make life more adaptable and robust, intelligence evolved as an efficient adaptive response to the stresses arising from an ever-changing environment. These adaptive responses are encapsulated by the epiphenomena of "hormesis", a phenomenon we believe to be central to the evolution of intelligence and essent...
Source: Nutrition and Metabolism - July 29, 2014 Category: Nutrition Authors: Alistair NunnGeoffrey GuyJimmy Bell Source Type: research

Fatty liver largely explains associations of subclinical hypothyroidism with insulin resistance, metabolic syndrome, and subclinical coronary atherosclerosis.
CONCLUSION: SCH with FL is associated with increased odds of MS, insulin resistance, and CAC, independent of potential confounders. PMID: 25053728 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - July 28, 2014 Category: Endocrinology Authors: Posadas-Romero C, Jorge-Galarza E, Posadas-Sánchez R, Acuña-Valerio J, Juárez-Rojas JG, Kimura-Hayama E, Medina-Urrutia A, Cardoso-Saldaña GC Tags: Eur J Endocrinol Source Type: research

Prevalence, components and associated demographic and lifestyle factors of the metabolic syndrome in type 2 diabetes mellitus.
CONCLUSION: A comparatively low prevalence of the MetS was found. More females than males had the MetS. Uncontrolled diabetes and abdominal obesity were prevalent. The factors identified by our univariate logistic regression model were not significant predictors of the MetS in our multivariate model. PMID: 25054102 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - July 28, 2014 Category: Endocrinology Authors: Mogre V, Salifu ZS, Abedandi R Tags: J Diabetes Metab Disord Source Type: research

Prevalence of metabolic syndrome among hispanics/latinos of diverse background: the Hispanic community health study/study of latinos.
CONCLUSIONS: The burden of cardiometabolic abnormalities is high in Hispanic/Latinos but varies by age, sex, and Hispanic/Latino background. Hispanics/Latinos are thus at increased, but modifiable, predicted lifetime risk of diabetes and its cardiovascular sequelae. PMID: 25061141 [PubMed - in process] (Source: Diabetes Care)
Source: Diabetes Care - July 28, 2014 Category: Endocrinology Authors: Heiss G, Snyder ML, Teng Y, Schneiderman N, Llabre MM, Cowie C, Carnethon M, Kaplan R, Giachello A, Gallo L, Loehr L, Avilés-Santa L Tags: Diabetes Care Source Type: research

Lifestyle and metabolic syndrome in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study
CONCLUSIONSAdherence to a heart‐healthy lifestyle is associated with a lower risk of MetSyn among CCS. There is a need to determine whether lifestyle interventions prevent or remediate MetSyn in CCS. Cancer 2014. © 2014 American Cancer Society. (Source: Cancer)
Source: Cancer - July 28, 2014 Category: Cancer & Oncology Authors: Webb A. Smith, Chenghong Li, Kerri A. Nottage, Daniel A. Mulrooney, Gregory T. Armstrong, Jennifer Q. Lanctot, Wassim Chemaitilly, Joseph H. Laver, Deo Kumar Srivastava, Leslie L. Robison, Melissa M. Hudson, Kirsten K. Ness Tags: Original Article Source Type: research

ABCC6- a new player in cellular cholesterol and lipoprotein metabolism?
Conclusion: Increased cholesterol biosynthesis, elevated PCSK9 levels and reduced APOE mRNA expression newly found in PXE fibroblasts could enforce atherogenesis and cardiovascular risk in PXE patients. Moreover, the increase in ABCC6 expression accompanied by the induction of cholesterol biosynthesis supposes a functional role for ABCC6 in human lipoprotein and cholesterol homeostasis. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - July 27, 2014 Category: Lipidology Authors: Patricia KuzajJoachim KuhnMareike Dabisch-RutheIsabel FaustChristian GöttingCornelius KnabbeDoris Hendig Source Type: research

Adipose tissue and vascular inflammation in coronary artery disease.
Abstract Obesity has become an important public health issue in Western and developing countries, with well known metabolic and cardiovascular complications. In the last decades, evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences. As a consequence of the expansion of fat depots, in obese subjects, adipose tissue cells develope a phenotypic modification, which turns into a change of the secretory output. Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling,...
Source: World Journal of Cardiology - July 26, 2014 Category: Cardiology Authors: Golia E, Limongelli G, Natale F, Fimiani F, Maddaloni V, Russo PE, Riegler L, Bianchi R, Crisci M, Palma GD, Golino P, Russo MG, Calabrò R, Calabrò P Tags: World J Cardiol Source Type: research

The relationship between cognitive performance and insulin resistance in non‐diabetic patients with mild cognitive impairment
ConclusionThis study found a domain‐specific impact of HOMA‐IR scores on cognitive performances in non‐diabetic patients with MCI. This association was profound only in APOE ε4carriers. Copyright © 2014 John Wiley & Sons, Ltd. (Source: International Journal of Geriatric Psychiatry)
Source: International Journal of Geriatric Psychiatry - July 25, 2014 Category: Geriatrics Authors: Tae‐Eun Kim, Dong Hyun Lee, Yoon‐Jeong Kim, Ji Oh Mok, Chul‐ Hee Kim, Jeong‐Ho Park, Tae‐Kyeong Lee, Kwangsun Yoo, Yong Jeong, Yunhwan Lee, Sun Ah Park Tags: Research Article Source Type: research

Association of erythrocyte deformability with red blood cell distribution width in metabolic diseases and thalassemia trait.
Abstract Increased red blood distribution width (RDW) in anemia is related to disturbances in the cellular surface/volume ratio, usually accompanied by morphological alterations, while it has been shown in inflammatory diseases that the activity of pro-inflammatory cytokines disturbing erythropoiesis increases RDW. Recently it has been reported that higher RDW is related with decreased erythrocyte deformability, and that it could be related with the association of RDW and increased risk of cardiovascular diseases. In order to analyze the influence of morphological alterations and proinflammatory status on the relat...
Source: Clinical Hemorheology and Microcirculation - July 25, 2014 Category: Hematology Authors: Vayá A, Alis R, Suescún M, Rivera L, Murado J, Romagnoli M, Solá E, Hernandez-Mijares A Tags: Clin Hemorheol Microcirc Source Type: research

Cardiovascular and Metabolic Risk Factors in Inherited Auto-inflammation.
Conclusions: FMF is associated with lower rates of most components of the metabolic syndrome compared to normal subjects, unlike other inflammatory conditions. PMID: 25062460 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 25, 2014 Category: Endocrinology Authors: Twig G, Livneh A, Vivante A, Arnon A, Derazne E, Leiba A, Shor DB, Meydan C, Ben-Zvi I, Tzur D, Furer A, Imazio M, Adler Y, Amital H Tags: J Clin Endocrinol Metab Source Type: research

Serum choline plasmalogens-those with oleic acid in sn-2-are biomarkers for coronary artery disease.
CONCLUSION: These results verify our previous findings that serum PlsCho, particularly those containing 18:1 in sn-2, may serve as reliable biomarkers for atherosclerosis. PMID: 25068205 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - July 25, 2014 Category: Chemistry Authors: Nishimukai M, Maeba R, Ikuta A, Asakawa N, Kamiya K, Yamada S, Yokota T, Sakakibara M, Tsutsui H, Sakurai T, Takahashi Y, Hui SP, Chiba H, Okazaki T, Hara H Tags: Clin Chim Acta Source Type: research

'Red Ruby': an interactive web-based intervention for lifestyle modification on metabolic syndrome: a study protocol for a randomized controlled trial
This study will therefore make an important contribution to this novel field of research and practice.Trial registration: IRCT201111198132N1 (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - July 24, 2014 Category: Consumer Health News Authors: Leila JahangiryDavoud ShojaeizadehMahdi NajafiKazem MohammadMahdieh Abbasalizad FarhangiAli Montazeri Source Type: research

High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis
Conclusions HIIT significantly increases CRF by almost double that of MICT in patients with lifestyle-induced chronic diseases. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - July 24, 2014 Category: Sports Medicine Authors: Weston, K. S., Wisloff, U., Coombes, J. S. Tags: Obesity (nutrition), Physiotherapy, Physiotherapy, Health education, Obesity (public health) Review Source Type: research

MINIREVIEW: The Importance of Nutrient Flux [Lipids]
Hepatic glucose and lipid metabolism are altered in metabolic disease (e.g. obesity, metabolic syndrome, and Type 2 diabetes). Insulin-dependent regulation of glucose metabolism is impaired. In contrast, lipogenesis, hypertriglyceridemia, and hepatic steatosis are increased. Because insulin promotes lipogenesis and liver fat accumulation, to explain the elevation in plasma and tissue lipids, investigators have suggested the presence of pathway-selective insulin resistance. In this model, insulin signaling to glucose metabolism is impaired, but insulin signaling to lipid metabolism is intact. We discuss the evidence for the...
Source: Journal of Biological Chemistry - July 24, 2014 Category: Chemistry Authors: Otero, Y. F., Stafford, J. M., McGuinness, O. P. Tags: Minireviews Source Type: research

Elevated odds of metabolic syndrome in psoriasis - A population-based study of age and gender differences.
CONCLUSIONS: This study suggests age and gender variations in the risk of metabolic syndrome among individuals with psoriasis. Given the high prevalence of psoriasis and the significantly elevated burden of metabolic syndrome in this patient group, there may be a benefit from targeted screening of metabolic syndrome among individuals with psoriasis regardless of age and disease severity. This article is protected by copyright. All rights reserved. PMID: 25059341 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 24, 2014 Category: Dermatology Authors: Danielsen K, Wilsgaard T, Olsen AO, Eggen AE, Olsen K, Cassano PA, Furberg AS Tags: Br J Dermatol Source Type: research

Genetic Insulin Resistance is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells.
Abstract Insulin resistance is central to diabetes and metabolic syndrome. To define the consequences of genetic insulin resistance distinct from those secondary to cellular differentiation or in vivo regulation, we generated induced pluripotent stem cells (iPSC) from individuals with insulin receptor mutations and age-appropriate controls, and studied insulin signaling and gene expression in comparison to fibroblasts from which they were derived. iPSC from patients with genetic insulin resistance exhibited altered insulin signaling, paralleling that seen in the original fibroblasts. Insulin-stimulated expression o...
Source: Diabetes - July 24, 2014 Category: Endocrinology Authors: Iovino S, Burkart AM, Kriauciunas K, Warren L, Hughes KJ, Molla M, Lee YK, Patti ME, Kahn CR Tags: Diabetes Source Type: research

Invited Commentary: Nighttime Light Exposure as a Risk Factor for Obesity Through Disruption of Circadian and Circannual Rhythms
In this issue of the American Journal of Epidemiology, McFadden et al. (Am J Epidemiol. 2014;180(3):245–250) report findings on the relationship between light exposure at night and obesity from a cross-sectional study of United Kingdom women. Their research extends findings from a previous study with elderly participants by including a larger sample size of over 100,000 women and a broader age range of 16 years or older. The findings are consistent with animal studies showing that prolonged light exposure leads to weight gain. Humans’ circadian, circannual, and metabolic regulatory systems evolved to be adaptiv...
Source: American Journal of Epidemiology - July 23, 2014 Category: Epidemiology Authors: Gangwisch, J. E. Tags: RESEARCH-ARTICLE Source Type: research

Aqueous extract of post-fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition
Conclusion: JWFT could mitigate the obesity-induced hepatic steatosis by regulating hepatic lipogenesis and lipolysis. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - July 23, 2014 Category: Complementary Medicine Authors: Jie ZhouLiang ZhangJingsong ZhangXiaochun Wan Source Type: research

Cardiovascular risk factors among bipolar disorder patients admitted to an inpatient unit of a tertiary care hospital in India.
CONCLUSIONS: Findings of the present study suggest the presence of cardiovascular risk factors and higher rate of metabolic syndrome in patients with bipolar disorder. Considering this fact, there is an urgent need for routine screening for cardiovascular risk factors in these patients. Mental health professionals should be aware of these risks; there is need to develop preventive strategies to reduce the cardiovascular risk in this population. PMID: 25042952 [PubMed - in process] (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - July 22, 2014 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Therapeutic perspectives of epigenetically active nutrients
Abstract Many nutrients are known for a wide range of activities in prevention and alleviation of various diseases. Recently, their potential role in epigenetics regulating human health has become evident, although specific mechanisms are still unclear. Thus, nutriepigenetics/nutriepigenomics has emerged as a new and promising field in current epigenetics research in the past few years. In particular, polyphenols, as part of the central dynamic interaction between the genome and the environment with specificity at physiological concentrations, are well known to affect mechanisms underlying human health. This review summari...
Source: British Journal of Pharmacology - July 22, 2014 Category: Drugs & Pharmacology Authors: M Remely, L Lovrecic, A L Garza, L Migliore, B Peterlin, F I Milagro, A J Martinez, A G Haslberger Tags: Review Article – Epigenetics and Therapy Themed Issue Source Type: research

Osteoprotegerin is not a determinant of metabolic syndrome in sub-Saharan Africans after age adjustment.
CONCLUSION: This study failed to demonstrate any relationship between OPG and MetS. Nevertheless, the positive association between blood glucose and OPG levels reveals that OPG might be involved in cardiovascular risk development in this sub-Saharan African population. PMID: 25063075 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - July 22, 2014 Category: Endocrinology Authors: Ayina Ayina CN, Boudou P, Fidaa I, Vounsia Balti E, Sobngwi E, Ngoa LS, Gautier JF Tags: Ann Endocrinol (Paris) Source Type: research

Deleted in Breast Cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype.
Abstract Obesity is often regarded as the primary cause of metabolic syndrome. However, many lines of evidence suggest that obesity may develop as a protective mechanism against tissue damage during caloric surplus, and it is only when the maximum fat accumulation capacity is reached and fatty acid spillover occurs into to peripheral tissues, that metabolic diseases develop. In this regard it is imperative to identify the molecular mechanisms that modulate adipocyte fat accumulation and fatty acid spillover. Here we identify the protein Deleted in Breast Cancer 1 (DBC1) as a key regulator of fat storage capacity of...
Source: Diabetes - July 22, 2014 Category: Endocrinology Authors: Escande C, Nin V, Pirtskhalava T, Chini CC, Tchkonia T, Kirkland JL, Chini EN Tags: Diabetes Source Type: research

Do n-3 Polyunsaturated Fatty Acids Increase or Decrease Lipid Peroxidation in Humans?
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - July 21, 2014 Category: Endocrinology Tags: article Source Type: research

Race and Gender Disparities in Nutrient Intake Are Not Related to Metabolic Syndrome in 20- to 59-Year-Old US Adults
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - July 21, 2014 Category: Endocrinology Tags: article Source Type: research

Target organ damage and cardiovascular risk factors among subjects with previously undiagnosed hypertension
Conclusions Among subjects with previously undiagnosed hypertension, one in five patients had evidence of subclinical target organ damage, and three in four patients may be regarded as having high cardiovascular risk. (Source: European Journal of Preventive Cardiology)
Source: European Journal of Preventive Cardiology - July 21, 2014 Category: Cardiology Authors: Korhonen, P. E., Kautiainen, H., Jarvenpaa, S., Kantola, I. Tags: Original scientific papers Source Type: research

Liver proteomic response to hypertriglyceridemia in human-apolipoprotein C-III transgenic mice at cellular and mitochondrial compartment levels
Conclusions: These results indicate that the metabolic response to HTG in human apolipoprotein C-III overexpressing mice may support a high TG production rate and that the cytosol of hepatocytes is subjected to an important oxidative stress, probably as a result of FFA over-accumulation, iron overload and enhanced activity of some ROS-producing catabolic enzymes. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - July 21, 2014 Category: Lipidology Authors: Grégory EhxStéphanie GérinGrégory MathyFabrice FranckHelena OliveiraAnibal VercesiFrancis Sluse Source Type: research

Peripheral blood mononuclear cells as in vivo model for dietary intervention induced systemic oxidative stress.
Abstract Our aim was to assess the use of peripheral blood mononuclear cells (PBMC) as an in vivo cellular model to evaluate diet-induced changes in the oxidative stress status by analysing the gene expression pattern of NADPH-oxidase subunits and antioxidant genes. A randomized, controlled trial assigned metabolic syndrome (MetS) patients to 4 diets for 12 weeks each: (i) high-saturated fatty acid (HSFA), (ii) high-monounsaturated fatty acid (HMUFA), and (iii) (iv) two low-fat, high-complex carbohydrate diets supplemented with n-3 polyunsaturated fatty acids (LFHCC n-3) or placebo (LFHCC). A fat challenge reflecti...
Source: Food and Chemical Toxicology - July 21, 2014 Category: Food Science Authors: Camargo A, Peña-Orihuela P, Rangel-Zúñiga OA, Pérez-Martínez P, Delgado-Lista J, Cruz-Teno C, Marín C, Tinahones F, Malagón MM, Roche HM, Pérez-Jiménez F, López-Miranda J Tags: Food Chem Toxicol Source Type: research

Effect of restorative yoga vs. stretching on diurnal cortisol dynamics and psychosocial outcomes in individuals with the metabolic syndrome: The PRYSMS randomized controlled trial
Activation of the stress response by cortisol is essential for life. However, chronic stimulation of the autonomic nervous system (ANS) by chronic life stresses can lead to metabolic changes including abdominal obesity, high triglycerides, low HDL-cholesterol, hypertension, and hyperglycemia. The clustering of these factors is called the metabolic syndrome, and may be at least partially due to dysregulation of the neuroendocrine system (Rosmond, 2005; Walker, 2006; Anagnostis et al., 2009). To date, studies investigating the relationship between cortisol and the metabolic syndrome have yielded mixed results, with some stud...
Source: Psychoneuroendocrinology - July 21, 2014 Category: Psychiatry Authors: Sarah M. Corey, Elissa Epel, Michael Schembri, Sarah B. Pawlowsky, Roger J. Cole, Maria Rosario G. Araneta, Elizabeth Barrett-Connor, Alka M. Kanaya Source Type: research

Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease and type 2 diabetes.
Semple RK, Frayling TM Abstract The mechanisms that predispose to hypertension, coronary artery disease (CAD) and type 2 diabetes (T2D) in individuals of normal weight are poorly understood. In contrast, in monogenic primary lipodystrophy - a reduction in subcutaneous adipose tissue - it is clear that it is adipose dysfunction that causes severe insulin resistance (IR), hypertension, coronary artery disease and type 2 diabetes. We aimed to test the hypothesis that common alleles associated with insulin resistance also influence the wider clinical and biochemical profile of monogenic insulin resistance. We selected...
Source: Diabetes - July 21, 2014 Category: Endocrinology Authors: Yaghootkar H, Scott RA, White CC, Zhang W, Speliotes E, Munroe PB, Ehret GB, Bis JC, Fox CS, Walker M, Borecki IB, Knowles JW, Yerges-Armstrong L, Ohlsson C, Perry JR, Chambers JC, Kooner JS, Franceschini N, Langenberg C, Hivert MF, Dastani Z, Richards JB Tags: Diabetes Source Type: research

Positive Attributes Protect Adolescents From Risk for the Metabolic Syndrome
Risk for cardiovascular disease develops as early as adolescence. The primary objective of the present study was to identify whether low levels of positive and high levels of negative emotions and attitudes are associated with the combination of cardiovascular risk factors known as the metabolic syndrome. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - July 21, 2014 Category: Child Development Authors: Aimee J. Midei, Karen A. Matthews Source Type: research

Associations of prenatal growth with metabolic syndrome, insulin resistance, and nutritional status in chilean children.
Conclusions. Prenatal growth influences MS, IR, and nutritional status. Prenatal growth was more important than present body composition in determining these outcomes. PMID: 25025054 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 19, 2014 Category: Research Authors: Mardones F, Arnaiz P, Pacheco P, Dominguez A, Villarroel L, Eriksson JG, Barja S, Farías M, Castillo O Tags: Biomed Res Int Source Type: research

Is abnormal non-high-density lipoprotein cholesterol a gender-specific predictor for metabolic syndrome in patients with schizophrenia taking second-generation antipsychotics?
This study supports a greater prevalence of MetS in patients with schizophrenia taking SGAs than in the general population. Abnormal BMI and non-HDL-C were significantly associated with developing MetS, and an abnormal non-HDL-C was a specific risk factor for men. Future development of specific interventions and regular monitoring for MetS is imperative for early identification and prevention. PMID: 25034455 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - July 19, 2014 Category: Endocrinology Authors: Lin EC, Shao WC, Yang HJ, Yen M, Lee SY, Wu PC, Lu RB Tags: Metab Brain Dis Source Type: research

Small Dense LDL Cholesterol Measured by Homogeneous Assay in Japanese Healthy Controls, Metabolic Syndrome and Diabetes Patients with or without a Fatty Liver.
CONCLUSIONS: Significantly elevated sdLDL-C levels were found in pre-MetS, MetS and pre-T2DM, T2DM patients compared to the healthy controls. Fatty liver significantly enhanced serum sdLDL-C levels and the multiple regression analyses ascertained that fatty liver was an independent determinant for sdLDL-C. PMID: 25050800 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - July 19, 2014 Category: Chemistry Authors: Kikkawa K, Nakajima K, Shimomura Y, Tokita Y, Machida T, Sumino H, Murakami M Tags: Clin Chim Acta Source Type: research

Serum HDL-C level of Iranian adults: results from sixth national Surveillance of Risk Factors of Non-Communicable Disease.
CONCLUSIONS: High level of HDL-C among Iranian adults was shown in this study which can be a major reason of increasing incidence of heart diseases in Iran. Hence, formulating policy regulations and interventions in Iranian lifestyle to reduce HDL-C levels should be among top priorities for health politicians. PMID: 25028645 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - July 18, 2014 Category: Endocrinology Authors: Hosseini M, Navidi I, Yousefifard M, Heshmat R, Koohpayehzadeh J, Asgari F, Etemad K, Rafei A, Gouya MM Tags: J Diabetes Metab Disord Source Type: research

AMPK activation: a therapeutic target for type 2 diabetes?
Abstract Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have T2D, and the International Diabetes Federation projects that this number will increase to nearly 600 million by 2035. There is a great need for more effective treatments for maintaining glucose homeostasis and improving insulin sensitivity. AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase whose activation elicits insulin-sensitizing effects, making it an ideal therapeutic target for T2D. A...
Source: Diabetes Metab - July 18, 2014 Category: Endocrinology Authors: Coughlan KA, Valentine RJ, Ruderman NB, Saha AK Tags: Diabetes Metab Syndr Obes Source Type: research

Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity.
This study aimed to delineate the associations of the MetS with plasma PON1 activity, PON1 Q192R genotypes, smoking, and mood disorders (major depression and bipolar disorder), while adjusting for HDL cholesterol, body mass index, age, gender, and sociodemographic data. We measured plasma PON1 activity and serum HDL cholesterol and determined PON1 Q192R genotypes through functional analysis in 335 subjects, consisting of 97 with and 238 without MetS. The severity of nicotine dependence was measured using the Fagerström Nicotine Dependence Scale. Results PON1 Q192R functional genotypes and PON1 Q192R genotypes by smoking i...
Source: Redox Report : communications in free radical research - July 18, 2014 Category: Biochemistry Authors: Bortolasci CC, Vargas HO, Souza-Nogueira A, Gastaldello Moreira E, Vargas Nunes SO, Berk M, Dodd S, Barbosa DS, Maes M Tags: Redox Rep Source Type: research

Exercise-mediated vasodilation in human obesity and metabolic syndrome: Effect of acute ascorbic acid infusion.
In conclusion, AA infusion during rhythmic forearm exercise does not alter the time course or magnitude of exercise-mediated vasodilation in groups of young lean, obese, or MetSyn adults. However, systemic inflammation may limit the MRT to exercise, which can be improved with AA. PMID: 25038148 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 18, 2014 Category: Physiology Authors: Limberg JK, Kellawan JM, Harrell JW, Johansson R, Eldridge MW, Proctor LT, Sebranek JJ, Schrage WG Tags: Am J Physiol Heart Circ Physiol Source Type: research

Polycystic ovaries is a disproportionate signal in pharmacovigilance data mining of second generation antipsychotics
Second generation antipsychotics are now generally accepted as an iatrogenic cause or aggravator of metabolic illnesses (Meyer and Nasrallah, 2009). Polycystic ovarian syndrome (PCOS) has been referred to as women's version of the metabolic syndrome. It is associated with increased prevalence of insulin resistance and type 2 diabetes even when controlled for body mass index (Moran et al., 2010). Decreased peripheral insulin sensitivity and consequent hyperinsulinemia are believed to play key roles in the pathogenesis of PCOS. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 18, 2014 Category: Psychiatry Authors: Sun Kyoung Yum, Tak Kim, Michael Y. Hwang Source Type: research

Circadian clock desynchronisation and metabolic syndrome
There is emerging evidence in the literature to suggest that disruption of the normal circadian rhythm (sleep–wake cycle signalling) is a potential risk factor to explain the increased incidence of metabolic syndrome. Over the last century, obesity, diabetes and other components of metabolic syndrome have been on the rise. On the other hand, the amount of sleep has decreased from an average of 6–8 h per night. Furthermore, the quality of sleep has declined with more individuals voluntarily decreasing their amount of sleep to work or enjoy leisure activities. Over the last decade, researchers have examined ...
Source: Postgraduate Medical Journal - July 17, 2014 Category: Journals (General) Authors: Sheikh-Ali, M., Maharaj, J. Tags: Reviews Source Type: research

Predominant role of GIP in the development of a metabolic syndrome-like phenotype in female Wistar rats submitted to forced catch-up growth.
In conclusion, the exacerbated production and secretion of GIP after the catch-up growth seems to represent the stimulus for insulin hypersecretion and insulin resistance, ultimately resulting in derangement of glucose homeostasis. Overall, these data evidence the role of GIP as a critical link between catch-up growth and the development of metabolic disturbances. PMID: 25032669 [PubMed - as supplied by publisher] (Source: Endocrinology)
Source: Endocrinology - July 17, 2014 Category: Endocrinology Authors: De Toro-Martín J, Fernández-Millán E, Lizárraga-Mollinedo E, López-Oliva E, Serradas P, Escrivá F, Alvarez C Tags: Endocrinology Source Type: research

Circulating pathogen associated molecular pattern – Binding proteins and High Mobility Group Box protein 1 in nascent Metabolic Syndrome: Implications for cellular Toll-like receptor activity
(Source: Atherosclerosis)
Source: Atherosclerosis - July 17, 2014 Category: Cardiology Authors: I. Jialal, U. Rajamani, B. Adams-Huet, H. Kaur Source Type: research

Circulating irisin and GIP are associated with the development of polycystic ovary syndrome.
Conclusion: Although there is as yet no evidence for a causal link between irisin and/or GIP and PCOS, it is conceivable that irisin and GIP might contribute to the the develpment of PCOS and may also represent novel PCOS biomarkers. PMID: 25029417 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 16, 2014 Category: Endocrinology Authors: Chang CL, Huang SY, Soong YK, Cheng PJ, Wang CJ, Liang IT Tags: J Clin Endocrinol Metab Source Type: research