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Metabolic Syndrome

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Cardiovascular risk factors among bipolar disorder patients admitted to an inpatient unit of a tertiary care hospital in India.
CONCLUSIONS: Findings of the present study suggest the presence of cardiovascular risk factors and higher rate of metabolic syndrome in patients with bipolar disorder. Considering this fact, there is an urgent need for routine screening for cardiovascular risk factors in these patients. Mental health professionals should be aware of these risks; there is need to develop preventive strategies to reduce the cardiovascular risk in this population. PMID: 25042952 [PubMed - in process] (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - July 22, 2014 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Therapeutic perspectives of epigenetically active nutrients
Abstract Many nutrients are known for a wide range of activities in prevention and alleviation of various diseases. Recently, their potential role in epigenetics regulating human health has become evident, although specific mechanisms are still unclear. Thus, nutriepigenetics/nutriepigenomics has emerged as a new and promising field in current epigenetics research in the past few years. In particular, polyphenols, as part of the central dynamic interaction between the genome and the environment with specificity at physiological concentrations, are well known to affect mechanisms underlying human health. This review summari...
Source: British Journal of Pharmacology - July 22, 2014 Category: Drugs & Pharmacology Authors: M Remely, L Lovrecic, A L Garza, L Migliore, B Peterlin, F I Milagro, A J Martinez, A G Haslberger Tags: Review Article – Epigenetics and Therapy Themed Issue Source Type: research

Do n-3 Polyunsaturated Fatty Acids Increase or Decrease Lipid Peroxidation in Humans?
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - July 21, 2014 Category: Endocrinology Tags: article Source Type: research

Race and Gender Disparities in Nutrient Intake Are Not Related to Metabolic Syndrome in 20- to 59-Year-Old US Adults
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - July 21, 2014 Category: Endocrinology Tags: article Source Type: research

Target organ damage and cardiovascular risk factors among subjects with previously undiagnosed hypertension
Conclusions Among subjects with previously undiagnosed hypertension, one in five patients had evidence of subclinical target organ damage, and three in four patients may be regarded as having high cardiovascular risk. (Source: European Journal of Preventive Cardiology)
Source: European Journal of Preventive Cardiology - July 21, 2014 Category: Cardiology Authors: Korhonen, P. E., Kautiainen, H., Jarvenpaa, S., Kantola, I. Tags: Original scientific papers Source Type: research

Liver proteomic response to hypertriglyceridemia in human-apolipoprotein C-III transgenic mice at cellular and mitochondrial compartment levels
Conclusions: These results indicate that the metabolic response to HTG in human apolipoprotein C-III overexpressing mice may support a high TG production rate and that the cytosol of hepatocytes is subjected to an important oxidative stress, probably as a result of FFA over-accumulation, iron overload and enhanced activity of some ROS-producing catabolic enzymes. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - July 21, 2014 Category: Lipidology Authors: Grégory EhxStéphanie GérinGrégory MathyFabrice FranckHelena OliveiraAnibal VercesiFrancis Sluse Source Type: research

Associations of prenatal growth with metabolic syndrome, insulin resistance, and nutritional status in chilean children.
Conclusions. Prenatal growth influences MS, IR, and nutritional status. Prenatal growth was more important than present body composition in determining these outcomes. PMID: 25025054 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 19, 2014 Category: Research Authors: Mardones F, Arnaiz P, Pacheco P, Dominguez A, Villarroel L, Eriksson JG, Barja S, Farías M, Castillo O Tags: Biomed Res Int Source Type: research

Serum HDL-C level of Iranian adults: results from sixth national Surveillance of Risk Factors of Non-Communicable Disease.
CONCLUSIONS: High level of HDL-C among Iranian adults was shown in this study which can be a major reason of increasing incidence of heart diseases in Iran. Hence, formulating policy regulations and interventions in Iranian lifestyle to reduce HDL-C levels should be among top priorities for health politicians. PMID: 25028645 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - July 18, 2014 Category: Endocrinology Authors: Hosseini M, Navidi I, Yousefifard M, Heshmat R, Koohpayehzadeh J, Asgari F, Etemad K, Rafei A, Gouya MM Tags: J Diabetes Metab Disord Source Type: research

AMPK activation: a therapeutic target for type 2 diabetes?
Abstract Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have T2D, and the International Diabetes Federation projects that this number will increase to nearly 600 million by 2035. There is a great need for more effective treatments for maintaining glucose homeostasis and improving insulin sensitivity. AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase whose activation elicits insulin-sensitizing effects, making it an ideal therapeutic target for T2D. A...
Source: Diabetes Metab - July 18, 2014 Category: Endocrinology Authors: Coughlan KA, Valentine RJ, Ruderman NB, Saha AK Tags: Diabetes Metab Syndr Obes Source Type: research

Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity.
This study aimed to delineate the associations of the MetS with plasma PON1 activity, PON1 Q192R genotypes, smoking, and mood disorders (major depression and bipolar disorder), while adjusting for HDL cholesterol, body mass index, age, gender, and sociodemographic data. We measured plasma PON1 activity and serum HDL cholesterol and determined PON1 Q192R genotypes through functional analysis in 335 subjects, consisting of 97 with and 238 without MetS. The severity of nicotine dependence was measured using the Fagerström Nicotine Dependence Scale. Results PON1 Q192R functional genotypes and PON1 Q192R genotypes by smoking i...
Source: Redox Report : communications in free radical research - July 18, 2014 Category: Biochemistry Authors: Bortolasci CC, Vargas HO, Souza-Nogueira A, Gastaldello Moreira E, Vargas Nunes SO, Berk M, Dodd S, Barbosa DS, Maes M Tags: Redox Rep Source Type: research

Exercise-mediated vasodilation in human obesity and metabolic syndrome: Effect of acute ascorbic acid infusion.
In conclusion, AA infusion during rhythmic forearm exercise does not alter the time course or magnitude of exercise-mediated vasodilation in groups of young lean, obese, or MetSyn adults. However, systemic inflammation may limit the MRT to exercise, which can be improved with AA. PMID: 25038148 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 18, 2014 Category: Physiology Authors: Limberg JK, Kellawan JM, Harrell JW, Johansson R, Eldridge MW, Proctor LT, Sebranek JJ, Schrage WG Tags: Am J Physiol Heart Circ Physiol Source Type: research

Circadian clock desynchronisation and metabolic syndrome
There is emerging evidence in the literature to suggest that disruption of the normal circadian rhythm (sleep–wake cycle signalling) is a potential risk factor to explain the increased incidence of metabolic syndrome. Over the last century, obesity, diabetes and other components of metabolic syndrome have been on the rise. On the other hand, the amount of sleep has decreased from an average of 6–8 h per night. Furthermore, the quality of sleep has declined with more individuals voluntarily decreasing their amount of sleep to work or enjoy leisure activities. Over the last decade, researchers have examined ...
Source: Postgraduate Medical Journal - July 17, 2014 Category: Journals (General) Authors: Sheikh-Ali, M., Maharaj, J. Tags: Reviews Source Type: research

Predominant role of GIP in the development of a metabolic syndrome-like phenotype in female Wistar rats submitted to forced catch-up growth.
In conclusion, the exacerbated production and secretion of GIP after the catch-up growth seems to represent the stimulus for insulin hypersecretion and insulin resistance, ultimately resulting in derangement of glucose homeostasis. Overall, these data evidence the role of GIP as a critical link between catch-up growth and the development of metabolic disturbances. PMID: 25032669 [PubMed - as supplied by publisher] (Source: Endocrinology)
Source: Endocrinology - July 17, 2014 Category: Endocrinology Authors: De Toro-Martín J, Fernández-Millán E, Lizárraga-Mollinedo E, López-Oliva E, Serradas P, Escrivá F, Alvarez C Tags: Endocrinology Source Type: research

Circulating pathogen associated molecular pattern – Binding proteins and High Mobility Group Box protein 1 in nascent Metabolic Syndrome: Implications for cellular Toll-like receptor activity
(Source: Atherosclerosis)
Source: Atherosclerosis - July 17, 2014 Category: Cardiology Authors: I. Jialal, U. Rajamani, B. Adams-Huet, H. Kaur Source Type: research

Circulating irisin and GIP are associated with the development of polycystic ovary syndrome.
Conclusion: Although there is as yet no evidence for a causal link between irisin and/or GIP and PCOS, it is conceivable that irisin and GIP might contribute to the the develpment of PCOS and may also represent novel PCOS biomarkers. PMID: 25029417 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 16, 2014 Category: Endocrinology Authors: Chang CL, Huang SY, Soong YK, Cheng PJ, Wang CJ, Liang IT Tags: J Clin Endocrinol Metab Source Type: research

Lack of Association of Body Composition and Functionality Variables with Metabolic Syndrome in the Elderly
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - July 15, 2014 Category: Endocrinology Tags: article Source Type: research

Time window-dependent effect of perinatal maternal protein restriction on insulin sensitivity and energy substrate oxidation in adult male offspring
Epidemiological and experimental evidence suggests that a suboptimal environment during perinatal life programs offspring susceptibility to the development of metabolic syndrome and Type 2 diabetes. We hypothesized that the lasting impact of perinatal protein deprivation on mitochondrial fuel oxidation and insulin sensitivity would depend on the time window of exposure. To improve our understanding of underlying mechanisms, an integrative approach was used, combining the assessment of insulin sensitivity and untargeted mass spectrometry-based metabolomics in the offspring. A hyperinsulinemic-euglycemic clamp was performed ...
Source: AJP: Regulatory, Integrative and Comparative Physiology - July 15, 2014 Category: Physiology Authors: Agnoux, A. M., Antignac, J.-P., Simard, G., Poupeau, G., Darmaun, D., Parnet, P., Alexandre-Gouabau, M.-C. Tags: Obesity, Diabetes and Energy Homeostasis Source Type: research

Prevalence, components and associated demographic and lifestyle factors of the metabolic syndrome in type 2 diabetes mellitus
Background: Adults with the metabolic syndrome (MetS) are twice as likely to die from and three times as likely to have a heart attack or stroke compared with people without the syndrome. About 70-80% of type 2 diabetes mellitus (type 2 DM) patients are diagnosed with the MetS. Investigating the occurrence of the MetS in type 2 DM patients is critical for cardiovascular disease prevention. We evaluated the prevalence and components of the MetS and its associated clinical and demographic factors in a Ghanaian adult population with DM 2. Methods: This cross-sectional study was conducted among 200 previously diagnosed type 2 ...
Source: BioMed Central - July 15, 2014 Category: Journals (General) Authors: Victor MogreZenabankara S SalifuRobert Abedandi Source Type: research

Association of serum lead and mercury level with cardiometabolic risk factors and liver enzymes in a nationally representative sample of adolescents: the CASPIAN-III study.
This study aims to determine the difference of serum Pb and Hg levels in adolescents with or without metabolic syndrome (MetS) and the association of serum levels of these heavy metals with cardiometabolic risk factors and liver enzymes in Iranian adolescents. The study population consisted of 320 adolescents (160 with MetS and 160 healthy controls). The relationship between serum heavy metals and cardiometabolic risk factors was assessed by linear regression. The odds ratios (OR) of having metabolic syndrome across Pb and Hg quartiles were determined by multiple logistic regression analysis. The mean (SD) of Pb and Hg con...
Source: Environmental Science and Pollution Research International - July 15, 2014 Category: Environmental Health Authors: Poursafa P, Ataee E, Motlagh ME, Ardalan G, Tajadini MH, Yazdi M, Kelishadi R Tags: Environ Sci Pollut Res Int Source Type: research

The paradox of bardoxolone methyl: a call for every witness on the stand?
Abstract People with type 2 diabetes and chronic kidney disease remain an extremely vulnerable population with increased cardiovascular morbidity, mortality and mounting societal costs. As such, any effort to improve their dismal outcome is heavily supported. Yet, most drugs fail to replicate the promising signals of early experiments in humans in large and methodologically sound trials. As a recent example, an independent data and safety committee advised the termination of a Phase 3 trial due to excessive cardiovascular disease and especially heart failure in patients allocated to the anti‐oxidant synthetic triterpenoi...
Source: Diabetes, Obesity and Metabolism - July 14, 2014 Category: Endocrinology Authors: Steven Van Laecke, Wim Van Biesen, Raymond Vanholder Tags: REVIEW ARTICLE Source Type: research

Do apolipoproteins improve coronary risk prediction in subjects with metabolic syndrome? Insights from the North Italian Brianza cohort study.
(Source: Atherosclerosis)
Source: Atherosclerosis - July 14, 2014 Category: Cardiology Authors: Francesco Gianfagna, Giovanni Veronesi, Luigina Guasti, Lloyd E. Chambless, Paolo Brambilla, Giovanni Corrao, Giuseppe Mancia, Giancarlo Cesana, Marco M. Ferrario Source Type: research

Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation.
CONCLUSION: Non-obese LT recipients have similar pro-atherosclerotic serum profiles after a short 1-year follow-up period compared to NASH patients, suggesting a high risk of atherosclerosis in this population. PMID: 25024624 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Alvares-da-Silva MR, de Oliveira CP, Stefano JT, Barbeiro HV, Barbeiro D, Soriano FG, Farias AQ, Carrilho FJ, Carneiro D'Albuquerque LA Tags: World J Gastroenterol Source Type: research

Experimental models of non-alcoholic fatty liver disease in rats.
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, and it persists at a high prevalence. NAFLD is characterised by the accumulation of triglycerides in the liver and includes a spectrum of histopathological findings, ranging from simple fatty liver through non-alcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis, which may progress to hepatocellular carcinoma. The pathogenesis of NAFLD is closely related to the metabolic syndrome and insulin resistance. Understanding the pathophysiology and treatment of NAFLD in humans has currently bee...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Kucera O, Cervinkova Z Tags: World J Gastroenterol Source Type: research

Nonalcoholic fatty liver disease and polycystic ovary syndrome.
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the Western world comprising a spectrum of liver damage from fatty liver infiltration to end-stage liver disease, in patients without significant alcohol consumption. Increased prevalence of NAFLD has been reported in patients with polycystic ovary syndrome (PCOS), one of the most common endocrinopathies in premenopausal women, which has been redefined as a reproductive and metabolic disorder after the recognition of the important role of insulin resistance in the pathophysiology of the syndrome. Obesity, in parti...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Vassilatou E Tags: World J Gastroenterol Source Type: research

Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis.
Abstract Non-alcoholic fatty liver disease (NAFLD) is a widely prevalent hepatic disorder that covers wide spectrum of liver pathology. NAFLD is strongly associated with liver inflammation, metabolic hyperlipidaemia and insulin resistance. Frequently, NAFLD has been considered as the hepatic manifestation of metabolic syndrome. The pathophysiology of NAFLD has not been fully elucidated. Some patients can remain in the stage of simple steatosis, which generally is a benign condition; whereas others can develop liver inflammation and progress into non-alcoholic steatohepatitis, fibrosis, cirrhosis and hepatocellular ...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Lim JW, Dillon J, Miller M Tags: World J Gastroenterol Source Type: research

Metabolic syndrome delays HBeAg seroclearance in Chinese patients with hepatitis B
ConclusionChinese patients with chronic hepatitis B and with pre‐metabolic syndrome or metabolic syndrome have delayed HBeAg seroclearance. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 13, 2014 Category: Drugs & Pharmacology Authors: J. C. Hsiang, G. L.‐H. Wong, H. L.‐Y. Chan, A. W.‐H. Chan, A. M.‐L. Chim, V. W.‐S. Wong Tags: Original Article Source Type: research

Progression of Kidney Injury and Cardiac Remodeling in Obese Spontaneously Hypertensive Rats: The Role of Renal Sympathetic Innervation.
CONCLUSIONS: In SHRs-ob, progressive increase in blood pressure and progression of renal injury and cardiac remodelling are mediated by renal sympathetic activation as they were attenuated by RDN. PMID: 25023205 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 13, 2014 Category: Cardiology Authors: Linz D, Hohl M, Schütze J, Mahfoud F, Speer T, Linz B, Hübschle T, Juretschke HP, Dechend R, Geisel J, Rütten H, Böhm M Tags: Am J Hypertens Source Type: research

Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis
Conclusion IR increases plaque vulnerability by augmenting the CX3CL1/CX3CR1 axis, which is mechanistically linked to reduced VSMC survival. Thus, modulation of IRS2-dependent signalling emerges as a potential therapeutic strategy to promote VSMC survival and atheroma plaque stability and to reduce inflammatory mediators in IR–MetS. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 12, 2014 Category: Cardiology Authors: Martinez-Hervas, S., Vinue, A., Nunez, L., Andres-Blasco, I., Piqueras, L., Real, J. T., Ascaso, J. F., Burks, D. J., Sanz, M. J., Gonzalez-Navarro, H. Tags: Vascular biology Source Type: research

Vanadium Methyl-Bipyridine Organoligand and its Influence on Energy Balance and Organs Mass.
Abstract In the treatment of lifestyle diseases, including metabolic syndrome and type 2 diabetes, it is important to lower body mass and fat tissue, and consequently, to increase insulin-sensitivity. Unfortunately, it often happens that low-energy diet which would lower overweight is not observed and, thus, it does not bring the expected effects. This paper discusses the influence of three diets-control, high-fructose, and high-fatty diet-on absorption of energy from food in order to transform it into body mass. The kJ/g ratio which describes this process has been calculated. In the tested diets, the addition of f...
Source: Biological Trace Element Research - July 12, 2014 Category: Biology Authors: Krośniak M, Francik R, Wojtanowska-Krośniak A, Tedeschi C, Krasoń-Nowak M, Chłopicka J, Gryboś R Tags: Biol Trace Elem Res Source Type: research

Association between Apolipoprotein B/Apolipoprotein A-1 and arterial stiffness in metabolic syndrome.
CONCLUSION:: These results suggest that Apo B/Apo A-1 is independently associated with increased arterial stiffness in patients with MetS. PMID: 25025299 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - July 12, 2014 Category: Chemistry Authors: Kim MK, Ahn CW, Kang S, Ha JY, Baek H, Park JS, Kim KR Tags: Clin Chim Acta Source Type: research

Recent developments in kidney transplantation in children.
Abstract PURPOSE OF REVIEW: Renal transplantation in childhood is a well established procedure with excellent short-term outcomes. However, waiting times for transplantation are still relatively long if living donation cannot be performed, and long-term outcomes after transplantation have not significantly improved during the last decade. RECENT FINDINGS: This review describes alternative modalities to improve donation rates such as en bloc kidney transplantation from young donors, ABO-incompatible transplantation and kidney paired donation. This review also deals with long-term post-transplant morbidities, suc...
Source: Current Opinion in Organ Transplantation - July 11, 2014 Category: Transplant Surgery Authors: Rusai K, Szabo AJ Tags: Curr Opin Organ Transplant Source Type: research

Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet - the RESOLVE Trial
Conclusions: Lipoprotein subfractions traditionally involved in CVR, decreased after the 3-week residential program. During a 12 month follow-up, the time-related regains remained closer to the values of healthy controls than they were at baseline. CIMT improved throughout the lifestyle intervention. However, we failed to demonstrate a link between some lipoprotein subfractions and the atherogenicity directly measured from the wall thickness of arteries (CIMT). Further investigations are required to explore the atherogenicity of lipoprotein subfractions.Trial registration: NCT00917917 (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - July 11, 2014 Category: Lipidology Authors: Frédéric DutheilGuillaume WaltherRobert ChapierGeorge MnatzaganianBruno LesourdGeraldine NaughtonJulien VerneyAnne FogliVincent SapinMartine DuclosAgnès VinetPhilippe ObertDaniel CourteixGérard Lac Source Type: research

Improving Long-Term Outcomes After Liver Transplantation
Long-term survival following liver transplantation is profoundly affected by conditions unrelated to graft function. Many causes of mortality are contributed to by the metabolic syndrome. The approach to metabolic syndrome in liver transplant recipients requires consideration of transplant-specific factors, particularly immunosuppression. Enhancing long-term outcomes for liver transplant recipients necessitates minimizing the amount of immunosuppression required to prevent rejection. Studies to determine the optimal approach to minimize the impact of metabolic syndrome and complications of immunosuppression in transplant r...
Source: Clinics in Liver Disease - July 10, 2014 Category: Gastroenterology Authors: Michael R. Charlton Source Type: research

Insulin, NF-{kappa}B, and Myocardin Signaling in Cardiac Myoblasts [Signal Transduction]
Hyperinsulinemia contributes to cardiac hypertrophy and heart failure in patients with the metabolic syndrome and type 2 diabetes. Here, high circulating levels of tumor necrosis factor (TNF)-α may synergize with insulin in signaling inflammation and cardiac hypertrophy. We tested whether high insulin affects activation of TNF-α-induced NF-κB and myocardin/serum response factor (SRF) to convey hypertrophy signaling in cardiac myoblasts. In canine cardiac myoblasts, treatment with high insulin (10−8 to 10−7 m) for 0–24 h increased insulin receptor substrate (IRS)-1 phosphorylation at Ser-307, decreased protein leve...
Source: Journal of Biological Chemistry - July 10, 2014 Category: Chemistry Authors: Madonna, R., Geng, Y.-J., Bolli, R., Rokosh, G., Ferdinandy, P., Patterson, C., De Caterina, R. Tags: Gene Regulation Source Type: research

Effect of Long Term Vitamin D Supplementation on Biomarkers of Inflammation in Latino and African-American Subjects with Pre-Diabetes and Hypovitaminosis D.
Abstract Low vitamin D levels are associated with minority subjects, the metabolic syndrome, and inflammation. The effect of vitamin D supplementation on markers of inflammation has not been well studied. The aim of the study was to evaluate the effects of high doses of vitamin D supplementation for 1 year on serum biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Latino (n=69) and African-American (n=11) subjects who had both pre-diabetes and hypovitaminosis D with a mean age of 52.0 years, a BMI of 32.7 kg/m(2), and 70% of whom were females, were randomi...
Source: Diabetes Metab - July 10, 2014 Category: Endocrinology Authors: Sinha-Hikim I, Duran P, Shen R, Lee M, Friedman TC, Davidson MB Tags: Horm Metab Res Source Type: research

Baseline Levels, and Changes Over Time in Body Mass Index and Fasting Insulin, and Their Relationship to Change in Metabolic Trait Clustering
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - July 9, 2014 Category: Endocrinology Tags: article Source Type: research

Metabolic Syndrome Among Urban Indian Young Adults: Prevalence and Associated Risk Factors
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - July 9, 2014 Category: Endocrinology Tags: article Source Type: research

Metabolic Syndrome Appears Early After Hematopoietic Cell Transplantation
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - July 9, 2014 Category: Endocrinology Tags: article Source Type: research

Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans
Conclusions: These results implied that the minor allele effects of lipid-associated variants may predispose TE type subjects to high cardiovascular disease risk because of their genetic susceptibility to lipid-related disorders. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - July 9, 2014 Category: Complementary Medicine Authors: Sun-Ku ChungHyunjoo YuAh Yeon ParkJong Yeol KimSeongwon Cha Source Type: research

Metabolic Syndrome Among Urban Indian Young Adults: Prevalence and Associated Risk Factors.
Conclusion: The prevalence of metabolic syndrome is high among urban young adults in India, and it increased with increase in body mass index (BMI). Each component risk factor in isolated form-increased BMI, smoking, and history of hypertension-is an associated risk factor for metabolic syndrome. Although it is unclear whether metabolic syndrome screening in young Indians as a means to prevent adverse cardiovascular health outcomes is appropriate, healthy lifestyles should nevertheless be encouraged, and young adults should be considered as an important group for cardiovascular risk reduction programs. PMID: 25007135 [...
Source: Diabetes Metab - July 9, 2014 Category: Endocrinology Authors: Manjunath D, Uthappa CK, Kattula SR, Allam RR, Chava N, Oruganti G Tags: Metab Syndr Relat Disord Source Type: research

Baseline Levels, and Changes Over Time in Body Mass Index and Fasting Insulin, and Their Relationship to Change in Metabolic Trait Clustering.
Conclusions: Change in metabolic trait clustering was significantly associated with baseline levels and changes in both BMI and fasting insulin, highlighting the importance of both obesity and IR in the clustering of metabolic traits. PMID: 25007010 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - July 9, 2014 Category: Endocrinology Authors: Rutter MK, Sullivan LM, Fox CS, Wilson PW, Nathan DM, Vasan RS, D'Agostino RB, Meigs JB Tags: Metab Syndr Relat Disord Source Type: research

P-wave dispersion and maximum duration are independently associated with insulin resistance in metabolic syndrome.
CONCLUSION: This study suggests that patients with MS have a prolonged PWD and Pmax. The increase in these parameters may be an indicator for identification of patients at an increased risk for atrial fibrillation. PMID: 25016562 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - July 9, 2014 Category: Endocrinology Authors: Wang W, Zhang F, Xhen J, Chen X, Fu F, Tang M, Chen L Tags: Ann Endocrinol (Paris) Source Type: research

Grading scale of visceral adipose tissue thickness and their relation to the nonalcoholic fatty liver disease
Conclusions The visceral fat thickness measured by ultrasonography is a useful and seems to be able to help estimate the risk of NAFLD. Contexto A gordura mesentérica é drenada pelo sistema venoso portal, estando relacionada à síndrome metabólica, que é um importante fator de risco para doença de infiltração gordurosa do fígado. Objetivos Graduar a espessura do tecido adiposo visceral e correlacionar com o grau de doença de infiltração gordurosa do fígado através do exame ultrassonográfico. Métodos Foram estudados 352 indivíduos, avaliando-se idade, gênero, medidas da espessura da gordura subcutânea e...
Source: Arquivos de Gastroenterologia - July 8, 2014 Category: Gastroenterology Source Type: research

Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia
Conclusions Our preclinical results validate DES as a promising therapeutic approach to diabetes and obesity, which offers reversibility, low risk, low invasiveness and triple benefits including fat mass loss, glucose and lipid metabolism improvement which mechanistically may involve increased villus growth in the upper gut. (Source: Gut)
Source: Gut - July 8, 2014 Category: Gastroenterology Authors: Habegger, K. M., Al-Massadi, O., Heppner, K. M., Myronovych, A., Holland, J., Berger, J., Yi, C.-X., Gao, Y., Lehti, M., Ottaway, N., Amburgy, S., Raver, C., Muller, T. D., Pfluger, P. T., Kohli, R., Perez-Tilve, D., Seeley, R. J., Tschop, M. H. Tags: Small bowel Source Type: research

St. John's Wort Promotes Adipocyte Differentiation and Modulates NF-κB Activation in 3T3-L1 Cells.
Abstract St. John's wort (SJW), or Hypericum perforatum, is a perennial herb that has been used in the treatment of depression in several countries. Though its therapeutic effect on depression has been extensively studied, its influence on metabolic syndrome is yet to be fully characterized. Therefore, we investigated the effect of SJW extract on adipocyte differentiation and its anti-inflammatory effects by using 3T3-L1 preadipocytes. Oil Red O staining indicated that SJW promotes adipocyte differentiation, while immunoblots indicated that SJW increases the expression of peroxisome proliferator activated receptor ...
Source: Biological and Pharmaceutical Bulletin - July 7, 2014 Category: Drugs & Pharmacology Authors: Hatano T, Sameshima Y, Kawabata M, Yamada S, Shinozuka K, Nakabayashi T, Mizuno H Tags: Biol Pharm Bull Source Type: research

Quantitative analysis of pancreatic echogenicity on transabdominal sonography: Correlations with metabolic syndrome
ConclusionsWe quantitatively analyzed pancreatic echogenicity using the PPHFI on US and found that an increased PPHFI was significantly correlated with MetS. Because increased PPHFI on US may indicate MetS, radiologists and clinicians need to be aware of its implications. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound, 2014 (Source: Journal of Clinical Ultrasound)
Source: Journal of Clinical Ultrasound - July 7, 2014 Category: Radiology Authors: Hyeon Tae Jeong, Mu Sook Lee, Myeong‐Jin Kim Tags: Research Article Source Type: research

Association between waist‐to‐height ratio and chronic kidney disease in the Taiwanese population
ConclusionWHtR appears to be a better measure of central obesity than BMI, and is an easy‐to‐use, noninvasive tool for identifying individuals at risk of developing obesity‐related CKD, and potentially also MS‐related CKD. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - July 7, 2014 Category: Internal Medicine Authors: W.‐C. Li, J.‐Y. Chen, Y.‐Y. Lee, Y.‐M. Weng, C.‐T. Hsiao, S.‐S. Loke Tags: Original Article Source Type: research

Testosterone and mortality
Summary Epidemiological studies have found that men with low or low normal endogenous testosterone are at an increased risk of mortality than those with higher levels. Cardiovascular disease accounts for the greater proportion of deaths in those with low testosterone. Cancer and respiratory deaths in some of the studies are also significantly more prevalent. Disease‐specific studies have identified that there are higher mortality rates in men with cardiovascular, respiratory and renal diseases, type 2 diabetes and cancer with low testosterone. Obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease and infla...
Source: Clinical Endocrinology - July 7, 2014 Category: Endocrinology Authors: Vakkat Muraleedharan, T. Hugh Jones Tags: Requested Review Source Type: research

Increased Body Mass Index in Young Adults is Associated with Metabolic Syndrome.
Conclusion: BMI change in young adults is an important risk factor for MetS among individuals in their 40s. Even subjects with a BMI lower than 25 had differences in the risk of developing MetS based on their BMI change sub-group. In the field of occupational health, it will be necessary to promote stable weight control in young adults to reduce the incidence of MetS. PMID: 24999022 [PubMed - as supplied by publisher] (Source: Sangyo Eiseigaku Zasshi : Journal of Occupational Health)
Source: Sangyo Eiseigaku Zasshi : Journal of Occupational Health - July 7, 2014 Category: Occupational Health Authors: Kadoya M, Nakamura S, Sugio Y, Hiraoka H, Kurita M, Harada A, Matsumoto M, Nakanishi R, Sugiura T Tags: Sangyo Eiseigaku Zasshi Source Type: research

Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity
Conclusion: The MSD improves the BMI, glucose and lipid profile in children and adolescents with obesity and any MetS component. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - July 5, 2014 Category: Pediatrics Authors: Lubia Velázquez-LópezGerardo Santiago-DíazJulia Nava-HernándezAbril Muñoz-TorresPatricia Medina-BravoMargarita Torres-Tamayo Source Type: research