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Comprehensive Cardiovascular Risk Reduction and Cardiac Rehabilitation in Diabetes and the Metabolic Syndrome
Publication date: Available online 22 July 2016 Source:Canadian Journal of Cardiology Author(s): Robert E. Heinl, Devinder S. Dhindsa, Elliot N. Mahlof, William M. Schultz, John Ricketts, Tina Varghese, Amirhossein Esmaeeli, Marc P. Allard-Ratick, Anthony J. Millard, Heval M. Kelli, Pratik B. Sandesara, Danny J. Eapen, Laurence Sperling The epidemic of obesity has contributed to a growing burden of metabolic syndrome (MetS) and diabetes (DM) worldwide. MetS is defined as central obesity along with associated factors such as hypertriglyceridemia, low high-density lipoprotein (HDL-C), hyperglycemia, and hypert...
Source: Canadian Journal of Cardiology - July 24, 2016 Category: Cardiology Source Type: research

Heme oxygenase levels and metaflammation in benign prostatic hyperplasia patients
Conclusion < /h3 > < p class= " a-plus-plus " > MetS-induced inflammation may play a key role in BPH. In detail, prostate metaflammation is inversely related to intra-prostatic HO-1 levels, serum HDL and positively with triglycerides. < /p > < /span > (Source: World Journal of Urology)
Source: World Journal of Urology - July 23, 2016 Category: Urology & Nephrology Source Type: research

Serum vitamin A status is associated with obesity and the metabolic syndrome among school-age children in Chongqing, China.
Abstract The aim of our study was to examine the association of vitamin A status with obesity and the metabolic syndrome (MS) in school-age children in Chongqing, China. A cross-sectional study was conducted of 1,928 children aged 7~11 years from 5 schools in Chongqing, China. Body height, weight, waist circumference (WC) and blood pressure were measured. Blood glucose, lipids and vitamin A were determined. Overall prevalences for overweight, obesity and MS were 10.1%, 6.7% and 3.5%, respectively. There were 274 (14.2%) marginally vitamin A deficient (MVAD) children and 53 (2.8%) vitamin A deficient (VAD) children,...
Source: Asia Pacific Journal of Clinical Nutrition - July 23, 2016 Category: Nutrition Authors: Wei X, Peng R, Cao J, Kang Y, Qu P, Liu Y, Xiao X, Li T Tags: Asia Pac J Clin Nutr Source Type: research

Molecules, Vol. 21, Pages 966: Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases
Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been well characterized. The potential applications of capsaicin range from food flavorings to therapeutics. Indeed, capsaicin and few of its analogues have featured in clinical research covered by more than a thousand patents. Previous records suggest pleiotropic pharmacological activities of capsaicin such as an analgesic, anti-obesity, anti-pruritic, anti-inflammatory, anti-apoptotic, anti-cancer, anti-oxidant, and neuro-protective functions. Moreov...
Source: Molecules - July 23, 2016 Category: Chemistry Authors: Shaherin Basith Minghua Cui Sunhye Hong Sun Choi Tags: Review Source Type: research

Is the Association between Vitamin D and Metabolic Syndrome Independent of Other Micronutrients.
Authors: Khosravi-Boroujeni H, Ahmed F, Sarrafzadegan N Abstract The incidence of metabolic syndrome (MetS) has been increasing globally and it is recognized as a major public health problem because MetS is associated with increased risk of diabetes, stroke, cancer, and other chronic diseases. Recently, MetS has been linked to vitamin D deficiency. However, the evidence on the association between vitamin D deficiency and the risk of MetS remains inconclusive. This review therefore aims to depict the existing evidence related to MetS and vitamin D deficiency, and examined some of the possible confounders which may a...
Source: International Journal for Vitamin and Nutrition Research - July 22, 2016 Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research

Autoimmune diabetes in adults and risk of myocardial infarction: the HUNT study in Norway
ConclusionsWomen with AIDA were more likely to develop MI, compared to men with AIDA and both men and women with type 2 diabetes. Further investigations are warranted to confirm this gender difference. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - July 22, 2016 Category: Internal Medicine Authors: L. E. Laugsand, I. Janszky, L. J. Vatten, H. Dalen, K. Midthjell, V. Grill, S. Carlsson Tags: Original Article Source Type: research

The Effects of Folate Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Patients with Metabolic Syndrome
Conclusions: < /i > < /b > Overall, 5 mg/day folate supplementation for 12 weeks among patients with MetS had beneficial effects on CIMT and the metabolic status. < br / > Ann Nutr Metab 2016;69:41-50 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - July 22, 2016 Category: Nutrition Source Type: research

[University students' ’ cardiovascular risk factors and their relationship with body composition].
CONCLUSION: Cardiovascular risk factors had high prevalence in this sample of undergraduate students due to alterations in their blood, lipid profile and anthropometric changes, suggesting that modifications must be made regarding their lifestyles and body composition. PMID: 25791302 [PubMed - in process] (Source: Revista de Salud Publica)
Source: Revista de Salud Publica - July 22, 2016 Category: Global & Universal Tags: Rev Salud Publica (Bogota) Source Type: research

Associations between school meal-induced dietary changes and metabolic syndrome markers in 8 –11-year-old Danish children
Conclusions < /h3 > < p class= " a-plus-plus " > DHA in whole-blood, an indicator of DHA and fish intake, seemed to be the main diet-related predictor of the beneficial effects of the school meals on MetS markers. Increased potato intake was associated with increased waist circumference, but this may not only be due to an increase in abdominal fat, as no association was seen with fat distribution. < /p > < /span > (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - July 22, 2016 Category: Nutrition Source Type: research

Increased depression and metabolic risk in postmenopausal breast cancer survivors
Breast cancer survivors (BCS) are at high risk for the development of obesity, type 2 diabetes mellitus, and metabolic syndrome. There is increasing interest in the association between depression and metabolic... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - July 22, 2016 Category: Endocrinology Authors: Monica C. Serra, Andrew P. Goldberg and Alice S. Ryan Source Type: research

Hemoglobin A1c as screening for gestational diabetes mellitus in Nordic Caucasian women
Gestational diabetes mellitus (GDM) increases the risk for preeclampsia and macrosomia. GDM is conventionally diagnosed by an oral glucose tolerance test (OGTT). Hemoglobin A1c (HbA1c) is a marker for the aver... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - July 22, 2016 Category: Endocrinology Authors: Ingrid Hov Ods æter, Arne Åsberg, Eszter Vanky, Siv Mørkved, Signe Nilssen Stafne, Kjell Åsmund Salvesen and Sven Magnus Carlsen Source Type: research

A study for association and interaction analysis to metabolic syndrome and the ESR1 gene on cardiovascular autonomic neuropathy in a Chinese Han population
The aim of this study was to investigate the association and interaction of metabolic syndrome (MetS) and estrogen receptor alpha 1 (ESR1) gene polymorphisms on cardiovascular autonomic neuropathy (CAN). (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - July 22, 2016 Category: Endocrinology Authors: Fangfang Zeng, Linuo Zhou and Zihui Tang Source Type: research

The influence of goutweed (Aegopodium podagraria L.) tincture and metformin on the carbohydrate and lipid metabolism in dexamethasone-treated rats
Diabetes mellitus and metabolic syndrome are the common problems of the modern society. The interest in herbal medicines increases, and often they are used in combination with conventional drugs. Aegopodium podag... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - July 22, 2016 Category: Complementary Medicine Authors: O. V. Tovchiga Source Type: research

Challenges associated with insulin therapy progression among patients with type 2 diabetes: Latin American MOSAIc study baseline data
Poor glycemic control in patients with type 2 diabetes is commonly recorded worldwide; Latin America (LA) is not an exception. Barriers to intensifying insulin therapy and which barriers are most likely to neg... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - July 22, 2016 Category: Endocrinology Authors: Bruno Linetzky, Brad Curtis, Gustavo Frechtel, Renan Montenegro, Miguel Escalante Pulido, Oded Stempa, Janaina Martins de Lana and Juan Jos é Gagliardino Source Type: research

Association of obesity with hypertension and dyslipidemia in type 2 diabetes mellitus subjects
Conclusions Females were more susceptible to obesity. Hypertension was associated with both obesity measures. Dyslipidemia, except for hypertriglyceridemia, was correlated to neither abdominal nor general obesity. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 22, 2016 Category: Endocrinology Source Type: research

Association of metabolic syndrome and 25 ‐hydroxyvitamin D with cognitive impairment among elderly Koreans
ConclusionsMetabolic syndrome was associated with cognitive impairment, and this risk was synergistically increased when metabolic syndrome was combined with low 25(OH)D. A focus on individuals with metabolic syndrome and low 25(OH)D might be helpful to identify older adults who are at risk of cognitive impairment. Geriatr Gerontol Int 2016; ••: ••–••. (Source: Geriatrics and Gerontology International)
Source: Geriatrics and Gerontology International - July 22, 2016 Category: Geriatrics Authors: Eun Young Lee, Su Jin Lee, Kyoung Min Kim, Young Mi Yun, Bo Mi Song, Jong Eun Kim, Hyeon Chang Kim, Yumie Rhee, Yoosik Youm, Chang Oh Kim Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Hepatic Safety of Atypical Antipsychotics: Current Evidence and Future Directions
< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > The newer atypical antipsychotic agents (AAPs) represent an attractive therapeutic option for a wide range of psychotic disorders, including schizophrenia and bipolar mania, because of the reduced risk of disabling extrapyramidal symptoms. However, their growing use has raised questions about their tolerability over the endocrine, metabolic, and cardiovascular axes. Indeed, atypical antipsychotic drugs are associated, to differing extents, with mild elevation of aminotransferases related to weight gain, AAP-induced metabolic syndrome, and nonalcoho...
Source: Drug Safety - July 22, 2016 Category: Drugs & Pharmacology Source Type: research

Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome
Conclusion Circulating chemerin was increased in overweight compared with normal weight PCOS patients. The most predictive variables for circulating chemerin in PCOS patients were BMI, FAI and age. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - July 22, 2016 Category: Research Authors: Guvenc, Y., Var, A., Goker, A., Kuscu, N. K. Tags: Research Reports Source Type: research

Current status of health among workers in Japan: Results from the Japan Epidemiology Collaboration on Occupational Health Study.
Authors: Kuwahara K, Uehara A, Yamamoto M, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Sasaki N, Ogasawara T, Hori A, Nishiura C, Miyamoto T, Kochi T, Eguchi M, Tomita K, Imai T, Nishihara A, Nagahama S, Murakami T, Shimizu M, Kabe I, Mizoue T, Kunugita N, Sone T, Dohi S, Group Japan Epidemiology Collaboration on Occupational Health Study Abstract Data are limited on the sex-specific prevalence of diseases and their risk factors in middle-aged and older workers in Japan. In this cross-sectional study, we investigated the age- and sex-specific prevalence of hypertension, diabetes, dyslipidemia, metabolic syndrome (d...
Source: Industrial Health - July 21, 2016 Category: Occupational Health Tags: Ind Health Source Type: research

Influence of Helicobacter pylori Infection on Metabolic Syndrome in Old Chinese People.
Conclusions. Patients with H. pylori infection had higher BMI and fasting glucose levels and had incidence of metabolic syndrome. PMID: 27429613 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - July 21, 2016 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD
Ectopic lipid accumulation in the liver is an almost universal feature of human and rodent models of generalized lipodystrophy and is also a common feature of type 2 diabetes, obesity, and metabolic syndrome. Here we explore the progression of fatty liver disease using a mouse model of lipodystrophy created by a fat-specific knockout of the insulin receptor (F-IRKO) or both IR and insulin-like growth factor 1 receptor (F-IR/IGFRKO). These mice develop severe lipodystrophy, diabetes, hyperlipidemia, and fatty liver disease within the first weeks of life. By 12 weeks of age, liver demonstrated increased reactive oxygen speci...
Source: Diabetes - July 21, 2016 Category: Endocrinology Authors: Softic, S.; Boucher, J.; Solheim, M. H.; Fujisaka, S.; Haering, M.-F.; Homan, E. P.; Winnay, J.; Perez-Atayde, A. R.; Kahn, C. R. Tags: Metabolism Source Type: research

Renal Denervation for Resistant Hypertension Fails to Improve Insulin Resistance as Assessed by Hyperinsulinemic-Euglycemic Step Clamp
We assessed whether insulin sensitivity improved after renal denervation (RDN) for resistant hypertension. Twenty-three patients underwent a two-step hyperinsulinemic-euglycemic clamp (HEC) with glucose tracer and labeled glucose infusion and oral glucose tolerance test (OGTT) before and 6 months after RDN. Eighteen patients had metabolic syndrome at baseline. Blood pressure declined significantly after RDN, whereas mean (SD) fasting plasma glucose concentration (5.9 ± 0.7 mmol/L), median (minimum–maximum) insulin concentration (254 pmol/L [88–797 pmol/L]), and median C-peptide concentration (2.4 nmol/L ...
Source: Diabetes - July 21, 2016 Category: Endocrinology Authors: Miroslawska, A. K.; Gjessing, P. F.; Solbu, M. D.; Fuskevag, O. M.; Jenssen, T. G.; Steigen, T. K. Tags: Metabolism Source Type: research

Involvement of adropin and adropin-associated genes in metabolic abnormalities of hemodialysis patients
We examined the involvement of plasma adropin and adropin-associated genes (ENHO and RXRA) in metabolic abnormalities of hemodialysis (HD) patients. Main methods Among 50 HD patients (27 males and 23 females, aged 65.2±12.6years, HD vintage 29.0, 3.9–157.0months), there were 26 dyslipidemics and 25 type 2 diabetics. Age-matched healthy subjects (n =26) served as controls. Adropin levels were determined using ELISA. Insulin resistance/sensitivity was assessed using the Homeostasis Model Assessment for Insulin Resistance and Quantitative Insulin Sensitivity Check Index. ENHO (rs2281997, rs72735260) and RXRA (rs10881578, ...
Source: Life Sciences - July 21, 2016 Category: Biology Source Type: research

Treatment of Hyperlipidemia Changes With Level of Kidney Function —Rationale
Publication date: July 2016 Source:Advances in Chronic Kidney Disease, Volume 23, Issue 4 Author(s): Shubha Ananthakrishnan, George A. Kaysen Lipoprotein abnormalities such as low levels of high-density lipoprotein (HDL) and high triglycerides (TGs), associated with the metabolic syndrome, are also associated with subsequent decline in kidney function. Patients with end-stage kidney disease also exhibit low HDL and high TGs and a modest reduction in low-density lipoprotein (LDL), although the mechanisms responsible for these changes differ when patients with end-stage kidney disease are compared with those having metab...
Source: Advances in Chronic Kidney Disease - July 21, 2016 Category: Urology & Nephrology Source Type: research

Metabolic syndrome and retinal microvascular calibre in a high cardiovascular disease risk cohort
Conclusions Metabolic syndrome is independently associated with narrower retinal arterioles but not wider retinal venules among those at high risk of CAD. The association between metabolic syndrome and narrower retinal arterioles is likely due to the presence of CAD or hypertension in individuals with this syndrome, as the association is not significant in individuals without hypertension or without CAD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Wang, S. B., Mitchell, P., Plant, A. J. H., Phan, K., Liew, G., Thiagalingam, A., Burlutsky, G., Gopinath, B. Tags: Public health Original articles - Clinical science Source Type: research

Relationship between functional capacity and health-related quality of life of patients with type —2 diabetes
Conclusion Patients with T2D demonstrated low functional capacity and reduced HRQoL. Significant relationship exists between FC and physical and mental component summary of HRQoL. Exercise intervention to improve FC and HRQoL were recommended. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 21, 2016 Category: Endocrinology Source Type: research

Bile acid-lowering properties of Lactobacillus plantarum Sanriku –SU3 isolated from Japanese surfperch fish
Publication date: 1 June 2016 Source:Food Bioscience, Volume 14 Author(s): Takashi Kuda, Yurie Masuko, Miho Kawahara, Saya Kondo, Maki Nemoto, Toru Nakata, Manami Kataoka, Hajime Takahashi, Bon Kimura In vitro bile acid-lowering capacity of lactic acid bacteria (LAB) strains (ten Lactobacillus plantarum, four Lactococcus lactis, and two Leuconostoc mesenteroides) isolated from fermented fish and fish intestine were compared with those of type strains. Among the isolated strains, Lb. plantarum Sanriku–SU3, Lc. lactis Suzuki 8, and Ln. mesenteroides BF6, isolated from Japanese surfperch, Japanese seabass, and Ko...
Source: Food Bioscience - July 21, 2016 Category: Food Science Source Type: research

Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase
In conclusion, adipocyte-MR upregulation leads to impaired contractility with preserved endothelial function and normal blood pressure. Increased elasticity may contribute to hypocontractility. We also identify functional cross talk between adipocyte MR and arteries and describe novel mechanisms involving redox-sensitive PKG-1 and Rho kinase. Our results suggest that adipose tissue from Adipo-MROE secrete vasoactive factors that preferentially influence vascular smooth muscle cells rather than endothelial cells. Our findings may be important in obesity/adiposity where adipocyte-MR expression/signaling is amplified and vasc...
Source: Diabetes - July 21, 2016 Category: Endocrinology Authors: Nguyen Dinh Cat, A.; Antunes, T. T.; Callera, G. E.; Sanchez, A.; Tsiropoulou, S.; Dulak-Lis, M. G.; Anagnostopoulou, A.; He, Y.; Montezano, A. C.; Jaisser, F.; Touyz, R. M. Tags: Pathophysiology Source Type: research

Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study
This study investigated whether functional brain networks are affected in type 2 diabetes and prediabetes. Forty-seven participants with diabetes, 47 participants with prediabetes, and 45 control participants underwent detailed cognitive testing and 3-Tesla resting state functional MRI. Graph theoretical network analysis was performed to investigate alterations in functional cerebral networks. Participants with diabetes displayed altered network measures, characterized by a higher normalized cluster coefficient and higher local efficiency, compared with control participants. The network measures of the participants with pr...
Source: Diabetes - July 21, 2016 Category: Endocrinology Authors: van Bussel, F. C. G.; Backes, W. H.; van Veenendaal, T. M.; Hofman, P. A. M.; van Boxtel, M. P. J.; Schram, M. T.; Sep, S. J. S.; Dagnelie, P. C.; Schaper, N.; Stehouwer, C. D. A.; Wildberger, J. E.; Jansen, J. F. A. Tags: Pathophysiology Source Type: research

Highlights from this issue
Semoun et al (see page 1028) In a retrospective descriptive study of 30 patients, en face OCT imaging using SD-OCT was observed to be an easy, reproducible and non-invasive tool to visualise and to understand retinal and choroidal changes in PCV. Kim et al (see page 1035) In an observational, comparative study of 134 patients with idiopathic ERM and 63 healthy controls, temporal peripapillary retinal nerve fiber layer thickness was significantly greater, especially when the ERM extended into the peripapillary area. Gopinath et al (see page 1041) Metabolic syndrome is independently associated with narrower retinal arteriole...
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

Glycated apolipoprotein B —A surrogate marker of subclinical atherosclerosis
Conclusion Persistent hyperglycemia and sdLDL are independently associated with glycation of apo B. Presence of plaques and increased thickness of intima indicates that glycated apo B predisposes diabetics to atherosclerosis. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 21, 2016 Category: Endocrinology Source Type: research

Endocrine Disease in Aged Horses
Aging horses may be at particular risk of endocrine disease. Two major equine endocrinopathies, pituitary pars intermedia dysfunction and equine metabolic syndrome, are commonly encountered in an aging population and may present with several recognizable signs, including laminitis. Investigation, treatment, and management of these diseases are discussed. Additionally, aging may be associated with development of rarer endocrinopathic problems, often associated with neoplasia, including diabetes mellitus and other confounders of glucose homeostasis, as well as thyroid, parathyroid, and adrenal diseases. Brief details of the ...
Source: Veterinary Clinics of North America: Equine Practice - July 20, 2016 Category: Veterinary Research Authors: Andy E. Durham Source Type: research

Clozapine users in Australia: their characteristics and experiences of care based on data from the 2010 National Survey of High Impact Psychosis.
CONCLUSIONS: Consistent with international evidence of clozapine underutilisation, a large number of participants with chronic illness and high symptom burden were not taking clozapine. The lower probabilities of current substance use and chronic pain among clozapine users warrant further study. PMID: 27426892 [PubMed - as supplied by publisher] (Source: Epidemiology and Psychiatric Sciences)
Source: Epidemiology and Psychiatric Sciences - July 20, 2016 Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research

Process evaluation of the Albany Physical Activity and Nutrition (APAN) program, a home-based intervention for metabolic syndrome and associated chronic disease risk in rural Australian adults.
Conclusions: Carefully planned recruitment will reduce the burden on resources and improve uptake. Understanding reasons for attrition such as family or personal barriers and health issues will assist practitioners to support participants overcome these barriers. Given participants' preference for printed resources, and the known effectiveness of these in combination with other strategies, investigating methods to encourage use of telephone and online support should be a priority.So what?: This process evaluation provided an overview of recruitment challenges and preferred intervention components. It is desirable that futu...
Source: Health Promotion Journal of Australia - July 20, 2016 Category: Global & Universal Tags: Health Promot J Austr Source Type: research

Co-morbidity in psoriasis: mechanisms and implications for treatment.
Authors: Lønnberg AS, Skov L Abstract INTRODUCTION: Psoriasis is a common, chronic, immune-mediated inflammatory disorder. The disease is associated with several co-morbidities including cardiovascular disease, metabolic syndrome, and psychiatric disorders. It is important to identify and treat these co-morbidities because they have a strongly negative effect on the overall health of patients with psoriasis. Unfortunately, these co-morbidities are often overlooked and/or left untreated. Therefore, the aim of this review is to discuss the mechanisms of how co-morbidities are associated with psoriasis as well as imp...
Source: Expert Review of Clinical Immunology - July 20, 2016 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Prevalence of metabolic syndrome in Iran: A 2011 update
ConclusionsOver the period 2007–11, the prevalence of metabolic syndrome has decreased slightly in Iran, although prevalence of increased FPG has increased significantly. One‐third of the Iranian adult population is diagnosed with metabolic syndrome. (Source: Journal of Diabetes)
Source: Journal of Diabetes - July 20, 2016 Category: Endocrinology Authors: Sina Noshad, Mehrshad Abbasi, Koorosh Etemad, Alipasha Meysamie, Mohsen Afarideh, Elias Khajeh, Fereshteh Asgari, Mostafa Mousavizadeh, Ali Rafei, Mohamadreza Neishaboury, Alireza Ghajar, Manouchehr Nakhjavani, Jalil Koohpayehzadeh, Alireza Esteghamati Tags: Original Article Source Type: research

High Variability of Insulin Sensitivity in Closely Related Obese Mouse Inbred Strains
This study identified 2 mouse lines with different impairments of insulin signalling. These lines resemble useful models for studying mechanisms leading to the pathophysiology of the metabolic syndrome, in particular insulin resistance.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 20, 2016 Category: Endocrinology Authors: Heise, S.Trost, J.Arends, D.Wirth, E. K.Schäfer, N.Köhrle, J.Schürmann, A.Brockmann, G. A. Tags: Article Source Type: research

Fitness Is Independently Associated with Central Hemodynamics in Metabolic Syndrome
Purpose: Fit individuals with metabolic syndrome (MetS) have lower mortality risk compared with less fit counterparts, despite the presence of obesity as a component of the syndrome. To understand the importance of fitness in treating this condition, we examined the association of fitness and fatness with central hemodynamic indices that are known independent predictors of cardiovascular events. Methods: Sixty-eight individuals with MetS participated in this cross-sectional study. Central hemodynamics is calculated from radial applanation tonometry and comprised aortic reservoir pressure, backward pressure wave (Pb), refl...
Source: Medicine and Science in Sports and Exercise - July 19, 2016 Category: Sports Medicine Tags: Applied Sciences Source Type: research

[Body composition and metabolic risk in small for gestational age children treated with growth hormone].
CONCLUSIONS: Treatment with GH produces changes in body composition, improving BMD and increasing the proportion of lean body mass with a reduction in fat mass. If these changes persisted into adulthood, they may cause a reduction in the metabolic and cardiovascular risk in this group of patients. PMID: 27423655 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - July 19, 2016 Category: Journals (General) Tags: Med Clin (Barc) Source Type: research

Associations between school meal-induced dietary changes and metabolic syndrome markers in 8–11-year-old Danish children
Conclusions DHA in whole-blood, an indicator of DHA and fish intake, seemed to be the main diet-related predictor of the beneficial effects of the school meals on MetS markers. Increased potato intake was associated with increased waist circumference, but this may not only be due to an increase in abdominal fat, as no association was seen with fat distribution. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - July 19, 2016 Category: Nutrition Source Type: research

Visceral adiposity syndrome
The association of anthropometric (waist circumference) and hemodynamic (blood pressure) changes with abnormalities in glucose and lipid metabolism has been motivation for a lot of discussions in the last 30 y... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - July 19, 2016 Category: Endocrinology Authors: Heno F. Lopes, Maria Lúcia Corrêa-Giannella, Fernanda M. Consolim-Colombo and Brent M. Egan Source Type: research

HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin.
CONCLUSIONS: These findings suggest that HMGB1 is a pro-inflammatory adipocytokine involved in WAT inflammation and insulin resistance in patients with obesity, which may contribute to the progression of metabolic syndrome, and that adiponectin protects against HMGB1-induced adipose tissue inflammation. PMID: 27430164 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - July 19, 2016 Category: Eating Disorders and Weight Management Authors: Shimizu T, Yamakuchi M, Biswas KK, Aryal B, Yamada S, Hashiguchi T, Maruyama I Tags: Obesity (Silver Spring) Source Type: research

Short-term isocaloric fructose restriction lowers apoC-III levels and yields less atherogenic lipoprotein profiles in children with obesity and metabolic syndrome
Dietary fructose may play a role in the pathogenesis of metabolic syndrome (MetS). In a recently published study of obese children with MetS, we showed that isocaloric fructose restriction reduced fasting triglyceride (TG) and LDL-cholesterol (LDL-C). In these ancillary analyses, we tested the hypothesis that these effects were also accompanied by improved quantitative and qualitative changes in LDL and HDL subclasses and their apolipoproteins; as well as change in VLDL, particularly apoC-III. (Source: Atherosclerosis)
Source: Atherosclerosis - July 19, 2016 Category: Cardiology Authors: Alejandro Gugliucci, Robert H. Lustig, Russell Caccavello, Ayca Erkin-Cakmak, Susan M. Noworolski, Viva W. Tai, Michael J. Wen, Kathleen Mulligan, Jean-Marc Schwarz Source Type: research

Interactions Between Host Genetics and Gut Microbiome in Diabetes and Metabolic Syndrome
Conclusions Understanding these complex interactions will help in the development of novel treatments for microbiome-related metabolic diseases. This article is part of a special issue on microbiota. (Source: Molecular Metabolism)
Source: Molecular Metabolism - July 19, 2016 Category: Endocrinology Source Type: research

The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis
Publication date: August 2016 Source:Journal of Functional Foods, Volume 25 Author(s): Boyeon Kim, Ha Rae Lim, Heeyoung Lee, Hyangki Lee, Wonku Kang, Eunyoung Kim The aim of the systematic review and meta-analysis was to evaluate the effects of conjugated linoleic acid (CLA) in metabolic syndrome (MS) patients. Randomized controlled trials (RCTs) conducted from inception to February 2015 were collected from seven databases. Among 1111 potentially relevant articles, nine RCTs (total 334 patients, 90% male) met inclusion criteria. A significant reduction in the CLA group in body weight and BMI (−0.51 kg [95% conf...
Source: Journal of Functional Foods - July 19, 2016 Category: Nutrition Source Type: research

Smartphone applications to aid weight loss and management: current perspectives
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - July 18, 2016 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

GSK-3 β promotes PA-induced apoptosis through changing β-arrestin 2 nucleus location in H9c2 cardiomyocytes
< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > Palmitic acid (PA), a type of saturated fatty acids, induces cardiovascular diseases by causing cardiomyocyte apoptosis with unclear mechanisms. Akt participates in PA-induced cardiomyocyte apoptosis. GSK-3 β is a substrate of Akt, we investigated its role in PA-induced apoptosis. We reveal that PA inhibits GSK-3β phosphorylation accompanied by inactivation of Akt in H9c2 cardiomyocytes. We also reveal that inhibition the activity of GSK-3β by its inhibitor LiCl or knockdown by siRNA significantly a ttenuates PA-induced cardiomyocyte apoptosis, ...
Source: Apoptosis - July 18, 2016 Category: Molecular Biology Source Type: research

GSK-3β promotes PA-induced apoptosis through changing β-arrestin 2 nucleus location in H9c2 cardiomyocytes
Abstract Palmitic acid (PA), a type of saturated fatty acids, induces cardiovascular diseases by causing cardiomyocyte apoptosis with unclear mechanisms. Akt participates in PA-induced cardiomyocyte apoptosis. GSK-3β is a substrate of Akt, we investigated its role in PA-induced apoptosis. We reveal that PA inhibits GSK-3β phosphorylation accompanied by inactivation of Akt in H9c2 cardiomyocytes. We also reveal that inhibition the activity of GSK-3β by its inhibitor LiCl or knockdown by siRNA significantly attenuates PA-induced cardiomyocyte apoptosis, this suggesting that GSK-3β plays a pro-apoptotic role. To ...
Source: Apoptosis - July 18, 2016 Category: Molecular Biology Source Type: research

Glucose homeostasis, insulin resistance and inflammatory biomarkers in patie ’nts with non-alcoholic fatty liver disease: Beneficial effects of supplementation with microalgae Chlorella vulgaris: A double- blind placebo- controlled randomized clinical trial
Chlorella vulgaris (C. vulgaris) is reported to improve dyslipidemia and hypertension ;however, its effect on inflammatory biomatkers and insulin resistance has not been noticed thus far. Non-alcoholic fatty liver disease (NAFLD) as a hepatic symptom of metabolic syndrome is strongly associated with insulin resistance and inflammation.Aim of the study: In the current interventional trial, we aimed to study the effects of C. vulgaris supplementation on glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with NAFLD. (Source: Clinical Nutrition)
Source: Clinical Nutrition - July 18, 2016 Category: Nutrition Authors: Mehrangiz Ebrahimi-Mameghani, Zahra Sadeghi, Mahdieh Abbasalizad Farhangi, Elnaz Vaghef-Mehrabany, Soodabeh Aliashrafi Tags: Randomized Control Trials Source Type: research

Relationship between dental caries and metabolic syndrome among 13  998 middle‐aged urban Chinese
ConclusionsDental caries were associated with MetS among middle‐aged Chinese in the present study. (Source: Journal of Diabetes)
Source: Journal of Diabetes - July 18, 2016 Category: Endocrinology Authors: Xia Cao, Dongliang Wang, Jiansong Zhou, Hong Yuan, Zhiheng Chen Tags: Original Article Source Type: research