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Salivary melatonin levels and sleep-wake rhythms in pregnant women with hypertensive and glucose metabolic disorders: A prospective analysis.
Authors: Shimada M, Seki H, Samejima M, Hayase M, Shirai F Abstract In preeclampsia and gestational diabetes, the sympathetic nerves are activated, leading to disrupted sleep. Melatonin, which transmits information to regulate the sleep-wake rhythm and other such biorhythms, has been implicated in insulin resistance, antioxidant behaviors, and metabolic syndrome. In addition, its reduced secretion increases the risk of hypertension and diabetes. The aim of this study was to elucidate the features of melatonin secretion, sleep quality, and sleep-wake rhythms in pregnant women with complications. Fifty-eight pregnant...
Source: BioScience Trends - February 10, 2016 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Fructose consumption induces hypomethylation of hepatic mitochondrial DNA in rats
We examined the effect of fructose-rich diets on mtDNA content, transcription, and epigenetic changes. Main methods Four-week-old male Sprague-Dawley rats were offered a 20% fructose solution for 14 weeks. We quantified mRNAs for hepatic mitochondrial genes and analyzed the mtDNA methylation (5-mC and 5-hmC) levels using ELISA kits. Key findings Histological analysis revealed non-alcoholic fatty liver disease (NAFLD) in fructose-fed rats. Hepatic mtDNA content and transcription were higher in fructose-fed rats than in the control group. Global hypomethylation of mtDNA was also observed in fructose-fed rats. Significance...
Source: Life Sciences - February 10, 2016 Category: Biology Source Type: research

Effects of High Protein Diets on Metabolic Syndrome Parameters
Publication date: Available online 8 February 2016 Source:Current Opinion in Food Science Author(s): Jennifer L. Wojcik, Harold M. Aukema, Peter Zahradka, Carla G. Taylor High protein diets are commonly promoted for the management of metabolic syndrome parameters. However, the current literature is complex with positive, detrimental and no effects being demonstrated. This conflicting evidence has prevented the development of concrete recommendations regarding the effectiveness and safety of high protein diets for managing metabolic syndrome. Furthermore, evidence that different dietary sources of protein have distinc...
Source: Current Opinion in Food Science - February 10, 2016 Category: Food Science Source Type: research

Association between lung capacity and abnormal glucose metabolism: findings from China and Australia
ConclusionsIn both the Australian and Chinese populations, the risk of type 2 diabetes and MS is lowest with a FEV1 of 2·65–2·76 l. This might be used in clinical practice in different countries as a prompt to screen for type 2 diabetes and MS in patients with obstructive lung disease and to ensure there was no abnormal glucose metabolism before the commencement of steroids if indicated. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 10, 2016 Category: Endocrinology Authors: Dahai Yu, Tao Chen, Rui Qin, Yamei Cai, Zhixin Jiang, Zhanzheng Zhao, David Simmons Tags: Original Article Source Type: research

The role of lipoxins in cardiometabolic physiology and disease
Cardiometabolic pathophysiology is increasing in prevalence as a result of the escalating obesity pandemic. The search for novel therapeutics is ongoing and the strong interrelationship between diabetes and cardiovascular disease places emphasis on the need for drugs that target both pathologies, without interlinking side effects. Impaired inflammatory resolution may be the common denominator driving metabolic syndrome, diabetes, and cardiovascular disease. An interesting therapeutic approach would therefore be to promote the inflammatory resolution to subvert cardiometabolic disease. Inflammatory resolution is regulated b...
Source: Cardiovascular Endocrinology - February 9, 2016 Category: Cardiology Tags: Reviews Source Type: research

Chapter 11: Metabolic Syndrome, Diet and Exercise
Polycystic ovary syndrome (PCOS) is associated with a range of metabolic complications including insulin resistance, obesity, dyslipidaemia, hypertension, obstructive sleep apnoea and non-alcoholic fatty liver disease. These compound risks result in a high prevalence of metabolic syndrome and possibly increased cardiovascular disease. As the cardiometabolic risk of PCOS is shared amongst the different diagnostic systems, all women with PCOS should undergo metabolic surveillance though the precise approach differs between guidelines. (Source: Best Practice and Research. Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research. Clinical Obstetrics and Gynaecology - February 9, 2016 Category: OBGYN Authors: Sunita MC. De Sousa, Robert J. Norman AO Source Type: research

Effects of Wearing Compression Stockings on the Physical Performance of T2DM Men with MetS
This study investigates the effects of wearing compression stockings on physical performance-related variables in type 2 diabetic men with metabolic syndrome (n=9, 57±12 years, BMI: 36±4 kg/m2). Participants served as their own controls in a randomized 3*3 crossover study wearing below-knee stockings with either compression (24 or 30 mmHg ankle pressure) or no compression. Venous pooling and lower limb oxygenation profiles were determined with near-infrared spectroscopy and arterial oxygen saturation was determined using a pulse oxymeter. Measurements were performed in the supine lying position, during standing, foll...
Source: International Journal of Sports Medicine - February 9, 2016 Category: Sports Medicine Authors: Brinkmann, C.Hermann, R.Rühl, E.Kerzel, H.Reinhardt, L.Grau, M.Latsch, J.Kohl-Bareis, M.Bloch, W.Brixius, K. Tags: Physiology & Biochemistry Source Type: research

Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response.
CONCLUSIONS: Our data suggest that dietary high fructose may potentiate chronic alcohol consumption-induced liver injury. The underlying mechanism might be due to the synergistic effect of dietary high fructose and alcohol on the activation of the TLR4 signaling pathway, which in turn leads to KC activation and phenotype switch toward M1 polarization. This study suggests that alcohol-fructose combination contributes to ALD progression. PMID: 26858005 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 9, 2016 Category: Addiction Authors: Song M, Chen T, Prough RA, Cave MC, McClain CJ Tags: Alcohol Clin Exp Res Source Type: research

The influence of BMI on the association between serum lycopene and the metabolic syndrome.
In conclusion, BMI appears to strongly influence the association between serum lycopene and the metabolic syndrome. PMID: 26857614 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - February 9, 2016 Category: Nutrition Authors: Han GM, Soliman GA, Meza JL, Islam KM, Watanabe-Galloway S Tags: Br J Nutr Source Type: research

A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats.
Abstract The prevalence of the metabolic syndrome components including abdominal obesity, dyslipidaemia and insulin resistance is increasing in both developed and developing countries. It is generally accepted that the development of these features is preceded by, or accompanied with, impaired mitochondrial function. The present study was designed to analyse the effects of a mitochondrial-targeted lipophilic ubiquinone (MitoQ) on muscle lipid profile modulation and mitochondrial function in obesogenic diet-fed rats. For this purpose, twenty-four young male Sprague-Dawley rats were divided into three groups and fed ...
Source: The British Journal of Nutrition - February 9, 2016 Category: Nutrition Authors: Coudray C, Fouret G, Lambert K, Ferreri C, Rieusset J, Blachnio-Zabielska A, Lecomte J, Ebabe Elle R, Badia E, Murphy MP, Feillet-Coudray C Tags: Br J Nutr Source Type: research

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease
Abstract Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome. Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened beverages are major risk factors for development of NAFLD. Today the most commonly consumed sugar is high fructose corn syrup. Hepatic lipids may be derived from dietary intake, esterification of plasma free fatty acids (FFA) or hepatic de novo lipogenesis (DNL). A central abnormality in NAFLD is enhanced DNL. Hepatic DNL is increased in individuals with NAFLD, while the contribution of dietary fat and plasma FFA to hepatic lipids is no...
Source: Digestive Diseases and Sciences - February 8, 2016 Category: Gastroenterology Source Type: research

Anthropometric Correlation with Metabolic syndrome in Sarajevo population.
Abstract Metabolic syndrome, described as one of the most common clustering metabolic risk factors in the world, combines minimum three of the following five risk factors: central obesity, elevated fasting glucose, lipid disorders, arterial hypertension and high serum triglycerides. International Diabetes Federation (IDF) in 2009 defined abdominal obesity as the waist circumference of ≥80 cm in women and ≥ 94 cm in men. The research goal of this study is to analyze the anthropometric risk factors for metabolic syndrome, their correlation and effects on metabolic indices related to metabolic syndrome in the anal...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 8, 2016 Category: Endocrinology Authors: Vanesa N, Svjetlana LZ, Jasmin Š Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Fecal microbiota transplantation: in perspective
There has been increasing interest in understanding the role of the human gut microbiome to elucidate the therapeutic potential of its manipulation. Fecal microbiota transplantation (FMT) is the administration of a solution of fecal matter from a donor into the intestinal tract of a recipient in order to directly change the recipient’s gut microbial composition and confer a health benefit. FMT has been used to successfully treat recurrent Clostridium difficile infection. There are preliminary indications to suggest that it may also carry therapeutic potential for other conditions such as inflammatory bowel disease, o...
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Gupta, S., Allen-Vercoe, E., Petrof, E. O. Tags: Reviews Source Type: research

Association between serum α-L-fucosidase and non-alcoholic fatty liver disease: Cross-sectional study.
CONCLUSION: AFU level is significantly associated with NAFLD, and elevated AFU level is an independent risk factor for NAFLD. PMID: 26855548 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2016 Category: Gastroenterology Authors: Lu ZY, Cen C, Shao Z, Chen XH, Xu CF, Li YM Tags: World J Gastroenterol Source Type: research

Prevalence of Metabolic Syndrome and its Related Risk Factors in the City of Oran, Algeria: the ISOR Study.
CONCLUSIONS: Metabolic syndrome, prevalent in the urban population of North Algeria, is associated with a high proportion of low HDL-cholesterol and abdominal obesity, especially among women. There is a need for prevention strategies involving promotion of physical activity for the whole population and screening for hypertension among men. PMID: 26843802 [PubMed - in process] (Source: Ethnicity and Disease)
Source: Ethnicity and Disease - February 6, 2016 Category: Global & Universal Tags: Ethn Dis Source Type: research

Associations of Sarcopenia and Sarcopenic Obesity With Metabolic Syndrome Considering Both Muscle Mass and Muscle Strength.
CONCLUSIONS: The associations of sarcopenia defined in terms of muscle mass and sarcopenic obesity with metabolic syndrome were statistically significant in both men and women. Therefore, sarcopenia and sarcopenic obesity must be considered as part of the community-based management of non-communicable diseases. PMID: 26841883 [PubMed - in process] (Source: Journal of Preventive Medicine and Public Health)
Source: Journal of Preventive Medicine and Public Health - February 6, 2016 Category: Global & Universal Tags: J Prev Med Public Health Source Type: research

The Role of Nutraceuticals for the Treatment of Non‐Alcoholic Fatty Liver Disease
In conclusion, there are insufficient data to either support or refute the use of nutraceuticals for subjects with NAFLD; further RTCs, with histological changes as outcome measure, are needed. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - February 6, 2016 Category: Drugs & Pharmacology Authors: Maria Del Ben, Licia Polimeni, Francesco Baratta, Daniele Pastori, Francesco Angelico Tags: Review ‐ Themed Issue Source Type: research

Management of immunosuppressant agents following liver transplantation: Less is more.
Authors: Ascha MS, Ascha ML, Hanouneh IA Abstract Immunosuppression in organ transplantation was revolutionary for its time, but technological and population changes cast new light on its use. First, metabolic syndrome (MS) is increasing as a public health issue, concomitantly increasing as an issue for post-orthotopic liver transplantation patients; yet the medications regularly used for immunosuppression contribute to dysfunctional metabolism. Current mainstay immunosuppression involves the use of calcineurin inhibitors; these are potent, but nonspecifically disrupt intracellular signaling in such a way as to exa...
Source: World Journal of Hepatology - February 5, 2016 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Sensing of nutrients and microbes in the gut
Purpose of review: Sensing of nutrients and microbes in the gut are fundamental processes necessary for life. This review aims to provide an overview of the basic background and new data on cellular nutrient, energy, and microbe sensors. Recent findings: The nutrient sensors 5’ adenosine monophosphate-activated protein kinase, activating transcription factor 4 and mechanistic target of rapamycin (mTOR) are critical in control of the cell cycle. Recent data demonstrate their role in metabolic syndrome, in cell growth, and as therapeutic targets. Regulation of mTOR by the amino acids is the subject of intense investigatio...
Source: Current Opinion in Gastroenterology - February 5, 2016 Category: Gastroenterology Tags: SMALL INTESTINE: Edited by Fergus Shanahan Source Type: research

In Search for a Common Pathway for Health Issues in Men - the Sign of a Holmesian Deduction.
Authors: Aoun F, Albisinni S, Chemaly AK, Zanaty M, Roumeguere T Abstract The evidence for the existence of a common pathway for health issues in men is presented in this review. Several epidemiological studies have shown that conditions like cardiovascular diseases (CVD), metabolic syndrome, diabetes, lower urinary tract symptom (LUTS), erectile dysfunction (ED), prostate cancer, hypogonadism, depression and suicide can be associated as risk factors for each other. Thus, the risk of CVD is significantly increased in men with metabolic syndrome, ED, hypogonadism, prostate cancer and/or LUTS. In addition, the above ...
Source: Asian Pacific Journal of Cancer Prevention - February 5, 2016 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Impaired stimulation of glucose transport in cardiac myocytes exposed to Very Low-Density Lipoproteins
In conclusions, VLDL-derived fatty acids impair stimulated glucose transport in cardiac myocytes by a mechanism that seems to be mediated by a fatty acid oxidation intermediate. Thus, in the clinical context of the metabolic syndrome high VLDL may contribute to enhancement of ischemic injury by reduction of metabolic stress-stimulated glucose uptake. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - February 5, 2016 Category: Nutrition Source Type: research

Approach to metabolic syndrome in childhood cancer survivors
JX Scott, MS Latha, R ArunaIndian Journal of Cancer 2015 52(2):169-172The combined effects of optimized chemotherapy, surgery, radiotherapy, stem cell transplantation regimens, and improved supportive care had drastically increased the survival rate of childhood cancer. Hence, the number of adult survivors of childhood cancer is on the raise and this subset of population is gaining more attention due to the late effects of their cancer therapy. There is growing evidence that pediatric cancer survivors are at a greater risk of developing metabolic syndrome (MS) or the MS component traits than the general population. There i...
Source: Indian Journal of Cancer - February 5, 2016 Category: Cancer & Oncology Authors: JX ScottMS LathaR Aruna Source Type: research

Nutritional status in survivors of childhood cancer: Experience from Tata Memorial Hospital, Mumbai
Conclusions: The prevalence of obesity/overweight is lower in our cohort when compared to Western literature. It remains to be clarified whether this reflects the underlying undernutrition in our country, or whether our cohort of survivors is indeed distinct from their Western counterparts. Comparison with age/sex-matched normal controls and baseline parameters would yield more meaningful results. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - February 5, 2016 Category: Cancer & Oncology Authors: M PrasadB AroraG ChinnaswamyT VoraG NarulaS BanavaliP Kurkure Source Type: research

The development, testing, and preliminary feasibility of an adaptable pediatric oncology nutrition algorithm for low-middle income countries
Conclusions: The prevalence of obesity/overweight is lower in our cohort when compared to Western literature. It remains to be clarified whether this reflects the underlying undernutrition in our country, or whether our cohort of survivors is indeed distinct from their Western counterparts. Comparison with age/sex-matched normal controls and baseline parameters would yield more meaningful results. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - February 5, 2016 Category: Cancer & Oncology Authors: CAK FlemingK VianiAJ MurphyTT MosbyB AroraJ SchoemanEJ Ladas Source Type: research

High triglyceride levels alter the correlation of Apolipoprotein B with low- and non-high-density lipoprotein cholesterol mostly in individuals with diabetes or metabolic syndrome
To assess the correlation of Apolipoprotein B (Apo-B) with low-density (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) in untreated individuals attending a lipid clinic. (Source: Atherosclerosis)
Source: Atherosclerosis - February 5, 2016 Category: Cardiology Authors: Fotios Barkas, Moses Elisaf, Evangelos Liberopoulos, Angelos Liontos, Evangelos C. Rizos Source Type: research

Computerized tomography measured liver fat is associated with low levels of N-terminal pro-brain natriuretic protein (NT-proBNP). Multi-Ethnic Study of Atherosclerosis.
N-terminal pro B-type natriuretic peptide (NT-proBNP) is inversely associated with diabetes mellitus, obesity and metabolic syndrome. We aim to characterize the association between NT-proBNP and nonalcoholic fatty liver disease (NAFLD), a condition strongly associated with metabolic syndrome. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 5, 2016 Category: Biomedical Science Authors: Otto A. Sanchez, Lazo-Elizondo Mariana, Zeb Irfan, Russell P. Tracy, Ryan Bradley, Daniel A. Duprez, Hossein Bahrami, Carmen A. Peralta, Lori B. Daniels, João A. Lima, Alan Maisel, David R. Jacobs, M.J. Budoff Source Type: research

Helicobacter pylori and metabolic syndrome.
PMID: 26853791 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - February 5, 2016 Category: Gastroenterology Authors: Köklü H, Köklü S, Çınar H Tags: Turk J Gastroenterol Source Type: research

Investigation of the Relationship Between Chronic Stress and Insulin Resistance in a Chinese Population.
CONCLUSIONS: These findings showed that chronic stress was associated with insulin resistance and may contribute to the development of insulin resistance. PMID: 26830350 [PubMed - as supplied by publisher] (Source: Journal of Epidemiology)
Source: Journal of Epidemiology - February 4, 2016 Category: Epidemiology Tags: J Epidemiol Source Type: research

Higher Body Mass Index and Increased Prevalence of Paranasal Sinus Disease.
CONCLUSIONS: The present study suggests that patients with higher BMI are more likely to have paranasal sinus disease. PMID: 26830349 [PubMed - as supplied by publisher] (Source: Journal of Epidemiology)
Source: Journal of Epidemiology - February 4, 2016 Category: Epidemiology Tags: J Epidemiol Source Type: research

Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice.
In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model. PMID: 26840707 [PubMed - as supplied by publisher] (Source: Brazilian Journal of Medical and Biological Research)
Source: Brazilian Journal of Medical and Biological Research - February 4, 2016 Category: Research Tags: Braz J Med Biol Res Source Type: research

Aglucidic Enteral Nutritional Therapy “AENT”: Impact on psoriasis and fibromyalgia, insulin-sensitive diseases
Psoriasis and fibromyalgia are chronic inflammatory diseases. Psoriatic and fibromyalgic patients have increased odds of metabolic syndrome; there is a correlation between psoriasis, fibromyalgia and insulin resistance supported by the improvement of the diseases after dietary restriction with weight decrease. (Source: Nutrition)
Source: Nutrition - February 4, 2016 Category: Nutrition Authors: G. Castaldo, G. Galdo, P. Molettieri, A. Vitale, L. Monaco, F. Rotondi Aufiero Tags: Selected abstract Source Type: research

Association among insulin-resistance indexes and C-reactive protein in overweight and obese men
The C-reactive protein (CRP) is a hepatic protein and non-specific marker of acute phase inflammation. It has been linked directly or indirectly, to hypertension, cardiovascular diseases, type II diabetes and metabolic syndrome. Recently this marker has been positively associated with an increase of the body fat percentage, particularly of the abdominal portion. The aim of this study is to evaluate the relationship among the insulin-resistance indexes and the CRP in overweight and obese men. (Source: Nutrition)
Source: Nutrition - February 4, 2016 Category: Nutrition Authors: S. Perna, D. Guido, M.A. Faliva, V. Infantino, G. Peroni, M. Naso, M. Rondanelli Tags: Selected abstract Source Type: research

Relationship between desacilated ghrelin and metabolic syndrome factors in overweight and obese italian adults: A cross sectional study
Ghrelin is a hormone which influences eating habits, the amount of food ingested and the body’s energy balance. This cross sectional study aimed to investigate the relationship between hormone desacilated ghrelin and metabolic syndrome factors such as insulin, HDL cholesterol, triglycerides, glycemia, waist circumference, blood pressure. (Source: Nutrition)
Source: Nutrition - February 4, 2016 Category: Nutrition Authors: S. Perna, D. Guido, A. Carcagnì, A. Isu, M.A. Faliva, G. Peroni, M. Rondanelli Tags: Selected abstract Source Type: research

Medication Use and Metabolic Syndrome Among Overweight/Obese Patients With and Without Binge-Eating Disorder in a Primary Care Sample.
CONCLUSIONS: Despite higher BMI, pulse, and waist circumference, the current sample of BED patients in primary care did not present with poorer metabolic health than NBO patients. PMID: 26835176 [PubMed] (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - February 4, 2016 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
Publication date: Available online 3 February 2016 Source:Life Sciences Author(s): Vibha Rani, Gagan Deep, Rakesh K. Singh, Komaraiah Palle, Umesh C.S. Yadav Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes and cardiovascular complications together constitute metabolic syndrome. The pathogenesis of metabolic syndrome involves multitude of factors. A number of studies however indicate, with some conformity, that oxidative stress along with chronic inflammatory condition pave the way for the development of metabolic diseases. Oxidative stress, a state of lost balance between t...
Source: Life Sciences - February 4, 2016 Category: Biology Source Type: research

Lifestyle modification and weight reduction among low-income patients with the metabolic syndrome: the CHARMS randomized controlled trial
Abstract Although weight is an important intervention target among patients with metabolic syndrome, few trials have recruited low-income minority populations. The Community Health and Risk-reduction for Metabolic Syndrome randomized controlled trial aimed to examine the effects of a lifestyle intervention on weight and metabolic syndrome components among low-income minority adults. We randomized 120 adults with metabolic syndrome to standard medical care (N = 60) or a lifestyle intervention (N = 60). Using an intent-to-treat approach, we found significant intervention effects on weight [B = −0.452; SE =...
Source: Journal of Behavioral Medicine - February 4, 2016 Category: Psychiatry Source Type: research

Obesity and related consequences to ageing
Abstract Obesity has become a major public health problem. Given the current increase in life expectancy, the prevalence of obesity also raises steadily among older age groups. The increase in life expectancy is often accompanied with additional years of susceptibility to chronic ill health associated with obesity in the elderly. Both obesity and ageing are conditions leading to serious health problems and increased risk for disease and death. Ageing is associated with an increase in abdominal obesity, a major contributor to insulin resistance and the metabolic syndrome. Obesity in the elderly is thus a serious c...
Source: AGE - February 4, 2016 Category: Geriatrics Source Type: research

Adverse events in faecal microbiota transplant: a review of the literature
Conclusion The vast majority of adverse events of FMT appear to be mild, self-limiting and gastrointestinal in nature. In some cases, a credible association was not established due to the lack of controlled data. There is a need for standardized, randomized controlled trials to qualify and quantify the risks associated with FMT. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - February 4, 2016 Category: Infectious Diseases Source Type: research

Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study
To test in multicenter setting if patients affected of metabolic syndrome (MetS) and initial widespread high grade prostatic intraepithelial neoplasia (wHGPIN) diagnosis are at higher risk of prostate cancer (... (Source: BMC Cancer)
Source: BMC Cancer - February 4, 2016 Category: Cancer & Oncology Authors: Antonio Cicione, Cosimo De Nunzio, Andrea Tubaro, Francesco Cantiello, Stefano Manno, Carlos Oliveira, Estevao Lima and Rocco Damiano Source Type: research

Tooth loss and metabolic syndrome in middle-aged Japanese adults.
CONCLUSIONS: Metabolic syndrome was associated with the incidence of tooth loss among middle-aged adults. This article is protected by copyright. All rights reserved. PMID: 26847391 [PubMed - as supplied by publisher] (Source: Journal of Clinical Periodontology)
Source: Journal of Clinical Periodontology - February 4, 2016 Category: Dentistry Authors: Furuta M, Liu A, Shinagawa T, Takeuchi K, Takeshita T, Shimazaki Y, Yamashita Y Tags: J Clin Periodontol Source Type: research

Role of antigen presentation in the production of pro-inflammatory cytokines in obese adipose tissue.
Abstract Type II diabetes regroups different physiological anomalies that ultimately lead to low-grade chronic inflammation, insulin resistance and loss of pancreatic β-cells. Obesity is one of the best examples of such a condition that can develop into Metabolic Syndrome, causing serious health problems of great socio-economic consequences. The pathological outcome of obesity has a genetic basis and depends on the delicate balance between pro- and anti-inflammatory effectors of the immune system. The causal link between obesity and inflammation is well established. While innate immunity plays a key role in the de...
Source: Cytokine - February 4, 2016 Category: Molecular Biology Authors: Majdoubi A, Kishta OA, Thibodeau J Tags: Cytokine Source Type: research

Association between serum 25-hydroxyvitamin D concentrations and prevalence of metabolic syndrome
Conclusions We found no significant difference in serum 25OHD concentrations between individuals with or without MetS and no significant linear relationship between serum 25OHD and several CVD risk factors. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 3, 2016 Category: Biomedical Science Source Type: research

Sodium-Sensitive Elevation in Blood Pressure is ENaC Independent in Diet-Induced Obesity and Insulin Resistance.
Abstract The majority of patients with obesity, insulin resistance, and the metabolic syndrome have hypertension, but the mechanisms of hypertension are poorly understood. In these patients, impaired sodium excretion is critical for the genesis of sodium-sensitive hypertension, and prior studies have proposed a role for the epithelial sodium channel (ENaC) in this syndrome. We characterized high fat-fed mice as a model in which to study the contribution of ENaC-mediated sodium reabsorption in obesity and insulin resistance. High fat-fed mice demonstrated impaired sodium excretion and elevated blood pressure that wa...
Source: Am J Physiol Renal P... - February 3, 2016 Category: Urology & Nephrology Authors: Nizar JM, Dong W, McClellan RB, Labarca M, Zhou Y, Wong J, Goens DG, Zhao M, Velarde N, Bernstein D, Pellizzon M, Satlin LM, Bhalla V Tags: Am J Physiol Renal Physiol Source Type: research

Role of body composition and metabolic profile in Barrett’s oesophagus and progression to cancer
Background and aims: The aim of this study was to evaluate the risk for Barrett’s oesophagus (BE) on the basis of body composition, metabolic pathways, adipokines and metabolic syndrome (MS), as well as their role in cancer progression. Methods: In patients with and without BE at gastroscopy, data on MS, BMI, waist/hip ratio for abdominal obesity (AO) and body fat percentage by bioimpedance were obtained. Fasting plasma glucose, insulin, HbA1c, lipid, serum adiponectin and leptin levels were measured. The homoeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. Histological findings for BE were c...
Source: European Journal of Gastroenterology and Hepatology - February 2, 2016 Category: Gastroenterology Tags: Original Articles: Gastro-oesophageal Disorders Source Type: research

Activation of the dsRNA-Activated Protein Kinase PKR in Mitochondrial Dysfunction and Inflammatory Stress in Metabolic Syndrome.
CONCLUSION: This review highlights recent findings in PKR-mediated metaflammation and its association with the onset of metabolic syndrome in both human and animal models, with a focus on the molecular and biochemical pathways that underlie the progression of obesity, insulin resistance, and type-2 diabetes. PMID: 26831644 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 2, 2016 Category: Drugs & Pharmacology Authors: Sud N, Rutledge AC, Pan K, Su Q Tags: Curr Pharm Des Source Type: research

Metabolic syndrome predicts plaque rupture in patients with acute myocardial infarction. An optical coherence study
The metabolic syndrome (MS) is conceptualized as a clustering of risk factors-including insulin resistance, dyslipidemia, central adiposity, and elevated blood pressure (BP)-that increase the risk for cardiovascular disease and type 2 diabetes mellitus (DM) [1]. Metabolic syndrome is known to be a low-grade systemic inflammatory condition with its origins in the perinatal period and childhood, while recent evidence suggests that markers of systemic inflammation may be included in the definition of the syndrome and play some role in its pathogenesis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 2, 2016 Category: Cardiology Authors: Andreas Synetos, Angelos Papanikolaou, Konstantinos Toutouzas, George Georgiopoulos, Antonis Karanasos, Maria Drakopoulou, George Latsios, Spyridon Papaioannou, Eleftherios Tsiamis, Dimitris Tousoulis Source Type: research

The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis
The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity, and the metabolic syndrome has sparked interest in stem cell-like liver progenitor cells (LPCs) as potential candidates for cell therapy and tissue engineering, as an alternative approach to whole organ transplantation. However, LPCs always proliferate in chronic liver diseases with a predisposition to cancer; they have been suggested to play major roles in driving fibrosis, disease progression, and may even represent tumor-initiating cells. Hence, a greater unde...
Source: AJP: Gastrointestinal and Liver Physiology - February 2, 2016 Category: Gastroenterology Authors: Köhn-Gaone, J., Gogoi-Tiwari, J., Ramm, G. A., Olynyk, J. K., Tirnitz-Parker, J. E. E. Tags: REVIEWS Source Type: research

Cardiorespiratory Fitness and Metabolic Syndrome in Postmenopausal African-American Women
We examined the association of cardiorespiratory fitness with metabolic syndrome in overweight/obese postmenopausal African-American women. Pooled baseline data on 170 African-American women from 2 exercise trials were examined. Metabolic syndrome was defined as at least 3 of the following: abdominal obesity, glucose intolerance, hypertension, low high-density lipoprotein cholesterol (HDL-C), and high triglycerides. Cardiorespiratory fitness (VO2peak) was determined using the Bruce treadmill protocol and categorized as: Very Low (VLCRF<18 mL·kg−1 min−1), Low (LCRF=18.0–220–22–22.0 mL·kg−1 min−1), a...
Source: International Journal of Sports Medicine - February 2, 2016 Category: Sports Medicine Authors: Adams-Campbell, L. L.Dash, C.Kim, B. H.Hicks, J.Makambi, K.Hagberg, J. Tags: Physiology & Biochemistry Source Type: research

Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome
Shear-dependent inhibition of lymphatic thoracic duct (TD) contractility is principally mediated by nitric oxide (NO). Endothelial dysfunction and poor NO bioavailability are hallmarks of vasculature dysfunction in states of insulin resistance and metabolic syndrome (MetSyn). We tested the hypothesis that flow-dependent regulation of lymphatic contractility is impaired under conditions of MetSyn. We utilized a 7-wk high-fructose-fed male Sprague-Dawley rat model of MetSyn and determined the stretch- and flow-dependent contractile responses in an isobaric ex vivo TD preparation. TD diameters were tracked and contractile par...
Source: AJP: Heart and Circulatory Physiology - February 1, 2016 Category: Cardiology Authors: Zawieja, S. D., Gasheva, O., Zawieja, D. C., Muthuchamy, M. Tags: VASCULAR BIOLOGY AND MICROCIRCULATION Source Type: research

Maternal circulating levels of some metabolic syndrome biomarkers in gestational diabetes mellitus
Abstract The aims of the present study were to explore serum levels of lipid profile, atherogenic indexes LDL-C/HDL-C, TG/HDL-C, and TC/HDL-C, bilirubin, adiponectin, pseudocholinesterase, activities of gamma-glutamyltransferase (GGT), adenosine deaminase (ADA), and α-amylase, insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR) formula, and assessment of correlations between them in gestational diabetes mellitus (GDM) compared with normal pregnancy. A cross-sectional study was designed. The patients consisted of 30 women with GDM. The normal group consisted of 30 healthy pregnan...
Source: Endocrine - February 1, 2016 Category: Endocrinology Source Type: research