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Hypoglycemic and antihyperglycemic effects of phytopreparations and limonoids from Swietenia humilis
Publication date: Available online 19 December 2014 Source:Phytochemistry Author(s): Berenice Ovalle-Magallanes , Omar N. Medina-Campos , José Pedraza-Chaverri , Rachel Mata An aqueous extract from the seeds of Swietenia humilis (31.6–100mg/kg bw) lowered (p < 0.05) blood glucose levels in normal and nicotinamide–streptozotocin (NA–STZ)-induced hyperglycemic mice. Furthermore, when administered to fructose-fed rats with metabolic syndrome, the decoction showed significant antihyperglycemic, hypoglycemic and hypolipidemic effects, as well as an augmentation of hepatic glycogen. Limonoids 2-hydroxy-destigloyl...
Source: Phytochemistry - December 20, 2014 Category: Chemistry Source Type: research

3: Effect of treatment of mild gestational diabetes on long-term maternal outcomes
To evaluate if identification and treatment of women with mild gestational diabetes affects subsequent risk of maternal diabetes, metabolic syndrome, BMI, or anthropometric measurements. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Brian Casey Tags: Oral plenary session I Source Type: research

33: Adverse pregnancy outcomes and subsequent metabolic syndrome
To evaluate whether preeclampsia/gestational hypertension (PE/GHTN) and preterm birth (PTB) are associated with maternal metabolic syndrome (MetSyn) later in life. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Madeline Rice Tags: Oral concurrent session 3 Source Type: research

45: Effect of high fat diet on metabolic programming in offspring born to hypertensive mother
We previously reported that mice born to hypertensive mother, lacking endothelial nitric oxide synthase (NOS3), are hypertensive. We hypothesized that offspring born to hypertensive mother, and placed on high fat diet (HFD) will undergo altered developmental programming, making them at increased risk of developing metabolic syndrome. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Monica Longo, Jerrie Refuerzo, Lovepreet Mann, Mateo Leon, Hind Moussa, Baha Sibai, Sean Blackwell Tags: Oral concurrent session 4 Source Type: research

68: Multigenerational heritable metabolome changes are modifiable by maternal dietary supplementation in an IUGR rat model
We have previously demonstrated that metabolic syndrome (MetS) exhibits multigenerational epigenetic inheritance in IUGR rats. Moreover, supplementation of essential nutrients (ENS) along the 1-carbon pathway and necessary for DNA methylation results in abrogation of adult MetS in the F2 generation. Here, we hypothesized that alterations in the metabolome would manifest prior to the onset of adult MetS, and could thus serve as potential biomarkers for later in life disease. We therefore sought to broadly profile blood metabolites in the F2 generation of our IUGR model at the time of weaning. (Source: American Journal of Ob...
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Maxim Seferovic, Derrick Chu, Danielle Goodspeed, Laura Krannich, James Cox, Kjersti Aagaard Tags: Oral concurrent session 6 Source Type: research

299: Alterations in thyroid regulation in a rat model of multigenerational IUGR and adult metabolic syndrome
We have recently shown in a multigenerational IUGR model that the F2 generation exhibits characteristics of MetS, including increased central fat mass, dyslipidemia, and diabetes. Although the heritability of IUGR was not altered at birth, adult MetS was abrogated by 1-carbon pathway essential nutrient supplementation (ENS) in the F1 and F2 generation. Based on ours and others prior findings relating placental regulation of thyroid hormone to aberrant fetal programming, we hypothesized that ENS-mediated amelioration of the adult MetS phenotype in the F2 generation may involve restoration of altered thyroid hormone. (Source...
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Danielle Goodspeed, Maxim Seferovic, Melissa Suter, D. Ware Branch, Robert Lane, Kjersti Aagaard Tags: Poster session II Source Type: research

563: Maternal metabolic syndrome 5-10 years after delivery in women with abnormal 1 hour glucose screening
To determine if maternal glucose intolerance below the conventional gestational diabetes mellitus (GDM) cut points is related to an increased risk of maternal metabolic syndrome (MMS) 5-10 years after delivery and if maternal factors at or before delivery can predict MMS. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Uma Reddy Tags: Poster session III Source Type: research

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome [Gene-nutrient interactions]
Conclusion: A healthy Nordic diet reduces inflammatory gene expression in SAT compared with a control diet independently of body weight change in individuals with features of the metabolic syndrome. The study was registered at clinicaltrials.gov as NCT00992641. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - December 19, 2014 Category: Nutrition Authors: Kolehmainen, M., Ulven, S. M., Paananen, J., de Mello, V., Schwab, U., Carlberg, C., Myhrstad, M., Pihlajamaki, J., Dungner, E., Sjolin, E., Gunnarsdottir, I., Cloetens, L., Landin-Olsson, M., Akesson, B., Rosqvist, F., Hukkanen, J., Herzig, K.-H., Dragst Tags: Gene-nutrient interactions Source Type: research

Nontargeted Metabolite Profiling Discriminates Diet-Specific Biomarkers for Consumption of Whole Grains, Fatty Fish, and Bilberries in a Randomized Controlled Trial [Genomics, Proteomics, and Metabolomics]
Conclusions: Novel biomarkers of the intake of health-beneficial food items included in the Nordic diet were identified by the metabolite profiling of fasting plasma and confirmed by the correlation analyses with dietary records. The one with the most potential was CMPF, which was shown to be a highly specific biomarker for fatty fish intake. This trial was registered at clinicaltrials.gov as NCT00573781. (Source: Journal of Nutrition)
Source: Journal of Nutrition - December 19, 2014 Category: Nutrition Authors: Hanhineva, K., Lankinen, M. A., Pedret, A., Schwab, U., Kolehmainen, M., Paananen, J., de Mello, V., Sola, R., Lehtonen, M., Poutanen, K., Uusitupa, M., Mykkanen, H. Tags: Genomics, Proteomics, and Metabolomics Source Type: research

Plasma calprotectin and its association with cardiovascular disease manifestations, obesity and the metabolic syndrome in type 2 diabetes mellitus patients
Conclusion: T2DM patients had higher concentrations of plasma calprotectin, which were associated with obesity, MetS status, autonomic neuropathy, PAD, and MI. However, plasma calprotectin was not an independent predictor of CVD, MI, autonomic neuropathy or PAD.Trial registration number: at http://www.clinicaltrial.gov: NCT00298844 (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - December 19, 2014 Category: Cardiology Authors: Lise PedersenMads NyboMikael PoulsenJan HenriksenJordi DahlLars Rasmussen Source Type: research

Serum glucose and risk of cancer: a meta-analysis
Conclusion: A positive association between serum glucose and risk of cancer was found. The underlying biological mechanisms remain to be elucidated but our subgroup analyses suggest that the insulin- IGF-1 axis does not fully explain the association. These findings are of public health importance as measures to reduce serum glucose via lifestyle and dietary changes could be implemented in the context of cancer mortality. (Source: BMC Cancer)
Source: BMC Cancer - December 19, 2014 Category: Cancer & Oncology Authors: Danielle CrawleyLars HolmbergJennifer MelvinMassimo LodaSimon ChowdhurySarah RudmanMieke Van Hemelrijck Source Type: research

Histone Deacetylase 8 Is a Novel Chromatin Modulator in NAFLD-Associated Hepatocarcinogenesis
This study aimed to identify and validate novel chromatin modulators in NAFLD-associated hepatocarcinogenesis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2014 Category: Gastroenterology Authors: Yuan Tian, Ka F. To, Paul B.S. Lai, Yue S. Cheung, Vincent W.S. Wong, Henry L.Y. Chan, Alfred S.L. Cheng Tags: International digestive disease forum, Hong Kong, 2014 Source Type: research

Impact of metabolic syndrome on response to medical treatment of benign prostatic hyperplasia.
CONCLUSIONS: The results of the present study showed that MetS can negatively affect the response to medical treatment of BPH. Therefore, it is necessary to consider MetS in selecting patients with BPH for drug therapy. PMID: 25512816 [PubMed - in process] (Source: Korean Journal of Urology)
Source: Korean Journal of Urology - December 18, 2014 Category: Urology & Nephrology Tags: Korean J Urol Source Type: research

Dissecting the Association Between Metabolic Syndrome and Prostate Cancer Risk: Analysis of a Large Clinical Cohort
Conclusions Although the individual MetS components are not independently associated with PCa outcomes, MetS is significantly associated with higher odds of PCa diagnosis, CSPC, and I-HGPC. There is a biologic gradient between the number of MetS components and the risk of PCa, as well as cancer grade. Patient summary Metabolic syndrome is a collection of metabolic abnormalities that increases one's risk for heart disease. Our study shows that an increasing degree of metabolic abnormality is also associated with an increased risk of diagnosis of overall and aggressive prostate cancer. In men undergoing prostate biopsy, met...
Source: European Urology - December 18, 2014 Category: Urology & Nephrology Source Type: research

Metabolic Syndrome as a Marker for Prostate Cancer: Still a Work in Progress
Publication date: January 2015 Source:European Urology, Volume 67, Issue 1 Author(s): Andrea Gallina , Alessandro Nini , Francesco Montorsi , Alberto Briganti (Source: European Urology)
Source: European Urology - December 18, 2014 Category: Urology & Nephrology Source Type: research

Reply from Authors re: Andrea Gallina, Alessandro Nini, Francesco Montorsi, Alberto Briganti. Metabolic Syndrome as a Marker for Prostate Cancer: Still a Work in Progress. Eur Urol 2015;67:71–2
Publication date: January 2015 Source:European Urology, Volume 67, Issue 1 Author(s): Bimal Bhindi , Neil E. Fleshner (Source: European Urology)
Source: European Urology - December 18, 2014 Category: Urology & Nephrology Source Type: research

Apelin rs2235306 polymorphism is not related to metabolic syndrome in Egyptian women
Conclusion Apelin rs2235306 polymorphism is not associated with the incidence of metabolic syndrome in the studied population. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - December 18, 2014 Category: Genetics & Stem Cells Source Type: research

Replication of risk variants for psoriasis in a Southern European case‐control study: correlation with clinical subphenotypes
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - December 18, 2014 Category: Dermatology Authors: S. Masouri, I. Stefanaki, K.P. Kypreou, E. Kodela, G. Bethimoutis, G. Ntritsos, E. Evangelou, A.J. Stratigos, C. Antoniou Tags: Research Letter Source Type: research

The prevalence of NAFLD and NASH among patients with psoriasis in a tertiary care dermatology and rheumatology clinic
ConclusionsNon‐alcoholic fatty liver disease is very common among our cohort of patients with psoriasis, occurring in roughly 47% of patients. The more progressive form of the disease, NASH, is found in approximately one in five patients. Health care providers should be mindful of this association given the high prevalence of both NAFLD and NASH in this cohort of patients. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - December 18, 2014 Category: Drugs & Pharmacology Authors: K. K. Roberts, A. E. Cochet, P. B. Lamb, P. J. Brown, D. F. Battafarano, E. M. Brunt, S. A. Harrison Tags: Original Article Source Type: research

11{beta}-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue
Long-term glucocorticoid exposure increases the risk for developing type 2 diabetes. Prereceptor activation of glucocorticoid availability in target tissue by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) coupled with hexose-6-phosphate dehydrogenase (H6PDH) is an important mediator of the metabolic syndrome. We explored whether the tissue-specific modulation of 11β-HSD1 and H6PDH in adipose tissue mediates glucocorticoid-induced insulin resistance and lipolysis and analyzed the effects of 11β-HSD1 inhibition on the key lipid metabolism genes and insulin-signaling cascade. We observed that corticos...
Source: AJP: Endocrinology and Metabolism - December 18, 2014 Category: Endocrinology Authors: Wang, Y., Yan, C., Liu, L., Wang, W., Du, H., Fan, W., Lutfy, K., Jiang, M., Friedman, T. C., Liu, Y. Tags: Articles Source Type: research

PEDF-induced alteration of metabolism leading to insulin resistance
Publication date: 5 February 2015 Source:Molecular and Cellular Endocrinology, Volume 401 Author(s): Revathy Carnagarin , Arunasalam M. Dharmarajan , Crispin R. Dass Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in insulin resistance. Insulin resistance is the central pathogenesis of metabolic disorders such as obesity, type 2 diabetes mellitus, polycystic ovarian disease, and metabolic syndrome, and PEDF is associated with them. The current evidence sug...
Source: Molecular and Cellular Endocrinology - December 18, 2014 Category: Endocrinology Source Type: research

Cardiovascular disease risk factors and ventilatory function: a cross-sectional study in young adults
Conclusion: Many CVD risk factors are associated with poorer ventilatory function in young adults. Endeavours to understand better causality issues of such associations are warranted. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 18, 2014 Category: Respiratory Medicine Authors: Vanessa Garcia-LarsenPatricia BustosHugo AmigoJames PottsRoberto Rona Source Type: research

Vagus nerve contributes to metabolic syndrome in high‐fat diet‐fed young and adult rats
New Findings What is the central question of this study? Differentnerve contributes periods of life are known for their differential sensitivity to interventions, and increased parasympathetic activity affects the development and maintenance of obesity. Thus, we evaluated the involvement of the vagus nerve by performing a vagotomy in young or adult rats that were offered an obesogenic high‐fat diet. What is the main finding and its importance? Although the accumulation of adipose tissue decreased in both younger and older groups, the younger rats showed a greater response to the effects of vagotomy in general. In addi...
Source: Experimental Physiology - December 18, 2014 Category: Physiology Authors: Luiz F. Barella, Rosiane A. Miranda, Claudinéia C. S. Franco, Vander S. Alves, Ananda Malta, Tatiane A. S. Ribeiro, Clarice Gravena, Paulo C. F. Mathias, Júlio C. de Oliveira Tags: Research Paper Source Type: research

Alterations of Cortisol Homeostasis May Link Changes of the Sociocultural Environment to an Increased Diabetes and Metabolic Risk in Developing Countries: A Prospective Diagnostic Study Performed in Cooperation With the Ovahimba People of the Kunene Region/Northwestern Namibia.
Conclusions: Urbanization of the Ovahimba people is associated with an increasing prevalence of disorders of glucose metabolism and other unfavorable metabolic parameters. Besides changes of lifestyle, this may be attributed to an increased cortisol exposure of the Ovahimba people living in an urban environment. PMID: 25522263 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 18, 2014 Category: Endocrinology Authors: Kann PH, Münzel M, Hadji P, Daniel H, Flache S, Nyarango P, Wilhelm A Tags: J Clin Endocrinol Metab Source Type: research

Rapid Screening of Psychological Well-Being of Patients with Chronic Illness: Reliability and Validity Test on WHO-5 and PHQ-9 Scales.
This study intended to test the reliability and validity of two simple psychological screening scales, the World Health Organization Well-being Index (WHO-5) and the 9-item Patient Health Questionnaire (PHQ-9), in patients with chronic illness in Taiwan and to understand the psychological well-being of patients with chronic illness (e.g., metabolic syndrome) in Taiwan and the incidences of psychological problems that follow. The research design of this study was a descriptive cross-sectional study. The sample comprised 310 patients with metabolic syndrome (MS), aged 20 years or more, from the outpatient clinic of a municip...
Source: Depression Research and Treatment - December 17, 2014 Category: Psychiatry Tags: Depress Res Treat Source Type: research

Sleep Complaints and Metabolic Syndrome in an Elderly Population: The Three-City Study.
CONCLUSION: We report significant independent associations between frequent sleep complaints (EDS and to a lesser extent DMS) and MetS in the elderly with potential implications in terms of management and cardiovascular prevention in general geriatric practice. Prospective studies are required to clarify the direction of the association between sleep complaints and MetS. PMID: 25499672 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - December 17, 2014 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

The association between retinal microvascular changes, metabolic risk factors, and liver histology in pediatric patients with non-alcoholic fatty liver disease (NAFLD)
Conclusions We found an association between metabolic parameters and nocturnal blood pressure on the retinal microvasculature among the obese children with NAFLD. Furthermore, for the first time, we report the positive relationship between hepatic fibrosis in pediatric NAFLD patients and the degree of retinopathy signs. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 17, 2014 Category: Gastroenterology Source Type: research

New research developments and insights from Metabolism
In a field of great importance to daily life and clinical care, metabolic-related research covers a wealth of information and knowledge. This broad field encompasses a number of physical states that are increasingly critical to study, including obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Additionally, the impacts of diet, nutrition, and exercise on these physical states are an area of ever-important and expanding research. With the latest advances in metabolic research, much knowledge has been gained. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 17, 2014 Category: Biomedical Science Authors: Olivia M. Farr, Michelle Camp, Christos S. Mantzoros Source Type: research

Serum prolidase activity is associated with non-diabetic metabolic syndrome
Conclusion: Prolidase activity may have a role in the pathogenesis of metabolic syndrome. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - December 17, 2014 Category: Endocrinology Authors: Suzan TaburElif O¿uzMehmet ErenHakan KorkmazEsen Sava¿Nurten AksoyTevfik Sabuncu Source Type: research

Depressive symptoms, cognitive impairment, and metabolic syndrome in community‐dwelling elderly in Southern Taiwan
ConclusionsDepressive symptoms and metabolic syndrome are independently associated with cognitive impairment among community‐dwelling elderly. (Source: Psychogeriatrics)
Source: Psychogeriatrics - December 17, 2014 Category: Geriatrics Authors: Ting‐Ting Chang, For‐Wey Lung, Yung‐Chieh Yen Tags: Original Article Source Type: research

Using Non-Invasive Assessment Methods to Predict the Risk of Metabolic Syndrome
This study aimed to develop non-invasive assessment indictors for predicting the risk of metabolic syndrome. A cross-sectional study design with 154 convenient subjects recruited from the family clinics was used for this study. Physical assessment sheet, lifestyle profile, the heart rate variability assessment and standard blood sample tests were used to measure variables. The subjects were categorized into four groups based on the number of factors meeting the criteria for metabolic syndrome. After excluding invasive blood tests, the results of multivariate logistic regression identified non-invasive assessment (blood pre...
Source: Applied Nursing Research : ANR - December 17, 2014 Category: Nursing Authors: Der-Yun Hsiung, Chia-Wei Liu, Pi-Chen Cheng, Wei-Fen Ma Tags: Original Articles Source Type: research

Salivary glucose exhibits threshold kinetics
Hartman ML, Goodson JM, Barake R, Alsmadi O, Al-Mutawa S, Ariga J, Soparkar P, Behbehani J, Behbehani K, Welty F (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - December 16, 2014 Category: Endocrinology Source Type: research

Improved Arterial–Ventricular Coupling in Metabolic Syndrome after Exercise Training: A Pilot Study
Conclusions: These findings have clinical importance because they provide insight that some of the pathophysiological changes associated with MetS can be improved and can lower the risk of CV disease. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - December 16, 2014 Category: Sports Medicine Tags: Clinical Sciences Source Type: research

Canadian Health Measures Survey: Selected laboratory and activity monitor data, 2012 and 2013
Unhealthy cholesterol levels were measured or self-reported in over one-third of Canadian adults in 2012 and 2013, according to selected laboratory data from cycle 3 of the Canadian Health Measures Survey (CHMS). Other findings show that one-fifth of Canadian adults were measured or reported having three or more cardiometabolic risk factors (metabolic syndrome), while one-third of Canadians were 'potentially at risk' or 'at risk' of inadequate vitamin D. (Source: Statistics Canada, The Daily: Health)
Source: Statistics Canada, The Daily: Health - December 16, 2014 Category: Statistics Source Type: research

Product/Study: Metabolic syndrome in adults, 2012 to 2013, Health Fact Sheets
Catalogue number 82-625-X201400114123 (Source: Statistics Canada, The Daily: Health)
Source: Statistics Canada, The Daily: Health - December 16, 2014 Category: Statistics Source Type: research

The relationship between lifetime suicide attempts, serum lipid levels, and metabolic syndrome in patients with bipolar disorders
International Journal of Psychiatry in Clinical Practice, Ahead of Print. (Source: International Journal of Psychiatry in Clinical Practice)
Source: International Journal of Psychiatry in Clinical Practice - December 16, 2014 Category: Psychiatry Tags: article Source Type: research

Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats
Evolution of metabolic syndrome is associated with a progressive reduction in skeletal muscle microvessel density, known as rarefaction. Although contributing to impairments to mass transport and exchange, the temporal development of rarefaction and the contributing mechanisms that lead to microvessel loss are both unclear and critical areas for investigation. Although previous work suggests that rarefaction severity in obese Zucker rats (OZR) is predicted by the chronic loss of vascular nitric oxide (NO) bioavailability, we have determined that this hides a biphasic development of rarefaction, with both early and late com...
Source: AJP: Heart and Circulatory Physiology - December 16, 2014 Category: Cardiology Authors: Frisbee, J. C., Goodwill, A. G., Frisbee, S. J., Butcher, J. T., Brock, R. W., Olfert, I. M., DeVallance, E. R., Chantler, P. D. Tags: CALL FOR PAPERS Source Type: research

Plasma Concentrations of Afamin Are Associated With the Prevalence and Development of Metabolic Syndrome [Original Articles]
Conclusions— This study in transgenic mice and >5000 participants in epidemiological studies shows that afamin is strongly associated with the prevalence and development of metabolic syndrome and all its components. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 16, 2014 Category: Cardiology Authors: Kronenberg, F., Kollerits, B., Kiechl, S., Lamina, C., Kedenko, L., Meisinger, C., Willeit, J., Huth, C., Wietzorrek, G., Altmann, M. E., Thorand, B., Melmer, A., Dahnhardt, D., Santer, P., Rathmann, W., Paulweber, B., Koenig, W., Peters, A., Adham, I. M. Tags: Animal models of human disease, Risk Factors, Other diagnostic testing Original Articles Source Type: research

Human Plasma Lipidome Is Pleiotropically Associated With Cardiovascular Risk Factors and Death [Original Articles]
Conclusions— The human plasma lipidome is heritable. Shared genetic influences reduce the dimensionality of the human lipidome into clusters that are associated with risk factors of CVD. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 16, 2014 Category: Cardiology Authors: Bellis, C., Kulkarni, H., Mamtani, M., Kent, J. W., Wong, G., Weir, J. M., Barlow, C. K., Diego, V., Almeida, M., Dyer, T. D., Goring, H. H. H., Almasy, L., Mahaney, M. C., Comuzzie, A. G., Williams-Blangero, S., Meikle, P. J., Blangero, J., Curran, J. E. Tags: Genetics of cardiovascular disease, Lipid and lipoprotein metabolism Original Articles Source Type: research

The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population
Conclusion: Short-term dietary supplementation with BO and FO improved biomarkers associated with T2D/metabolic syndrome.Trial registration: Clinicaltrial.gov NCT01145066 (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - December 16, 2014 Category: Lipidology Authors: Tammy LeePriscilla IvesterAustin HesterSusan SergeantLarry CaseTimothy MorganEthel KoubaFloyd Chilton Source Type: research

Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation
Conclusion: This study demonstrates that fructose as a sole source of energy modulates plasma lipids and hsCRP levels in healthy individuals. The significance of increase in HDL-cholesterol with a concurrent increase in LDL-cholesterol and elevated hs-CRP levels remains to be delineated when considering health effects of feeding fructose-rich diets.Registration number for clinical trials: ACTRN12614000431628 (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - December 16, 2014 Category: Lipidology Authors: Faizan JameelMelinda PhangLisa WoodManohar Garg Source Type: research

Cross-cultural Adaptation and Validation to Brazilian Portuguese of Two Measuring Adherence Instruments for Patients with Type 1 Diabetes
Conclusions: The Brazilian Portuguese versions of DSMP and SCI-R yielded a reliable and valid tool to measure adherence treatment for patients with type 1 diabetes, with a significant correlation between total scores and A1C. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - December 16, 2014 Category: Endocrinology Authors: Gabriela TelóMartina de SouzaBeatriz Schaan Source Type: research

Reducing complexity: a visualisation of multimorbidity by combining disease clusters and triads
Conclusions: We were able to show which diseases were associated with each other in our data set, to which clusters the diseases were assigned, and which diseases were responsible for overlapping clusters. The disease with the highest number of associations, and the most important mediator between diseases, was chronic low back pain. In females, depression was also associated with many other diseases. We found a multitude of associations between disorders of the metabolic syndrome of which hypertension was the most central disease. The most prominent bridges were between the metabolic syndrome and musculoskeletal disorders...
Source: BMC Public Health - December 16, 2014 Category: Consumer Health News Authors: Ingmar SchäferHanna KaduszkiewiczHans-Otto WagnerGerhard SchönMartin SchererHendrik van den Bussche Source Type: research

Walk-Run Training Improves the anti-inflammation Properties of High-Density Lipoprotein in the Patients with Metabolic Syndrome.
Conclusion: Walk/run training leads to a significant improvement in HDL anti-inflammation capacity in subjects with MetS without restricted diet, the mechanism underlying which at least partially is due to increased PON1 activity in HDL, NO production and eNOS expression in endothelial cell. PMID: 25514103 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 16, 2014 Category: Endocrinology Authors: Sang H, Yao S, Zhang L, Li X, Yang N, Zhao J, Zhao L, Si Y, Zhang Y, Lv X, Xue Y, Qin S Tags: J Clin Endocrinol Metab Source Type: research

Irisin in response to exercise in humans with and without metabolic syndrome.
Conclusions: Exercise is able to increase circulating irisin levels in individuals with the metabolic syndrome as well as healthy individuals. Whether this increase may contribute to the beneficial effects of exercise on patients with the metabolic syndrome remains to be studied further. PMID: 25514098 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 16, 2014 Category: Endocrinology Authors: Young Huh J, Siopi A, Mougios V, Hee Park K, Mantzoros CS Tags: J Clin Endocrinol Metab Source Type: research

Effectiveness of a telemedicine programme for patients with metabolic syndrome.
CONCLUSIONS: Telemedicine allows for better control of some of the defining parameters of metabolic syndrome than is achieved by routine clinical practice. Teletransmission is viable and satisfactory, and constitutes a novel contribution to the clinical management of these patients. PMID: 25515052 [PubMed - as supplied by publisher] (Source: Technology and Health Care)
Source: Technology and Health Care - December 16, 2014 Category: Medical Equipment Authors: López-Torres J, Rabanales J, Osé Simarro And On Behalf Of The Pites-Albacete Group M Tags: Technol Health Care Source Type: research

Association of health outcomes and diabetics quality metrics
Takahashi PY, St Sauver JL, Finney Rutten LJ, Jacobson RM, Jacobson DJ, McGree ME, Ebbert JO (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - December 15, 2014 Category: Endocrinology Source Type: research

The relationship between glycemic variability and diabetic peripheral neuropathy in type 2 diabetes with well-controlled HbA1c
Conclusions: There was a close relationship between glycemic variability evaluated by MAGE and DPN in type 2 diabetes with well-controlled HbA1c. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - December 15, 2014 Category: Endocrinology Authors: Feng XuLi-hua ZhaoJian-bin SuTong ChenXue-qin WangJin-feng ChenGang WuYan JinXiao-hua Wang Source Type: research

IJERPH, Vol. 11, Pages 13065-13073: The Development of a Bilingual Interactive Video to Improve Physical Activity and Healthful Eating in a Head Start Population
This article describes the development and assessment of a group of bilingual interactive video interventions to improve age appropriate physical activity while providing basic nutrition education focusing on increasing vegetable and water intake and decreasing sugar sweetened beverages. Suggestions for development and assessment of content were provided by focus groups of Head Start teachers, managers and dietitians in the Texas counties of Bastrop, Hidalgo and McLennon. A demonstration of the videos was conducted in Bastrop County. Teachers, students and managers felt that the videos provided excellent information, impro...
Source: International Journal of Environmental Research and Public Health - December 15, 2014 Category: Environmental Health Authors: Veronica Piziak Tags: Article Source Type: research

Cardiac NO signalling in the metabolic syndrome
It is well documented that metabolic syndrome (i.e. a group of risk factors, such as abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides and low cholesterol level in high‐density lipoprotein), which raises the risk for heart disease and diabetes, is associated with increased reactive oxygen and nitrogen species (ROS/RNS) generation. ROS/RNS can modulate cardiac NO signalling and trigger various adaptive changes in NOS and antioxidant enzyme expressions/activities. While initially these changes may represent protective mechanisms in metabolic syndrome, later with more prol...
Source: British Journal of Pharmacology - December 15, 2014 Category: Drugs & Pharmacology Authors: O Pechánová, Z V Varga, M Cebová, Z Giricz, P Pacher, P Ferdinandy Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research