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Prevalence, Risk Factors, and Comorbidities of Hidradenitis Suppurativa
It is challenging to estimate a true prevalence of hidradenitis suppurativa (HS) because it is underdiagnosed and misdiagnosed. Prevalences have been reported from 0.00033% to 4.1%. The incidence seems to be rising. In addition to dermatologic symptoms, HS is associated with metabolic syndrome, and increased cardiovascular risk. The majority of HS patients are smokers. Additional somatic comorbidities complicating HS include autoimmune conditions, follicular syndromes, rheumatologic conditions, and malignancies. HS patients are troubled by psychological comorbidities. When treating HS patients it is imperative not only to ...
Source: Dermatologic Clinics - November 28, 2015 Category: Dermatology Authors: Iben Marie Miller, Rachel J. McAndrew, Iltefat Hamzavi Source Type: research

Endocrinologic Aspects of Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of unknown etiology. The role of hormones in HS remains unclear, but the observation of premenstrual flares, female predominance, and improvement during pregnancy suggest a hormonal/metabolic background. The reported positive effects of antiandrogen therapy supports a possible role of androgens. The predominant onset of the disease years after puberty may indicate a metabolic disorder. Obesity contributes significantly to HS pathogenesis; diabetes, dyslipidemia, the metabolic syndrome, and polycystic ovarian syndrome are among the commonest comorbidities...
Source: Dermatologic Clinics - November 28, 2015 Category: Dermatology Authors: Ioannis Karagiannidis, Georgios Nikolakis, Christos C. Zouboulis Source Type: research

The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue.
Authors: Peredo-Escárcega AE, Guarner-Lans V, Pérez-Torres I, Ortega-Ocampo S, Carreón-Torres E, Castrejón-Tellez V, Díaz-Díaz E, Rubio-Ruiz ME Abstract Resveratrol (RSV) and quercetin (QRC) modify energy metabolism and reduce cardiovascular risk factors included in the metabolic syndrome (MetS). These natural compounds upregulate and activate sirtuins (SIRTs), a family of NAD-dependent histone deacetylases. We analyzed the effect of two doses of a commercial combination of RSV and QRC on serum fatty acid composition and their regulation of SIRTs 1-3 and PPAR-γ expression in white adipose tissue. MetS was in...
Source: Evidence-based Complementary and Alternative Medicine - November 28, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Metabolic syndrome in schizophrenia - who is more to blame: FGA polypharmacy or clozapine monotherapy?
CONCLUSION: Compared to polypharmacy with first generation antipsychotics, the higher prevalence of metabolic syndrome is found in patients treated with Clozapine alone. The most prevalent metabolic disorder is dyslipidemia. PMID: 26609650 [PubMed - as supplied by publisher] (Source: Psychiatria Danubina)
Source: Psychiatria Danubina - November 27, 2015 Category: Psychiatry Tags: Psychiatr Danub Source Type: research

Effects of Berberine on Adipose Tissues and Kidney Function in 3T3-L1 Cells and Spontaneously Hypertensive Rats.
Authors: Kishimoto A, Dong SF, Negishi H, Yasui N, Sun JN, Ikeda K Abstract We aimed to investigate the effect of berberine on adipose tissues, as well as its effect on renal injury in 3T3-L1 cells and spontaneously hypertensive rats. 3T3-L1 cells were cultured and treated with berberine (5-20 pM) from days 3 to 8. Berberine added to the cultured medium could significantly down-regulate transcription factors, including CCAAT/enhancer binding protein β, CCAAT/enhancer binding protein a, and peroxisome pro liferator-activated receptor y, and suppress peroxisome proliferator-activated receptor target genes, such as a...
Source: Natural Product Communications - November 27, 2015 Category: Biochemistry Tags: Nat Prod Commun Source Type: research

Retrospective comparison of voglibose or acarbose as an add-on therapy to sulfonylureas in Western Indian patients with uncontrolled overweight/obese type 2 diabetes
Conclusion Voglibose or acarbose as an add-on treatment with metformin and sulfonylureas in uncontrolled obese/overweight T2DM provide desired glycemic control, reduces bodyweight and improve lipid parameters with good tolerability profile. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 27, 2015 Category: Endocrinology Source Type: research

A Prospective Study of Weight and Metabolic Syndrome in Young Hispanic Children.
CONCLUSIONS: Overweight appears to be an independent predictor of MS among Hispanic children. PMID: 20548797 [PubMed - as supplied by publisher] (Source: Children's Health Care)
Source: Children's Health Care - November 26, 2015 Category: Pediatrics Tags: Child Health Care Source Type: research

Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study.
CONCLUSIONS: Although preliminary, our findings suggest that a bioavailable form of curcumin is well-tolerated and can positively influence weight management in overweight people. PMID: 26592847 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - November 26, 2015 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Resting heart rate as a predictor of aortic valve stenosis progression
Calcific aortic valve stenosis (AVS) is the most common valve disease in the Western world [1]. Given the aging population and the marked individual variability in the rate of AVS progression, along with the implementation of less invasive treatment modalities, clinical and echocardiographic assessment of AVS patients is becoming increasingly important. Various predictors of AVS progression have previously been recognized including diabetes, the metabolic syndrome, aortic valve calcifications and hemodynamic severity of stenosis [2–5], all of which may allow for a better identification of patients at risk for accelerated...
Source: International Journal of Cardiology - November 26, 2015 Category: Cardiology Authors: Adriana Benjamim de Oliveira Moraes, Barbara E. Stähli, Benoit J. Arsenault, David Busseuil, Nolwenn Merlet, Catherine Gebhard, Annik Fortier, David Rhainds, Marie-Pierre Dubé, Marie-Claude Guertin, Anita Asgar, Eric Rhéaume, Jean-Claude Tardif Tags: Correspondence Source Type: research

Consequences of Obstructive Sleep Apnea in Children
Obstructive sleep apnea syndrome (OSAS) has various negative health and behavioral consequences in the pediatric population. As shown in adults, there are metabolic derangements such as obesity, insulin sensitivity, dyslipidemia, and metabolic syndrome, as well as cardiovascular derangements like hypertension, chronic inflammation, endothelial dysfunction, ventricular size/function abnormalities, and even elevated pulmonary arterial pressures, that can be seen in children with OSAS. The first two sections will discuss the metabolic and cardiovascular consequences on OSAS in children. (Source: Current Problems in Pediatric ...
Source: Current Problems in Pediatric and Adolescent Health Care - November 26, 2015 Category: Pediatrics Authors: Michael Blechner, Ariel A. Williamson Source Type: research

Immunosenescence of the CD8 + T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls
Conclusions: HIV-infection strongly affected CD8 + T cell differentiation and maturation, whereas age-related processes were only weakly associated with immune parameters. Our findings suggest that, in contrast to inflammation, immunosenescence appears to be highly dependent on HIV-infection and is only to a small extent associated with age-related parameters in well-treated HIV-infection. (Source: BMC Immunology)
Source: BMC Immunology - November 26, 2015 Category: Allergy & Immunology Authors: Juliette TavenierAnne LangkildeThomas HauptJens HenriksenFrank JensenJanne PetersenOve Andersen Source Type: research

Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
ConclusionsThese findings suggest that childhood obesity may be associated with variations in RBP4 gene. The presence of selective SNPs in the RBP4 gene may account for metabolic complications. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 26, 2015 Category: Endocrinology Authors: Pilar Codoñer‐Franch, Joaquín Carrasco‐Luna, Paula Allepuz, Alan Codoñer‐Alejos, Vicent Guillem Tags: Original Article Source Type: research

Trends in mortality due to diabetes in Brazil, 1996–2011
Conclusion: Mortality due to diabetes declined in Brazil from 1996 to 2011, minimally in men and considerably in women. The lesser declines in recent years may reflect the increasing prevalence of diabetes, and suggest that current efforts to prevent diabetes and minimize the impact of its complications need to be reinforced to ensure that declines will continue. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - November 26, 2015 Category: Endocrinology Authors: Maria SchmidtBruce DuncanLenice IshitaniGlaura da Conceição FrancoDaisy de AbreuGustavo LanaElisabeth França Source Type: research

Diabetes knowledge, attitude and practice (KAP) study among Iranian in-patients with type-2 diabetes: A cross-sectional study
Conclusions The results of this study showed that recent educational programs in Iran improved KAP level. Patients’ KAP increases as their condition worsens/progresses. Hence education should be considered as a priority for newly diagnosed patients and those with lower KAP levels before occurrence of diabetes complications. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2015 Category: Endocrinology Source Type: research

The association of circulating levels of complement-C1q TNF-related protein 5 (CTRP5) with nonalcoholic fatty liver disease and type 2 diabetes: a case–control study
Background: It is well-established that nonalcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes mellitus (T2DM). Complement-C1q TNF-related protein 5 (CTRP5) is a novel adipokine involved in the regulation of lipid and glucose metabolism. We aimed to assess plasma levels of CTRP5 in patients with NAFLD (n = 22), T2DM (n = 22) and NAFLD with T2DM (NAFLD + T2DM) (n = 22) in comparison with healthy subjects (n = 21) and also to study the association between CTRP5 levels and NAFLD and diabetes-related parameters. Methods: All subjects underwent anthropometric assessment, biochemical evaluation and...
Source: Diabetology and Metabolic Syndrome - November 25, 2015 Category: Endocrinology Authors: Solaleh EmamgholipourNariman MoradiMaani BeigyParisa ShabaniReza FadaeiHossein PoustchiMahmood Doosti Source Type: research

DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats
Conclusion: Our study suggests that sitagliptin treatment in 2K1C rats prevented inflammation and fibrosis of heart and kidney by ameliorating elevated oxidative stress in heart and kidney tissues. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - November 25, 2015 Category: Endocrinology Authors: Md. AlamMohammed ChowdhuryPreeti JainMd. SagorHasan Reza Source Type: research

The metabolic syndrome, coronary artery calcium score and cardiovascular risk reclassification
Recent guidelines propose the use of the Atherosclerotic Cardiovascular Disease score (ASCVD) to assess an individual's risk of future cardiovascular disease (CVD) events. However, limited information exist on its predictive performance among patients with the metabolic syndrome (MetS) [1]. The MetS is comprised of many of the constitutive risk factors included in ASCVD score (dyslipidemia, hypertension and glucose intolerance), is influenced by a number of genetic and environmental factors [2], and is a major risk factor for CVD [3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 25, 2015 Category: Cardiology Authors: Marat Fudim, Sandip Zalawadiya, Devin K. Patel, Ugochukwu O. Egolum, Luis Afonso Tags: Correspondence Source Type: research

A perspective on NETosis in diabetes and cardiometabolic disorders
Conclusions NETosis appears to be part of an abnormal response to damage in diabetes that, in turn, can promote or aggravate end-organ complications. We suggest that this will be a hot topic of investigation in diabetology in the near future. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - November 25, 2015 Category: Nutrition Source Type: research

Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin‐8 (CXCL8), Myeloid‐Related Protein 8/Myeloid‐Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease
ConclusionCirculating levels of CXCL8 are increased during both the acute and intercritical phases of gout, and they coincide with a specific circulating proteome that is associated with risk of diabetes mellitus and CVD. Further research focused on the roles of CXCL8 and MRP8/MRP14 complex in patients with gout is warranted. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 25, 2015 Category: Rheumatology Authors: Laura B. E. Kienhorst, Ellen van Lochem, Wietske Kievit, Nicola Dalbeth, Marilyn E. Merriman, Amanda Phipps‐Green, Arnoud Loof, Waander van Heerde, Sita Vermeulen, Lisa K. Stamp, Elly van Koolwijk, Jacqueline de Graaf, Dirk Holzinger, Johannes Roth, Hei Tags: Gout Source Type: research

The role of liver progenitor cells during liver regeneration, fibrogenesis and carcinogenesis.
Abstract The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity and the metabolic syndrome has sparked interest in stem cell-like liver progenitor cells (LPCs) as potential candidates for cell therapy and tissue engineering as an alternative approach to whole organ transplantation. However LPCs always proliferate in chronic liver diseases with a predisposition to cancer; they have been suggested to play major roles in driving fibrosis, disease progression and may even represent tumour-initiating cells. Hence, ...
Source: Am J Physiol Gastroi... - November 25, 2015 Category: Gastroenterology Authors: Köhn-Gaone J, Gogoi-Tiwari J, Ramm GA, Olynyk JK, Tirnitz-Parker JE Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Prevalence of metabolic syndrome and cardiovascular risk factors among voluntary screened middle-aged and elderly Egyptians
Conclusion The high prevalence of MetS among middle-aged and elderly Egyptians with the documented high prevalence of chronic diseases in Egypt calls for a nationwide screening program to detect MetS and tackle preventive strategies to face the epidemic of obesity and outcomes of MetS, particularly cardiovascular diseases. (Source: Journal of Public Health)
Source: Journal of Public Health - November 25, 2015 Category: Health Management Authors: Abd Elaziz, K. M., Gabal, M. S., Aldafrawy, O. A., Abou Seif, H. A.-A., Allam, M. F. Tags: Life course [amp ] epidemiology Source Type: research

Optimal cutoff points for HOMA-IR and QUICKI in the diagnosis of metabolic syndrome and non-alcoholic fatty liver disease: a population based study
The present study was carried out to determine the optimal cutoff points for homeostatic model assessment (HOMA-IR) and Quantitative insulin sensitivity check index (QUICKI) in the diagnosis of metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - November 25, 2015 Category: Endocrinology Authors: Nima Motamed, Seyed Javad Haji Miresmail, Behnam Rabiee, Hossein Keyvani, Behzad Farahani, Mansooreh Maadi, Farhad Zamani Source Type: research

Change in the prevalence of metabolic syndrome in a population of medical students: 6-year follow-up
Abstract Students of a university hospital were assessed in 2007 and later in 2013 to determine the prevalence of metabolic syndrome. Statistical analysis was done with SPSS version 17.0. A total of 213 students were evaluated in both 2007 and 2013 (48.3 % women and 51.7 % men). The diagnosis of overweight and obesity increased from 24.9 to 37.1 % (p < 0.05), central obesity from 17.8 to 28.6 % (p < 0.05), and prevalence of metabolic syndrome from 9.8 to 14.5 % (p ≥ 0.05); up to 20 % in male gender. It is important to implement programs for early diagnosis of metabolic syndrome...
Source: Journal of Diabetes and Metabolic Disorders - November 25, 2015 Category: Endocrinology Source Type: research

Progression of arterial stiffness and vascular lesions according to the degree of glycemic abnormalities. A warning in patients with metabolic syndrome
Introduction: Metabolic Syndrome (MS), is postulated as intermediate stage in the way to overt DBT, and probably the degree of vascular compromise in this stage could explain the higher proportion of CV complications in diabetics. If so, it should deserve an intensive prevention in MS to reduce DBT complications. (Source: Artery Research)
Source: Artery Research - November 24, 2015 Category: Cardiology Authors: Pedro Forcada, Carlos Castellaro, Jorge Chiabaut, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon Source Type: research

Association of carotid intima-media thickness, endothelial function and aortic stiffness with cardiovascular events in metabolic syndrome patients
The objective of this study was to assess predictive value of various arterial markers for cardiovascular (CV) events in patients with metabolic syndrome (MS). (Source: Artery Research)
Source: Artery Research - November 24, 2015 Category: Cardiology Authors: Ligita Ryliskyte, Jurate Balsyte, Jolita Badariene, Roma Puronaite, Rokas Navickas, Svetlana Solovjova, Kristina Ryliskiene, Jurgita Kuzmickiene, Aleksandras Laucevicius Source Type: research

Vascular endothelial senescence and metabolic syndrome
We examined whether MS accelerates the progression of vascular aging. (Source: Artery Research)
Source: Artery Research - November 24, 2015 Category: Cardiology Authors: Dimitrios Terentes-Printzios, Charalambos Vachopoulos, Nikolaos Ioakeimidis, Athanasios Aggelis, Panagiotis Xaplanteris, Panagiota Pietri, Dimitrios Tousoulis Source Type: research

Does red yeast rice and olive extract reduce cardiovascular risk in metabolic syndrome?
(Source: Focus on Alternative and Complementary Therapies)
Source: Focus on Alternative and Complementary Therapies - November 24, 2015 Category: Complementary Medicine Authors: M Johannsson Tags: Summaries and Commentaries Source Type: research

Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - November 24, 2015 Category: Pathology Authors: Roger M Feakins Tags: Review Source Type: research

Sugar-sweetened beverage consumption is linked to global adult morbidity and mortality through diabetes mellitus, cardiovascular disease and adiposity-related cancers
Commentary on: Singh GM, Micha R, Khatibzadeh S, et al., Global Burden of Diseases Nutrition and Chronic Diseases Expert Group (NutriCoDE). Estimated global, regional, and national disease burdens related to sugar-sweetened beverage consumption in 2010. Circulation 2015;132:639–66 . Context Obesity and obesity-related non-communicable diseases are global health burdens associated with all-cause and cause-specific mortality, economic costs and impaired quality of life.1–3 Sugar-sweetened beverage (SSB) consumption has been linked with obesity and has long been thought to contribute to cardiometabolic diseases th...
Source: Evidence-Based Medicine - November 24, 2015 Category: Internal Medicine Authors: Ruff, R. R. Tags: Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Diet, Obesity (nutrition), Dentistry and oral medicine, Diabetes, Health education Aetiology/Harm Source Type: research

Clinical patterns of hepatocellular carcinoma (hcc) in non alcoholic fatty liver disease (NAFLD): A multicenter prospective study
Conclusions: NAFLD‐HCC and is more often detected at a later tumor stage and could arise also in the absence of cirrhosis. However after patient matching, NAFLD‐HCC has a similar survival as compared to HCV‐infected patients. Future challenge will be to identify patients with NAFLD who require more stringent surveillance in order to offer the most timely and effective treatment. This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 24, 2015 Category: Internal Medicine Authors: Fabio Piscaglia, Gianluca Svegliati‐Baroni, Andrea Barchetti, Anna Pecorelli, Sara Marinelli, Claudio Tiribelli, Stefano Bellentani, Tags: Hepatobiliary Malignancies Source Type: research

A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia
Metabolic syndrome (MetS) is a cluster of factors that increases the risk of cardiovascular disease (CVD), one of the leading causes of mortality in patients with schizophrenia. Incidence rates of MetS are significantly higher in patients with schizophrenia compared to the general population. Several factors contribute to this high comorbidity. This systematic review focuses on genetic factors and interrogates data from association studies of genes implicated in the development of MetS in patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 24, 2015 Category: Psychiatry Authors: Stefanie Malan-Müller, Sanja Kilian, Leigh L. van den Heuvel, Soraya Bardien, Laila Asmal, Louise Warnich, Robin A. Emsley, Sîan M.J. Hemmings, Soraya Seedat Source Type: research

The role of epicardial adipose tissue in heart disease: a review.
Abstract Recent studies focused on epicardial fat, formerly relatively neglected component of the heart, have elucidated some of its key roles. It possesses several properties that can distinguish it from other adipose tissue depots. Its unique anatomical location in the heart predisposes the epicardial fat to be an important player in the physiological and biochemical regulation of cardiac homeostasis. Obesity is associated with an increase in epicardial fat mass. Excess of cardiac fat can contribute to greater left ventricular mass and work, diastolic dysfunction and attenuated septal wall thickening. Imbalance i...
Source: Physiological Research - November 24, 2015 Category: Physiology Authors: Matloch Z, Kotulák T, Haluzík M Tags: Physiol Res Source Type: research

Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1
Conclusions These results indicate that five newly described SNPs in the hURAT1 gene are significantly associated with uric acid level (4-2008-0318 and 4-2011-0277). (Source: BMJ Open)
Source: BMJ Open - November 24, 2015 Category: Journals (General) Authors: Cho, S. K., Kim, S., Chung, J.-Y., Jee, S. H. Tags: Open access, Genetics and genomics, Pharmacology and therapeutics Research Source Type: research

The famine exposure in early life and metabolic syndrome in adulthood
Epidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure to Chinese famine between 1959 and 1962 during fetal and childhood period was related with metabolic syndrome (MS) in adulthood. (Source: Clinical Nutrition)
Source: Clinical Nutrition - November 24, 2015 Category: Nutrition Authors: Ningjian Wang, Xiaojin Wang, Qin Li, Bing Han, Yi Chen, Chunfang Zhu, Yingchao Chen, Dongping Lin, Bingshun Wang, Michael D. Jensen, Yingli Lu Tags: Original article Source Type: research

The modulation of adiponectin by STAT5 activating hormones.
In this study, we demonstrate that 3T3-L1 adipocytes treated with GH or PRL exhibit a reduction in adiponectin protein levels. Furthermore, we identified three putative STAT5 binding sites in the murine adiponectin promoter and show that only one of these, located at -3809, binds nuclear protein in a GH or PRL dependent manner. Mutation of the STAT5 binding site reduced PRL-dependent protein binding, and supershift analysis revealed that STATs 5A and 5B, but not STATs 1 and 3, bind to this site in response to PRL. Chromatin IP analysis demonstrated that only STAT5A, and not STAT1 and 3, bind to the murine adiponectin promo...
Source: Am J Physiol Endocri... - November 24, 2015 Category: Endocrinology Authors: White UA, Maier J, Zhao P, Richard AJ, Stephens JM Tags: Am J Physiol Endocrinol Metab Source Type: research

High‐fat Diet‐induced Intestinal Hyperpermeability is Associated with Increased Bile Acids in the Large Intestine of Mice
This study examined the effects of 3 high‐fat diets (HFDs) composed of different fat sources (soybean oil and lard) on the intestinal permeability, tight junction (TJ) protein expression, and cecal bile acid (BA) concentrations in mice, and then analyzed their interrelations. C57/BL6 mice were fed the control diet, HFD (soybean oil), HFD (lard), and HFD (mix; containing equal concentrations of soybean oil and lard) for 8 wk. Glucose tolerance, intestinal permeability, TJ protein expression, and cecal BA concentration were evaluated. Feeding with the 3 HDFs similarly increased body weight, liver weight, and fat pad weight...
Source: Journal of Food Science - November 23, 2015 Category: Food Science Authors: Yuki Murakami, Soichi Tanabe, Takuya Suzuki Tags: H: Health, Nutrition & Food Source Type: research

Is the metabolic syndrome inversely associates with butter, non-hydrogenated- and hydrogenated-vegetable oils consumption: Tehran Lipid and Glucose Study
Metabolic Syndrome (MetS), a common metabolic abnormality, is strongly associated with several diet-related chronic diseases, such as type 2 diabetes, chronic kidney disease, and cardiovascular disease (CVD) [1,2]. In recent years, the remarkably increasing prevalence of this syndrome reflects changes the effects that lifestyle factors, including diet have on its etiology [3,4]. Dietary fat has long been the source of interest in insulin resistance and MetS [5]. One specific type of dietary fatty acids that has received considerable attention is trans fatty acids (TFAs). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - November 23, 2015 Category: Endocrinology Authors: Somayeh Hosseinpour-Niazi, Parvin Mirmiran, Firoozeh Hosseini-Esfahani, Fereidoun Azizi Source Type: research

Indian Diabetes Risk Score and Clustering of Metabolic Syndrome Phenotype in a Rural Community of Asian Indian Origin
Diabetes is one of the major non-communicable diseases (NCDs) of the world and one of the most important leading causes of death globally. Individuals with coexisting diabetes and metabolic syndrome (MS) had the highest prevalence rates of cardiovascular disease (CVD) [1]. Risk of CVD in individuals with diabetes was shown to increase by 2 to 4 folds compared with individuals without diabetes [2]. About 387 million people have diabetes worldwide which is predicted to 592 million by 2035 and diabetes caused 4.9 million deaths in 2014 [3]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - November 23, 2015 Category: Endocrinology Authors: Tanmay Nag, Arnab Ghosh Source Type: research

Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome
Conclusion The presence of homozygote polymorphic variant of BclI might be good predictive markers for the disease susceptibility. The BclI and the TthIII1 polymorphism are associated with sex-specific clinical parameters. Our findings also suggest that the combination of BclI and TthIII1 polymorphisms may play a protective role in blood glucose. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 23, 2015 Category: Endocrinology Source Type: research

Recurrent pre-eclampsia in women with metabolic syndrome and low plasma volume: a retrospective cohort study.
CONCLUSIONS: In the concomitant presence of metabolic syndrome and low plasma volume, the prevalence of recurrent pre-eclampsia was nearly 50%, which is four times as high as the prevalence in women without either entity. TWEETABLE ABSTRACT: Metabolic syndrome and low plasma volume raise the risk of recurrent pre-eclampsia to nearly 50%. PMID: 26589850 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - November 22, 2015 Category: OBGYN Authors: Stekkinger E, Scholten RR, Heidema WM, Spaanderman M Tags: BJOG Source Type: research

Editorial: Aging and Metabolic Syndrome: Common Molecular Pathways.
PMID: 26585274 [PubMed - in process] (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - November 22, 2015 Category: Endocrinology Authors: Illario M Tags: Curr Diabetes Rev Source Type: research

Patients with normocalcemic primary hyperparathyroidism may have similar metabolic profile as hypercalcemic patients.
In conclusion, patients with NC-PHPT may be prone to similar metabolic disturbances linked to higher cardiovascular risk like patients with HC-PHPT. Although NC-PHPT is thought to occur early in the development of the classical disease, it should be monitored regularly because of its metabolic consequences. PMID: 26581584 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 22, 2015 Category: Endocrinology Tags: Endocr J Source Type: research

Glycated apolipoprotein B—A surrogate marker of subclinical atherosclerosis
Conclusion Persistent hyperglycemia and sdLDL are independently associated with glycation of apo B. Presence of plaques and increased thickness of intima indicates that glycated apo B predisposes diabetics to atherosclerosis. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 22, 2015 Category: Endocrinology Source Type: research

Which is responsible for cardiac autonomic dysfunction in non-diabetic patients with metabolic syndrome: Prediabetes or the syndrome itself?
Conclusions This study confirms the relation between MS and CAD. Increased FPG alone appears to be responsible for the mentioned findings among the 5 diagnostic criteria. Accordingly, CAD may be the result of prediabetes, not MS in patients with MS. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 22, 2015 Category: Endocrinology Source Type: research

High prevalence of asymptomatic carriers of Tropheryma whipplei in different populations from the North of Spain.
CONCLUSIONS: There is a high prevalence of asymptomatic carriers of T. whipplei among healthy and in HIV-infected people from Spain. The role of T. whipplei in HIV patients with MS is unclear, but the prevalence is higher than in other populations. PMID: 26585816 [PubMed - as supplied by publisher] (Source: Enfermedades Infecciosas y Microbiologia Clinica)
Source: Enfermedades Infecciosas y Microbiologia Clinica - November 21, 2015 Category: Microbiology Tags: Enferm Infecc Microbiol Clin Source Type: research

[Prevalence of cardiovascular risk factors in an urban ambulatory adult population: AsuRiesgo study, Paraguay].
CONCLUSIONS: Although the prevalence rates of smoking, systemic hypertension, and diabetes mellitus were low, those for obesity, sedentary lifestyle, psychological stress, unhealthy diet, and metabolic syndrome were very high. This finding demonstrates the need for global action to prevent disability and death from ischemic heart and cerebrovascular disease. It is urgent to implement programs to address these challenges on a national scale. PMID: 26581054 [PubMed - in process] (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - November 21, 2015 Category: Global & Universal Tags: Rev Panam Salud Publica Source Type: research

Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant
This study investigates the impact of coffee intake on T2DM risk and assesses the effect of CYP variants with caffeine exposures on T2DM. Data from 7,607 study subjects were analyzed by logistic regression models, among whom 3,290 GWAS data were available for CYP variants association studies using Plink analysis. These data suggest a protective relationship for women, but not for men; however, the results were not statistically significant in this dataset and there is a significant interaction in favor of women regarding heavy coffee consumption. The interaction between male gender and heavy coffee consumption becomes sign...
Source: Annals of Nutrition and Metabolism - November 21, 2015 Category: Nutrition Source Type: research

Age at menarche and its association with the metabolic syndrome in Taiwan
Conclusions Early onset of menarche is an important risk factor of MetS and may help identify women at risk of MetS. (Source: Obesity Research and Clinical Practice)
Source: Obesity Research and Clinical Practice - November 21, 2015 Category: Eating Disorders and Weight Management Source Type: research

The complex and multifactorial relationship between testosterone deficiency (TD), obesity and vascular disease
Abstract Testosterone deficiency (TD) is a well-established and recognized medical condition that contributes to several co-morbidities, including metabolic syndrome, visceral obesity and cardiovascular disease (CVD). More importantly, obesity is thought to contribute to TD. This complex bidirectional interplay between TD and obesity promotes a vicious cycle, which further contributes to the adverse effects of TD and obesity and may increase the risk of CVD. Testosterone (T) therapy for men with TD has been shown to be safe and effective in ameliorating the components of the metabolic syndrome (Met S) and in cont...
Source: Reviews in Endocrine and Metabolic Disorders - November 21, 2015 Category: Endocrinology Source Type: research

Prevalence of Hypoglycemia Among Diabetic Old Age Home Residents in South India
CONCLUSION : Most guidelines call for an individualized therapeutic approach suing less aggressive strategies for patients vulnerable to hypoglycemia and geriatric population form such a substantial group. The current study highlights the necessity for special attention when considering therapeutic regimen among such patients. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 21, 2015 Category: Endocrinology Source Type: research