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Cardiovascular and Hematological Medicine in 2013 - Advances and Insights.
Cardiovascular and Hematological Medicine in 2013 - Advances and Insights. Cardiovasc Hematol Agents Med Chem. 2012 Dec 11; Authors: Mukherjee D Abstract Welcome to the first issue of Cardiovascular & Hematological Agents in Medicinal Chemistry (CHAMC) for 2013. I hope everyone has had an enjoyable holiday season and I want to wish everyone a wonderful New Year. As you know, our journal (CHAMC) aims to cover the latest and outstanding developments in medicinal chemistry, rational drug design for the discovery of novel cardiovascular and hematological Agents and discusses such therapies in clinical ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Hibiscus sabdariffa Linnaeus (Malvaceae), curcumin and resveratrol as alternative medicinal agents against metabolic syndrome.
Authors: Pérez-Torres I, Ruiz-Ramírez A, Baños G, El-Hafidi M Abstract Metabolic syndrome (MS) is an obesity-associated collection of disorders, each of which contributes to cardiovascular risk. For patients with MS, it is difficult to follow a diet/exercise regime that would improve their symptoms. Therefore, the investigation of agents that may deal with its more serious aspects is an important medical field for research. Numerous experimental studies have confirmed the important role of medicinal plants or their active components in the prevention and treatment, and in lowering risk factors of MS. As oxidativ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Diabetic CVD--focus on vitamin D.
Authors: Bonakdaran S, Rokni H Abstract Cardiovascular disease (CVD) is the leading cause of mortality and morbidity among diabetics. Vitamin D deficiency is very common all over the world. Over last few years, vitamin D has been considered as an important regulating factor for cardiovascular health. Metabolic syndrome and obesity are highly prevalent in vitamin D deficient people. In fact all components of metabolic syndrome are affected by vitamin D. Vitamin D regulates insulin secretion and its action. It has also some controlling effect on Renin-Angiotensin system, which influences cardiomyocytes positively. Vi...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Sex steroid hormones, cardiovascular diseases and the metabolic syndrome.
Authors: Baños G, Guarner V, Pérez-Torres I Abstract The metabolic syndrome (MS) has become the new epidemic of this century. Although its associated pathologies may vary, the most common are hypertension, central obesity, dyslipidemia, low High Density Lipoproteins (HDL), high Low Density Lipoproteins (LDL), and type-2 diabetes. Several others can be present, such as hypertriglyceridemia, cardiopathies, atherosclerosis, altered levels of sex hormones, hypogonadism in men and nephropathy. Several factors such as gender, age, race, lifestyle and diet may contribute to modify its prevalence: men develop cardiovascu...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Association of lipoprotein-associated phospholipase A₂ activity with components of the metabolic syndrome in apparently healthy boys.
CONCLUSION: Lp-PLA(2) activity was only associated with apo B adjusted for several confounding variables, suggesting that its clinical utility to identify individuals at risk for CVD does not surpass LDL-C and apo B in healthy adolescents. As plaque morphology may change with age, associations of Lp-PLA(2) with CVD may likewise vary with age. PMID: 21476960 [PubMed - indexed for MEDLINE] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Hypertension in diabetes: optimal pharmacotherapy.
Authors: Biswas A, Alvarez A, Mukherjee D Abstract Hypertension is commonly associated with diabetes mellitus. The combination of hypertension with obesity and diabetes is a well recognized entity known as the metabolic syndrome, which shares a common pathophysiology of insulin resistance. The individual components of this syndrome act synergistically to substantially increase the risk of renal disease, stroke, coronary artery disease, and death. Hypertension increases both macrovascular and microvascular complications of diabetes such as neuropathy, nephropathy, coronary artery disease, stroke, and retinopathy. He...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Obesity and Oxidative Stress: Potential Roles of Melatonin as Antioxidant and Metabolic Regulator.
Authors: Bonnefont-Rousselot D Abstract Obesity is associated with an oxidative stress status, defined as an excessive production of reactive oxygen species (ROS) compared to the level of antioxidants acting in the natural defence systems. Several sources of ROS can be identified in obesity (e.g., mitochondrial respiratory chain, or NADPH oxidase) and could contribute to the pathogenesis of obesity. Indeed, these conditions favour the development of insulin resistance and metabolic syndrome through deregulation of adipokines and pro-inflammatory cytokines, so that it could be of interest to associate antioxidant th...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 23, 2014 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Impact of oral 1,25-dihydroxy vitamin D (calcitriol) replacement therapy on coronary artery risk factors in type 2 diabetic patients.
CONCLUSION: Replacement of vitamin D may have a beneficial effect on some of the risk factors of CVD in diabetic patients. PMID: 24180458 [PubMed - in process] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 23, 2014 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity
Publication date: 5 August 2014 Source:Molecular and Cellular Endocrinology, Volume 393, Issues 1–2 Author(s): Ling Chen , Yong-Mei Dai , Chen-Bo Ji , Lei Yang , Chun-Mei Shi , Guang-Feng Xu , Ling-Xia Pang , Fang-Yan Huang , Chun-Mei Zhang , Xi-Rong Guo Visceral obesity is an independent risk factor for metabolic syndrome, and abnormal fat accumulation is linked to increases in the number and size of adipocytes. MiR-146b was a miRNA highly expressed in mature adipocytes while very lowly expressed in human mesenchymal stem cells (hMSCs) and human visceral preadipocytes (vHPA). In this paper, we mainly focused on the ro...
Source: Molecular and Cellular Endocrinology - November 23, 2014 Category: Endocrinology Source Type: research

Metabolic syndrome in premenopausal and postmenopausal women with type 2 diabetes: loss of protective effects of premenopausal status
Conclusion: Worsening of MetS and its components except for SBP and waist circumference has been shown in pre-menopausal women with T2DM similar to post-menopausal ones. The observed differences may be explained by increasing age. With respect to increasing of myocardial infarction in premenopausal subjects, we suggest that diabetes can abolish the protective effects of premenopausal status for MetS and MI. (Source: BioMed Central)
Source: BioMed Central - November 23, 2014 Category: Journals (General) Authors: Manouchehr NakhjavaniMehrnaz ImaniMehrdad LarryArash Aghajani-NargesiAfsaneh MortezaAlireza Esteghamati Source Type: research

Metabolic Syndrome Is Correlated With Carotid Atherosclerosis in Patients With Lupus Nephritis
Conclusions:The prevalence of MS was comparatively high in patients with LN and was significantly correlated with carotid atherosclerosis, indicating that MS screening might be useful in the prevention and treatment of carotid atherosclerosis in patients with LN. (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - November 22, 2014 Category: Journals (General) Tags: Clinical Investigation Source Type: research

Health literacy skills in type 2 diabetes mellitus outpatients from an university-affiliated hospital in Rio de Janeiro, Brazil
Conclusion: This study showed that almost a quarter of the participants are illiterate or have inadequate health literacy skills. Therefore, our results indicate the need for the development of health care instructions properly calibrated to the health literacy skills of DM2 patients. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - November 22, 2014 Category: Endocrinology Authors: Simone de CastroGilberto BritoMarilia Gomes Source Type: research

Predictors for pregnancy outcomes in Romanian women with Type 1 Diabetes Mellitus: a prospective study
Background: Type 1 diabetes mellitus in pregnant women is associated with an increased risk of congenital malformations, obstetric complications, neonatal morbidity, and mortality. Our aim was to evaluate which factors from the first trimester of pregnancy have a significant impact on the pregnancy outcomes of women with type 1 diabetes. Methods: We included 94 pregnant women with type 1 diabetes in this study. In these patients, we analyzed the influence of several diabetes-related parameters on the pregnancy outcome. We compared the parameters between two cohorts: those with successful pregnancies and those with adverse ...
Source: Diabetology and Metabolic Syndrome - November 22, 2014 Category: Endocrinology Authors: Bogdan TimarRomulus TimarAlin AlbaiDana StoianRazvan NituMarius Craina Source Type: research

Is lower uric acid level better? A combined cross-sectional and longitudinal study in the elderly
Abstract The relationship between metabolic syndrome (MetS) and uric acid (UA) has been explored in many studies, but there is paucity of information on hypo-uricemia and MetS. The current study aimed to elucidate the relationship between the lower end of UA and MetS in elderly. Subjects aged ≥60 years who underwent routine health checkups were enrolled, and 10,579 were eligible for analysis. A cross-sectional study was first performed to determine the correlation between MetS and UA. The subjects were divided into two groups according to the lowest male MetS prevalence in each UA level (UA ≤5 and >5 mg/...
Source: Endocrine - November 21, 2014 Category: Endocrinology Source Type: research

Optimizing waist circumference cut-points for the metabolic syndrome in a South African cohort at 3-year follow-up: the SABPA prospective cohort
(Source: Endocrine)
Source: Endocrine - November 21, 2014 Category: Endocrinology Source Type: research

Psoriasis Is a Systemic Disease with Multiple Cardiovascular and Metabolic Comorbidities
This article summarizes the current literature on cardiovascular and metabolic comorbidities in psoriasis, identifies research gaps, and suggests management strategies to reduce cardiovascular risk in patients with moderate to severe psoriasis. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - November 21, 2014 Category: Dermatology Authors: Caitriona Ryan, Brian Kirby Source Type: research

Pentoxifylline alleviates hypertension in metabolic syndrome: effect on low-grade inflammation and angiotensin system
Conclusion Pentoxifylline directly alleviated hypertension in metabolic syndrome rats, at least in part, via amelioration of low-grade inflammation and inhibition of angiotensin system. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 21, 2014 Category: Endocrinology Source Type: research

[Metabolism] Making the brain promote fat loss in mice
Obesity is a growing global problem associated with diabetes and metabolic syndrome. Signals from the brain regulate whole body metabolism and can trigger adipose tissue to burn fat. – [Read More] (Source: This Week in Science)
Source: This Week in Science - November 21, 2014 Category: Science Authors: Wei Wong Tags: Metabolism Source Type: research

Risk of non‐alcoholic fatty liver disease in patients with psoriasis: a systematic review and meta‐analysis
ConclusionCase–control studies support an association between psoriasis and NAFLD. Screening of NAFLD in this group of patients may be warranted. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - November 21, 2014 Category: Dermatology Authors: R. Candia, A. Ruiz, R. Torres‐Robles, N. Chávez‐Tapia, N. Méndez‐Sánchez, M. Arrese Tags: Review Article Source Type: research

Leptin Improves Fatty Liver Independently of Insulin Sensitization and Appetite Suppression in Hepatocyte-Specific Pten-Deficient Mice with Insulin Hypersensitivity
Horm Metab ResDOI: 10.1055/s-0034-1395531Nonalcoholic fatty liver disease (NAFLD) is recognized as the hepatic component of the metabolic syndrome. Although NAFLD is a major cause of cirrhosis and cancer of the liver of unknown cause, no established pharmacological treatment for NAFLD has been established yet. It has been reported that leptin treatment improved fatty liver dramatically as well as insulin resistance and hyperphagia in patients with lipodystrophy. However, it is unclear whether leptin improves fatty liver independently of these metabolic improvements. We investigated the liver effect of leptin independently ...
Source: Hormone and Metabolic Research - November 21, 2014 Category: Endocrinology Authors: Yamamoto-Kataoka, S.Ebihara, K.Aizawa-Abe, M.Nishio, M.Kusakabe, T.Yamamoto, Y.Aotani, D.Sakai, T.Zhao, M.Ebihara, C.Gumbilai, V. M. J.Hosoda, K.Suzuki, A.Nakao, K. Tags: Endocrine Research Source Type: research

Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet
In this study, we fed Bama minipigs a high-fat, high-sucrose diet (HFHSD) for 23 months. The pigs exhibited characteristics of metabolic syndrome and developed steatohepatitis with greatly increased numbers of inflammatory cells, such as lymphocytes (2.27-fold, P (Source: PLoS One)
Source: PLoS One - November 21, 2014 Category: Biomedical Science Authors: Jihan Xia et al. Source Type: research

Recent Patents on Novel MCH1 Receptor Antagonists as Potential Anti-Obesity Drugs.
Authors: Szalai KK, Beke G, Eles J, Kitka T, Nagy J, Farkas S, Boros A Abstract Today, the "obesity pandemic" is one of the biggest health issues around the world. As hypothalamic neuropeptide melanin-concentrating hormone (MCH) is one of the most potent central stimulators of feeding, regulating energy balance, inhibition of its receptor, melanin concentrating hormone receptor-1 (MCHR1), has attracted considerable attention during the last decade. There are is now a great selection of known MCHR1 antagonists that provide clues to for the development of new structures with high potency and good pharmacokinetic prof...
Source: Recent Patents on CNS Drug Discovery - November 20, 2014 Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research

Targets of anti-glucocorticoid therapy for stress-related diseases.
Authors: Martocchia A, Stefanelli M, Falaschi GM, Toussan L, Rocchietti March M, Raja S, Romano G, Falaschi P Abstract The stress response during chronic conditions increases vulnerability to diseases through the activation of adaptive systems, in particular, the hypothalamus-pituitary-adrenal (HPA) axis. Dysregulation in HPA activity (central and peripheral) has been reported in chronic diseases, like metabolic syndrome, type-2 diabetes mellitus, atherosclerosis-related disease, essential hypertension, dementia, depression, particularly during comorbid conditions. Different targets of anti-glucocorticoid treatment...
Source: Recent Patents on CNS Drug Discovery - November 20, 2014 Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research

Assessment of Obesity and Cardiovascular Risk in South Asians
Abstract In 2010, coronary disease was officially recognized as the number one cause of death in India. However, it has long been known that the prevalence of cardiovascular disease in South Asians is significantly higher than in other ethnic groups. More than 60 % of the world’s coronary disease burden resides in South Asia, and the first coronary event occurs, on average, over 10 years earlier in South Asians than in other ethnicities. This higher coronary event rate is attributed to both the earlier onset and high incidence of several coronary risk factors, such as obesity/metabolic syndrome, dyslipidemia,...
Source: Current Cardiovascular Risk Reports - November 20, 2014 Category: Cardiology Source Type: research

Effects of a training program at the crossover point on the cluster of metabolic abnormalities and cardiovascular risk factors
Publication date: Available online 18 November 2014 Source:Journal of Exercise Science & Fitness Author(s): Jérémy B. Coquart , Guillaume Boitel , Benoît Borel , Régis Matran , Claire Mounier-Vehier , Murielle Garcin The present study examined the effects of a training program at a special exercise intensity—the crossover point of substrate utilization (COP)—on the metabolic abnormalities and cardiovascular risk factors in obese women with metabolic syndrome (MetS). Eighteen postmenopausal obese women with MetS (age, 54.8 ± 8.4 years; height, 160 ± 6 cm) followed a 12-week training program consisti...
Source: Journal of Exercise Science and Fitness - November 20, 2014 Category: Sports Medicine Source Type: research

Diversity of Apolipoprotein E genetic polymorphism significance on cardiovascular risk is determined by the presence of Metabolic Syndrome among hypertensive patients
Conclusions: The results presented demonstrate that the association between ApoE gene and CVD may be modulated by the presence of MetS, with an increased CV burden observed among E4 allele carriers with the syndrome. On the opposite way, E4 allele carriers without visceral obesity had lesser prevalence of CVD. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - November 20, 2014 Category: Lipidology Authors: Andrei TeixeiraMauro MarrocosBeata QuintoMaria DalboniCassio RodriguesSilmara de Melo CarmonaMariana KuniyoshiMarcelo Batista Source Type: research

Significance of nitric oxide synthases: lessons from triple nitric oxide synthases null mice
Publication date: Available online 18 November 2014 Source:Journal of Pharmacological Sciences Author(s): Masato Tsutsui , Akihide Tanimoto , Masahito Tamura , Hiroshi Mukae , Nobuyuki Yanagihara , Hiroaki Shimokawa , Yutaka Otsuji Nitric oxide (NO) is synthesized by three distinct NO synthases (neuronal, inducible, and endothelial NOSs), all of which are expressed in almost all tissues and organs in humans. The regulatory roles of NOSs in vivo have been investigated in pharmacological studies with non-selective NOS inhibitors. However, because the specificity of the inhibitors continues to be an issue of debate, the aut...
Source: Journal of Pharmacological Sciences - November 20, 2014 Category: Drugs & Pharmacology Source Type: research

Individual Risk Factors of the Metabolic Syndrome in Adult Patients with Growth Hormone Deficiency – A Cross-sectional Case-control Study
Conclusions: Although GHDA was associated with the development of visceral obesity and dyslipidemia, these adverse cardiovascular risk factors did not determine a higher prevalence of the MS in Bulgarian GHD patients compared to control subjects. Furthermore, the individual risk factors of the MS did not significantly differ between patients with MS from both groups.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 20, 2014 Category: Endocrinology Authors: Uzunova, I.Kirilov, G.Zacharieva, S.Shinkov, A.Borissova, A.-M.Kalinov, K. Tags: Article Source Type: research

Positive effects of Nordic Walking on anthropometric and metabolic variables in women with type 2 diabetes mellitus
Conclusions Our study shows that a supervised Nordic Walking program determines a significant improvement in metabolic and anthropometric parameters in women with type 2 diabetes. (Source: Science and Sports)
Source: Science and Sports - November 20, 2014 Category: Sports Medicine Source Type: research

Improvement in Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome in Adolescents Undergoing Bariatric Surgery
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children. It is linked to obesity and the Metabolic Syndrome (MS), pre-disposing to future cirrhosis. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 20, 2014 Category: Surgery Authors: John J. Loy, Heekoung A. Youn, Bradley Schwack, Marina Kurian, Christine Ren Fielding, George A. Fielding Tags: Improved Metabolic Parameters Achievable Source Type: research

Effects of dairy protein and fat on the metabolic syndrome and type 2 diabetes.
Authors: Bjørnshave A, Hermansen K Abstract The incidence of the metabolic syndrome (MetS) and type 2 diabetes (T2D) is increasing worldwide. Evidence supports a negative relationship between the consumption of dairy products and risk of MetS and T2D. Dairy proteins are known to have a directly beneficial effect on hypertension, dyslipidemia, and hyperglycemia, but a detailed understanding of the underlying mechanisms is missing. It has been confirmed by observations that the insulinotropic effect of dairy proteins is associated with the amino acid composition; in particular branched-chain amino acids (BCAA) seem ...
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Low total testosterone levels are associated with the metabolic syndrome in elderly men: the role of body weight, lipids, insulin resistance, and inflammation; the Ikaria study.
CONCLUSIONS: In elderly men, low serum testosterone was associated with MetS. Lipids, BMI, inflammation, and insulin resistance levels seem to explain this relationship, suggesting a potential mediating effect. This finding may support a research hypothesis relating serum testosterone to cardiovascular disease, which requires further research. PMID: 24172696 [PubMed - indexed for MEDLINE] (Source: Review of Diabetic Studies)
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Evaluation of the Finnish Diabetes Risk Score (FINDRISC) as a screening tool for the metabolic syndrome.
CONCLUSION: The results of this study suggest that FINDRISC can be applied to detect MetS in a high-risk population. PMID: 24841881 [PubMed - in process] (Source: Review of Diabetic Studies)
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Lipid accumulation product and 25-OH-vitamin D deficiency in type 2 diabetes.
CONCLUSIONS: In the presence of excess weight, subjects with and without T2D frequently feature low 25(OH)D levels. Subjects with higher LAP exhibit a high risk of 25(OH)D deficiency, suggesting that dysfunctional adiposity is a worsening factor for vitamin D hypovitaminosis. PMID: 24841878 [PubMed - in process] (Source: Review of Diabetic Studies)
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Telephone counseling intervention improves dietary habits and metabolic parameters of patients with the metabolic syndrome: a randomized controlled trial.
CONCLUSIONS: Telephone counseling is an effective way to implement behavioral counseling to improve lifestyle habits in MetS patients. PMID: 22972443 [PubMed - indexed for MEDLINE] (Source: Review of Diabetic Studies)
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Peptides and their potential role in the treatment of diabetes and obesity.
Authors: Greenwood HC, Bloom SR, Murphy KG Abstract It is estimated that 347 million people worldwide have diabetes and that over 1.5 billion adults worldwide are overweight. Predictions suggest these rates are increasing. Diabetes is a common complication in overweight and obese subjects, and in 2004, an estimated 3.4 million people died from consequences of high blood sugar. Thus, there is great interest in revealing the physiological systems that regulate body weight and blood sugar. Several peptidergic systems within the central nervous system and the periphery regulate energy homeostasis. A number of these sys...
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

The frequency of prediabetes and contributing factors in patients with chronic kidney disease.
CONCLUSIONS: Prediabetes is a frequent condition in CKD patients. Also, hypertriglyceridemia and hypertension are more prevalent in prediabetic CKD patients than in non-diabetic CKD patients. PMID: 22189551 [PubMed - indexed for MEDLINE] (Source: Review of Diabetic Studies)
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index.
CONCLUSIONS: We observed a significantly higher BMI in women, and GA or AA carriers of -11391G/A polymorphism. Also, there was a significantly lower WC in females and GG carriers of +45T/G. These results point to a gender-specific impact of the studied genotypes on BMI and WC. PMID: 21409316 [PubMed - indexed for MEDLINE] (Source: Review of Diabetic Studies)
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Health care access and prevalence of the metabolic syndrome among elders living in high-altitude areas of the Mediterranean islands: the MEDIS study.
CONCLUSIONS: A considerable proportion of mountainous living elderly had the metabolic syndrome. Public health actions need to be taken to reduce the burden of cardiometabolic disorders by enabling better access to health care, especially in remote mountainous rural areas. PMID: 22580728 [PubMed - indexed for MEDLINE] (Source: Review of Diabetic Studies)
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Metabolic syndrome-related hepatocellular carcinoma treated by volumetric modulated arc therapy.
Authors: Klein J, Dawson LA, Tran TH, Adeyi O, Purdie T, Sherman M, Brade A Abstract Hepatocellular carcinoma (hcc) is a leading cause of cancer mortality, and its incidence is increasing in developed countries. Risk factors include cirrhosis from viral hepatitis or alcohol abuse. Metabolic syndrome is a newly recognized, but important, risk factor that is likely contributing to the increased incidence of hcc. Surgery is the therapy of choice for hcc, but local therapies are often contraindicated, usually because of advanced disease or comorbid conditions such as cardiac disease (which is associated with metabolic ...
Source: Current Oncology - November 19, 2014 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Cardiovascular risk factors in the antiphospholipid syndrome.
Authors: da Silva FF, Levy RA, de Carvalho JF Abstract A major cause of morbidity and mortality in the context of the antiphospholipid syndrome (APS) is the occurrence of thrombotic events. Besides the pathogenic roles of antiphospholipid antibodies (aPL), other risk factors and medical conditions, which are conditions for traditional risk of an individual without the APS, can coexist in this patient, raising their risk of developing thrombosis. Therefore, the clinical and laboratory investigation of comorbidities known to increase cardiovascular risk in patients with antiphospholipid antibody syndrome is crucial f...
Source: Journal of Immunology Research - November 19, 2014 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Food Intake Does Not Differ between Obese Women Who Are Metabolically Healthy or Abnormal [Nutritional Epidemiology]
Conclusions: Healthy obesity was not associated with a healthier diet. Prospective studies on relations of dietary patterns, which may be a better indicator of usual diet, with the phenotype would be beneficial. (Source: Journal of Nutrition)
Source: Journal of Nutrition - November 19, 2014 Category: Nutrition Authors: Kimokoti, R. W., Judd, S. E., Shikany, J. M., Newby, P. Tags: Nutritional Epidemiology Source Type: research

Metabolic syndrome and infertility in men
Publication date: Available online 24 October 2014 Source:Best Practice & Research Clinical Obstetrics & Gynaecology Author(s): Christopher D. Morrison , Robert E. Brannigan Metabolic syndrome is compilation of symptoms including central obesity, insulin resistance, dyslipidemia and hypertension. Initially used to predict cardiovascular disease, it is now clear that the molecular and physiologic abnormalities seen in metabolic syndrome extend well beyond the cardiovascular system. Growing evidence has linked metabolic syndrome and its individual symptoms to the increasing prevalence of male infertility. T...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

Metabolic disorder of pregnancy (understanding pathophysiology of diabetes and preeclampsia)
Publication date: Available online 16 October 2014 Source:Best Practice & Research Clinical Obstetrics & Gynaecology Author(s): Liat Salzer , Kinneret Tenenbaum-Gavish , Moshe Hod The role of insulin resistance in human disease is implicated in the pathogenesis of some of the chief western chronic diseases: ischemic heart disease, type 2 diabetes mellitus, and essential hypertension. The occurrence of these diseases, alongside obesity, is termed the metabolic syndrome. Pregnancy is normally attended by progressive insulin resistance that begins near midpregnancy and progresses through the third trimester ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

Diffuse idiopathic skeletal hyperostosis as a cause of dysphagia in a young patient with metabolic syndrome
(Source: PM and R)
Source: PM and R - November 19, 2014 Category: Rehabilitation Authors: Mehmet Agirman, Oguz Durmus, Tugrul Ormeci, Bahri Teker, Engin Cakar Source Type: research

Metabolic syndrome related health inequalities in Korean elderly: Korean National Health and Nutrition Examination Survey (KNHAES)
This study aimed to group metabolic risk factors and to examine the associations between groups of health living conditions and metabolic syndrome using data from the Korean National Health Examination and Nutritional Assessment (KNHANES). A total of 1,435 subjects aged over 65?years old with both biochemical and dietary data information were obtained from the 4th and 5th KNHANES (2007?2012). Using stratified and multistage probability sample data, five components of metabolic syndrome were adopted to identify health inequalities. Our findings show that groups of health living conditions such as dietary pattern, body image...
Source: International Journal for Equity in Health - November 19, 2014 Category: Global & Universal Authors: Hak-Seon Kim Source Type: research

Serum Lipids and the Risk of Gastrointestinal Malignancies in the Swedish AMORIS Study.
Conclusion. The persistent link between TC and rectal cancer risk as well as between TG and oesophageal and colon cancer risk in normoglycaemic individuals may imply their substantiality in gastrointestinal carcinogenesis. PMID: 22969802 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - November 18, 2014 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Weight loss reduces serum monocyte chemoattractant protein-1 concentrations in association with improvements in renal injury in obese men with metabolic syndrome
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 18, 2014 Category: Laboratory Medicine Source Type: research

The 13C-glucose breath test is a valid non-invasive screening tool to identify metabolic syndrome in adolescents
Journal Name: Clinical Chemistry and Laboratory MedicineIssue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 18, 2014 Category: Laboratory Medicine Source Type: research

The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy
Publication date: August 2014 Source:Molecular and Cellular Probes, Volume 28, Issue 4 Author(s): Rosario Liguori , Giuseppe Labruna , Andreina Alfieri , Domenico Martone , Eduardo Farinaro , Franco Contaldo , Lucia Sacchetti , Fabrizio Pasanisi , Pasqualina Buono Gene variants in MC4R, SIRT1 and FTO are associated with severe obesity and metabolic impairment in Caucasians. We investigated whether common variants in these genes are associated with metabolic syndrome (MetS) in a large group of morbidly obese young adults from southern Italy. One thousand morbidly obese subjects (62% women, mean body mass index 46.5 kg/m2...
Source: Molecular and Cellular Probes - November 18, 2014 Category: Molecular Biology Source Type: research