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Influence of Aerobic Training and Detraining on Serum BDNF, Insulin Resistance, and Metabolic Risk Factors in Middle-Aged Men Diagnosed With Metabolic Syndrome
Conclusions: Improved metabolic risk factors along with decreased serum BDNF in response to aerobic training and the opposite direction during the detraining emphasize the importance of physical activity in the treatment of MetS and prevention of related diseases. (Source: Clinical Journal of Sport Medicine)
Source: Clinical Journal of Sport Medicine - October 31, 2014 Category: Sports Medicine Tags: Original Research Source Type: research

[Special Issue Review] Human cognitive aging: Corriger la fortune?
Human cognitive aging differs between and is malleable within individuals. In the absence of a strong genetic program, it is open to a host of hazards, such as vascular conditions, metabolic syndrome, and chronic stress, but also open to protective and enhancing factors, such as experience-dependent cognitive plasticity. Longitudinal studies suggest that leading an intellectually challenging, physically active, and socially engaged life may mitigate losses and consolidate gains. Interventions help to identify contexts and mechanisms of successful cognitive aging and give science and society a hint about what would be possi...
Source: Science: Current Issue - October 31, 2014 Category: Science Authors: Ulman Lindenberger Source Type: research

Effects of Metabolic Syndrome and Findings from Baseline Colonoscopies on Occurrence of Colorectal Neoplasms
Metabolic syndrome is associated with increased risk of colorectal neoplasm, but little is known about its effects on the occurrence of neoplasm after colonoscopy. We investigated the effects of metabolic syndrome on the risk of advanced neoplasm after colonoscopy. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 29, 2014 Category: Gastroenterology Authors: Han-Mo Chiu, Yi-Chia Lee, Chia-Hung Tu, Li-Chun Chang, Wen-Feng Hsu, Chu-Kuang Chou, Kun-Feng Tsai, Jin-Tung Liang, Chia-Tung Shun, Ming-Shiang Wu Source Type: research

Soy provides modest benefits on endothelial function without affecting inflammatory biomarkers in adults at cardiometabolic risk
Conclusions: Soy nuts when added to a usual diet for one month provide some benefit on arterial stiffness in adults at cardiometabolic risk.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - October 29, 2014 Category: Nutrition Authors: Elizabeth J. Reverri, Colette D. LaSalle, Adrian A. Franke, Francene M. Steinberg Tags: Research Article Source Type: research

Impact of a lifestyle program on vascular insulin resistance in metabolic syndrome subjects: the Resolve study.
Conclusions: The local vasodilatory effects to insulin and its overall flowmotion are impaired in MetS subjects in relation to inflammation. The lifestyle intervention reversed this insulin-induced vascular dysfunction in parallel to decreased inflammation level. PMID: 25353072 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 29, 2014 Category: Endocrinology Authors: Vinet A, Obert P, Dutheil F, Diagne L, Chapier R, Lesourd B, Courteix D, Walther G Tags: J Clin Endocrinol Metab Source Type: research

Protective effect of thymoquinone against high-fructose diet-induced metabolic syndrome in rats
Conclusions This study demonstrates protective effect of TQ against HFD-induced MetS on rats which might have been mediated via PPAR mechanism. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - October 28, 2014 Category: Nutrition Source Type: research

Pentoxifylline in the Management of Metabolic Syndrome and Chronic Hepatitis C
Metabolic syndrome (MS) and chronic hepatitis C (CHC) are prevalent diseases with many serious and fatal outcomes. Many of these outcomes are attributed to increased level of TNF-α which causes insulin resistance (IR), liver damage, increased incidence and mortality of hepatorenal syndrome (HRS), liver fibrosis and nonalcoholic steatohepatitis (NASH). So, an approach that depends on reducing the TNF-α levels is considered a reasonable method to help treat these conditions. Putting together the available data in the previous literature about pentoxifylline (PTX) would highly suggest that this drug is perfect for managing ...
Source: Medical Hypotheses - October 28, 2014 Category: Biomedical Science Authors: Amr Hany Metwally Source Type: research

Effects of an Internet-based lifestyle intervention on cardio-metabolic risks and stress in Korean workers with metabolic syndrome: A controlled trial
This research was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF), which is funded by the Korean Ministry of Education, Science and Technology (MEST; grant number 2010-0015339) and was partly supported by a grant in 2012 from Department of Nursing, Graduate School, Ajou University. (Source: Patient Education and Counseling)
Source: Patient Education and Counseling - October 28, 2014 Category: Global & Universal Authors: Chun-Ja Kim, Elizabeth A. Schlenk, Se-Won Kang, Jae-Bum Park Source Type: research

Normal Development of Conduction Velocity in Rats is Prevented by Fructose-Fat Feeding
Diabetes and metabolic syndrome causes cardiac electrical abnormalities that increase the risk for arrhythmias and sudden death. We have established fructose-fat fed rats (FFFRs) as a prediabetic model, which after 6 weeks of feeding exhibit intramyocardial lipid accumulation, decreased cardiac conduction velocity (CV), and increased risk of ventricular fibrillation following ischemia–reperfusion. CV slowing was not explained by changes in Na+, K+, or gap junction channel function; however, CV may be altered by a depolarized resting membrane potential (RMP). (Source: Heart Rhythm)
Source: Heart Rhythm - October 27, 2014 Category: Cardiology Authors: C.F. Jensen, L. Skibsbye, E.D. Bartels, L.B. Nielsen, N. Holstein-Rathlou, T. Jespersen, L.N. Axelsen, M.S. Nielsen Tags: Basic Science Source Type: research

Higher serum carotenoid concentrations associated with a lower prevalence of the metabolic syndrome in middle-aged and elderly Chinese adults.
Abstract The association between serum carotenoids and the metabolic syndrome (MetS) remains uncertain, and little is known about this relationship in the Chinese population. The present study examined the association between serum carotenoid concentrations and the MetS in Chinese adults. We conducted a community-based cross-sectional study in which 2148 subjects (1547 women and 601 men) aged 50-75 years were recruited in urban Guangzhou, China. Dietary data and other covariates were collected during face-to-face interviews. Blood pressure, waist circumference, blood lipids, glucose and serum carotenoids (α-, β-c...
Source: The British Journal of Nutrition - October 27, 2014 Category: Nutrition Authors: Liu J, Shi WQ, Cao Y, He LP, Guan K, Ling WH, Chen YM Tags: Br J Nutr Source Type: research

Compartmental neck fat accumulation and its relation to cardiovascular risk and metabolic syndrome.
CONCLUSIONS: Neck fat compartments expand differently with increasing adiposity, correlate with CVD risk factors, and are associated with metabolic syndrome, most notably NATpost and NATsc in women. Although neck circumference remains an important method to assess metabolic risk, cross-sectional NAT assessment provides further insight into fat accumulation in the neck. This trial was registered at clinicaltrials.gov as NCT02205021. PMID: 25332322 [PubMed - in process] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - October 26, 2014 Category: Nutrition Authors: Torriani M, Gill CM, Daley S, Oliveira AL, Azevedo DC, Bredella MA Tags: Am J Clin Nutr Source Type: research

Applicability of the visceral adiposity index (vai) in predicting components of metabolic syndrome in young adults.
Conclusion: VAI presented an association to MS components in males and females with an increased risk of abdominal obesity, hipertriglyceridemia, and low HDL-c, proving to be a good MS components predictor even among healthy young adults. PMID: 25335666 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - October 26, 2014 Category: Nutrition Authors: Schuster J, Vogel P, Eckhardt C, Dal Bosco Morelo S Tags: Nutr Hosp Source Type: research

[Obesity associated metabolic impairment is evident at early ages: spanish collaborative study].
The objectives of this study are to provide a description of the demographic, anthropometric characteristics and metabolic abnormalities in children with early-onset (< 10 years) and of very-early-onset obesity (< 5 years). We also evaluate the diagnostic ability using the definition of metabolic syndrome (MS) according to different criteria. METHODS: It is a retrospective, case-control, cross-sectional, multicenter study. A total of 10 Pediatric Endocrinology Units in different Spanish hospitals were involved. A group of 469 children with early-onset obesity and another group of 30 children with very early-onset...
Source: Nutricion Hospitalaria - October 26, 2014 Category: Nutrition Authors: Martos-Moreno GÁ, Gil-Campos M, Bueno G, Bahillo P, Bernal S, Feliu A, Lechuga-Sancho AM, Palomo E, Ruiz R, Vela A Tags: Nutr Hosp Source Type: research

CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits
Conclusions: Overall, we demonstrate that SNPs supporting cardiometabolic GxE interactions often exhibit transcriptional effects or are under positive selection. Still, not all such SNPs can be assigned potential functional or regulatory roles often because data are lacking in specific cell types or from treatments that approximate the environmental factor of the GxE. With research on metabolic related complex disease risk embarking on genome-wide GxE interaction tests, CardioGxE will be a useful resource. (Source: BioData Mining)
Source: BioData Mining - October 26, 2014 Category: Bioinformatics Authors: Laurence ParnellBritt BlokkerHassan DashtiPaula-Dene NesbethBrittany CooperYiyi MaYu-Chi LeeRuixue HouChao-Qiang LaiKris RichardsonJosé Ordovás Source Type: research

Fat sensing and metabolic syndrome
Abstract Overconsumption of dietary fat contributes to the development of obesity and metabolic syndrome. Recent evidence suggests that high dietary fat may promote these metabolic states not only by providing calories but also by inducing impaired control of energy balance. In normal metabolic states, fat interacts with various organs or receptors to generate signals for the regulation of energy balance. Many of these interactions are impaired by high-fat diets or in obesity, contributing to the development or maintenance of obesity. These impairments may arise largely from fundamental alterations in the hypothal...
Source: Reviews in Endocrine and Metabolic Disorders - October 26, 2014 Category: Endocrinology Source Type: research

Adipocyte dysfunction, inflammation and metabolic syndrome
Abstract Obesity is frequently associated with chronic inflammation, metabolic and vascular alterations which predispose to the development of the Metabolic Syndrome (MetS). However, the individual obesity-related risk for the MetS is not determined by increased fat mass alone. Heterogeneity of body composition, fat distribution and adipose tissue (AT) function may underly the variable risk to develop metabolic and cardiovascular diseases associated with increased body fat mass. Importantly, an inability to increase AT mass by adipocyte hyperplasia may lead to adipocyte hypertrophy and could induce dysfunction of ...
Source: Reviews in Endocrine and Metabolic Disorders - October 26, 2014 Category: Endocrinology Source Type: research

Serum ferritin levels and the development of metabolic syndrome and its components: a 6.5-year follow-up study
Background: The aim of this study was to investigate the relationship between changes in serum ferritin concentrations and the development of metabolic syndrome (MetS) and its components over a 6.5 year follow-up period in Finnish adults. Methods: Adults born in Pieksamaki, Finland, in 1942, 1947, 1952, 1957, and 1962 (n =1294) were invited to health checkups between 1997 and 1998 and 2003 and 2004. All of the required variables for both checkups were available from 691 (53%) subjects (289 men and 402 women). MetS was defined by the National Cholesterol Education Program criteria. Results: During the 6.5-year follow-up per...
Source: Epidemiologic Perspectives and Innovations - October 26, 2014 Category: Epidemiology Authors: Päivi HämäläinenJuha SaltevoHannu KautiainenPekka MäntyselkäMauno Vanhala Source Type: research

Adipocyte dysfunction, inflammation and metabolic syndrome.
Abstract Obesity is frequently associated with chronic inflammation, metabolic and vascular alterations which predispose to the development of the Metabolic Syndrome (MetS). However, the individual obesity-related risk for the MetS is not determined by increased fat mass alone. Heterogeneity of body composition, fat distribution and adipose tissue (AT) function may underly the variable risk to develop metabolic and cardiovascular diseases associated with increased body fat mass. Importantly, an inability to increase AT mass by adipocyte hyperplasia may lead to adipocyte hypertrophy and could induce dysfunction of a...
Source: ENDOCR REV - October 26, 2014 Category: Endocrinology Authors: Klöting N, Blüher M Tags: Rev Endocr Metab Disord Source Type: research

Fat sensing and metabolic syndrome.
Abstract Overconsumption of dietary fat contributes to the development of obesity and metabolic syndrome. Recent evidence suggests that high dietary fat may promote these metabolic states not only by providing calories but also by inducing impaired control of energy balance. In normal metabolic states, fat interacts with various organs or receptors to generate signals for the regulation of energy balance. Many of these interactions are impaired by high-fat diets or in obesity, contributing to the development or maintenance of obesity. These impairments may arise largely from fundamental alterations in the hypothala...
Source: ENDOCR REV - October 26, 2014 Category: Endocrinology Authors: Youn JH Tags: Rev Endocr Metab Disord Source Type: research

Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin d in mice fed a high-fat diet.
Abstract The role of vitamin D in curtailing the development of obesity and comorbidities such as the metabolic syndrome (MetS) and type 2 diabetes has received much attention recently. However, clinical trials have failed to conclusively demonstrate the benefits of vitamin D supplementation. In most studies, serum 25-hydroxyvitamin D [25(OH)D] decreases with increasing BMI above normal weight. These low 25(OH)D levels may also be a proxy for reduced exposure to sunlight-derived ultraviolet radiation (UVR). Here we investigate whether UVR and/or vitamin D supplementation modifies the development of obesity and type...
Source: Diabetes - October 25, 2014 Category: Endocrinology Authors: Geldenhuys S, Hart PH, Endersby R, Jacoby P, Feelisch M, Weller RB, Matthews V, Gorman S Tags: Diabetes Source Type: research

RESISTANCE TRAINING AND METABOLIC SYNDROME: Muscles Do Matter
LEARNING OBJECTIVETo provide an overview of metabolic syndrome and discuss how resistance training can help prevent or manage metabolic syndrome. Most importantly, we will give scientifically supported resistance training programming recommendations for persons with metabolic syndrome. (Source: ACSMs Health and Fitness Journal)
Source: ACSMs Health and Fitness Journal - October 25, 2014 Category: Sports Medicine Tags: Features Source Type: research

Apolipoprotein e Gene Polymorphisms in Relation to Chronic Periodontitis, Periodontopathic Bacteria and Lipid Levels
Periodontitis is chronic infectious disease characterized by a progressive inflammatory response to bacteria in dental plaque that finally results in periodontal tissue destruction and eventual tooth loss. Evidence suggests that the local inflammation/infection triggers a systemic host response associated with increased risk for cardiovascular diseases and atherosclerosis.1 Periodontitis has also been associated with glucose intolerance2, endothelial dysfunction3, and dyslipidemia and metabolic syndrome. (Source: Archives of Oral Biology)
Source: Archives of Oral Biology - October 25, 2014 Category: Dentistry Authors: Petra Borilova Linhartova, Jirina Bartova, Hana Poskerova, Jan Machal, Jan Vokurka, Antonin Fassmann, Lydie Izakovicova Holla Source Type: research

Medical Morbidities in Endometrial Cancer Patients
ConclusionThis was the first large analysis in South-East Asia showing common incidence of medical morbidities in EMC patients. One or more components of metabolic syndrome were the most common. Some medical illnesses were the causes of death. Comprehensive and continual medical care for EMC patients is important. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 24, 2014 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Metabolic Syndrome and Lower Urinary Tract Symptoms in Patients With Benign Prostatic Enlargement: A Possible Link to Storage Symptoms
To evaluate the association between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) in patients with benign prostatic enlargement (BPE). (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Cosimo De Nunzio, Luca Cindolo, Mauro Gacci, Fabrizio Pellegrini, Marco Carini, Riccardo Lombardo, Giorgio Franco, Andrea Tubaro Tags: Prostatic Diseases and Male Voiding Dysfunction Source Type: research

A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome
Conclusions This review suggests a potential role of N. sativa and TQ in the management of metabolic syndrome, however more studies should be conducted to evaluate their effectiveness. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 24, 2014 Category: Endocrinology Source Type: research

Metabolic syndrome and infertility in men
Metabolic syndrome is compilation of symptoms including central obesity, insulin resistance, dyslipidemia and hypertension. Initially used to predict cardiovascular disease, it is now clear that the molecular and physiologic abnormalities seen in metabolic syndrome extend well beyond the cardiovascular system. Growing evidence has linked metabolic syndrome and its individual symptoms to the increasing prevalence of male infertility. This manuscript will review the recent evidence connecting metabolic syndrome to male infertility as well as the underlying pathophysiology. (Source: Best Practice and Research. Clinical Obstet...
Source: Best Practice and Research. Clinical Obstetrics and Gynaecology - October 24, 2014 Category: OBGYN Authors: Christopher D. Morrison, Robert E. Brannigan Source Type: research

Pharmacological treatment and therapeutic perspectives of metabolic syndrome.
Abstract Metabolic syndrome is a disorder based on insulin resistance. Metabolic syndrome is diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal obesity, elevated blood pressures, elevated glucose, high triglycerides, and low high-density lipoprotein-cholesterol (HDL-C) levels. Clinical implication of metabolic syndrome is that it increases the risk of developing type 2 diabetes and cardiovascular diseases. Prevalence of the metabolic syndrome has increased globally, particularly in the last decade, to the point of being regarded as an epidemic. The prevalence of metabol...
Source: ENDOCR REV - October 24, 2014 Category: Endocrinology Authors: Lim S, Eckel RH Tags: Rev Endocr Metab Disord Source Type: research

Exercise therapy improves both mental and physical health in patients with major depression.
Conclusions: Physical therapists should be aware, that several characteristics of major depression (e.g. loss of interest, motivation and energy, generalised fatigue, a low self-worth and self-confidence, fear to move, and psychosomatic complaints) and physical health problems interfere with participation in exercise. Therefore, motivational strategies should be incorporated in exercise interventions to enhance the patients' motivation and adherence in exercise programs. Implications for Rehabilitation For mild to moderate depression, the effect of exercise may be comparable with antidepressant medication and psychotherapy...
Source: Disability and Rehabilitation - October 24, 2014 Category: Rehabilitation Authors: Knapen J, Vancampfort D, Moriën Y, Marchal Y Tags: Disabil Rehabil Source Type: research

Pharmacological treatment and therapeutic perspectives of metabolic syndrome
Abstract Metabolic syndrome is a disorder based on insulin resistance. Metabolic syndrome is diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal obesity, elevated blood pressures, elevated glucose, high triglycerides, and low high-density lipoprotein-cholesterol (HDL-C) levels. Clinical implication of metabolic syndrome is that it increases the risk of developing type 2 diabetes and cardiovascular diseases. Prevalence of the metabolic syndrome has increased globally, particularly in the last decade, to the point of being regarded as an epidemic. The prevalence of metabo...
Source: Reviews in Endocrine and Metabolic Disorders - October 23, 2014 Category: Endocrinology Source Type: research

Development of a Standardized Job Description for Healthcare Managers of Metabolic Syndrome Management Programs in Korean Community Health Centers
Conclusion A job description for healthcare managers may provide basic data essential for the development of a job training program for healthcare managers working in community health promotion programs. (Source: Asian Nursing Research)
Source: Asian Nursing Research - October 23, 2014 Category: Nursing Source Type: research

A Web-based Health Promotion Program for Patients with Metabolic Syndrome
Conclusions This study suggests that a web-based program is useful for patients with metabolic syndrome to improve physiologic parameters related to metabolic syndrome. The web-based program may be easily applicable to community as well as clinical setting. (Source: Asian Nursing Research)
Source: Asian Nursing Research - October 23, 2014 Category: Nursing Source Type: research

Influence of metabolic syndrome and its components on subclinical organ damage in hypertensive perimenopausal women
Conclusion In hypertensive perimenopausal women components of MS are stronger predictors of subclinical organ damage than MS itself. Left ventricular mass and hypertrophy are more strongly correlated with increasing body weight than with the presence of MS. MS, independently of BMI, influences the level of subclinical atherosclerosis in the study group. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 23, 2014 Category: Biomedical Science Source Type: research

Prognostic impact of metabolic syndrome in patients with chronic heart failure: Data from GISSI-HF trial
The adverse prognostic impact of metabolic syndrome (METS) in unselected populations and in patients with coronary heart disease has been previously shown. The aim of the current analysis was to evaluate the impact of METS on prognosis in chronic heart failure (HF). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - October 23, 2014 Category: Cardiology Authors: Pasquale Perrone-Filardi, Gianluigi Savarese, Marco Scarano, Riccardo Cavazzina, Bruno Trimarco, Sergio Minneci, Aldo Pietro Maggioni, Luigi Tavazzi, Gianni Tognoni, Roberto Marchioli Source Type: research

Association between metabolic syndrome, obesity, diabetes mellitus and oncological outcomes of bladder cancer: A systematic review
Abstract Metabolic syndrome is a cluster of several metabolic abnormalities, its prevalence is increasing worldwide. To summarize the most recent evidence regarding the relationship between metabolic syndrome, its components and the oncological outcomes in bladder cancer patients, a National Center for Biotechnology Information PubMed search for relevant articles either published or e‐published up to March 2014 was carried out by combining the following Patient population, Intervention, Comparison, Outcome terms: metabolic syndrome, obesity, body mass index, hyperglycemia, insulin resistance, diabetes, hypertension, dysl...
Source: International Journal of Urology - October 23, 2014 Category: Urology & Nephrology Authors: Francesco Cantiello, Antonio Cicione, Andrea Salonia, Riccardo Autorino, Cosimo De Nunzio, Alberto Briganti, Giorgio Gandaglia, Paolo Dell'Oglio, Paolo Capogrosso, Rocco Damiano Tags: Review Article Source Type: research

Hair cortisol and cortisol awakening response are associated with criteria of the metabolic syndrome in opposite directions
The metabolic syndrome (MetS) increases the risk of cardiovascular diseases and is defined by the International Diabetes Federation as central obesity and any two of the following criteria: raised fasting plasma glucose, raised triglycerides, reduced HDL cholesterol, and raised blood pressure (Alberti et al., 2005). Altered activity of the hypothalamus-pituitary-adrenal (HPA) axis and resulting changes of cortisol release have been suggested to play a role in the development of metabolic syndrome (Walker 2006). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 23, 2014 Category: Psychiatry Authors: Linn K. Kuehl, Kim Hinkelmann, Christoph Muhtz, Lucia Dettenborn, Katja Wingenfeld, Carsten Spitzer, Clemens Kirschbaum, Klaus Wiedemann, Christian Otte Tags: Short Communication Source Type: research

Influence of testosterone replacement therapy on metabolic disorders in male patients with type 2 diabetes mellitus and androgen deficiency
Conclusions Our study demonstrated that it is possible to break this metabolic vicious circle by raising testosterone levels in diabetic men with androgen deficiency. Re-instituting physiological levels of testosterone, as the study has shown, has an important role in reducing the prevalence of diabetic complications. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 23, 2014 Category: Research Source Type: research

DXA-measured visceral adipose tissue predicts impaired glucose tolerance and metabolic syndrome in obese Caucasian and African-American women
e & H J Silver (Source: European Journal of Clinical Nutrition)
Source: European Journal of Clinical Nutrition - October 22, 2014 Category: Nutrition Authors: X BiL SeaboltC ShibaoM BuchowskiH KangC D KeilR TyreeH J Silver Source Type: research

Metabolic syndrome in patients with prostate cancer undergoing androgen suppression
Conclusions Continuous AS therapy increases the prevalence of MS and especially waist circumference and hyperglycemia. Development of MS increases according to AS duration. (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - October 22, 2014 Category: Urology & Nephrology Source Type: research

Effort-reward imbalance is associated with the metabolic syndrome - findings from the Mannheim Industrial Cohort Study (MICS)
Job stress is a predictor of cardiovascular disease incidence and mortality and the metabolic syndrome (MetS) represents one of the key pathways potentially underlying those associations. Effort-reward imbalance (ERI) represents one of the most influential theoretical work stress models, but evidence on its relationship with MetS remains sparse and with only limited generalizability. We therefore aimed to determine this association in a large occupational sample with different occupational groups. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - October 22, 2014 Category: Cardiology Authors: Burkhard Schmidt, Jos A. Bosch, Marc N. Jarczok, Raphael M. Herr, Adrian Loerbroks, Annelies E.M. van Vianen, Joachim E. Fischer Source Type: research

The prevalence of metabolic syndrome in people with severe mental illness: a mediation analysis
Conclusions SMI remained prominent in increasing the likelihood of MetS in this low prevalence population, and putative determinants of MetS were common to people with SMI and to controls. Explanations for high MetS rates in SMI may lie in health behaviours other than smoking. (Source: Social Psychiatry and Psychiatric Epidemiology)
Source: Social Psychiatry and Psychiatric Epidemiology - October 21, 2014 Category: Psychiatry Source Type: research

A randomized controlled trial on a multicomponent intervention for overweight school-aged children - Copenhagen, Denmark
Background: Obesity amongst children is a growing problem worldwide. In contrast to adults, little is known on the effects of controlled weight loss on components of the metabolic syndrome in children. The primary aim of the study was to evaluate the effects of a 20-week exercise and diet guidance intervention on body mass index (BMI) in a group of overweight children. Our hypothesis was an observed reduction in BMI and secondarily in body fat content, insulin insensitivity, and other components of the metabolic syndrome in the intervention group. Methods: School children from Copenhagen were randomly allocated to an inter...
Source: BioMed Central - October 21, 2014 Category: Journals (General) Authors: Nina Majlund Harder-LauridsenNina Marie BirkMathias Ried-LarsenAnders JuulLars Bo AndersenBente Klarlund PedersenRikke Krogh-Madsen Source Type: research

Socioeconomic Status and Reduced Kidney Function in the Whitehall II Study: Role of Obesity and Metabolic Syndrome
Conclusions BMI and components of metabolic syndrome may explain up to a quarter of the association between low SES and decreased GFR, suggesting potential modifiable factors. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - October 21, 2014 Category: Urology & Nephrology Source Type: research

Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma
Conclusion The present data suggest that CP patients are less sensitive to the positive rhGH effects on lipid profile and BF % and more prone to insulin sensitivity worsening than NFPA patients, resulting in increased prevalence of MS in CP only. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 21, 2014 Category: Endocrinology Source Type: research

Liver resection and metabolic disorders: An undescribed mechanism leading to postoperative mortality.
CONCLUSION: As fibrosis was not present or marginal in liver specimens, the real cause of portal hypertension in patients with multiple metabolic disorders should be investigated with further studies. PMID: 25339832 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Zarzavadjian Le Bian A, Costi R, Sbai-Idrissi MS, Smadja C Tags: World J Gastroenterol Source Type: research

Non-alcoholic fatty liver disease: What has changed in the treatment since the beginning?
Abstract Non-alcoholic fatty liver disease (NAFLD) is an umbrella term to describe the entire spectrum of this common liver disease. In patients with NAFLD, especially those with non-alcoholic steatohepatitis (NASH), most often have one or more components of the metabolic syndrome, but this is not universal. Although most patients with NAFLD share many clinical features, only a subset of patients develops significant liver inflammation and progressive fibrosis. On the other hand, not all patients with NASH exhibit insulin resistance. NASH can be seen in patients who are lean and have no identifiable risk factors. M...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Baran B, Akyüz F Tags: World J Gastroenterol Source Type: research

Testosterone and benign prostatic hyperplasia.
Abstract The use of testosterone to treat the symptoms of late-onset hypogonadal men has increased recently due to patient and physician awareness. However, concerns regarding the effect of testosterone on the prostate, in particular any possible effect on the risk of prostate cancer have prompted further research in this regard. Surprisingly, numerous retrospective or small, randomized trials have pointed to a possible improvement in male lower urinary tract symptoms (LUTS) in patients treated with testosterone. The exact mechanism of this improvement is still debated but may have a close relationship to metabolic...
Source: Asian Journal of Andrology - October 21, 2014 Category: Urology & Nephrology Authors: Jarvis TR, Chughtai B, Kaplan SA Tags: Asian J Androl Source Type: research

Risk of incident diabetes in patients with gout: A cohort study
Conclusion: Gout was associated with an increased risk of developing DM compared with osteoarthritis after adjusting for potential confounders, and the risk associated with gout was higher among women than men. © 2014 American College of Rheumatology. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 20, 2014 Category: Rheumatology Authors: Seoyoung C. Kim, Jun Liu, Daniel H. Solomon Tags: Full Length Source Type: research

Metabolic syndrome‐like components and prostate cancer risk: results from the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study
ConclusionWhen biopsies are largely PSA level independent, men with an initial elevated PSA level and a previous negative biopsy, and multiple MetS‐like components were at an increased risk of high‐grade prostate cancer, suggesting the link between MetS‐like components and high‐grade prostate cancer is unrelated to a lowered PSA level. (Source: BJU International)
Source: BJU International - October 20, 2014 Category: Urology & Nephrology Authors: Katharine N. Sourbeer, Lauren E. Howard, Gerald L. Andriole, Daniel M. Moreira, Ramiro Castro‐Santamaria, Stephen J. Freedland, Adriana C. Vidal Tags: Urological Oncology Source Type: research

Peripheral Markers of Oxidative Stress and Antioxidative Defense in Euthymia of Bipolar Disorder-Gender and Obesity Effects
Oxidative and nitrosative stress are implicated in the pathogenesis of uni- and bipolar disorder. Herein we primarily sought to characterize markers of oxidative/nitrosative stress during euthymia in adults with bipolar disorder (BD). Oxidative markers were further evaluated in this BD sample as a function of whether excess weight and/or comorbid metabolic syndrome (MetS) was present. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 20, 2014 Category: Neurology Authors: S. Bengesser, N. Lackner, A. Birner, F.T. Fellendorf, M. Platzer, A. Mitteregger, R. Unterweger, B. Reininghaus, H. Mangge, S.J. Wallner-Liebmann, S. Zelzer, D. Fuchs, R.S. McIntyre, H.P. Kapfhammer, E.Z. Reininghaus Tags: Research report Source Type: research

Higher breakfast glycaemic load is associated with increased metabolic syndrome risk, including lower HDL-cholesterol concentrations and increased TAG concentrations, in adolescent girls.
Abstract Almost all previous studies examining the associations between glycaemic load (GL) and metabolic syndrome risk have used a daily GL value. The daily value does not distinguish between peaks of GL intake over the day, which may be more closely associated with the risk of the metabolic syndrome. The aim of the present study was to investigate the cross-sectional associations between daily and mealtime measures of GL and metabolic syndrome risk, including metabolic syndrome components, in adolescents. Adolescents participating in the 14-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study c...
Source: The British Journal of Nutrition - October 20, 2014 Category: Nutrition Authors: Nicholl A, du Heaume M, Mori TA, Beilin LJ, Oddy WH, Bremner AP, O'Sullivan TA Tags: Br J Nutr Source Type: research