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This page shows you the latest research publications in this category.

Severity of Metabolic Syndrome as a Predictor of Cardiovascular Disease Between Childhood and Adulthood The Princeton Lipid Research Cohort Study
The long-term ability of the metabolic syndrome (MetS) to predict cardiovascular disease (CVD) has been limited by the binary nature of traditional MetS criteria and by discrepancies among African Americans, who have low rates of MetS classification despite higher rates of death from CVD (1). We previously used confirmatory factor analysis to formulate MetS severity z-scores for adolescents (2) and adults (3) that place differential weights on the individual MetS components to account for variation in how MetS is manifest by sex and racial/ethnic group. Our goal was to assess the ability of these scores to determine long-...
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - August 3, 2015 Category: Radiology Source Type: research

The association between carbon and nitrogen stable isotope ratios of human hair and metabolic syndrome
Conclusions : The nitrogen, but not carbon, stable isotopic ratio of hair is independently associated with the presence of metabolic syndrome. The hair δ15N value might be a surrogate marker for clustering of risk factors in metabolic syndrome. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - August 2, 2015 Category: Laboratory Medicine Source Type: research

Nutrition‐based interventions to address metabolic syndrome in the Navajo: a systematic review
ConclusionsMultiple nutrition‐based interventions have been found to be effective in populations similar to the Navajo. Relevance to clinical practiceDevelopment of a strategy to address metabolic syndrome in the Navajo may involve aspects from multiple interventions to increase efficacy and maximise participation. (Source: Journal of Clinical Nursing)
Source: Journal of Clinical Nursing - August 2, 2015 Category: Nursing Authors: Lorenzo T Nava, Jenelle M Zambrano, Karen P Arviso, Denise Brochetti, Kathleen L Becker Tags: Review Source Type: research

Age-related changes in basal substrate oxidation and visceral adiposity and their association with metabolic syndrome
Conclusions Visceral adiposity remains one of the most important risk factors for cardiometabolic risk and is a significant predictor of MetSyn. Post-absorptive substrate oxidation does not appear to play a significant role in age-related changes in body composition and cardiometabolic risk, except for a correlation with triglyceride concentration. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - August 1, 2015 Category: Nutrition Source Type: research

Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome
Conclusion Results of the present study suggest that serum uric acid levels may contribute to the pathogenesis of MetS through a process mediated by arginase pathway, and serum arginase activity and nitrite and uric acid levels can be used as indicators of CVD in women with MetS. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - August 1, 2015 Category: Journals (General) Source Type: research

Risk for Nonalcoholic Fatty Liver Disease in Young Adults Born Preterm
Background: Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome. Accelerated catch-up in weight during infancy in subjects born at full term has been associated with increased risk for NAFLD in adulthood, but this association has not been studied in subjects born preterm. Methods: In 162 young adults born at a gestational age (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - August 1, 2015 Category: Endocrinology Source Type: research

TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adults
Abstract A circannual periodicity in thyrotropin (TSH) secretion has been reported but the causes of these phenomenon are still undefined. Vitamin D exerts a direct influence on pituitary axes including the hypothalamus–pituitary–thyroid axis. Aims of the present study were to investigate the presence of a seasonal variability of TSH secretion and to study the association between vitamin D status and TSH levels in a population of euthyroid adults. For this purpose, we recruited 294 euthyroid adults (M/F 133/161, 48.5 ± 12.4 years). Study participants underwent clinical examination and routine biochemi...
Source: Clinical and Experimental Medicine - August 1, 2015 Category: Research Source Type: research

Associations of the eNOS G894T gene polymorphism with target organ damage in children with newly diagnosed primary hypertension
Conclusion The eNOS T allele is not more prevalent among hypertensive children than among healthy ones, but it is associated with early vascular damage in children with PH, independent of metabolic abnormalities. No associations between the eNOS G894T polymorphism and metabolic abnormalities were found. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - July 31, 2015 Category: Urology & Nephrology Source Type: research

Effect of Weight Loss on Renal Function in Overweight and Obese Patients with Heart Failure
Estimations of glomerular filtration rate (GFR) has been studied in overweight and obese patients as a measure of renal function; however, the effect of a behavioral weight management intervention on GFR in overweight and obese patients with heart failure (HF) and type 2 diabetes mellitus (DM) or metabolic syndrome (MS) has not been studied. The purpose of the present study is to assess the short term effects of an energy restricted behavioral weight management program on renal function in this population. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 31, 2015 Category: Cardiology Authors: Marjan Motie, Lorraine Evangelista Tags: Epidemiology/Prevention I Source Type: research

Type 2 diabetes: ER stress modulator reverses diabetes
Nature Reviews Drug Discovery 14, 528 (2015). doi:10.1038/nrd4702 Author: Sarah Crunkhorn Chronic endoplasmic reticulum (ER) stress results in a defective unfolded protein response and is associated with a variety of pathologies, including metabolic syndrome. Using two novel high-throughput screening systems that measure ER chaperone availability and activity, Fu et al. identify the small molecule azoramide (Source: Nature Reviews Drug Discovery)
Source: Nature Reviews Drug Discovery - July 31, 2015 Category: Drugs & Pharmacology Authors: Sarah Crunkhorn Tags: Research Highlight Source Type: research

Role of AMPKSer-485 in Tau Phosphorylation in IR [Neurobiology]
In this report, we examined the role of IR on the regulation of AMPK phosphorylation and AMPK-mediated Tau phosphorylation. We found that AMPKSer-485, but not AMPKThr-172, phosphorylation is increased in the cortex of db/db and high fat diet-fed obese mice, two mouse models of IR. In vitro, treatment of human cortical stem cell line (HK-5320) and primary mouse embryonic cortical neurons with the AMPK activator, 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR), induced AMPK phosphorylation at both Thr-172 and Ser-485. AMPK activation also triggered Tau dephosphorylation. When IR was mimicked in vitro by chronica...
Source: Journal of Biological Chemistry - July 31, 2015 Category: Chemistry Authors: Kim, B., Figueroa-Romero, C., Pacut, C., Backus, C., Feldman, E. L. Tags: Molecular Bases of Disease Source Type: research

Considerations for the use of restricted, soaked grass hay diets to promote weight loss in the management of equine metabolic syndrome and obesity.
Publication date: Available online 30 July 2015 Source:The Veterinary Journal Author(s): Caroline McG. Argo, Alexandra H.A. Dugdale, Catherine M. McGowan The addition of hay soaking to current nutritional advice for weight loss management for equine obesity lacks clinical evidence. Twelve overweight/obese horses and ponies were used to test the hypothesis that feeding soaked hay at 1.25% of body mass (BM) daily as dry matter (DM) before soaking, would elicit weight losses within the target 0.5-1.0% of BM weekly. Six animals were used to evaluate the impact of nutrient-leaching on the digestibility and daily intakes of...
Source: The Veterinary Journal - July 31, 2015 Category: Veterinary Research Source Type: research

Consumption of sugar sweetened beverage is associated with incidence of metabolic syndrome in Tehranian children and adolescents
Conclusions: Children and adolescents with high intakes of carbonated beverages could be at increased risk of MetS, abdominal obesity, and hypertension. (Source: Nutrition and Metabolism)
Source: Nutrition and Metabolism - July 30, 2015 Category: Nutrition Authors: Parvin MirmiranEmad YuzbashianGolaleh AsghariSomayeh Hosseinpour-NiaziFereidoun Azizi Source Type: research

Iron metabolism and incidence of metabolic syndrome
Conclusion transferrin, not ferritin, is independently associated with an increased risk of incident METS; the protective effect of iron in women should be further explored. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - July 30, 2015 Category: Nutrition Source Type: research

Impact of Community-Based Integrated Traditional Chinese and Western Medicine Metabolic Syndrome Intervention Technology in Rural Residents in Southern Jiangsu, China.
CONCLUSIONS The integrated traditional Chinese and Western medicine MS intervention was effective in deceasing most of the parameters of MS, especially blood pressure, and helping people to do more exercise. The program would be useful to implement in other similar populations. PMID: 26210819 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 29, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Niacin in the Treatment of Hyperlipidemias in Light of New Clinical Trials: Has Niacin Lost its Place?
Authors: Zeman M, Vecka M, Perlík F, Hromádka R, Staňková B, Tvrzická E, Žák A Abstract Niacin is considered to be a powerful drug for the treatment of lipid and lipoprotein abnormalities connected with "residual cardiovascular risk", which persist in high-risk patients even when the target goals of LDL-C are achieved with statin therapy. Recent large randomized clinical studies - AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides) and HPS2-THRIVE (Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) - delivered some disappointing re...
Source: Medical Science Monitor - July 29, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Quality of Life and Hormonal, Biochemical, and Anthropometric Profile Between Olanzapine and Risperidone Users
Abstract This cross-sectional study compared quality of life and side effects in 108 users of olanzapine or risperidone suffering schizophrenia and being attended at psychiatric ambulatory services in Rio Grande do Norte, Brazil. Economic, socio-demographic, anthropometric, biochemical, and hormonal variables were compared. The EuroQoL Five-Dimension Scale (EQ-5D) was used to evaluate quality of life, and side effects were assessed using the Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale and the Simpson–Angus Scale. Data were analysed using the χ2 test and Student’s t test, with a signi...
Source: Psychiatric Quarterly - July 29, 2015 Category: Psychiatry Source Type: research

Dietary Inorganic Nitrate: From Villain to Hero in Metabolic Disease?
This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - July 29, 2015 Category: Nutrition Authors: Ben McNally, Julian L. Griffin, Lee D. Roberts Tags: Review Source Type: research

Glycogen storage disease type Ia (GSDIa) but not Glycogen storage disease type Ib (GSDIb) is associated to an increased risk of metabolic syndrome: possible role of microsomal glucose 6-phosphate accumulation
Background: In GSDIa, glucose 6-phosphate (G6P) accumulates in the endoplasmic reticulum (ER); in GSDIb, G6P levels are reduced in ER. G6P availability directly modulates the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), an ER-bound enzyme playing a key role in the development of the metabolic syndrome (MS).ObjectiveTo evaluate the prevalence of MS and Insulin Resistance (IR) in GSDIa and GSDIb patients.Patients and MethodsThis was a prospective study. All the enrolled patients were followed at the Department of Pediatrics “Federico II” University of Naples for 10 years. Clinical and biochemical par...
Source: Orphanet Journal of Rare Diseases - July 29, 2015 Category: Internal Medicine Authors: Daniela MelisAlessandro RossiRosario PivonelloMariacarolina SalernoFrancesca BalivoSimona SpadarellaGiovanna MuscogiuriRoberto CasaPietro FormisanoGeneroso AndriaAnnamaria ColaoGiancarlo Parenti Source Type: research

A Pilot Study On The Impact Of a Low Fructose Diet and Allopurinol on Clinic Blood Pressure amongst Overweight and Prehypertensive Subjects: A randomized placebo controlled trial
The objective of this study was to compare the effect of low fructose diet and allopurinol or placebo on blood pressure and MS components. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - July 29, 2015 Category: Cardiology Authors: Magdalena Madero, Francisco E. Rodríguez Castellanos, Diana Jalal, Maria Villalobos-Martín, Jonathan Salazar, Armando Vazquez-Rangel, Richard J. Johnson, L. Gabriela Sanchez-Lozada Tags: Research Article Source Type: research

Plasma diacylglycerol composition is a biomarker of metabolic syndrome onset in rhesus monkeys [Research Articles]
Metabolic syndrome is linked with obesity and is often first identified clinically by elevated BMI and elevated levels of fasting blood glucose that are generally secondary to insulin resistance. Using the highly translatable rhesus monkey (Macaca mulatta) model, we asked if metabolic syndrome risk could be identified earlier. The study involved 16 overweight but healthy, euglycemic monkeys, one-half of which spontaneously developed metabolic syndrome over the course of 2 years while the other half remained healthy. We conducted a series of biometric and plasma measures focusing on adiposity, lipid metabolism, and adipose ...
Source: The Journal of Lipid Research - July 29, 2015 Category: Lipidology Authors: Polewski, M. A., Burhans, M. S., Zhao, M., Colman, R. J., Shanmuganayagam, D., Lindstrom, M. J., Ntambi, J. M., Anderson, R. M. Tags: Research Articles Source Type: research

Amisulpride monotherapy may be a choice of maintenance treatment for patients with both bipolar I disorder and metabolic syndrome
(Source: Australian and New Zealand Journal of Psychiatry)
Source: Australian and New Zealand Journal of Psychiatry - July 29, 2015 Category: Psychiatry Authors: Hong, C.-C., Chen, C.-K., Yeh, T.-C., Chu, C.-S., Chen, T.-Y. Tags: Letters Source Type: research

Bariatric surgery as a means to decrease mortality in women with type I endometrial cancer - an intriguing option in a population at risk for dying of complications of metabolic syndrome.
CONCLUSIONS: WLS is a potentially cost-effective intervention in women with low risk, early stage EC, at least in part due to improved quality of life with weight reduction. PMID: 26232518 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 29, 2015 Category: Cancer & Oncology Authors: Neff R, Havrilesky LJ, Chino J, O'Malley DM, Cohn DE Tags: Gynecol Oncol Source Type: research

Metabolic Syndrome and Cardiovascular Risk in Elderly Treated Hypertensive Patients.
CONCLUSIONS: In elderly treated hypertensive patients, MetS is associated with increased cardiovascular risk, but not independently of BP and glucose levels and of organ damage. PMID: 26224400 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 29, 2015 Category: Cardiology Authors: Pierdomenico SD, Pierdomenico AM, Di Tommaso R, Coccina F, Di Carlo S, Cuccurullo F, Porreca E Tags: Am J Hypertens Source Type: research

Association of Metabolic Syndrome and Surgical Factors With Pulmonary Adverse Events, and Longitudinal Mortality in Bariatric Surgery
No abstract available (Source: Survey of Anesthesiology)
Source: Survey of Anesthesiology - July 28, 2015 Category: Anesthesiology Tags: Outcome Study Source Type: research

Natural Nrf2 activators in diabetes
Publication date: 25 August 2015 Source:Clinica Chimica Acta, Volume 448 Author(s): Angélica Saraí Jiménez-Osorio, Susana González-Reyes, José Pedraza-Chaverri Prediabetes and diabetes are rising worldwide. Control of blood glucose is crucial to prevent or delay diabetic complications that frequently result in increased morbidity and mortality. Most strategies include medical treatment and changes in lifestyle and diet. Some nutraceutical compounds have been recognized as adjuvants in diabetes control. Many of them can activate the nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which has been recognized as a...
Source: Clinica Chimica Acta - July 28, 2015 Category: Laboratory Medicine Source Type: research

Central obesity is an independent risk factor for microalbuminuria in both the general Korean women and nondiabetic nonhypertensive subpopulation: Association of microalbuminuria and metabolic syndrome from the Korea National Health and Nutrition Examination Survey 2011–2012
Conclusions Central obesity was an independent risk factor for MAU in the general Korean women as well as in the nondiabetic nonhypertensive women. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 28, 2015 Category: Laboratory Medicine Source Type: research

The association between serum cystatin C and carotid intima–media thickness in metabolic syndrome patients with normal estimated glomerular filtration rate
Conclusions Based on a positive and graded association between cystatin C and CIMT, we assessed that early detection of subclinical atherosclerosis might be necessary in patients with MetS even if at the normal eGFR stage. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 28, 2015 Category: Laboratory Medicine Source Type: research

Insulin resistance is not independently associated with chronic kidney disease in Chinese population: A population-based cross-sectional study
Conclusions IR was not an independently significant predictor of CKD in Chinese population, and MS may contribute greatly to the association between IR and CKD. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 28, 2015 Category: Laboratory Medicine Source Type: research

Iron metabolism and incidence of metabolic syndrome
Whether iron metabolism affects metabolic syndrome (METS) is debated. We assessed the association between several markers of iron metabolism and incidence of MS. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 28, 2015 Category: Nutrition Authors: N. Kilani, P. Vollenweider, G. Waeber, P. Marques-Vidal Source Type: research

Cord Blood Irisin at the Extremes of Fetal Growth
Irisin, a novel myokine with antiobesity properties, drives brown-fat-like conversion of white adipose tissue, thus increasing energy expenditure and improving glucose tolerance. We aimed to investigate circulating irisin concentrations in large-for-gestational-age-(LGA) and intrauterine-growth-restricted-(IUGR) fetuses, both associated with metabolic dysregulation and long-term susceptibility to obesity and metabolic syndrome development. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 28, 2015 Category: Biomedical Science Authors: Stavroula Baka, Ariadne Malamitsi-Puchner, Theodora Boutsikou, Maria Boutsikou, Antonios Marmarinos, Dimitrios Hassiakos, Dimitrios Gourgiotis, Despina D. Briana Source Type: research

Cord Blood Irisin Levels are Positively Correlated with Birth Weight in Newborn Infants
Irisin is a novel myokine, secreted from skeletal muscle after exercise. Irisin mediates exercise-related energy expenditure by turning white adipose tissue (WAT) into brown adipose tissue (BAT). Thus, irisin is considered as a potential biomarker for obesity and metabolic syndrome. Infants born small for gestational age (SGA) have increased risk for metabolic syndrome. However, the physiologic role of irisin in neonates remains to be studied. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 28, 2015 Category: Biomedical Science Authors: Kyoung Eun Joung, Kyung-Hee Park, Andreas Filippiaos, Fadime Dincer, Helen Christou, Christos S. Mantzoros Source Type: research

Stress triggers mitochondrial biogenesis to preserve steroidogenesis in Leydig cells
Publication date: October 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1853, Issue 10, Part A Author(s): Igor A. Gak, Sava M. Radovic, Aleksandra R. Dukic, Marija M. Janjic, Natasa J. Stojkov-Mimic, Tatjana S. Kostic, Silvana A. Andric Adaptability to stress is a fundamental prerequisite for survival. Mitochondria are a key component of the stress response in all cells. For steroid-hormones-producing cells, including also Leydig cells of testes, the mitochondria are a key control point for the steroid biosynthesis and regulation. However, the mitochondrial biogenesis in steroid...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 28, 2015 Category: Molecular Biology Source Type: research

Dopamine-Induced Changes in Serum Erythropoietin and Creatinine Clearance Reflect Risk Factors for Progression of IgA Nephropathy
Conclusions: A decrease in EPO in response to dopamine is associated with a clinical phenotype that is less likely to develop progressive renal disease. These studies suggest that a fall in EPO in response to dopamine likely reflects preserved tubulointerstitial function that cannot be assessed by renal biopsy alone. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - July 27, 2015 Category: Research Tags: Original Articles Source Type: research

Sex-Specific Predictors of Metabolic Syndrome Independent of Its Components
Abstract: To what extent is the metabolic syndrome (MetS) determined beyond its recognized components? In 1702, middle-aged men and women without MetS at baseline, MetS development was identified in 546 participants at a mean of 10.1-year follow-up. Participants subsequently developing MetS had, beyond higher values of MetS traits, significantly higher total and low-density lipoprotein cholesterol, apolipoprotein B, C-reactive protein (CRP), γ-glutamyl transferase (GGT), and lower high-density lipoprotein cholesterol. Females were significantly more frequent never smokers and males had lower values of total testosterone. ...
Source: Journal of Investigative Medicine - July 27, 2015 Category: Research Tags: Original Articles Source Type: research

Clinical outcomes of cryptogenic compared with non‐cryptogenic cirrhosis: A retrospective cohort study
ConclusionsCryptogenic cirrhosis is associated with a longer duration of hospitalization compared with non‐cryptogenic cirrhosis at an early stage of the disease. This difference is due to a greater burden of non‐liver‐related complications in the former. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - July 27, 2015 Category: Gastroenterology Authors: Omar Kadhim Mohammed, Sanjiv Mahadeva Tags: Hepatology Source Type: research

Patients with Alcoholic Cirrhosis have High Prevalence of Metabolic Syndrome
Publication date: June–July 2015 Source:Journal of Clinical and Experimental Hepatology, Volume 5, Supplement 2 Author(s): Manu Mehta, Swastik Agrawal, Sunil Taneja, Ajay Duseja, Radha K. Dhiman, Yogesh Chawla (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - July 27, 2015 Category: Gastroenterology Source Type: research

Nuclear factor {kappa}B-inducing kinase activation as a mechanism of pancreatic {beta} cell failure in obesity
The nuclear factor B (NF-B) pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic β cell dysfunction in the metabolic syndrome. Whereas canonical NF-B signaling is well studied, there is little information on the divergent noncanonical NF-B pathway in the context of pancreatic islet dysfunction. Here, we demonstrate that pharmacological activation of the noncanonical NF-B–inducing kinase (NIK) disrupts glucose homeostasis in zebrafish in vivo. We identify NIK as a critical negative regulator of β cell function, as pharmacological NIK activation result...
Source: The Journal of Experimental Medicine - July 27, 2015 Category: Internal Medicine Authors: Malle, E. K., Zammit, N. W., Walters, S. N., Koay, Y. C., Wu, J., Tan, B. M., Villanueva, J. E., Brink, R., Loudovaris, T., Cantley, J., McAlpine, S. R., Hesselson, D., Grey, S. T. Tags: Articles Source Type: research

High levels of plasma selenium are associated with metabolic syndrome and elevated fasting plasma glucose in a Chinese population: a case-control study
Conclusions Higher levels of plasma selenium might increase the risk of metabolic syndrome and elevated fasting plasma glucose. Selenium supplements should be used with prudence for CVD and cancer prevention. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - July 27, 2015 Category: Biochemistry Source Type: research

Sitagliptin and adiponectin-dependent anti-thrombotic effect
Omoto S, Taniura T, Nishizawa T, Tamaki T, Shouzu A,Nomura S (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - July 26, 2015 Category: Endocrinology Source Type: research

Prevalence and factors associated with metabolic syndrome among Tamils aged over 18 years in Jaffna district, Sri Lanka.
CONCLUSION: One out of four had MS. Old age, urban living and smoking carried higher risk for developing MS in Jaffna community. PMID: 26203430 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - July 26, 2015 Category: Endocrinology Authors: Amarasinghe S, Balakumar S, Arasaratnam V Tags: J Diabetes Metab Disord Source Type: research

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome
Publication date: Available online 26 July 2015 Source:Prostaglandins & Other Lipid Mediators Author(s): Leyre Martínez-Fernández, Laura M. Laiglesia, Ana E. Huerta, J. Alfredo Martínez, María J. Moreno-Aliaga The n-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) have been reported to improve obesity-associated metabolic disorders including chronic inflammation, insulin resistance and dyslipidaemia. Growing evidence exits about adipose tissue as a target in mediating the beneficial effects of these marine n-3 PUFAs in adverse metabolic syndrom...
Source: Prostaglandins and Other Lipid Mediators - July 26, 2015 Category: Lipidology Source Type: research

Relevance of Dietary Glycerophospholipids and sphingolipids to Human health
Publication date: Available online 26 July 2015 Source:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) Author(s): P. Castro-Gómez, A. Garcia-Serrano, F. Visioli, J. Fontecha Glycerophospholipids and sphingolipids participate in a variety of indispensable metabolic, neurological, and intracellular signaling processes. In this didactic paper we review the biological roles of phospholipids and try to unravel the precise nature of their putative healthful activities. We conclude that the biological actions of phospholipids activities potentially be nutraceutically exploited in the adjunct therapy of widel...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 26, 2015 Category: Lipidology Source Type: research

Low Magnesium Levels in Adults with Metabolic Syndrome: a Meta-Analysis.
In conclusion, although there was a high level of heterogeneity, this meta-analysis provided convincing evidence of reduced magnesium levels in adults with metabolic syndrome based on the findings of observational studies. However, the present findings should be validated by additional prospective studies or trans-regional multicenter randomized controlled trials, which generally yield higher-level evidence than case-control studies and cross-sectional studies. CLINICAL TRIAL REGISTRATION NUMBER: NCT02151227 ( ClinicalTrials.gov Protocol Registration System); CRD42015017946 ( www.crd.york.ac.uk/PROSPERO ). PMID: 26...
Source: Biological Trace Element Research - July 26, 2015 Category: Biology Authors: La SA, Lee JY, Kim DH, Song EL, Park JH, Ju SY Tags: Biol Trace Elem Res Source Type: research

Editorial Comment from Dr Cantiello and Dr Damiano to Emerging links between non‐neurogenic lower urinary tract symptoms secondary to benign prostatic obstruction, metabolic syndrome and its components: A systematic review
(Source: International Journal of Urology)
Source: International Journal of Urology - July 26, 2015 Category: Urology & Nephrology Authors: Francesco Cantiello, Rocco Damiano Tags: Editorial Comment Source Type: research

Getting an Insight into the Complexity of Major Chronic Inflammatory and Degenerative Diseases: A Potential New Systemic Approach to Their Treatment.
In this study, we propose a treatment with stem cells differentiation stage factors taken from zebrafish embryos which are able to regulate the genes expression of normal and pathological stem cells in a different specific way. PMID: 26201608 [PubMed - in process] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 25, 2015 Category: Biotechnology Authors: Biava PM, Norbiato G Tags: Curr Pharm Biotechnol Source Type: research

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.
Abstract Insulin resistance is a common feature of obesity and predisposes individuals to various prevalent pathological conditions. G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor kinase 2 (GRK2) integrates several signal transduction pathways and is emerging as a physiologically relevant inhibitor of insulin signaling. GRK2 abundance is increased in humans with metabolic syndrome and in different murine models of insulin resistance. To support GRK2 as a potential drug target in type 2 diabetes and obesity, we investigated whether lowering GRK2 abundance reversed an ongoing systemic ...
Source: Science Signaling - July 25, 2015 Category: Biomedical Science Authors: Vila-Bedmar R, Cruces-Sande M, Lucas E, Willemen HL, Heijnen CJ, Kavelaars A, Mayor F, Murga C Tags: Sci Signal Source Type: research

Synergy between NAFLD and AFLD and potential biomarkers
Publication date: Available online 17 July 2015 Source:Clinics and Research in Hepatology and Gastroenterology Author(s): Raj Lakshman, Ruchi Shah, Karina Reyes-Gordillo, Ravi Varatharajalu Fatty liver (hepatosteatosis) is the earliest abnormality in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) due either to metabolic risk factors associated with insulin resistance and/or metabolic syndrome in the absence of alcohol consumption or to chronic alcohol abuse. When unchecked, both NAFLD and AFLD lead to steatohepatitis, fibrosis, cirrhosis, hepatocellular carcinom...
Source: Clinics and Research in Hepatology and Gastroenterology - July 25, 2015 Category: Gastroenterology Source Type: research

Exposure to Fine Airborne Particulate Matters Induces Hepatic Fibrosis in Murine Models
In this study, we investigated the effect and mechanism of PM2.5 exposure on hepatic fibrogenesis. (Source: Journal of Hepatology)
Source: Journal of Hepatology - July 25, 2015 Category: Gastroenterology Authors: Ze Zheng, Xuebao Zhang, Jiemei Wang, Aditya Dandeka, Hyunbae Kim, Yining Qiu, Xiaohua Xu, Yuqi Cui, Aixia Wang, Lung Chi Chen, Sanjay Rajagopalan, Qinghua Sun, Kezhong Zhang Source Type: research

Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation
Dietary intervention with ω-3 marine fatty acids may potentially modulate inflammation and oxidative stress markers related with CVD, metabolic syndrome, and cancer. The aim of this study was to evaluate whether different proportions of ω-3 EPA and DHA intake provoke a modulation of the production of lipid mediators and then, an influence on different indexes of inflammation and oxidative stress in a controlled dietary animal experiment using Wistar rats. For such scope, a lipidomic SPE-LC-ESI-MS/MS approach previously developed was applied to determine lipid mediators profile in plasma samples. (Source: The Journal of N...
Source: The Journal of Nutritional Biochemistry - July 25, 2015 Category: Biochemistry Authors: Gabriel Dasilva, Manuel Pazos, Eduardo García-Egido, J.M. Gallardo, Isaac Rodríguez, Rafael Cela, Isabel Medina Source Type: research