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This page shows you the latest research publications in this category.

Poly is more Effective than Mono - Unsaturated Fat For dietary management IN the Metabolic Syndrome: The MUFFIN Study
The Metabolic Syndrome (MetS) is highly prevalent and associated with an increased risk for Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Lifestyle recommendations to treat MetS often include the replacement of saturated fats (SFA) and monosacharides with unsaturated fat. However, it is unclear whether metabolic parameters will improve more when the saturated fat in American Heart Association (AHA) diets is replaced with higher concentrations of mono or poly-unsaturated fatty acids (MUFA, PUFA). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 6, 2016 Category: Lipidology Authors: Michael Miller, John D. Sorkin, Laura Mastella, Aimee Sutherland, Jeffrey Rhyne, Patrick Donnelly, Kathy Simpson, Andrew P. Goldberg Source Type: research

The prevalence and risk factors of the metabolic syndrome in inpatients with intellectual disability
ConclusionsThe study indicates a firm prevalence of MetS in a vulnerable population, whereby a minority of contributing factors was determined. Professionals should be particularly alert during the provision of antipsychotics, diet and exercise habits to prevent MetS when treating people with IDs and behavioural problems, and further studies are needed to explore the factors that contribute to the nascence and prevalence of MetS. (Source: Journal of Intellectual Disability Research)
Source: Journal of Intellectual Disability Research - May 6, 2016 Category: Disability Authors: B. Room, O. Timmermans, P. Roodbol Tags: Original Manuscript Source Type: research

An association between diet, metabolic syndrome and lower urinary tract symptoms
Publication date: Available online 4 May 2016 Source:African Journal of Urology Author(s): T.G. Adedeji, A.A. Fasanmade, E.O. Olapade-Olaopa Diet is a key factor in the aetiology of many diseases, including metabolic syndrome and lower urinary tract disorders. Metabolic syndrome is a growing and increasingly expensive health problem in both the developed and the developing world, with an associated rise in morbidity and mortality. On the other hand, lower urinary tract symptoms affect millions of individuals worldwide, lowering their quality of life. Associations have been established between both conditions in existi...
Source: African Journal of Urology - May 4, 2016 Category: Urology & Nephrology Source Type: research

Front cover: Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women
Mol. Nutr. Food Res. 2016, 60, 1206–1212. DOI: 10.1002/mnfr.201500744 There is much controversy about whether all unsaturated fats have the same benefits for metabolic syndrome and weight gain. The strength of the relationships between three unsaturated fatty acids in erythrocytes with measurements of body composition, metabolism, and inflammation in healthy adults is tested. Linoleic acid, but not oleic acid or the sum of long chain omega 3 fatty acids, is associated with increased appendicular lean mass and decreased trunk adipose mass and insulin resistance. The cover image is created by The Ohio State University. (So...
Source: Molecular Nutrition and Food Research - May 4, 2016 Category: Food Science Authors: Martha A. Belury, Rachel M. Cole, Brittney E. Bailey, Jia‐Yu Ke, Rebecca R. Andridge, Janice K. Kiecolt‐Glaser Tags: Front Cover Source Type: research

Dietary Approaches to Stop Hypertension (DASH) Dietary Pattern Is Associated with Reduced Incidence of Metabolic Syndrome in Children and Adolescents
To assess the association of adherence to Dietary Approaches to Stop Hypertension (DASH)-style diet with development of metabolic syndrome (MetS) in children and adolescents. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 4, 2016 Category: Pediatrics Authors: Golaleh Asghari, Emad Yuzbashian, Parvin Mirmiran, Fatemeh Hooshmand, Reza Najafi, Fereidoun Azizi Tags: Original Article Source Type: research

Corrigendum: Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Nature advance online publication 04 May 2016. doi:10.1038/nature18000 Authors: Benoit Chassaing, Omry Koren, Julia K. Goodrich, Angela C. Poole, Shanthi Srinivasan, Ruth E. Ley & Andrew T. Gewirtz (Source: Nature AOP)
Source: Nature AOP - May 4, 2016 Category: Research Authors: Benoit ChassaingOmry KorenJulia K. GoodrichAngela C. PooleShanthi SrinivasanRuth E. LeyAndrew T. Gewirtz Tags: Corrigendum Source Type: research

Cardiorespiratory fitness is positively associated with increased pancreatic beta cell function independent of fatness in individuals with the metabolic syndrome: fitness versus fatness
The vulnerability of individuals with the metabolic syndrome (MetS) to cardiovascular events (CVEs) is attenuated by increased cardiorespiratory fitness (CRF), despite the presence of obesity as a usual component of MetS. To better understand the importance of CRF and body fat in treating this condition, we investigated the relationship between fitness and fatness with pancreatic beta cell function (BCF) indices that are known independent predictors of CVEs. (Source: Journal of Science and Medicine in Sport)
Source: Journal of Science and Medicine in Sport - May 4, 2016 Category: Sports Medicine Authors: Joyce S. Ramos, Lance C. Dalleck, Fabio Borrani, Robert G. Fassett, Jeff S. Coombes Tags: Original research Source Type: research

Cardiorespiratory fitness is positively associated with increased pancreatic beta cell function independent of fatness in individuals with the metabolic syndrome: fitness versus fatness
Conclusions Increased CRF was independently associated with enhanced BCF. This study provides evidence that equal, if not more attention should be dedicated to CRF improvement relative to fat-loss for favorable pancreatic BCF and thus possible reduction in CV risk in individuals with MetS. (Source: Journal of Science and Medicine in Sport)
Source: Journal of Science and Medicine in Sport - May 4, 2016 Category: Sports Medicine Source Type: research

Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice.
Abstract Maternal obesity and gestational diabetes are prevalent worldwide. Offspring of mothers with these conditions weigh more and are predisposed to metabolic syndrome. A hallmark of both conditions is maternal hyperleptinemia, but the role of elevated leptin levels during pregnancy on developmental programming is largely unknown. We previously found that offspring of hyperleptinemic mothers weighed less, and had increased activity. The goal of this study was to determine whether maternal leptin affects offspring insulin sensitivity by investigating offspring glucose metabolism and lipid accumulation. Offspring...
Source: Endocrinology - May 4, 2016 Category: Endocrinology Authors: Talton OO, Pennington KA, Pollock KE, Bates K, Ma L, Ellersieck MR, Clamon Schulz L Tags: Endocrinology Source Type: research

Exercise-based Interventions for Non-alcoholic Fatty Liver Disease: a Meta-analysis and Meta-regression
The burden of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. We performed a meta-analysis to determine the effectiveness of exercise-based lifestyle interventions on liver-specific endpoints in populations with NAFLD and underlying metabolic disorders such as obesity, type-2 diabetes, or the metabolic syndrome. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 4, 2016 Category: Gastroenterology Authors: Lorenzo A. Orci, Karim Gariani, Graziano Oldani, Vaihere Delaune, Philippe Morel, Christian Toso Source Type: research

A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition.
CONCLUSIONS: The data document influence of a common genetic variant on susceptibility to endothelial dysfunction and its response to sildenafil treatment. PMID: 27144937 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 4, 2016 Category: Endocrinology Authors: Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA Tags: J Clin Endocrinol Metab Source Type: research

Endocrine and Metabolic Profile of Different Phenotypes of Polycystic Ovarian Syndrome
Conclusion All phenotypes of PCOS had deranged endocrine and metabolic profile compared to controls, but prevalence of IR and metabolic syndrome was maximum in hyperandrogenic phenotypes which require a strict surveillance for prospective metabolic disorders as compared to O + P phenotype. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - May 4, 2016 Category: OBGYN Source Type: research

Impact of dulaglutide
Thompson AM, Trujillo JM (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 3, 2016 Category: Endocrinology Source Type: research

Rheumatoid arthritis and metabolic syndrome
(Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research

Metabolic syndrome in patients with rheumatoid arthritis followed at a University Hospital in Northeastern Brazil
Conclusions: RA patients in a tertiary center in Northeastern Brazil showed high prevalence of MS. It is worth noting that almost all patients had MS and abdominal obesity, which has important practical implications. In addition to the components of MS, age and smoking were associated with this syndrome.RESUMO Introdução: Pacientes com artrite reumatoide (AR) têm 30 a 60% mais chances de desenvolver doenças cardiovasculares (DCV) do que a população geral. A síndrome metabólica (SM), definida por um conjunto de fatores de risco cardiovasculares, confere maior risco de DCV e diabete. A associação da SM com AR ainda...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research

Renal function is impaired in normotensive chronic HCV patients: role of insulin resistance
In conclusion, we demonstrate that HCV patients have a significant reduction of e-GFR and that insulin resistance is the major predictor of renal dysfunction. (Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - May 3, 2016 Category: Emergency Medicine Source Type: research

Oxidative DNA damage and oxidized low density lipoprotein in Type II diabetes mellitus among patients with Helicobacter pylori infection
Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrom... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 3, 2016 Category: Endocrinology Authors: Wesam Ahmed Nasif, Mohammed Hasan Mukhtar, Mohammed Mahmoud Nour Eldein and Sami Sadagah Ashgar Source Type: research

Distinct metabolic effects of resveratrol on lipogenesis markers in mice adipose tissue treated with high-polyunsaturated fat and high-protein diets
Conclusions The obtained results show that resveratrol decreases lipogenesis markers and metabolic parameters in the setting of a high-protein diet. Moreover, resveratrol decreased total cholesterol in both diets. These results point to the increased potential of resveratrol use in prevention of metabolic syndrome, acting on different dietary compositions. (Source: Life Sciences)
Source: Life Sciences - May 3, 2016 Category: Biology Source Type: research

Combined Aerobic and Resistance Training Effects on Glucose Homeostasis, Fitness, and Other Major Health Indices: A Review of Current Guidelines
Abstract The combination of aerobic and resistance training (AER + RES) is recommended by almost every major organization to improve health-related risk factors associated with sedentary behavior. Since the release of the Physical Activity Guidelines for Americans in 2008, several large well-controlled trials and ancillary reports have been published that provide further insight into the effects of AER + RES on health-related outcomes. The current manuscript examines the literature on the effects of AER + RES on major clinical outcomes, including glucose homeostasis, cardiorespiratory fitness (CRF), and musc...
Source: Sports Medicine - May 3, 2016 Category: Sports Medicine Source Type: research

Wasabi leaf extracts attenuate adipocyte hypertrophy through PPARγ and AMPK.
Abstract Hypertrophy of adipocytes in obese adipose tissues causes metabolic abnormality by adipocytokine dysregulation, which promotes type 2 diabetes mellitus, hypertension, and dyslipidemia. We investigated the effects of wasabi (Wasabia japonica Matsum) leaf extracts on metabolic abnormalities in SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP/ZF), which are a model of metabolic syndrome. Male SHRSP/ZF rats aged 7 weeks were divided into two groups: control and wasabi leaf extract (WLE) groups, which received water or oral treatment with 4 g/kg/day WLE for 6 weeks. WLE improved the body weight gain and high blood pressur...
Source: Bioscience, Biotechnology, and Biochemistry - May 3, 2016 Category: Biochemistry Authors: Oowatari Y, Ogawa T, Katsube T, Iinuma K, Yoshitomi H, Gao M Tags: Biosci Biotechnol Biochem Source Type: research

The beneficial potential of polyphenol-enriched fraction from Erigerontis Herba on metabolic syndrome
Conclusions EHP exerted promising effects on diet-induced obesity and hepatic steatosis in C57Bl/6 mice model. It also exerted significant vasodilative effect ex vivo, suggesting the potential of EHP to be developed as a dietary supplement for metabolic syndrome. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 2, 2016 Category: Drugs & Pharmacology Source Type: research

Metabolic Syndrome in Children and Adolescents
(Source: Pediatrics in Review)
Source: Pediatrics in Review - May 2, 2016 Category: Pediatrics Authors: Wittcopp, C., Conroy, R. Tags: Medical Education, Journal CME, Endocrinology, Metabolic Disorders Articles Source Type: research

Metabolic syndrome and shoulder arthroplasty: epidemiology and peri-operative outcomes
Conclusions Metabolic syndrome is increasing rapidly among shoulder arthroplasty patients and is associated with considerable peri-operative morbidity and resource utilization. Greater awareness of metabolic syndrome and its health consequences may contribute to improvements in the peri-operative management of shoulder arthroplasty patients. (Source: International Orthopaedics)
Source: International Orthopaedics - May 2, 2016 Category: Orthopaedics Source Type: research

Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by Fibroscan in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the liver manifestation of the metabolic syndrome. With the worldwide burden of obesity, NAFLD has reached a median prevalence of 20-30% in the general population and thus become the most prevalent cause of chronic liver disease worldwide [1,2]. NAFLD is a heterogeneous entity that covers a wide spectrum of liver lesions ranging from bland steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and finally cirrhosis with its life-threatening complications. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 2, 2016 Category: Gastroenterology Authors: Jérôme Boursier, Julien Vergniol, Anne Guillet, Jean-Baptiste Hiriart, Adrien Lannes, Brigitte Le Bail, Sophie Michalak, Faiza Chermak, Sandrine Bertrais, Juliette Foucher, Frédéric Oberti, Maude Charbonnier, Isabelle Fouchard-Hubert, Marie-Christine Source Type: research

Sitagliptin versus placebo in the treatment of nonalcoholic fatty liver disease: A randomized controlled trial
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States and the Western World.[1–4] NAFLD is commonly associated with metabolic syndrome features, including obesity, dyslipidemia, and diabetes.[5–7] The presence of pre-diabetes and diabetes is associated with the progressive form of NAFLD also termed as nonalcoholic steatohepatitis (NASH).[8,9] Several anti-diabetic therapies have been investigated in the treatment of NASH with varying success, including metformin,[10–12] rosiglitazone,[13,14] pioglitazone,[15–17] and liraglutide. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 2, 2016 Category: Gastroenterology Authors: Jeffrey Cui, Len Philo, Phirum Nguyen, Heather Hofflich, Carolyn Hernandez, Ricki Bettencourt, Lisa Richards, Joanie Salotti, Archana Bhatt, Jonathan Hooker, William Haufe, Catherine Hooker, David A. Brenner, Claude B. Sirlin, Rohit Loomba Source Type: research

Which parameters affect long-term mortality in older adults: is comprehensive geriatric assessment a predictor of mortality?
CONCLUSIONS: The results of the study demonstrated the need for addressing modifiable risk factors such as smoking, metabolic syndrome, and undernutrition in older adults. PMID: 27137217 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - May 2, 2016 Category: Geriatrics Authors: Kara O, Canbaz B, Kizilarslanoglu MC, Arik G, Sumer F, Aycicek GS, Varan HD, Kilic MK, Dogru RT, Cınar E, Kuyumcu ME, Yesil Y, Ulger Z, Yavuz BB, Halil M, Cankurtaran M Tags: Aging Clin Exp Res Source Type: research

Relationship between non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance in Korean adults: A cross-sectional study
Conclusions NAFLD is associated with the prevalence of metabolic syndrome, independent of adiposity. In females, NAFLD may be a more important factor than obesity for risk of metabolic syndrome. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 1, 2016 Category: Laboratory Medicine Source Type: research

Na+-sensitive elevation in blood pressure is ENaC independent in diet-induced obesity and insulin resistance
The majority of patients with obesity, insulin resistance, and metabolic syndrome have hypertension, but the mechanisms of hypertension are poorly understood. In these patients, impaired sodium excretion is critical for the genesis of Na+-sensitive hypertension, and prior studies have proposed a role for the epithelial Na+ channel (ENaC) in this syndrome. We characterized high fat-fed mice as a model in which to study the contribution of ENaC-mediated Na+ reabsorption in obesity and insulin resistance. High fat-fed mice demonstrated impaired Na+ excretion and elevated blood pressure, which was significantly higher on a hig...
Source: AJP: Renal Physiology - May 1, 2016 Category: Urology & Nephrology Authors: Nizar, J. M., Dong, W., McClellan, R. B., Labarca, M., Zhou, Y., Wong, J., Goens, D. G., Zhao, M., Velarde, N., Bernstein, D., Pellizzon, M., Satlin, L. M., Bhalla, V. Tags: ARTICLES Source Type: research

[Diabetic dyslipidaemia and the atherosclerosis].
Abstract The incidence and the public health importance of diabetes mellitus are growing continuously. Despite the improvement observed in the latest years, the leading cause of morbidity and mortality of diabetics are cardiovascular diseases. The diagnosis of diabetes mellitus constitutes such a high risk as the known presence of vascular disease. Diabetic dyslipidaemia is characterised by high fasting and postprandial triglyceride levels, low HDL level, and slightly elevated LDL-cholesterol with domination of atherogenic small dense LDL. These are not independent components of the atherogenic dyslipidaemia, but a...
Source: Orvosi Hetilap - May 1, 2016 Category: Journals (General) Authors: Márk L, Dani G Tags: Orv Hetil Source Type: research

[Hyper-free fatty acidemia - insulin resistance and β-cell death].
Abstract The increasing prevalence of type 2 diabetes correlates with the rapid spread of obesity worldwide. Adipocytes are strained by the demand of excessive storage, and the local inflammation accelerates triglyceride turnover, which elevates the plasma levels of free fatty acids. Sustained hyper-free fatty acidemia leads to disturbances in cellular functions (lipotoxicity) or even to programmed cell death. Activated stress kinases interfere with insulin signaling, and often facilitate apoptosis. Hyper-free fatty acidemia, therefore, links obesity to diabetes through insulin resistance and β-cell damage. Lipoto...
Source: Orvosi Hetilap - May 1, 2016 Category: Journals (General) Authors: Csala M Tags: Orv Hetil Source Type: research

Prevalence of elevated alanine transaminase (ALT) in Australia and its relationship to metabolic risk factors: a cross sectional study of 9,447 people.
Conclusion & ImplicationsThese data demonstrate a high prevalence of elevated ALT in the general population that is closely associated with metabolic risk factors. Individuals with elevated ALT should be evaluated for co‐existent metabolic disorders. This article is protected by copyright. All rights reserved. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - May 1, 2016 Category: Gastroenterology Authors: Suzanne E Mahady, Joanne Gale, Petra Macaskill, Jonathan C Craig, Jacob George Tags: Original Article ‐ Hepatology (Clinical) Source Type: research

The relationship between dental caries and metabolic syndrome among 13,998 middle‐aged urban Chinese
ConclusionsDental caries was associated with MetS among middle‐aged Chinese in the present study. (Source: Journal of Diabetes)
Source: Journal of Diabetes - May 1, 2016 Category: Endocrinology Authors: Xia Cao, Dongliang Wang, Jiansong Zhou, Hong Yuan, Zhiheng Chen Tags: Original Article Source Type: research

Flaxseed Supplementation in Metabolic Syndrome Management: A Pilot Randomized, Open‐labeled, Controlled Study
The aim of this study was to evaluate the efficacy of flaxseed supplementation plus lifestyle modification in comparison with lifestyle modification alone in the management of metabolic syndrome (MetS). A randomized controlled clinical trial was conducted on 44 patients with MetS. Participants were assigned to receive either the lifestyle advice and 30‐g brown milled flaxseed daily or only the lifestyle advice as the control group. The percentage of individuals with MetS decreased from baseline by 50% and 82% in the control and intervention group, respectively. The reversion rate of central obesity was higher in the flax...
Source: Phytotherapy Research - May 1, 2016 Category: Biochemistry Authors: Zahra Yari, Mehran Rahimlou, Hossein Poustchi, Azita Hekmatdoost Tags: Research Article Source Type: research

Role of three adipokines in metabolic syndrome.
Authors: Losano G, Folino A, Rastaldo R PMID: 27129084 [PubMed - as supplied by publisher] (Source: Polskie Archiwum Medycyny Wewnetrznej)
Source: Polskie Archiwum Medycyny Wewnetrznej - April 30, 2016 Category: Internal Medicine Tags: Pol Arch Med Wewn Source Type: research

The Contribution of Autonomic Imbalance to the Development of Metabolic Syndrome
Conclusions: In this community sample, low HRV by both measures (SDNN and root mean square of the standard deviation), high RHR, increased age, cigarette smoking, and being male significantly increased the odds of developing metabolic syndrome within 12 years of baseline. (Source: Psychosomatic Medicine)
Source: Psychosomatic Medicine - April 30, 2016 Category: Psychiatry & Psychology Tags: Original Articles Source Type: research

Increased Waist‑to‑height Ratio May Contribute to Age‑related Increase in Cardiovascular Risk Factors
Conclusions: Age‑related increase of CVD risk factors occurred independent of lifestyle habits. WHtR, but not BMI, may partially contribute to the age‑related increase in CVD risk factors.Keywords: Age, cardiovascular diseases, dietary habits, waist‑to‑height ratio (Source: International Journal of Preventive Medicine)
Source: International Journal of Preventive Medicine - April 30, 2016 Category: Global & Universal Source Type: research

The levels of Toxoplasma gondii profilin and adiponectin in obese patients complicated with or without metabolic syndrome as compared to non-obese patients
Conclusions The level of T. gondii profilin in obese patients was higher than that in the non-obese, whereas the level of adiponectin in obese patients complicated with metabolic syndrome was lower than that in the obese without metabolic syndrome and non-obese patients. (Source: Asian Pacific Journal of Tropical Disease)
Source: Asian Pacific Journal of Tropical Disease - April 30, 2016 Category: Tropical Medicine Source Type: research

Aortic Valve Sclerosis As a Marker of Atherosclerosis: Novel Insights From Hepatic Steatosis
Nowadays, aortic valve sclerosis (AVSc) might be considered an atherosclerosis-like process due to significant association with age, male gender and with some major features of metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD) has been recognised as a clinical expression of the metabolic syndrome and as a predictor of cardiovascular events. We aim, with this meta-analysis, to evaluate the correlation between NAFLD and AVSc; this finding might suggest new insights and interactions among NAFLD, AVSc and the atherosclerotic process. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 30, 2016 Category: Cardiology Authors: Matteo Nicola Dario Di Minno, Alessandro Di Minno, Pasquale Ambrosino, Paola Songia, Elena Tremoli, Paolo Poggio Source Type: research

The Impact of Body weight Gain on Nonalcoholic Fatty Liver Disease and Metabolic Syndrome During Earlier and Later Adulthood
Body weight gain adds risk for metabolic disorders and there are different metabolic changes in earlier and later adulthood. However, its impact on non-alcoholic fatty liver disease (NAFLD) was indeterminate. The aim of current study was to evaluate the impact of body weight gain on NAFLD and metabolic syndrome (MetS) during overall, earlier (25 – 40 y) and later (over 40 y) adulthood. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 30, 2016 Category: Endocrinology Authors: Shanshan Du, Cheng Wang, Wei Jiang, Chunlong Li, Yanchuan Li, Rennan Feng, Changhao Sun Source Type: research

Hypertension Is a Key Feature of the Metabolic Syndrome in Subjects Aging with HIV
Abstract With widespread and effective antiretroviral therapy, the life expectancy in the HIV population has dramatically improved over the last two decades. Consequently, as patients are aging with HIV, other age-related comorbidities, such as metabolic disturbances and cardiovascular disease (CVD), have emerged as important causes of morbidity and mortality. An overrepresentation of traditional cardiovascular risk factors (RF), toxicities associated with long exposure to antiretroviral therapy, together with residual chronic inflammation and immune activation associated with HIV infection are thought to predisp...
Source: Current Hypertension Reports - April 30, 2016 Category: Primary Care Source Type: research

Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor
A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trélat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - April 29, 2016 Category: Endocrinology Authors: Andreia Latanza Gomes Mathez, Debora Moroto, Sergio Atala Dib and Joao Roberto de Sa Source Type: research

Adenosine monophosphate–activated protein kinase in diabetic nephropathy
Publication date: Available online 8 March 2016 Source:Kidney Research and Clinical Practice Author(s): Yaeni Kim, Cheol Whee Park Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and its pathogenesis is complex and has not yet been fully elucidated. Abnormal glucose and lipid metabolism is key to understanding the pathogenesis of DN, which can develop in both type 1 and type 2 diabetes. A hallmark of this disease is the accumulation of glucose and lipids in renal cells, resulting in oxidative and endoplasmic reticulum stress, intracellular hypoxia, and inflammation, eventually leading to glom...
Source: Kidney Research and Clinical Practice - April 29, 2016 Category: Urology & Nephrology Source Type: research

Net Blood Pressure Reduction Following 9 Months of Lifestyle and High‐Intensity Interval Training Intervention in Individuals With Abdominal Obesity
The authors aimed to study the impact of a combined 9‐month lifestyle program (Mediterranean diet nutritional counselling, and high‐intensity interval training twice a week) on blood pressure (BP) in individuals with abdominal obesity, taking into account the regression‐to‐the‐mean phenomena. A total of 115 participants (53±9 years; 84 women; waist circumference [WC]: 111±13 cm; systolic/diastolic BP [SBP/DBP]: 133±13/82±8 mm Hg; 13% diabetics; 12% smokers; and 30% taking antihypertensive therapy) were retrospectively analyzed before and after the program. After 9 months, we observed an improvement in weight ...
Source: The Journal of Clinical Hypertension - April 29, 2016 Category: Cardiology Authors: Philippe Sosner, Laurent Bosquet, Daniel Herpin, Valérie Guilbeault, Elise Latour, Laurie Paquette‐Tannir, Martin Juneau, Anil Nigam, Mathieu Gayda Tags: Original Paper Source Type: research

Androgen receptor (AR) in cardiovascular diseases
Cardiovascular diseases (CVDs) are still the highest leading cause of death worldwide. Several risk factors have been linked to CVDs, including smoking, diabetes, hyperlipidemia, and gender among others. Sex hormones, especially the androgen and its receptor, androgen receptor (AR), have been linked to many diseases with a clear gender difference. Here, we summarize the effects of androgen/AR on CVDs, including hypertension, stroke, atherosclerosis, abdominal aortic aneurysm (AAA), myocardial hypertrophy, and heart failure, as well as the metabolic syndrome/diabetes and their impacts on CVDs. Androgen/AR signaling exacerba...
Source: Journal of Endocrinology - April 29, 2016 Category: Endocrinology Authors: Huang, C.-K., Lee, S. O., Chang, E., Pang, H., Chang, C. Tags: Review Source Type: research

A Comparative Study of Lung Host Defense in Murine Obesity Models: Insights Into Neutrophil Function.
CONCLUSIONS: Obesity-associated impairment of host response to lung infection is characterized by defects in neutrophil recruitment and survival. Yet, critical differences exist between commonly used mouse models of obesity, and may reflect variable penetrance of elements of the metabolic syndrome as well as other factors. PMID: 27128821 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - April 29, 2016 Category: Molecular Biology Authors: Ubags ND, Burg E, Antkowiak M, Wallace AM, Dilli E, Bement J, Wargo MJ, Poynter ME, Wouters EF, Suratt BT Tags: Am J Respir Cell Mol Biol Source Type: research

Calculated insulin resistance correlates with stone-forming urinary metabolic changes and greater stone burden in high-risk stone patients.
CONCLUSIONS: Previous studies have demonstrated a correlation between metabolic syndrome, diabetes, and nephrolithiasis. This report demonstrates a quantitative increase in stone burden among patients with calculated insulin resistance. The pathway for this greater stone burden may be related to the urinary metabolic changes noted among patients with insulin resistance. In the future, targeting reduction of fasting insulin levels may represent a key element of stone disease prevention. PMID: 27125629 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 29, 2016 Category: Urology & Nephrology Authors: Tran TY, Flynn M, O'Bell J, Pareek G Tags: Clin Nephrol Source Type: research

Importance of cystatin C and uric acid levels in the association of cardiometabolic risk factors in Japanese junior high school students.
CONCLUSIONS: CysC had significant associations with both creatinine and SUA in Japanese junior high school students. The concomitant elevation of serum CysC and SUA levels was associated with subclinical lipid metabolism dysregulation, and suggested the presence of cardiometabolic risk accumulation. PMID: 27138369 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - April 29, 2016 Category: Cardiology Authors: Harada M, Izawa A, Hidaka H, Nakanishi K, Terasawa F, Motoki H, Yazaki Y, Ikeda U, Hongo M, Study Project on Prevention of Metabolic Syndrome among Children, Adolescents, and Young Adults in Shinshu Tags: J Cardiol Source Type: research

Association between temporomandibular disorders and obesity
This study investigated the relationship between TMD and body mass index (BMI) in a large representative sample of the South Korean population using data from the Korea National Health and Nutrition Examination Survey (KNHANES). en and women with TMD showed decreased prevalence of abdominal obesity. Women with TMD had lower age, lower BMI, lower metabolic syndromic waist circumference, lower prevalence of metabolic syndrome, and lower prevalence of diabetes compared with the group without TMD. (Source: Journal of Cranio-Maxillofacial Surgery)
Source: Journal of Cranio-Maxillofacial Surgery - April 28, 2016 Category: ENT & OMF Authors: Eunmi Rhim, Kyungdo Han, Kyoung-In Yun Source Type: research

Orange beverage ameliorates high-fat-diet-induced metabolic disorder in mice
Publication date: June 2016 Source:Journal of Functional Foods, Volume 24 Author(s): B. Escudero-López, M.S. Fernández-Pachón, G. Herrero-Martín, Á. Ortega, I. Cerrillo, F. Martín, G. Berná Metabolic syndrome (MetS) refers to a group of disorders that includes insulin resistance, central obesity, arterial hypertension and hyperlipidaemia. Regular consumption of bioactive compounds has consistently been associated with a reduced risk of these disorders. The aim of this study was to determine if an orange beverage with high concentrations of bioactive compounds (flavanones, carotenoids, melatonin, and ascorbi...
Source: Journal of Functional Foods - April 28, 2016 Category: Nutrition Source Type: research

Lipid Accumulation Product: a Simple and Accurate Index for Predicting Metabolic Syndrome in Patients with Adult Growth Hormone Deficiency
Conclusions: LAP was associated with MS and had a strong and reliable diagnostic accuracy for MS in AGHD patients.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 28, 2016 Category: Endocrinology Authors: Chan, L.Xue, H.Xiaoya, Z.Jiajia, X.Wei, R.Linman, L.Qing, L.Lan, L. Tags: Article Source Type: research