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This page shows you the latest research publications in this category.

Tetrapleura tetraptera spice attenuates high-carbohydrate, high-fat diet-induced obese and type 2 diabetic rats with metabolic syndrome features
Conclusions: The present study thereby demonstrates the anti-insulin resistance, antilipidemic, anti-obesity, hypotensive and anti-inflammatory properties of HET; hence it has the potential to be further developed for the management of MetS such as obesity, T2DM and hypertension. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - May 24, 2015 Category: Epidemiology Authors: Dieudonne KuateAnne KengneCabral BiapaBoris AzantsaWan Wan Muda Source Type: research

Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity
This study aimed to assess the relationship between insulin resistance, lipid profile and OPG levels in obese and non-obese sub-Saharan African women. Methods: Sixty obese (44) and non-obese (16) volunteer women aged 18 to 40 years were recruited in this cross-sectional study. Their clinical (age, height, weight, waist circumference, systolic and diastolic blood pressures) and biochemical parameters (fasting blood glucose, total cholesterol, high density lipoprotein-cholesterol (HDL-C)) were measured using standard methods. Insulin levels were measured using an electrochemiluminescence immunoassay, while OPG levels were m...
Source: Diabetology and Metabolic Syndrome - May 23, 2015 Category: Endocrinology Authors: Clarisse Ayina AyinaEugene SobngwiMickael EssoumaJean NoubiapPhilippe BoudouLaurent Etoundi NgoaJean Gautier Source Type: research

New Challenges in the Diagnosis and Management of Cystic Fibrosis
New challenges have arisen in the diagnosis and clinical management of children with cystic fibrosis (CF), especially during the past few years, when novel-but-confusing terminology has been introduced. We will briefly explain the origin of and hopefully clarify the new terms, including CF transmembrane conductance regulator (CFTR)-related metabolic syndrome (CRMS), CFTR-related disease (CFTR-RD), CF Screen Positive, Inconclusive Diagnosis (CFSPID), and delayed CF. Traditionally, CF has relied on the clinical recognition of characteristic signs and symptoms, but newborn screening (NBS) has truly been a “game changer,” ...
Source: The Journal of Pediatrics - May 22, 2015 Category: Pediatrics Authors: Hara Levy, Philip M. Farrell Tags: Editorial Source Type: research

Hypolipidemic, antioxidant and anti—atherosclerogenic effects of aqueous extract of Zanthoxylum heitzii stem bark in diet—induced hypercholesterolemic rats
Conclusions These observations strongly suggest that stem bark aqueous extract of Zanthoxylum heitzii has anti-atherosclerogenic properties, at least partly mediated by antioxidant and hypolipidemic effects. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - May 22, 2015 Category: Tropical Medicine Source Type: research

The relationship of circulating fetuin-a with liver histology and biomarkers of systemic inflammation in nondiabetic subjects with nonalcoholic fatty liver disease
Conclusion: This study demonstrated that plasma fetuin-A levels are not correlated with the hepatic histology and systemic markers of inflammation in nondiabetic subjects with NAFLD. Our data also suggested that age is significantly associated with fetuin-A in this clinically relevant condition. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 22, 2015 Category: Gastroenterology Authors: Gurkan CelebiHalil GencHasan GurelErdim SertogluMuammer KaraSerkan TapanCengizhan AcikelYildirim KarsliogluCemal Nuri ErcinTeoman Dogru Source Type: research

γ-glutamyl transpeptidase in men and alanine aminotransferase in women are the most suitable parameters among liver function tests for the prediction of metabolic syndrome in nonviral hepatitis and nonfatty liver in the elderly
Conclusion: Among all the different LFTs, γ-GT (>16 U/L) in male and ALT (>21 U/L) in female were the best predictors for the development of MetS in healthy elderly. These two liver markers could be an ancillary test in predicting future MetS development/diagnosis. Elevation of the LFTs without underlying liver diseases should be treated as a warning sign of the possible MetS development in the elderly. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 22, 2015 Category: Gastroenterology Authors: Dee PeiTe-Lin HsiaTing-Ting ChaoJiunn-Diann LinChun-Hsien HsuChung-Ze WuChang-Hsun HsiehYao-Jen LiangYen-Lin Chen Source Type: research

Maternal metabolic syndrome, preeclampsia and small for gestational age infancy
To explore to what extent the presence of cardiometabolic and cardiovascular risk constitutions differ between pregnancies complicated by small for gestational infancy, preeclampsia or a combination of both. STUDY DESIGN: We conducted a cohort study in women after pregnancies complicated by placental syndrome with fetal manifestations (small for gestational age (SGA) infancy (n=113)), maternal manifestations (preeclampsia (PE) (n=729)), or both (n=461). Independent sample t-test was used to compare cardiometabolic and cardiovascular risk factors between groups. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 22, 2015 Category: OBGYN Authors: Mieke C.E. Hooijschuur, Chahinda Ghossein-Doha, Salwan Al-Nasiry, M.E.A. Spaanderman Source Type: research

Adipose Tissue in Metabolic Syndrome: Onset and Progression of Atherosclerosis
Metabolic syndrome (MetS) should be considered a clinical entity when its different symptoms share a common etiology: obesity/insulin resistance as a result of a multi-organ dysfunction. The main interest in treating MetS as a clinical entity is that the addition of its components drastically increases the risk of atherosclerosis. In MetS, the adipose tissue plays a central role along with an unbalanced gut microbiome, which has become relevant in recent years. Once visceral adipose tissue (VAT) increases, dyslipidemia and endothelial dysfunction follow as additive risk factors. (Source: Archives of Medical Research)
Source: Archives of Medical Research - May 22, 2015 Category: Research Authors: María Luna-Luna, Aida Medina-Urrutia, Gilberto Vargas-Alarcón, Fernanda Coss-Rovirosa, Jesús Vargas-Barrón, Óscar Pérez-Méndez Tags: Review Article Source Type: research

Prevalence of cardiovascular and metabolic events in patients prescribed clozapine: a retrospective observational, clinical cohort study.
CONCLUSION: Male patients who are obese at any point during treatment and older at treatment commencement may be the most vulnerable to adverse CV and metabolic events. While future studies using a matched case-control design may be required to verify these findings, we recommend that treating clinicians consider these risks when assessing patient suitability to clozapine therapy. PMID: 25986036 [PubMed - in process] (Source: Current Drug Safety)
Source: Current Drug Safety - May 21, 2015 Category: Drugs & Pharmacology Authors: Hyde N, Dodd S, Venugopal K, Purdie C, Berk M, O'Neil A Tags: Curr Drug Saf Source Type: research

The diet-induced metabolic syndrome is accompanied by whole-genome epigenetic changes
Abstract Consuming a high-fat/high-fructose diet (HFD) starting at a young age leads to the development of obesity and to the progression of metabolic syndrome (MS). We are interested in the relationship between MS and DNA methylation as a mediator of the metabolic memory and the early appearance of these diseases in the progeny. To this end, Wistar rats were fed a HFD for 1 year, and every 12 weeks, biochemical analyses were performed. After 24 weeks, animals fed the HFD showed alterations related to MS such as elevated blood levels of fasting glucose, triglycerides, and insulin compared with their litter...
Source: Genes and Nutrition - May 21, 2015 Category: Nutrition Source Type: research

Metabolic syndrome in Spanish adolescents and its association with birth weight, breastfeeding duration, maternal smoking, and maternal obesity: a cross-sectional study
Conclusions Those subjects born with a higher than average birth weight had a greater risk of developing MetS in childhood and adolescence. Breastfeeding children for longer than 6 months protected them from MetS in their early years as well as in their teens. Other risk factors for MetS were maternal smoking during pregnancy as well as maternal overweight and obesity. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - May 21, 2015 Category: Nutrition Source Type: research

Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome
This study tested the hypothesis that ROS scavenging will improve mitochondrial function and insulin sensitivity in the hearts of rodent models with varying degrees of insulin resistance and hyperglycemia. The catalytic antioxidant MnTBAP was administered to the uncoupling protein-diphtheria toxin A (UCP-DTA) mouse model of insulin resistance (IR) and obesity, at early and late time points in the evolution of IR, and to db/db mice with severe obesity and type-two diabetes. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - May 21, 2015 Category: Cytology Authors: Olesya Ilkun, Nicole Wilde, Joseph Tunei, Karla M.P. Pires, Yi Zhu, Heiko Bugger, Jamie Soto, Benjamin Wayment, Curtis Olsen, Sheldon E. Litwin, E. Dale Abel Tags: Original Article Source Type: research

Metabolic syndrome in drug-naïve and drug-free patients with schizophrenia and in their siblings
We tested the hypothesis that metabolic disturbances in people with schizophrenia exist as a part of the schizophrenic syndrome, even when the antipsychotic drug effect is eliminated. We aimed to determine the prevalence of metabolic syndrome among patients with schizophrenia who were antipsychotic drug-naive or drug-free and their siblings for comparison with healthy controls. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 21, 2015 Category: Psychiatry Authors: Aslı Enez Darcin, Sercin Yalcin Cavus, Nesrin Dilbaz, Hasan Kaya, Eylem Dogan Source Type: research

Central Inhibition of IKK{beta}/NF-{kappa}B Signaling Attenuates High-Fat Diet-Induced Obesity and Glucose Intolerance
Metabolic inflammation in the central nervous system might be causative for the development of overnutrition-induced metabolic syndrome and related disorders, such as obesity, leptin and insulin resistance, and type 2 diabetes. Here we investigated whether nutritive and genetic inhibition of the central IB kinase β (IKKβ)/nuclear factor-B (NF-B) pathway in diet-induced obese (DIO) and leptin-deficient mice improves these metabolic impairments. A known prominent inhibitor of IKKβ/NF-B signaling is the dietary flavonoid butein. We initially determined that oral, intraperitoneal, and intracerebroventricular adm...
Source: Diabetes - May 21, 2015 Category: Endocrinology Authors: Benzler, J.; Ganjam, G. K.; Pretz, D.; Oelkrug, R.; Koch, C. E.; Legler, K.; Stohr, S.; Culmsee, C.; Williams, L. M.; Tups, A. Tags: Metabolism Source Type: research

Relations Between Subclinical Disease Markers and Type 2 Diabetes, Metabolic Syndrome, and Incident Cardiovascular Disease: The Jackson Heart Study
CONCLUSIONS In our community-based sample of AAs, we observed a moderately high prevalence of subclinical disease, which in turn translated into a greater risk of CVD, especially in people with MetS and DM. (Source: Diabetes Care)
Source: Diabetes Care - May 21, 2015 Category: Endocrinology Authors: Xanthakis, V.; Sung, J. H.; Samdarshi, T. E.; Hill, A. N.; Musani, S. K.; Sims, M.; Ghraibeh, K. A.; Liebson, P. R.; Taylor, H. A.; Vasan, R. S.; Fox, E. R. Tags: Epidemiology/Health Services Research Source Type: research

The association between hyperandrogenemia and the metabolic syndrome in morbidly obese women
Background: Female abdominal obesity is associated with hyperandrogenemia (HA), but few studies have addressed the possible association between HA and metabolic syndrome (MetS) among obese women. Some studies indicate that insulin resistance may cause HA through different mechanisms. On the other hand, a bidirectional relationship between HA and insulin resistance has been suggested. Thus, we aimed to investigate if morbidly obese women with HA had higher odds of MetS and its components than those without HA (controls), independent of polycystic ovarian syndrome (PCOS) status. Methods: This cross-sectional study comprised ...
Source: Diabetology and Metabolic Syndrome - May 21, 2015 Category: Endocrinology Authors: T.G. ValderhaugJ.K. HertelN. NordstrandP.O. DaleD. HofsøJ. Hjelmesæth Source Type: research

Visceral obesity, but not metabolic syndrome, is associated with the presence of post-thrombotic syndrome
The relationship between metabolic syndrome (MetS), and the development of post-thrombotic syndrome (PTS) is currently unknown. (Source: Thrombosis Research)
Source: Thrombosis Research - May 21, 2015 Category: Hematology Authors: M. Rattazzi, E. Callegari, A. Sponchiado, S. Galliazzo, V. Pagliara, S. Villalta, P. Pauletto Source Type: research

Fo035 * high body mass index and metabolic syndrome are associated with podocyte injury in obese individuals
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 21, 2015 Category: Urology & Nephrology Authors: Veronese, F. V., Pereira, S. V., dos Santos, M., Rodrigues, P. G., do Nascimento, J. F., Timm, J. T., Zancan, R., Friedman, R. Tags: PODOCYTES Source Type: research

Fp011 * association of urinary sodium excretion with metabolic syndrome and body fat
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 21, 2015 Category: Urology & Nephrology Authors: Oh, S. Tags: ACID-BASE/NA, K, CL, URIC ACID Source Type: research

Fp248 * microalbuminuria and metabolic syndrome
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 21, 2015 Category: Urology & Nephrology Authors: Shishkin, A., Hudiakova, N. Tags: CHRONIC KIDNEY DISEASE. LAB METHODS, GFR MEASUREMENT, URINE PROTEOMICS Source Type: research

Fp457 * effect of an oral adsorbent ast-120 on glomerular and tubular injury in metabolic syndrome/diabetes rats
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 21, 2015 Category: Urology & Nephrology Authors: Aoki, R., Sekine, F., Miyazaki, S., Goto, S., Bannai, K., Yamashita, Y., Itoh, Y. Tags: DIABETES - BASIC RESEARCH Source Type: research

Fp891 * the profile of adipokines in kidney transplanted patients with metabolic syndrome
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 21, 2015 Category: Urology & Nephrology Authors: Malgorzewicz, S., Czajka, B., Dębska-Slizieł, A., Rutkowski, B. Tags: RENAL TRANSPLANTATION. CLINICAL - 1 Source Type: research

Fp892 * body composition, metabolic syndrome and kidney function;consideration from kidney transplant donors
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 21, 2015 Category: Urology & Nephrology Authors: Yoshikawa, M. Tags: RENAL TRANSPLANTATION. CLINICAL - 1 Source Type: research

Sp089 * end-stage renal disease associated with metabolic syndrome: a study of biomarkers utilizing biochip array profiling methods
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 21, 2015 Category: Urology & Nephrology Authors: Bansal, V., Hoppensteadt, D., Syed, D., Abro, S., Ahmad, S., Fareed, J. Tags: RENAL PATHOLOGY. EXPERIMENTAL AND CLINICAL Source Type: research

Nox2-dependent Insulin Resistance [Metabolism]
Inflammation and oxidative stress through the production of reactive oxygen species (ROS) are consistently associated with metabolic syndrome/type 2 diabetes. Although the role of Nox2, a major ROS-generating enzyme, is well described in host defense and inflammation, little is known about its potential role in insulin resistance in skeletal muscle. Insulin resistance induced by a high fat diet was mitigated in Nox2-null mice compared with wild-type mice after 3 or 9 months on the diet. High fat feeding increased Nox2 expression, superoxide production, and impaired insulin signaling in skeletal muscle tissue of wild-type m...
Source: Journal of Biological Chemistry - May 21, 2015 Category: Chemistry Authors: Souto Padron de Figueiredo, A., Salmon, A. B., Bruno, F., Jimenez, F., Martinez, H. G., Halade, G. V., Ahuja, S. S., Clark, R. A., DeFronzo, R. A., Abboud, H. E., El Jamali, A. Tags: Cell Biology Source Type: research

The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.
In this study, the XO inhibitor febuxostat was administered to two types of NASH model mice. Febuxostat exerted a strong protective effect against NASH development induced by a high fat diet containing trans fatty acid (HFDT). In contrast, methionine choline-deficient (MCD)-diet-induced NASH development not accompanied by hyperuricemia showed no UA normalization, suggesting that the ameliorating effect of febuxostat occurs via the normalization of hyperuricemia itself and/or accompanying molecular mechanism(s) such as oxidative stress. In the HFDT-fed mice, hyperuricemia, elevated alanine aminotransferase and increased Tun...
Source: Am J Physiol Gastroi... - May 21, 2015 Category: Gastroenterology Authors: Nakatsu Y, Seno Y, Kushiyama A, Sakoda H, Fujishiro M, Katasako A, Mori K, Matsunaga Y, Fukushima T, Kanaoka R, Yamamotoya T, Kamata H, Asano T Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Metabolic Syndrome: Does it Differ Between Women and Men?
Abstract Cardiovascular disease represents a massive healthcare burden worldwide. Gender differences in the pathophysiology, presentation and prognosis of cardiovascular disease have been described in the literature. Metabolic syndrome, characterized by a cluster of metabolic abnormalities is associated with increased risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. With the global obesity epidemic, the prevalence of metabolic syndrome is rising rapidly in the developed as well as developing world. However, there is considerable variation in the prevalence based on geography, age, sex ...
Source: Cardiovascular Drugs and Therapy - May 20, 2015 Category: Cardiology Source Type: research

Circulating fibroblast growth factor 23 (FGF23) levels are associated with metabolic disturbances and fat distribution but not cardiovascular risk in HIV-infected patients
Conclusions FGF23 levels are increased in HIV-1-infected patients, especially in those with HALS, and this increase is associated with dyslipidaemia, insulin resistance, metabolic syndrome, fat distribution and parameters of inflammation. FGF23 is not associated with cardiovascular risk when age is taken into account. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 20, 2015 Category: Microbiology Authors: Domingo, P., Lamarca, M. K., Gallego-Escuredo, J. M., Torres, F., Domingo, J. C., Villarroya, J., Gutierrez, M. d. M., Mateo, M. G., Vidal, F., Villarroya, F., Giralt, M. Tags: Original research Source Type: research

Cardiovascular autonomic tone relation to metabolic parameters and hsCRP in normoglycemia and prediabetes
The aim of the study was to evaluate cardiovascular autonomic function (CAF) at different stages of obesity and in the presence of metabolic syndrome (MetS), and its association with metabolic parameters and hsCRP in subjects with normal glucose tolerance (NGT) and prediabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - May 20, 2015 Category: Endocrinology Authors: Rumyana Dimova, Tsvetalina Tankova, Nevena Chakarova, Greta Groseva, Lilia Dakovska Source Type: research

E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish
Conclusion: We discovered that the e2f8–fabp3 axis is important in the promotion of hepatic steatosis in DIO-zebrafish. The combination of transcriptome and proteome analyses using the disease model zebrafish allow identification of novel pathways involved in human diseases. (Source: Nutrition and Metabolism)
Source: Nutrition and Metabolism - May 20, 2015 Category: Nutrition Authors: Yasuhito ShimadaShisei KuninagaMichiko AriyoshiBeibei ZhangYasuhiko ShiinaYoshinori TakahashiNoriko UmemotoYuhei NishimuraHiroyuki EnariToshio Tanaka Source Type: research

Increased Cardiovascular Mortality in Subjects With Metabolic Syndrome Is Largely Attributable to Diabetes and Hypertension in 159 971 Korean Adults.
CONCLUSIONS: The presence of MetS increased the risk for all-cause mortality in women and the risk for CVD mortality in total population. These increased HR attributed to the pre-existing diabetes or hypertension in this population. PMID: 25993638 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - May 20, 2015 Category: Endocrinology Authors: Sung KC, Rhee EJ, Ryu S, Kim BJ, Kim BS, Lee WY, Oh KW, Bum Kim Y, Chung PW, Kim H, Byrne CD, Lee KB, Park SW Tags: J Clin Endocrinol Metab Source Type: research

Cytokine and growth factor profiling in patients with the metabolic syndrome.
In conclusion, our findings demonstrate that patients with the MetS had an altered blood cytokine and growth factor profile that may partially account for its adverse clinical outcomes. Further prospective studies in larger multi-centre settings are required to unravel the role and association of the emerging biomarkers with the MetS and their implication in therapeutic intervention. PMID: 25990566 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - May 20, 2015 Category: Nutrition Authors: Mirhafez SR, Pasdar A, Avan A, Esmaily H, Moezzi A, Mohebati M, Meshkat Z, Mehrad-Majd H, Eslami S, Rahimi HR, Ghazavi H, Ferns GA, Ghayour-Mobarhan M Tags: Br J Nutr Source Type: research

The Metabolic Syndrome: The future is now
This article is protected by copyright. All rights reserved. (Source: Acta Physiologica)
Source: Acta Physiologica - May 19, 2015 Category: Physiology Authors: S. Reuter, R. Mrowka Tags: Editorial Source Type: research

Influence of anti‐hypertensive therapy on cerebral perfusion in patients with metabolic syndrome: relationship with cognitive function and 24‐hour arterial blood pressure monitoring
ConclusionThe study showed the presence of diffuse disturbances in cerebral perfusion is associated with cognitive disorders in patients with metabolic syndrome. Combination anti‐hypertensive treatment exerts beneficial effects on the 24‐hours blood pressure profile, increases cerebral blood flow, and improves cognitive function in patients with MetS.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - May 19, 2015 Category: Cardiology Authors: Nataliya Y. Efimova, Vladimir I. Chernov, Irina Y. Efimova, Yuri B. Lishmanov Tags: Original Research Article Source Type: research

Associations between dietary intake and the presence of the metabolic syndrome in patients with non‐alcoholic fatty liver disease
ConclusionsLow refined grain and red meat intake, high whole grain intake and high adherence to the MD were associated with lower odds of the MetS in NAFLD patients. (Source: Journal of Human Nutrition and Dietetics)
Source: Journal of Human Nutrition and Dietetics - May 19, 2015 Category: Nutrition Authors: M. Georgoulis, M. D. Kontogianni, A. Margariti, D. Tiniakos, E. Fragopoulou, R. Zafiropoulou, G. Papatheodoridis Tags: Research Paper Source Type: research

Genetic determinants of quantitative traits associated with cardiovascular disease risk
Publication date: Available online 15 May 2015 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Božena Smolková , Stefano Bonassi , Verona Buociková , Mária Dušinská , Alexandra Horská , Daniel Kuba , Zuzana Džupinková , Katarína Rašlová , Juraj Gašparovič , Ivan Slíž , Marcello Ceppi , Branislav Vohnout , Ladislava Wsólová , Katarína Volkovová Established risk factors for cardiovascular diseases (CVD) may be moderated by genetic variants. In 2403 unrelated individuals from general practice (mean age 40.5 years), we evaluated the influence of 15 variants in 12 ca...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - May 19, 2015 Category: Cytology Source Type: research

Prevalence of the Metabolic Syndrome in the United States, 2003-2012
This population epidemiology study uses NHANES data to report trends in the prevalence of the metabolic syndrome in US adults between 2003 and 2012. (Source: JAMA)
Source: JAMA - May 19, 2015 Category: Journals (General) Source Type: research

The theta-defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats.
Abstract Inflammation is implicated in metabolic abnormalities in obesity and type 2 diabetes. Because theta-defensins (θ-defensins) have anti-inflammatory activities, we tested whether RTD-1, a θ-defensin, improves metabolic conditions in diet-induced obesity (DIO). DIO was induced by high-fat feeding in Obese Prone CD rats from four weeks of age. Starting at age 10 weeks, the DIO rats were treated with saline or RTD-1 for 4 or 8 weeks. DIO rats gained more weight than low-fat fed controls. RTD-1 treatment did not alter body weight or calorie intake in DIO rats. Plasma glucose, FFA, triglyceride (TG), and insuli...
Source: Am J Physiol Endocri... - May 19, 2015 Category: Endocrinology Authors: Oh YT, Tran D, Buchanan TA, Selsted ME, Youn JH Tags: Am J Physiol Endocrinol Metab Source Type: research

Daily Sodium and Potassium Excretion Can Be Estimated by Scheduled Spot Urine Collections
Conclusion: Four scheduled spot urine samples can be used as a convenient method for estimation of 24-hour sodium or potassium excretion.Nephron 2015;130:35-40 (Source: Nephron)
Source: Nephron - May 18, 2015 Category: Urology & Nephrology Source Type: research

Clozapine use and sedentary lifestyle as determinants of metabolic syndrome in outpatients with schizophrenia
Nordic Journal of Psychiatry, Ahead of Print. (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - May 18, 2015 Category: Psychiatry Tags: article Source Type: research

U-shaped relationships between sleep duration and metabolic syndrome and metabolic syndrome components in males: a prospective cohort study
• The relationship between sleep duration and MS was U-shaped in general population.• Short and long sleep durations increased the risk of MS and hyperglycemia in males.• Males who slept > 8 h were at higher risk for hypertriglyceridemia.• Females who slept < 7 h and > 9 h were associated with incident hypertension. (Source: Sleep Medicine)
Source: Sleep Medicine - May 18, 2015 Category: Sleep Medicine Authors: Xue Li, Liqun Lin, Lin Lv, Xiuyu Pang, Shanshan Du, Wei Zhang, Guanqiong Na, Hao Ma, Qiao Zhang, Shuo Jiang, Haoyuan Deng, Tianshu Han, Changhao Sun, Ying Li Tags: Original Article Source Type: research

Exenatide QW integrated safety analysis
MacConell L, Gurney K, Malloy J, Zhou M, Kolterman O (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 17, 2015 Category: Endocrinology Source Type: research

Comparison between CDC and WHO BMI z-score and their relation with metabolic risk markers in Northern Portuguese obese adolescents.
CONCLUSIONS: A significant difference between the two BMIzsc regarding their association with MS and IR was not clear, being these associations weaker in younger individuals. PMID: 25969698 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - May 17, 2015 Category: Endocrinology Authors: Nascimento H, Catarino C, Mendonça D, Oliveira P, Alves AI, Medeiros AF, Pereira PR, Rêgo C, Mansilha HF, Aires L, Mota J, Quintanilha A, Santos-Silva A, Belo L Tags: Diabetol Metab Syndr Source Type: research

An Update of Liver Transplantation for Nonalcoholic Steatohepatitis
Abstract Nonalcoholic steatohepatitis (NASH), obesity, and the metabolic syndrome are highly prevalent before and after liver transplantation, with NASH currently the second most common indication. This review considers established and new aspects of liver transplantation for NASH. NASH is one of many sequelae of obesity and most frequently occurs on a background of the metabolic syndrome. While recurrence of steatosis is common, recurrence of NASH with advanced stages of fibrosis is unusual, with graft loss due to recurrence of NASH cirrhosis occurring with a frequency of less than 5 %. In contrast, the componen...
Source: Current Hepatitis Reports - May 17, 2015 Category: Infectious Diseases Source Type: research

Shift work and its association with metabolic disorders
Although the health burden of shift work has not been extensively studied, evidence suggests that it may affect the metabolic balance and cause obesity and other metabolic disorders. Sleep deprivation, circadian desynchronization and behavioral changes in diet and physical activity are among the most commonly mentioned factors in studies of the association between night work and metabolic disorders. Individual adaptation to night work depends greatly on personal factors such as family and social life, but occupational interventions may also make a positive contribution to the transition to shift work, such as exposure to b...
Source: Diabetology and Metabolic Syndrome - May 17, 2015 Category: Endocrinology Authors: Maria BrumFábio FilhoClaudia SchnorrGustavo Borchardt BottegaTiciana Rodrigues Source Type: research

Efficacy of dipeptidyl peptidase-4 inhibitor linagliptin in patients with type 2 diabetes undergoing hemodialysis
Conclusion: Linagliptin can decrease serum levels of oxLDL in patients with type 2 diabetes undergoing HD independent of its glucose-lowering effect. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 17, 2015 Category: Endocrinology Authors: Yuichi TerawakiTakashi NomiyamaHiroyuki TakahashiYoko TsutsumiKunitaka MuraseRyoko NagaishiMakito TanabeTadachika KudoKunihisa KobayashiTetsuhiko YasunoHitoshi NakashimaToshihiko Yanase Source Type: research

Assessment of human lymphocyte proliferation associated with metabolic syndrome
Conclusions The increased lymphocyte proliferative response to insulin in patients with MetS found in this study suggests a role of the lymphocyte response to insulin in the pathophysiology of MetS. This response may be used as an immuno-biological marker for MetS, although further studies to evaluate its clinical usefulness need to be conducted. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 16, 2015 Category: Endocrinology Source Type: research

Differences in physical activity domains, guideline adherence, and weight history between metabolically healthy and metabolically abnormal obese adults: a cross-sectional study
Background: Despite the accepted health consequences of obesity, emerging research suggests that a significant segment of adults with obesity are metabolically healthy (MHO). To date, MHO individuals have been shown to have higher levels of physical activity (PA), but little is known about the importance of PA domains or the influence of weight history compared to their metabolically abnormal (MAO) counterpart.ObjectiveTo evaluate the relationship between PA domains, PA guideline adherence, and weight history on MHO. Methods: Pooled cycles of the National Health and Nutritional Examination Survey (NHANES) 1999–2006 (≥2...
Source: International Journal of Behavioral Nutrition and Physical Activity - May 16, 2015 Category: Nutrition Authors: Thirumagal KanagasabaiNiels ThakkarJennifer KukJames ChurillaChris Ardern Source Type: research

Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia
In this study, we hypothesized that CI (by MLD28170) would decrease myocardial apoptosis in the same model. (Source: Surgery)
Source: Surgery - May 16, 2015 Category: Surgery Authors: Brittany A. Potz, Ashraf A. Sabe, Nassrene Y. Elmadhun, Jun Feng, Yuhong Liu, Hunter Mitchell, Peter Quesenberry, M. Ruhul Abid, Frank W. Sellke Tags: Society of University Surgeons Source Type: research

A worm of one's own: how helminths modulate host adipose tissue function and metabolism.
Abstract Parasitic helminths have coexisted with human beings throughout time. Success in eradicating helminths has limited helminth-induced morbidity and mortality but is also correlated with increasing rates of 'western' diseases, including metabolic syndrome and type 2 diabetes. Recent studies in mice describe how type 2 immune cells, traditionally associated with helminth infection, maintain adipose tissue homeostasis and promote adipose tissue beiging, protecting against obesity and metabolic dysfunction. Here, we review these studies and discuss how helminths and helminth-derived molecules may modulate these ...
Source: Trends in Parasitology - May 16, 2015 Category: Parasitology Authors: Guigas B, Molofsky AB Tags: Trends Parasitol Source Type: research