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Metabolic Syndrome

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Association of dietary vitamin D, serum 25-hydroxyvitamin D, insulin-like growth factor-1 concentrations and components of metabolic syndrome among Iranian women.
CONCLUSION: Our findings show that vitamin D status was related to FBS, HDL-C and triglyceride concentration; hence, with regard to findings of previous studies it seems that vitamin D is related to components of MetS. However, to determine the role of vitamin D status and IGF-1 in the development MetS and related components, further longitudinal studies and randomized clinical trials should be prescribed. PMID: 25221762 [PubMed] (Source: Biomed Res)
Source: Biomed Res - September 21, 2014 Category: Research Authors: Vasmehjani AA, Paknahad Z, Maracy MR Tags: Adv Biomed Res Source Type: research

Dramatic escalation in metabolic syndrome and cardiovascular risk in a Chinese population experiencing rapid economic development
Cardiovascular (CVD) risk escalated dramatically in the Chinese population between 2002 and 2010, with the escalation related to the pace of economic development, which led to accelerating changes in nutrition, lifestyle, and socio-economic status. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - September 20, 2014 Category: Consumer Health News Authors: Xiang LaoWen MaTanja SobkoYong ZhangYan XuXiao XuDong YuShao NieQiu CaiXiao WeiLiang XiaMartin Wong Source Type: research

Renal Denervation: Transition From Pathophysiology to Clinical Practice
Resistant hypertension, defined as failure to reach blood pressure (BP) goals despite treatment with ≥3 antihypertensive agents, one of which is a diuretic, bears a significant risk of cardiovascular complications. Strong evidence exists, implicating the overactivation of the sympathetic nervous system (SNS) in the pathogenesis of resistant hypertension through complex neurohormonal interactions. Renal denervation is a novel attractive option to achieve adequate blockade of the sympathetic system, with subsequent BP reductions in patients with resistant hypertension. Data have shown promising results regarding the effic...
Source: Angiology - September 18, 2014 Category: Cardiology Authors: Gossios, T. D., Ziakas, A., Doumas, M., Katsiki, N., Petroglou, D., Kouparanis, A., Lillis, L., Karvounis, H. Tags: Reviews Source Type: research

Editorial: metabolic syndrome delays HBeAg seroclearance in Chinese patients with hepatitis B
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 17, 2014 Category: Drugs & Pharmacology Authors: M. Danta, D. Bradshaw Tags: Invited Editorials Source Type: research

Editorial: metabolic syndrome delays HBeAg seroclearance in Chinese patients with hepatitis B – authors' reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 17, 2014 Category: Drugs & Pharmacology Authors: J. Hsiang, G. L.‐H. Wong, H. L.‐Y. Chan, V. W.‐S. Wong Tags: Invited Editorial Source Type: research

Prevalence and correlates of obstructive sleep apnoea among patients with and without HIV infection
ConclusionsHIV‐infected patients are less likely to receive a diagnosis of OSA. Future studies are needed to determine whether the lower prevalence of OSA diagnoses in HIV‐infected patients is attributable to decreased screening and detection or to a truly decreased likelihood of OSA in the setting of HIV infection. (Source: HIV Medicine)
Source: HIV Medicine - September 17, 2014 Category: Infectious Diseases Authors: KM Kunisaki, KM Akgün, DA Fiellin, CL Gibert, JW Kim, D Rimland, MC Rodriguez‐Barradas, HK Yaggi, K Crothers Tags: Original Research Source Type: research

Magnesium in CKD: more than a calcification inhibitor?
Abstract Magnesium fulfils important roles in multiple physiological processes. Accordingly, a tight regulation of magnesium homeostasis is essential. Dysregulated magnesium serum levels, in particular hypomagnesaemia, are common in patients with chronic kidney disease (CKD) and have been associated with poor clinical outcomes. In cell culture studies as well as in clinical situations magnesium levels were associated with vascular calcification, cardiovascular disease and altered bone-mineral metabolism. Magnesium has also been linked to diseases such as metabolic syndrome, diabetes, hypertension, fatigue and depre...
Source: Journal of Nephrology - September 17, 2014 Category: Urology & Nephrology Authors: Floege J Tags: J Nephrol Source Type: research

The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in southwest of Iran
Conclusions: Women who had all three components of the syndrome showed the highest level of metabolic disturbances indicating that metabolic screening of the severest phenotype of PCOS may be necessary. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - September 16, 2014 Category: Epidemiology Authors: Fahimeh Ramezani TehraniHomeira RashidiMahnaz Bahri KhomamiMaryam TohidiFereidoun Azizi Source Type: research

Metabolic syndrome in the prediction of cardiovascular events: the potential additive role of hsCRP and adiponectin
Conclusions MS is an important predictor of cardiovascular events and is most harmful in combination with high plasma hsCRP. The clustering of components is especially harmful. (Source: European Journal of Preventive Cardiology)
Source: European Journal of Preventive Cardiology - September 16, 2014 Category: Cardiology Authors: Santaniemi, M., Ukkola, O., Malo, E., Bloigu, R., Kesaniemi, Y. A. Tags: Original scientific papers Source Type: research

Prevalence and predictors of metabolic abnormalities in Chinese women with PCOS: a cross- sectional study
Conclusions: The risk factors of the metabolic syndrome and insulin resistance were BMI and FAI for PCOS women, respectively. The decrease of SHBG level was also a risk factor for insulin resistance in both PCOS and metabolic disturbance. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - September 16, 2014 Category: Endocrinology Authors: Rong LiGeng YuDongzi YangShangwei LiShulan LuXiaoke WuZhaolian WeiXueru SongXiuxia WangShuxin FuJie Qiao Source Type: research

Discovery of new non‐steroidal Farnesoid X Receptor (FXR) modulators through 3D shape similarity search and structure‐based virtual screening
This article is protected by copyright. All rights reserved. The results of transient transfection experiments showed that two compounds can inhibit FXR functions in a concentration‐dependent manner with IC50 of 8.39 and 6.53 μM, respectively. Both of them can comfortably fit in the FXR binding pocket. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - September 16, 2014 Category: Biology Authors: Lei Wang, Pei Si, Yayun Sheng, Yingjie Chen, Ping Wan, Xu Shen, Yun Tang, Lili Chen, Weihua Li Tags: Research Letter Source Type: research

A Possible Role of Serum Uric Acid as a Marker of Metabolic Syndrome
ConclusionOur results indicate that an increased level of SUA, even within the normal range, is associated with future development of MetS in healthy middle‐aged men. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - September 16, 2014 Category: Internal Medicine Authors: Yu‐Ji Lee, Seong Cho, Sung Rok Kim Tags: Original Article Source Type: research

Sex hormone-binding globulin (SHBG) gene expression and insulin resistance.
Conclusions: Fat accumulation in liver and IR are important determinants of SHBG gene expression and thereby circulating SHBG levels that are perhaps mediated through effects on the transcription factor HNF4α. These findings provide a potential mechanism to explain why low SHBG predicts the development of T2DM. PMID: 25226295 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 16, 2014 Category: Endocrinology Authors: Winters SJ, Gogineni J, Karegar M, Scoggins C, Wunderlich CA, Baumgartner R, Ghooray DT Tags: J Clin Endocrinol Metab Source Type: research

Exercise-mediated vasodilation in human obesity and metabolic syndrome: effect of acute ascorbic acid infusion
We examined the time to achieve steady-state FVC (mean response time, MRT) and the rise in FVC from rest to steady-state exercise (, exercise – rest) before and during acute AA infusion. The MRT (P = 0.26) and steady-state vasodilator responses to exercise (FVC, P = 0.31) were not different between groups. Intra-arterial infusion of AA resulted in a significant increase in plasma total antioxidant capacity (174 ± 37%). AA infusion did not alter MRT or steady-state FVC in any group (P = 0.90 and P = 0.85, respectively). Interestingly, higher levels of C-reactive protein predicted longer MRT (r = 0.52, P < 0....
Source: AJP: Heart and Circulatory Physiology - September 15, 2014 Category: Cardiology Authors: Limberg, J. K., Kellawan, J. M., Harrell, J. W., Johansson, R. E., Eldridge, M. W., Proctor, L. T., Sebranek, J. J., Schrage, W. G. Tags: CALL FOR PAPERS Source Type: research

Prevalence of metabolic syndrome in human immunodeficiency virus - infected patients from the South-West region of Cameroon, using the adult treatment panel III criteria.
CONCLUSIONS: In this study, HAART but not HIV disease plays a significant role in the development of MS. The metabolic complications as a result of treatment with HAART may predispose HIV patients to developing cardiovascular diseases and diabetes, in spite of improvements in morbidity and mortality conferred by immune reconstitution as a result of HAART treatment. PMID: 25197324 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 14, 2014 Category: Endocrinology Authors: Mbunkah HA, Meriki HD, Kukwah AT, Nfor O, Nkuo-Akenji T Tags: Diabetol Metab Syndr Source Type: research

A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy
Metabolic syndrome includes glucose intolerance and dyslipidemia, both of which are strong risk factors for developing diabetes and atherosclerotic cardiovascular diseases. Recently, multiple groups independently studied a previously uncharacterized gene, officially named C19orf80 (human) and Gm6484 (mouse), but more commonly known as RIFL, Angptl8, betatrophin and lipasin. Both exciting and conflicting results have been obtained, and significant controversy is ongoing. Accumulating evidence from genome wide association studies and mouse genetic studies convincingly shows that lipasin is involved in lipid regulation. Howev...
Source: Cardiovascular Diabetology - September 13, 2014 Category: Cardiology Authors: Ren ZhangAbdul Abou-Samra Source Type: research

Preoperative serum h-FABP concentration is associated with postoperative incidence of acute kidney injury in patients undergoing cardiac surgery
Conclusions: We found a correlation between preoperative serum h-FABP and the postoperative incidence of AKI. Our results suggest a potential role for h-FABP as a biomarker for AKI in cardiac surgery. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - September 12, 2014 Category: Cardiology Authors: Mehmet OezkurArmin GorskiJennifer PeltzMartin WagnerMaria LazariotouChristoph SchimmerPeter HeuschmannRainer Leyh Source Type: research

Metabolic syndrome as an indicator of high cardiovascular risk in patients with diabetes: Analyses based on Korea National Health and Nutrition Examination Survey (KNHANES) 2008
Conclusions: The efficacy of MS as a screening tool for high CVD risk may be limited in DM patients, and conventional risk factors such as LDL may be more important. (Source: BioMed Central)
Source: BioMed Central - September 12, 2014 Category: Journals (General) Authors: Sang Youl RheeSo Young ParkJin Kyung HwangJung Il SonSang Ouk ChinYoung Seol KimJeong-taek Woo Source Type: research

Association between low 25-hydroxyvitamin D, insulin resistance and arterial stiffness in nondiabetic women with systemic lupus erythematosus.
CONCLUSION: Low 25(OH)D levels were found to be associated with increased IR in nondiabetic women with SLE independently of BMI. Low 25(OH)D levels, but not IR, could be associated with increased arterial stiffness in these patients. PMID: 25216653 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 12, 2014 Category: Rheumatology Authors: Sabio J, Vargas-Hitos J, Martinez-Bordonado J, Navarrete-Navarrete N, Díaz-Chamorro A, Olvera-Porcel C, Zamora M, Jiménez-Alonso J Tags: Lupus Source Type: research

Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction
Conclusions: Our data indicate that combined treatment exerts more beneficial effects on lowering BP and improving vascular lesions. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 11, 2014 Category: Biomedical Science Authors: Kong, X., Ma, M.-z., Qin, L., Zhang, Y., Li, X.-y., Wang, G.-d., Su, Q., Zhang, D.-y. Tags: Articles Source Type: research

Association Between the Metabolic Syndrome, Its Individual Components, and Unprovoked Venous Thromboembolism: Results of a Patient-Level Meta-Analysis.
CONCLUSIONS: Case-control but not prospective cohort studies support an association between MetS and VTE. Abdominal adiposity is a strong risk factor for VTE. PMID: 25212233 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 11, 2014 Category: Cardiology Authors: Ageno W, Di Minno MN, Ay C, Jang MJ, Hansen JB, Steffen LM, Vayà A, Rattazzi M, Pabinger I, Oh D, Di Minno G, Braekkan SK, Cushman M, Bonet E, Pauletto P, Squizzato A, Dentali F Tags: Arterioscler Thromb Vasc Biol Source Type: research

Circulating osteoprotegerin is increased in the metabolic syndrome and associates with subclinical atherosclerosis and coronary arterial calcification.
CONCLUSIONS: This study shows that OPG may potentially be a biomarker for cardiovascular risk/damage in the MS and identifies adipose tissue as a potential source of OPG. PMID: 25218813 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - September 11, 2014 Category: Biochemistry Authors: de Ciriza CP, Moreno M, Restituto P, Bastarrika G, Simón I, Colina I, Varo N Tags: Clin Biochem Source Type: research

Estimating the glomerular filtration rate in the Spanish working population: chronic kidney disease prevalence and its association with risk factors
Conclusions:The CKD-EPI formula, calculated on the basis of two reported blood samples, may provide the most specific definition of CKD. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Does metabolic syndrome increase erectile dysfunction and lower urinary tract symptoms.
CONCLUSION: We found that metabolic syndrome did not significantly affect LUTS but could significantly contribute to ED. We therefore feel patients presenting with ED complaints should also be carefully evaluated for MS.&nbsp; PMID: 25194083 [PubMed - in process] (Source: Urology Journal)
Source: Urology Journal - September 10, 2014 Category: Urology & Nephrology Authors: Coban S, Cander S, Altuner MS, Keles I, Gul OO Tags: Urol J Source Type: research

Obesity, insulin resistance and comorbidities ? Mechanisms of association
Overall excess of fat, usually defined by the body mass index, is associated with metabolic (e.g. glucose intolerance, type 2 diabetes mellitus (T2DM), dyslipidemia) and non-metabolic disorders (e.g. neoplasias, polycystic ovary syndrome, non-alcoholic fat liver disease, glomerulopathy, bone fragility etc.). However, more than its total amount, the distribution of adipose tissue throughout the body is a better predictor of the risk to the development of those disorders. Fat accumulation in the abdominal area and in non-adipose tissue (ectopic fat), for example, is associated with increased risk to develop metabolic and non...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research

Insulin resistance and components of metabolic syndrome, analysis by gender and stage of adolescence
Conclusions: Insulin resistance is associated with inadequate body composition, in biochemical levels and lifestyle, being the factors associated different in each phase of adolescence. Arq Bras Endocrinol Metab. 2014;58(6):610-8 (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research

Dose-Dependent Arterial Destiffening and Inward Remodeling After Olmesartan in Hypertensives With Metabolic Syndrome [Clinical Trial]
Whether angiotensin receptor blockers can dose-dependently remodel the arterial wall during long-term treatment has been largely debated. In this phase III, multicenter, randomized, double-blind, parallel-group study, 133 subjects with hypertension and metabolic syndrome were assigned to olmesartan, either 20 mg (n=44), 40 mg (n=42), or 80 mg (n=47) once a day, according to a force titration design during a 1-year period. Office blood pressure, 24-hour blood pressure, aortic stiffness (carotid-femoral pulse wave velocity), and carotid parameters were measured at baseline, 24 weeks, and 52 weeks. Pulse wave velocity signifi...
Source: Hypertension - September 10, 2014 Category: Cardiology Authors: Laurent, S., Boutouyrie, P., on behalf of the Vascular Mechanism Collaboration Tags: Remodeling, Clinical Studies, Other Treatment, Other imaging Clinical Trial Source Type: research

Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome [Oxidative Stress]
This study sought to identify the source of tissue oxidative stress in RVLM and their roles in neural mechanism of hypertension associated with MetS. Adult normotensive rats subjected to a high-fructose diet for 8 weeks developed metabolic traits of MetS, alongside increases in sympathetic vasomotor activity and blood pressure. In RVLM of these MetS rats, the tissue level of reactive oxygen species was increased, nitric oxide (NO) was decreased, and mitochondrial electron transport capacity was reduced. Whereas the protein expression of neuronal NO synthase (nNOS) or protein inhibitor of nNOS was increased, the ratio of nN...
Source: Hypertension - September 10, 2014 Category: Cardiology Authors: Wu, K. L. H., Chao, Y.-M., Tsay, S.-J., Chen, C. H., Chan, S. H. H., Dovinova, I., Chan, J. Y. H. Tags: Animal models of human disease, Other hypertension Oxidative Stress Source Type: research

Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome
Conclusions: Elevated afamin concentrations are associated with the presence of metabolic syndrome in young women and may potentially serve as an independent predictor for the development of metabolic syndrome in at-risk women, especially those with IR. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 10, 2014 Category: Endocrinology Authors: Beata SeeberElisabeth MorandellFabian LungerLudwig WildtHans Dieplinger Source Type: research

Epigenetics in the development, modification, and prevention of cardiovascular disease.
Abstract Epigenetics has major relevance to all disease processes; cardiovascular (CV) disease and its related conditions are no exception. Epigenetics is defined as the study of heritable alterations in gene expression, or cellular phenotype, and goes far beyond a pure genetic approach. A more precise definition is that epigenetics represents all the meiotically and mitotically inherited changes in gene expression that are not encoded on the deoxyribonucleic acid (DNA) sequence itself. Major epigenetic mechanisms are modifications of histone proteins in chromatin and DNA methylation (which does not alter the DNA s...
Source: Molecular Biology Reports - September 10, 2014 Category: Molecular Biology Authors: Whayne TF Tags: Mol Biol Rep Source Type: research

Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome.
CONCLUSIONS: Elevated afamin concentrations are associated with the presence of metabolic syndrome in young women and may potentially serve as an independent predictor for the development of metabolic syndrome in at-risk women, especially those with IR. PMID: 25208973 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - September 10, 2014 Category: Reproduction Medicine Authors: Seeber B, Morandell E, Lunger F, Wildt L, Dieplinger H Tags: Reprod Biol Endocrinol Source Type: research

Alcoholic and non-alcoholic steatohepatitis.
Abstract This paper is based upon the "Charles Lieber Satellite Symposia" organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014. The present review includes pre-clinical, translational and clinical research that characterize alcoholic liver disease (ALD) and non-alcoholic steatohepatitis (NASH). In addition, a literature search in the discussed area was performed. Strong clinical and experimental evidence lead to recognition of the key toxic role of alcohol in the pathogenesis of ALD. The liver biopsy can confirm the etiology of NASH or alcoholic steatohepatitis (...
Source: Experimental and Molecular Pathology - September 10, 2014 Category: Pathology Authors: Neuman MG, French SW, French BA, Seitz HK, Cohen LE, Mueller S, Osna NA, Kharbanda KK, Seth D, Bautista A, Thompson KJ, McKillop IH, Kirpich IA, McClain CJ, Bataller R, Nanau RM, Shen H, Tillman B, Li J, Liu H, Thomas PG, Ganesan M, Malnick S Tags: Exp Mol Pathol Source Type: research

O-GlcNAc modification is associated with insulin sensitivity in the whole blood of healthy young adult males
Conclusions: Results indicate that O-GlcNAc has a greater sensitivity to metabolic status compared to HbA1c in this population. O-GlcNAc has the potential to serve as a screening tool for predicting future metabolic disturbances in a young healthy adult population free of any clinically relevant pathologies. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - September 9, 2014 Category: Epidemiology Authors: Jason P MyslickiJane ShearerDustin S HittelCurtis C HugheyDarrell D Belke Source Type: research

Prevalence and characteristics of metabolic syndrome in South‐East Asian psoriatic patients: A case–control study
In conclusion, the prevalence of HBP, hyperglycemia and abdominal obesity was significantly higher in cases than in controls. (Source: The Journal of Dermatology)
Source: The Journal of Dermatology - September 9, 2014 Category: Dermatology Authors: Chayada Kokpol, Wichai Aekplakorn, Natta Rajatanavin Tags: Original Article Source Type: research

The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) in prostate cancer patients undergoing androgen deprivation therapy: study protocol for a randomized controlled trial
DiscussionFindings from this study will establish the feasibility and preliminary efficacy of an innovative lifestyle intervention designed to promote progressively independent self-regulated exercise and dietary behavior change in the treatment of patients with prostate cancer undergoing ADT.Trial registration: NCT02050906 (Source: Trials)
Source: Trials - September 9, 2014 Category: Journals (General) Authors: Brian FochtAlexander LucasElizabeth GraingerChristina SimpsonJennifer Thomas-AhnerSteven Clinton Source Type: research

Patterns, levels and correlates of self-reported physical activity in urban black Soweto women
Conclusions: The findings of this study show that the majority of urban dwelling black South African women are classified as physically active despite a high prevalence of obesity and metabolic disease risk factors. Sitting time had detrimental effects on both triglyceride levels and diastolic blood pressure whilst total physical activity attenuated fasting insulin levels. As walking for travel is a major contributor to physical activity, future research should attempt to determine whether the intensity of this activity plays a role in the prevention of cardiometabolic diseases. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - September 8, 2014 Category: Consumer Health News Authors: Philippe GradidgeNigel CrowtherEsnat ChirwaShane NorrisLisa Micklesfield Source Type: research

Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study.
CONCLUSION: Our results suggest that serum AFP levels are significantly associated with FLD and that AFP acts as a cofactor, but not as an independent factor, for FLD. PMID: 25206293 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Xu P, Xu CF, Wan XY, Yu CH, Shen C, Chen P, Xu GY, Li YM Tags: World J Gastroenterol Source Type: research

Novel predictive models for metabolic syndrome risk: a "big data" analytic approach.
Conclusions The platform generated individualized insights using available heterogeneous data within 3 months. The accuracy and short speed to insight with this type of analytic platform allowed Aetna to develop targeted cost-effective care management programs for individuals with or at risk for metabolic syndrome. PMID: 25180505 [PubMed - in process] (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - September 6, 2014 Category: Health Management Authors: Steinberg GB, Church BW, McCall CJ, Scott AB, Kalis BP Tags: Am J Manag Care Source Type: research

Gene mutations in hepatocellular adenomas
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - September 6, 2014 Category: Pathology Authors: Marie Birkvig Raft, Ernö Natan Jørgensen, Ben Vainer Tags: Review Source Type: research

Cardiovascular risk factors and total serum antioxidant capacity in healthy men and in men with coronary heart disease.
Abstract Whether the incidence of coronary heart disease (CHD) is related to a decrease in total antioxidant capacity (TAC) has not yet been completely clarified. We assessed TAC of blood serum in a group of 163 men with CHD aged 34.8-77.0 years and in 163 age-matched peers without CHD. Two spectrophotometric methods were applied to assess TAC: ferric reducing ability of serum (TAC-FRAS) and 2.2-diphenyl-1-picryl-hydrazyl (TAC-DPPH) tests. In the CHD group, multivariate analysis revealed that uric acid (UA), triglycerides, and systolic blood pressure contributed independently to the TAC-FRAS variance. TAC-DPPH was ...
Source: Biomed Res - September 5, 2014 Category: Research Authors: Gawron-Skarbek A, Chrzczanowicz J, Kostka J, Nowak D, Drygas W, Jegier A, Kostka T Tags: Biomed Res Int Source Type: research

G.P.206: Consequences of dietary challenge and aging on macroautophagy in Myf5+ cells and muscle
Macroautophagy (MA) maintains protein and organelle quality control and energy balance, and it has also been shown to play regulatory and developmental roles in various tissues. In differentiated skeletal muscle, inhibition of MA leads to degenerative muscle loss and decreases force production. Myogenic factor 5 positive (Myf5+) progenitor cells give rise to skeletal muscle and satellite cells, and accordingly, blocking MA in mouse Myf5+ cells using a conditional autophagy gene 7 (Atg7) knockout decreases myofiber size, perturbs muscle Akt signaling and promotes glucose intolerance. These results suggest that MA in Myf5+ i...
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: J. Sarparanta, N. Martinez-Lopez, S. Sahu, R. Singh Source Type: research

End‐stage methotrexate‐related liver disease is rare and associated with features of the metabolic syndrome
ConclusionsThe United States population burden of end‐stage methotrexate‐related liver disease is likely to be exceedingly small, suggesting the need for reappraisal of current hepatotoxicity surveillance guidelines. The risk factor profile of methotrexate‐related liver disease supports the notion that it may share a common pathogenesis with NASH. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 4, 2014 Category: Drugs & Pharmacology Authors: M. F. Dawwas, G. P. Aithal Tags: Original Article Source Type: research

Uricaemia and left ventricular mass in hypertensive patients
ConclusionsElevated uric acid levels are independently related to the left ventricular mass in hypertensive women without the metabolic syndrome. In these patients with a low cardiovascular risk profile, uric acid might contribute to the development of subclinical cardiac damage.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - September 4, 2014 Category: Journals (General) Authors: Cristiana Catena, GianLuca Colussi, Frine Capobianco, Gabriele Brosolo, Leonardo A. Sechi Tags: Original Paper Source Type: research

Impact of Metabolic Disturbances and Malnutrition‐Inflammation on 6‐Year Mortality in Japanese Patients Undergoing Hemodialysis
Abstract Metabolic syndrome confers an increased risk of cardiovascular disease (CVD) in the general population. The relationship between adiponectins, and clinical outcomes in patients undergoing hemodialysis remains controversial. We investigated whether adiponectins, biomarkers of inflammation, nutrition status and clinical features predict the mortality of patients undergoing hemodialysis for 6 years. We measured baseline plasma total and high‐molecular‐weight (HMW) adiponectins, tumor necrosis factor (TNF)‐α, serum high sensitivity C‐reactive protein (hsCRP), and clinical characteristics including visceral fa...
Source: Therapeutic Apheresis and Dialysis - September 4, 2014 Category: Hematology Authors: Naoki Nakagawa, Motoki Matsuki, Naoyuki Yao, Tomoya Hirayama, Hironori Ishida, Kenjiro Kikuchi, Naoyuki Hasebe Tags: Original Article Source Type: research

Telomere length as a marker of cellular ageing is associated with prevalence and progression of metabolic syndrome.
Conclusions Cellular aging, as assessed by TL, is associated with a higher metabolic risk profile which maintains to be unfavorable even after a period of six years. These findings suggest that cellular aging might play a role in the onset of various aging-related somatic diseases via its effect on metabolic alterations. PMID: 25188715 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 4, 2014 Category: Endocrinology Authors: Révész D, Milaneschi Y, Verhoeven JE, Penninx BW Tags: J Clin Endocrinol Metab Source Type: research

Relationships between body mass index, fat mass, muscle mass, and musculoskeletal pain in community residents
Conclusions. Increase in fat mass and fat/muscle mass ratio was significantly associated with musculoskeletal pain among females. Widespread pain was significantly associated with a high fat/muscle ratio after adjusting for confounders. Understanding the relation between fat mass and pain may provide insights into preventative measures and therapeutic strategies for musculoskeletal pain. © 2014 American College of Rheumatology. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - September 3, 2014 Category: Rheumatology Authors: Jong Jin Yoo, Seung Hun Lim, Nam Han Cho, Hyun Ah Kim Tags: Full Length Source Type: research

Adiponectin resistance and pro-inflammatory changes in the visceral adipose tissue induced by fructose consumption via ketohexokinase-dependent pathway.
This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin resistance induced by high fructose, a widespread component of Western diets. PMID: 25187370 [PubMed - as supplied by publisher] (Source: Diabetes)
Source: Diabetes - September 3, 2014 Category: Endocrinology Authors: Marek G, Pannu V, Shanmugham P, Pancione B, Mascia D, Crosson S, Ishimoto T, Sautin YY Tags: Diabetes Source Type: research

Dietary supplementation with tomato-juice in patients with metabolic syndrome: A suggestion to alleviate detrimental clinical factors.
Abstract Lycopene, a carotenoid, is known for its antioxidant properties. Little is known, though, about the relationship of dietary tomato-juice intake and risks factors, like inflammation, insulin resistance and hyperlipidemia, implicated in metabolic syndrome. In the present study, we examined whether supplementation with tomato-juice has any implication on the risk status of patients with metabolic syndrome. A comparative study was conducted in 27 individuals diagnosed with metabolic syndrome. Fifteen of them were instructed to use commercially available tomato-juice as refreshment 4 times a week over a period ...
Source: Food and Chemical Toxicology - September 3, 2014 Category: Food Science Authors: Tsitsimpikou C, Tsarouhas K, Kioukia-Fougia N, Skondra C, Fragkiadaki P, Papalexis P, Stamatopoulos P, Kaplanis I, Hayes AW, Tsatsakis A, Rentoukas E Tags: Food Chem Toxicol Source Type: research

Comorbidities and cardiovascular risk factors in patients with psoriasis
CONCLUSIONS: Patients had high prevalence of cardiovascular comorbidities, and high cardiovascular risk according to the Framingham risk score. Further epidemiological studies are needed in Brazil for validation of our results. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - September 2, 2014 Category: Dermatology Source Type: research

Prevalence of Metabolic Syndrome and its components in a Brazilian sample of pemphigus patients
CONCLUSION: The components of metabolic syndrome are more numerous in pemphigus when compared with Brazilian casuistic samples. Future studies are necessary to assure that metabolic syndrome may be associated with pemphigus per se, including a greater casuistic sample of patients who have not taken corticoids. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - September 2, 2014 Category: Dermatology Source Type: research