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This page shows you the latest research publications in this category.

Nut consumption is inversely associated with both cancer and total mortality in a Mediterranean population: prospective results from the Moli-sani study.
In conclusion, nut intake was associated with reduced cancer and total mortality. The protection was stronger in individuals with lower adherence to MD, whereas it was similar in high-risk groups (diabetics, obese, smokers or those with the metabolic syndrome), as compared with low-risk subjects. Inflammation did not explain the observed relationship. PMID: 26313936 [PubMed - in process] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - August 30, 2015 Category: Nutrition Authors: Bonaccio M, Di Castelnuovo A, De Curtis A, Costanzo S, Bracone F, Persichillo M, Donati MB, de Gaetano G, Iacoviello L Tags: Br J Nutr Source Type: research

Gender- and race-specific metabolic score and cardiovascular disease mortality in adults: A structural equation modeling approach-United States, 1988-2006.
CONCLUSIONS: When assessing CVD mortality risk, MetS score provided additional information than MetS (yes/no). PMID: 26308480 [PubMed - in process] (Source: Obesity)
Source: Obesity - August 29, 2015 Category: Eating Disorders and Weight Management Authors: Mercado CI, Yang Q, Ford ES, Gregg E, Valderrama AL Tags: Obesity (Silver Spring) Source Type: research

A systematic review of dietary advice with or without oral nutritional supplements in patients with changes in body composition and metabolic markers receiving highly active antiretroviral therapy (HAART).
HIV patients that receive highly active antiretroviral treatment can develop excessive muscle loss (wasting), lipoatrophy or lipohypertrophy, lipid abnormalities and insulin resistance (lipodystrophy)(1). Extreme weight loss predicts negative prognosis for patient’s survival while HIV lipodystrophy increases the risk of developing cardiovascular disease, metabolic syndrome, impairs quality of life and increases mortality (2). (Source: e-SPEN, The European e-Journal of Clinical Nutrition and Metabolism)
Source: e-SPEN, The European e-Journal of Clinical Nutrition and Metabolism - August 29, 2015 Category: Nutrition Authors: E. Spyreli Source Type: research

Association of arterial hypertension and cognitive impairment in euthymic bipolar disorder.
CONCLUSION: Despite relatively small sample size, noticeable association of hypertension and cognitive impairment was revealed. This might indicate possible way of enhancing cognition in bipolar disorder by treating elevated blood pressure. PMID: 26313398 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - August 29, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Lipid accumulation product and metabolic syndrome: a population-based study in northern Iran, Amol
Conclusion LAP has a strong and reliable diagnostic accuracy for MetS in Iranian population in the north of Iran. LAP showed a better predictability than other obesity indexes assessed in the present study. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 29, 2015 Category: Endocrinology Source Type: research

Bile acids: emerging role in management of liver diseases
Abstract Bile acids are well known for their effects on cholesterol homeostasis and lipid digestion. Since the discovery of bile acid receptors, of which there are farnesoid X receptor (FXR), a nuclear receptor, and the plasma membrane G-protein receptor, as well as Takeda G-protein coupled receptor clone 5, further roles have been elucidated for bile acids including glucose and lipid metabolism as well as inflammation. Additionally, treatment with bile acid receptor agonists has shown a decrease in the amount of atherosclerosis plaque formation and decreased portal vascular resistance and portal hypotension in an...
Source: Hepatology International - August 29, 2015 Category: Infectious Diseases Source Type: research

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3
Publication date: Available online 28 August 2015 Source:Cell Reports Author(s): Michele Cioffi, Mireia Vallespinos-Serrano, Sara M. Trabulo, Pablo Jose Fernandez-Marcos, Ashley N. Firment, Berta N. Vazquez, Catarina R. Vieira, Francesca Mulero, Juan A. Camara, Ultan P. Cronin, Manuel Perez, Joaquim Soriano, Beatriz G. Galvez, Alvaro Castells-Garcia, Verena Haage, Deepak Raj, Diego Megias, Stephan Hahn, Lourdes Serrano, Anne Moon, Alexandra Aicher, Christopher Heeschen Conquering obesity has become a major socioeconomic challenge. Here, we show that reduced expression of the miR-25-93-106b c...
Source: Cell Reports - August 29, 2015 Category: Cytology Source Type: research

[The prevalence of obesity and metabolic syndrome in paediatric patients with epilepsy treated in monotherapy with valproic acid].
CONCLUSIONS: Patients treated with VPA who become obese may go on to develop metabolic syndrome. They require careful monitoring and, if they are seen to put on weight, withdrawal of the drug should be considered. PMID: 26308840 [PubMed - as supplied by publisher] (Source: Revista de Neurologia)
Source: Revista de Neurologia - August 28, 2015 Category: Neurology Authors: Carmona-Vazquez CR, Ruiz-Garcia M, Pena-Landin DM, Diaz-Garcia L, Greenawalt SR Tags: Rev Neurol Source Type: research

Association between Serum Sialic Acid Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study
Conclusions: Our results showed a significant association between serum SA levels and NAFLD.Ann Nutr Metab 2015;67:69-75 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - August 28, 2015 Category: Nutrition Source Type: research

Electromyographic activity and insulin resistance
Micussi MT, Freitas RP, Angelo PH, Soares EM, Lemos TM, Maranhão TM (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - August 28, 2015 Category: Endocrinology Source Type: research

Fat and Sucrose Intake Induces Obesity‐Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats
ABSTRACT Metabolic and bone effects were investigated in growing (G, n = 45) and mature (M, n = 45) rats fed a high‐fat/high‐sucrose diet (HFS) isocaloric to the chow diet of controls (C, n = 30 per group). At week 19, a subset of 15 rats in each group (HFS or C, at both ages) was analyzed. Then one‐half of the remaining 30 HFS rats in each groups continued HFS and one‐half were shifted to C until week 27. Although no serum or bone marrow inflammation was seen, HFS increased visceral fat, serum leptin and insulin at week 19 and induced further alterations in lipid profile, serum adiponectin, and TGFβ1,...
Source: Journal of Bone and Mineral Research - August 28, 2015 Category: Orthopaedics Authors: Cédric Lavet, Aline Martin, Marie‐Thérèse Linossier, Arnaud Vanden Bossche, Norbert Laroche, Mireille Thomas, Maude Gerbaix, Patrick Ammann, Antoine Fraissenon, Marie‐Hélène Lafage‐Proust, Daniel Courteix, Laurence Vico Tags: Original Article Source Type: research

The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents [Patient-Oriented and Epidemiological Research]
In conclusion, this is the first evidence that n-3 LC-PUFAs may modulate the impact of the GCKR rs1260326 polymorphism on TG concentrations in adolescents. Several molecular mechanisms, in link with glucose uptake, could explain these findings. (Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - August 28, 2015 Category: Lipidology Authors: Rousseaux, J., Duhamel, A., Dumont, J., Dallongeville, J., Molnar, D., Widhalm, K., Manios, Y., Sjostrom, M., Kafatos, A., Breidenassel, C., Gonzales-Gross, M., Cuenca-Garcia, M., Censi, L., Ascension, M., De Henauw, S., Moreno, L. A., Meirhaeghe, A., Got Tags: Patient-Oriented and Epidemiological Research Source Type: research

Dietary cholesterol induces hepatic inflammation and blunts mitochondrial function in the liver of high fat fed mice
The present study investigated the role of dietary cholesterol and fat in the development of non-alcoholic fatty liver disease (NAFLD), a common liver disease in metabolic disorders. Mice were fed a diet of either regular chow (CH), chow supplemented with 0.2% w/w cholesterol (CHC), high fat (HF, 45 kcal%) or HF with cholesterol (HFC) for 17 weeks. While both HF and HFC groups displayed hepatic steatosis and metabolic syndrome, only HFC group developed the phenotype of liver injury, as indicated by an increase in plasma level of alanine transaminase (ALT, by 50~80%). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - August 28, 2015 Category: Biochemistry Authors: Songpei Li, Xiao-Yi Zeng, Xiu Zhou, Hao Wang, Eunjung Jo, Stephen R. Robinson, Aimin Xu, Ji-Ming Ye Source Type: research

Importance of anthropometry in assessing insulin resistance as a pre-alarming sign before the onset of metabolic syndrome: a study among apparently healthy subjects
Abstract Insulin resistance (IR) and obesity are inter-related causes of metabolic syndrome. Early identification before the onset of metabolic syndrome will be useful to lead a healthy life. The purpose of the present study was to identify the importance of IR before the onset of metabolic syndrome in apparently healthy, non-diabetics subjects. Data of 227 apparently healthy non-diabetics (20-70 years) who reside in a suburban area in Colombo district, Sri Lanka, were recruited for this study. Fasting blood glucose (FBG), fasting serum insulin (FSI), weight, height, waist circumference (WC), hip circumference (H...
Source: International Journal of Diabetes in Developing Countries - August 27, 2015 Category: Endocrinology Source Type: research

Increased expression of the interleukin-1 receptor-associated kinase (IRAK)-1 is associated with adipose tissue inflammatory state in obesity
Conclusions: The elevated IRAK-1 expression in obese adipose tissue showed consensus with local/circulatory inflammatory signatures and represented as a tissue marker for metabolic inflammation. The data have clinical significance as interventions causing IRAK-1 suppression may alleviate meta-inflammation in obesity/T2D. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - August 27, 2015 Category: Endocrinology Authors: Rasheed AhmadPuthiyaveetil ShihabReeby ThomasMunera AlghanimAmal HasanSardar SindhuKazem Behbehani Source Type: research

High prevalence of cardiovascular co-morbidities in patients with symptomatic knee or hand osteoarthritis.
CONCLUSIONS: A high frequency of MetS and CVEs was observed in OA patients in a primary care setting. PMID: 26312543 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - August 27, 2015 Category: Rheumatology Authors: Calvet J, Orellana C, Larrosa M, Navarro N, Chillarón JJ, Pedro-Botet J, Galisteo C, García-Manrique M, Gratacós J Tags: Scand J Rheumatol Source Type: research

Medical comorbidity and medical complications associated with binge‐eating disorder
DiscussionAdditional prospective studies are needed. Although the results of the available studies are not definitive and provide somewhat mixed results, there does appear to be a clear suggestion of an increased risk for the development of components of the metabolic syndrome in adults and children. © 2015 Wiley Periodicals, Inc. (Int J Eat Disord 2015). (Source: International Journal of Eating Disorders)
Source: International Journal of Eating Disorders - August 27, 2015 Category: Eating Disorders and Weight Management Authors: James E. Mitchell Tags: Original Article Source Type: research

Identification and treatment of patients with homozygous familial hypercholesterolaemia: information and recommendations from a Middle East advisory panel.
We present clinical practice guidelines for the diagnosis and treatment of homozygous familial hypercholesterolemia (HoFH) in the Middle East region. While guidelines are broadly applicable in Europe, in the Middle East we experience a range of confounding factors that complicate disease management to a point whereby the European guidance cannot be applied without significant modification. Specifically, for disease prevalence, the Middle East region has an established epidemic of diabetes and metabolic syndrome that can complicate treatment and mask a clinical diagnosis of HoFH. We also have a high incidence of consanguine...
Source: Current Vascular Pharmacology - August 27, 2015 Category: Drugs & Pharmacology Authors: Al-Ashwal A, Alnouri F, Sabbour H, Al-Mahfouz A, Al-Sayed N, Razzaghy-Azar M, Al-Allaf F, Al-Waili K, Banerjee Y, Genest J, Santos RD, Al-Rasadi K Tags: Curr Vasc Pharmacol Source Type: research

Obstructive sleep apnea syndrome in non severely obese patients with nonalcoholic fatty liver disease
Background. A high prevalence of obstructive sleep apnea syndrome (OSAS) has been reported in severely obese patients with nonalcoholic fatty liver disease (NAFLD), associated with obesity and metabolic syndrome. Aim of the study is to assess the prevalence of OSAS in patients with NAFLD without severe obesity. Methods. Thirty-five patients with histological NAFLD and body mass index (BMI) (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - August 26, 2015 Category: Neuroscience Authors: A. Lo Monaco, E. Tobaldini, M. Bulgheroni, M. Pecis, M. Stracuzzi, E. Pulixi, S. Pelusi, M. Porzio, L. Fracanzani, S. Fargion, L. Valenti, N. Montano Tags: P13.3 Source Type: research

Elevated sympathetic tone as an etiological factor of cardiometabolic disease
The sympathetic nervous system (SNS) plays a key role in both cardiovascular and metabolic regulation hence disturbances in SNS regulation are likely to impact on both cardiovascular and metabolic health. With excess adiposity, in particular when visceral fat accumulation is present, sympathetic activation commonly occurs. The cause and extent of sympathetic activation in obesity may be attributed to factors such as the release of adipokines from the adipose tissue, the existence of sleep apnoea, components of the metabolic syndrome, distribution and type of fat and underlying stress. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - August 26, 2015 Category: Neuroscience Authors: E.A. Lambert Tags: 8.2 Source Type: research

Insulin resistance: A new consequence of altered carotid body chemoreflex?
The carotid bodies (CBs) are arterial chemoreceptors that respond to hypoxia by increasing action potential frequency in their sensory nerve, the carotid sinus nerve (CSN), increasing minute ventilation and activating the sympathetic nervous system. Besides its role in the control of ventilation, the CB has been proposed as a metabolic sensor implicated in the control of energy homeostasis. We have recently described that CB overactivation is the pathophysiological mechanism involved in the etiology of insulin resistance and hypertension, core central metabolic and hemodynamic disturbances of highly prevalent diseases like...
Source: Autonomic Neuroscience: Basic and Clinical - August 26, 2015 Category: Neuroscience Authors: S.V. Conde, J.F. Sacramento, M.J. Ribeiro, B.F. Melo, M.P. Guarino Tags: 10.2 Source Type: research

Brain mitochondrial biogenesis and bioenergetics in autonomic regulation of blood pressure: Significance in metabolic syndrome
Excess production of the reactive oxygen species, in particular superoxide, from mitochondria has been demonstrated to be the initial cellular response leading to cardiovascular complications associated with metabolic syndrome; however, the underlying mechanisms are not fully understood. In the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons reside, dysfunction of mitochondrial bioenergetic, including suppression of protein expression and enzyme activity of the electron transport enzyme complexes I, II and IV, decrease in ATP generation and increase in mitochondrial superoxide production, were obse...
Source: Autonomic Neuroscience: Basic and Clinical - August 26, 2015 Category: Neuroscience Authors: Kay L.H. Wu, Samuel H.H. Chan, Julie Y.H. Chan Tags: 28.4 Source Type: research

rs2059806 polymorphism and the risk of preeclampsia
Introduction: Preeclampsia is a pregnancy specific disease that occurs in 2–8% of pregnancies and is a leading cause of maternal morbidity and mortality. Increasing evidence suggests that the effects of preeclampsia on a woman’s health are not restricted to the pregnancy but that preeclampsia could represent a risk factor for later life vascular and metabolic diseases. The INSR rs2059806 single nucleotide polymorphism (SNP) is a risk factor for essential hypertension, type 2 diabetes and metabolic syndrome. (Source: Placenta)
Source: Placenta - August 26, 2015 Category: Reproduction Medicine Authors: Prabha Andraweera, Gustaaf Dekker, Kathy Gatford, Shalem Leemaqz, Lesley McCowan, Roahn Jayasekara, Vajira Dissanayake, Claire Roberts Source Type: research

Adherence to Group Exercise and Diet Therapy Significantly Lowers Metabolic Syndrome Risks in Low-Income Inner-City HIV+ Adults
The participant will be able to identify four components that increase adherence to group exercise and diet therapy among inner-city HIV+ adults to improve four metabolic syndrome risk factors. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - August 26, 2015 Category: Nutrition Authors: J. Rodrigues, L. Girault, P. Guthrie, X. Perez, A. Robinson, M. Serlin, S. Mannheimer Tags: Sunday, October 4 Source Type: research

Intake of Dietary Simple Sugars Contributes to Metabolic Syndrome in Division I College Football Players
Participants will be able to identify specific nutrients in the diets of football players that contribute to cardiometabolic disease risk. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - August 26, 2015 Category: Nutrition Authors: L. Mason, E. Powers, A. Hudson, L. Seabolt, K. Niswender, H. Silver Tags: Monday, October 5 Source Type: research

Anti oxidant potential of Metformin and Pioglitazone in Type 2 Diabetes Mellitus: Beyond their anti glycemic effect
Conclusion Pioglitazone was superior to Metformin to improve oxidative stress as reflected by reduction in MDA but the antioxidant effect i.e. increases in SOD was seen with metformin only. The differing mechanism of actions of the two drugs on oxidative stress favors co prescription of these drugs for better outcome in improving insulin resistance and diabetic complications. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - August 26, 2015 Category: Endocrinology Source Type: research

Twelve-week randomized study to compare the effect of vildagliptin vs. glibenclamide both added-on to metformin on endothelium function in patients with type 2 diabetes and hypertension
This study aims to evaluate the effect of vildagliptin on endothelial function and arterial stiffness in patients with T2DM and hypertension. Methods: Fifty over 35-year-old patients with T2DM and hypertension, without cardiovascular disease, will be randomly allocated to two groups: group 1 will receive vildagliptin added-on to metformin and group 2, glibenclamide added-on to metformin. Biochemical tests (glycemia, glycated hemoglobin, total cholesterol, high-density lipoprotein cholesterol, triglycerides, creatinine, alanine aminotransferase, ultrasensitive C-reactive protein, and microalbuminuria), 24-h non-invasive amb...
Source: Diabetology and Metabolic Syndrome - August 26, 2015 Category: Endocrinology Authors: Luciana Cosenso-MartinLuiz Giollo-JúniorDébora MartineliCláudia CesarinoMarcelo NakazoneJosé CipulloJosé Vilela-Martin Source Type: research

Vitamin D status and insulin sensitivity are novel predictors of resting metabolic rate: a cross-sectional analysis in Australian adults
Conclusion Vitamin D status and IS are novel independent predictors of RMR in adults. Future studies could validate a causal role for these factors in human energy metabolism. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - August 26, 2015 Category: Nutrition Source Type: research

Assessment of semen quality in patients with androgenetic alopecia in an infertility clinic
Conclusion This study showed that young adult men with moderate to severe AGA have poor quality of semen compared with those who have normal to mild AGA. (Source: Dermatologica Sinica)
Source: Dermatologica Sinica - August 26, 2015 Category: Dermatology Source Type: research

Serum Uric Acid Levels and Risk of Metabolic Syndrome: A Dose-Response Meta-analysis of Prospective Studies.
CONCLUSIONS: This meta-analysis suggests that higher SUA levels led to an increased risk of MS regardless of the study characteristics, and were consistent with a linear dose-response relationship. In addition, SUA was also a causal factor for the NAFLD risk. PMID: 26308292 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 26, 2015 Category: Endocrinology Authors: Yuan H, Yu C, Li X, Sun L, Zhu X, Zhao C, Zhang Z, Yang Z Tags: J Clin Endocrinol Metab Source Type: research

Kinin receptors as targets for obesity
Morais RL, Silva ED, Sales VM, Filippelli-Silva R, Mori MA, Bader M, Pesquero JB (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - August 25, 2015 Category: Endocrinology Source Type: research

Adipocyte iron regulates leptin and food intake
Dietary iron supplementation is associated with increased appetite. Here, we investigated the effect of iron on the hormone leptin, which regulates food intake and energy homeostasis. Serum ferritin was negatively associated with serum leptin in a cohort of patients with metabolic syndrome. Moreover, the same inverse correlation was observed in mice fed a high-iron diet. Adipocyte-specific loss of the iron exporter ferroportin resulted in iron loading and decreased leptin, while decreased levels of hepcidin in a murine hereditary hemochromatosis (HH) model increased adipocyte ferroportin expression, decreased adipocyte iro...
Source: Journal of Clinical Investigation - August 25, 2015 Category: Biomedical Science Authors: Yan Gao, Zhonggang Li, J. Scott Gabrielsen, Judith A. Simcox, Soh-hyun Lee, Deborah Jones, Bob Cooksey, Gregory Stoddard, William T. Cefalu, Donald A. McClain Source Type: research

Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia.
CONCLUSIONS: Our strongest findings in the GWA study and pathway analysis point towards an involvement of glucose metabolism in left STG thickness reduction in patients with schizophrenia only. These results are in line with recently published studies, which showed an increased prevalence of psychosis among patients with metabolic syndrome-related illnesses including diabetes. PMID: 26305511 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - August 25, 2015 Category: Psychiatry Authors: Wolthusen RP, Hass J, Walton E, Turner JA, Rössner V, Sponheim SR, Ho BC, Holt DJ, Gollub RL, Calhoun V, Ehrlich S Tags: World J Biol Psychiatry Source Type: research

The CardioMetabolic Health Alliance Working Toward a New Care Model for the Metabolic Syndrome
The Cardiometabolic Think Tank was convened on June 20, 2014, in Washington, DC, as a “call to action” activity focused on defining new patient care models and approaches to address contemporary issues of cardiometabolic risk and disease. Individual experts representing >20 professional organizations participated in this roundtable discussion. The Think Tank consensus was that the metabolic syndrome (MetS) is a complex pathophysiological state comprised of a cluster of clinically measured and typically unmeasured risk factors, is progressive in its course, and is associated with serious and extensive comorbidity, but t...
Source: Journal of the American College of Cardiology - August 24, 2015 Category: Cardiology Source Type: research

Six-year longitudinal course and outcomes of subtypes of depression.
ConclusionsCourse trajectories of depressive subtypes mostly ran parallel to each other, with baseline severity being the most important differentiator in course between groups. PMID: 26294366 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - August 24, 2015 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Effect of a high intake of cheese on cholesterol and metabolic syndrome: results of a randomized trial.
CONCLUSIONS: In conclusion, cholesterol levels did not increase after high intake of 27% fat Gouda-type cheese over 8 weeks' intervention, and stratified analysis showed that participants with metabolic syndrome had reduced cholesterol at the end of the trial. PMID: 26294049 [PubMed] (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - August 24, 2015 Category: Nutrition Authors: Nilsen R, Høstmark AT, Haug A, Skeie S Tags: Food Nutr Res Source Type: research

Insulin resistance and sarcopenia are closely related to metabolic syndrome in male and female adolescents.
PMID: 26299679 [PubMed - as supplied by publisher] (Source: Public Health Nutrition)
Source: Public Health Nutrition - August 24, 2015 Category: Global & Universal Authors: Kawada T Tags: Public Health Nutr Source Type: research

Molecular insight and pharmacological approaches targeting mitochondrial dynamics in skeletal muscle during obesity
Obesity‐associated insulin resistance is the major characteristic of the early stage of metabolic syndrome. A decline in mitochondrial function plays a role in the development of insulin resistance in obesity and type 2 diabetes. Accumulating data reveal that mitochondrial dynamics, the balance between mitochondrial fusion and fission, are an important factor in the maintenance of mitochondrial function. Thus, the mechanisms underlying the regulation of mitochondrial dynamics in obesity deserve further investigation. This review describes an overview of mitochondrial fusion and fission machineries, and discusses the mech...
Source: Annals of the New York Academy of Sciences - August 24, 2015 Category: Science Authors: Huei‐Fen Jheng, Shin‐Han Huang, Hsueh‐Maio Kuo, Michael W. Hughes, Yau‐Sheng Tsai Tags: Original Article Source Type: research

Scleredema. A multicentre study of characteristics, comorbidities, course and therapy in 44 patients
ConclusionsScleredema is a chronic debilitating disease associated with diabetes and metabolic syndrome, unresponsive to various treatments but not necessarily a life‐threatening condition. Although there is no definitive treatment, phototherapy should be attempted first. Treatment of primary disease including strict glycaemic control combined with physical therapy should be also employed. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - August 24, 2015 Category: Dermatology Authors: F. Rongioletti, F. Kaiser, E. Cinotti, D. Metze, M. Battistella, P.G. Calzavara‐Pinton, K. Damevska, G. Girolomoni, J. André, J.‐L. Perrot, W. Kempf, B. Cavelier‐Balloy Tags: Original Article Source Type: research

Effects of chronic dietary exposure to monosodium glutamate on feeding behavior, adiposity, gastrointestinal motility, and cardiovascular function in healthy adult rats
Conclusions & InferencesChronic treatment with MSG in the adult rat increased water intake. This supports its potential to improve acceptance of low‐fat regimens and to increase hydration in the elderly and sportspeople, often at risk of dehydration. Changes in colonic contractility and cardiovascular function could have some long‐term repercussions warranting further research. Regular intake of monosodium glutamate (MSG) in drinking water in adult rats enhanced drinking, but did not alter body weight gain or abdominal fat distribution, suggesting that this food additive is not necessarily involved in the developm...
Source: Neurogastroenterology and Motility - August 24, 2015 Category: Gastroenterology Authors: V. López‐Miranda, M. L. Soto‐Montenegro, J. A. Uranga‐Ocio, G. Vera, E. Herradón, C. González, C. Blas, M. Martínez‐Villaluenga, A. E. López‐Pérez, M. Desco, R. Abalo Tags: Original Article Source Type: research

Chrono-Immunology: Progress and Challenges in Understanding Links between the Circadian and Immune Systems.
This article is protected by copyright. All rights reserved. PMID: 26301993 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 24, 2015 Category: Allergy & Immunology Authors: Geiger SS, Fagundes CT, Siegel RM Tags: Immunology Source Type: research

High Prevalence of Cardiovascular Disease in End-Stage Kidney Disease Patients Ongoing Hemodialysis in Peru: Why Should We Care About It?
Conclusions. Cardiovascular disease prevalence is high in patients receiving hemodialysis in the main center in Lima. Diastolic dysfunction, age, specific hemoglobin levels, and effective blood flow may play an important role. PMID: 26294974 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - August 23, 2015 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Adipose Tissue and Metabolic Syndrome: Too Much, Too Little, or Neither
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - August 23, 2015 Category: Journals (General) Authors: Scott M. Grundy Tags: Review Source Type: research

Excessive daytime sleepiness among patients with metabolic syndrome
Conclusions Other explanations of EDS in subjects with metabolic syndrome can be related to obesity, depression, or diabetes rather than to sleep apnea. Subjects with metabolic syndrome should be screened for EDS regardless of sleep apnea. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - August 23, 2015 Category: Respiratory Medicine Source Type: research

Association of physical activity with metabolic syndrome in a predominantly rural Nigerian population
Conclusion The high prevalence of physical inactivity in this study population is a clear indication that concerted efforts to improve physical activity may be required. However, it seems that metabolic syndrome is not improved by being physically active. This suggests that interventions directed at physical activity alone may not produce optimal efficacy in this study population. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - August 23, 2015 Category: Endocrinology Source Type: research

The metabolic syndrome and accurate cardiovascular risk prediction in persons with type 2 diabetes mellitus
Conclusion The absolute cardiovascular risk score was similar in type 2 DM patients with or without the metabolic syndrome. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - August 23, 2015 Category: Endocrinology Source Type: research

Relation of serum uric acid to cardiovascular disease
The association between serum uric acid (SUA) and cardiovascular (CV) disease has long been recognized. However, it has not been definitively established whether SUA is merely a marker for risk or a causative agent in CV disease, or whether treatment targeting SUA levels affect outcomes. SUA is closely related to conditions such as hypertension, dyslipidemia, obesity, impaired glucose metabolism, and metabolic syndrome, which contribute to CV disease pathophysiology [1,2]. Although many studies have found SUA to be independently associated with CV risk and events [3,4], there have also been compelling arguments made that t...
Source: International Journal of Cardiology - August 23, 2015 Category: Cardiology Authors: Audrey H. Wu, James D. Gladden, Mustafa Ahmed, Ali Ahmed, Gerasimos Filippatos Source Type: research

The Duration of Breastfeeding and Its Association with Metabolic Syndrome among Obese Children.
Conclusion. In this study, breastfeeding was not associated with a reduced risk for metabolic syndrome, compared with formula feeding, in children who are obese. PMID: 26295060 [PubMed - in process] (Source: The Scientific World Journal)
Source: The Scientific World Journal - August 22, 2015 Category: Science Tags: ScientificWorldJournal Source Type: research

Predicting Metabolic Syndrome Using the Random Forest Method.
Conclusion. RF was shown to predict MS in an adult Thai population with an accuracy >98% and triglyceride levels were identified as the most informative variable associated with MS. Therefore, using RF to predict MS may be potentially beneficial in identifying MS status for preventing the development of diabetes mellitus and cardiovascular diseases. PMID: 26290899 [PubMed - in process] (Source: The Scientific World Journal)
Source: The Scientific World Journal - August 22, 2015 Category: Science Tags: ScientificWorldJournal Source Type: research

Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study
This study aims to investigate the association between body mass index (BMI) trajectories during infancy/childhood and later metabolic risk in order to identify sensitive periods of growth affecting health. In a first step, BMI trajectories of 3301 European children that participated in the multi-centre Identification and Prevention of Dietary and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) study were modelled using linear-spline mixed-effects models. The estimated random coefficients indicating initial subject-specific BMI and rates of change in BMI over time were used as exposure variables in a sec...
Source: European Journal of Epidemiology - August 22, 2015 Category: Epidemiology Source Type: research