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This page shows you the latest research publications in this category.

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro
Conclusions The consumption of sesame and flaxseed may be beneficial to decrease metabolic parameters that are generally altered in MetS. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - November 26, 2014 Category: Nutrition Source Type: research

Chronic kidney disease and nonalcoholic Fatty liver disease-is there a link?
Authors: Orlić L, Mikolasevic I, Bagic Z, Racki S, Stimac D, Milic S Abstract Research in recent years has led to the recognition of the importance of nonalcoholic fatty liver disease (NAFLD) and its relationship to the metabolic syndrome (MS). This has led to a growing interest in the potential prognostic value of NAFLD for adverse cardiovascular disease (CVD) outcome. On the other hand, searching for new risk factors for chronic kidney disease (CKD) development and progression is very important. Growing evidence suggests that the MS is an important factor in the pathogenesis of CKD. The best confirmation of this...
Source: Gastroenterology Research and Practice - November 26, 2014 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Prevalence and associated metabolic factors of gallstone disease in the elderly agricultural and fishing population of taiwan.
Conclusion. In the study population, female sex, older age, and MetS were associated with higher GSD prevalence. The population exhibited other sex-related differences. PMID: 24707283 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - November 26, 2014 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

L-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled study
Conclusion: Intravenous L-carnitine can ameliorate fasting-induced hunger, fatigue, cholesterol abnormalities and hepatic metabolic changes and facilitate fasting-induced weight loss in MetS patients.Trial registration: ChiCTR-TNRC-12002835. (Source: BioMed Central)
Source: BioMed Central - November 26, 2014 Category: Journals (General) Authors: Jun-jie ZhangZhi-bing WuYou-jin CaiBin KeYing-juan HuangChao-ping QiuYu-bing YangLan-ying ShiJian Qin Source Type: research

Psoriasis Is a Systemic Disease with Multiple Cardiovascular and Metabolic Comorbidities
This article summarizes the current literature on cardiovascular and metabolic comorbidities in psoriasis, identifies research gaps, and suggests management strategies to reduce cardiovascular risk in patients with moderate to severe psoriasis. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - November 25, 2014 Category: Dermatology Authors: Caitriona Ryan, Brian Kirby Source Type: research

Immune cell crosstalk in obesity: a key role for costimulation?
Abstract In the past two decades, numerous experimental and clinical studies have established the importance of inflammation and immunity in the development of obesity and its metabolic complications, including insulin resistance and type 2 diabetes mellitus. In this context, T cells orchestrate inflammatory processes in metabolic organs, such as the adipose tissue (AT) and liver, thereby mediating obesity-related metabolic deterioration. Costimulatory molecules, which are present on antigen-presenting cells and naïve T cells in the AT, are known to mediate the crosstalk between the adaptive and innate immune syst...
Source: Diabetes - November 25, 2014 Category: Endocrinology Authors: Seijkens T, Kusters P, Chatzigeorgiou A, Chavakis T, Lutgens E Tags: Diabetes Source Type: research

PPARG in Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative Isoforms.
Authors: Aprile M, Ambrosio MR, D'Esposito V, Beguinot F, Formisano P, Costa V, Ciccodicola A Abstract The nuclear receptor PPAR γ is a key regulator of adipogenesis, and alterations of its function are associated with different pathological processes related to metabolic syndrome. We recently identified two PPARG transcripts encoding dominant negative PPAR γ isoforms. The existence of different PPARG variants suggests that alternative splicing is crucial to modulate PPAR γ function, underlying some underestimated aspects of its regulation. Here we investigate PPARG expression in different tissues and cells affe...
Source: PPAR Research - November 25, 2014 Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research

PPARs and Metabolic Syndrome.
Authors: Chen L, Jia Z, Yang G PMID: 24782893 [PubMed] (Source: PPAR Research)
Source: PPAR Research - November 25, 2014 Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research

PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance.
Authors: Todorov VT Abstract During the last years accumulating evidence demonstrated that the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) regulates the expression of renin gene and thus the overall renin production. This review summarizes the current knowledge of the transcriptional control of the renin gene by PPARgamma received from variety of models ranging from cell culture to transgenic animals. The molecular mechanisms of the PPARgamma action on renin are particularly interesting because they are featured by two newly described characteristics: one of them is the recently id...
Source: PPAR Research - November 25, 2014 Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research

Effects of Pioglitazone on Asymmetric Dimethylarginine and Components of the Metabolic Syndrome in Nondiabetic Patients (EPICAMP Study): A Double-Blind, Randomized Clinical Trial.
Authors: Shokouh P, Joharimoghadam A, Roohafza H, Sadeghi M, Golabchi A, Boshtam M, Sarrafzadegan N Abstract The present trial aimed to investigate the effects of pioglitazone on the serum level of asymmetric dimethylarginine (ADMA), a marker of endothelial function, and some indices of inflammation and glucose and lipid metabolism in nondiabetic metabolic syndrome patients. 104 eligible participants (57% female; age between 20 and 70) were enrolled in a double-blind placebo-controlled trial and were randomized to receive either pioglitazone (uptitrated to 30 mg/day) or matching placebo for 24 weeks. Participan...
Source: PPAR Research - November 25, 2014 Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research

Interaction Effects of the Leu162Val PPAR α and Pro12Ala PPAR γ 2 Gene Variants with Renal Function in Metabolic Syndrome Population.
Authors: Mohamed Youssef S, Mohamed N, Afef S, Khaldoun BH, Fadoua N, Fadhel NM, Naceur SM Abstract Leu162Val PPAR α and Pro12Ala PPAR γ 2 were investigated for their individual and their interactive impact on MS and renal functionality (RF). 522 subjects were investigated for biochemical and anthropometric measurements. The diagnosis of MS was based on the IDF definition (2009). The HOMA 2 was used to determine HOMA- β , HOMA-S and HOMA-IR from FPG and FPI concentrations. RF was assessed by estimating the GFR. PCR-RFLP was performed for DNA genotyping. Allele frequencies were 0.845 for Pro and 0.155 for Ala, an...
Source: PPAR Research - November 25, 2014 Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research

Peroxisome proliferator-activated receptor genetic polymorphisms and nonalcoholic Fatty liver disease: any role in disease susceptibility?
Authors: Dongiovanni P, Valenti L Abstract Nonalcoholic fatty liver disease (NAFLD) defines a wide spectrum of liver diseases that extend from simple steatosis, that is, increased hepatic lipid content, to nonalcoholic steatohepatitis (NASH), a condition that may progress to cirrhosis with its associated complications. Nuclear hormone receptors act as intracellular lipid sensors that coordinate genetic networks regulating lipid metabolism and energy utilization. This family of transcription factors, in particular peroxisome proliferator-activated receptors (PPARs), represents attractive drug targets for the managem...
Source: PPAR Research - November 25, 2014 Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research

Modulation of PPAR-γ by Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases.
Authors: Ortuño Sahagún D, Márquez-Aguirre AL, Quintero-Fabián S, López-Roa RI, Rojas-Mayorquín AE Abstract A direct correlation between adequate nutrition and health is a universally accepted truth. The Western lifestyle, with a high intake of simple sugars, saturated fat, and physical inactivity, promotes pathologic conditions. The main adverse consequences range from cardiovascular disease, type 2 diabetes, and metabolic syndrome to several cancers. Dietary components influence tissue homeostasis in multiple ways and many different functional foods have been associated with various health benefits when con...
Source: PPAR Research - November 25, 2014 Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research

The metabotrophic NGF and BDNF: an emerging concept.
Authors: Chaldakov G Abstract The field of neurotrophins, particularly, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), has witnessed a number of breakthroughs in recent years. There is evidence now that NGF and BDNF mediate multiple biological phenomena, ranging from the Rita Levi Montalcini's neurotrophic through immunotrophic to epitheliotrophic and nociceptive effects. In 2003 we, for the first time, enriched the "NGFome" with one more expression presented in our concept of NGF metabotrophicity, also that of BDNF. This envisages that these two factors may operate as metabotrophins, that ...
Source: Archives Italiennes de Biologie - November 25, 2014 Category: Neuroscience Tags: Arch Ital Biol Source Type: research

Brown adipose tissue: clinical impact of a re-discovered thermogenic organ.
Authors: Vijgen G, van Marken Lichtenbelt W Abstract Brown adipose tissue (BAT) is physiologically present and active in adult humans. The stimulation of BAT in man can potentially increase total daily energy expenditure and is seen as a possible target to treat obesity. Altered BAT activity is also related to other diseases and therefore the therapeutic potential of BAT could reach beyond obesity. This is supported by both in vitro and in vivo reports from animal studies, describing the possible role of BAT in both physiology and pathophysiology. In addition, since the discovery of functional BAT several clinicall...
Source: Frontiers in Bioscience - Elite - November 25, 2014 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Association of insulin resistance with overactive bladder in female patients.
CONCLUSIONS: Insulin resistance can be associated to overactive bladder and may play significant role in pathogenesis. PMID: 23346484 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - November 25, 2014 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Duration of type 2 diabetes and very low density lipoprotein levels are associated with cognitive dysfunction in metabolic syndrome.
Authors: Yogi-Morren D, Galioto R, Strandjord SE, Kennedy L, Manroa P, Kirwan JP, Kashyap S, Gunstad J Abstract Type 2 diabetes (T2D) is now recognized as an independent risk factor for accelerated cognitive decline and neurological conditions like Alzheimer's disease. Less is known about the neurocognitive function of T2D patients with comorbid metabolic syndrome, despite their elevated risk for impairment. Computerized testing in 47 adults with T2D that met criteria for NCEP metabolic syndrome revealed that cognitive impairment was prevalent, including 13% in tests of memory, 50% in attention, and 35% in executiv...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Sex Differences in Associations of Depressive Symptoms with Cardiovascular Risk Factors and Metabolic Syndrome among African Americans.
Authors: Cooper DC, Trivedi RB, Nelson KM, Reiber GE, Zonderman AB, Evans MK, Waldstein SR Abstract Young to middle-aged women usually have notably lower rates of cardiovascular disease (CVD) than their male counterparts, but African American women lack this advantage. Their elevated CVD may be influenced by sex differences in associations between depressed mood and CVD risk factors. This cross-sectional study examined whether relations between scores on the Center for Epidemiologic Studies-Depression (CES-D) scale and a spectrum of CVD risk factors varied by sex among African Americans (n = 1076; ages 30-64) from ...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Are cardiovascular risk factors associated with verbal learning and memory impairment in patients with schizophrenia? A cross-sectional study.
Conclusion. Our findings suggest that MetS and alcohol use may be linked with memory impairment in schizophrenia. These findings provide important insights into the interdependencies of cardiovascular risk factors and cognitive disorders and support novel strategies for treating and preventing cognitive disorders in patients with schizophrenia. PMID: 23227310 [PubMed] (Source: Cardiovascular Psychiatry and Neurology)
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Increased Serum PAI-1 Levels in Subjects with Metabolic Syndrome and Long-Term Adverse Mental Symptoms: A Population-Based Study.
In conclusion, our results suggest that in men high PAI-1 levels are independently associated with long-term mental symptomatology. PMID: 20300596 [PubMed] (Source: Cardiovascular Psychiatry and Neurology)
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Alzheimer's disease promotion by obesity: induced mechanisms-molecular links and perspectives.
Authors: Businaro R, Ippoliti F, Ricci S, Canitano N, Fuso A Abstract The incidence of AD is increasing in parallel with the increase in life expectancy. At the same time the prevalence of metabolic syndrome and obesity is reaching epidemic proportions in western populations. Stress is one of the major inducers of visceral fat and obesity development, underlying accelerated aging processes. Adipose tissue is at present considered as an active endocrine organ, producing important mediators involved in metabolism regulation as well as in inflammatory mechanisms. Insulin and leptin resistance has been related to the d...
Source: Current Gerontology and Geriatrics Research - November 25, 2014 Category: Geriatrics Tags: Curr Gerontol Geriatr Res Source Type: research

Epigenetic regulation on gene expression induced by physical exercise.
Authors: Ntanasis-Stathopoulos J, Tzanninis JG, Philippou A, Koutsilieris M Abstract It is well established that physical exercise modulates the function of many physiological systems, such as the musculoskeletal, the cardiovascular and the nervous system, by inducing various adaptations to the increased mechanical load and/or metabolic stress of exercise. Many of these changes occur through epigenetic alterations to DNA, such as histone modifications, DNA methylations, expression of microRNAs and changes of the chromatin structure. All these epigenetic alterations may have clinical relevance, thus playing an impor...
Source: Journal of Musculoskeletal Neuronal Interactions - November 25, 2014 Category: Neurology Tags: J Musculoskelet Neuronal Interact Source Type: research

Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease.
Authors: Guarner V, Rubio-Ruiz ME Abstract Aging is associated with immunosenescence and accompanied by a chronic inflammatory state which contributes to metabolic syndrome, diabetes and their cardiovascular consequences. Risk factors for cardiovascular diseases (CVDs) and diabetes overlap, leading to the hypothesis that both share an inflammatory basis. Obesity is increased in the elderly population, and adipose tissue induces a state of systemic inflammation partially induced by adipokines. The liver plays a pivotal role in the metabolism of nutrients and exhibits alterations in the expression of genes associated...
Source: Interdisciplinary Topics in Gerontology - November 25, 2014 Category: Geriatrics Tags: Interdiscip Top Gerontol Source Type: research

Metabolic syndrome and cancer: from bedside to bench and back.
Authors: Extermann M Abstract As older patients present with an average of three comorbidities beside their cancer, geriatric oncology can provide unique clues to translational research in aging and cancer. We illustrate this approach with the example of the metabolic syndrome and cancer. Epidemiologic and clinical cohorts highlighted an association between the metabolic syndrome and a higher risk and worse prognosis of various cancers. In a bedside-to-bench transition, this led to an interest in analyzing the potential mechanisms underlying this association. At least ten potential mechanisms could be implicated, w...
Source: Interdisciplinary Topics in Gerontology - November 25, 2014 Category: Geriatrics Tags: Interdiscip Top Gerontol Source Type: research

Testosterone deficiency syndrome: cellular and molecular mechanism of action.
Authors: Carruthers M Abstract There is virtually no correlation between what are generally accepted to be the symptoms of deficient androgen in men and levels of androgens as measured in the laboratory. Now that androgen deficiency is being shown to play a part in conditions as diverse as metabolic syndrome, diabetes, and coronary heart disease, a hypothesis is needed to explain this apparent discrepancy between measured androgen levels and our understanding of the symptoms of androgen deficiency. When the possible mechanisms for androgen actions are considered, one explanation emerges that androgen may act much l...
Source: Current Aging Science - November 25, 2014 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Light-at-night-induced circadian disruption, cancer and aging.
Authors: Anisimov VN, Vinogradova IA, Panchenko AV, Popovich IG, Zabezhinski MA Abstract Light-at-night has become an increasing and essential part of the modern lifestyle and leads to a number of health problems, including excessive body mass index, cardiovascular diseases, diabetes, and cancer. The International Agency for Research on Cancer (IARC) Working Group concluded that "shift-work that involves circadian disruption is probably carcinogenic to humans" (Group 2A) [1]. According to the circadian disruption hypothesis, light-at-night might disrupt the endogenous circadian rhythm and specifically suppress noct...
Source: Current Aging Science - November 25, 2014 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Pathogenesis of hepatocellular carcinoma according to aetiology
Publication date: October 2014 Source:Best Practice & Research Clinical Gastroenterology, Volume 28, Issue 5 Author(s): Jean-Charles Nault Hepatocellular carcinoma is related to various etiologies including hepatitis B, hepatitis C, high alcohol intake, aflatoxin B1 and metabolic syndrome. Most of the time HCC developed on cirrhosis. Consequently, the mechanisms of carcinogenesis of these different risk factors are difficult to separate from the events leading to cirrhosis. In contrast, aflatoxin B1 and hepatitis B have a clear direct oncogenic role through point mutations in the TP53 tumour suppressor gene and i...
Source: Best Practice and Research Clinical Gastroenterology - November 25, 2014 Category: Gastroenterology Source Type: research

Adipose tissues as endocrine target organs
Publication date: August 2014 Source:Best Practice & Research Clinical Gastroenterology, Volume 28, Issue 4 Author(s): Nicolas Lanthier , Isabelle A. Leclercq In the context of obesity, white adipocyte hypertrophy and adipose tissue macrophage infiltration result in the production of pro-inflammatory adipocytokines inducing insulin resistance locally but also in distant organs and contributing to low grade inflammatory status associated with the metabolic syndrome. Visceral adipose tissue is believed to play a prominent role. Brown and beige adipose tissues are capable of energy dissipation, but also of cytokine ...
Source: Best Practice and Research Clinical Gastroenterology - November 25, 2014 Category: Gastroenterology Source Type: research

Bile acids, obesity, and the metabolic syndrome
Publication date: August 2014 Source:Best Practice & Research Clinical Gastroenterology, Volume 28, Issue 4 Author(s): Huijuan Ma , Mary Elizabeth Patti Bile acids are increasingly recognized as key regulators of systemic metabolism. While bile acids have long been known to play important and direct roles in nutrient absorption, bile acids also serve as signalling molecules. Bile acid interactions with the nuclear hormone receptor farnesoid X receptor (FXR) and the membrane receptor G-protein-coupled bile acid receptor 5 (TGR5) can regulate incretin hormone and fibroblast growth factor 19 (FGF19) secretion, chole...
Source: Best Practice and Research Clinical Gastroenterology - November 25, 2014 Category: Gastroenterology Source Type: research

Mechanisms behind the link between obesity and gastrointestinal cancers
Publication date: August 2014 Source:Best Practice & Research Clinical Gastroenterology, Volume 28, Issue 4 Author(s): Herbert Tilg , Alexander R. Moschen Obesity and obesity-related disorders such as non-alcoholic fatty liver disease (NAFLD), metabolic syndrome and type 2 diabetes exhibit an increased risk of developing various gastrointestinal cancers. These malignancies include mainly esophageal, gastric, colorectal, pancreatic and hepatocellular carcinoma. Whereas underlying pathomechanisms remain unclear, chronic inflammation accompanying obesity has evolved in the last years as a crucial contributing factor...
Source: Best Practice and Research Clinical Gastroenterology - November 25, 2014 Category: Gastroenterology Source Type: research

Non-alcoholic fatty liver disease, obesity and the metabolic syndrome
This article details the pathogenesis of NAFLD along with the current state of its diagnosis and treatment. (Source: Best Practice and Research Clinical Gastroenterology)
Source: Best Practice and Research Clinical Gastroenterology - November 25, 2014 Category: Gastroenterology Source Type: research

Impact of diabetes mellitus and metabolic syndrome on acute and chronic on-clopidogrel platelet reactivity in patients with stable coronary artery disease undergoing drug-eluting stent placement
Conclusions Both MS and T2DM were independent predictors of HCPR after clopidogrel loading dose. On clopidogrel maintenance therapy, only T2DM remained an independent predictor. This observation may be clinically relevant in the current era of antiplatelet therapy. (Source: American Heart Journal)
Source: American Heart Journal - November 25, 2014 Category: Cardiology Source Type: research

Phosphoinositides: Key modulators of energy metabolism
This article is part of a Special Issue entitled Phosphoinositides. Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - November 25, 2014 Category: Lipidology Source Type: research

Interplay between 3[prime]-UTR polymorphisms in the vascular endothelial growth factor (VEGF) gene and metabolic syndrome in determining the risk of colorectal cancer in Koreans
Conclusions: Our results implicate that VEGF 1451C > T and 1725G > A may predispose to CRC susceptibility and the genetic contributions may be varied with the presence of MetS. (Source: BMC Cancer)
Source: BMC Cancer - November 25, 2014 Category: Cancer & Oncology Authors: Young JeonJong KimHye ParkHyo JangJung KimJisu OhSo ChongSung KwonEo KimDoyeun OhNam Kim Source Type: research

Efficacy and tolerance of a diabetes specific formula in patients with type 2 diabetes mellitus: An open label, randomized, crossover study
Conclusion The Diabetes specific formula tested in this study showed lower post-meal blood glucose and insulin levels as compared with isocaloric meal. Thus, diabetes specific formula may be an option for diabetic and hyperglycemic patients in need of nutritional support. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Type 2 diabetes mellitus: Role of melatonin and oxidative stress
Publication date: Available online 29 October 2014 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Doddigarla Zephy , Jamal Ahmad Type 2 diabetes mellitus caused by transfer of susceptible immortal gene from parent to progeny in individuals prone, and/or in contribution of factors such as obesity and physical inactivity results in chronic extracellular hyperglycemia due to insulin resistance or impaired glucose tolerance. Hyperglycemia leads to increased production of superoxide radical in mitochondrial electron transport chain, consequently, inhibit glyceraldehyde-3-phosphate...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Diabetic retinopathy – Biomolecules and multiple pathophysiology
Publication date: Available online 24 October 2014 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Haseeb Ahsan One of the major complications in patients with diabetes is diabetic retinopathy (DR), a leading cause of blindness worldwide. It causes visual impairment and finally blindness, a result of long-term accumulated damage to the small blood vessels in the retina. It takes several years before any clinical symptoms of retinopathy appear in diabetic patients. Consequently, glycemic control, blood pressure and lipid-lowering therapy have all shown benefits in reducing the ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Influence of macrolides, nutritional support and respiratory therapies in diabetes and normal glucose tolerance in cystic fibrosis. A retrospective analysis of a cohort of adult and younger patients
Conclusions The anti-inflammatory and immunomodulating effect of macrolides did not seem to affect the β cell function or insulin resistance in patients with cystic fibrosis. The use of inhaled corticosteroids or nutritional supplements have not any influence in the carbohydrate metabolism. Further prospective studies are needed to analyze a potential protective role of macrolides in the development of carbohydrate metabolism alterations in cystic fibrosis. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Association between insulin resistance and risk of complications in children and adolescents with type 1 diabetes
Conclusion In the subgroup of patients with lower eGDR there were more children with lipid disorders, obesity, and worse diabetic control, which, if not corrected, may lead to development of micro- and macrovascular complications. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Possible resting metabolic rate modification by the circulating RBP4 in obese subjects
Conclusion Our findings demonstrated that RBP4 concentration had relation with RMR which was different among obese and non-obese groups. These results may suggest the possible role of RBP4 in alteration of metabolic rate through insulin or other metabolic effects. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Comparative effects of metformin and pioglitazone on fetuin-A and osteoprotegerin concentrations in patients with newly diagnosed diabetes: A randomized clinical trial
Conclusions Metformin and pioglitazone differentially affect fetuin-A and osteoprotegrin levels in diabetic women and men. The level of change may not necessarily be associated with the amelioration of insulin resistance. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

PPAR gamma gene – A review
Publication date: Available online 13 October 2014 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): C. Janani , B.D. Ranjitha Kumari Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense research because ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of type 2 diabetes. There have been described three PPAR isotypes α, δ and γ which have an integrated role in controlling the expression of genes playing key roles in the storage and mobilization of lipids, in glucose metabolism, in morphogenesis and i...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Clinical characteristics and complications of patients with type 2 diabetes attending an urban hospital in Bangladesh
Conclusion Results of the study confirm that even under best clinical settings a great majority Bangladeshi adults with type 2 diabetes have uncontrolled diabetes and a high prevalence of risk factors that might contribute to early development of complications. Early screening of high risk groups and proper management of diabetes is recommended to avoid early complications. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Relationship between serum resistin concentrations with metabolic syndrome and its components in an Iranian population
Conclusion Serum resistin levels are elevated in subjects with MetS and may be associated with the severity of this syndrome. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Burden of diabetes mellitus attributable to demographic levels in Qatar: An emerging public health problem
Conclusion The study findings revealed that diabetes disease burden was considerably high in Qatar, particularly in the working age group. DALYs has been increasing across the years. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Comparison of Ramadan-specific education level in patients with diabetes seen at a Primary and a Tertiary care center of Karachi-Pakistan
Conclusion It was observed that Ramadan-specific education level of patients at Tertiary care center was significantly better compared to patients at Primary care center. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Circulatory adipocytokines and lipid profile variations in type-2 diabetic subjects: Desirable side-effects of antidiabetic drugs
Conclusions Frequently used OHAs significantly improve circulatory levels of adipocytokines. Selecting best treatment option for each patient is a key, and 2012 European Association for the Study of Diabetes (EASD) and ADA guidelines recommend diabetes treatment to be individualized depending on various socioeconomic and lifestyle factors. We recommend regular analysis of circulatory adipocytokines in T2DM patients to help clinicians select the best treatment option to normalize levels of these important therapeutic targets. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Relationship between cardio-ankle vascular index and components of metabolic syndrome in combination with sex and age
Conclusion Male and age were significantly associated with CAVI≥9. Further study is needed to verify the association between CAVI≥9 and MetS components. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

“Diabetes and gum disease: The diabolic duo”
Conclusion Diabetes clearly increases the risk of periodontal diseases, and biologically plausible mechanisms have been demonstrated in abundance. Less clear is the impact of periodontal diseases on glycemic control of diabetes and the mechanisms through which this occurs. It is possible that periodontal diseases may serve as initiators or propagators of insulin resistance in a way similar to obesity, thereby aggravating glycemic control. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Phenotypic heterogeneity of latent autoimmune diabetes in adults identified by body composition analysis
Conclusions: Body composition in LADA patients shows substantial difference, in a gender-dependent way, compared to classic T2D. In women fat deposits tend to accumulate in peripheral regions rather than centrally, whereas in men the distribution is more homogeneous. In addition, central fat depletion in LADA women appears to be a significant predictor of faster progression to insulin dependence. Thus, routine assessment of body composition may help the physician identify LADA patients who require early insulin treatment in order to delay beta-cell exhaustion, as well those with increased CV risk due to excess of truncal a...
Source: Diabetology and Metabolic Syndrome - November 25, 2014 Category: Endocrinology Authors: Giovanni PesAlessandro DelitalaGiuseppe DelitalaAlessandra ErrigoSalvatore CostantinoGiuseppe Fanciulli Source Type: research