Metabolic Syndrome Metabolic Syndrome RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the latest research publications in this category.

The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls
Conclusions: Subjects with chronic kidney disease and metabolic syndrome have higher absolute uric acid values following a fructose tolerance test, but show a relatively smaller percent increase in serum uric acid. Changes in serum uric acid during the fructose tolerance test did not correlate with changes in metabolic parameters, inflammatory mediators or with target organ injury. These studies suggest that acute changes in serum uric acid in response to fructose do not predict the metabolic phenotype or presence of inflammatory mediators in subjects with obesity, metabolic syndrome or chronic kidney disease.Trial registr...
Source: BMC Nephrology - May 3, 2015 Category: Urology & Nephrology Authors: Rafa¿ DonderskiIlona Mi¿kowiec-Wi¿niewskaMarek KretowiczMagdalena GrajewskaJacek ManitiusAnna Kami¿skaRoman JunikJoanna SiódmiakAnna Stefa¿skaGra¿yna Odrow¿¿-SypniewskaAgnieszka PlutaMiguel LanaspaRichard Johnson Source Type: research

Association between n-3 polyunsaturated fatty acids in erythrocytes and metabolic syndrome in Chinese men and women
Conclusion Higher levels of total n-3 PUFAs, EPA, DPA, and DHA, but not of ALA, in erythrocyte membranes are associated with a lower presence of metabolic syndrome in Chinese adults. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - May 2, 2015 Category: Nutrition Source Type: research

12-year old adolescent with super morbid obesity, treated with laparoscopic one anastomosis gastric bypass (loagb/bagua): a case report after 5-year follow-up.
We report a case of a 12 year old patient with super obesity (58.5 kg/m2 of BMI) and metabolic syndrome who underwent LOAGB/BAGUA and monitored during the last 5 year. The patient after five years follow-up maintains a 22.4 kg/m2 of BMI. We consider that LOAGB/ BAGUA could be an effective and safe procedure as a treatment of obesity and comorbidities as well, for adolescent patients. PMID: 25929410 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - May 2, 2015 Category: Nutrition Authors: Carbajo Caballero MA, Vázquez-Pelcastre R, Aparicio-Ponce R, Luque de Leon E, Jimenez JM, Ortiz-Solorzano J, Castro MJ Tags: Nutr Hosp Source Type: research

[systolic pressure, abdominal obesity and body fat, metabolic syndrome predictors in spanish preschoolers].
[SYSTOLIC PRESSURE, ABDOMINAL OBESITY AND BODY FAT, METABOLIC SYNDROME PREDICTORS IN SPANISH PRESCHOOLERS]. Nutr Hosp. 2015;31(n05):2109-2114 Authors: Gutiérrez Hervás AI, Rizo Baeza MM, Martínez Amorós N, Cortés Castell E Abstract OBJECTIVE: The aim of this paper is to determine the presence of metabolic syndrome predictors in 2-to-7- year-old children according to nutrition state. METHOD: A descriptive study with quantitative analysis was conducted in 260 2-to-7-year-old children (135 girls and 125 boys), 66% of the total census. Anthropometric parameters and blood pressure were measured and...
Source: Nutricion Hospitalaria - May 2, 2015 Category: Nutrition Authors: Gutiérrez Hervás AI, Rizo Baeza MM, Martínez Amorós N, Cortés Castell E Tags: Nutr Hosp Source Type: research

Hepatic inflammatory biomarkers and its link with obesity and chronic diseases.
CONCLUSION: This review integrates the knowledge concerning the possible interactions of inflammatory mediators, in isolation or in conjunction, with obesity and chronic diseases, since these biomarkers play different functions and follow diverse biochemical routes in human body metabolism. PMID: 25929362 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - May 2, 2015 Category: Nutrition Authors: Pinheiro Volp AC, Santos Silva FC, Bressan J Tags: Nutr Hosp Source Type: research

Abdominal obesity: a marker of ectopic fat accumulation
In the early 1980s, we analyzed the metabolic profile of 930 men and women and concluded that an abdominal distribution of fat for a given BMI is associated with increased insulin resistance and risk of developing type 2 diabetes and cardiovascular disease. The correlation between abdominal fat and metabolic dysfunction has since been validated in many studies, and waist circumference is now a criterion for the diagnosis of metabolic syndrome. Several mechanisms for this relationship have been postulated; however, we now know that visceral fat is only one of many ectopic fat depots used when the subcutaneous adipose tissue...
Source: Journal of Clinical Investigation - May 2, 2015 Category: Biomedical Science Authors: Ulf Smith Source Type: research

Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1.
Authors: Moon H, Ruelcke JE, Choi E, Sharpe LJ, Nassar ZD, Bielefeldt-Ohmann H, Parat MO, Shah A, Francois M, Inder KL, Brown AJ, Russell PJ, Parton RG, Hill MM Abstract Obesity and metabolic syndrome are associated with several cancers, however, the molecular mechanisms remain to be fully elucidated. Recent studies suggest that hypercholesterolemia increases intratumoral androgen signaling in prostate cancer, but it is unclear whether androgen-independent mechanisms also exist. Since hypercholesterolemia is associated with advanced, castrate-resistant prostate cancer, in this study, we aimed to determine whether a...
Source: Oncotarget - May 2, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Omega-3 fatty acids in first-episode schizophrenia - a randomized controlled study of efficacy and relapse prevention (OFFER): rationale, design, and methods
This study has been registered at Clinical with the following number: NCT02210962. (Source: BMC Psychiatry)
Source: BMC Psychiatry - May 2, 2015 Category: Psychiatry Authors: Tomasz Pawe¿czykMarta GrancowMagdalena Kotlicka-AntczakEl¿bieta TrafalskaPiotr G¿bskiJanusz SzemrajNatalia ¿urnerAgnieszka Pawe¿czyk Source Type: research

Early bioprosthesis failure: report of three cases and literature review.
CONCLUSIONS: EBF is a rare but serious complication. The cause of EBF is complex. Appropriate preventive measures should be developed according to the condition of the patient. PMID: 25924033 [PubMed - in process] (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - May 1, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Zhao A, Ben Z, Fan Y, Xiaohong L, Zhiyun X Tags: Heart Surg Forum Source Type: research

Actions of Adjunctive Nutritional Antioxidants in Periodontitis and Prevalent Systemic Inflammatory Diseases.
Authors: El-Shinnawi U, Soory M Abstract Common risk markers for periodontitis and prevalent systemic comorbidities indicate similarities in their progression and molecular mechanisms involved. Resultant pro-oxidant disease profiles provide scope for attenuating their pathogeneses with appropriate adjunctive antioxidants. Levels of oxidative stress markers 8-hydroxy-deoxguanosine (8-HOdG) and malondialdehyde (MDA) are significantly higher in periodontitis and other chronic inflammatory conditions. There is a clear link between periodontitis and diseases associated with significant systemic inflammatory loading, suc...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 1, 2015 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Metabolic Syndrome Is an Important Concept in Therapeutic Decision-Making
Publication date: May 2015 Source:Canadian Journal of Cardiology, Volume 31, Issue 5 Author(s): David Fitchett Traditional risk factors can underestimate the true risk of developing atherosclerotic cardiovascular disease. Abdominal obesity is associated with a cluster of risk factors that include dyslipidemia, dysglycemia, and hypertension, termed metabolic syndrome (MS). The presence of MS increases cardiovascular risk 50%-100% beyond that defined according to traditional risk factors, and increases the risk of developing type 2 diabetes. Recognition of patients with MS is important to: (1) identify patients at increase...
Source: Canadian Journal of Cardiology - May 1, 2015 Category: Cardiology Source Type: research

Metabolic Syndrome Sinkholes: What to Do When Occam's Razor Gets Blunted
Publication date: May 2015 Source:Canadian Journal of Cardiology, Volume 31, Issue 5 Author(s): Ross D. Feldman , Todd J. Anderson , Rhian M. Touyz The real promise of the metabolic syndrome concept was the opportunity to elucidate a singular common mechanism for its component abnormalities and consequently a singular therapy. That promise has not produced. This relates to the following considerations: (1) metabolic syndrome remains a syndrome not a disease, (2) its diagnosis offers little more than what can be determined by measuring waist circumference, (3) risk assessment is not improved by the diagnosis of metabolic ...
Source: Canadian Journal of Cardiology - May 1, 2015 Category: Cardiology Source Type: research

Contemporary Management and Control of Uncomplicated Hypertension in Canada: Insight From the Primary Care Audit of Global Risk Management (PARADIGM) Study
Conclusions PARADIGM demonstrated that CVD risk factors are prevalent in Canadians with uncomplicated hypertension. BP control was modest (57.4%) and was lowest in patients prescribed diuretic monotherapy and in those at highest CVD risk. Despite the success of national hypertension strategies, enhanced efforts are warranted to improve BP control in Canada. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 1, 2015 Category: Cardiology Source Type: research

Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring
Obesity and type 2 diabetes are increasingly prevalent across all demographics. Paternal obesity in humans and rodents can program obesity and impair insulin sensitivity in female offspring. It remains to be determined whether these perturbed offspring phenotypes can be improved through targeted lifestyle interventions in the obese father. Using a mouse model, we demonstrate that diet or exercise interventions for 8 wk (2 rounds of spermatogenesis) in obese founder males restores insulin sensitivity and normalized adiposity in female offspring. Founder diet and/or exercise also normalizes abundance of X-linked sperm microR...
Source: AJP: Endocrinology and Metabolism - May 1, 2015 Category: Endocrinology Authors: McPherson, N. O., Owens, J. A., Fullston, T., Lane, M. Tags: Articles Source Type: research

Diabetic Foot Ulcer- A review on pathophysiology, classification and microbial etiology
Publication date: Available online 29 April 2015 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Saba Noor , Mohammad Zubair , Jamal Ahmad As the prevalence of diabetes is increasing globally, secondary complications associated to this endocrinal disorder are also ascending. Diabetic foot ulcers are potentially mortifying complications. Disruption of harmony in glucose homeostasis causes hyperglycemic status results in activation of certain metabolic pathways which in their abnormal state subsequently that lead to development of vascular insufficiency, nerve damages headed by ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 1, 2015 Category: Endocrinology Source Type: research

The impact of thiamine supplementation on blood pressure, serum lipids and C-reactive protein in individuals with hyperglycemia: a randomised, double – blind cross-over trial
Conclusion/interpretation High dose thiamine supplementation may have beneficial effects on the blood pressure of individuals with hyperglycemia at early stages, and may have a role in the prevention of further vascular complications. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12611000051943 (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 1, 2015 Category: Endocrinology Source Type: research

Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes
Conclusions The hepatokine FGF21 exerts weak lipogenic and anti-adipogenic actions and marked adiponectin-suppressive and leptin and interleukin-6 release-promoting effects in human differentiating preadipocytes. Together with the higher serum concentrations in MUHO subjects, our findings reveal FGF21 as a circulating factor promoting the development of metabolically unhealthy adipocytes. (Source: Molecular Metabolism)
Source: Molecular Metabolism - May 1, 2015 Category: Endocrinology Source Type: research

Prolactin anterior pituitary expression and circulating levels are reduced in obese and diabetic rats: role of TGF-{beta} and TNF-{alpha}
The levels of the hormone prolactin (PRL) are reduced in the circulation of patients with Type 2 diabetes and in obese children, and lower systemic PRL levels correlate with an increased prevalence of diabetes and a higher risk of metabolic syndrome. The secretion of anterior pituitary (AP) PRL in metabolic diseases may be influenced by the interplay between transforming growth factor β (TGF-β) and tumor necrosis factor α (TNF-α), which inhibit and can stimulate AP PRL synthesis, respectively, and are known contributors to insulin resistance and metabolic complications. Here, we show that TGF-β a...
Source: AJP: Regulatory, Integrative and Comparative Physiology - May 1, 2015 Category: Physiology Authors: Lemini, M., Ruiz-Herrera, X., Ledesma-Colunga, M. G., Diaz-Lezama, N., De los Rios, E. A., Lopez-Barrera, F., Mendez, I., Martinez de la Escalera, G., Macotela, Y., Clapp, C. Tags: Hormones, Reproduction and Development Source Type: research

Nutraceuticals: Definition and Epidemiological Rationale for Their Use in Clinical Practice
Abstract Cardiometabolic risk factors, such as hypercholesterolemia, hypertriglyceridemia, metabolic syndrome, diabetes, and arterial hypertension, are major predictors of the premature development of cardiovascular diseases (CVD). Since CVD prevention needs a life-course approach, beyond dietary and pharmacological treatment, non-pharmacological treatment should be considered an important alternative for patients in primary prevention with mild–moderate cardiometabolic risk factors at low-moderate global risk of CVD. Several functional foods and nutraceuticals are efficacious, safe and well tolerated. However, ...
Source: High Blood Pressure and Cardiovascular Prevention - April 30, 2015 Category: Cardiology Source Type: research

Persistent organic pollutants as risk factors for type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a major and fast growing public health problem. Although obesity is considered to be the main driver of the pandemic of T2DM, a possible contribution of some environmental contaminants, of which persistent organic pollutants (POPs) form a particular class, has been suggested. POPs are organic compounds that are resistant to environmental degradation through chemical, biological, and photolytic processes which enable them to persist in the environment, to be capable of long-range transport, bio accumulate in human and animal tissue, bio accumulate in food chains, and to have potential sign...
Source: Diabetology and Metabolic Syndrome - April 30, 2015 Category: Endocrinology Authors: Elvis NgwaAndre-Pascal KengneBarbara Tiedeu-AtoghoEdith-Pascale Mofo-MatoEugene Sobngwi Source Type: research

Effects of 1-year yoga on cardiovascular risk factors in middle-aged and older adults with metabolic syndrome: a randomized trial
Conclusion: These results suggest that yoga exercise improves the cardiovascular risk factors including central obesity and blood pressure in middle-aged and older adults with MetS. These findings support the complementary beneficial role of yoga in managing MetS. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - April 30, 2015 Category: Endocrinology Authors: Parco SiuAngus YuIris BenzieJean Woo Source Type: research

Cardiometabolic risk factors in the Agarwal business community in India: Jaipur Heart Watch-6
Conclusions Cardiometabolic risk factors are highly prevalent in the Agarwal business community. Prevalence is greater in subjects with low educational status. (Source: Indian Heart Journal)
Source: Indian Heart Journal - April 30, 2015 Category: Cardiology Source Type: research

Relationship Between Insulin-like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients with Aortic Stenosis
Conclusions In this study, we documented that lower IGFBP-2 levels are independently associated with lower SVi, a powerful predictor of worse outcomes in the mild to moderate AS population. Teaser In aortic stenosis (AS) patients, LV remodeling and function vary extensively from one patient to another. Considering the associations between circulating IGFBP-2 and markers of the metabolic syndrome, the aim of the study was to examine the relationship between circulating IGFBP-2 and left ventricle (LV) pump function as measured by stroke volume index in AS patients with preserved LV ejection fraction. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - April 30, 2015 Category: Cardiology Source Type: research

Increased adipose tissue secretion of Fetuin-A, lipopolysaccharide-binding protein and high–mobility group box protein 1 in metabolic syndrome
We examined AT secretion of the hepatokine, Fetuin-A, LBP, sCD14 and HMGB-1, and toll-like receptor 2 and 4 protein levels in MetS and controls. (Source: Atherosclerosis)
Source: Atherosclerosis - April 30, 2015 Category: Cardiology Authors: Ishwarlal Jialal, Sridevi Devaraj, Ahmed Bettaieb, Fawaz Haj, Beverley Adams-Huet Source Type: research

Regulation of white adipogenesis and its relation to ectopic fat accumulation and cardiovascular risk
The subcutaneous adipose tissue (SAT) is the largest and least harmful adipose depot to store excess lipids. However, SAT has a limited ability to expand and recruit new cells. When the SAT adipose cells become expanded (hypertrophic obesity), this leads to a dysregulated and dysfunctional SAT and the accumulation of ectopic fat in many depots. Increased hepatic and visceral fat are well-known ectopic fat depots and reflect the inability of SAT to accommodate excess fat. Ectopic fat also leads to paracrine and endocrine effects and promotes the metabolic profile of the Metabolic Syndrome. (Source: Atherosclerosis)
Source: Atherosclerosis - April 30, 2015 Category: Cardiology Authors: Birgit Gustafson, Ulf Smith Tags: Review Source Type: research

Abstract P1-09-21: Metabolic syndrome is prevalent in women with newly diagnosed breast cancer
Purpose: We estimate the prevalence of metabolic syndrome (MetSyn) among women with newly diagnosed breast cancer and explore potential risk factors. Methods: From January 2012 to May 2014, women with newly diagnosed localized breast cancer were enrolled into a longitudinal survivorship study. At baseline, results of physical exam, use of concomitant medications, serum lipid profile and vitamin D were obtained from the medical record, while quality of life variables were measured via questionnaires in English. MetSyn was defined as at least 3 of 5 criteria: central obesity (BMI >30 or waist >=88 cm); triglycerides >=150 mg...
Source: Cancer Research - April 30, 2015 Category: Cancer & Oncology Authors: Wong, L. C., Behrendt, C., Smith, R., Mortimer, J. E. Tags: Poster Session Abstracts Source Type: research

Abstract P6-08-42: Association of metabolic syndrome, its components and multigene assays for recurrence risk
Conclusions and Implications: The association of MS and its components differs for the 70-GS and RS assays. There is significant association between MS (and DM, HTN, obesity) and RS, but no association with 70-GS. Patients with MS (and components) are more likely to have a biology (low RS) known to have less chemotherapy benefit. Given the reported impact of MS on BC incidence and outcomes along with the global increased MS incidence, the MS may have profound impact on BC biology and treatment outcomes in the coming years. It is also possible that multigene assays currently in use for prognosis and prediction may need refi...
Source: Cancer Research - April 30, 2015 Category: Cancer & Oncology Authors: Mai, H. P., Kliethermes, S., Jain, S., Lo, S. S., Gaynor, E. R., Albain, K. S., Robinson, P. Tags: Poster Session Abstracts Source Type: research

Human apolipoprotein B transgenic SHR/NDmcr-cp rats show exacerbated kidney dysfunction.
Authors: Asahina M, Shimizu F, Ohta M, Takeyama M, Tozawa R Abstract Nephropathy frequently co-occurs with metabolic syndrome in humans. Metabolic syndrome is a cluster of metabolic diseases including obesity, diabetes, hypertension, and dyslipidemia, and some previous studies revealed that dyslipidemia contributes to the progression of kidney dysfunction. To establish a new nephropathy model with metabolic syndrome, we produced human apolipoprotein B (apoB) transgenic (Tg.) SHR/NDmcr-cp (SHR-cp/cp) rats, in which dyslipidemia is exacerbated more than in an established metabolic syndrome model, SHR-cp/cp rats. Huma...
Source: Experimental Animals - April 29, 2015 Category: Research Tags: Exp Anim Source Type: research

Streptozotocin-induced diabetes disrupts the body temperature daily rhythm in rats
Background: In mammals, the temperature rhythm is regulated by the circadian pacemaker located in the suprachiasmatic nuclei, and is considered a “marker rhythm”. Melatonin, the pineal gland hormone, is a major regulator of the endogenous rhythms including body temperature. Its production is influenced by many factors, such as type 1 diabetes mellitus. In rats, diabetes leads to hypothermia and reduced melatonin synthesis; insulin treatment reestablishes both.AimTo study the body temperature daily rhythm of diabetic animals and the effects of insulin and/or melatonin treatment on its structure. Methods: We studied the ...
Source: Diabetology and Metabolic Syndrome - April 29, 2015 Category: Endocrinology Authors: Angela Ramos-LoboDaniella BuonfiglioJosé Cipolla-Neto Source Type: research

The Association of Fitness With Reduced Cardiometabolic Risk Among Smokers
Conclusions Moderate to high cardiorespiratory fitness among smokers is associated with a reduced likelihood of developing certain cardiovascular disease risk factors and metabolic syndrome. (Source: American Journal of Preventive Medicine)
Source: American Journal of Preventive Medicine - April 29, 2015 Category: Global & Universal Source Type: research

Pathophysiological mechanisms of increased cardiometabolic risk in people with schizophrenia and other severe mental illnesses
Publication date: May 2015 Source:The Lancet Psychiatry, Volume 2, Issue 5 Author(s): David C Henderson , Brenda Vincenzi , Nicolas V Andrea , Melissa Ulloa , Paul M Copeland Patients with schizophrenia have increased mortality and morbidity compared with the general population. These patients have a 20-year shorter lifespan than peers without schizophrenia, mainly due to premature cardiovascular disease, suicide, and cancer. Patients with severe mental illness are at increased risk for cardiovascular disease related to increased incidence of diabetes, hypertension, smoking, poor diet, obesity, dyslipidaemia, metabolic s...
Source: The Lancet Psychiatry - April 29, 2015 Category: Psychiatry Source Type: research

Importance of Sex and Gender in atherosclerosis and cardiovascular disease
In this special issue of the journal, there are papers on bone health and coronary artery calcification, age and sex differences in the effect of parental stroke on the progression of carotid intima-media thickness, macrophage subsets in the adipose tissue by sex and by reproductive age of women, uric acid levels and metabolic syndrome, sex differences in cardiovascular risk factors and disease prevention, severity of stable coronary artery disease and its biomarkers, cardiovascular disease and autoimmune diseases genetics of cardiovascular disease, outcome after CABG; association of serum phosphorus with subclinical ather...
Source: Atherosclerosis - April 29, 2015 Category: Cardiology Authors: J.David Spence, Louise Pilote Tags: Invited commentary Source Type: research

Health-related quality of life and diabetes
Sepúlveda E, Poínhos R, Constante M, Pais-Ribeiro J, Freitas P, Carvalho D (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 28, 2015 Category: Endocrinology Source Type: research

Relationship between non-alcoholic fatty liver disease and benign prostatic hyperplasia/lower urinary tract symptoms: new insights from an Italian cross-sectional study
Conclusions Non-alcoholic fatty liver disease (NAFLD) subjects have higher risk of LUTS. The presence of FLI ≥40 can be used to predict subjects at high risk of LUTS. (Source: World Journal of Urology)
Source: World Journal of Urology - April 28, 2015 Category: Urology & Nephrology Source Type: research

Key Points of the Japanese Society of Hypertension Guidelines for the Management of Hypertension in 2014
The Japanese Society of Hypertension (JSH) published the new JSH guidelines for the management of hypertension in 2014, which is the revision of the JSH guidelines of 2009. The primary objective of the guideline is to provide physicians the standard treatment strategy of hypertension to prevent the hypertension-related target organ damage and cardiovascular events. The management of hypertension should be performed in hypertensive patients with a blood pressure of ≥140/90 mm Hg. As Asians have a higher prevalence of stroke than of coronary artery disease and stroke is more steeply associated with the level of blood press...
Source: Pulse - April 28, 2015 Category: Cardiology Source Type: research

Su1487 Impact of Diabetes Mellitus on Postoperative Bleeding After Endoscopic Submucosal Dissection for Esophago-Gastric Tumor
Metabolic syndrome has been more widespread due to a rise in obesity rates among adults. We have thus increased opportunities to perform endoscopic submucosal dissection (ESD) for patients with esophago-gastric tumors complicated with type 2 diabetes (DM), hypertension (HT) and hyperlipidemia (HL). These patients are at risk for atherosclerosis and often taking antithrombotic agents, which are likely to be risk for bleeding in ESD. However, the potential risk of post-ESD bleeding in these patients was still unclear. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 28, 2015 Category: Gastroenterology Authors: Yu Sasaki, Yasuhiko Abe, Kazuya Yoshizawa, Takeshi Sato, Eiki Nomura, Daisuke Iwano, Makoto Yagi, Kazuhiro Sakuta, Rika Shibuya, Naoko Mizumoto, Nana Kanno, Shoichi Nishise, Yoshiyuki Ueno Tags: Sunday abstract Source Type: research

Recommendations on complementary feeding for healthy, full-term infants
Weaning (or introduction of complementary feeding) is a special and important moment in the growth of a child, both for the family and the infant itself, and it can play a major role in the child’s future health. Throughout the years, various weaning modes have come in succession, the latest being baby-led weaning; the timing for introducing foods and the requirements of which sort of nutrient for weaning have also changed over time. Furthermore, the role played by nutrition, especially in the early stages of life, for the onset of later non-communicable disorders, such as diabetes, obesity or coeliac disease has also be...
Source: Italian Journal of Pediatrics - April 28, 2015 Category: Pediatrics Authors: Patrizia AlvisiSandra BrusaStefano AlboresiSergio AmarriPaolo BottauGiovanni CavagniBarbara CorradiniLinda LandiLeonardo LoroniMiris MaraniIrene OstiCarlotta Povesi-DascolaCarlo CaffarelliLuca ValerianiCarlo Agostoni Source Type: research

Anti-hypertensive Drug Treatment of Patients with and the Metabolic Syndrome and Obesity: a Review of Evidence, Meta-Analysis, Post hoc and Guidelines Publications
Abstract Epidemiological studies have shown an increasing prevalence of obesity and the metabolic syndrome worldwide. Lifestyle modifications that include dietary changes, weight reduction, and exercise are the cornerstones in the treatment of this pathology. However, adherence to this approach often meets with failure in clinical practice; therefore, drug therapy should not be delayed. The ideal pharmacological antihypertensive regimen should target the underlying mechanisms involved in this syndrome, including sympathetic activation, increased renal tubular sodium reabsorption, and overexpression of the renin-a...
Source: Current Hypertension Reports - April 28, 2015 Category: Primary Care Source Type: research

Afamin — A pleiotropic glycoprotein involved in various disease states
Publication date: 15 June 2015 Source:Clinica Chimica Acta, Volume 446 Author(s): Hans Dieplinger , Benjamin Dieplinger The human glycoprotein afamin was discovered as the fourth member of the albumin gene family. Despite intense research over the last 20years, our knowledge of afamin's physiological or pathophysiological functions is still very limited. Circulating afamin is primarily of hepatic origin and abundant concentrations are found in plasma, cerebrospinal, ovarian follicular and seminal fluids. In vitro binding studies revealed specific binding properties for vitamin E. A previously performed analytical charact...
Source: Clinica Chimica Acta - April 28, 2015 Category: Laboratory Medicine Source Type: research

Impaired immune phenotype of circulating endothelial-derived microparticles in patients with metabolic syndrome and diabetes mellitus
Conclusion We found that patients with T2DM and MetS may be distinguished by predominantly appearing phenotypes of circulating EMPs associated with pro-inflammatory cytokine overproduction. Elevated CD31+/annexin V+ EMPs to CD62E+ EMPs ratio is an indicator of impaired immune phenotype of EMPs, which allows determining the pattern of EMPs in dysmetabolic disorder patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 28, 2015 Category: Endocrinology Source Type: research

The Diabetic Foot
Publication date: Available online 27 April 2015 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Jamal Ahmad Diabetic foot problems are responsible for nearly 50% of all diabetes-related hospital bed –days. Approximately 10-15% of diabetic patients developed foot ulcers at some state in their life and 15% of all load in amputations are performed in patients with diabetes. There is a need to provide extensive education to both primary care physicians and the patients regarding the relationship between glucose control and complications encountered in the foot and ankle. The ma...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - April 28, 2015 Category: Endocrinology Source Type: research

Association of HSD11B1 polymorphic variants and adipose tissue gene expression with metabolic syndrome, obesity and type 2 diabetes mellitus: a systematic review
The HSD11B1 gene is highly expressed in abdominal adipose tissue, and the enzyme it encodes catalyzes the interconversion of inactive cortisone to hormonally active cortisol. Genetic abnormalities of HSD11B1 have been associated with the development of abnormal glucose metabolism and body fat distribution. To systematically review studies evaluating the association of HSD11B1 gene expression in abdominal adipose tissue and HSD11B1 polymorphisms with obesity, the metabolic syndrome (MetS), and type 2 diabetes (T2DM), we conducted a search in MEDLINE, SCOPUS, and Cochrane Library databases in April 2015. The inclusion criter...
Source: Diabetology and Metabolic Syndrome - April 28, 2015 Category: Endocrinology Authors: Filipe do NascimentoVanessa PiccoliMayara BeerAnize von FrankenbergDaisy CrispimFernando Gerchman Source Type: research

Bergamot Polyphenol Fraction prevents Non-alcoholic Fatty Liver Disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome
Non-alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in industrialized countries. Defective autophagy of lipid droplets in hepatocytes, also known as lipophagy, has recently been identified as a possible pathophysiological mechanism of NAFLD. Experimental and epidemiological evidence suggest that dietary polyphenols may prevent NAFLD. To address this hypothesis and analyze the underlying mechanisms, we supplemented Bergamot Polyphenol Fraction (BPF) to cafeteria (CAF) diet-fed rats, a good model for pediatric metabolic syndrome and NAFLD. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 28, 2015 Category: Biochemistry Authors: Maddalena Parafati, Antonella Lascala, Valeria Maria Morittu, Francesca Trimboli, Antonia Rizzuto, Elvira Brunelli, Francesca Coscarelli, Nicola Costa, Domenico Britti, James Ehrlich, Ciro Isidoro, Vincenzo Mollace, Elzbieta Janda Source Type: research

Low‐fasting triglyceride levels are associated with non‐invasive markers of advanced liver fibrosis among adults in the United States
ConclusionsFasting triglyceride levels were inversely associated with liver fibrosis indicators in American adults, especially among white men. Our findings suggest that sequential lipid measurements may serve as a useful disease marker in the management of chronic liver disease patients. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - April 27, 2015 Category: Drugs & Pharmacology Authors: Z. G. Jiang, Y. Tsugawa, E. B. Tapper, M. Lai, N. Afdhal, S. C. Robson, K. J. Mukamal Tags: Original Article Source Type: research

Predictability of 1‐h postload plasma glucose concentration: A 10‐year retrospective cohort study
Conclusions1hPG is a good predictor of type 2 diabetes in NGR subjects, and the best cut‐off point is 8.85 mmol/L. Some tendency indicates that NGR subjects with 1hPG ≥8.85 mmol/L are more prone to metabolic syndrome and carotid atherosclerosis. In this retrospective cohort study, we evaluated the predictability and cutoff point of 1hPG in predicting T2DM in normal glucose regulation (NGR) subjects, and the long‐term prognosis of NGR subjects with elevated 1hPG in glucose metabolism, kidney function, metabolic states, and atherosclerosis. We found that 1hPG was a good predictor of T2DM in NGR subjects, and the bes...
Source: Journal of Diabetes Investigation - April 27, 2015 Category: Endocrinology Authors: Lifen Kuang, Zhimin Huang, Zhenzhen Hong, Ailing Chen, Yanbing Li Tags: Original Article Source Type: research

Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency
Conclusions Traditional Chinese medicines Yi Tang Kang could regulate glucose and lipid metabolism in rats with spleen deficiency syndrome. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - April 27, 2015 Category: Tropical Medicine Source Type: research

Antioxidant Mechanisms in Nonalcoholic Fatty Liver Disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) represents a broad spectrum of histological abnormalities with clinical presentations ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH). Some NAFLD patients may progress to cirrhosis and ultimately hepatocellular carcinoma (HCC). Hepatic steatosis, the hallmark of NAFLD, is defined by the accumulation of triglycerides (TGs) in more than 5% of the hepatocytes. NASH is characterized by inflammation along with variable degrees of fibrosis in addition to steatosis. NAFLD has been considered to be the hepatic manifestation of metabolic syndrome (MS), ...
Source: Current Drug Targets - April 27, 2015 Category: Drugs & Pharmacology Authors: Wensheng L, Baker SS, Baker RD, Zhu L Tags: Curr Drug Targets Source Type: research

Metabolic syndrome among psychiatric inpatients with schizophrenia in Indonesia.
This study aimed to investigate the prevalence of MetS among inpatients with schizophrenia in Indonesia. Eighty-six hospitalised psychiatric patients with schizophrenia were randomly recruited, and underwent physical examination including a blood test. MetS was assessed based on the International Diabetes Federation (IDF) criteria for South Asia. Among the sample, only eight patients (9.3%) met the IDF criteria for MetS. Women have a higher rate of MetS than men (23.8% vs 4.6%; p=0.02). Reduced high-density lipoprotein (HDL) cholesterol was the most frequent (81.4%) metabolic abnormality among them, followed by central obe...
Source: Asian Journal of Psychiatry - April 26, 2015 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Changes in malondialdehyde and C-reactive protein concentrations after lifestyle modification are related to different metabolic syndrome-associated pathophysiological processes
Conclusions Pro-oxidant and pro-inflammatory states of MetS can be attenuated after lifestyle modification if glucose metabolism homeostasis were recovered and if liver inflammation were reduced, respectively. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - April 26, 2015 Category: Endocrinology Source Type: research

Wound healing effects of dipeptidyl peptidase-4 inhibitors: an emerging concept in management of diabetic foot ulcer –a review
Conclusion DPP-4 inhibitors show promise in the local wound healing of diabetic foot ulcers in addition to its already established glycaemic control. In the light of high rate of amputations due to non-healing ulcers with profound psychological and economical liability, more investigations on the usefulness of DPP-4 inhibitors in the high risk diabetes population are needed. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - April 26, 2015 Category: Endocrinology Source Type: research