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The prevalence of metabolic syndrome in people with severe mental illness: a mediation analysis
Conclusions SMI remained prominent in increasing the likelihood of MetS in this low prevalence population, and putative determinants of MetS were common to people with SMI and to controls. Explanations for high MetS rates in SMI may lie in health behaviours other than smoking. (Source: Social Psychiatry and Psychiatric Epidemiology)
Source: Social Psychiatry and Psychiatric Epidemiology - October 21, 2014 Category: Psychiatry Source Type: research

A randomized controlled trial on a multicomponent intervention for overweight school-aged children - Copenhagen, Denmark
Background: Obesity amongst children is a growing problem worldwide. In contrast to adults, little is known on the effects of controlled weight loss on components of the metabolic syndrome in children. The primary aim of the study was to evaluate the effects of a 20-week exercise and diet guidance intervention on body mass index (BMI) in a group of overweight children. Our hypothesis was an observed reduction in BMI and secondarily in body fat content, insulin insensitivity, and other components of the metabolic syndrome in the intervention group. Methods: School children from Copenhagen were randomly allocated to an inter...
Source: BioMed Central - October 21, 2014 Category: Journals (General) Authors: Nina Majlund Harder-LauridsenNina Marie BirkMathias Ried-LarsenAnders JuulLars Bo AndersenBente Klarlund PedersenRikke Krogh-Madsen Source Type: research

Risk of incident diabetes in patients with gout: A cohort study
Conclusion: Gout was associated with an increased risk of developing DM compared with osteoarthritis after adjusting for potential confounders, and the risk associated with gout was higher among women than men. © 2014 American College of Rheumatology. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 20, 2014 Category: Rheumatology Authors: Seoyoung C. Kim, Jun Liu, Daniel H. Solomon Tags: Full Length Source Type: research

Metabolic syndrome‐like components and prostate cancer risk: results from the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study
ConclusionWhen biopsies are largely PSA level independent, men with an initial elevated PSA level and a previous negative biopsy, and multiple MetS‐like components were at an increased risk of high‐grade prostate cancer, suggesting the link between MetS‐like components and high‐grade prostate cancer is unrelated to a lowered PSA level. (Source: BJU International)
Source: BJU International - October 20, 2014 Category: Urology & Nephrology Authors: Katharine N. Sourbeer, Lauren E. Howard, Gerald L. Andriole, Daniel M. Moreira, Ramiro Castro‐Santamaria, Stephen J. Freedland, Adriana C. Vidal Tags: Urological Oncology Source Type: research

Alcohol consumption amplifies immune suppression induced by ultraviolet radiation
Psoriasis is a chronic, autoimmune-mediated, multisystem, inflammatory disorder that effects approximately 2% of the population. While psoriasis is not considered lethal, comorbidities include metabolic syndrome, atherosclerotic cardiovascular disease, depression, poor self-esteem, and self-destructive habits such as obesity, smoking and excess alcohol consumption. Moderate to severe psoriasis correlates with an increased risk of death, with heavy alcohol use acting as a major contributor to this excessive mortality. (Source: Alcohol)
Source: Alcohol - October 19, 2014 Category: Addiction Authors: R.M. Brand, M.C. Paglia, L.D. Falo Source Type: research

Skeletal muscle glucose metabolism and inflammation in the development of the metabolic syndrome.
Abstract Insulin resistance and metabolic dysfunction in skeletal muscle play a major role in the development of the metabolic syndrome and type 2 diabetes. Numerous mechanisms have been proposed to explain the pathophysiology of obesity-linked metabolic dysfunction and this review will focus on the contributing role of adiponectin and inflammation. The beneficial effects of adiponectin on both insulin action and inflammation are now well documented and will be reviewed. More recent work provided new insights into adiponectin signaling mechanisms. The development of strategies to mimic adiponectin action holds prom...
Source: ENDOCR REV - October 19, 2014 Category: Endocrinology Authors: Marette A, Liu Y, Sweeney G Tags: Rev Endocr Metab Disord Source Type: research

Mobile health, exercise and metabolic risk: a randomized controlled trial
Conclusions: In participants with increased cardiometabolic risk, exercise prescription alone had greater short-term improvements in systolic blood pressure compared to the mHealth intervention, though over 52 weeks, improvements were equal between interventions.Trial registration: ClinicalTrials.gov NCT01944124. (Source: BMC Public Health)
Source: BMC Public Health - October 18, 2014 Category: Consumer Health News Authors: Robert PetrellaMelanie StuckeySheree ShapiroDawn Gill Source Type: research

Attenuated Cerebral Vasodilatory Capacity in Response to Hypercapnia in College‐aged African Americans
In conclusion, these data indicate that AA have attenuated cerebral vascular capacity to hypercapnia when compared with CA.This article is protected by copyright. All rights reserved (Source: Experimental Physiology)
Source: Experimental Physiology - October 18, 2014 Category: Physiology Authors: Chansol Hurr, Kiyoung Kim, Michelle L. Harrison, R. Matthew Brothers Tags: Research Paper Source Type: research

Combined lowering of low grade systemic inflammation and insulin resistance in metabolic syndrome patients treated with
In a clinical pilot study with eleven metabolic syndrome patients, a simultaneous decrease in hs-CRP from 8.85 ± 4.09 to 4.92 ± 2.51 mg/L (-44.4%) (p < 0.0436) and HOMA-IR from 3.07 ± 0.63 to 2.60 ± 0.51 mU/L×mg/dL (-15.3%) (p < 0.0120) as well as a beneficial change of arteriosclerotic, inflammatory and oxidative stress biomarkers were detected after 2-month treatment with Ginkgo biloba. Furthermore, both IL-6 (-12.9%, p < 0.0407) and nanoplaque formation (-14.3%, p < 0.0077) were additionally reduced. (Source: Atherosclerosis)
Source: Atherosclerosis - October 17, 2014 Category: Cardiology Authors: G. Siegel, E. Ermilov, O. Knes, M. Rodríguez Source Type: research

Comorbidity modulates non invasive ventilation-induced changes in breath print of obstructive sleep apnea syndrome patients.
CONCLUSION: We found that BP change after a single night of CPAP largely depends upon comorbidity. Comorbidity likely contributes to phenotypic variability in OSAS population. BP might qualify as a surrogate index of the response to and, later, compliance with CPAP. PMID: 25323296 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 17, 2014 Category: Sleep Medicine Authors: Incalzi RA, Pennazza G, Scarlata S, Santonico M, Vernile C, Cortese L, Frezzotti E, Pedone C, D'Amico A Tags: Sleep Breath Source Type: research

PROPIT: A PROspective comparative clinical study evaluating the efficacy and safety of PITavastatin in patients with metabolic syndrome
ConclusionsEarly statin treatment can be an effective option in obese patients with MS, prediabetes and mild dyslipidaemia with further improvement of cardiovascular risk factors. We could not observe the increase rate of glucose intolerance in statin group. Future longitudinal studies are needed to test the benefits of early statin treatment compared with LSM. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - October 17, 2014 Category: Endocrinology Authors: Sung Hee Choi, Soo Lim, Eun Shil Hong, Ji A Seo, Cheol‐Young Park, Jung Hyun Noh, Ji Oh Mok, Ki Young Lee, Jong Sook Park, Dae Jung Kim, Chang Beom Lee, Sung Rae Kim, Hak Chul Jang Tags: Original Article Source Type: research

Provision of healthy school meals does not affect the metabolic syndrome score in 8-11-year-old children, but reduces cardiometabolic risk markers despite increasing waist circumference.
In conclusion, the school meals did not affect the MetS score in 8-11-year-olds, as small improvements in blood pressure, TAG concentrations and insulin resistance were counterbalanced by slight undesired effects on waist circumference and HDL-cholesterol concentrations. PMID: 25323030 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - October 17, 2014 Category: Nutrition Authors: Damsgaard CT, Dalskov SM, Laursen RP, Ritz C, Hjorth MF, Lauritzen L, Sørensen LB, Petersen RA, Andersen MR, Stender S, Andersen R, Tetens I, Mølgaard C, Astrup A, Michaelsen KF Tags: Br J Nutr Source Type: research

Excess body iron and the risk of type 2 diabetes mellitus: a nested case-control in the PREDIMED (PREvention with MEDiterranean Diet) study.
Abstract A prospective nested case-control study within the PREvention with MEDiterranean Diet (PREDIMED) was conducted to evaluate the relationship between excess body Fe (measured as serum ferritin (SF), soluble transferrin receptor (sTfR) and sTfR:ferritin ratio) and the risk of type 2 diabetes mellitus (T2DM) in a Mediterranean population at a high risk of CVD, without T2DM at the start of the study. The study contained 459 subjects, 153 with incident T2DM (cases) and 306 without incident T2DM (controls). The follow-up period was for 6·0 (interquartile range 3·9-6·5) years. For each incident diabetic subject...
Source: The British Journal of Nutrition - October 17, 2014 Category: Nutrition Authors: Arija V, Fernández-Cao JC, Basora J, Bulló M, Aranda N, Estruch R, Martínez-González MA, Salas-Salvadó J Tags: Br J Nutr Source Type: research

Comorbidity modulates non invasive ventilation-induced changes in breath print of obstructive sleep apnea syndrome patients
Conclusion We found that BP change after a single night of CPAP largely depends upon comorbidity. Comorbidity likely contributes to phenotypic variability in OSAS population. BP might qualify as a surrogate index of the response to and, later, compliance with CPAP. (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 16, 2014 Category: Respiratory Medicine Source Type: research

Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress
Endothelial xanthine oxidoreductase (XOR) together with NAD(P)H oxidase and nitric oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO production and vascular function. The oxidative stress generated by these enzymes may induce endothelial dysfunction, leading to atherosclerosis, cardiovascular diseases and metabolic syndrome. XOR activity creates both oxidant and anti-oxidant products that are implicated in the development of hypertension, smoking vascular injury, dyslipidemia and diabetes, which are the main risk factors of atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - October 16, 2014 Category: Cardiology Authors: Maria Giulia Battelli, Letizia Polito, Andrea Bolognesi Tags: Review Source Type: research

The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer.
Abstract Despite increased survivorship among patients, breast cancer remains the most common cancer among women and is the second leading cause of cancer death in women. The magnitude of this problem provides a strong impetus for new chemopreventative strategies and/or lifestyle changes that reduce cancer incidence. It is of significance, therefore, that several studies positively correlate obesity to the development of breast cancer. Importantly, obesity is also highly associated with elevated cholesterol, and cholesterol itself is a risk factor for breast cancer. Furthermore, patients taking statins demonstrate ...
Source: Climacteric - October 16, 2014 Category: Geriatrics Authors: McDonnell DP, Chang CY, Nelson ER Tags: Climacteric Source Type: research

Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial.
Conclusions: Our data suggest that high-dose RSV supplementation positively affects bone, primarily by stimulating formation or mineralization. Future studies of longer duration comprising populations at risk of osteoporosis are needed to confirm these results. PMID: 25322274 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 16, 2014 Category: Endocrinology Authors: Ornstrup MJ, Harsløf T, Kjær TN, Langdahl BL, Pedersen SB Tags: J Clin Endocrinol Metab Source Type: research

Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events.
Abstract The role of circulating microparticles (MP) of different origin and tissue factor (TF)-bearing in overweight and obese patients with and without metabolic syndrome is still a matter of debate. In a case-control study, the presence of hypercoagulability was evaluated in overweight and obese patients by measuring MP, thrombin generation (TG) and FVIIa-AT complexes. Twenty overweight patients (body mass index [BMI] range 25-29.9 kg/m²), 20 with I degree (30-34.9 kg/m²), 20 with II degree (35-39.9 kg/m²) and 20 with III degree obesity (≥ 40 kg/m²) were enrolled and compared to 40 age and gender-matched...
Source: Thrombosis and Haemostasis - October 16, 2014 Category: Hematology Authors: Campello E, Zabeo E, Radu CM, Spiezia L, Gavasso S, Fadin M, Woodhams B, Vettor R, Simioni P Tags: Thromb Haemost Source Type: research

Metabolic syndrome after pregnancies complicated by pre-eclampsia or small for gestational age: a retrospective cohort.
CONCLUSIONS: A history of pre-eclampsia, rather than SGA, was associated with metabolic syndrome, suggesting that it relates to maternal rather than fetal etiology of placental syndrome. PMID: 25318833 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - October 16, 2014 Category: OBGYN Authors: Al-Nasiry S, Ghossein-Doha C, Polman S, Lemmens S, Scholten R, Heidema W, Spaan J, Spaanderman M Tags: BJOG Source Type: research

Aging, the metabolic syndrome, and ischemic stroke: redefining the approach for studying the blood-brain barrier in a complex neurological disease.
Abstract The blood-brain barrier (BBB) has many important functions in maintaining the brain's immune-privileged status. Endothelial cells, astrocytes, and pericytes have important roles in preserving vasculature integrity. As we age, cell senescence can contribute to BBB compromise. The compromised BBB allows an influx of inflammatory cytokines to enter the brain. These cytokines lead to neuronal and glial damage. Ultimately, the functional changes within the brain can cause age-related disease. One of the most prominent age-related diseases is ischemic stroke. Stroke is the largest cause of disability and is thir...
Source: Advances in Pharmacology - October 15, 2014 Category: Drugs & Pharmacology Authors: Lucke-Wold BP, Logsdon AF, Turner RC, Rosen CL, Huber JD Tags: Adv Pharmacol Source Type: research

Effect of the new diagnostic criteria for gestational diabetes mellitus among Japanese women
Conclusions Because the new GDM criteria greatly affect perinatal complications, intervention for GDM starting at an early stage and strict follow-up (especially GDM with obesity) are important for reducing complications as well as the incidence of diabetes and metabolic syndrome in the mother and child. (Source: Diabetology International)
Source: Diabetology International - October 15, 2014 Category: Endocrinology Source Type: research

Pituitary image: pituicytoma
Conclusions Pituicytomas are often difficult to distinguish from other hypothalamic or pituitary lesions. However, their identification would be preferable in a pre-operative setting in order to optimize the work-up and to initiate a proactive management of the expected complications. (Source: Pituitary)
Source: Pituitary - October 14, 2014 Category: Endocrinology Source Type: research

Interarm differences in systolic blood pressure and mortality among US army veterans: aetiological associations and risk prediction in the Vietnam experience study
Conclusions In this non-clinical cohort study, interarm differences in SBP were not associated with mortality after accounting for traditional CVD risk factors. Interarm differences might not be valuable as an additional risk factor for mortality in populations with a low risk of CVD. (Source: European Journal of Preventive Cardiology)
Source: European Journal of Preventive Cardiology - October 14, 2014 Category: Cardiology Authors: White, J., Mortensen, L. H., Kivimaki, M., Gale, C. R., Batty, G. D. Tags: Original scientific papers Source Type: research

Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial.
IMED Study Investigators Abstract BACKGROUND: Little evidence exists on the effect of an energy-unrestricted healthy diet on metabolic syndrome. We evaluated the long-term effect of Mediterranean diets ad libitum on the incidence or reversion of metabolic syndrome. METHODS: We performed a secondary analysis of the PREDIMED trial - a multicentre, randomized trial done between October 2003 and December 2010 that involved men and women (age 55-80 yr) at high risk for cardiovascular disease. Participants were randomly assigned to 1 of 3 dietary interventions: a Mediterranean diet supplemented with extra-virgin oliv...
Source: cmaj - October 14, 2014 Category: Journals (General) Authors: Babio N, Toledo E, Estruch R, Ros E, Martínez-González MA, Castañer O, Bulló M, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Sorlí JV, Salas-Salvadó J, for the PRE Tags: CMAJ Source Type: research

GW25-e5299 Risk factors associated with hypertension control in metabolic syndrome: the data from a cross-sectional survey in northern Chinese population
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e5275 Association between PPARγ Gene Polymorphism Haplotypes and Metabolic Syndrome in Chinese Population, Case-control and Family-based Study
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e4340 Baise city new characteristics of the different subtypes of hypertension illness diagnosis and the analysis of the relationship between metabolic syndrome
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e4322 Epicardial adipose tissue thickness in patients with metabolic syndrome: A Systematic Review and Meta-analysis
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e4282 Effect of Rosuvastatin on Atherosclerosis Plaque Biomechanics Patients with Metabolic Syndrome Using Multiple Tracking Techniques
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e3568 Cardiac Rehabilitation In Cardiac Patients with Metabolic Syndrome
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e3238 Effect of the combined increase of C-reactive protein and uric acid level on metabolic syndrome and its components
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e3216 Prevalence of Metabolic Syndrome among Iranian People Referring to Heart Centre
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e3117 Speckle Tracking Imaging in Assessment of the Carotid Artery Structure and Function in Subjects with Metabolic Syndrome
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e2305 Best predictor of metabolic syndrome by the predicting ability comparison of various anthropometric and atherogenic parameters among Kazakh population in Xinjiang
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e2295 Best single predictor of metabolic syndrome via comparing the predicting ability of various anthropometric and atherogenic parameters among Uighur population in Xinjiang
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e2149 Impact of metabolic syndrome on acute myocardial infarction in economic aspect
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e1413 Early detection of regional and global left ventricular myocardial function using strain and strain rate imaging evaluation longitudinal strain in patients with Metabolic syndrome
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e0873 Lipid-lowering therapy and lipid goal attainment in patients with metabolic syndrome in China: subgroup analysis of the Dyslipidemia International Study-China (DYSIS-China)
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

GW25-e0522 Relationship between job stress and metabolic syndrome in occupational population
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 13, 2014 Category: Radiology Source Type: research

Comparison of the effect of ‘metabolically healthy but obese’ and ‘metabolically abnormal but not obese’ phenotypes on development of diabetes and cardiovascular disease in Chinese
Abstract The present study was designed to determine the prevalence of ‘metabolically healthy but obese’ (MHO) and ‘metabolically abnormal but not obese’ (MANO) phenotypes in Chinese population, and to investigate the association of these two phenotypes with the risk of diabetes and cardiovascular disease (CVD). A total of 2,764 subjects aged 30–90 were followed up over a mean period of 43.80 ± 11.25 months. The metabolic syndrome was defined according to the joint committee for developing Chinese guidelines on prevention and treatment of dyslipidemia in adults. Subjects with body fat percentage (BF...
Source: Endocrine - October 13, 2014 Category: Endocrinology Source Type: research

Clinical aspects of urea transporters.
Abstract Jk antigens, which were identified as urea transporter B (UT-B) in the plasma membrane of erythrocytes, and which determine the Kidd blood type in humans, are involved in transfusion medicine, and even in organ transplantation. The Jk(a-b-) blood type is a consequence of a silent Slc14A1 gene caused by various mutations related to lineage. In addition, the specific mutations related to hypertension and metabolic syndrome cannot be ignored. Genome-wide association studies established Slc14A1 as a related gene of bladder cancer and some genotypes are associated with higher morbidity. This chapter aims to int...
Source: Sub-Cellular Biochemistry - October 13, 2014 Category: Biochemistry Authors: Ran J, Wang H, Hu T Tags: Subcell Biochem Source Type: research

Antioxidants and respiratory disease: the uric acid paradox
For humble individuals like myself, there is one poor comfort, which is this, viz. that gout, unlike any other disease, kills more rich men than poor, more wise men than simple. Thomas Sydenham. In clinical practice, high blood concentrations of uric acid (UA) are generally thought to be a bad thing—primarily because of the risk of gout, but also because individuals with high UA concentrations are at increased risk of cardiovascular disease, metabolic syndrome and hypertension1; these associations may reflect the fact that, under certain circumstances, UA can be pro-oxidant.2 Perhaps less appreciated are the potentia...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Shaheen, S. O. Tags: Editorial Source Type: research

Adverse Effects of Statins - Myths and Reality.
Abstract Statins reduce cardiovascular mortality and morbidity as well as cardiovascular events in patients with a very high risk of cardiovascular disease (CVD) and also in subjects with high or moderate risk by reducing the levels of low-density lipoprotein cholesterol (LDL-C). Although they are considered to be drugs with a very good safety profile, because of their wide use there are many concerns that their adverse effects might compromise their proven beneficial effects. Therefore this article reviews all the data and provides an evidence-based insight what are the proven adverse effects of statins and what a...
Source: Current Pharmaceutical Design - October 13, 2014 Category: Drugs & Pharmacology Authors: Simić I, Reiner Z Tags: Curr Pharm Des Source Type: research

Lifestyle counseling to reduce body weight and cardiometabolic risk factors among truck and bus drivers - a randomized controlled trial.
CONCLUSIONS: Weight reduction and decreases in cardiometabolic risk factors were clinically meaningful after 12 months of counseling. PMID: 25310464 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - October 13, 2014 Category: Occupational Health Authors: Puhkala J, Kukkonen-Harjula K, Mansikkamäki K, Aittasalo M, Hublin C, Kärmeniemi P, Olkkonen S, Partinen M, Sallinen M, Tokola K, Fogelholm M Tags: Scand J Work Environ Health Source Type: research

Long Chain Omega-3 Fatty Acids in Pediatric Metabolic Syndrome.
Abstract Concomitantly with the increasing prevalence of childhood obesity, the prevalence of metabolic syndrome (MetS) is rising among children and adolescents, leading to fears for future epidemics of type 2 diabetes mellitus and cardiovascular disease in the young. MetS includes central obesity, hypertension, low HDL cholesterol, high triglycerides, and elevated concentrations of fasting blood glucose. Nonalcoholic fatty liver disease (NAFLD), which is the most common cause of chronic liver disease both in adults and children, is currently considered as the hepatic component of MetS. Growing evidence suggests th...
Source: Mini Reviews in Medicinal Chemistry - October 13, 2014 Category: Chemistry Authors: Pacifico L, Giansanti S, Gallozzi A, Chiesa C Tags: Mini Rev Med Chem Source Type: research

IGF-1 and ADMA Levels Are Inversely Correlated in Nondiabetic Ankylosing Spondylitis Patients Undergoing Anti-TNF-Alpha Therapy.
In conclusion, in nondiabetic patients with AS undergoing periodic anti-TNF-α therapy, IGF-1 and ADMA are inversely correlated. PMID: 25295265 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 12, 2014 Category: Research Authors: Genre F, López-Mejías R, Rueda-Gotor J, Miranda-Filloy JA, Ubilla B, Villar-Bonet A, Carnero-López B, Gómez-Acebo I, Blanco R, Pina T, González-Juanatey C, Llorca J, González-Gay MA Tags: Biomed Res Int Source Type: research

Predictive value of serum apolipoprotein B/apolipoprotein A-I ratio in metabolic syndrome risk: a Chinese cohort study
Abstract The purpose of this study was to evaluate whether the apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio is a promising risk predictor of metabolic syndrome (MetS) and to determine the optimal cut-off value of this ratio in detecting subjects with MetS in a Chinese population. A prospective study was conducted using a representative sample of non-institutionized people in Taiwan. A total of 3,343 participants with mean age (±SD) of 39.86 (±15.61) years old were followed up from 2002 to 2007. The primary outcome was the incidence of MetS. The MetS was defined according to a unified criterion establi...
Source: Endocrine - October 12, 2014 Category: Endocrinology Source Type: research

Ezetimibe combined with standard diet and exercise therapy improves insulin resistance and atherosclerotic markers in patients with metabolic syndrome
ConclusionsEzetimibe combined with standard diet and exercise therapy improves not only body weight and atherogenic lipid profiles but also insulin resistance, blood pressure, and anthropometric factors in metabolic syndrome in a local‐dwelling Japanese. Interestingly, the improvement of insulin resistance had no correlation with that of other metabolic components.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 12, 2014 Category: Endocrinology Authors: Kyoko Ohbu‐Murayama, Hisashi Adachi, Yuji Hirai, Mika Enomoto, Ako Fukami, Aya Obuchi, Ayako Yoshimura, Sachiko Nakamura, Yume Nohara, Erika Nakao, Yoko Umeki, Yoshihiro Fukumoto Tags: Original Article Source Type: research

Optimal Management of HIV-HCV Coinfection
Abstract Around 25 % of HIV-positive individuals are HCV coinfected. HIV infection clearly worsened the natural history of chronic HCV infection, and despite the improved cares of comorbidities (chronic alcohol intake, metabolic syndrome, poor immune status by an earlier and better immune restoration with antiretrovirals (ARV), and finally by a decreasing hepatotoxicity of ARV), liver-related mortality remains one of the main causes of mortality in HIV/HCV-coinfected patients as compared to HIV monoinfected patients. Treatment options in HIV-HCV-coinfected patients have been greatly improved in the last few years...
Source: Current Hepatitis Reports - October 11, 2014 Category: Infectious Diseases Source Type: research

Effect of BMI on cardiovascular and metabolic syndrome risk factors in an Appalachian pediatric population.
CONCLUSION: The increased prevalence of overweight/obesity and the metabolic syndrome along with the increase in cardiovascular risk factors in Appalachian children and adolescents, suggests a cohort that may develop earlier onset and possibly increased severity of cardiovascular disease and other complications associated with metabolic syndrome and obesity. PMID: 25285020 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - October 11, 2014 Category: Endocrinology Authors: Weber KE, Fischl AF, Murray PJ, Conway BN Tags: Diabetes Metab Syndr Obes Source Type: research