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Effects of levothyroxine replacement therapy on parameters of metabolic syndrome and atherosclerosis in hypothyroid patients: a prospective pilot study.
This study included a group of 30 female patients with TSH level >4 mIU/L and 15 matched healthy controls. Intima media complex thickness (IMCT) and peak systolic flow velocity (PSFV) of superficial femoral artery were determined by Color Doppler scan. In hypothyroid subjects, BMI, SBP, DBP, and TSH were significantly increased versus controls and decreased after LT4 administration. FT4 was significantly lower in hypothyroid subjects compared with controls and significantly higher by treatment. TC, Tg, HDL-C, and LDL-C were similar to controls at baseline but TC and LDL-C were significantly decreased by LH4 treatment....
Source: International Journal of Endocrinology - March 31, 2015 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Estimation of First-Phase Insulin Secretion by Using Components of the Metabolic Syndrome in a Chinese Population.
Conclusions. Using MetS components, the FPIS could be estimated accurately. After adding FPI into the equation, the predictive power increased further. We hope that these equations could be widely used in daily practice. PMID: 25815010 [PubMed - as supplied by publisher] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 31, 2015 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Insulin resistance and impaired adipogenesis
Publication date: April 2015 Source:Trends in Endocrinology & Metabolism, Volume 26, Issue 4 Author(s): Birgit Gustafson , Shahram Hedjazifar , Silvia Gogg , Ann Hammarstedt , Ulf Smith The adipose tissue is crucial in regulating insulin sensitivity and risk for diabetes through its lipid storage capacity and thermogenic and endocrine functions. Subcutaneous adipose tissue (SAT) stores excess lipids through expansion of adipocytes (hypertrophic obesity) and/or recruitment of new precursor cells (hyperplastic obesity). Hypertrophic obesity in humans, a characteristic of genetic predisposition for diabetes, is asso...
Source: Trends in Endocrinology and Metabolism - March 31, 2015 Category: Endocrinology Source Type: research

Emerging cardiovascular indications of mineralocorticoid receptor antagonists
Publication date: April 2015 Source:Trends in Endocrinology & Metabolism, Volume 26, Issue 4 Author(s): Yasir Parviz , Javaid Iqbal , Bertram Pitt , David Adlam , Abdallah Al-Mohammad , Faiez Zannad Mineralocorticoid receptor (MR) antagonism is a well-established treatment modality for patients with hypertension, heart failure, and left ventricular systolic dysfunction (LVSD) post-myocardial infarction (MI). There are emerging data showing potential benefits of MR antagonists in other cardiovascular conditions. Studies have shown association between MR activation and the development of myocardial fibrosis, corona...
Source: Trends in Endocrinology and Metabolism - March 31, 2015 Category: Endocrinology Source Type: research

Notch signaling as a novel regulator of metabolism
Publication date: Available online 21 March 2015 Source:Trends in Endocrinology & Metabolism Author(s): Pengpeng Bi , Shihuan Kuang Evolutionarily unprepared for modern high-calorie diets and sedentary lifestyles, humans are now unprecedentedly susceptible to metabolic disorders such as obesity, type 2 diabetes (T2D), nonalcoholic fatty liver, and cardiovascular disease. These metabolic conditions are intertwined, together known as metabolic syndrome, and compromise human life quality as well as lives. Notch signaling, a fundamental signal transduction pathway critical for cell–cell communication and developmen...
Source: Trends in Endocrinology and Metabolism - March 31, 2015 Category: Endocrinology Source Type: research

Impact of Metabolic Syndrome on the Hospitalization Rate of Crohn's Disease Patients Seen at a Tertiary Care Center: A Retrospective Cohort Study
Conclusions: CD patients with MetS have a higher rate of CD-related hospitalization compared to those without MetS. Hypertriglyceridemia, low HDL cholesterol and DM may be good markers of local and systemic inflammation as seen in CD.Digestion 2015;91:257-262 (Source: Digestion)
Source: Digestion - March 30, 2015 Category: Gastroenterology Source Type: research

Relationship of Leptin with adiposity and inflammation and Resistin with disease severity in Psoriatic patients undergoing anti‐TNF‐alpha therapy
ConclusionIn patients with moderate‐to‐severe psoriasis leptin correlates with metabolic syndrome features and inflammation whereas resistin correlate with inflammation and disease severity. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - March 30, 2015 Category: Dermatology Authors: T. Pina, F. Genre, R. Lopez‐Mejias, S. Armesto, B. Ubilla, V. Mijares, T. Dierssen‐Sotos, M.A. Gonzalez‐Lopez, M.C. Gonzalez‐Vela, R. Blanco, J.L. Hernández, J. Llorca, M.A. Gonzalez‐Gay Tags: Original Article Source Type: research

Self-management training for Chinese obese children at risk for metabolic syndrome: Effectiveness and implications for school health
This article reviews the results of a school-based self-management intervention for Chinese obese children at risk for metabolic syndrome. Twenty-eight Chinese obese children (M age = 10 years) and their parents participated in the study. Metabolic syndrome risk factors were measured pre- and post-intervention. The risk factors included Body Mass Index, waist circumstance, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, High-sensitivity C-reactive Protein, fasting plasma glucose, and fasting blood insulin. After 6 months of school-...
Source: School Psychology International - March 30, 2015 Category: Psychiatry & Psychology Authors: Ling, J., Anderson, L. M., Ji, H. Tags: Articles Source Type: research

Circadian regulators of intestinal lipid absorption [Thematic Reviews]
Among all the metabolites present in the plasma, lipids, mainly triacylglycerol and diacylglycerol, show extensive circadian rhythms. These lipids are transported in the plasma as part of lipoproteins. Lipoproteins are synthesized primarily in the liver and intestine and their production exhibits circadian rhythmicity. Studies have shown that various proteins involved in lipid absorption and lipoprotein biosynthesis show circadian expression. Further, intestinal epithelial cells express circadian clock genes and these genes might control circadian expression of different proteins involved in intestinal lipid absorption. In...
Source: The Journal of Lipid Research - March 30, 2015 Category: Lipidology Authors: Hussain, M. M., Pan, X. Tags: Thematic Reviews Source Type: research

Ileal Food Diversion: a Simple, Powerful and Easily Revisable and Reversible Single-Anastomosis Gastric Bypass
Conclusions Ileal food diversion is an interesting option in super-obese patients, re-do surgery and patients with metabolic syndrome. Technical considerations, physiological assumptions and rationale were discussed. (Source: Obesity Surgery)
Source: Obesity Surgery - March 28, 2015 Category: Surgery Source Type: research

Inverse association between central obesity and arterial stiffness in Korean subjects with metabolic syndrome: a cross-sectional cohort study.
CONCLUSIONS: Despite the significant correlation between the number of MetS components and arterial stiffness, there appeared to be an inverse association between CeO and arterial stiffness in MetS subjects. In contrast to the IDF definition, our findings suggest that CeO is not crucial for the diagnosis of MetS in otherwise healthy Koreans having multiple metabolic risk factors with respect to subclinical atherosclerosis reflected in arterial stiffness. PMID: 25810782 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - March 28, 2015 Category: Endocrinology Authors: Won KB, Chang HJ, Niinuma H, Niwa K, Jeon K, Cho IJ, Shim CY, Hong GR, Chung N Tags: Diabetol Metab Syndr Source Type: research

Oxidative DNA damage in diabetic and mild gestational hyperglycemic pregnant women.
CONCLUSION: Gestational, overt diabetes and mild gestational hyperglycemia, were all related to increased oxidative DNA damage. Diabetic pregnant women showed increased level of oxidative DNA damage, perhaps mainly due to hyperglycemia. On the other hand, oxidative DNA damage detected in women with mild gestational hyperglycemia might be associated with repercussions from obesity, hypertension and/or insulin resistance. Interestingly, the type of DNA base affected seemed to be dependent on the glycemic profile or oxidative stress. PMID: 25810781 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - March 28, 2015 Category: Endocrinology Authors: Gelaleti RB, Damasceno DC, Lima PH, Salvadori DM, Calderon Ide M, Peraçoli JC, Rudge MV Tags: Diabetol Metab Syndr Source Type: research

Targeting AMPK for cancer prevention and treatment.
Authors: Li W, Saud SM, Young MR, Chen G, Hua B Abstract AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated, AMPK can promote ATP production and regulate metabolic energy. AMPK is a known target for treating metabolic syndrome and type-2 diabetes; however, recently AMPK is emerging as a possible metabolic tumor suppressor and target for cancer prevention and treatment. Recent epidemiological studies indicate that treatment with metformin, an AMPK activator reduces the incidence of cancer. In t...
Source: Oncotarget - March 28, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Microvascular reactivity in women with gestational diabetes mellitus studied during pregnancy
Conclusion: Attenuated microvascular reactivity as an early marker of endothelial dysfunction is not present in women with GDM when assessed during pregnancy. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - March 28, 2015 Category: Endocrinology Authors: Isabelle PontesKarine AfraJosé SilvaPaulo BorgesGeraldine CloughJoão Alves Source Type: research

Pilot study on the effects of a 2-week hiking vacation at moderate versus low altitude on plasma parameters of carbohydrate and lipid metabolism in patients with metabolic syndrome
Background: Hypoxic and hypobaric conditions may augment the beneficial influence of training on cardiovascular risk factors. This pilot study aimed to explore for effects of a two-week hiking vacation at moderate versus low altitude on adipokines and parameters of carbohydrate and lipid metabolism in patients with metabolic syndrome. Methods: Fourteen subjects (mean age: 55.8 years, range: 39 – 69) with metabolic syndrome participated in a 2-week structured training program (3 hours of guided daily hiking 4 times a week, training intensity at 55-65% of individual maximal heart rate; total training time, 24 hours). Pa...
Source: BMC Research Notes - March 28, 2015 Category: Research Authors: Ivana GutwengerGeorg HoferAnja GutwengerMarco SandriChristian Wiedermann Source Type: research

Liver and Other Gastrointestinal Cancers Are Frequent in Mexican Americans
Conclusions Gastrointestinal system cancers, particularly, liver cancer, in a Mexican American health disparity cohort and their relatives rank higher than in other ethnicities and are associated with high rates of diabetes and metabolic syndrome. Effective prevention of diabetes and low-tech, high-quality screening strategies for gastrointestinal cancers are needed in health disparity communities. (Source: Journal of Racial and Ethnic Health Disparities)
Source: Journal of Racial and Ethnic Health Disparities - March 28, 2015 Category: Global & Universal Source Type: research

Nonalcoholic fatty liver disease is associated with coronary artery calcium score in diabetes patients with higher HbA1c
Background: In patients with diabetes, studies investigating the association between nonalcoholic fatty liver disease (NAFLD) and coronary artery calcium score (CACS) have shown conflicting results. The aim of this study was to evaluate the association between NAFLD and CACS in diabetic patients. Methods: This is the cohort study performed in Seoul National University Hospital Gangnam Healthcare Center. NAFLD was defined as cases with the typical ultrasonographic findings without excessive alcohol consumption, medications causing hepatic steatosis or other chronic liver diseases. CACS was evaluated using the Agatston metho...
Source: Diabetology and Metabolic Syndrome - March 28, 2015 Category: Endocrinology Authors: Min-Sun KwakJeong YimDonghee KimMin ParkSeon LimJong YangGoh ChungYoung KimSun YangMi KimChang-Hoon LeeJung-Hwan YoonHyo-Suk Lee Source Type: research

Brain inflammation and psoriasis: a [11C]‐(R)‐PK11195 positron emission tomography study
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - March 27, 2015 Category: Dermatology Authors: H.J.A. Hunter, R. Hinz, A. Gerhard, P.S. Talbot, Z. Su, G. Holland, S.J. Hopkins, C.E.M. Griffiths, C.E. Kleyn Tags: Research Letter Source Type: research

The prevalence of metabolic syndrome in South Asia: a systematic review
The objective of this study was to estimate the prevalence of metabolic syndrome and its individual components in South Asia region. A search was conducted on PubMed, Scopus and OvidSP (MedLine and EMBASE) using the term ‘metabolic syndrome’, ‘prevalence’ and the name of each South Asian country for studies published on or after the year 2000. Reference lists and citation references of the included papers were also checked. Eligibility criteria were mainly population-based studies on both gender and healthy participants aged ≥18 years. Four definitions of metabolic syndrome were considered: the World Health Orga...
Source: International Journal of Diabetes in Developing Countries - March 27, 2015 Category: Endocrinology Source Type: research

Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis
Publication date: Available online 25 March 2015 Source:Molecular and Cellular Endocrinology Author(s): Vassilios Papadopoulos , Yasaman Aghazadeh , Jinjiang Fan , Enrico Campioli , Barry Zirkin , Andrew Midzak Steroidogenesis begins with cholesterol transfer into mitochondria through the transduceosome, a complex composed of cytosolic proteins that include steroidogenesis acute regulatory protein (STAR), 14-3-3 adaptor proteins, and the outer mitochondrial membrane proteins Translocator Protein (TSPO) and Voltage-Dependent Anion Channel (VDAC). TSPO is a drug- and cholesterol- binding protein found at particularly high ...
Source: Molecular and Cellular Endocrinology - March 27, 2015 Category: Endocrinology Source Type: research

Angiopoietin-2 as a biomarker for metabolic syndrome and disease activity in rheumatoid arthritis patients
Conclusions Angiopoietin-2 can be used as a biomarker of MetS and disease activity in RA patients. This could point to those RA patients at risk of developing CVDs. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - March 27, 2015 Category: Rheumatology Source Type: research

The prevention and treatment of hypoadiponectinemia-associated human diseases by up-regulation of plasma adiponectin
Publication date: Available online 26 March 2015 Source:Life Sciences Author(s): Murad Hossain , Abdul Mukheem , Tunku Kamarul Hypoadiponectinemia is characterized by low plasma adiponectin levels that can be caused by genetic factors, such as single nucleotide polymorphisms (SNPs) and mutations in the adiponectin gene or by visceral fat deposition/obesity. Reports have suggested that hypoadiponectinemia is associated with dyslipidemia, hypertension, hyperuricemia, metabolic syndrome, atherosclerosis, type 2 diabetes mellitus and various cardiovascular diseases. Previous studies have highlighted several potential strateg...
Source: Life Sciences - March 27, 2015 Category: Biology Source Type: research

Non-alcoholic Fatty Liver Disease and Metabolic Syndrome—Position Paper of the Indian National Association for the Study of the Liver, Endocrine Society of India, Indian College of Cardiology and Indian Society of Gastroenterology
Publication date: Available online 6 March 2015 Source:Journal of Clinical and Experimental Hepatology Author(s): Ajay Duseja , Shivaram P. Singh , Vivek A. Saraswat , Subrat K. Acharya , Yogesh K. Chawla , Subhankar Chowdhury , Radha K. Dhiman , Rohinivilasam V. Jayakumar , Kaushal Madan , Sri P. Misra , Hrudananda Mishra , Sunil K. Modi , Arumugam Muruganathan , Banshi Saboo , Rakesh Sahay , Rajesh Upadhyay Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic syndrome. Prevalence of metabolic risk factors including diabetes mellitus, obesity, etc. is rapidly increasing in India putting this po...
Source: Journal of Clinical and Experimental Hepatology - March 27, 2015 Category: Gastroenterology Source Type: research

Prevalence of metabolic syndrome among Roma: a comparative health examination survey in Hungary
Conclusions: Besides tackling the socio-economic determinants of the poor health of Roma people, specific public health interventions considering increased genetic susceptibility to metabolic disturbances are needed to improve their health status. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 27, 2015 Category: Journals (General) Authors: Kosa, Z., Moravcsik-Kornyicki, A., Dioszegi, J., Roberts, B., Szabo, Z., Sandor, J., Adany, R. Tags: Socioeconomic conditions Source Type: research

Metabolic syndrome showed significant relationship with carotid atherosclerosis
Abstract Metabolic syndrome (MetS) is associated with an increased risk of cardiovascular disease. We assessed the associations between MetS and the indicators of carotid atherosclerosis as assessed by ultrasonography taking into consideration of confounders in the general population. A total of 1281 subjects (856 males, 425 females) were included in the present study. The total plaque score and maximum intima-media thickness (IMT) of the carotid arteries were measured as indicators of atherosclerosis. Cardiovascular risk factors were several metabolic components, serum uric acid, serum C-reactive protein (CRP...
Source: Heart and Vessels - March 26, 2015 Category: Cardiology Source Type: research

Retraction Note: Leisure-time physical activity and the risk of metabolic syndrome: meta-analysis
(Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 26, 2015 Category: Research Source Type: research

(−)-Epicatechin reduces blood pressure increase in high fructose-fed rats: effects on the determinants of nitric oxide bioavailability
This work investigated the blood pressure (BP) lowering effect of the flavanol (−)-epicatechin in a model of metabolic syndrome. Rats were fed a regular chow diet without (Control) or with 10% (w/v) fructose in the drinking water (high fructose, HF) for 8 w. A subgroup of the HF-fed rats was supplemented with (−)-epicatechin 20 mg/kg body weight (HF-EC). Dietary (−)-epicatechin reverted the increase in BP caused by the fructose treatment. In aorta, superoxide anion production and the expression of the NADPH oxidase (NOX) subunits p47phox and p22phox were enhanced in the HF-fed rats. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 26, 2015 Category: Biochemistry Authors: Maria C. Litterio, Marcela A. Vazquez-Prieto, Ana M. Adamo, Rosana Elesgaray, Patricia I. Oteiza, Monica Galleano, Cesar G. Fraga Source Type: research

Increased physical activity may be more protective for metabolic syndrome than reduced caloric intake. An analysis of estimated energy balance in U.S. adults: 2007-2010 NHANES
The purpose of this study was to examine the association between physical activity (PA), caloric intake.and Metabolic Syndrome (MetS) in a representative sample of the United States population. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 25, 2015 Category: Nutrition Authors: Andrew D. Frugé, Sylvia H. Byrd, Brent J. Fountain, Jeralynn S. Cossman, M.Wes Schilling, Patrick Gerard Source Type: research

Prevalence of metabolic syndrome in rural elderly of Asian Indian origin
ConclusionIt seems reasonable to argue that MS is considerably high in the rural elderly of Asian Indian origin and early intervention is warranted to avoid further escalation in cardiovascular disease. Am. J. Hum. Biol., 2015. © 2015 Wiley Periodicals, Inc. (Source: American Journal of Human Biology)
Source: American Journal of Human Biology - March 25, 2015 Category: Biology Authors: Tanmay Nag, Arnab Ghosh Tags: Short Report Source Type: research

Associations Between Physical Activity and Metabolic Syndrome: Comparison Between Self-Report and Accelerometry.
Conclusion . Individuals who do not meet the PA guidelines exhibited greater odds of having metabolic syndrome. This relationship tended to be stronger for objective PA measures than for self-report. PMID: 25806568 [PubMed - as supplied by publisher] (Source: American Journal of Health Promotion : AJHP)
Source: American Journal of Health Promotion : AJHP - March 25, 2015 Category: Global & Universal Authors: Tucker JM, Welk GJ, Beyler NK, Kim Y Tags: Am J Health Promot Source Type: research

Assessment of Cardiovascular Risk in Adults With Type 2 Diabetes and Metabolic Syndrome: Framingham Versus UKPDS Equations
Conclusions About one-fourth of adults with T2DM and metabolic syndrome had high level of CVD risk (>20%). In practice, people with diabetes and metabolic syndrome could be managed earlier and more intensively based on their risk estimated by the Framingham or UKPDS equations. (Source: The Diabetes Educator)
Source: The Diabetes Educator - March 25, 2015 Category: Endocrinology Authors: Kim, C.-J., Kang, H. S., Schlenk, E. A., Chae, S.-M. Tags: Features Source Type: research

Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance
Conclusions: Gender differences in the relationship between betatrophin and irisin indicate that there might be cytokine-mediated crosstalk among the liver, adipose tissue and skeletal muscle. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - March 25, 2015 Category: Endocrinology Authors: Xinmiao XieTing GaoMeili YangPeihong ChenHua JinLili YangXuemei Yu Source Type: research

A randomised controlled trial of a physical activity and nutrition program targeting middle-aged adults at risk of metabolic syndrome in a disadvantaged rural community
This study aims to determine if a low-cost, accessible lifestyle program targeting insufficiently active adults aged 50-69 y can be successfully implemented in a rural location, and whether its implementation will contribute to the reduction / prevention of metabolic syndrome, or other risk factors for type 2 diabetes, and cardiovascular disease.Methods/DesignThis 6-month randomised controlled trial will consist of a nutrition, physical activity, and healthy weight intervention for 50–69 year-olds from a disadvantaged rural community. Five hundred participants with central obesity and at risk of metabolic syndrome will b...
Source: BMC Public Health - March 25, 2015 Category: Consumer Health News Authors: Krysten BlackfordJonine JanceyAndy LeeAnthony JamesPeter HowatAndrew HillsAnnie Anderson Source Type: research

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, heart and lung diseases, cancer, osteoporosis, arthritis, and dementia. The heterogeneity in biological aging, chronological age, and aging-associated disorders in humans have been ascribed to different genetic and environmental factors (i.e., diet, pollution, stress) that are closely linked to socioeconomic factors. The common denominator of these factors is the inflammatory response. Chronic low-grade systemic inflammat...
Source: Clinical Epigenetics - March 25, 2015 Category: Research Authors: Katarzyna vel SzicKen DeclerckMelita Vidakovi¿Wim Vanden Berghe Source Type: research

Associations of intergenerational education with metabolic health in US Latinos.
CONCLUSIONS: Intergenerational exposure to low education levels may increase central obesity and type 2 diabetes differentially among US-born and foreign-born Latinos. PMID: 25809593 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - March 25, 2015 Category: Eating Disorders and Weight Management Authors: Zeki Al Hazzouri A, Haan MN, Robinson WR, Gordon-Larsen P, Garcia L, Clayton E, Aiello AE Tags: Obesity (Silver Spring) Source Type: research

Association between metabolic syndrome and pelvic organ prolapse severity
Conclusions The diagnosis of MS and the presence of elevated triglycerides may be associated with the severity of POP in urogynecological patients. Longitudinal studies are required to assess whether the MS risk factors might predict the progression of POP and whether elimination of the risk factors might improve the prognosis in POP patients. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - March 24, 2015 Category: OBGYN Source Type: research

The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms
Modern lifestyle has profoundly modified human sleep habits. Sleep duration has shortened over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally, irregular sleep, shift work and travelling across time zones lead to disruption of circadian rhythms and asynchrony between the master hypothalamic clock and pacemakers in peripheral tissues. Furthermore, obstructive sleep apnea syndrome (OSA), which affects 4 - 15% of the population, is not only characterized by impaired sleep architecture but also by repetitive hemoglobin desaturations during sleep. Epidemiological studies have identified ...
Source: Diabetology and Metabolic Syndrome - March 24, 2015 Category: Endocrinology Authors: Anne Briançon-MarjolletMartin WeiszensteinMarion HenriAmandine ThomasDiane Godin-RibuotJan Polak Source Type: research

Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study
Conclusion: VFO, measured using BIA, is observed more frequently in patients with primary gout compared with healthy controls, even in non-obese individuals. Therefore, VFO might more properly represent metabolic derangements in patients with gout than general obesity. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 24, 2015 Category: Rheumatology Authors: Jennifer LeeJi-Yeon LeeJae-Ho LeeSeung-Min JungYoung SuhJung-Hee KohSeung-Ki KwokJi JuKyung-Su ParkSung-Hwan Park Source Type: research

Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6,607 non-diabetic Finnish men
We investigated the association of various lipoprotein traits, apolipoproteins and their ratios with the deterioration of glycemia, incident type 2 diabetes, insulin resistance and insulin secretion in a large population-based Metabolic Syndrome in non-diabetic Men (METSIM) Study.Research design and methods The METSIM Study includes 10,197 Finnish men, aged 45-73 years, and examined in 2005-2010. From 6,607 non-diabetic participants without statin treatment at baseline, 386 developed incident type 2 diabetes during a 5.9-year follow-up. (Source: Atherosclerosis)
Source: Atherosclerosis - March 24, 2015 Category: Cardiology Authors: Mária Fízeľová, Manna Miilunpohja, Antti J. Kangas, Pasi Soininen, Johanna Kuusisto, Mika Ala-Korpela, Markku Laakso, Alena Stančáková Source Type: research

Insulin sensitivity improvement of fermented Korean Red Ginseng (Panax ginseng) mediated by insulin resistance hallmarks in old aged ob/ob mice
Conclusion These results suggest that FRG may play a vital role in improving insulin sensitivity relative to reducing of body weight in old aged ob/ob mice. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 24, 2015 Category: Complementary Medicine Source Type: research

Maternal smoking dysregulates protein expression in second trimester human fetal livers in a sex-specific manner.
CONCLUSIONS: The fetal liver exhibits marked sex differences at the protein level, and these are disturbed by maternal smoking. The foundations for smoke-induced post-natal diseases are likely to be due to sex-specific effects on diverse pathways. PMID: 25803269 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 24, 2015 Category: Endocrinology Authors: Filis P, Nagrath N, Fraser M, Hay DC, Iredale JP, O'Shaughnessy P, Fowler PA Tags: J Clin Endocrinol Metab Source Type: research

Suppression of the Pregnane X Receptor during Endoplasmic Reticulum Stress Is Achieved by Down-Regulating Hepatocyte Nuclear Factor-4{alpha} and Up-Regulating Liver-Enriched Inhibitory Protein
This study was performed to determine whether ER stress condition decreases the expression of PXR and whether the decrease alters the induction of cytochrome P450 3A4 (CYP3A4). Human primary hepatocytes and HepG2 cell line (human hepatocellular carcinoma) were treated with brefeldin A and thapsigargin, 2 well-established ER stressors. Without exceptions, both stressors significantly decreased the expression of PXR. The decrease led to reduced induction of CYP3A4. Reporter dissection study, electrophoretic mobility shift assay, and chromatin immunoprecipitation located in the PXR promoter region 2 adjacent elements recogniz...
Source: Toxicological Sciences - March 24, 2015 Category: Toxicology Authors: Vachirayonsti, T., Ho, K. W., Yang, D., Yan, B. Tags: Regulation of Pregnane X Receptor During ER Stress Source Type: research

Angiotensin II Induces Interleukin-1{beta}-Mediated Islet Inflammation and {beta}-Cell Dysfunction Independently of Vasoconstrictive Effects
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin secretion. However, the direct effects of angiotensin II on islet function and underlying mechanisms independent of changes in blood pressure remain unclear. Here we show that exposure of human and mouse islets to angiotensin II induces interleukin (IL)-1–dependent expression of IL-6 and MCP-1, enhances β-cell apoptosis, and impairs mitochondrial function and insul...
Source: Diabetes - March 24, 2015 Category: Endocrinology Authors: Sauter, N. S.; Thienel, C.; Plutino, Y.; Kampe, K.; Dror, E.; Traub, S.; Timper, K.; Bedat, B.; Pattou, F.; Kerr-Conte, J.; Jehle, A. W.; Boni-Schnetzler, M.; Donath, M. Y. Tags: Islet Studies Source Type: research

High-risk alcohol use and anxiety and depression symptoms in adolescents and adults with type 1 diabetes mellitus: a cross-sectional study
Conclusions: The frequency of high-risk drinking increased along with age and was greater among males; however, this frequency did not exhibit differences in terms of gender among adolescents. There was a positive association between high risk alcohol consumption and anxiety and depression symptoms, although glycemic control was inadequate in most of the sample independent of alcohol consumption and the presence of anxiety and depression symptoms. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - March 24, 2015 Category: Endocrinology Authors: Maria KnychalaMaria JorgeCinara MunizPriscila FariaPaulo Jorge Source Type: research

Reactive Oxygen Species Response to Exercise Training and Weight Loss in Sedentary Overweight and Obese Female Adults.
CONCLUSIONS: A 12-week program of nutritional and exercise intervention in overweight/obese sedentary women improves levels of oxidative stress when accompanied by weight loss and improved fitness. More than restricted caloric intake, physical activity at a relatively high intensity was effective in improving cardiovascular risk markers. The reduction in ROS may be an additional mechanism by which physical activity may contribute to preventing metabolic syndrome and subsequent atherosclerotic disease. PMID: 25806958 [PubMed - as supplied by publisher] (Source: Journal of Cardiopulmonary Rehabilitation and Prevention)
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - March 24, 2015 Category: Rehabilitation Authors: Bianchi VE, Ribisl PM Tags: J Cardiopulm Rehabil Prev Source Type: research

Eprosartan in Canadian hypertensives with diabetes
Petrella RJ, Gill DP, Berrou JP (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - March 23, 2015 Category: Endocrinology Source Type: research

Persistence of Cardiovascular Risk Factors in Women With Previous Preeclampsia: A Long-term Follow-up Study
Conclusions: Preeclampsia might be a risk factor for the development of cardiovascular risk factors at least 5 years after index pregnancy. Serum uric acid and microalbuminuria may be mechanistic mediators of heightened risk, along with impaired endothelial function in preeclampsia. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - March 23, 2015 Category: Research Tags: Original Articles Source Type: research

[waist-height ratio and risk of metabolic syndrome in chilean adolescent].
CONCLUSION: It has been calculated the risk of MS for Chilean adolescents using WHR and it is associated to sex and region. Additionally percentile tables of WHR for Chilean adolescents aged 13 to 16 have been calculated. PMID: 25795945 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - March 23, 2015 Category: Nutrition Authors: Garcia-Rubio J, Lopez-Legarrea P, Gomez-Campos R, Cossio-Bolaños M, Merellano-Navarro E, Olivares PR Tags: Nutr Hosp Source Type: research

[prevalence of metabolic syndrome and associated risk factors in ecuadorian university students].
CONCLUSION: In the tested sample was found that 1 out of 13 students had MS and 1 out of 2 had at least one risk factor for MS. According with the pre-obesity and obesity result, 1 out of 4 students shows one of these symptoms. In addition, these results show the direct relationship between risk factors and TA. Finally, Healthy lifestyles promotion (includes non-pharmacological treatments such diet and exercise) could be the first goal to prevent metabolic disease, because the large amount of persons with at least one risk factor for MS. PMID: 25795943 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - March 23, 2015 Category: Nutrition Authors: Ruano Nieto CI, Melo Pérez JD, Mogrovejo Freire L, De Paula Morales KR, Espinoza Romero CV Tags: Nutr Hosp Source Type: research

Cut-off values of waist circumference to predict metabolic syndrome in obese adolescents.
CONCLUSION: MetS group presented significant higher metabolic alterations and inflammation compared to Non-MetS group. Waist circumference is considered an anthropometric measure predictor of metabolic syndrome in obese adolescents, being useful in clinical practice. PMID: 25795939 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - March 23, 2015 Category: Nutrition Authors: Cristina Landi Masquio D, De Piano Ganen A, Munhoz da Silveira Campos R, De Lima Sanches P, Campos Corgosinho F, Caranti D, Tock L, De Mello MT, Tufik S, Dâmaso AR Tags: Nutr Hosp Source Type: research