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Metabolic Syndrome

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A periconceptional maternal hyperglycemia disrupts the feto-placental membrane fatty acid profiles in a rabbit model
Type-1 diabetes (T1D) is caused by the reduction in pancreatic insulin secretion, inducing chronic hyperglycemia. Pre-gestational T1D increases the risk of miscarriage and congenital malformations and programs the offspring to develop metabolic syndrome at adulthood. Management of maternal diabetes is essential during the gestation but could be highly important around the conception. (Source: Placenta)
Source: Placenta - August 29, 2014 Category: Reproduction Medicine Authors: Delphine Rousseau-Ralliard, Emilie Derisoud, Anne Tarrade, Roselyne Brat, Audrey Rolland, Rene Thieme, Anne Navarette-Santos, Bernd Fischer, Pascale Chavatte-Palmer Tags: Frontmatter Source Type: research

Impact of metabolic syndrome traits on cardiovascular function: should the Adult Treatment Panel III definition be further stratified?
AimsThe aims of the study were to evaluate whether a further classification of metabolic syndrome according to the number of traits (based on the Adult Treatment Panel III definition) could better explain the impact on cardiovascular remodeling and function, and to assess the role of single metabolic syndrome components in this regard. MethodsWe studied by echocardiography and carotid ultrasound 435 asymptomatic patients with metabolic syndrome. Patients with coronary artery disease or more than mild valvular heart disease were excluded. Carotid stiffness index (β) was measured using a high-resolution echo-tracking system...
Source: Journal of Cardiovascular Medicine - August 28, 2014 Category: Cardiology Tags: Obesity and the metabolic syndrome: Original articles Source Type: research

Are there mild and serious metabolic syndromes? The need for a graded diagnosis
Metabolic syndrome is an increasingly incident complex metabolic disorder, affecting around 30% of adults in the USA as well as in Europe. In a meta-analysis that evaluated cardiovascular risk associated with the third National Cholesterol Education Program definition of metabolic syndrome in 951 083 patients, metabolic syndrome was associated with a two-fold increase in the risk of coronary heart disease, cerebrovascular disease, all cardiovascular lethal and nonlethal cardiovascular diseases, and a 1.5-fold increase in the risk of all-cause mortality.In this context, the article in this issue of the Journal of Cardiova...
Source: Journal of Cardiovascular Medicine - August 28, 2014 Category: Cardiology Tags: Obesity and the metabolic syndrome: Editorial comment Source Type: research

Index of central obesity as a parameter to replace waist circumference for the definition of metabolic syndrome in predicting cardiovascular disease
ConclusionICO was a better predictor of abnormal triglyceride and high-density lipoprotein levels than waist circumference, but waist circumference was a better predictor of hyperglycemia and hypertension than ICO. However, we failed to support ICO as a better parameter for metabolic syndrome definition in predicting CVD risk compared with waist circumference. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 28, 2014 Category: Cardiology Tags: Obesity and the metabolic syndrome: Original articles Source Type: research

The impact of the metabolic syndrome on the outcome after aortic valve replacement
ConclusionThe metabolic syndrome does not change severity of the aortic stenosis, but significantly impacts the left ventricular remodeling in these patients. The metabolic syndrome and left ventricular hypertrophy, irrespective of hypertension and diabetes, are predictors of the short-term and mid-term outcome of patients with aortic stenosis who underwent aortic valve replacement. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 28, 2014 Category: Cardiology Tags: Obesity and the metabolic syndrome: Original articles Source Type: research

Effects of bariatric surgery on right ventricular structure and function
ConclusionThe present review shows that bariatric surgery exerts beneficial effects on RV structure and function in morbidly obese patients. As RV changes are independent predictors of outcomes, improvement of RV structure and function may contribute to the cardioprotective effects of bariatric surgery. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 28, 2014 Category: Cardiology Tags: Obesity and the metabolic syndrome: Review Source Type: research

Racial/Ethnic Disparities in Monitoring Metabolic Parameters for Patients with Schizophrenia Receiving Antipsychotic Medications.
CONCLUSION: Guideline-concordant monitoring metabolic parameters appear to be equitable but low and somewhat at odds with racial/ethnic risk among older patients with schizophrenia. Physicians should discuss lipids, weight, and glucose with patients at risk for developing heart disease, diabetes, and other sequelae of the metabolic syndrome. PMID: 25154537 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - August 28, 2014 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Heterogeneous Vascular Responses to Lifestyle Intervention in Obese Latino Adolescents
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - August 28, 2014 Category: Endocrinology Tags: article Source Type: research

Increased Adipose Tissue Insulin Resistance in Metabolic Syndrome: Relationship to Circulating Adipokines
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - August 27, 2014 Category: Endocrinology Tags: article Source Type: research

Endotoxemia of Metabolic Syndrome: A Pivotal Mediator of Meta-Inflammation
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - August 27, 2014 Category: Endocrinology Tags: article Source Type: research

Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - August 27, 2014 Category: Nutrition Authors: Michael Habermeyer, Angelika Roth, Sabine Guth, Patrick Diel, Karl‐Heinz Engel, Bernd Epe, Peter Fürst, Volker Heinz, Hans‐Ulrich Humpf, Hans‐Georg Joost, Dietrich Knorr, Theo Kok, Sabine Kulling, Alfonso Lampen, Doris Marko, Gerhard Rechkemmer, Iv Tags: Review Source Type: research

Gender differences in associations of serum ferritin and diabetes, metabolic syndrome, and obesity in China Health and Nutrition Survey
ConclusionsThere was a gender difference in associations between ferritin and MetS, obesity, and diabetes in Chinese. Further evaluations of the variation in gender on these associations are warranted to understand the mechanisms behind gender differences.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - August 27, 2014 Category: Nutrition Authors: Ling‐ling Han, Yu‐xia Wang, Jia Li, Xiao‐lei Zhang, Che Bian, He Wang, Shufa Du, Lin‐na Suo Tags: Research Article Source Type: research

A Low-Frequency Variant in MAPK14 Provides Mechanistic Evidence of a Link With Myeloperoxidase: A Prognostic Cardiovascular Risk Marker [Genetics]
Conclusions As myeloperoxidase is a prognostic marker of coronary events, the MAPK14 variant may provide a mechanistic link between p38 map kinase and these events, providing information consistent with current indication of Losmapimod for acute coronary syndrome. If replicated, the association with glomerular filtration rate, along with previous biological findings, also provides support for kidney diseases as alternative indications. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - August 27, 2014 Category: Cardiology Authors: Waterworth, D. M., Li, L., Scott, R., Warren, L., Gillson, C., Aponte, J., Sarov-Blat, L., Sprecher, D., Dupuis, J., Reiner, A., Psaty, B. M., Tracy, R. P., Lin, H., McPherson, R., Chissoe, S., Wareham, N., Ehm, M. G. Tags: Genetics Source Type: research

An update on the prevalence of metabolic syndrome and its associated factors in rural northeast china
Conclusion: The prevalence of MetS was high in the rural areas of China, especially among females. In addition to some of the more conventional risk factors associated with MetS, including age, sex, annual income and educational status, we also found that having more than one child and frequent consumption of tea and beans were risk factors for MetS, while smoking was a common factor among those that did not have MetS in rural Northeast China. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - August 26, 2014 Category: Consumer Health News Authors: Shasha YuXiaofan GuoHongmei YangLiqiang ZhengYingxian Sun Source Type: research

Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content.
Conclusions/Interpretation: We demonstrate that relatively short-term isoenergetic changes in the diet significantly alter the relation of AA-signatures with IR, with possible implications on the determination and treatment of diabetes risk. Trial registration: Clinicaltrials.gov as NCT00579657. PMID: 25157543 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 26, 2014 Category: Endocrinology Authors: Hattersley JG, Pfeiffer AF, Roden M, Petzke KJ, Hoffmann D, Rudovich NN, Randeva HS, Vatish M, Osterhoff M, Goegebakan O, Hornemann S, Nowotny P, Machann J, Hierholzer J, von Loeffelholz C, Möhlig M, Arafat AM, Weickert MO Tags: J Clin Endocrinol Metab Source Type: research

Using Basic and Clinical Research in Cardiology to Achieve Personalized Medicine Is it a Maze or Math?
Personalized medicine will be integral in further driving down the global impact of cardiovascular disease. Basic and clinical research in cardiovascular medicine has rapidly progressed over the last several decades, causing decreases in mortality and morbidity. Longevity is a positive consequence of the battle against the cardiovascular diseases, but the burgeoning, aging population in the forthcoming era may shoulder some unintended consequences. In all developed countries, both aging and an increase in metabolic syndrome will cause serious concerns, because the cardiovascular diseases directly related to these condition...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - August 25, 2014 Category: Cardiology Source Type: research

Development of type 2 diabetes mellitus thirty-one years after billroth ii in a patient asking for diabetes surgery.
CONCLUSIONS: The results generated by bariatric surgery are encouraging, but still do not clarify the precise way how surgery produces rapid improvement of systemic metabolism as in diabetes, but in our patient, the effect was quite different because the gastric bypass had no protective effect against diabetes. PMID: 25137284 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - August 25, 2014 Category: Nutrition Authors: Garciacaballero M, Reyes-Ortiz A, Toval JA, Martínez-Moreno JM, Miralles F Tags: Nutr Hosp Source Type: research

Effect of long-term physical exercise program and/or diet on metabolic syndrome in obese boys.
CONCLUSIONS: Detraining from a long-term exercise program (with or without diet) seems not to negatively affect the cardiovascular profile, suggesting that the program provides benefits and fosters healthy habits that can be maintained over time, preventing the development of metabolic syndrome. PMID: 25137267 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - August 25, 2014 Category: Nutrition Authors: García Hermoso A, Saavedra García JM, Escalante González Y, Domínguez Pachón AM Tags: Nutr Hosp Source Type: research

Prevalence of metabolic syndrome in human immunodeficiency virus - infected patients from the South-West region of Cameroon, using the adult treatment panel III criteria
Conclusions: In this study, HAART but not HIV disease plays a significant role in the development of MS. The metabolic complications as a result of treatment with HAART may predispose HIV patients to developing cardiovascular diseases and diabetes, in spite of improvements in morbidity and mortality conferred by immune reconstitution as a result of HAART treatment. (Source: BioMed Central)
Source: BioMed Central - August 25, 2014 Category: Journals (General) Authors: Herbert Afegenwi MbunkahHenry Dilonga MerikiAnthony Tufon KukwahOmarine NforTheresa Nkuo-Akenji Source Type: research

Neonatal monosodium glutamate treatment causes obesity, diabetes, and macrovesicular steatohepatitis with liver nodules in DIAR mice
ConclusionsDIAR‐MSG had NASH‐like liver pathology and liver nodules typically associated with MS symptoms. DIAR‐MSG provides a valuable animal model to analyze NASH pathogenesis and carcinogenesis. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - August 25, 2014 Category: Gastroenterology Authors: Koichi Tsuneyama, Takeshi Nishida, Hayato Baba, Shu Taira, Makoto Fujimoto, Kazuhiro Nomoto, Shinichi Hayashi, Shigeharu Miwa, Takahiko Nakajima, Mitsuko Sutoh, Emu Oda, Ryoji Hokao, Johji Imura Tags: Hepatology Source Type: research

Different Risk Factor Profiles for Ischemic and Hemorrhagic Stroke in Type 1 Diabetes Mellitus [Clinical Sciences]
Conclusions— The risk factor profile for ischemic stroke seems partly different from that of hemorrhagic stroke in patients with type 1 diabetes mellitus. (Source: Stroke)
Source: Stroke - August 25, 2014 Category: Neurology Authors: Hagg, S., Thorn, L. M., Forsblom, C. M., Gordin, D., Saraheimo, M., Tolonen, N., Waden, J., Liebkind, R., Putaala, J., Tatlisumak, T., Groop, P.-H., on behalf of the FinnDiane Study Group Tags: Risk Factors, Type 1 diabetes, Acute Cerebral Hemorrhage, Acute Cerebral Infarction Clinical Sciences Source Type: research

Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content
This article mainly reviews the modulation of apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins in adipocyte triglyceride content. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - August 23, 2014 Category: Lipidology Authors: Yan-hong LiLing Liu Source Type: research

Clinical and prognostic significance of increased liver enzymes in ST-elevation myocardial infarction
Several lines of evidence documented a relation between elevated transaminases and atherosclerosis, independent of classic risk factors, including the metabolic syndrome (1,2). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 23, 2014 Category: Cardiology Authors: Chiara Lazzeri, Serafina Valente, Maria Boddi, Valerio Mecarocci, Marco Chiostri, Gian Franco Gensini Source Type: research

Osteocalcin, energy and glucose metabolism
Osteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on pancreatic beta cells and adipose tissue. Undercarboxylated osteocalcin is the hormonally active isoform and stimulates insulin secretion and enhances insulin sensitivity in adipose tissue and muscle. Insulin and leptin, in turn, act on bone tissue, modulating the osteocalcin secretion, in a traditional feedback mechanism that places the skeleton as a true endocrine organ. Fur...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - August 22, 2014 Category: Endocrinology Source Type: research

Laparoscopic gastric banding resolves the metabolic syndrome and improves lipid profile over five years in obese patients with Body Mass Index 30 – 40 kg/m
Obesity, metabolic syndrome (MS) and dyslipidemia are independent risk factors for cardiovascular disease. Bariatric surgery is increasingly recognized as an effective intervention for improving each of these risk factors. There are sparse data on the long-term durability of metabolic changes associated with bariatric surgery, in particular with laparoscopic gastric banding (LGB). Our objective was to evaluate the durability of metabolic changes associated with LGB in nonmorbid obesity. (Source: Atherosclerosis)
Source: Atherosclerosis - August 22, 2014 Category: Cardiology Authors: Sean P. Heffron, Amita Singh, Jonathan Zagzag, Heekoung A. Youn, James A. Underberg, George A. Fielding, Christine J. Ren-Fielding Source Type: research

Aortic stiffness evaluation in patients with metabolic syndrome; antihypertensive drugs and statins should be considered.
PMID: 25163086 [PubMed - as supplied by publisher] (Source: The Anatolian Journal of Cardiology)
Source: The Anatolian Journal of Cardiology - August 22, 2014 Category: Cardiology Authors: Varol E, Ozaydın M Tags: Anadolu Kardiyol Derg Source Type: research

Estradiol prevents fat accumulation and overcomes leptin resistance in female high fat diet mice.
In conclusion, differences in response to E2 treatment of HFD fed animals depend on their endogenous estrogenic status. Overall, E2 administration overcomes arcuate leptin resistance and partially prevents fat accumulation on these mice. PMID: 25147981 [PubMed - as supplied by publisher] (Source: Endocrinology)
Source: Endocrinology - August 22, 2014 Category: Endocrinology Authors: Litwak SA, Wilson JL, Chen W, Garcia-Rudaz C, Khaksari M, Cowley MA, Enriori PJ Tags: Endocrinology Source Type: research

Omentin changes following bariatric surgery and predictive links with biomarkers for risk of cardiovascular disease
Background: Although no receptor has yet been identified, changes in circulating levels of the adipokine designated as Omentin have been demonstrated in obesity and related comorbidities such as cardiovascular disease, insulin resistance, metabolic syndrome and chronic inflammation. Methods: Changes in Omentin levels at 1 and 5?days and 6 and 12?months in response to biliopancreatic diversion with duodenal switch bariatric surgery were evaluated, specifically to investigate if changes preceded gain of insulin sensitivity. Results: Pre-operative plasma Omentin was not different between men (n?=?18) vs women (n?=?48), or dia...
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Marc LapointePaul PoirierJulie MartinMarjorie BastienAudrey AuclairKatherine Cianflone Source Type: research

The separate and combined effects of adiposity and cardiometabolic dysfunction on the risk of recurrent cardiovascular events and mortality in patients with manifest vascular disease
Conclusions In patients with vascular disease, the cardiometabolic consequences of adiposity rather than adiposity per se increase the risk of recurrent cardiovascular events and mortality. (Source: Heart)
Source: Heart - August 21, 2014 Category: Cardiology Authors: van der Leeuw, J., van der Graaf, Y., Nathoe, H. M., de Borst, G. J., Kappelle, L. J., Visseren, F. L. J., van Petersen, Pijl, Algra, van der Graaf, Grobbee, Rutten, Visseren, Moll, Kappelle, Mali, Doevendans, on behalf of the SMART study group Tags: Editor's choice, Drugs: cardiovascular system, Epidemiology Cardiac risk factors and prevention Source Type: research

Recurrent hepatitis C after liver transplant.
Abstract End stage liver disease from hepatitis C is the most common indication for liver transplantation in many parts of the world accounting for up to 40% of liver transplants. Antiviral therapy either before or after liver transplantation is challenging due to side effects and lower efficacy in patients with cirrhosis and liver transplant recipients, as well as from drug interactions with immunosuppressants. Factors that may affect recurrent hepatitis C include donor age, immunosuppression, IL28B genotype, cytomegalovirus infection, and metabolic syndrome. Older donor age has persistently been shown to have the...
Source: World Journal of Gastroenterology : WJG - August 21, 2014 Category: Gastroenterology Authors: deLemos AS, Schmeltzer PA, Russo MW Tags: World J Gastroenterol Source Type: research

Adiponectin predicts MMP‐2 activity independently of obesity.
ConclusionIn this study we observed that adiponectin levels predicted MMP‐2 plasma activity independently of obesity. This finding suggests that the inflammatory process, associated with the highest CVD risk, would be involved in MMPs vascular production.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - August 21, 2014 Category: Journals (General) Authors: Verónica Miksztowicz, Nahuel Fernandez Machulsky, Diego Lucero, Eduardo Fassio, Laura Schreier, Gabriela Berg Tags: Original Article Source Type: research

The Metabolic Syndrome and DYRK1B
New England Journal of Medicine, Volume 371, Issue 8, Page 784-786, August 2014. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - August 20, 2014 Category: Internal Medicine Tags: article Source Type: research

Physical Exercise Restores Microvascular Function in Obese Rats with Metabolic Syndrome
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - August 20, 2014 Category: Endocrinology Tags: article Source Type: research

Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population
Background: Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population. Methods: We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography. Results: The prevalence of MetS was ...
Source: BMC Cardiovascular Disorders - August 20, 2014 Category: Cardiology Authors: Ki-Bum WonHyuk-Jae ChangJimin SungSanghoon ShinIn-Jeong ChoChi-Young ShimGeu-Ru HongYoung Jin KimByung-Wook ChoiNamsik Chung Source Type: research

Long-term inhibition of miR-21 leads to reduction of obesity in db/db mice.
CONCLUSIONS: Long-term treatment with LNA-21 is safe and efficiently suppresses miR-21 expression. Cardiac function was not affected. LNA-21 treatment led to a significant weight loss and reduces adipocyte size as well as derepression of the targets TGFRB2, PTEN, and Sprouty1 and 2. PMID: 25141837 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - August 20, 2014 Category: Eating Disorders and Weight Management Authors: Seeger T, Fischer A, Muhly-Reinholz M, Zeiher AM, Dimmeler S Tags: Obesity (Silver Spring) Source Type: research

Dose-dependent effects of rosuvastatin on the plasma sphingolipidome and phospholipidome in the metabolic syndrome.
Conclusions: Rosuvastatin dose-dependently lowers plasma sphingolipids and phospholipids, independent of LDL lowering, in men with the metabolic syndrome. PMID: 25140396 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 20, 2014 Category: Endocrinology Authors: Ng TW, Ooi EM, Watts GF, Chan DC, Weir JM, Meikle PJ, Barrett PH Tags: J Clin Endocrinol Metab Source Type: research

Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - August 19, 2014 Category: Endocrinology Tags: article Source Type: research

The Effect of Insulin Resistance on Breast Cancer Risk in Latinas of Mexican Origin
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - August 19, 2014 Category: Endocrinology Tags: article Source Type: research

Is Non–High-Density Lipoprotein Cholesterol a Marker and Therapeutic Target for Dyslipidemia in Metabolic Syndrome?
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - August 19, 2014 Category: Endocrinology Tags: article Source Type: research

Analysis of Metabolic Syndrome Components in >15 000 African Americans Identifies Pleiotropic Variants: Results From the Population Architecture Using Genomics and Epidemiology Study [Original Articles]
Conclusions— We highlight a method to increase power in large-scale genomic association analyses and report a novel variant associated with all MetS components in African Americans. We also identify pleiotropic associations that may be clinically useful in patient risk profiling and for informing translational research of potential gene targets and medications. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - August 19, 2014 Category: Cardiology Authors: Carty, C. L., Bhattacharjee, S., Haessler, J., Cheng, I., Hindorff, L. A., Aroda, V., Carlson, C. S., Hsu, C.-N., Wilkens, L., Liu, S., Selvin, E., Jackson, R., North, K. E., Peters, U., Pankow, J. S., Chatterjee, N., Kooperberg, C. Tags: Genomics, Epidemiology, Genetics of cardiovascular disease, Lipid and lipoprotein metabolism Original Articles Source Type: research

Critical periods of increased fetal vulnerability to a maternal high fat diet
Conclusions: This model defines that there are critical periods during gestation in which the fetus is actively shaped by the environment. Early exposure to a HF diet determines litter size while exposure to HF during the second half of pregnancy leads to dysregulation of expression of key genes responsible for fetal growth, hepatic glucose production and oxidative stress. These findings underscore the importance of future studies designed to clarify how these critical periods may influence future risk of developing MetS later in life. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - August 18, 2014 Category: Endocrinology Authors: Maria PlataLyda WilliamsYoshinori SekiKirsten HartilHarpreet KaurChia-Lei LinAriana FialloAlan GlennEllen KatzMamta FuloriaMaureen CharronPatricia Vuguin Source Type: research

Critical periods of increased fetal vulnerability to a maternal high fat diet.
CONCLUSIONS: This model defines that there are critical periods during gestation in which the fetus is actively shaped by the environment. Early exposure to a HF diet determines litter size while exposure to HF during the second half of pregnancy leads to dysregulation of expression of key genes responsible for fetal growth, hepatic glucose production and oxidative stress. These findings underscore the importance of future studies designed to clarify how these critical periods may influence future risk of developing MetS later in life. PMID: 25135621 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - August 18, 2014 Category: Reproduction Medicine Authors: Plata MD, Williams L, Seki Y, Hartil K, Kaur H, Lin CL, Fiallo A, Glenn AS, Katz EB, Fuloria M, Charron MJ, Vuguin PM Tags: Reprod Biol Endocrinol Source Type: research

Metabolic characterization of adults with binge eating in the general population: The framingham heart study.
CONCLUSIONS: Binge eating is associated with a high burden of metabolic risk factors. Much of the associated risk appears to be mediated by BMI, with the exception of fasting glucose. PMID: 25136837 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - August 18, 2014 Category: Eating Disorders and Weight Management Authors: Abraham TM, Massaro JM, Hoffmann U, Yanovski JA, Fox CS Tags: Obesity (Silver Spring) Source Type: research

The relationship between daily urinary sodium excretion and metabolic syndrome in patients with kidney transplantation.
Conclusions There is a significant relationship between daily urinary sodium excretion and metabolic syndrome in renal transplant recipients. The Turkish kidney transplantation patients consume a great amount of salt and salt intake is positively correlated with blood pressure. PMID: 25112485 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - August 17, 2014 Category: Transplant Surgery Authors: Unal A, Kocyigit I, Sipahioglu MH, Tokgoz B, Oymak O Tags: Ann Transplant Source Type: research

Genetics of metabolic syndrome.
Abstract Metabolic syndrome (MetS) is a cluster of metabolic traits associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. Central obesity and insulin resistance are thought to play key roles in the pathogenesis of the MetS. The MetS has a significant genetic component, and therefore linkage analysis, candidate gene approach, and genome-wide association (GWA) studies have been applied in the search of gene variants for the MetS. A few variants have been identified, located mostly in or near genes regulating lipid metabolism. GWA studies for the individual components of the MetS ha...
Source: ENDOCR REV - August 16, 2014 Category: Endocrinology Authors: Stančáková A, Laakso M Tags: Rev Endocr Metab Disord Source Type: research

Similar hypotensive effects of combined aerobic and resistance exercise with 1 set versus 3 sets in women with metabolic syndrome
In conclusion, a low‐volume RE combined with AE resulted in similar decrease of SBP when compared with RE with 3‐sets in women with MetS, which could be beneficial in situations of limited time. (Source: Clinical Physiology and Functional Imaging)
Source: Clinical Physiology and Functional Imaging - August 15, 2014 Category: Radiology Authors: Ramires A. Tibana, Dahan da C. Nascimento, Nuno M. F. Sousa, Jeeser A. Almeida, Milton R. Moraes, João Luiz Quagliotti Durigan, Scott R. Collier, Jonato Prestes Tags: Original Article Source Type: research

In vivo anti-hyperlipidemic activity of the triterpene from the stem bark of Protorhus longifolia (Benrh) Engl
Conclusions: The triterpene could effectively reduce or control the amount of serum cholesterol and LDL. It is apparent that the compound could contribute to new formulation with significant hypolipidemic effects. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - August 15, 2014 Category: Lipidology Authors: Kgothatso MachabaSinazo CobongelaRebamang MosaLawal OladipupoTrayana DjarovaAndy Opoku Source Type: research

Association between habitual daytime napping and metabolic syndrome: a population-based study
Our objective was to evaluate the association between habitual daytime napping and the prevalence of metabolic syndrome. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 15, 2014 Category: Biomedical Science Authors: Diaozhu Lin, Kan Sun, Feng Li, Yiqin Qi, Meng Ren, Chulin Huang, Juying Tang, Shengneng Xue, Yan Li, Li Yan Source Type: research

Seasonality of Metabolic Syndrome Characteristics in the Old Order Amish
Prior studies have found that Metabolic Syndrome (MetS) characteristics can vary by season. In order to test if these findings hold true in a predominantly rural/agricultural population, we examined the seasonality of MetS characteristics in a cross-sectional sample of Old Order Amish from Lancaster County, Pennsylvania. This population is a genetically homogeneous population of European ancestry with high levels of physical activity, limited medication use, and rates of obesity comparable to the national average. (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - August 14, 2014 Category: Epidemiology Authors: Jared A. Fisher, Robin C. Puett, Jeff D. Yanosky, Mary Pavlovich, Robert M. Reed, James Hibbert, Braxton D. Mitchell Tags: Abstracts Source Type: research

Association of Cystatin C with Measures of Obesity and Its Impact on Cardiovascular Events Among Healthy US Adults
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - August 14, 2014 Category: Endocrinology Tags: article Source Type: research