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Looking for New Herbal Treatments for Metabolic Syndrome.
Authors: Jang HJ, Um JY, Ko H, Chung WS PMID: 27340418 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 25, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

New diagnostic criteria for subclinical hypercortisolism using post‐surgical hypocortisolism: The Co‐work Of Adrenal Research (COAR) study
ConclusionsOur proposed model is able to accurately predict subtle cortisol excess and its chronic manifestations in patients with adrenal incidentaloma.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - June 25, 2016 Category: Endocrinology Authors: Seung Hun Lee, Kee‐Ho Song, Jinju Kim, Sooyoun Park, Seong Hee Ahn, Hyeonmok Kim, Yoon Young Cho, Sunghwan Suh, Beom‐Jun Kim, Jae Hyeon Kim, Jung‐Min Koh Tags: Original Article Source Type: research

A novel plasminogen activator inhibitor‐1 inhibitor, TM5441, protects against high fat diet‐induced obesity and adipocyte injury in mice
Conclusion and ImplicationsOur data suggest that TM5441 may become a novel therapeutic agent for obesity and obesity‐related metabolic disorders. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - June 24, 2016 Category: Drugs & Pharmacology Authors: Lingjuan Piao, Inji Jung, Joo Young Huh, Toshio Miyata, Hunjoo Ha Tags: RESEARCH PAPER Source Type: research

Modifiable Risk Factors for Periodontitis and Diabetes
Abstract This review describes the evidence published from January 2013 through March 2016 for modifiable risk factors for chronic periodontitis and diabetes mellitus. Risk factors are factors that increase the chance of developing the disease. Modifiable risk factors for both these chronic, inflammation-related diseases include the following: hyperglycemia; microbial overgrowth, infection, and inflammation (virus, poor oral hygiene, gut microbiome); overweight and obesity; metabolic syndrome; hyperlipidemia; medication; unhealthy diet (added sugar; alcohol and other non-sugary carbohydrates, fat, and meat; nutrit...
Source: Current Oral Health Reports - June 24, 2016 Category: Dentistry Source Type: research

DASH to stop metabolic syndrome
The Dietary Approach to Stop Hypertension (DASH) diet was designed to treat hypertension in adults. Clinical trials demonstrated that it was an effective nonpharmacologic therapy. However, it also has been recognized that some individuals have a DASH pattern of diet, with increased fruits, vegetables, whole grains, and low-fat dairy and decreased foods high in sugar and saturated fat, in the normal course of living. This has led to the question of whether individuals with this type of diet have a lower risk of developing hypertension and other cardiometabolic abnormalities. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 23, 2016 Category: Pediatrics Authors: Stephen R. Daniels Tags: The Editors' Perspective Source Type: research

Metabolic syndrome is associated with increased seminal inflammatory cytokines and reproductive dysfunction in a case‐controlled male cohort
ConclusionThe results suggest that MetS is associated with decreased fertility parameters in males, as well as local reproductive tract inflammation, in the absence of leukocytospermia. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - June 23, 2016 Category: Allergy & Immunology Authors: Kristian Leisegang, Patrick J. D. Bouic, Ralf R. Henkel Tags: Original Article Source Type: research

Preeclampsia and health risks later in life: an immunological link
Abstract Pregnancy represents a period of physiological stress, and although this stress is experienced for a very modest portion of life, it is now recognized as a window to women’s future health, often by unmasking predispositions to conditions that only become symptomatic later in life. In normal pregnancy, the mother experiences mild metabolic syndrome-like condition through week 20 of gestation. A pronounced phenotype of metabolic syndrome may program pregnancy complications such as preeclampsia. Preeclampsia is a serious complication with a myriad of manifestations for mother and offspring. This pregnancy ...
Source: Seminars in Immunopathology - June 23, 2016 Category: Pathology Source Type: research

The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling
Transmembrane protein 18 (TMEM18) is an ill-described, obesity-related gene, but few studies have explored its molecular function. We found single-nucleotide polymorphism data, suggesting that TMEM18 may be involved in the regulation/physiology of metabolic syndrome based on associations with insulin, homeostatic model assessment-β (HOMAβ), triglycerides, and blood sugar. We then found an ortholog in the Drosophila genome, knocked down Drosophila Tmem18 specifically in insulin-producing cells, and tested for its effects on metabolic function. Our results suggest that TMEM18 affects substrate levels through insuli...
Source: Journal of Endocrinology - June 23, 2016 Category: Endocrinology Authors: Wiemerslage, L., Gohel, P. A., Maestri, G., Hilmarsson, T. G., Mickael, M., Fredriksson, R., Williams, M. J., Schioth, H. B. Tags: Research Source Type: research

Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Abstract Autophagy, which is critical for the proper turnover of organelles such as endoplasmic reticulum and mitochondria, affects diverse aspects of metabolism, and its dysregulation has been incriminated in various metabolic disorders. However, the role of autophagy of myeloid cells in adipose tissue inflammation and type 2 diabetes has not been addressed. We produced mice with myeloid cell-specific deletion of Atg7 (autophagy-related 7), an essential autophagy gene (Atg7 conditional knockout [cKO] mice). While Atg7 cKO mice were metabolically indistinguishable from control mice, they developed diabetes when bre...
Source: Autophagy - June 23, 2016 Category: Cytology Authors: Lee HY, Kim J, Quan W, Lee JC, Kim MS, Kim SH, Bae JW, Hur KY, Lee MS Tags: Autophagy Source Type: research

Elevated triglycerides are associated with decreased executive function among adolescents with bipolar disorder
ConclusionElevated triglycerides are associated with poorer executive function among adolescents with BD. Studies of behavioural and pharmacological interventions targeting MetS components for the purpose of improving executive function among adolescents with BD are warranted. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - June 22, 2016 Category: Psychiatry Authors: M. R. Naiberg, D. F. Newton, J. E. Collins, D. P. Dickstein, C. R. Bowie, B. I. Goldstein Tags: Original Article Source Type: research

Glycated hemoglobin A1c level is associated with high urinary albumin/creatinine ratio in non-diabetic adult population.
CONCLUSION: Non-DM participants with relatively high HbA1c levels should be closely monitored for UACR, especially if participants do not have MetS. KEY MESSAGES HbA1c level was positively associated with the proportion of participants with a high UACR and logUACR in participants without DM. For participants without MetS, the proportion of participants with a high UACR was greater in the High group than in the other groups and logUACR was greatest in the High group compared to the other groups. For participants with MetS, there were significant associations between HbA1c and the proportion of participants with a high UACR ...
Source: Annals of Medicine - June 22, 2016 Category: Internal Medicine Tags: Ann Med Source Type: research

Association of serum ferritin levels with metabolic syndrome and insulin resistance in a Chinese population
Increased iron is associated with type 2 diabetes, dyslipidemia, and high blood pressure. Therefore, serum ferritin may be a suitable biomarker to detect metabolic syndrome (MetS). We investigated the relationship between serum ferritin, and the prevalence of MetS and insulin resistance (IR). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 22, 2016 Category: Endocrinology Authors: Ling Chen, Yufeng Li, Fang Zhang, Simin Zhang, Xianghai Zhou, Linong Ji Source Type: research

Curcumin and insulin resistance—Molecular targets and clinical evidences
Abstract Curcumin ((1E,6E)−1,7‐bis(4‐hydroxy‐3‐methoxyphenyl)‐1,6‐heptadiene‐3,5‐dione), the main component of the Indian spice turmeric, has been used in traditional medicine to improve diabetes and its comorbidities. Since the last two decades, scientific research has shown that in addition to its antioxidant properties, curcumin could also work as protein homeostasis regulator and it is able to modulate other intracellular pathways. Curcumin supplementation has been proposed to improve insulin resistance (IR) through the activation of the insulin receptor and its downstream pathways in several experime...
Source: BioFactors - June 21, 2016 Category: Biochemistry Authors: Angélica Saraí Jiménez‐Osorio, Adriana Monroy, Silvestre Alavez Tags: Review Article Source Type: research

Endothelial dysfunction biomarker, endothelial cell‐specific molecule‐1, and pediatric metabolic syndrome
ConclusionsSerum endocan level in pediatric MetS patients could be an important indicator of cardiovascular risk in adulthood. (Source: Pediatrics International)
Source: Pediatrics International - June 21, 2016 Category: Pediatrics Authors: Iclal Halici, Saziye Sezin Palabiyik, Fatma Guducu‐Tufekci, Asli Ozbek‐Bilgin, Atilla Cayir Tags: Original Article Source Type: research

The Role of Metabolic Surgery on Blood Pressure Control
Abstract Obesity and hypertension are growing epidemics in the modern world. Lifestyle changes and medical treatment for obesity have disappointing long-term results and albeit drugs for hypertension are usually very effective, the necessity of multiple pills and frequent side effects make the adherence to treatment a huge challenge for healthcare systems. Bariatric/metabolic surgery is a very effective treatment and an exponential number of studies have been showing its positive impact beyond weight loss, mainly on type 2 diabetes. There is also growing evidence suggesting that bariatric/metabolic surgery is ass...
Source: Current Atherosclerosis Reports - June 21, 2016 Category: Cardiology Source Type: research

Early Low-Fat Diet Enriched With Linolenic Acid Reduces Liver Endocannabinoid Tone and Improves Late Glycemic Control After a High-Fat Diet Challenge in Mice
Evidence suggests that alterations of glucose and lipid homeostasis induced by obesity are associated with the elevation of endocannabinoid tone. The biosynthesis of the two main endocannabinoids, N-arachidonoylethanolamine and 2-arachidonoyl-glycerol, which derive from arachidonic acid, is influenced by dietary fatty acids (FAs). We investigated whether exposure to n-3 FA at a young age may decrease tissue endocannabinoid levels and prevent metabolic disorders induced by a later high-fat diet (HFD) challenge. Three-week-old mice received a 5% lipid diet containing lard, lard plus safflower oil, or lard plus linseed oil fo...
Source: Diabetes - June 21, 2016 Category: Endocrinology Authors: Demizieux, L.; Piscitelli, F.; Troy-Fioramonti, S.; Iannotti, F. A.; Borrino, S.; Gresti, J.; Muller, T.; Bellenger, J.; Silvestri, C.; Di Marzo, V.; Degrace, P. Tags: Metabolism Source Type: research

Relative hypocortisolism is associated with obesity and the metabolic syndrome in recurrent affective disorders
Cardiovascular disease (CVD) is one of the main causes of excess deaths in affective disorders. Affective disorders are associated with increased frequencies of CVD risk-factors such as obesity, dyslipidemia, and metabolic syndrome. Stress-induced chronic cortisol excess has been suggested to promote obesity and metabolic syndrome. Chronic stress with frequent or persisting hypothalamic-pituitary-adrenal-axis (HPA-axis) hyperactivity may, over time, lead to a state of low HPA-axis activity, also denoted hypocortisolism. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - June 21, 2016 Category: Neurology Authors: Martin Maripuu, Mikael Wikgren, Pontus Karling, Rolf Adolfsson, Karl-Fredrik Norrback Source Type: research

Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - June 20, 2016 Category: Biochemistry Authors: Gaurav Pandey, Kripa Shankar, Ekta Makhija, Anil Gaikwad, Carolyn Ecelbarger, Anil Mandhani, Aneesh Srivastava, Swasti Tiwari Tags: Article Source Type: research

Traditional Chinese Medicine for Metabolic Syndrome via TCM Pattern Differentiation: Tongue Diagnosis for Predictor.
Authors: Lee TC, Lo LC, Wu FC Abstract Metabolic syndrome is a morbid condition, which is manifested by central obesity, abnormal glucose tolerance, lipodystrophy, and hypertension. Traditional Chinese medicine (TCM) clarifies that obesity is classified as phlegm-dampness. It is often accompanied with qi stagnation and blood stasis. One hundred and two overweight adults, who did not receive lipid-lowering drugs, were enrolled for analysis. The exclusion criteria were adults having malignancy disease, DM, and renal disease or who were pregnant or lactating. The study was divided into two groups: metabolic syndrome g...
Source: Evidence-based Complementary and Alternative Medicine - June 19, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet.
Authors: Liu Z, Dou W, Ni Z, Wen Q, Zhang R, Qin M, Wang X, Tang H, Cao Y, Wang J, Zhao S Abstract Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Insulin resistance (IR) is important in the development and progression of NAFLD. Nuclear erythroid 2‑related factor 2 (Nrf2) has previously been reported to be a novel regulator in NAFLD. The present study determined that Nrf2 knockdown accelerated the onset of obesity and non‑alcoholic steatohepatitis (NASH), via the induction of hepatic IR in mice fed a high‑fat diet (HFD), which was confirmed by an increase in ...
Source: Molecular Medicine Reports - June 19, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of leptin and leptin receptor SNPs on clinical- and metabolic-related traits in apparent treatment-resistant hypertension.
Authors: de Faria AP, Ritter AM, Sabbatini AR, Modolo R, Moreno H Abstract Leptin is associated to the lack of blood pressure control as well as target organ damage in resistant hypertensive (RH) subjects. Single-nucleotide polymorphisms (SNPs) rs7799039 and rs1137101 in leptin (LEP) and leptin receptor (LEPR) genes, respectively, are associated with cardiovascular disease and metabolic syndrome. We evaluated the association of these two SNPs with clinical and biochemical features in 109 apparent treatment-RH subjects (aTRH) and 125 controlled hypertensives. Homozygous genotypes GG (n = 43) vs. AA (n = 14) ...
Source: Blood Pressure - June 18, 2016 Category: Hematology Tags: Blood Press Source Type: research

Assessment of healthy behaviors for metabolic syndrome among Korean adults: a modified information-motivation-behavioral skills with psychological distress
Since the worldwide incidence of metabolic syndrome (Mets) has rapidly increased, healthy behaviors such as weight control, engaging in physical activity, and healthy diet have been crucial in the management o... (Source: BMC Public Health)
Source: BMC Public Health - June 18, 2016 Category: Consumer Health News Authors: Guna Lee, Sook Ja Yang and Yeon Kyung Chee Source Type: research

Inositol(s) in thyroid function, growth and autoimmunity
Abstract Myo-inositol and phosphatidylinositol(s) play a pivotal function in many metabolic pathways that, if impaired, impact unfavorably on human health. This review analyzes several experimental and clinical investigations regarding the involvement of this class of molecules in physiological and pathological situations, with a major focus on thyroid. Central issues are the relationship between phosphatidylinositol and thyrotropin (TSH) signaling on one hand, and phosphatydylinositol and autoimmunity on the other hand. Other issues are the consequences of malfunction of some receptors, such as those ones for TSH...
Source: Reviews in Endocrine and Metabolic Disorders - June 18, 2016 Category: Endocrinology Source Type: research

Complication in diabetic nephropathy
Publication date: Available online 18 June 2016 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Sharon John, Li Xiao Ning Background Diabetic kidney disease is the most common cause of chronic kidney disease, leading to end-stage renal disease (ESRD) and premature death. In addition, it negatively affects a patient’s quality of life and social environment, and poses a burden on national health care budgets. Although various therapeutic approaches, such as hypoglycemic agents, antihypertensive drugs, and renin-angiotensin system inhibitors, have been tried to slow the progr...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - June 18, 2016 Category: Endocrinology Source Type: research

Understanding Diabetic Foot Infection and its Management
Publication date: Available online 18 June 2016 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Saba Noor, Rizwan Ullah Khan, Jamal Ahmad Diabetic Foot Ulcers (DFUs), a dreadful micro-vascular complication is liable for substantial increase in morbidity and mortality. DFU is a complicated amalgam of neuropathy, peripheral arterial diseases, foot deformities and infection. Spanning the spectrum from superficial cellulitis, microbial flora leads to chronic ostemyelitis and gangrenous extremity lower limb amputations. Wounds without affirmation of soft tissue or bone infection...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - June 18, 2016 Category: Endocrinology Source Type: research

Serum uric acid level as a determinant of the metabolic syndrome: A case control study
Conclusion The current multivariate regression analysis clearly infers that uric acid can be considered as a marker and potential modifier of metabolic syndrome. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - June 18, 2016 Category: Endocrinology Source Type: research

Medical Cost of Type 2 Diabetes Attributable to Physical Inactivity in the United States in 2012
Conclusions This study shows that billions of dollars could be saved annually just in terms of type 2 diabetes cost in the U.S., if the entire adult population met physical activity guidelines. Physical activity promotion, particularly at the environmental and policy level should be a priority in the population. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - June 18, 2016 Category: Endocrinology Source Type: research

Treatment of Hyperlipidemia Changes With Level of Kidney Function—Rationale
Publication date: July 2016 Source:Advances in Chronic Kidney Disease, Volume 23, Issue 4 Author(s): Shubha Ananthakrishnan, George A. Kaysen Lipoprotein abnormalities such as low levels of high-density lipoprotein (HDL) and high triglycerides (TGs), associated with the metabolic syndrome, are also associated with subsequent decline in kidney function. Patients with end-stage kidney disease also exhibit low HDL and high TGs and a modest reduction in low-density lipoprotein (LDL), although the mechanisms responsible for these changes differ when patients with end-stage kidney disease are compared with those having metab...
Source: Advances in Chronic Kidney Disease - June 18, 2016 Category: Urology & Nephrology Source Type: research

Inositol(s) in thyroid function, growth and autoimmunity.
Abstract Myo-inositol and phosphatidylinositol(s) play a pivotal function in many metabolic pathways that, if impaired, impact unfavorably on human health. This review analyzes several experimental and clinical investigations regarding the involvement of this class of molecules in physiological and pathological situations, with a major focus on thyroid. Central issues are the relationship between phosphatidylinositol and thyrotropin (TSH) signaling on one hand, and phosphatydylinositol and autoimmunity on the other hand. Other issues are the consequences of malfunction of some receptors, such as those ones for TSH ...
Source: ENDOCR REV - June 18, 2016 Category: Endocrinology Authors: Benvenga S, Antonelli A Tags: Rev Endocr Metab Disord Source Type: research

Lipid accumulation product (LAP) as a criterion for the identification of the healthy obesity phenotype in postmenopausal women.
Abstract Obesity and its complications constitute a major health problem in postmenopausal women. The identification of the obesity phenotype, especially that of metabolically healthy obese (MHO) patients, is a necessary part of obesity treatment protocols. There are several methods to define MHO, but unfortunately, all of them are arbitrary and inconsistent. The aim of this work was to determine whether lipid accumulation product (LAP) could be used as a marker of the MHO phenotype in postmenopausal women. A sample of 345 Polish postmenopausal women aged 50-60 years old participated in the study. Participants were...
Source: Experimental Gerontology - June 18, 2016 Category: Geriatrics Authors: Lwow F, Jedrzejuk D, Milewicz A, Szmigiero L Tags: Exp Gerontol Source Type: research

Clinical Significance of Determining Plasma MicroRNA33b in Type 2 Diabetic Patients with Dyslipidemia.
CONCLUSION: We postulated that plasma miRNA33b may be useful as a new metabolic biomarker of dyslipidemia in patients with T2DM as well as metabolic syndrome via an insulin/SREBP-1c/miRNA33b/ABCA1 pathway. PMID: 27301461 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 17, 2016 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Peripheral Blood Flow Regulation in Human Obesity and Metabolic Syndrome
Both obesity and metabolic syndrome are important cardiovascular disease risk factors. In this review, we explore the hypothesis that young obese adults and adults with metabolic syndrome exhibit alterations in blood flow regulation that occur before the onset of overt cardiovascular dysfunction. (Source: Exercise and Sport Sciences Reviews)
Source: Exercise and Sport Sciences Reviews - June 17, 2016 Category: Sports Medicine Tags: Articles Source Type: research

Association between food and nutrition insecurity with cardiometabolic risk factors in childhood and adolescence: a systematic review
Conclusions: Food and nutrition insecurity was associated with the presence of cardiometabolic risk factors in the assessed publications. Childhood and adolescence constitute a period of life that is vulnerable to food insecurity consequences, making it extremely important to ensure the regular and permanent access to food. Because this is a complex association, some difficulties are found, such as the synergy between risk factors, the assessment of heterogeneous groups and extrapolation of data to other populations, in addition to the influence of environmental factors.Resumo Objetivo: Abordar a associação entre insegur...
Source: Revista Paulista de Pediatria - June 17, 2016 Category: Pediatrics Source Type: research

Energy expenditure and nutritional complications of metabolic syndrome and rheumatoid cachexia in rheumatoid arthritis: an observational study using calorimetry and actimetry
Conclusion. Low levels of PA and treatment by glucocorticoids are associated with the nutritional complications of RA, suggesting the potential for therapeutic interventions. (Source: Rheumatology)
Source: Rheumatology - June 17, 2016 Category: Rheumatology Authors: Hugo, M., Mehsen-Cetre, N., Pierreisnard, A., Schaeverbeke, T., Gin, H., Rigalleau, V. Tags: Rheumatoid Arthritis CLINICAL SCIENCE Source Type: research

Molecules, Vol. 21, Pages 682: Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent
Increasing evidence from both experimental and clinical studies depicts the involvement of oxidative stress in the pathogenesis of various diseases. Specifically, disruption of homeostatic redox balance in accumulated body fat mass leads to obesity-associated metabolic syndrome. Strategies for the restoration of redox balance, potentially by exploring potent plant bioactives, have thus become the focus of therapeutic intervention. The present study aimed to bioprospect the potential use of the curculigoside-cinnamic acid-rich fraction from Molineria latifolia rhizome as an antioxidant therapeutic agent. The ethyl acetate f...
Source: Molecules - June 17, 2016 Category: Chemistry Authors: Der OoiKim ChanNadarajan SaregaNoorjahan AlitheenHairuszah IthninMaznah Ismail Tags: Article Source Type: research

Student-organized street screening for diabetes mellitus and metabolic syndrome: Mere celebration of World Diabetes Day or actual preventive and diagnostic step?
The prevalence of diseases of affluence and associated risk factors has been well-documented in most countries, including the Czech Republic (CZ) [1,2]. Random street screening and educational campaigns typically target diseases such as HIV and are primarily conducted in less-developed countries [3]; developed countries do not systematically perform such screenings. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - June 17, 2016 Category: Endocrinology Authors: Kristýna Kučerová, Marek Brabec, Denisa Janíčková Žďárská, Milan Kvapil, Jan Brož Source Type: research

Gestational diabetes mellitus in an Iranian pregnant population using IADPSG criteria: incidence, contributing factors and outcomes
Conclusion About one third of studied women diagnosed as GDM according to the IADPSG criteria. Risk factors of GDM were maternal age, family history of diabetes, Previous GDM, overweight and obesity before pregnancy, the same reported factors with 2 steps approach. Higher rate of GDM using this criterion may increase concern about healthcare costs and workloads. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - June 17, 2016 Category: Endocrinology Source Type: research

Obesity and diabetes: An update
Publication date: Available online 17 June 2016 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Shalini Verma, M. Ejaz Hussain The twin epidemic of obesity and diabetes is a major crisis globally. Several epidemiologic studies reveal the parallel escalation of obesity and diabetes. The term ‘diabesity’ expresses their close relationship to each other, wherein both these metabolic disorders are characterized by defects of insulin action. The pathophysiology connecting obesity and diabetes is chiefly attributed to two factors: insulin resistance and insulin deficiency. Rec...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - June 17, 2016 Category: Endocrinology Source Type: research

Diabetic Lower Extremity Complications, Fear of Falling and Associated HbA1c Levels: A Cross-Sectional Study of the East Harlem Population
This study assessed the ability of HbA1c to predict the total number of podiatric manifestations in diabetic patients. In the end, HbA1c was not a good predictor of the number of podiatric manifestations. The weak correlation between HbA1c levels and the total number of podiatric manifestations in this study might be due to the small sample size. Future studies, ideally involving a larger sample size, are needed to more accurately assess the potential of HbA1c for predicting lower extremity complications. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - June 17, 2016 Category: Endocrinology Source Type: research

Leukocyte‐bound Apolipoprotein B in the Circulation is Inversely Associated with the Presence of Clinical and Subclinical Atherosclerosis
ConclusionUnexpectedly, the presence of non‐internalized apo B‐containing lipoproteins on circulating neutrophil and monocyte membranes may represent a protective mechanism against atherosclerosis.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 17, 2016 Category: Journals (General) Authors: Marijke A. de Vries, Boudewijn Klop, Noëlle van der Meulen, Gert‐Jan M van de Geijn, Lenneke Prinzen, Ellen van der Zwan, Erwin Birnie, Jan Willem Cohen Tervaert, Anho H. Liem, Wouter W. de Herder, Manuel Castro Cabezas Tags: Original Paper Source Type: research

Effect of a high-protein energy-restricted diet combined with resistance training on metabolic profile in older individuals with metabolic impairments
Abstract Adequate protein intake and resistance training are effective strategies to maintain muscle mass, but the effect of their combination on metabolic profile during weight loss remains to be determined in older adults. The main objective of this study was to determine the effect of a 16-week high-protein caloric restriction combined with resistance training on chronic disease risk factors in obese older individuals with metabolic impairments. A total of 26 overweight adults aged between 60 and 75 years (BMI 32.4 ± 3.9 kg/m2) with at least 2 factors of the metabolic syndrome participated in this study and we...
Source: The Journal of Nutrition, Health and Aging - June 17, 2016 Category: Nutrition Source Type: research

Sex- and age-specific associations between major depressive disorder and metabolic syndrome in two general population samples in Germany.
CONCLUSION: The data suggest that especially younger (presumably pre-menopausal) females with MDD are more likely to have MetS than those without major depressive disorders, and that age extenuates this association. PMID: 27299922 [PubMed - as supplied by publisher] (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - June 16, 2016 Category: Psychiatry Tags: Nord J Psychiatry Source Type: research

Anger Traits Associated With Cardiovascular Risk Biomarkers in the Metabolic Syndrome.
CONCLUSIONS: The SEM results suggest that CVD-risk biomarker variables in this MetS sample (a) associate into 2 distinct profiles and (b) that 1 profile associates with overt anger, whereas the other associates with covert hostility. These results could contribute to more personalized prevention and care in CVD patients. PMID: 27299759 [PubMed - in process] (Source: The Journal of Cardiovascular Nursing)
Source: The Journal of Cardiovascular Nursing - June 16, 2016 Category: Nursing Authors: Lemche AV, Chaban OS, Lemche E Tags: J Cardiovasc Nurs Source Type: research

Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects
ConclusionsThe levels of peroxiredoxin 4 are higher in patients with prediabetes, but are similar in subjects with and without insulin resistance, which suggests that the main factor for its increased levels is hyperglycemia and not insulin sensitivity state.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - June 16, 2016 Category: Endocrinology Authors: Antoaneta Gateva, Yavor Assyov, Tsvetelina Velikova, Zdravko Kamenov Tags: Original Article Source Type: research

Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations
Publication date: Available online 16 June 2016 Source:Cell Reports Author(s): Jessica L. Saben, Anna L. Boudoures, Zeenat Asghar, Alysha Thompson, Andrea Drury, Wendy Zhang, Maggie Chi, Andrew Cusumano, Suzanne Scheaffer, Kelle H. Moley Maternal obesity impairs offspring health, but the responsible mechanisms are not fully established. To address this question, we fed female mice a high-fat/high-sugar diet from before conception until weaning and then followed the outcomes in the next three generations of offspring, all fed a control diet. We observed that female offspring born to obese mothers had impaired...
Source: Cell Reports - June 16, 2016 Category: Cytology Source Type: research

Genetics of Insulin Resistance and the Metabolic Syndrome
Abstract Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk factors for the development of cardiovascular disease. They result from the interplay of environmental and genetic factors but the full extent of the genetic background to these conditions remains incomplete. Large-scale genome-wide association studies have helped advance the identification of common genetic variation associated with insulin resistance and the metabolic syndrome, and more recently, exome sequencing has allowed the identification of rare variants associated with the pathogenesis of these conditions. Ma...
Source: Current Cardiology Reports - June 16, 2016 Category: Cardiology Source Type: research

0370 : Prevalence and characteristics of metabolic syndrome in patients with acute coronary syndrome
Conclusion The MS has a high prevalence in patients with an acute coronary syndrome, especially in women. The most frequent components are hypertension and hyperglycemia. The identification of subjects with the MS is conceivably useful from a clinical standpoint, as it can be anticipated that these individuals should benefit from interventions aimed at reducing cardiovascular risk. The author hereby declares no conflict of interest (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - June 16, 2016 Category: Cardiology Source Type: research

Insulin Resistance: Vascular Function and Exercise
Publication date: Available online 9 June 2016 Source:Integrative Medicine Research Author(s): Moon-Hyon Hwang, Sewon Lee Insulin resistance associated with metabolic syndrome and type 2 diabetes mellitus is an epidemic metabolic disorder, which increases the risk of cardiovascular complications. Impaired vascular endothelial function is an early marker for atherosclerosis which causes cardiovascular complications. Both experimental and clinical studies indicate that endothelial dysfunction in vasculatures occurs with insulin resistance. The associated physiological mechanisms are not fully appreciated yet, but it seem...
Source: Integrative Medicine Research - June 16, 2016 Category: Complementary Medicine Source Type: research

Females, Hispanics and Older Individuals Are at Greatest Risk of Developing Metabolic Syndrome in the U.S.
Conclusions The high prevalence of MetS in the U.S. affects females, Hispanics, and older individuals the greatest. The aging population and increasing Hispanic population further highlight the huge burden of disease MetS will place on the healthcare system in the U.S. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - June 16, 2016 Category: Endocrinology Source Type: research

The relation of protein C and protein S levels with cardiovascular risk in patients with diabetic neuropathy
Conclusions We found that protein C and S levels were much lower in diabetic patients than non diabetics.There was no difference between diabetic patients with DN and diabetic patients without DN in terms of protein C and protein S levels. Further, we couldn’t detect any finding that we can say protein C and Protein S levels can be used as a cardiovascular risk assesment marker in diabetic neuropathic patients. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - June 16, 2016 Category: Endocrinology Source Type: research