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Adipose tissue remodeling in a novel domestic porcine model of diet-induced obesity.
CONCLUSIONS: A high-fat/high-fructose diet induces in domestic pigs many characteristics of metabolic syndrome, which is useful for investigating the effects of the obesity. PMID: 25627626 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 1, 2015 Category: Eating Disorders and Weight Management Authors: Pawar AS, Zhu XY, Eirin A, Tang H, Jordan KL, Woollard JR, Lerman A, Lerman LO Tags: Obesity (Silver Spring) Source Type: research

Comparative Changes of Lipid Levels in Treatment-Naive, HIV-1-Infected Adults Treated with Dolutegravir vs. Efavirenz, Raltegravir, and Ritonavir-Boosted Darunavir-Based Regimens Over 48 Weeks
Conclusions Together, these data show that dolutegravir has a safer lipid profile in combination ART and provides an important treatment option for older patients who may have other risk factors for metabolic syndrome or cardiovascular disease. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 31, 2015 Category: Drugs & Pharmacology Source Type: research

Nonalcoholic fatty liver disease as a potential risk factor of cardiovascular disease
Nonalcoholic fatty liver disease (NAFLD) is the hepatic component of the metabolic syndrome. The aim of this review is to summarize the available data linking NAFLD with cardiovascular disease (CVD). The following topics are reviewed: (a) the clinical evidence linking NAFLD to increased prevalence of CVD; (b) the relationship between NAFLD (which is diagnosed by liver biopsy, serum liver enzymes, or ultrasonography) and incidence of CVD; (c) the mechanism linking NAFLD to CVD and clinical implication; and (d) the potential impact of NAFLD treatment on cardiac complications. CVD dictates the outcome (or outcomes) in patient...
Source: European Journal of Gastroenterology and Hepatology - January 30, 2015 Category: Gastroenterology Tags: Review Articles Source Type: research

The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males.
In conclusion, CYP27A1 rs4674344 SNP, A/L ratio, and MetS are significantly associated and T-carriers might have a higher risk of developing MetS due to low A/L ratios in the preclinical stage. PMID: 25628655 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 30, 2015 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Serum uric acid levels are associated with hypertension and metabolic syndrome but not atherosclerosis in Chinese inpatients with type 2 diabetes
Objective: Serum uric acid (SUA) is associated with many cardiovascular risk factors such as hypertension (HTN) and metabolic syndrome (MetS). However, the association of SUA with atherosclerosis remains controversial. Our aim was to investigate the relationships of SUA with HTN, MetS and atherosclerosis in Chinese inpatients with type 2 diabetes. Methods: This cross-sectional study was performed with a sample of 2388 hospitalized Chinese patients with type 2 diabetes. Both carotid and lower limb atherosclerotic lesions were assessed for intima–media thickness, plaque and stenosis by Doppler ultrasound. Atherosclerotic p...
Source: Journal of Hypertension - January 30, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Recognizing and managing comorbidities in psoriatic arthritis
Purpose of review: Many patients with psoriatic arthritis (PsA) have additional medical problems that can have an impact on morbidity and mortality. The goal of this review is to summarize the available evidence to date on the association of medical comorbidities with PsA and the implications these comorbidities have on prognosis, therapy selection and treatment response. Recent findings: Cardiovascular disease, metabolic syndrome, obesity, diabetes, fatty liver disease Crohn's disease, ophthalmic disease, depression and anxiety are common comorbidities associated with PsA. Additional comorbidities may include an elevated ...
Source: Current Opinion in Rheumatology - January 30, 2015 Category: Rheumatology Tags: EPIDEMIOLOGY AND HEALTH-RELATED SERVICES: Edited by M. Elaine Husni Source Type: research

Hypoadiponectinemia, cardiometabolic comorbidities and left ventricular hypertrophy
In conclusion, our data seem to indicate that hypoadiponectinemia might be associated with an increased prevalence both of clinical comorbidities and increased LVMI. In this subset of subjects, ADPN and BMI, more than MetS, are able to explain cardiac damage. Accordingly, ADPN might become a new target in the management of cardiometabolic risk. (Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - January 30, 2015 Category: Emergency Medicine Source Type: research

European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa
Abstract Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep‐seated, inflamed lesions in the apocrine gland‐bearing areas of the body, most commonly the axillae, inguinal and anogenital regions. A mean disease incidence of 6.0 per 100 000 person‐years and an average prevalence of 1% has been reported in Europe. HS has the highest impact on patients' quality of life among all assessed dermatological diseases. HS is associated with a variety of concomitant and secondary diseases, such as ...
Source: Journal of the European Academy of Dermatology and Venereology - January 30, 2015 Category: Dermatology Authors: C.C. Zouboulis, N. Desai, L. Emtestam, R.E. Hunger, D. Ioannides, I. Juhász, J. Lapins, L. Matusiak, E.P. Prens, J. Revuz, S. Schneider‐Burrus, J.C. Szepietowski, H.H. Zee, G.B.E. Jemec Tags: Review Article Source Type: research

Individuals at risk of metabolic syndrome are more likely to use a variety of dietary supplements
Discussion FeMS may be an independent predictor of dietary supplement use. Dietary supplement use is more common in older individuals and those with higher educational status. (Source: Advances in Integrative Medicine)
Source: Advances in Integrative Medicine - January 30, 2015 Category: Internal Medicine Source Type: research

Monocyte chemoattractant protein‐1 gene polymorphism and its serum level have an impact on anthropometric and biochemical risk factors of metabolic syndrome in Indian population
In conclusions, the MCP‐1 2518A>G (rs 1024611) polymorphism has significant impact on risk of MetS, and MCP‐1 level correlates with anthropometric and biochemical risk factors of MetS. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - January 30, 2015 Category: Genetics & Stem Cells Authors: A. K. Madeshiya, S. Singh, S. Dwivedi, K. S. Saini, R. Singh, S. Tiwari, R. Konwar, A. Ghatak Tags: Original Article Source Type: research

Estimating the Association between Metabolic Risk Factors and Marijuana Use in US Adults Using Data from the Continuous National Health and Nutrition Examination Survey
More research is needed on the health impacts of marijuana use. Results of previous studies indicate that marijuana could alleviate certain factors of metabolic syndrome, such as obesity. (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - January 30, 2015 Category: Epidemiology Authors: Christin A. Thompson, Joel W. Hay Source Type: research

Lipids in hepatic glycogen storage diseases: pathophysiology, monitoring of dietary management and future directions
Abstract Hepatic glycogen storage diseases (GSD) underscore the intimate relationship between carbohydrate and lipid metabolism. The hyperlipidemias in hepatic GSD reflect perturbed intracellular metabolism, providing biomarkers in blood to monitor dietary management. In different types of GSD, hyperlipidemias are of a different origin. Hypertriglyceridemia is most prominent in GSD type Ia and associated with long-term outcome morbidity, like pancreatitis and hepatic adenomas. In the ketotic subtypes of GSD, hypertriglyceridemia reflects the age-dependent fasting intolerance, secondary lipolysis and increased mito...
Source: Journal of Inherited Metabolic Disease - January 29, 2015 Category: Internal Medicine Source Type: research

Longitudinal relationships of metabolic syndrome and obesity with kidney function: Healthy Twin Study
Conclusions MetS predicts prevalent CKD regardless of obesity, and obesity predicts incident CKD regardless of baseline MetS. Incident CKD is also associated with MetS at follow-up regardless of baseline MetS. These associations appear to be explained by shared environmental factors. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 29, 2015 Category: Urology & Nephrology Source Type: research

Relationship between cystatin C and metabolic syndrome among Chinese premenopausal and postmenopausal women without recognized chronic kidney disease
Conclusions: Higher serum Cys-C levels are positively and independently associated with the presence of MetS in Chinese premenopausal and postmenopausal women. Elevated Cys-C levels are significantly associated with postmenopause status. (Source: Menopause)
Source: Menopause - January 29, 2015 Category: OBGYN Tags: Original Articles Source Type: research

ChREBP binding and histone modifications modulate hepatic expression of the FASN gene in a metabolic syndrome rat model
Metabolic conditions such as hyperglycemia, hypertension, and lipid disorders and obesity are collectively referred to as the metabolic syndrome (MetS). These pathological conditions are associated with excessive caloric intake, and greatly increase mortalities related to cardiovascular disease [1, 2]. One of the major causes of the development of MetS is insulin resistance, which refers to a decrease in the action of insulin in peripheral tissues such as skeletal muscle, adipose tissue, and the liver. (Source: Nutrition)
Source: Nutrition - January 29, 2015 Category: Nutrition Authors: Takuji Suzuki, Takeshi Muramatsu, Kousuke Morioka, Toshinao Goda, Kazuki Mochizuk Source Type: research

Adverse cardiometabolic responses to exercise
Dalleck LC, Van Guilder GP, Richardson TB, Vella CA (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - January 28, 2015 Category: Endocrinology Source Type: research

Metabolic Inflammation in Inflammatory Bowel Disease: Crosstalk Between Adipose Tissue and Bowel
Abstract: Epidemiological studies show that both the incidence of inflammatory bowel disease (IBD) and the proportion of people with obesity and/or obesity-associated metabolic syndrome increased markedly in developed countries during the past half century. Obesity is also associated with the development of more active IBD and requirement for hospitalization and with a decrease in the time span between diagnosis and surgery. Patients with IBD, especially Crohn's disease, present fat-wrapping or “creeping fat,” which corresponds to ectopic adipose tissue extending from the mesenteric attachment and covering the majority...
Source: Inflammatory Bowel Diseases - January 28, 2015 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research

Fructose-induced metabolic syndrome decreases protein expression and activity of intestinal P-glycoprotein
Metabolic syndrome (MetS) is a health disorder that increases the risk of cardiovascular complications such as heart disease and type 2 diabetes. Some drugs used in patients with MetS are substrates of intestinal P-glycoprotein (P-gp), one of the most important efflux pumps that limit the absorption of xenobiotics. Thus, their bioavailability could be affected by changes in this transporter. Since one of the major causes of MetS in humans is an excessive sugar intake, the aim of this study was to evaluate the effect of a fructose-rich diet on intestinal P-gp activity and protein expression in male Sprague-Dawley rats. (Source: Nutrition)
Source: Nutrition - January 28, 2015 Category: Nutrition Authors: Analía Novak, Yanina Cynthia Godoy, Sonia Amalia Martinez, Carolina Inés Ghanem, Stella Maris Celuch Source Type: research

Treatment: Special Conditions - Metabolic Syndrome: Obesity and the Hypertension Connection
Individuals with a body mass index (BMI, Kg/square of height, m2) of 25-29.9 Kg/m2 are diagnosed as overweight and those with BMI >30 Kg/m2 as obese. Though slightly different diagnostic criteria exist, it is generally agreed that the metabolic syndrome (MS) is defined by the presence of three or more of the following: 1) increased waist circumference, (>40 inches for men and >35 inches for women), 2) increased triglycerides (> 150 mg/dl), 3) elevated blood pressure (>130/85 mmHg), 4) increased fasting glucose (>100 mg/dl), and 5) decreased high-density lipoprotein cholesterol ( (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - January 28, 2015 Category: Cardiology Authors: Efrain Reisin, Jonathan Owen Source Type: research

Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease
Abstract Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in western countries, being considered the hepatic manifestation of metabolic syndrome. Cumulative lines of evidence suggest that olive oil, used as primary source of fat by Mediterranean populations, may play a key role in the observed health benefits on NAFLD. In this review, we summarize the state of the art of the knowledge on the protective role of both major and minor components of olive oil on lipid metabolism during NAFLD. In particular, the biochemical mechanisms responsible for the increase or decrease in hepatic li...
Source: IUBMB Life - January 28, 2015 Category: Research Authors: Paola Priore, Alessandro Cavallo, Antonio Gnoni, Fabrizio Damiano, Gabriele V. Gnoni, Luisa Siculella Tags: Critical Review Source Type: research

The relationship between excessive daytime sleepiness and metabolic syndrome in severe obstructive sleep apnea syndrome
ConclusionEDS was independently correlated with sum of metabolic components in severe OSA patients. Our study suggested that EDS might be a potentially useful clinical marker to identify patients with severe OSA at risk of MetS. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 28, 2015 Category: Respiratory Medicine Authors: Jie‐feng Huang, Li‐Da Chen, Qi‐Chang Lin, Gong‐Ping Chen, Yao‐Hua Yu, Jian‐Chai Huang, Jian‐Ming Zhao Tags: Original Article Source Type: research

Sarcopenic obesity and dyslipidemia response to selective exercise program after liver transplantation
Conclusion Aerobic and resisted exercise has a positive effect in treatment of sarcopenic obesity and dyslipidemia (reducing fat mass, cholesterol and triglycerides levels while increasing muscle mass) post liver transplantation. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - January 28, 2015 Category: Genetics & Stem Cells Source Type: research

Metabolic disorders: stones as first clinical manifestation of significant diseases
Conclusion 24 hours urine evaluation and stone analysis which includes both morphological typing and infrared spectroscopy, are key diagnostic steps for early recognition of metabolic disorders. Metabolic screening allows diet related stone identification, points out stone risk factors and identifies patients’comorbidity. The occurrence of nephrocalcinosis with or without chronic renal failure should require a more detailed metabolic evaluation in order to identify uncommon etiologies such as renal tubular acidosis. (Source: World Journal of Urology)
Source: World Journal of Urology - January 27, 2015 Category: Urology & Nephrology Source Type: research

The sexual dimorphism of obesity
Publication date: 15 February 2015 Source:Molecular and Cellular Endocrinology, Volume 402 Author(s): Biff F. Palmer , Deborah J. Clegg The NIH has recently highlighted the importance of sexual dimorphisms and has mandated inclusion of both sexes in clinical trials and basic research. In this review we highlight new and novel ways sex hormones influence body adiposity and the metabolic syndrome. Understanding how and why metabolic processes differ by sex will enable clinicians to target and personalize therapies based on gender. Adipose tissue function and deposition differ by sex. Females differ with respect to distribu...
Source: Molecular and Cellular Endocrinology - January 27, 2015 Category: Endocrinology Source Type: research

Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats
Conclusion Decreased miR-144 could enhance TNF-α and IFN-γ production by targeting TLR2 in vitro, and might contribute to TLR2 up-regulation and the progression of NASH in HFD-MetS E3 rats. This might offer a novel and potential target for NASH therapy. (Source: Molecular and Cellular Endocrinology)
Source: Molecular and Cellular Endocrinology - January 27, 2015 Category: Endocrinology Source Type: research

Inverse association between central obesity and arterial stiffness in Korean subjects with metabolic syndrome: a cross-sectional cohort study
Background: Metabolic syndrome (MetS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. Whether central obesity (CeO) is a prerequisite for the diagnosis of MetS in the International Diabetes Federation (IDF) definition is a substantial issue because it may influence the clinical value of MetS for predicting subclinical atherosclerosis. Methods: We investigated the relation between MetS, as defined by the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III criteria, and arterial stiffness according to CeO status in 2,560 healthy Korean subjects who participat...
Source: Diabetology and Metabolic Syndrome - January 27, 2015 Category: Endocrinology Authors: Ki-Bum WonHyuk-Jae ChangHiroyuki NiinumaKoichiro NiwaKyewon JeonIn-Jeong ChoChi-Young ShimGeu-Ru HongNamsik Chung Source Type: research

Aldolase-B Knockout in Mice Phenocopies Hereditary Fructose Intolerance in Humans
Publication date: Available online 22 January 2015 Source:Molecular Genetics and Metabolism Author(s): Sarah A. Oppelt , Erin M. Sennott , Dean R. Tolan The rise in fructose consumption, and its correlation with symptoms of metabolic syndrome (MBS), has highlighted the need for a better understanding of fructose metabolism. To that end, valid rodent models reflecting the same metabolism as in humans, both biochemically and physiologically, are critical. A key to understanding any type of metabolism comes from study of disease states that affect such metabolism. A serious defect of fructose metabolism is the autosomal rec...
Source: Molecular Genetics and Metabolism - January 27, 2015 Category: Genetics & Stem Cells Source Type: research

Systemic inflammation is higher in peripheral artery disease than in stable coronary artery disease
The knowledge on the level of systemic inflammation in peripheral artery disease (PAD) is less well established than that in coronary artery disease (CAD). Systemic inflammation frequently coincides with atherosclerosis, but also with various traits of the metabolic syndrome (MetS). The individual contribution of CAD, PAD, and the MetS to inflammation is not known. (Source: Atherosclerosis)
Source: Atherosclerosis - January 27, 2015 Category: Cardiology Authors: Philipp Rein, Christoph H. Saely, Günther Silbernagel, Alexander Vonbank, Rainer Mathies, Heinz Drexel, Iris Baumgartner Source Type: research

Level of glycemic control and associated factors among DM patients in Ethiopia
Abebe SM, Berhane Y, Worku A, Alemu S, Mesfin N (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - January 26, 2015 Category: Endocrinology Source Type: research

The Impacts of Obesity on the Cardiovascular and Renal Systems: Cascade of Events and Therapeutic Approaches
Abstract There is a neglected epidemic of both obesity and metabolic syndrome in industrialized and unindustrialized countries all over the globe. Both conditions are associated with a high incidence of other serious pathologies, such as cardiovascular and renal diseases. In this article, we review the potential underlying mechanisms by which obesity and metabolic syndrome promote hypertension, including changes in cardiovascular–renal physiology induced by leptin, the sympathetic nervous system, the renin–angiotensin–aldosterone system, insulin resistance, free fatty acids, natriuretic peptides, and proinf...
Source: Current Hypertension Reports - January 26, 2015 Category: Primary Care Source Type: research

Low testosterone and non-alcoholic fatty liver disease: Evidence for their independent association in men with chronic spinal cord injury.
Conclusion The evidence of an independent association between NAFLD and low testosterone is strongly reinforced by its demonstration in men with chronic SCI, in spite of the many confounders peculiar to this population. PMID: 25614040 [PubMed - as supplied by publisher] (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - January 26, 2015 Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research

Dairy consumption and insulin sensitivity: A systematic review of short- and long-term intervention studies
Conclusions In adults, four of the dairy interventions showed a positive effect on insulin sensitivity as assessed by Homeostasis Model Assessment (HOMA); one was negative and five had no effect. As the number of weight stable intervention studies is very limited and participant numbers small, these findings need to be confirmed by larger trials in order to conclusively determine any relationship between dairy intake and insulin sensitivity. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - January 26, 2015 Category: Nutrition Source Type: research

Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations: A randomized crossover controlled intervention trial
Conclusion DHA-enriched canola oil exerts anti-inflammatory effects compared with polyunsaturated fatty acids from plant sources. CLINICALTRIALS.GOV REGISTRATION NUMBER AND DATE: NCT01351012; March 14, 2011. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - January 26, 2015 Category: Nutrition Source Type: research

Demystifying Nutritional Support in Cancer (FR451)
Central to managing nutrition in the cancer patient is recognizing and managing the anorexia-cachexia syndrome. Research characterizes the anorexia-cachexia syndrome as a metabolic syndrome associated with advanced cancer producing loss of muscle with or without the loss of fat mass. Its development is a turning point in the disease trajectory of a cancer patient, with continued weight loss associated with a shorter survival time, and it is responsible for death in up to 20% of cancer patients. Anorexia-cachexia is a significant cause of morbidity that manifests as weight loss, asthenia (loss of energy and strength), anemi...
Source: Journal of Pain and Symptom Management - January 25, 2015 Category: Palliative Care Authors: Eric Prommer, Thomas LeBlanc, Arif Kamal, Niki Koesel, Michele Szafranski Source Type: research

Understanding nutritional interventions and physical exercise in non-alcoholic Fatty liver disease.
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in adults and its prevalence is rising around the world. This pathology is characterized by accumulation of liver fat, which exceeds 5% of liver weight in absence of alcohol consumption, viral infection or other hepatic etiology. Since NAFLD has been associated with obesity, insulin resistance, diabetes or alteration of lipid profiles, it is considered as the liver manifestation of metabolic syndrome. Pathogenic mechanisms of NAFLD have not been clearly elucidated, but different events such as lipid accumulation, insulin resistance,...
Source: Current Molecular Medicine - January 25, 2015 Category: Molecular Biology Authors: Ordonez R, Carbajo-Pescador S, Mauriz JL, Gonzalez-Gallego J Tags: Curr Mol Med Source Type: research

The prevalence of the metabolic syndrome increases through the quartiles of thyroid stimulating hormone in a population-based sample of euthyroid subjects
Conclusion The prevalence of MetS increased with higher QTSH within the euthyroid range, mostly by an increase in the dyslipidemia. Arq Bras Endocrinol Metab. 2014;58(9):926-32 Objetivo O objetivo deste estudo foi avaliar a prevalência e características da síndrome metabólica (MetS) e seus elementos em relação ao TSH em sujeitos eutireoides. Materiais e métodos Foram analisados, em um estudo transversal, 2.153 adultos eutiroides, de 47,2 ± 14,5 anos (20-94) sem terapia antitiroidiana ou de reposição. Todos os participantes preencheram um questionário ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 25, 2015 Category: Endocrinology Source Type: research

Clinical evidence on potential health benefits of berries
Publication date: Available online 24 January 2015 Source:Current Opinion in Food Science Author(s): Baoru Yang , Maaria Kortesniemi Recent clinical evidence indicates potential of berry-rich diet in controlling the risk of chronic diseases. Acute consumption of berries ameliorates postprandial glycemic response, improves profile of circulating inflammatory markers and increases antioxidative capacity of plasma. Long-term intake of berries and berry products may improve plasma lipid profile, reduce chronic inflammation and support cardiovascular health, especially in population with baseline metabolic profile of increase...
Source: Current Opinion in Food Science - January 25, 2015 Category: Food Science Source Type: research

Incidence and Risk Factors for Metabolic Syndrome in Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients-a Tertiary Care Center Experience
Metabolic syndrome could be a complication of HSCT. Several mechanisms, including conditioning regimen-mediated damage to the neurohormonal system and vascular endothelium, and the immunological and inflammatory effects of the allogeneic graft and subsequent GVHD and its therapy may play a role. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Surabhi Batra, Karina Danner-Koptik, Morris Kletzel Tags: Late Effects/Quality of Life/Psychosocial Issues Source Type: research

Metabolic Syndrome Occurs within the First Year after Hematopoietic Cell Transplant
Improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) enables us to learn more about potential late complications after HCT, including metabolic syndrome (MS). This is the first study investigating the prevalence or development of metabolic syndrome within the first year post-HCT in adult myeloablative transplant recipients. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Kerry K. McMillen, Erin M. Schmidt, Barry E. Storer, Merav Bar Tags: Late Effects/Quality of Life/Psychosocial Issues Source Type: research

The preconceptional period as an opportunity for prediction and prevention of noncommunicable disease
Publication date: January 2015 Source:Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 29, Issue 1 Author(s): Eran Hadar , Eran Ashwal , Moshe Hod Preconceptional care is a set of interventions, aimed to identify and modify medical, behavioral, and social risks to a woman's health and her pregnancy outcome, prior to conception. Diagnosing and treating some of the common noncommunicable diseases (NCDs) may have an impact on pregnancy outcome. Ample time should be allowed to properly intervene in some of the following situations: hypertension, diabetes, obesity, systemic lupus erythematosu...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 24, 2015 Category: OBGYN Source Type: research

Lipid abnormalities in alpha/beta2-syntrophin null mice are independent from ABCA1
Publication date: Available online 24 January 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Tobias Hebel , Kristina Eisinger , Markus Neumeier , Lisa Rein-Fischboeck , Rebekka Pohl , Elisabeth M. Meier , Alfred Boettcher , Stanley C. Froehner , Marvin E. Adams , Gerhard Liebisch , Sabrina Krautbauer , Christa Buechler The syntrophins alpha (SNTA) and beta 2 (SNTB2) are molecular adaptor proteins shown to stabilize ABCA1, an essential regulator of HDL cholesterol. Furthermore, SNTB2 is involved in glucose stimulated insulin release. Hyperglycemia and dyslipidemia are cha...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 24, 2015 Category: Lipidology Source Type: research

Vida Sana : A Lifestyle Intervention for Uninsured, Predominantly Spanish-Speaking Immigrants Improves Metabolic Syndrome Indicators
We describe a ‘healthy lifestyles’ program implemented at a free clinic serving a predominantly Hispanic cohort of low-income, uninsured individuals living in Providence, Rhode Island. The “Vida Sana/Healthy Life” (Vida Sana) program uses low literacy, language-appropriate materials and trained peers to educate participants about healthy lifestyles in a setting that also provided opportunities for social engagement. 192 of 126 (65.6 %) participants in Vida Sana completed 6 out of 8 sessions of the Vida Sana program over a 12-month period. At the completion of the program, nearly 90 % of Vida Sana participants sho...
Source: Journal of Community Health - January 23, 2015 Category: Global & Universal Source Type: research

Metabolic Syndrome Predicts Restenosis After Carotid Endarterectomy
Metabolic syndrome is an independent predictor for restenosis after carotid endarterectomy (CEA). (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - January 23, 2015 Category: Surgery Authors: W.T. Williams, R. Assi, M.R. Hall Source Type: research

High prevalence of vitamin D insufficiency/deficiency in Dutch multi-ethnic obese children
Conclusion: Vitamin D insufficiency and deficiency is extremely prevalent in treatment-seeking obese ethnic children. However, there was no evidence of an effect of vitamin D status on various components of the metabolic syndrome in our cohort. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - January 23, 2015 Category: Pediatrics Source Type: research

Bilirubin is independently associated with oxidized LDL levels in young obese patients
Conclusions: Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 23, 2015 Category: Epidemiology Authors: Henrique NascimentoAna Inês AlvesSusana CoimbraCristina CatarinoDiana GomesElsa Bronze-da-RochaElísio CostaPetronila Rocha-PereiraLuísa AiresJorge MotaHelena Ferreira MansilhaCarla RêgoAlice Santos-SilvaLuís Belo Source Type: research

Pioglitazone adjunctive therapy for depressive episode of bipolar disorder: a randomized, double‐blind, placebo‐controlled trial
ConclusionThis study showed that pioglitazone could be a tolerable and effective adjunctive therapy for improving depressive symptoms in bipolar disorder without type 2 diabetes or metabolic syndrome. (Source: Depression and Anxiety)
Source: Depression and Anxiety - January 23, 2015 Category: Psychiatry Authors: Atefeh Zeinoddini, Maryam Sorayani, Elmira Hassanzadeh, Mohammad Arbabi, Mehdi Farokhnia, Samrand Salimi, Ali Ghaleiha, Shahin Akhondzadeh Tags: Research Article Source Type: research

Can the metabolic syndrome be explained by a unifying concept?
Publication date: February 2015 Source:The Lancet Diabetes & Endocrinology, Volume 3, Issue 2 Author(s): Paul Hjemdahl (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - January 23, 2015 Category: Endocrinology Source Type: research

Metabolic syndrome: a sympathetic disease?
Publication date: February 2015 Source:The Lancet Diabetes & Endocrinology, Volume 3, Issue 2 Author(s): Markus Schlaich , Nora Straznicky , Elisabeth Lambert , Gavin Lambert Metabolic syndrome is associated with adverse health outcomes and is a growing problem worldwide. Although efforts to harmonise the definition of metabolic syndrome have helped to better understand the prevalence and the adverse outcomes associated with the disorder on a global scale, the mechanisms underpinning the metabolic changes that define it are incompletely understood. Accumulating evidence from laboratory and human studies suggests ...
Source: The Lancet Diabetes and Endocrinology - January 23, 2015 Category: Endocrinology Source Type: research

Reduced Flexibility Associated with Metabolic Syndrome in Community-Dwelling Elders
Conclusion Reduced flexibility was positively associated with metabolic syndrome independent of age, gender, body composition, and functionality measurements in a community based geriatric population. Significant associations between metabolic syndrome with muscle strength and cardiorespiratory fitness in the elderly were not observed. Furthermore, flexibility should be included in the complete evaluation for metabolic syndrome. (Source: PLoS One)
Source: PLoS One - January 23, 2015 Category: Biomedical Science Authors: Ke-Vin Chang et al. Source Type: research

HbA1c as a screening test for hyperglycemia
Steylen PMJ, van der Heijden FMMA, Hoogendijk WJG, Verhoeven WMA (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - January 22, 2015 Category: Endocrinology Source Type: research