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Association of body mass index and waist circumference with subclinical atherosclerosis in retired NFL players.
CONCLUSIONS: In retired NFL players both BMI and WC were associated with CAC. Higher BMI may be associated with an increasing trend for the presence of CAC independent of WC. PMID: 25279867 [PubMed - indexed for MEDLINE] (Source: Southern Medical Journal)
Source: Southern Medical Journal - March 4, 2015 Category: Journals (General) Tags: South Med J Source Type: research

The association between metabolic syndrome and prostate cancer: Effect on cancer aggressiveness and progression
Conclusions Metabolic syndrome is associated with poorer findings in the radical prostatectomy specimens and is an independent prognostic factor of biochemical recurrence. (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - March 4, 2015 Category: Urology & Nephrology Source Type: research

Control of respiratory and cardiovascular functions by leptin
Publication date: 15 March 2015 Source:Life Sciences, Volume 125 Author(s): M. Bassi , W.I. Furuya , D.B. Zoccal , J.V. Menani , E. Colombari , J.E. Hall , A.A. da Silva , J.M. do Carmo , D.S.A. Colombari Leptin, a peptide hormone produced by adipose tissue, acts in brain centers that control critical physiological functions such as metabolism, breathing and cardiovascular regulation. The importance of leptin for respiratory control is evident by the fact that leptin deficient mice exhibit impaired ventilatory responses to carbon dioxide (CO2), which can be corrected by intracerebroventricular leptin replacement therapy....
Source: Life Sciences - March 4, 2015 Category: Biology Source Type: research

Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease.
Authors: Eslamparast T, Eghtesad S, Poustchi H, Hekmatdoost A Abstract Nonalcoholic fatty liver disease (NAFLD) is currently known as the most common liver problem, characterized by excessive lipid accumulation in hepatocytes, which may progress to other liver diseases such as nonalcoholic steatohepatitis, hepatic tissue fibrosis, liver cirrhosis, and failure or hepatocellular carcinoma. Since NAFLD is positively associated with the development of obesity, insulin resistance, and ultimately type 2 diabetes mellitus, it is often regarded as the hepatic manifestation of the metabolic syndrome. No pharmacologic treatm...
Source: World Journal of Hepatology - March 3, 2015 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Prevalence of metabolic syndrome and pre-metabolic syndrome in health professionals: LATINMETS Brazil study.
CONCLUSIONS: The LATINMETS Brazil study reported an association between MS prevalence and age, especially in those over 40 years. The presence of MS is associated with an increased prevalence of several cardiovascular risk factors. PMID: 25717347 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - March 3, 2015 Category: Endocrinology Authors: Vidigal Fde C, Ribeiro AQ, Babio N, Salas-Salvadó J, Bressan J Tags: Diabetol Metab Syndr Source Type: research

Efficacy of Lifestyle Changes in Subjects with Non-Alcoholic Liver Steatosis and Metabolic Syndrome May Be Improved with an Antioxidant Nutraceutical: A Controlled Clinical Study
Conclusion The results observed suggest that the use of a Eurosil 85®-based nutraceutical as a dietary adjunct with antioxidant properties potentially favours the efficacy of the dietary regimen alone and may possibly improve the subjects’ motivation to sustain such lifestyle changes over time. (Source: Drugs in R&D)
Source: Drugs in R&D - March 3, 2015 Category: Drugs & Pharmacology Source Type: research

Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum
Publication date: 30 March 2015 Source:Neuroscience Letters, Volume 591 Author(s): Ana C. Andreazza , Vilte E. Barakauskas , Salar Fazeli , Abigail Feresten , Li Shao , Vivien Wei , Che Hsuan Wu , Alasdair M. Barr , Clare L. Beasley Antipsychotics remain the standard of care for individuals with schizophrenia, despite their association with adverse effects including extrapyramidal symptoms, metabolic syndrome and agranulocytosis. While the biological mechanisms underlying these side effects remain unresolved, it has been proposed that oxidative stress may play a role in their development. The aim of this study was to eva...
Source: Neuroscience Letters - March 3, 2015 Category: Neuroscience Source Type: research

Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake [RESOURCE ARTICLE]
This study comprehensively describes the expression and function of eleven zebrafish apolipoproteins and serves as a springboard for future investigations to elucidate their roles in development and disease in the larval zebrafish model. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - March 3, 2015 Category: Biomedical Science Authors: Otis, J. P., Zeituni, E. M., Thierer, J. H., Anderson, J. L., Brown, A. C., Boehm, E. D., Cerchione, D. M., Ceasrine, A. M., Avraham-Davidi, I., Tempelhof, H., Yaniv, K., Farber, S. A. Tags: Resource Article Source Type: research

Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats [Research Communication]
Intrauterine growth restriction (IUGR) confers heritable alterations in DNA methylation, rendering risk of adult metabolic syndrome (MetS). Because CpG methylation is coupled to intake of essential nutrients along the one-carbon pathway, we reasoned that essential nutrient supplementation (ENS) may abrogate IUGR-conferred multigenerational MetS. Pregnant Sprague-Dawley rats underwent bilateral uterine artery ligation causing IUGR in F1. Among the F2 generation, IUGR lineage rats were underweight at birth (6.7 vs. 8.0 g, P < 0.0001) and obese by adulthood (p160: 613 vs. 510 g; P < 0.0001). Dual energy X-ray absorptiom...
Source: FASEB Journal - March 2, 2015 Category: Biology Authors: Goodspeed, D., Seferovic, M. D., Holland, W., Mcknight, R. A., Summers, S. A., Branch, D. W., Lane, R. H., Aagaard, K. M. Tags: Research Communication Source Type: research

Does metabolic syndrome or its components associate with prostate cancer when diagnosed on biopsy?
Conclusions: We found little evidence to support the hypothesis that increased incidence of metabolic syndrome (or its components) contributes to increased incidence of prostate cancer. A larger, prospective, multicentre investigation is mandatory to confirm if there is any relationship between metabolic syndrome and prostate cancer. (Source: Therapeutic Advances in Medical Oncology)
Source: Therapeutic Advances in Medical Oncology - March 2, 2015 Category: Cancer & Oncology Authors: Telli, O., Sarici, H., Ekici, M., Ozgur, B. C., Doluoglu, O. G., Eroglu, M., Telli, T. A. Tags: Original Research Source Type: research

Greater Healthful Food Variety as Measured by the US Healthy Food Diversity Index Is Associated with Lower Odds of Metabolic Syndrome and its Components in US Adults [Nutritional Epidemiology]
Conclusions: Greater healthful food variety was associated with lower odds of MetS and some MetS components in the total population, NHW adults, and NHB adults. This study provides preliminary evidence that healthful food diversity may protect against MetS and highlights the need for longitudinal and experimental research. (Source: Journal of Nutrition)
Source: Journal of Nutrition - March 2, 2015 Category: Nutrition Authors: Vadiveloo, M., Parkeh, N., Mattei, J. Tags: Nutritional Epidemiology Source Type: research

SU withdrawal from insulin-treated patients
Srivanichakorn W, Sriwijitkamol A, Kongchoo A, Sriussadaporn S, Plengvidhya N, Lertwattanarak R, Vannasaeng S, Thongtang N (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - March 1, 2015 Category: Endocrinology Source Type: research

Early-life physical activity reverses metabolic and Foxo1 epigenetic misregulation induced by gestational sleep disturbance
We report that physical activity during early life, but not later, reversed the increased body weight, altered glucose and lipid homeostasis, and increased visceral adipose tissue in offspring of mice subjected to gestational SF (SFo). The reversibility of this phenotype may reflect epigenetic mechanisms induced by SF during gestation. Accordingly, we found that the metabolic master switch Foxo1 was epigenetically misregulated in SFo livers in a temporally regulated fashion. Temporal Foxo1 analysis and its gluconeogenetic targets revealed that the epigenetic abnormalities of Foxo1 precede the metabolic syndrome phenotype. ...
Source: AJP: Regulatory, Integrative and Comparative Physiology - March 1, 2015 Category: Physiology Authors: Mutskov, V., Khalyfa, A., Wang, Y., Carreras, A., Nobrega, M. A., Gozal, D. Tags: Obesity, Diabetes and Energy Homeostasis Source Type: research

Maternal perinatal undernutrition modifies lactose and serotranferrin in milk: relevance to the programming of metabolic diseases?
A close link between intrauterine growth restriction and development of chronic adult diseases such as obesity, diabetes, and hypertension has been established both in humans and animals. Modification of growth velocity during the early postnatal period (i.e., lactation) may also sensitize to the development of metabolic syndrome in adulthood. This suggests that milk composition may have long-lasting programming/deprogramming metabolic effects in the offspring. We therefore assess the effects of maternal perinatal denutrition on breast milk composition in a food-restricted 50% (FR50) rat model. Monosaccharides and fatty ac...
Source: AJP: Endocrinology and Metabolism - March 1, 2015 Category: Endocrinology Authors: Wattez, J. S., Delmont, A., Bouvet, M., Beseme, O., Goers, S., Delahaye, F., Laborie, C., Lesage, J., Foligne, B., Breton, C., Metges, C. C., Vieau, D., Pinet, F. Tags: Articles Source Type: research

Relationship Between Decayed Teeth and Metabolic Syndrome: Data From 4716 Middle-Aged Male Japanese Employees.
Conclusions: Our findings suggest that having DT is related to MetS in early middle-aged Japanese men directly and through obesity and is independent of health behaviors, periodontal condition, and tooth loss. PMID: 25716056 [PubMed - as supplied by publisher] (Source: Journal of Epidemiology)
Source: Journal of Epidemiology - February 28, 2015 Category: Epidemiology Tags: J Epidemiol Source Type: research

Objective Sleep Structure and Cardiovascular Risk Factors in the General Population: The HypnoLaus Study
Conclusions:In this population-based sample we found significant associations between sleep structure and metabolic syndrome (MS), hypertension, diabetes, and obesity. However, these associations were cancelled after multivariate adjustment. We conclude that normal variations in sleep contribute little if any to MS and associated disorders.Citation:Haba-Rubio J, Marques-Vidal P, Andries D, Tobback N, Preisig M, Vollenweider P, Waeber G, Luca G, Tafti M, Heinzer R. Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus study. SLEEP 2015;38(3):391–400. (Source: Sleep)
Source: Sleep - February 28, 2015 Category: Sleep Medicine Source Type: research

New mechanisms of metformin action: Focusing on mitochondria and the gut
Abstract The most well‐known mechanism of metformin action, one of the most commonly prescribed antidiabetic drugs, is adenosine monophosphate‐activated protein kinase activation; however, recent investigations have shown that adenosine monophosphate‐activated protein kinase‐independent pathways can explain some of metformin's beneficial metabolic effects as well as undesirable side‐effects. Such novel pathways include induction of mitochondrial stress, inhibition of mitochondrial shuttles, alteration of intestinal microbiota, suppression of glucagon signaling, activation of autophagy, attenuation of inflammasome...
Source: Journal of Diabetes Investigation - February 28, 2015 Category: Endocrinology Authors: Kyu Yeon Hur, Myung‐Shik Lee Tags: Review Article Source Type: research

Characterization of Metabolic Syndrome among Diverse Hispanics/Latinos Living in the United States: Latent Class Analysis from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Empirical investigation of the adequacy of metabolic syndrome (MetS) diagnostic criteria, and whether meaningful subtypes of MetS exist, is needed among Hispanics/Latinos. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 28, 2015 Category: Cardiology Authors: William Arguelles, Maria M. Llabre, Ralph L. Sacco, Frank J. Penedo, Mercedes Carnethon, Linda C. Gallo, David J. Lee, Diane J. Catellier, Hector M. González, Christina Holub, Laura R. Loehr, Elsayed Z. Soliman, Neil Schneiderman Source Type: research

Chronic supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet-induced obese rats
Deregulation of miR-33 and miR-122, as major regulators of lipid metabolism in liver, has been related to obesity and metabolic syndrome. Proanthocyanidins repress these miRNAs in healthy animals. Hence, we hypothesized that a chronic consumption of dietary proanthocyanidins can normalize the expression of miR-33a and miR-122. Therefore, the objective of this work was to determine whether the chronic consumption of proanthocyanidins could effectively normalize the expression of miR-33a and miR-122 in rats made obese by a high-fat diet (HFD) and to determine the effective dose. (Source: Nutrition Research)
Source: Nutrition Research - February 28, 2015 Category: Nutrition Authors: Laura Baselga-Escudero, Aïda Pascual-Serrano, Aleix Ribas-Latre, Ester Casanova, M. Josepa Salvadó, Lluís Arola, Anna Arola-Arnal, Cinta Bladé Tags: Original Research Source Type: research

Association of alcohol consumption and components of metabolic syndrome among people in rural China
We examined association of several types of alcoholic beverage with components of MS among people in rural China. Methods: In the Nantong Metabolic Syndrome Study (NMSS), a cross-sectional study, a total of 20,502 participants, including 13,505 women and 6,997 men aged 18–74 years, were recruited between 2007 and 2008 in Nantong, China. Socio-economic status, dietary intake, physical exercise, alcoholic beverage consumption, and smoking status information were obtained, and triglycerides (TG), high-density lipoprtein cholesterol (HDL-c), blood pressure (BP) and blood glucose level were examined for all participants. Logi...
Source: Nutrition and Metabolism - February 28, 2015 Category: Nutrition Authors: Jing XiaoJian HuangGuang XuDe ChenGui WuMin ZhangYi ShenHui Cai Source Type: research

Prevalence of cardio-metabolic syndrome in Nigeria: a systematic review
This is a systematic review of the distribution of cardiometabolic syndrome (CMS) in Nigeria, the clinical definitions widely used and how it affects the proposition of a national prevalence of CMS that will advise management interventions. (Source: Public Health)
Source: Public Health - February 28, 2015 Category: Global & Universal Authors: V.M. Oguoma, E.U. Nwose, R.S. Richards Tags: Review Paper Source Type: research

Relation Between Vitamin D Status and Nonalcoholic Fatty Liver Disease in Children
Conclusions: There is a high prevalence of vitamin D deficiency and insufficiency in children with biopsy-proven NAFLD; however, no association was found between vitamin D deficiency and the severity of disease on biopsies. This differs from adult NAFLD studies in which vitamin D deficiency correlates with histological severity, suggesting differences in the risk factors for or consequences of pediatric NAFLD. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - February 27, 2015 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Musculoskeletal complaints in cardiac rehabilitation: Prevalence and impact on cardiovascular risk factor profile and functional and psychosocial status
Conclusions Musculoskeletal complaints are common in cardiac rehabilitation and predict lower levels of physical activity, worse cardiovascular risk factor profile, and poorer functional capacity and psychosocial status, irrespective of age and gender. (Source: Revista Portuguesa de Cardiologia)
Source: Revista Portuguesa de Cardiologia - February 27, 2015 Category: Cardiology Source Type: research

The role of enteric hormone GLP-2 in the response of bone markers to a mixed meal in postmenopausal women with type 2 diabetes mellitus
Conclusions: Bone turnover markers were significantly reduced in T2D women at baseline. Confirming the role of nutrient intake as a stimulating factor, GLP-2 increased in response to the mixed meal in both groups. Importantly, CTX variation in response to the mixed meal was reduced in T2D women, suggesting abnormal response of bone remodeling to nutrient intake in T2D. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - February 27, 2015 Category: Endocrinology Authors: Laura LopesRubens SchwartzBruno Ferraz-de-SouzaMaria da SilvaPedro CorrêaMárcia Nery Source Type: research

Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome
Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome Kidney International 87, 535 (March 2015). doi:10.1038/ki.2014.351 Authors: Motonobu Nakamura, Osamu Yamazaki, Ayumi Shirai, Shoko Horita, Nobuhiko Satoh, Masashi Suzuki, Yoshifumi Hamasaki, Eisei Noiri, Haruki Kume, Yutaka Enomoto, Yukio Homma & George Seki (Source: Kidney International)
Source: Kidney International - February 27, 2015 Category: Urology & Nephrology Authors: Motonobu NakamuraOsamu YamazakiAyumi ShiraiShoko HoritaNobuhiko SatohMasashi SuzukiYoshifumi HamasakiEisei NoiriHaruki KumeYutaka EnomotoYukio HommaGeorge Seki Tags: insulin resistance IRS1 IRS2 NBCe1 proximal tubule siRNA Source Type: research

The beneficial roles of Lupineus luteus and lifestyle changes in management of metabolic syndrome: A case study
Publication date: Available online 27 February 2015 Source:Saudi Pharmaceutical Journal Author(s): Gamaleldin I. Harisa , Fars K. Alanazi Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including obesity, hypertension, dyslipidemia and hyperuricemia. Here, we report a 43-year-old man with obesity, hypertension, hypercholesterolemia, hyperuricemia and mild liver dysfunctions. Lupid (Lupineus luteus) and therapeutic lifestyle change (TLC) were suggested as therapeutic intervension for the present case for 6 months. The body weight, body mass index (BMI), blood pressure, total cholesterol (TC), low den...
Source: Saudi Pharmaceutical Journal - February 27, 2015 Category: Drugs & Pharmacology Source Type: research

Relationship between high normal TSH levels and metabolic syndrome components in type 2 diabetic subjects with euthyroidism
Conclusion In type 2 diabetic subjects with biochemical euthyroidism we found significant association between high normal TSH levels and components of metabolic syndrome. High normal TSH levels were associated with more number of subjects with glycemic goal (HbA1c &gt;7%). (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - February 27, 2015 Category: Endocrinology Source Type: research

Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome.
Abstract The increasing incidence of the metabolic syndrome (MetS), a combination of risk factors before the onset of CVD and type 2 diabetes, encourages studies on the role of functional food components such as long-chain n-3 PUFA as preventive agents. In the present study, we explore the effect of EPA and DHA supplementation in different proportions on spontaneously hypertensive obese (SHROB) rats, a model for the MetS in a prediabetic state with mild oxidative stress. SHROB rats were randomised into four groups (n 7), each supplemented with EPA/DHA at ratios of 1:1, 2:1 and 1:2, or soyabean oil as the control fo...
Source: The British Journal of Nutrition - February 27, 2015 Category: Nutrition Authors: Molinar-Toribio E, Pérez-Jiménez J, Ramos-Romero S, Romeu M, Giralt M, Taltavull N, Muñoz-Cortes M, Jáuregui O, Méndez L, Medina I, Torres JL Tags: Br J Nutr Source Type: research

The association between cardiovascular risk factors and anthropometric obesity indicators in university students in São Luís in the State of Maranhão, Brazil
O presente artigo tem por objetivo avaliar associação entre fatores de risco cardiovascular (FRCV) e indicadores antropométricos em amostra de base populacional de universitários de São Luís/MA. Estudo transversal com 968 universitários, mediana de 22 anos. Glicemia, triglicerídeos (TGL), HDL-c, tabagismo, consumo de álcool, sedentarismo, síndrome metabólica (SM–critérios do Joint Interim Statement) e resistência insulínica (RI), foram associados e correlacionados com os indicadores antropométricos Índice de Massa Corporal (IMC), Circunferência da Cintura (CC), Relação Cintura Quadril (RCQ) e Relação...
Source: Ciencia e Saude Coletiva - February 26, 2015 Category: Occupational Health Source Type: research

Quantitative relationship between liver fat content and metabolic syndrome in obese children and adolescents
ConclusionsIn obese Chinese pediatric patients, quantitative measures of LFC are positively associated with the risk of MetS, hypertriglyceridemia, and low high‐density lipoprotein cholesterol, independent of traditional risk factors. These findings suggest that quantitatively measured LFC may be a clinically useful marker for identifying obese pediatric who are at increased risk of developing MetS and its components.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 26, 2015 Category: Endocrinology Authors: Hongxi Zhang, Huiping Yang, Can Lai, Xiaoqin Xu, Ke Huang, Junfen Fu Tags: Original Article Source Type: research

Surgical menopause versus natural menopause and cardio-metabolic disturbances: A 12-year population-based cohort study
Conclusions Metabolic disturbances after menopause are highly influenced by type of menopause and are more prevalent in those undergoing surgical menopause. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 26, 2015 Category: Endocrinology Source Type: research

Dietary pattern and metabolic syndrome in thai adults.
Conclusion. The carbohydrate pattern with low level of LTPA increased the odds of MetS. PMID: 25699190 [PubMed] (Source: Journal of Nutrition and Metabolism)
Source: Journal of Nutrition and Metabolism - February 26, 2015 Category: Nutrition Tags: J Nutr Metab Source Type: research

Common variant within the FTO gene, rs9939609, obesity and type 2 diabetes in population of Karachi, Pakistan
Conclusion In the study population of South Asian ancestry, variants of the FTO gene predispose to type 2 diabetes, but not entirely through their effect on BMI. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - February 26, 2015 Category: Endocrinology Source Type: research

Global Epidemiology
Liver cancer is the second leading cause of global cancer mortality. The major risk factors for hepatocellular carcinoma (HCC) are being addressed with success by prevention efforts. Vaccination against hepatitis B virus has reduced incidence of HCC in Taiwan and is partly responsible for lower rates in China. New infections with hepatitis C virus are low in developed countries because of prevention of posttransfusion infections and reduced exposure to HCV by drug users. Aflatoxin exposure has been reduced by better grain storage and dietary changes. Obesity, metabolic syndrome, and diabetes are increasing in developed and...
Source: Clinics in Liver Disease - February 26, 2015 Category: Gastroenterology Authors: Katherine A. McGlynn, Jessica L. Petrick, W. Thomas London Source Type: research

Cyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia
Folic acid supplementation is the mainstay treatment of hyperhomocysteinemia (HHcy). However, no recommendations are currently available in regards to the optimal replacement therapy. Therefore, this prospective study hypothesized that a cyclic schedule (one month of therapy followed by two months of withdrawal) of 5-Methyl-Tetra-Hydro-Folate (5-MTHF) would reduce plasma levels of fasting total homocysteine (tHcy) in patients with mild/moderate HHcy. Patients with a new diagnosis of mild/moderate HHcy were evaluated for the Methylene-Tetra-Hydro-Folate Reductase (MTHFR) genotype and the presence of major features of metabo...
Source: Nutrition Research - February 26, 2015 Category: Nutrition Authors: Pasquale Ambrosino, Roberta Lupoli, Alessandro Di Minno, Assunta Nardo, Emiliana Marrone, Valentina Lupoli, Alessandra Scaravilli, Emma Mitidieri, Antonella Tufano, Matteo Nicola Dario Di Minno Source Type: research

Urinary tract infection and diabetes mellitus
Nitzan O, Elias M, Chazan B, Saliba W, (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - February 25, 2015 Category: Endocrinology Source Type: research

Sotagliflozin in NOD mice with type 1 diabetes
Powell DR, Doree D, Jeter-Jones S, Ding ZM, Zambrowicz B, Sands A (Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - February 25, 2015 Category: Endocrinology Source Type: research

Emerging role of microRNAs in lipid metabolism
Publication date: Available online 24 February 2015 Source:Acta Pharmaceutica Sinica B Author(s): Zhihong Yang , Tyler Cappello , Li Wang microRNAs (miRNAs or miRs) are small non-coding RNAs that are involved in post-transcriptional regulation of their target genes in a sequence-specific manner. Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis, fatty acid oxidation and lipoprotein formation and secretion. Dysregulation of miRNAs disrupts gene regulatory network, leading to metabolic syndrome and its related diseases. In this review, we introduced epigenetic and transcriptional regulat...
Source: Acta Pharmaceutica Sinica B - February 25, 2015 Category: Cancer & Oncology Source Type: research

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Nature advance online publication 25 February 2015. doi:10.1038/nature14232 Authors: Benoit Chassaing, Omry Koren, Julia K. Goodrich, Angela C. Poole, Shanthi Srinivasan, Ruth E. Ley & Andrew T. Gewirtz The intestinal tract is inhabited by a large and diverse community of microbes collectively referred to as the gut microbiota. While the gut microbiota provides important benefits to its host, especially in metabolism and immune development, disturbance of the microbiota–host relationship is associated with numerous chronic inflammatory diseases, including inflammatory bowel disease and the group of obesity-assoc...
Source: Nature AOP - February 25, 2015 Category: Research Authors: Benoit ChassaingOmry KorenJulia K. GoodrichAngela C. PooleShanthi SrinivasanRuth E. LeyAndrew T. Gewirtz Tags: Letter Source Type: research

Predictors of metabolic syndrome persistence one year after laparoscopic Roux-en-Y gastric bypass
Laparoscopic Roux-en-Y gastric bypass (LRYGB) is effective in reversing the metabolic syndrome (MS) in up to 90% of patients. The aim of this study was to determine predictors of MS persistence 1 year after LRYGB. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - February 25, 2015 Category: Surgery Authors: Francesco Martini, Rodolphe Anty, Anne-Sophie Schneck, Vincent Casanova, Antonio Iannelli, Jean Gugenheim Tags: Original articles Source Type: research

Maternal fructose intake-induced renal programming in adult male offspring
We examined potential key genes and pathways that are associated with HF-induced renal programming using whole-genome RNA next-generation sequencing (NGS) to quantify the abundance of RNA transcripts in kidneys from 1 day, 3 week, and 3 month old male offspring. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - February 25, 2015 Category: Biochemistry Authors: You-Lin Tain, Kay L.H. Wu, Wei-Chia Lee, Steve Leu, Julie Y.H. Chan Source Type: research

Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids
The widespread acceptance that increased dietary n-3 polyunsaturated fatty acids (PUFA), especially α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), improve health is based on extensive studies in animals, isolated cells, and humans. Visceral adiposity is part of the metabolic syndrome, together with insulin resistance, dyslipidemia, hypertension, and inflammation. Alleviation of metabolic syndrome requires normalization of insulin release and responses. This review assesses our current knowledge of the mechanisms that allow n-3 PUFA to improve insulin secretion and sensitivity. (Source...
Source: The Journal of Nutritional Biochemistry - February 25, 2015 Category: Biochemistry Authors: Maharshi Bhaswant, Hemant Poudyal, Lindsay Brown Source Type: research

Prolactin anterior pituitary expression and circulating levels are reduced in obese and diabetic rats: Role of TGFβ and TNFα
Abstract The levels of the hormone prolactin (PRL) are reduced in the circulation of patients with type 2 diabetes and in obese children, and lower systemic PRL levels correlate with an increased prevalence of diabetes and a higher risk of metabolic syndrome. The secretion of anterior pituitary (AP) PRL in metabolic diseases may be influenced by the interplay between transforming growth factor β (TGFβ) and tumor necrosis factor α (TNFα), which inhibit and can stimulate AP PRL synthesis, respectively, and are known contributors to insulin resistance and metabolic complications. Here, we show that TGFβ and TNFα...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 25, 2015 Category: Physiology Authors: Lemini M, Ruiz-Herrera X, Ledesma-Colunga MG, Díaz-Lezama N, De Los Ríos EA, Lopez-Barrera F, Méndez I, Martinez de la Escalera G, Macotela Y, Clapp C Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Cardiovascular mortality in patients with prostate cancer exposed to androgen deprivation therapy.
CONCLUSIONS: Patients with AMC or congestive heart failure history could present a higher risk of death related to the use of GnRH agonists. In these cases, should carefully consider appropriateness of such treatment. These effects can explained by a direct mechanism on myocardium and peripheral vascular tree and indirect ones related with modified metabolic syndrome. PMID: 25726508 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - February 25, 2015 Category: Urology & Nephrology Authors: Monzó-Gardiner JI, Herranz-Amo F Tags: Actas Urol Esp Source Type: research

Prevalence and risk factors for biopsy‐proven NAFLD and NASH in a prospective cohort of adult patients with gallstones
ConclusionsPrevalence of NASH among patients with gallstones is lower than estimated previously, but NASH is frequent particularly in those patients with concurrent metabolic syndrome. The combination of an increased HOMA score with fatty liver on ultrasound has a good accuracy for predicting NASH in patients with gallstones.This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - February 24, 2015 Category: Gastroenterology Authors: Carmelo García‐Monzón, Javier Vargas‐Castrillón, José Luís Porrero, María Teresa Alonso, Oscar Bonachía, María José Castillo, Alberto Marcos, Esther Quirós, Beatriz Ramos, Carlos Sánchez‐Cabezudo, Sol Villar, Alicia Sáez, Javier Rodrígu Tags: Original Article Source Type: research

Metabolic syndrome and risk of age-related macular degeneration
Conclusion: Metabolic syndrome, obesity, high glucose, and high triglycerides were predictors of progression to late AMD. These data provide additional insights into the pathogenesis of AMD. (Source: RETINA)
Source: RETINA - February 24, 2015 Category: Opthalmology Tags: Original Study Source Type: research

Epigenomics, gestational programming and risk of metabolic syndrome
M G Ross (Source: International Journal of Obesity)
Source: International Journal of Obesity - February 24, 2015 Category: Eating Disorders and Weight Management Authors: M DesaiJ K JellymanM G Ross Source Type: research

Darwinian Medicine and Psoriasis
Publication date: Available online 24 February 2015 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): J. Romaní de Gabriel Darwinian medicine, or evolutionary medicine, regards some pathological conditions as attempts by the organism to solve a problem or develop defense mechanisms. At certain stages of human evolution, some diseases may have conferred a selective advantage. Psoriasis is a high-penetrance multigenic disorder with prevalence among whites of up to 3%. Psoriatic lesions have been linked with enhanced wound-healing qualities and greater capacity to fight infection. Leprosy, tuberculosis, and ...
Source: Actas Dermo-Sifiliograficas - February 24, 2015 Category: Dermatology Source Type: research

Effects of Roux-en-Y gastric bypass on fasting and postprandial inflammation-related parameters in obese subjects with normal glucose tolerance and in obese subjects with type 2 diabetes
Conclusions: One year after RYGB, fasting concentrations of IL-6 and leptin were reduced, while no changes were observed in IL-8. TGF-β was decreased and adiponectin increased in both T2D and NGT obese subjects. This study is the first to examine IL-8 and TGF-β in obese subject after RYGB. Resolution of inflammation could offer a potential explanation for the health improvement associated with major weight loss after bariatric surgery.Trial registrationClinicalTrials.gov ID NCT01579981 (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - February 24, 2015 Category: Endocrinology Authors: Kirsten LindegaardNils JorgensenRasmus JustPeter HeegaardSten Madsbad Source Type: research

High serum ferritin level is an independent risk factor for metabolic syndrome in a Chinese male cohort population
We examined the association of serum ferritin levels with the development of MetS in a representative sample of Chinese male adult population.MethodThe data came from the 2009–2013 Fangchenggang Area Males Health and Examination Survey (FAMHES). We combined a cross-sectional study of 2417 males and a longitudinal study of 857 males who participated in the FAMHES.ResultThe serum ferritin level of MetS was higher than that of nonMetS (median and percentiles 25–75: 447.4 (294.1-612.4) vs. 302.4 (215.0-435.8) ng/ ml, p  (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - February 24, 2015 Category: Endocrinology Authors: Qin TangZhenfang LiuYan TangAihua TanYong GaoZheng LuQiuyan WangYingchun ChenChunlei WuHaiying ZhangXiaobo YangZengnan Mo Source Type: research