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Gene Therapy for Hemophilia B with liver-specific element mediated by Rep-RBE site-specific integration system.
In this study, we established a novel hFIX expression plasmid, pRBE-HCR-hAAT-hFIX, driven by a liver specific promoter by replacing the CMV promoter of pRBE-CMV-hFIX with a humanized promoter consisting of HCR-hAAT. The expression of hFIX in vitro was almost the same in transient transfection of pRBE-CMV-hFIX or pRBE-HCR-hAAT-hFIX. AAVS1 specific integrations were identified both in mice transfected with pRC /pRBE-CMV-hFIX cocktail and pRC/ pRBE-HCR-hAAT-hFIX cocktail. However, the expression of hFIX of pRBE-HCR-hAAT-hFIX mice was higher and persisted longer. It achieved more than 1% of normal plasma hFIX concentration and...
Source: Pharmacological Reports - October 7, 2014 Category: Drugs & Pharmacology Authors: Xu Z, Ye J, Zhang A, Xie L, Shen Q, Xue J, Chen J Tags: J Cardiovasc Pharmacol Source Type: research

Phenylbutazone and ketoprofen binding to serum albumin. Fluorescence study.
CONCLUSIONS: The conclusion, that both PBZ and KP form a binding site in the same subdomains (IIA or/and IB), points to the necessity of using a monitoring therapy owning to the possible increase of the uncontrolled toxic effects. PMID: 25149974 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Maciążek-Jurczyk M Tags: Pharmacol Rep Source Type: research

The effect of resveratrol and its methylthio-derivatives on NF-κB and AP-1 signaling pathways in HaCaT keratinocytes.
CONCLUSIONS: We conclude that methylthiostilbenes differently modulate constitutive signal transduction pathways in HaCaT cells. These observations should be taken into account in designing new stilbene derivatives with potential chemopreventive activity. PMID: 25149975 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Szaefer H, Cichocki M, Krajka-Kuźniak V, Stefański T, Sobiak S, Licznerska B, Baer-Dubowska W Tags: Pharmacol Rep Source Type: research

Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases.
CONCLUSION: Our results show a potent anti-inflammatory and antinociceptive effect of P-317 in mouse models of colitis upon activation of opioid receptors. The unique bioavailability of P-317 after oral administration suggests that it is a promising drug candidate for future treatment of IBD. PMID: 25149976 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Sobczak M, Zakrzewski PK, Cygankiewicz AI, Mokrowiecka A, Chen C, Sałaga M, Małecka-Panas E, Kordek R, Krajewska WM, Fichna J Tags: Pharmacol Rep Source Type: research

Exogenous hydrogen sulfide causes different hemodynamic effects in normotensive and hypertensive rats via neurogenic mechanisms.
CONCLUSIONS: The results provide further evidence for the involvement of H2S in the neurogenic regulation of the circulatory system and suggest that alterations in H2S signaling in the brain could be associated with hypertension. PMID: 25149977 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Sikora M, Drapala A, Ufnal M Tags: Pharmacol Rep Source Type: research

Comparison of chosen activation markers of human monocytes/macrophages isolated from the peripheral blood of young and elderly volunteers.
CONCLUSIONS: The changes observed in the macrophages isolated from the elderly indicate that these cells could contribute to the development of metabolic disorders like atherosclerosis and diabetes. The cells from the young volunteers are less likely to present such properties. PMID: 25149978 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Suchy D, Labuzek K, Bułdak L, Szkudłapski D, Okopień B Tags: Pharmacol Rep Source Type: research

Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases.
Abstract Inflammatory bowel diseases (IBD) are chronic, relapsing disorders affecting gastrointestinal (GI) tract and associated with intestinal mucosa damage and inflammation. The principal therapeutic goals in IBD include control of the intestinal inflammation and treatment of the major symptoms, mainly abdominal pain and diarrhea. Current therapeutic strategies for IBD rely on the use of non-specific anti-inflammatory agents and immunosuppressive drugs (e.g. aminosalicylates, monoclonal antibodies, and antibiotics), which cause severe side effects, and - in a significant number of patients - do not induce long-t...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Sobczak M, Fabisiak A, Murawska N, Wesołowska E, Wierzbicka P, Wlazłowski M, Wójcikowska M, Zatorski H, Zwolińska M, Fichna J Tags: Pharmacol Rep Source Type: research

The role of the neuroendocrine and immune systems in the pathogenesis of depression.
This article illustrates the involvement of key mediators of allostasis such as the neuroendocrine and immune systems, in the pathogenesis of depression. The literature concerning the contribution of the neuroendocrine and immune systems to depression incidence was reviewed. Development of depression is associated with disturbance of the body's allostasis and inflammatory activation of the immune system. It leads to a chronic increase in the concentration of cortisol and proinflammatory cytokines, which results in an allostatic load. This load leads to neurodegeneration, eventually causing irreversible cognitive impairment...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Ogłodek E, Szota A, Just M, Moś D, Araszkiewicz A Tags: Pharmacol Rep Source Type: research

Curcumin influences semen quality parameters and reverses the di(2-ethylhexyl)phthalate (DEHP)-induced testicular damage in mice.
CONCLUSION: The effects of curcumin were dependent on its concentration. In male germ cells in vivo the protective effect was seen despite the low bioavailability of curcumin. In contrast, high, unattainable in the organism, concentration of curcumin had a cytotoxic effect on male reproductive cells in vitro. Curcumin also had a protective effect against the harmful impact of DEHP on the male reproductive system. PMID: 25149981 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Głombik K, Basta-Kaim A, Sikora-Polaczek M, Kubera M, Starowicz G, Styrna J Tags: Pharmacol Rep Source Type: research

Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells.
CONCLUSIONS: Incorporating the phytosomal form of silymarin in liposomal carrier system increased the oral bioavailability and showed better hepatoprotection and better anti-inflammatory effects compared with silymarin suspension. PMID: 25149982 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Kumar N, Rai A, Reddy ND, Raj PV, Jain P, Deshpande P, Mathew G, Kutty NG, Udupa N, Rao CM Tags: Pharmacol Rep Source Type: research

Therapeutic potential of resveratrol in diabetic complications: In vitro and in vivo studies.
CONCLUSIONS: The results obtained in this study underline the potential of RSV as a possible therapeutic agent against long-term diabetic complications. PMID: 25149983 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Ciddi V, Dodda D Tags: Pharmacol Rep Source Type: research

Neuropharmacological effect of novel 5-HT3 receptor antagonist, N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n) on chronic unpredictable mild stress-induced molecular and cellular response: Behavioural and biochemical evidences.
CONCLUSION: Compound 6n produced antidepressant-like effects in behavioural despair paradigm in chronically stressed mice by restoring antioxidant enzyme activity up to significant level. PMID: 25149984 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Bhatt S, Mahesh R, Jindal A, Devadoss T Tags: Pharmacol Rep Source Type: research

The latest achievements in the pharmacotherapy of gambling disorder.
Abstract Gambling disorder (GD) is becoming increasingly prevalent both among adults and adolescents. Unfortunately, this disorder is largely underestimated, while it can still lead to serious social and personal consequences, including criminal behavior or suicide attempts. In the past, the only means of treating gambling were psychobehavioral therapies. Nowadays, this disorder could also respond to many drugs from different classes such as opioid antagonists, serotonin selective reuptake inhibitors, mood stabilizers, atypical antipsychotics or glutamatergic agents. This review presents current pharmacological str...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Labuzek K, Beil S, Beil-Gawełczyk J, Gabryel B, Franik G, Okopień B Tags: Pharmacol Rep Source Type: research

Pharmacokinetics and pharmacodynamics of propofol in children undergoing different types of surgeries.
CONCLUSIONS: The BIS values in children are highly correlated with the propofol effect compartment concentrations according to the classical Emax concentration-response relationship. Children had slightly lower sensitivity to propofol and slightly higher clearance, as compared with the adult data available in literature. The intra-patient variations in the BIS require the anesthesiologist's attention in using BIS values alone to evaluate the depth of anesthesia in children. PMID: 25149986 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Bartkowska-Śniatkowska A, Bienert A, Wiczling P, Owczarek M, Rosada-Kurasińska J, Grześkowiak M, Matysiak J, Kokot ZJ, Kaliszan R, Grześkowiak E Tags: Pharmacol Rep Source Type: research

Neuroligins, synapse balance and neuropsychiatric disorders.
Abstract Neuroligins are postsynaptic adhesion molecules that are involved in the regulation of synapse organisation and function. Four neuroligin proteins have been identified (neuroligin 1, 2, 3, 4), which are differentially enriched in the postsynaptic specialisation of synapses. Neuroligin 1 is localised on excitatory (glutamatergic) synapses, whereas neuroligin 2 is located on inhibitory (GABAergic/glycinergic) synapses. Neuroligin 3 and 4 are present on both types of synapses. Recent data indicate that neuroligins are involved in synapse maturation and specification. Because of their synaptic localisation and...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Maćkowiak M, Mordalska P, Wędzony K Tags: Pharmacol Rep Source Type: research

TNF inhibitors - Mechanisms of action, approved and off-label indications.
Abstract Tumor necrosis factor inhibitors (TNFi) belong to the group of biologic drugs, holding presently top positions on lists of most profitable products for pharmaceutical companies. Although current indications for TNFi include only selected diseases with an established role of immune dysfunction in their pathogenesis, studies on new indications are being carried out all over the world. The most important aspect of TNFi therapy is a targeted therapeutic approach, allowing to avoid a wide range of side effects associated with treatment with nonspecific immunosuppressive agents. Results of the trials on TNFi in ...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Cessak G, Kuzawińska O, Burda A, Lis K, Wojnar M, Mirowska-Guzel D, Bałkowiec-Iskra E Tags: Pharmacol Rep Source Type: research

Inhibition of intracellular signaling pathways NF-κB and MEK1/2 attenuates neuropathic pain development and enhances morphine analgesia.
CONCLUSIONS: These results indicate that the inhibition of the NF-κB pathway has better analgesic effects. Both inhibitors similarly potentiate morphine analgesia, which parallels the up-regulation of both mor and dor mRNAs expression spinal levels of the model of neuropathy. PMID: 25149989 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Popiolek-Barczyk K, Makuch W, Rojewska E, Pilat D, Mika J Tags: Pharmacol Rep Source Type: research

Vague effects of chronic topiramate administration on maximal electroshock-induced seizures in mice.
CONCLUSIONS: Maximal electroshock in mice does not seem to be an appropriate seizure model to test anticonvulsant effects of chronic topiramate. PMID: 25149990 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Banach M, Szpot P, Buszewicz G, Borowicz KK Tags: Pharmacol Rep Source Type: research

Vascular effects of a tripeptide fragment of novokinine in hypertensive rats: Mechanism of the hypotensive action.
CONCLUSIONS: LKP lowered MAP in norepinephrine-induced hypertension, probably via activation of AT2R. At reduced availability of AT2R, as in SHR, LKP appeared to bind to different receptors, possibly AT1, and induced systemic or renal vasoconstriction. Compared to the parent novokinine, a smaller LKP molecule might be easier absorbed after oral application and more useful in therapy. PMID: 25149991 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Bądzyńska B, Lipkowski AW, Sadowski J, Kompanowska-Jezierska E Tags: Pharmacol Rep Source Type: research

Chronic treatment with zinc hydroaspartate induces anti-inflammatory and anti-ulcerogenic activity in rats.
CONCLUSIONS: The present study demonstrated for the first time that chronic treatment with zinc salt exhibits anti-inflammatory activity. Besides, anti-ulcerogenic activity and the enhancing properties of zinc to ketoprofen induced anti-inflammatory and analgesic activity were also shown. PMID: 25149992 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Gaweł M, Lipkowska A, Herman M, Golasik M, Piekoszewski W, Gomolka E, Schlegel-Zawadzka M, Opoka W, Nowak G, Librowski T Tags: Pharmacol Rep Source Type: research

mRNA of cytokines in bone marrow and bone biomarkers in response to propranolol in a nutritional growth retardation model.
CONCLUSIONS: This study provides evidences that NGR outcomes in a bone marrow proinflammatory microenvironment leading to unbalanced bone remodeling by enhancement of bone resorption reverted by propranolol. PMID: 25149993 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Tasat DR, Lezón CE, Astort F, Pintos PM, Macri EV, Friedman SM, Boyer PM Tags: Pharmacol Rep Source Type: research

Vagotomy reveals the importance of the imidazoline receptors in the cardiovascular effects of marsanidine and 7-ME-marsanidine in rats.
CONCLUSION: The results show that although cardiovascular effects of marsanidine and 7-Me-marsanidine are not mediated by the vagal nerves, vagotomy enhanced sensitivity of the sympathetic pathways for the tested compounds. While the action of marsanidine in vagotomised and intact rats may be explained by activation of the α2 adrenoreceptors, the effects of 7-Me-marsanidine seem to be α2 adrenoreceptor-independent. It seems likely that activation of I1 imidazoline receptors could mediate the observed effects. PMID: 25149994 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Boblewski K, Lehmann A, Sączewski F, Kornicka A, Rybczyńska A Tags: Pharmacol Rep Source Type: research

The effect of short-term simvastatin treatment on plasma adipokine levels in patients with isolated hypercholesterolemia: A preliminary report.
CONCLUSIONS: Our results indicate that the presence of isolated hypercholesterolemia is associated with abnormal hormonal function of the adipose tissue. These changes are partially reversed by short-term simvastatin treatment, and this action may contribute to the clinical effectiveness of statins in the therapy of atherosclerosis-related disorders. PMID: 25149995 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Krysiak R, Zmuda W, Okopień B Tags: Pharmacol Rep Source Type: research

Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice.
CONCLUSION: These data suggest that the piperine produced significant anxiolytic activity in unstressed mice possibly through increase in GABA levels and inhibition of neuronal NOS. On the other hand, antianxiety activity in stressed mice might be through inhibition of inducible NOS. PMID: 25149996 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Gilhotra N, Dhingra D Tags: Pharmacol Rep Source Type: research

The pharmacokinetics and hypoglycaemic effect of sunitinib in the diabetic rabbits.
CONCLUSIONS: The research proved the significant influence of diabetes on the pharmacokinetics of sunitinib and it confirmed the hypoglycaemic effect of the TKI in diabetic rabbits and in normoglycaemia. PMID: 25149997 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Szałek E, Karbownik A, Sobańska K, Grabowski T, Połom W, Lewandowska M, Wolc A, Matuszewski M, Grześkowiak E Tags: Pharmacol Rep Source Type: research

Propargylglycine aggravates liver damage in LPS-treated rats: Possible relation of nitrosative stress with the inhibition of H2S formation.
CONCLUSION: These findings support the view that the suppression of nitrosative stress by endogenous H2S is one of the mechanisms to protect liver against endotoxemic injury. PMID: 25149998 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Bekpinar S, Unlucerci Y, Uysal M, Gurdol F Tags: Pharmacol Rep Source Type: research

Association between chemotherapy and plasma adipokines in patients with colorectal cancer.
CONCLUSIONS: The results of the present study are relevant because we found that chemotherapy in colorectal cancer patients, in addition to its beneficial clinical impact on the course of disease, positively affects cytokine production and release (increases the anti-inflammatory adiponectin and decreases visfatin and resistin, which are proangiogenic and promote cancer cell proliferation). The restoration of adequate adipose tissue function is essential for patients to achieve a good survival prognosis. PMID: 25149999 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Słomian G, Swiętochowska E, Malinowska-Borowska J, Kasperczyk S, Rogalska A, Nowak P Tags: Pharmacol Rep Source Type: research

Pharmacokinetics of phosphocreatine and its active metabolite creatine in the mouse plasma and myocardium.
CONCLUSION: The PCr in plasma is converted to Cr rapidly and mostly, and shows an elimination rate limited (ERL) metabolite disposition. Iv PCr caused a significantly elevated and long-lasing myocardial ATP and Cr levels. The Pit-induced myocardial ischemia brings slower elimination of PCr and Cr and higher peak concentrations of Cr and ATP in myocardium. The metabolite Cr at least partially mediates PCr-caused rise in myocardial ATP level and also possibly the cardio-protective effects of PCr. PMID: 25150000 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Xu L, Wang CY, Lv L, Liu KX, Sun HJ, Han GZ Tags: Pharmacol Rep Source Type: research

Recombinant human interleukin 24 reverses Adriamycin resistance in a human breast cancer cell line.
CONCLUSIONS: rhIL-24 circumvented the drug-resistance of MCF-7/ADM cells via activation of the transcription factor Stat 3. rhIl24 has potential to act as a P-gp inhibitor to reverse Adriamycin resistance in breast cancer. PMID: 25150001 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Amirzada MI, Ma X, Gong X, Chen Y, Bashir S, Jin J Tags: Pharmacol Rep Source Type: research

Comparison of chemokines (CCL-5 and SDF-1), chemokine receptors (CCR-5 and CXCR-4) and IL-6 levels in patients with different severities of depression.
CONCLUSIONS: The results of this study indicate the need for assessment of CCL-5 and SDF-1 chemokines levels, as they are likely markers of developing depression. Early measurement of these chemokines levels may be helpful in choosing the best pharmacotherapy. PMID: 25150002 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Ogłodek EA, Szota A, Just MJ, Moś D, Araszkiewicz A Tags: Pharmacol Rep Source Type: research

Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP.
Abstract Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals. Our results may qualify antagonists of mGluR5 as potential antiepil...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Zavala-Tecuapetla C, Kubová H, Otáhal J, Tsenov G, Mareš P Tags: Pharmacol Rep Source Type: research

Statins - Are they anticonvulsant?
Abstract Statins are the most popular and effective lipid-lowering medications beneficial in hypercholesterolemias and prevention of cardiovascular diseases. Growing evidence supports theory that statins exhibit neuroprotective action in acute stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis or epilepsy. Hereby, we present available experimental data regarding action of this group of drugs on seizure activity and neuronal cell death. The most commonly examined statins, such as atorvastatin and simvastatin, display anticonvulsant action with only inconsiderable exceptions. However, the mechanism ...
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Banach M, Czuczwar SJ, Borowicz KK Tags: Pharmacol Rep Source Type: research

Vitamin C: A new auxiliary treatment of epilepsy?
Abstract Although many approaches to the therapy of epilepsy exist, most of antiepileptic drugs, beside certain and unquestioned benefits, have convinced disadvantages. That is the reason for looking for new methods of treatment. Ascorbic acid, as an antioxidant and electron donor accumulated in central nervous system, seems to take part in diminishing reactions of oxidative stress in brain and cooperate with other antioxidants like alpha-tocoferol. Vitamin C, easily transported through the blood-brain barrier, is proved to reduce injury in the hippocampus during seizures. Depending on type of seizures, it has most...
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Sawicka-Glazer E, Czuczwar SJ Tags: Pharmacol Rep Source Type: research

Essential elements in depression and anxiety. Part I.
Abstract Essential elements are very important for the proper functioning of the human body. They are required for fundamental life processes such as cell division and differentiation and protein synthesis. Thus a deficiency of these essential elements is associated with an enormous health risk that can ultimately lead to death. In recent years, studies have provided valuable information on the involvement of essential elements in psychiatric disorders, in particular depression and anxiety. There is strong evidence indicating that deficiency of essential elements can lead to the development of depressive and/or anx...
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Młyniec K, Davies CL, de Agüero Sánchez IG, Pytka K, Budziszewska B, Nowak G Tags: Pharmacol Rep Source Type: research

Antiarrhythmic drugs and epilepsy.
Abstract For a long time it has been suspected that epilepsy and cardiac arrhythmia may have common molecular background. Furthermore, seizures can affect function of the central autonomic control centers leading to short- and long-term alterations of cardiac rhythm. Sudden unexpected death in epilepsy (SUDEP) has most likely a cardiac mechanism. Common elements of pathogenesis create a basis for the assumption that antiarrhythmic drugs (AADs) may affect seizure phenomena and interact with antiepileptic drugs (AEDs). Numerous studies have demonstrated anticonvulsant effects of AADs. Among class I AADs (sodium chann...
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Borowicz KK, Banach M Tags: Pharmacol Rep Source Type: research

The current approach into signaling pathways in pulmonary arterial hypertension and their implication in novel therapeutic strategies.
Abstract Many mediators and signaling pathways, with their downstream effectors, have been implicated in the pathogenesis of pulmonary hypertension. Currently approved drugs, representing an option of specific therapy, target NO, prostacyclin or ET-1 pathways and provide a significant improvement in the symptomatic status of patients and a slower rate of clinical deterioration. However, despite such improvements in the treatment, PAH remains a chronic disease without a cure, the mortality associated with PAH remains high and effective therapeutic regimens are still required. Knowledge about the role of the pathways...
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Jasińska-Stroschein M, Orszulak-Michalak D Tags: Pharmacol Rep Source Type: research

Evaluation of the clinical indications, adverse drug reactions, and finasteride use in patients with benign prostatic hyperplasia in Poland.
CONCLUSION: Finasteride was demonstrated to be effective, as evidenced by the significant decrease in TPV by 40% even after 12 months. It was also found to contribute to the attenuation of LUTSs, improvement in maximum flow rate, decrease in nocturia, and improvement in QoL. PMID: 24948055 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Ząbkowski T Tags: Pharmacol Rep Source Type: research

Epicutaneous immunization with phosphorylcholine conjugated to bovine serum albumin (PC-BSA) and TLR9 ligand CpG alleviates pneumococcal pneumonia in mice.
CONCLUSION: This work shows that EC immunization with PC-BSA plus TLR9 ligand CpG may be a potential tool to boost immunity to S. pneumoniae. PMID: 24948056 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Majewska-Szczepanik M, Yamamoto N, Askenase PW, Szczepanik M Tags: Pharmacol Rep Source Type: research

Protection of differentiated neuronal NG108-15 cells from P2X7 receptor-mediated toxicity by taurine.
CONCLUSIONS: The neuroprotective effect by taurine is attributed to the suppression of P2X7R-mediated ER stress and ROS formation. PMID: 24948057 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Chao CC, Chan P, Kuo CS, Gong CL, Cheng TH, Liu ZM, Shen PC, Huang CC, Leung YM Tags: Pharmacol Rep Source Type: research

Development of an alternative non-obese non-genetic rat model of type 2 diabetes using caffeine and streptozotocin.
CONCLUSION: The data of food and fluid intake, body weight, blood glucose, glucose tolerance test, HOMA-IR, HOMA-beta, serum insulin, fructosamine, lipid profile and organ specific enzymes, anti-diabetic drug response tests, and pancreatic histopathology suggest that CAF20 group can be a better alternative non-genetic model of non-obese T2D. PMID: 24948058 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Naidoo P, Islam MS Tags: Pharmacol Rep Source Type: research

Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa.
CONCLUSION: Combination treatments confer synergistic protective effect against peptic ulcer in rats, which was related to the gastroprotective, antisecratory and antioxidant activity of combination treatment. Results proved that use of gallic acid with existing antiulcer drug will be more useful in the prevention/management of peptic ulcer. PMID: 24948059 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Asokkumar K, Sen S, Umamaheswari M, Sivashanmugam AT, Subhadradevi V Tags: Pharmacol Rep Source Type: research

Antinociceptive effect of d-Lys(2), Dab(4)N-(ureidoethyl)amide, a new cyclic 1-4 dermorphin/deltorphin analog.
CONCLUSIONS: Systemic application of cUP-1 elicited a dose-dependent antinociceptive effect. The analgesic efficacy of cUP-1 on mechanical nociception, visceral and formalin-induced pain was comparable to that of MF. cUP-1 did not impair motor functions of mice. PMID: 24948060 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Antkowiak B, Paluch M, Ciechanowska M, Nawrocka M, Bańkowski K, Michalak O, Kocik J, Kowalczyk M, Izdebski J Tags: Pharmacol Rep Source Type: research

Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice.
CONCLUSIONS: The study revealed that trimethylgallic acid esters could ameliorate chronic stress-induced various behavioral and biochemical alterations in mice, showing protective effects against chronic stress. PMID: 24948061 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Dhingra MS, Dhingra S, Kumria R, Chadha R, Singh T, Kumar A, Karan M Tags: Pharmacol Rep Source Type: research

The prevalence of antipsychotic polypharmacy in schizophrenic patients discharged from psychiatric units in Poland.
CONCLUSIONS: The prevalence of polypharmacy in Poland is similar to that reported in other countries. This may suggest that, in a substantial proportion of schizophrenic patients clinical response to the antipsychotic monotherapy is unsatisfactory. Further studies focusing on the efficacy and safety of strategies in the treatment of patients with schizophrenia not responding to antipsychotic monotherapy are necessary. PMID: 24948062 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Jaracz J, Tetera-Rudnicka E, Kujath D, Raczyńska A, Stoszek S, Czernaś W, Wierzbiński P, Moniakowski A, Jaracz K, Rybakowski J Tags: Pharmacol Rep Source Type: research

Metrifonate, like acetylcholine, up-regulates neurotrophic activity of cultured rat astrocytes.
CONCLUSIONS: Metrifonate up-regulates astrocytic NGF and BDNF synthesis in the same manner as acetylcholine, their effect depends on different cholinergic pathways. These results suggest a trophic role of metrifonate, based on a well-known neurotrophic activity of NGF and BDNF in vivo. PMID: 24948063 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Mele T, Jurič DM Tags: Pharmacol Rep Source Type: research

Interferon alpha and rapamycin inhibit the growth of carcinoid and medullary thyroid cancer in vitro.
Abstract Neuroendocrine tumors (NETs) are highly vascularized neoplasms characterized by rising incidence. Moreover, the neuroendocrine cells were shown to express vascular endothelial growth factor (VEGF) and VEGF receptors. Therefore, angiomodulators could be potentially a new group of drugs enhancing still unsatisfactory effectiveness of NET therapy. The aim of this study was to assess the direct influence of angiomodulators: VEGF and five endogenous and exogenous antiangiogenic compounds (endostatin, interferon alpha [IFNα], rapamycin, JV1-36, semaxinib [SU5416]) on the growth of two NET cell lines: lung carci...
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Motylewska E, Lawnicka H, Kowalewicz-Kulbat M, Sicinska P, Niedziela A, Melen-Mucha G, Stepien H Tags: Pharmacol Rep Source Type: research

The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain.
Abstract According to a current hypothesis of learning processes, recent papers pointed out to an important role of the extracellular signal-regulated kinase (ERK), in drug addiction. We employed the Western blotting techniques to examine the ERK activity immediately after cocaine iv self-administration and in different drug-free withdrawal periods in rats. To distinguish motivational vs. pharmacological effects of the psychostimulant intake, a "yoked" procedure was used. Animals were decapitated after 14 daily cocaine self-administration sessions or on the 1st, 3rd or 10th extinction days. At each time point the a...
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Miszkiel J, Detka J, Cholewa J, Frankowska M, Nowak E, Budziszewska B, Przegaliński E, Filip M Tags: Pharmacol Rep Source Type: research

A comparison of mecamylamine and bupropion effects on memory-related responses induced by nicotine and scopolamine in the novel object recognition test in mice.
CONCLUSIONS: The results of our studies unveiling neuronal mechanisms for cholinergic system of memory processes, via both nicotinic and muscarinic cholinergic receptors, will be useful for development of more effective pharmacotherapies for memory impairment-like treatment of human disorders in which cholinergic pathways have been implicated. PMID: 24948066 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Kruk-Słomka M, Michalak A, Budzyńska B, Biała G Tags: Pharmacol Rep Source Type: research

Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels.
CONCLUSIONS: Nimesulide at 100mg/kg prevented oxidative liver damage induced with I/R significantly better than at a dose of 50mg/kg. These experimental findings indicate that nimesulide may be useful in the treatment of hepatic I/R damage. PMID: 24948067 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Demiryilmaz I, Turan MI, Kisaoglu A, Gulapoglu M, Yilmaz I, Suleyman H Tags: Pharmacol Rep Source Type: research

Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice.
CONCLUSION: These results suggest that the antidepressant-like effect of creatine is dependent on PKA, CaMK-II, PKC and MEK 1/2 activation. PMID: 24948068 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 22, 2014 Category: Drugs & Pharmacology Authors: Cunha MP, Budni J, Pazini FL, Oliveira A, Rosa JM, Lopes MW, Leal RB, Rodrigues AL Tags: Pharmacol Rep Source Type: research