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MicroRNA Regulating Glutathione S-Transferase P1 in Prostate Cancer.
Abstract Glutathione S-transferase P1 (GSTP1), an enzyme involved in detoxification process, is frequently inactivated in prostate cancer due to epigenetic modifications. Through in silico analysis we identified a subset of miRNAs that are putative targets in regulating GSTP1. miRNAs are small endogenous non-coding RNA that are critical regulators of various physiologic and pathologic processes and their level of expression may play a precise role in early diagnosis and prognosis of cancer. These small molecules have been detected in a wide variety of human biological specimens including blood, serum, urine, ejacul...
Source: Pharmacological Reports - March 17, 2015 Category: Drugs & Pharmacology Authors: Singh S, Shukla GC, Gupta S Tags: Curr Pharmacol Rep Source Type: research

Impact of aliskiren on some hemostatic parameters in experimental arterial thrombosis in rats.
CONCLUSIONS: The presented results indicate that aliskiren inhibits hemostasis in the arterial thrombosis in rats. The antithrombotic effect is related with improvement of the fibrinolytic balance, and also depends on antiplatelet action. PMID: 25712636 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Hermanowicz JM, Buczko P, Tankiewicz-Kwedlo A, Hermanowicz A, Buczko W Tags: Pharmacol Rep Source Type: research

Differentiation of adult rat mesenchymal stem cells to GABAergic, dopaminergic and cholinergic neurons.
CONCLUSIONS: These new differentiation cocktails should be further investigated and in the next experiment only a part of MSCs that expressed the Cxcr4 receptor will be differentiated. We suppose that the Cxcr4(+) cells may differentiate more easily and as a result, we may achieve a homogenous population of one phenotype of neurons. PMID: 25712637 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Borkowska P, Fila-Danilow A, Paul-Samojedny M, Kowalczyk M, Hart J, Ryszawy J, Kowalski J Tags: Pharmacol Rep Source Type: research

Essential elements in depression and anxiety. Part II.
Abstract In this paper we continue to discuss the involvement of essential elements in depression and anxiety, and the possible mechanisms that link elements to the neurobiology underlying depression/anxiety. The present paper is focused on copper, selenium, manganese, iodine and vanadium. Different aspects of relationship between elements and depression or anxiety are reviewed, e.g. the association of the amount of an element in a diet or the serum level of an element and depressive or anxiety-like symptoms. Moreover, the relation of selected elements to the pathophysiology of depression or anxiety is discussed in...
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Młyniec K, Gaweł M, Doboszewska U, Starowicz G, Pytka K, Davies CL, Budziszewska B Tags: Pharmacol Rep Source Type: research

A review on Alzheimer's disease pathophysiology and its management: an update.
Abstract Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder, is the leading cause of dementia in late adult life. Pathologically it is characterized by intracellular neurofibrillary tangles and extracellular amyloidal protein deposits contributing to senile plaques. Over the last two decades, advances in the field of pathogenesis have inspired the researchers for the investigation of novel pharmacological therapeutics centered more towards the pathophysiological events of the disease. Currently available treatments i.e. acetylcholinesterase inhibitors (rivastigmine, galantamine,...
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Kumar A, Singh A, Ekavali Tags: Pharmacol Rep Source Type: research

Transcriptional and post-transcriptional regulation of CCN genes in failing heart.
CONCLUSION: CCN genes are activated in heart failure. Their regulation is multidimensional both transcriptional and posttranscriptional. The involved pathways include angiotensin II and IL-6. PMID: 25712640 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Bonda TA, Kożuch M, Litvinovich S, Bialuk I, Taranta A, Lipiec P, Szymczyk E, Musiał WJ, Winnicka MM, Kamiński KA Tags: Pharmacol Rep Source Type: research

Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy.
CONCLUSIONS: The results of this study seemed to indicate that the interaction between cannabinoid, COX-2 and NOS(s) systems might exist. Concomitant administration of small doses of CB1 and/or CB2 receptor agonists and COX-2 or NOS inhibitors can be effective in the alleviation of diabetic neuropathic pain. PMID: 25712641 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Bujalska-Zadrożny M, de Cordé A, Pawlik K Tags: Pharmacol Rep Source Type: research

Gambogic amide selectively upregulates TrkA expression and triggers its activation.
CONCLUSION: This study provides a novel mechanism of how gambogic amide regulates TrkA receptor, other than mimicking NGF in triggering TrkA activation. PMID: 25712642 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Shen J, Yu Q Tags: Pharmacol Rep Source Type: research

Current scenario in inflammatory bowel disease: Drug development prospects.
CONCLUSIONS: Preclinical research on the complex IBD puzzle coupled with an active and vibrant research agenda in recent decades which might reveal patterns of pharmacological interactions instead of single potential drug targets. The increased collaboration between pharmaceutical companies, basic researchers and clinical researchers has the potential to bring us closer to developing an optimum pharmaceutical approach for the treatment of IBD. PMID: 25712643 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Chandel S, Prakash A, Medhi B Tags: Pharmacol Rep Source Type: research

Protective effects of various dosage of Curcumin against morphine induced apoptosis and oxidative stress in rat isolated hippocampus.
CONCLUSIONS: These findings have demonstrated that Curcumin can act as an antioxidant and antiapoptotic agent against damage induced by morphine dependence. PMID: 25712644 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Motaghinejad M, Karimian M, Motaghinejad O, Shabab B, Yazdani I, Fatima S Tags: Pharmacol Rep Source Type: research

Synthesis and anticancer activity of 7-hydroxycoumarinyl gallates.
CONCLUSIONS: The novel compounds represent an excellent starting point for the further optimization and the design of therapeutically effective anti-cancerous drugs. PMID: 25712645 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Hejchman E, Taciak P, Kowalski S, Maciejewska D, Czajkowska A, Borowska J, Śladowski D, Młynarczuk-Biały I Tags: Pharmacol Rep Source Type: research

Antineoplastic effects of deoxypodophyllotoxin, a potent cytotoxic agent of plant origin, on glioblastoma U-87 MG and SF126 cells.
CONCLUSIONS: Taken together, our data demonstrated that DPT possesses a potent in vitro cytotoxic activity and exerts its effect via G2/M arrest and apoptosis. PMID: 25712646 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Guerram M, Jiang ZZ, Sun L, Zhu X, Zhang LY Tags: Pharmacol Rep Source Type: research

Low-dose ouabain administration increases Na(+),K(+)-ATPase activity and reduces cardiac force development in rats.
CONCLUSION: We suggest that the effects induced by ouabain in the isolated cardiac muscle could be related at least in part, to changes in NKA activity. PMID: 25712647 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Meira EF, Siman FD, Faria Tde O, Júnior RF, de Batista PR, Stefanon I, Vassallo DV, Padilha AS Tags: Pharmacol Rep Source Type: research

IL28B polymorphism (rs12979860) associated with clearance of HCV infection in Poland: Systematic review of its prevalence in chronic hepatitis C patients and general population frequency.
CONCLUSIONS: Events of spontaneous viral clearance can fully explain differences between genotype distributions in general population and chronic HCV subjects and a departure from the genetic equilibrium. This is the first study estimating the prevalence of IL28B rs12979860 SNP in the Southern Poland population based on a random representative sample. PMID: 25712648 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Kaczor MP, Seczyńska M, Szczeklik W, Sanak M Tags: Pharmacol Rep Source Type: research

Biofunctional studies of new 2-methoxyphenylpiperazine xanthone derivatives with α1-adrenolytic properties.
CONCLUSIONS: The results of the present study support the idea that the hypotensive activity of the studied compounds is related to their α1-adrenolytic properties. PMID: 25712649 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Rapacz A, Sapa J, Nowiński L, Mogilski S, Pytka K, Filipek B, Siwek A, Szkaradek N, Marona H Tags: Pharmacol Rep Source Type: research

The effects of valproate and olanzapine on the abnormal behavior of diacylglycerol kinase β knockout mice.
CONCLUSION: These results suggest that the abnormal behaviors of DGKβ KO mice is responsive to antimanic drugs, and that DGKβ KO mice are useful as an animal model of mania. PMID: 25712650 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Ishisaka M, Tsujii S, Mizoguchi T, Tsuruma K, Shimazawa M, Hara H Tags: Pharmacol Rep Source Type: research

Neuroprotective effect of noscapine on cerebral oxygen-glucose deprivation injury.
CONCLUSIONS: We concluded that noscapine had a neuroprotective effect, which could be due to its interference with multiple targets in the excitotoxicity process. These effects could be mediated partially by a decrease in NO production and the modulation of intracellular calcium levels. PMID: 25712651 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Vahabzadeh G, Rahbar-Roshandel N, Ebrahimi SA, Mahmoudian M Tags: Pharmacol Rep Source Type: research

Testicular effect of a mixture of 2-methoxyethanol and 2-ethoxyethanol in rats.
CONCLUSIONS: Marked testicular atrophy, decrease in epididymis and prostate weights are predominant effects of the repeated exposure to relatively low doses of ME and EE. A decrease in the total protein level, and protein sulfhydryl groups may be responsible for testicular atrophy. A significant depletion of non-protein sulfhydryl groups and occasionally elevated glutathione peroxidase activity may indicate that ME and EE resulted in disturbances of pro-oxidant/antioxidant balance. The study suggests that testicular toxicity in male rats co-exposed to ME and EE is mainly caused by the former compound. PMID: 25712652 [P...
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Starek-Świechowicz B, Szymczak W, Budziszewska B, Starek A Tags: Pharmacol Rep Source Type: research

Genetic polymorphism of ABCB1 gene (C3435T) in patients with inflammatory bowel diseases. Is there any gender dependency?
Conclusions. The 3435CT genotype could be a risk factor for IBD and CD in men. The 3435TT genotype in males seems to be associated with the lower chance of IBD presence. PMID: 25712653 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Jaźwińska-Tarnawska E, Jęśkowiak I, Waszczuk E, Mulak A, Głowacka K, Hurkacz M, Paradowski L, Zaleska Z, Wiela-Hojeńska A Tags: Pharmacol Rep Source Type: research

In vivo induction of CYP in mice by carbamazepine is independent on PXR.
CONCLUSIONS: These data suggest that in vivo induction of CYP in mice by multiple administration of CBZ is independent of PXR. Knowledge of the featured CYP induction profile in mice helps us understand species related CYP induction profiles among rodents and humans resulting from administration of CBZ. PMID: 25712654 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Liu A, Wang C, Hehir M, Zhou T, Yang J Tags: Pharmacol Rep Source Type: research

The effect of ezetimibe-statin combination on steroid hormone production in men with coronary artery disease and low cholesterol levels.
CONCLUSIONS: Our results indicate that ezetimibe combined with moderate statin dose exerts a less pronounced effect on testicular function in comparison with high-dose statin therapy. PMID: 25712655 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Krysiak R, Kowalska B, Żmuda W, Okopień B Tags: Pharmacol Rep Source Type: research

Ability of natural astaxanthin from shrimp by-products to attenuate liver oxidative stress in diabetic rats.
CONCLUSIONS: The results revealed that astaxanthin may be helpful in preventing diabetic complications in adult rats by reversing hepatotoxicity. It can be one of the ingredients in a number of healthy products. PMID: 25712656 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Sila A, Kamoun Z, Ghlissi Z, Makni M, Nasri M, Sahnoun Z, Nedjar-Arroume N, Bougatef A Tags: Pharmacol Rep Source Type: research

Neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity in guinea pigs.
CONCLUSIONS: Silymarin exerts superiority over 4-methylcatechol when recommended as protective agent against gentamicin ototoxicity based on its efficient neurotrophic and antioxidant activities. PMID: 25712657 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Draz EI, Abdin AA, Sarhan NI, Gabr TA Tags: Pharmacol Rep Source Type: research

Study of the protective effects of nootropic agents against neuronal damage induced by amyloid-beta (fragment 25-35) in cultured hippocampal neurons.
CONCLUSIONS: Our results suggest the protective potential of both studied nootropics against Aβ-induced death of cultured hippocampal neurons with more powerful neuroprotective effects of LEV. PMID: 25712658 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Sendrowski K, Sobaniec W, Stasiak-Barmuta A, Sobaniec P, Popko J Tags: Pharmacol Rep Source Type: research

The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation.
CONCLUSION: The obtained results showed that hypoxia/ischemia may trigger down-regulation of the brain AC-coupled PACAP/VIP receptors, with a consequent decrease of PACAP- and/or VIP-ergic-dependent cAMP-driven signaling. Moreover, our findings indicate that PACAP and VIP can prevent the deleterious effect of OGD on rat neuronal cells. PMID: 25712659 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Jóźwiak-Bębenista M, Kowalczyk E, Nowak JZ Tags: Pharmacol Rep Source Type: research

Effect of diosmin on the intestinal absorption and pharmacokinetics of fexofenadine in rats.
CONCLUSIONS: Diosmin significantly enhanced the oral bioavailability of fexofenadine by the inhibition of P-gp mediated drug efflux during the intestinal absorption. Co-administration of diosmin with fexofenadine can reduce the dosage and results in reduced side effects of fexofenadine. The clinical relevance of this interaction should be further evaluated in human subjects. PMID: 25712660 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Neerati P, Bedada SK Tags: Pharmacol Rep Source Type: research

Effect of desipramine on gene expression in the mouse frontal cortex - Microarray study.
CONCLUSIONS: It appears that one week of DMI administration measurably altered the expression of a small number of genes, including genes connected with neuroplasticity and cytoskeletal changes, the regulation of calcium levels in the cell or translation processes. PMID: 25712661 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Solich J, Kolasa M, Kuśmider M, Faron-Górecka A, Pabian P, Szafran K, Żurawek D, Dziedzicka-Wasylewska M Tags: Pharmacol Rep Source Type: research

Anxiogenic- and antidepressant-like behavior in corneally kindled rats.
CONCLUSIONS: Our results suggest that corneal kindling produces antidepressant- and anxiety-like effects in rats and it may be a useful model to study epilepsy-associated anxiety. PMID: 25712662 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Wlaź P, Poleszak E, Serefko A, Wlaź A, Rundfeldt C Tags: Pharmacol Rep Source Type: research

Therapeutic effect of aripiprazole in chronic schizophrenia is accompanied by anti-inflammatory activity.
CONCLUSIONS: Aripiprazole limits inflammatory processes by enhancing anti-inflammatory signaling. Aripiprazole also reduces the risk of metabolic abnormalities. PMID: 25712663 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Sobiś J, Rykaczewska-Czerwińska M, Świętochowska E, Gorczyca P Tags: Pharmacol Rep Source Type: research

Ergotamine and nicergoline - Facts and myths.
Abstract Ergotamine, being a representative of naturally occurring ergoline alkaloids, derived from d-lysergic acid, and nicergoline, a d-lumilysergic acid derivative belonging to semi-synthetic ergot-derived alkaloids, display diversified affinity for adrenergic, serotoninergic, and dopamine receptors. Although introduction of triptans marginalized use of ergotamine, nicergoline is used in cerebral metabolic-vascular disorders, and dementia. Additionally, nicergoline exhibits a safety profile comparable to that of placebo, and none of the reviewed studies reported any incidence of fibrosis or ergotism with nicergo...
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Zajdel P, Bednarski M, Sapa J, Nowak G Tags: Pharmacol Rep Source Type: research

Thioflavin T effect in diabetic Wistar rats: Reporting the antihyperglycemic property of an amyloid probing dye.
CONCLUSION: ThT is suggested to be a potentially useful compound in treatment and prevention of diabetes and associated complications. PMID: 25712665 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Najafian M, Amini S, Dehestani B, Parivar K, Ebrahim-Habibi A Tags: Pharmacol Rep Source Type: research

Omega-3 fatty acids prevent LPS-induced passive avoidance learning and memory and CaMKII-α gene expression impairments in hippocampus of rat.
CONCLUSION: Taken together, these data suggest that dietary omega-3 may improve cognitive function and provide a potential therapy for memory impairment due to neuroinflammation. PMID: 25712666 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Dehkordi NG, Noorbakhshnia M, Ghaedi K, Esmaeili A, Dabaghi M Tags: Pharmacol Rep Source Type: research

The effect of interleukin-35 on the integrity, ICAM-1 expression and apoptosis of human aortic smooth muscle cells.
CONCLUSION: Our data suggest that IL-35 may be an agent affecting the inflammatory properties of AoSMCs and thus it may regulate immune homeostasis of the vascular wall. Hence, IL-35 may be a novel player affecting Ao-SMC-controlled arterial wall immune homeostasis. PMID: 25712667 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Skowron W, Zemanek K, Wojdan K, Gorzelak P, Borowiec M, Broncel M, Chalubinski M Tags: Pharmacol Rep Source Type: research

Tectorigenin ablates the inflammation-induced epithelial-mesenchymal transition in a co-culture model of human lung carcinoma.
CONCLUSION: These results clearly demonstrate the therapeutic potential of tectorigenin to prevent lung cancer elicited inflammatory and pro-metastatic response in monocytes and warrants further investigations to elucidate its mechanism of action. PMID: 25712668 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Amin A, Mokhdomi TA, Bukhari S, Wani SH, Wafai AH, Lone GN, Qadri A, Qadri RA Tags: Pharmacol Rep Source Type: research

Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling.
CONCLUSION: Matrine can trigger mitochondrial apoptotic death of cholangiocarcinoma cells largely through inhibition of JAK2/STAT3 signaling. Therefore, matrine represents a potentially effective anticancer agent for cholangiocarcinoma. PMID: 25712669 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Yang N, Han F, Cui H, Huang J, Wang T, Zhou Y, Zhou J Tags: Pharmacol Rep Source Type: research

The effects of vasoactive peptide urocortin 2 on hemodynamics in spontaneous hypertensive rat and the role of L-type calcium channel and CRFR2.
CONCLUSION: UCN2 can modulate electrical remodeling of the myocardium and hemodynamics in an experimental model of SHR via inhibition of L-type calcium channel and CRFR2 in cardiomyocytes. PMID: 25712670 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Liu C, Liu X, Yang J, Duan Y, Yao H, Li F, Zhang X Tags: Pharmacol Rep Source Type: research

Involvement of nitridergic and opioidergic pathways in the antinociception of gabapentin in the orofacial formalin test in mice.
CONCLUSIONS: These results suggest that gabapentin produce antinociception partly via the activation nitridergic pathways and opioid system. PMID: 25712671 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Miranda HF, Sierralta F, Lux S, Troncoso R, Ciudad N, Zepeda R, Zanetta P, Noriega V, Prieto JC Tags: Pharmacol Rep Source Type: research

Selenitetriglycerides-Redox-active agents.
CONCLUSIONS: The anticancer activity of Selol involves perturbation of the redox regulation in the androgen dependent hPCa (LNCaP) cells, but not in healthy cells. After Selol treatment, intracellular Eh has increased in tumors from -223mV to -175mV, while in serum it has decreased (-82mV vs -113mV). It shows significant changes Eh in the extra- and intracellular environment. The difference decreases from 141mV to 62mV. The changes suggest that a tumor cell was probably directed toward apoptosis. This is exemplified in a significant decrease in cancer tumor mass by approx. 17% after the three weeks of Selol administration....
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Flis A, Suchocki P, Królikowska MA, Suchocka Z, Remiszewska M, Śliwka L, Książek I, Sitarz K, Sochacka M, Hoser G, Anuszewska E, Wroczyński P, Jastrzębski Z Tags: Pharmacol Rep Source Type: research

Analgesic activity of new 8-methoxy-1,3-dimethyl-2,6-dioxo-purin-7-yl derivatives with carboxylic, ester or amide moieties.
CONCLUSION: The present study revealed that the presented compounds are new class of analgesic and anti-inflammatory agents and are worthy of the further evaluation regarding to their pharmacological properties. PMID: 25560569 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Zygmunt M, Chłoń-Rzepa G, Sapa J, Pawłowski M Tags: Pharmacol Rep Source Type: research

H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway.
CONCLUSION: This study suggests a novel therapeutic approach for diabetic nephropathy using H2S donors. PMID: 25560570 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Safar MM, Abdelsalam RM Tags: Pharmacol Rep Source Type: research

Multifactorial effects of vildagliptin added to ongoing metformin therapy in patients with type 2 diabetes mellitus.
CONCLUSIONS: Vildagliptin added to an ongoing metformin therapy allows to achieve better metabolic control parameters in comparison with a metformin monotherapy and the combination treatment is well tolerated and has a low risk of serious adverse effects. PMID: 25560571 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Strózik A, Stęposz A, Basiak M, Drożdż M, Okopień B Tags: Pharmacol Rep Source Type: research

HMG-COA reductase inhibitors: An opportunity for the improvement of imatinib safety. An experimental study in rat pulmonary hypertension.
CONCLUSIONS: Statins may intensify the beneficial effects of imatinib in PAH, which may be due to the additional influence of statin on the decrease of platelet-derived growth factor (PDGF)-induced effects. These properties allow the dose of imatinib used in PAH treatment to be reduced and thereby might improve its safety profile. PMID: 25560572 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Jasińska-Stroschein M, Owczarek J, Surowiecka A, Kącikowska J, Orszulak-Michalak D Tags: Pharmacol Rep Source Type: research

Impact of sparfloxacin on melanogenesis and antioxidant defense system in normal human melanocytes HEMa-LP - An in vitro study.
CONCLUSIONS: The observed sparfloxacin-dependent inhibition of melanogenesis and changes of antioxidant enzymes activities in human melanocytes give a new insight into the mechanism of fluoroquinolones toxicity directed to pigmented tissues. PMID: 25560573 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Beberok A, Wrześniok D, Otręba M, Buszman E Tags: Pharmacol Rep Source Type: research

Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of nifedipine in rats: Possible role of P-gp and CYP3A4 inhibition by HMG-CoA reductase inhibitors.
CONCLUSION: The increased bioavailability of nifedipine may be mainly due to inhibition of both P-gp in the small intestine and CYP3A subfamily-mediated metabolism of nifedipine in the small intestine and/or in the liver and to the reduction of the CL/F of nifedipine by fluvastatin and simvastatin. PMID: 25560574 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Lee CK, Choi JS, Choi DH Tags: Pharmacol Rep Source Type: research

Dezocine prevents sufentanil-induced cough during general anesthesia induction: A randomized controlled trial.
CONCLUSION: The results of current study suggest that administration of Dezocine 0.1mg/kg may effectively prevent the occurrence and reflex degree of sufentanil-induced irritating cough in general anesthesia induction in patients. PMID: 25560575 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Liu XS, Xu GH, Shen QY, Zhao Q, Cheng XQ, Zhang J, Gu EW Tags: Pharmacol Rep Source Type: research

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics.
Abstract Noscapine and its synthetic derivatives called noscapinoids have been shown to possess potential anticancer properties. These alkaloids target microtubules and inhibit cell proliferation. Noscapinoids are microtubule poisons that induce minor alterations in the innate dynamic instability of microtubules leading to mitotic arrest and cell death. Over the past decade, a number of noscapine derivatives have been synthesized that, compared to the parent compound, show superior anticancer potential, enhanced tumor specificity and tumor regression, and little or no toxicity to normal tissues. Based on their succ...
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Lopus M, Naik PK Tags: Pharmacol Rep Source Type: research

Antinociceptive properties of N-Mannich bases derived from 3-substituted pyrrolidine-2,5-dione in the formalin model of persistent pain in mice.
CONCLUSIONS: The results of the research indicate that some of the investigated compounds reduced effectively either both phases of the test or were able to attenuate pain during only the acute or late phase of the formalin test. These properties, which are particularly strong in case of the compounds 1-3, 5, 6, 9 and 14, might be relevant for the development of novel analgesic-active compounds and their possible use in neuropathic pain syndromes. PMID: 25560577 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Obniska J, Sałat K, Librowski T, Kamiński K, Lipkowska A, Wiklik B, Rybka S, Rapacz A Tags: Pharmacol Rep Source Type: research

Effects of incretin agonists on endothelial nitric oxide synthase expression and nitric oxide synthesis in human coronary artery endothelial cells exposed to TNFα and glycated albumin.
CONCLUSIONS: TNFα and GA decrease production of NO in HCAEC, presumably by inducing reactive oxygen species or eNOS uncoupling. Incretin agonists in tested concentrations in the presence of l-arginine were not able to reverse this effect and instead led to a further reduction in NO production. PMID: 25560578 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Garczorz W, Francuz T, Siemianowicz K, Kosowska A, Kłych A, Aghdam MR, Jagoda K Tags: Pharmacol Rep Source Type: research

Pioglitazone prevents morphine antinociceptive tolerance via ameliorating neuroinflammation in rat cerebral cortex.
CONCLUSION: It is concluded that oral administration of pioglitazone attenuates morphine-induced tolerance. This effect of pioglitazone may be, at least in part, due to its anti-inflammatory property which suppressed the cortical pro-inflammatory cytokine and inhibited of nuclear factor-kappa B activity. PMID: 25560579 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Ghavimi H, Charkhpour M, Ghasemi S, Mesgari M, Hamishehkar H, Hassanzadeh K, Arami S, Hassanzadeh K Tags: Pharmacol Rep Source Type: research

The MCP-1, CCL-5 and SDF-1 chemokines as pro-inflammatory markers in generalized anxiety disorder and personality disorders.
CONCLUSIONS: Our study has shown the need for determination of proinflammatory interleukins which are considered as biomarkers of personality disorders and generalized anxiety disorders. PMID: 25560580 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Ogłodek EA, Szota AM, Just MJ, Moś DM, Araszkiewicz A Tags: Pharmacol Rep Source Type: research