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CP55,940 attenuates spatial memory retrieval in mice.
CONCLUSION: Since the attenuated psychomotor activity after a dose of 0.125mg/kg did not interfere with memory retrieval, we assume that the impairment of spatial memory observed after the highest dose of CP55,940 (0.25mg/kg) was exerted by its influence on cognitive processes, however, the impact on locomotion could not be excluded. PMID: 25443717 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Bialuk I, Dobosz K, Potrzebowski B, Winnicka MM Tags: Pharmacol Rep Source Type: research

Antiproliferative effect induced by novel imidazoline S43126 in PC12 cells is mediated by ROS, stress activated MAPKs and caspases.
CONCLUSION: Our data showed that the effects of S43126 on PC12 cell death were partly mediated by ROS production, MAPK and caspase activation. These results further indicate an emerging role for I1R in apoptotic processes. PMID: 25443718 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: McLean LS, Crane L, Baziard-Mouysset G, Edwards LP Tags: Pharmacol Rep Source Type: research

Chronic administration of phenytoin induces efflux transporter overexpression in rats.
CONCLUSIONS: Overexpression of efflux transporters can be mediated by inducer agents like PHT in a local-concentration dependent manner, and it is reversible once the substance is removed from the body. The recovery of basal Pgp expression could allow the design of dosing schedules that optimize anticonvulsant therapy. PMID: 25443719 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Alvariza S, Fagiolino P, Vázquez M, Feria-Romero I, Orozco-Suárez S Tags: Pharmacol Rep Source Type: research

Rupatadine effectively prevents the histamine-induced up regulation of histamine H1R and bradykinin B2R receptor gene expression in the rat paw.
CONCLUSION: Rupatadine has a suppressing effect on H1R and B2R gene expression which could add to its efficacy towards allergy and allergy-like conditions. PMID: 25443720 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Molyva D, Kalokasidis K, Poulios C, Dedi H, Karkavelas G, Mirtsou V, Goulas A Tags: Pharmacol Rep Source Type: research

Potential of metabolomics in preclinical and clinical drug development.
Abstract Metabolomics is an upcoming technology system which involves detailed experimental analysis of metabolic profiles. Due to its diverse applications in preclinical and clinical research, it became an useful tool for the drug discovery and drug development process. This review covers the brief outline about the instrumentation and interpretation of metabolic profiles. The applications of metabolomics have a considerable scope in the pharmaceutical industry, almost at each step from drug discovery to clinical development. These include finding drug target, potential safety and efficacy biomarkers and mechanism...
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Kumar B, Prakash A, Ruhela RK, Medhi B Tags: Pharmacol Rep Source Type: research

Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia.
CONCLUSIONS: Data suggest that TRPV1 and ASIC3 participate in the development and maintenance of long-lasting secondary allodynia and hyperalgesia induced by formalin in rats. The use of TRPV1 and ASIC3 antagonists by peripheral administration could prove useful to treat chronic pain. PMID: 25443722 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Martínez-Rojas VA, Barragán-Iglesias P, Rocha-González HI, Murbartián J, Granados-Soto V Tags: Pharmacol Rep Source Type: research

Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate.
CONCLUSIONS: The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. PMID: 25443723 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Steinborn B, Zarowski M, Winczewska-Wiktor A, Wójcicka M, Młodzikowska-Albrecht J, Losy J Tags: Pharmacol Rep Source Type: research

Evaluation of l-arginine on kidney function and vascular reactivity following ischemic injury in rats: Protective effects and potential interactions.
CONCLUSIONS: The protective effect of l-arginine may result from the interaction between NO and ROS and increased NO bioavailability. The protective effects of combined celecoxib and l-arginine against IRI could be attributed to their antioxidant activity which exceeded that of ascorbic acid. PMID: 25443724 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Senbel AM, Omar AG, Abdel-Moneim LM, Mohamed HF, Daabees TT Tags: Pharmacol Rep Source Type: research

The effect of risperidone on the mirtazapine-induced changes in extracellular monoamines in the rat frontal cortex.
CONCLUSIONS: Our data indicate that the increase of cortical extracellular levels of DA and NA by combined administration of mirtazapine and risperidone may be of crucial importance to the pharmacotherapy of drug resistant depression, and that, among other mechanisms, 5-HT1A, 5-HT2A, α2-adrenergic and histamine H1 receptors may play some role in this effect. PMID: 25443725 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Kamińska K, Gołembiowska K, Rogóż Z Tags: Pharmacol Rep Source Type: research

Hypotensive effects of omentin-1 related to increased adiponectin and decreased interleukin-6 in intra-thoracic pericardial adipose tissue.
CONCLUSION: We conclude that the hypotensive effects of omentin-1 could be driven by stimulated production of NO in the vascular system, possibly related to increased adiponectin and decreased IL-6 mRNA in PAT. PMID: 25443726 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Brunetti L, Leone S, Orlando G, Ferrante C, Recinella L, Chiavaroli A, Di Nisio C, Shohreh R, Manippa F, Ricciuti A, Vacca M Tags: Pharmacol Rep Source Type: research

Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones.
CONCLUSION: Active compounds (1-6) inhibited the PDE activity, while compound 1 significantly inhibited the PDE4B activity, what may suggest that this mechanism may be involved in their analgesic/anti-inflammatory properties. PMID: 25443727 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Zygmunt M, Chłoń-Rzepa G, Sapa J Tags: Pharmacol Rep Source Type: research

Integrated workflow for quantitative phosphoproteomic analysis of the selected brain structures in development of morphine dependence.
CONCLUSIONS: The proposed MS-based workflow with following data analysis is efficient method for quantitative phosphoproteomic analysis: PMID: 25443728 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Sucharski F, Noga MJ, Suder P, Kotlińska J, Silberring J Tags: Pharmacol Rep Source Type: research

Ligand-directed trafficking of receptor stimulus.
Abstract GPCRs are seven transmembrane-spanning receptors that convey specific extracellular stimuli to intracellular signalling. They represent the largest family of cell surface proteins that are therapeutically targeted. According to the traditional two-state model of receptor theory, GPCRs were considered as operating in equilibrium between two functional conformations, an active (R*) and inactive (R) state. Thus, it was assumed that a GPCR can exist either in an "off" or "on" conformation causing either no activation or equal activation of all its signalling pathways. Over the past several years it has become ...
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Chilmonczyk Z, Bojarski AJ, Sylte I Tags: Pharmacol Rep Source Type: research

Antiarrhythmic efficacy of CPUY102122, a multiple ion channel blocker, on rabbits with ischemia/reperfusion injury.
CONCLUSIONS: These results indicated that CY22 has both antiarrhythmic and cardiovascular protective effects partly by blocking IKr, the production of antioxidants and protection of Cx43. PMID: 25443730 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Wang M, Shan J, Yang Q, Ma X, Jin S, Guo X, You Q, Tang Y Tags: Pharmacol Rep Source Type: research

The effects of ifenprodil on the activity of antidepressant drugs in the forced swim test in mice.
CONCLUSION: The concomitant administration of certain commonly prescribed antidepressant drugs that affect the serotonergic neurotransmission (i.e., typical tricyclic antidepressants and selective serotonin reuptake inhibitors) with a negative modulator selectively binding to the GluN1/N2B subunits of the NMDA receptor complex (i.e., ifenprodil) may induce a more pronounced antidepressant-like effect than monotherapy. However, these findings still need to be confirmed in further experiments. PMID: 25443731 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Poleszak E, Wośko S, Serefko A, Wlaź A, Kasperek R, Dudka J, Wróbel A, Nowak G, Wlaź P Tags: Pharmacol Rep Source Type: research

Chronotherapeutic effect of fisetin on expression of urea cycle enzymes and inflammatory markers in hyperammonaemic rats.
CONCLUSIONS: Fisetin could exhibit anti-hyperammonaemic effect owing to its anti-oxidant and cytoprotective influences. The temporal variation in the effect of fisetin could be due to the (i) chronopharmacological, chronopharmacokinetic properties of fisetin and (ii) modulations in the endogenous circadian rhythms of urea cycle enzymes, brain markers, redox enzymes and renal clearance during hyperammonaemia by fisetin. However, future studies in these lines are necessitated. PMID: 25443732 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Subramanian P, Jayakumar M, Jayapalan JJ, Hashim OH Tags: Pharmacol Rep Source Type: research

Ramipril/amlodipine single pill - Effectiveness, tolerance and patient satisfaction with antihypertensive therapy in relation to nutritional status.
CONCLUSIONS: The effectiveness of therapy with ramipril/amlodipine FDC in the study population was high, but slightly lower in overweigh and obese. This FDC was well tolerated and a significant number of patients satisfied with the therapy regardless of nutritional status. Although the perceived tolerance and satisfaction with treatment were lower in obese and overweight than in normal weight patients; the incidence of AE and perceived benefit from the use of a single-pill, compared to multiple tablets, were comparable irrespective of nutritional status. PMID: 25443733 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Olszanecka-Glinianowicz M, Smertka M, Almgren-Rachtan A, Chudek J Tags: Pharmacol Rep Source Type: research

Alleviation of hepatic injury by chrysin in cisplatin administered rats: Probable role of oxidative and inflammatory markers.
CONCLUSION: The results of the present study demonstrate that oxidative stress and inflammation are closely associated with cisplatin-induced toxicity and chrysin shows the protective efficacy against cisplatin-induced hepatotoxicity possibly via attenuating the oxidative stress and inflammatory response. PMID: 25443734 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Rehman MU, Ali N, Rashid S, Jain T, Nafees S, Tahir M, Khan AQ, Lateef A, Khan R, Hamiza OO, Kazim S, Qamar W, Sultana S Tags: Pharmacol Rep Source Type: research

The anti-cancer actions of O6-methylguanine-DNA-methyltransferase in relation to colon polyps.
CONCLUSIONS: We concluded that high frequency of 84F allele in the group of patients may suggest the role of the MGMT variant in colon polyps etiology. PMID: 25443735 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Kycler W, Korski K, Loziński C, Teresiak-Mańczak A, Przybyła A, Mackiewicz A, Cybulski Z, Lamperska K Tags: Pharmacol Rep Source Type: research

Modulating actions of NMDA receptors on pronociceptive effects of locally injected remifentanil in diabetic rats.
CONCLUSIONS: The hyperalgesic and allodynic actions of locally treated remifentanil may decrease in diabetic conditions. Increases in NMDA receptors activation, reactive oxygen species production and NO release may modify the sensitivity to remifentanil in diabetes induced neuropathic pain states. PMID: 25443736 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Mert T, Oksuz H, Tugtag B, Kilinc M, Senoglu N, Bilgin R Tags: Pharmacol Rep Source Type: research

Apoptotic mechanisms of the biotechnologically produced arylnaphtalene lignan justicidin B in the acute myeloid leukemia-derived cell line HL-60.
CONCLUSION: The potent activity at low micromolar concentration and the feasibility of biotechnological production of justicidin B implies that there is enormous scope in its further evaluation as possible antineoplastic drug candidate. PMID: 25443737 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Momekov G, Yossifov D, Guenova M, Michova A, Stoyanov N, Konstantinov S, Ionkov T, Sacheva P, Ionkova I Tags: Pharmacol Rep Source Type: research

Daytime sleepiness and EEG abnormalities in patients treated with second generation antipsychotic agents.
CONCLUSIONS: Although antipsychotics may have profound effects on EEG patients with schizophrenia do not have higher daytime sleepiness than patients with anxiety/personality disorders. Patients with schizophrenia may compensate sedative effects of antipsychotic treatment with sleep duration prolongation and report even less sleepiness than non-psychotic patients. PMID: 25443738 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Okruszek L, Jernajczyk W, Wierzbicka A, Waliniowska E, Jakubczyk T, Jarema M, Wichniak A Tags: Pharmacol Rep Source Type: research

Celecoxib prevents colitis associated colon carcinogenesis: An upregulation of apoptosis.
CONCLUSION: The chemopreventive action of celecoxib in colitis mediated colon carcinogenesis may include the regulation of DNA mismatch repair enzymes, cell cycle check points, cell proliferation and apoptosis. PMID: 25443739 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Setia S, Nehru B, Sanyal SN Tags: Pharmacol Rep Source Type: research

Antithyroid effects of naringin, hesperidin and rutin in l-T4 induced hyperthyroid rats: Possible mediation through 5'DI activity.
CONCLUSION: Rutin, naringin and hesperidin have the potential to inhibit thyroid functions without hepatotoxicity and the effects are possibly mediated through their free radical scavenging action as evidenced by EPR study. From the comparative analyses of the results, rutin appeared to be the most effective one suggesting its better antithyroid and antioxidative potential over other two. PMID: 25443740 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Panda S, Kar A Tags: Pharmacol Rep Source Type: research

Interactions between levetiracetam and cardiovascular drugs against electroconvulsions in mice.
CONCLUSIONS: Although experimental data can be hardly extrapolated to clinical practice, it is suggested that perindopril arginine may positively influence the anticonvulsant action of LEV in epileptic patients. The use of losartan potassium, candesartan cilexetil, captopril, hydrochlorothiazide or ethacrynic acid in patients treated with LEV seems neutral regarding its anticonvulsant activity. PMID: 25443741 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Lukawski K, Raszewski G, Czuczwar SJ Tags: Pharmacol Rep Source Type: research

Palmitic acid-induced lipotoxicity and protection by (+)-catechin in rat cortical astrocytes.
CONCLUSION: Our results suggest that PA-induced cytotoxicity in astrocytes may involve ROS generation and MMP collapse, which can be prevented by (+)-catechin. PMID: 25443742 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Wong KL, Wu YR, Cheng KS, Chan P, Cheung CW, Lu DY, Su TH, Liu ZM, Leung YM Tags: Pharmacol Rep Source Type: research

Effect of propranolol on IL-10, visfatin, Hsp70, iNOS, TLR2, and survivin in amelioration of tumor progression and survival in Solid Ehrlich Carcinoma-bearing mice.
CONCLUSIONS: Propranolol could provide palliative effects in progression and survival of breast cancer that are mainly mediated via direct immunomodulatory and apoptotic mechanisms and probably associated with indirect anti-angiogenic activity. PMID: 25443743 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Abdin AA, Soliman NA, Saied EM Tags: Pharmacol Rep Source Type: research

The influence of amitriptyline and carbamazepine on levomepromazine metabolism in human liver: An in vitro study.
CONCLUSION: Regarding the central and peripheral effects of levomepromazine and some of its metabolites, the observed metabolic interaction between this neuroleptic and carbamazepine may be of pharmacological and clinical importance. PMID: 25443744 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Wójcikowski J, Basińska A, Boksa J, Daniel WA Tags: Pharmacol Rep Source Type: research

On the toxicity of kynurenic acid in vivo and in vitro.
CONCLUSIONS: The obtained results showed that a long-term application of KYNA in the drinking water is well-tolerated by rodents. No evidence of a toxic response was recorded. Achieved results indicate that diets containing a high amount of KYNA or enriched with KYNA should not cause any risk to the human health. PMID: 25443745 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Turski WA, Małaczewska J, Marciniak S, Bednarski J, Turski MP, Jabłoński M, Siwicki AK Tags: Pharmacol Rep Source Type: research

Experimental diabetes mellitus type 1 increases hippocampal content of kynurenic acid in rats.
CONCLUSIONS: A novel factor potentially implicated in diabetic hippocampal dysfunction has been identified. Observed increase of KYNA level may stem from the activation of endogenous neuroprotection, however, it may also have negative impact on cognition. PMID: 25443746 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Chmiel-Perzyńska I, Perzyński A, Urbańska EM Tags: Pharmacol Rep Source Type: research

L-1416, a novel MDR reversing agent with possible reduced calcium antagonism.
CONCLUSION: The novel compound 1416 could significantly increase the antitumor effects of cytotoxic drugs and one of its optical isomers, L-1416, might be more promising due to its potential low calcium antagonism. PMID: 25443747 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Zhou Z, Tang X, Zhang Y, Hu Z, Wu J, Hu Y Tags: Pharmacol Rep Source Type: research

Improvement of mitochondrial NAD(+)/FAD(+)-linked state-3 respiration by caffeine attenuates quinolinic acid induced motor impairment in rats: Implications in Huntington's disease.
CONCLUSION: The study highlights the possible involvement of A2A receptor antagonism in the neuroprotective effect of caffeine against QA induced mitochondrial dysfunction and oxidative stress in rats. PMID: 25443748 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Mishra J, Kumar A Tags: Pharmacol Rep Source Type: research

Gene Therapy for Hemophilia B with liver-specific element mediated by Rep-RBE site-specific integration system.
In this study, we established a novel hFIX expression plasmid, pRBE-HCR-hAAT-hFIX, driven by a liver specific promoter by replacing the CMV promoter of pRBE-CMV-hFIX with a humanized promoter consisting of HCR-hAAT. The expression of hFIX in vitro was almost the same in transient transfection of pRBE-CMV-hFIX or pRBE-HCR-hAAT-hFIX. AAVS1 specific integrations were identified both in mice transfected with pRC /pRBE-CMV-hFIX cocktail and pRC/ pRBE-HCR-hAAT-hFIX cocktail. However, the expression of hFIX of pRBE-HCR-hAAT-hFIX mice was higher and persisted longer. It achieved more than 1% of normal plasma hFIX concentration and...
Source: Pharmacological Reports - October 7, 2014 Category: Drugs & Pharmacology Authors: Xu Z, Ye J, Zhang A, Xie L, Shen Q, Xue J, Chen J Tags: J Cardiovasc Pharmacol Source Type: research

Phenylbutazone and ketoprofen binding to serum albumin. Fluorescence study.
CONCLUSIONS: The conclusion, that both PBZ and KP form a binding site in the same subdomains (IIA or/and IB), points to the necessity of using a monitoring therapy owning to the possible increase of the uncontrolled toxic effects. PMID: 25149974 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Maciążek-Jurczyk M Tags: Pharmacol Rep Source Type: research

The effect of resveratrol and its methylthio-derivatives on NF-κB and AP-1 signaling pathways in HaCaT keratinocytes.
CONCLUSIONS: We conclude that methylthiostilbenes differently modulate constitutive signal transduction pathways in HaCaT cells. These observations should be taken into account in designing new stilbene derivatives with potential chemopreventive activity. PMID: 25149975 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Szaefer H, Cichocki M, Krajka-Kuźniak V, Stefański T, Sobiak S, Licznerska B, Baer-Dubowska W Tags: Pharmacol Rep Source Type: research

Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases.
CONCLUSION: Our results show a potent anti-inflammatory and antinociceptive effect of P-317 in mouse models of colitis upon activation of opioid receptors. The unique bioavailability of P-317 after oral administration suggests that it is a promising drug candidate for future treatment of IBD. PMID: 25149976 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Sobczak M, Zakrzewski PK, Cygankiewicz AI, Mokrowiecka A, Chen C, Sałaga M, Małecka-Panas E, Kordek R, Krajewska WM, Fichna J Tags: Pharmacol Rep Source Type: research

Exogenous hydrogen sulfide causes different hemodynamic effects in normotensive and hypertensive rats via neurogenic mechanisms.
CONCLUSIONS: The results provide further evidence for the involvement of H2S in the neurogenic regulation of the circulatory system and suggest that alterations in H2S signaling in the brain could be associated with hypertension. PMID: 25149977 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Sikora M, Drapala A, Ufnal M Tags: Pharmacol Rep Source Type: research

Comparison of chosen activation markers of human monocytes/macrophages isolated from the peripheral blood of young and elderly volunteers.
CONCLUSIONS: The changes observed in the macrophages isolated from the elderly indicate that these cells could contribute to the development of metabolic disorders like atherosclerosis and diabetes. The cells from the young volunteers are less likely to present such properties. PMID: 25149978 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Suchy D, Labuzek K, Bułdak L, Szkudłapski D, Okopień B Tags: Pharmacol Rep Source Type: research

Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases.
Abstract Inflammatory bowel diseases (IBD) are chronic, relapsing disorders affecting gastrointestinal (GI) tract and associated with intestinal mucosa damage and inflammation. The principal therapeutic goals in IBD include control of the intestinal inflammation and treatment of the major symptoms, mainly abdominal pain and diarrhea. Current therapeutic strategies for IBD rely on the use of non-specific anti-inflammatory agents and immunosuppressive drugs (e.g. aminosalicylates, monoclonal antibodies, and antibiotics), which cause severe side effects, and - in a significant number of patients - do not induce long-t...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Sobczak M, Fabisiak A, Murawska N, Wesołowska E, Wierzbicka P, Wlazłowski M, Wójcikowska M, Zatorski H, Zwolińska M, Fichna J Tags: Pharmacol Rep Source Type: research

The role of the neuroendocrine and immune systems in the pathogenesis of depression.
This article illustrates the involvement of key mediators of allostasis such as the neuroendocrine and immune systems, in the pathogenesis of depression. The literature concerning the contribution of the neuroendocrine and immune systems to depression incidence was reviewed. Development of depression is associated with disturbance of the body's allostasis and inflammatory activation of the immune system. It leads to a chronic increase in the concentration of cortisol and proinflammatory cytokines, which results in an allostatic load. This load leads to neurodegeneration, eventually causing irreversible cognitive impairment...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Ogłodek E, Szota A, Just M, Moś D, Araszkiewicz A Tags: Pharmacol Rep Source Type: research

Curcumin influences semen quality parameters and reverses the di(2-ethylhexyl)phthalate (DEHP)-induced testicular damage in mice.
CONCLUSION: The effects of curcumin were dependent on its concentration. In male germ cells in vivo the protective effect was seen despite the low bioavailability of curcumin. In contrast, high, unattainable in the organism, concentration of curcumin had a cytotoxic effect on male reproductive cells in vitro. Curcumin also had a protective effect against the harmful impact of DEHP on the male reproductive system. PMID: 25149981 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Głombik K, Basta-Kaim A, Sikora-Polaczek M, Kubera M, Starowicz G, Styrna J Tags: Pharmacol Rep Source Type: research

Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells.
CONCLUSIONS: Incorporating the phytosomal form of silymarin in liposomal carrier system increased the oral bioavailability and showed better hepatoprotection and better anti-inflammatory effects compared with silymarin suspension. PMID: 25149982 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Kumar N, Rai A, Reddy ND, Raj PV, Jain P, Deshpande P, Mathew G, Kutty NG, Udupa N, Rao CM Tags: Pharmacol Rep Source Type: research

Therapeutic potential of resveratrol in diabetic complications: In vitro and in vivo studies.
CONCLUSIONS: The results obtained in this study underline the potential of RSV as a possible therapeutic agent against long-term diabetic complications. PMID: 25149983 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Ciddi V, Dodda D Tags: Pharmacol Rep Source Type: research

Neuropharmacological effect of novel 5-HT3 receptor antagonist, N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n) on chronic unpredictable mild stress-induced molecular and cellular response: Behavioural and biochemical evidences.
CONCLUSION: Compound 6n produced antidepressant-like effects in behavioural despair paradigm in chronically stressed mice by restoring antioxidant enzyme activity up to significant level. PMID: 25149984 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Bhatt S, Mahesh R, Jindal A, Devadoss T Tags: Pharmacol Rep Source Type: research

The latest achievements in the pharmacotherapy of gambling disorder.
Abstract Gambling disorder (GD) is becoming increasingly prevalent both among adults and adolescents. Unfortunately, this disorder is largely underestimated, while it can still lead to serious social and personal consequences, including criminal behavior or suicide attempts. In the past, the only means of treating gambling were psychobehavioral therapies. Nowadays, this disorder could also respond to many drugs from different classes such as opioid antagonists, serotonin selective reuptake inhibitors, mood stabilizers, atypical antipsychotics or glutamatergic agents. This review presents current pharmacological str...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Labuzek K, Beil S, Beil-Gawełczyk J, Gabryel B, Franik G, Okopień B Tags: Pharmacol Rep Source Type: research

Pharmacokinetics and pharmacodynamics of propofol in children undergoing different types of surgeries.
CONCLUSIONS: The BIS values in children are highly correlated with the propofol effect compartment concentrations according to the classical Emax concentration-response relationship. Children had slightly lower sensitivity to propofol and slightly higher clearance, as compared with the adult data available in literature. The intra-patient variations in the BIS require the anesthesiologist's attention in using BIS values alone to evaluate the depth of anesthesia in children. PMID: 25149986 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Bartkowska-Śniatkowska A, Bienert A, Wiczling P, Owczarek M, Rosada-Kurasińska J, Grześkowiak M, Matysiak J, Kokot ZJ, Kaliszan R, Grześkowiak E Tags: Pharmacol Rep Source Type: research

Neuroligins, synapse balance and neuropsychiatric disorders.
Abstract Neuroligins are postsynaptic adhesion molecules that are involved in the regulation of synapse organisation and function. Four neuroligin proteins have been identified (neuroligin 1, 2, 3, 4), which are differentially enriched in the postsynaptic specialisation of synapses. Neuroligin 1 is localised on excitatory (glutamatergic) synapses, whereas neuroligin 2 is located on inhibitory (GABAergic/glycinergic) synapses. Neuroligin 3 and 4 are present on both types of synapses. Recent data indicate that neuroligins are involved in synapse maturation and specification. Because of their synaptic localisation and...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Maćkowiak M, Mordalska P, Wędzony K Tags: Pharmacol Rep Source Type: research

TNF inhibitors - Mechanisms of action, approved and off-label indications.
Abstract Tumor necrosis factor inhibitors (TNFi) belong to the group of biologic drugs, holding presently top positions on lists of most profitable products for pharmaceutical companies. Although current indications for TNFi include only selected diseases with an established role of immune dysfunction in their pathogenesis, studies on new indications are being carried out all over the world. The most important aspect of TNFi therapy is a targeted therapeutic approach, allowing to avoid a wide range of side effects associated with treatment with nonspecific immunosuppressive agents. Results of the trials on TNFi in ...
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Cessak G, Kuzawińska O, Burda A, Lis K, Wojnar M, Mirowska-Guzel D, Bałkowiec-Iskra E Tags: Pharmacol Rep Source Type: research

Inhibition of intracellular signaling pathways NF-κB and MEK1/2 attenuates neuropathic pain development and enhances morphine analgesia.
CONCLUSIONS: These results indicate that the inhibition of the NF-κB pathway has better analgesic effects. Both inhibitors similarly potentiate morphine analgesia, which parallels the up-regulation of both mor and dor mRNAs expression spinal levels of the model of neuropathy. PMID: 25149989 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Popiolek-Barczyk K, Makuch W, Rojewska E, Pilat D, Mika J Tags: Pharmacol Rep Source Type: research

Vague effects of chronic topiramate administration on maximal electroshock-induced seizures in mice.
CONCLUSIONS: Maximal electroshock in mice does not seem to be an appropriate seizure model to test anticonvulsant effects of chronic topiramate. PMID: 25149990 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2014 Category: Drugs & Pharmacology Authors: Banach M, Szpot P, Buszewicz G, Borowicz KK Tags: Pharmacol Rep Source Type: research