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Characteristics, diagnosis and therapeutic strategies for IgG4-related orbital disease.
Abstract Thanks to detailed studies conducted in recent years, a new disease syndrome was identified in 2001. It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs. Orbital IgG4-related disease is a recently reported issue that may prove important for the elucidation of the etiology of idiopathic, lymphoplasmacytic or fibrotic disorders of various organs, including the orbits. In this art...
Source: Pharmacological Reports - April 29, 2016 Category: Drugs & Pharmacology Authors: Oles K, Sładzień J, Bartuś K, Leszczyńska J, Bojanowska E, Krakowczyk Ł, Mika J Tags: Pharmacol Rep Source Type: research

Natural terpenoids as a promising source for modulation of GABAergic system and treatment of neurological diseases.
Abstract γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter reducing neural excitability in the mammalian central nervous system (CNS) with three subclasses of receptors. Several conventional drugs and compounds modulate the GABAergic system, demonstrating different pharmacological effects. In this review, interactions of natural terpenoids with the GABAergic system are highlighted with relation to disorders like anxiety, insomnia, convulsion, pain, and cognitive deficits. Terpenoids with various structures affect the function of the GABAergic system via dissimilar mechanisms. Most of the discussed...
Source: Pharmacological Reports - April 8, 2016 Category: Drugs & Pharmacology Authors: Manayi A, Nabavi SM, Daglia M, Jafari S Tags: Pharmacol Rep Source Type: research

Therapeutic equivalence of antipsychotics and antidepressants - A systematic review.
Abstract The number of newly approved generic psychotropic drugs increases every year and, in many countries, their sales exceed the sales of brand-name counterparts. In order for any generic drug to receive an approval of regulatory authorities, its bioequivalence with the corresponding reference product must be demonstrated. Moreover, generic drugs must meet the same quality standards as reference drugs. However, many psychiatrists express concerns about use of generic drugs. We carried out a systematic analysis of the relevant literature indexed in PubMed and Cochrane databases. The MeSH term "generic" was combi...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Cessak G, Rokita K, Dąbrowska M, Rozbicka KS, Zaremba A, Mirowska-Guzel D, Bałkowiec-Iskra E Tags: Pharmacol Rep Source Type: research

The effect of lithium on hematopoietic, mesenchymal and neural stem cells.
Abstract Lithium has been used in modern psychiatry for more than 65 years, constituting a cornerstone for the long-term treatment of bipolar disorder. A number of biological properties of lithium have been discovered, including its hematological, antiviral and neuroprotective effects. In this article, a systematic review of the effect of lithium on hematopoietic, mesenchymal and neural stem cells is presented. The beneficial effects of lithium on the level of hematopoietic stem cells (HSC) and growth factors have been reported since 1970s. Lithium improves homing of stem cells, the ability to form colonies and HSC...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Ferensztajn-Rochowiak E, Rybakowski JK Tags: Pharmacol Rep Source Type: research

Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs.
Abstract The pharmacological management of insomnia has lately become a challenge for researchers worldwide. As per the third International Classification of Sleep disorders (ICSD-3) insomnia can be defined as a state with repeated difficulty in sleep initiation, duration, consolidation, or quality that occurs despite adequate opportunity and circumstances for sleep, and results in some form of daytime impairment. The conventional treatments approved for management of insomnia were benzodiazepines (BZDs) (estazolam, quazepam, triazolam, flurazepam and temazepam) and non-BZDs, also known as z-drugs (zaleplon, zolpid...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Kumar A, Chanana P, Choudhary S Tags: Pharmacol Rep Source Type: research

Neuronal nitric oxide synthase has a role in the detrimental effects of lipopolysaccharide on spatial memory and synaptic plasticity in rats.
CONCLUSION: It is suggested that inhibition of nNOS by 7NI improves the deleterious effects of LPS by reducing NO metabolites and the brain tissues oxidative damage. PMID: 26922523 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Anaeigoudari A, Soukhtanloo M, Shafei MN, Sadeghnia HR, Reisi P, Beheshti F, Behradnia S, Mousavi SM, Hosseini M Tags: Pharmacol Rep Source Type: research

Pharmacological evaluation of novel 1-[4-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea as potent anticonvulsant and antidepressant agent.
CONCLUSION: BPPU displayed broad spectrum of anticonvulsant activity in several seizure models along with satisfactory antidepressant activity. Therefore, BPPU may be further developed as a potential therapeutic agent for therapy of epileptic disorders. PMID: 26922524 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Kumari S, Mishra CB, Tiwari M Tags: Pharmacol Rep Source Type: research

Assessment of the anticonvulsant potency of various benzylamide derivatives in the mouse maximal electroshock-induced seizure threshold model.
CONCLUSION: The studied benzylamide derivatives can be arranged with respect to their anticonvulsant potency in the MEST test as follows: Nic-BZA>2F-Pic-BZA>Pic-BZA>Me-Ala-BZA>Iso-Nic-BZA>Me-Pro-BZA. PMID: 26922525 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Świąder MJ, Paruszewski R, Łuszczki JJ Tags: Pharmacol Rep Source Type: research

The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect.
Abstract Depression is a serious global illness, becoming more and more common in developed countries. Because of specific symptoms it is considered as a leading cause of disability all over the world with a high death factor due to suicides. There are many antidepressants used in the therapy, but still more than 30% of patients do not respond to the treatment. The heterogeneous nature of the illness and its complex, unclear aetiology may be responsible for these difficulties. Next to the main monoaminergic hypothesis of depression there are also many other approaches connected with the pathophysiology of the disea...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Pytka K, Podkowa K, Rapacz A, Podkowa A, Żmudzka E, Olczyk A, Sapa J, Filipek B Tags: Pharmacol Rep Source Type: research

The heat shock protein 90 inhibitor, 17-AAG, attenuates thioacetamide induced liver fibrosis in mice.
CONCLUSION: The Hsp90 inhibitor, 17-AAG, can attenuate thioacetamide hepatotoxicity through oxidative stress counterbalance, reducing stellate cells activity and inducing apoptosis. PMID: 26922527 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Abu-Elsaad NM, Serrya MS, El-Karef AM, Ibrahim TM Tags: Pharmacol Rep Source Type: research

The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice.
CONCLUSIONS: Based on this preclinical study, a special caution is advised when treating epileptic patients with combinations of phenobarbital or carbamazepine with cimetidine. PMID: 26922528 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Świąder MJ, Barczyński B, Tomaszewski M, Świąder K, Czuczwar SJ Tags: Pharmacol Rep Source Type: research

The effect of an acute and 7-day administration of magnesium chloride on magnesium concentration in the serum, erythrocytes, and brain of rats.
CONCLUSIONS: Neither the brain nor the erythrocyte showed a change in the Mg level considerably after an increase in serum Mg level induced by the acute and subchronic administration of MgCl2 solution. PMID: 26922529 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Wlaź P, Serefko A, Szopa A, Poleszak E Tags: Pharmacol Rep Source Type: research

Effect of extended olanzapine administration on POMC and neuropeptide Y mRNA levels in the male rat amygdala and hippocampus.
CONCLUSIONS: Olanzapine can affect amygdalar and hippocampal neuronal populations by the modulation of neuropeptide activity. Importantly, it may suggest the existence of an alternative mode of its action. Undoubtedly this hypothetic regulatory mechanism requires further pharmacological and neurostructural study. PMID: 26922530 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Pałasz A, Bandyszewska M, Rojczyk E, Wiaderkiewicz R Tags: Pharmacol Rep Source Type: research

Protective action of nicotinic acid benzylamide in a variety of chemically-induced seizures in mice.
CONCLUSIONS: Summing up, Nic-BZA has a wide anticonvulsant effect in different experimental epilepsy models. PMID: 26922531 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Świąder MJ, Łuszczki JJ, Paruszewski R, Świąder K, Turski WA Tags: Pharmacol Rep Source Type: research

Facilitatory effect of AM281 on recognition memory in rats.
CONCLUSION: This is the first evidence that AM281 exerts facilitatory effect on recognition memory in rats. This effect seems to be memory specific because no alterations in animals' psychomotor activity and anxiety were observed. PMID: 26922532 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Bialuk I, Winnicka MM Tags: Pharmacol Rep Source Type: research

Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.
CONCLUSION: Overall, these findings confirm the chemopreventive potential of chrysin against B(a)P induced lung cancer in Swiss albino mice. PMID: 26922533 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Kasala ER, Bodduluru LN, Barua CC, Madhana RM, Dahiya V, Budhani MK, Mallugari RR, Maramreddy SR, Gogoi R Tags: Pharmacol Rep Source Type: research

n-3 Fatty acids regulate the inflammatory-state related genes in the lung epithelial cells exposed to polycyclic aromatic hydrocarbons.
CONCLUSIONS: Supplementation with n-3 FAs resulted in changes of inflammatory-state related genes in the lung epithelial cells exposed to PAHs. The altered profile of lipid mediators from n-3 FA as well as repression of the COX-2 protein by n-3 PUFAs in A549 cells incubated with PAHs suggests anti-inflammatory and pro-resolving properties of DHA and EPA. It remains to be shown whether these pleiotropic and protective actions of n-3 FAs contribute to fish oil's therapeutic effect in asthma. PMID: 26922534 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Gdula-Argasińska J, Czepiel J, Totoń-Żurańska J, Wołkow P, Librowski T, Czapkiewicz A, Perucki W, Woźniakiewicz M, Woźniakiewicz A Tags: Pharmacol Rep Source Type: research

Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner.
CONCLUSIONS: We showed that exenatide skewed the macrophages phenotype toward anti-inflammatory phenotype and this effect is predominantly attributable to protein kinase A and to a less extent to B/Akt activation. PMID: 26922535 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Bułdak Ł, Machnik G, Bułdak RJ, Łabuzek K, Bołdys A, Belowski D, Basiak M, Okopień B Tags: Pharmacol Rep Source Type: research

Effect of resveratrol on the pharmacokinetics of fexofenadine in rats: Involvement of P-glycoprotein inhibition.
CONCLUSIONS: RSV significantly enhanced the exposure of FEX in rats likely by the inhibition of P-glycoprotein (P-gp) mediated efflux during the intestinal absorption, suggesting that there is a potential pharmacokinetic interaction between RSV and FEX. Therefore, further studies are recommended to evaluate the potential drug-phytochemical interactions in humans. PMID: 26922536 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Bedada SK, Yellu NR, Neerati P Tags: Pharmacol Rep Source Type: research

Intensive statin therapy, used alone or in combination with ezetimibe, improves homocysteine level and lipid peroxidation to a similar degree in patients with coronary artery diseases.
CONCLUSION: Our results suggest that intensive lipid-lowering therapy has a beneficial effect on certain parameters of the blood of CAD patients. PMID: 26922537 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Pytel E, Jackowska P, Chwatko G, Olszewska-Banaszczyk M, Koter-Michalak M, Kubalczyk P, Broncel M Tags: Pharmacol Rep Source Type: research

Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity.
CONCLUSION: Hesperidin decreased cisplatin-induced functional and histopathological liver damage in a dose-dependent manner without affecting its potential cytotoxic effect. PMID: 26922538 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Omar HA, Mohamed WR, Arafa EA, Shehata BA, Sherbiny GA, Arab HH, Elgendy AN Tags: Pharmacol Rep Source Type: research

Ifenprodil for prolonged spinal blockades of motor function and nociception in rats.
CONCLUSIONS: The resulting data demonstrated that ifenprodil produces a dose-dependent local anesthetic effect in spinal anesthesia. Ifenprodil shows a more sensory-selective duration of action over motor block, whereas the duration of anesthesia is significantly longer with ifenprodil than with bupivacaine. PMID: 26922539 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Chen YW, Chiu CC, Wang JN, Hung CH, Wang JJ Tags: Pharmacol Rep Source Type: research

Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats.
CONCLUSION: Two weeks of URB597 administration to DOCA-salt hypertensive rats caused an age-specific reduction in BP, HR and cardiac and renal hypertrophy and did not affect the body weight, and water and food intake. Thus, caution should be taken during studies of FAAH inhibitors because of their potential age-specific effects. PMID: 26922540 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Toczek M, Baranowska-Kuczko M, Grzęda E, Pędzińska-Betiuk A, Weresa J, Malinowska B Tags: Pharmacol Rep Source Type: research

Renoprotective effect of diosgenin in streptozotocin induced diabetic rats.
CONCLUSION: The above study justifies diosgenin as a promising candidate in diabetes associated complication through its antioxidant and anti-inflammatory activity. PMID: 26922541 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Kanchan DM, Somani GS, Peshattiwar VV, Kaikini AA, Sathaye S Tags: Pharmacol Rep Source Type: research

The preventive role of levosimendan against bleomycin-induced pulmonary fibrosis in rats.
CONCLUSIONS: The results obtained from biochemical and histopathological evaluations indicate that levosimendan had an anti-fibrotic effect without a dose-dependent response on pulmonary fibrosis. PMID: 26922542 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Gürbüzel M, Sayar I, Cankaya M, Gürbüzel A, Demirtas L, Bakirci EM, Capoglu I Tags: Pharmacol Rep Source Type: research

The molecular basis of chloroethylclonidine block of inward rectifier (Kir2.1 and Kir4.1) K(+) channels.
CONCLUSIONS: Overall, our results suggest that differences in the cavity of Kir channels are determinants in its interactions with chloroethylclonidine. PMID: 26922543 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Rodríguez-Menchaca AA, Aréchiga-Figueroa IA, Sánchez-Chapula JA Tags: Pharmacol Rep Source Type: research

Odors identification differences in deficit and nondeficit schizophrenia.
CONCLUSIONS: No overall differences between DS and NDS regarding odors identification have been found. The results seem to indicate some specific deficits in the identification of markers of rose, pineapple, orange and cinnamon. PMID: 26922544 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Pełka-Wysiecka J, Wroński M, Bieńkowski P, Murawiec S, Samochowiec A, Samochowiec J Tags: Pharmacol Rep Source Type: research

Augmentation of effect of venlafaxine by folic acid in behavioral paradigms of depression in mice: Evidence of serotonergic and pro-inflammatory cytokine pathways.
CONCLUSIONS: Combining low dose venlafaxine with an augmenting agent like folic acid, thus, appears to be an optimum strategy to increase its therapeutic efficacy and to reduce its dose. PMID: 26922545 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Thomas J, Khanam R, Vohora D Tags: Pharmacol Rep Source Type: research

Recent advances in the biomedical applications of fumaric acid and its ester derivatives: The multifaceted alternative therapeutics.
Abstract Several lines of evidence have demonstrated the potential biomedical applications of fumaric acid (FA) and its ester derivatives against many human disease conditions. Fumaric acid esters (FAEs) have been licensed for the systemic treatment of the immune-mediated disease psoriasis. Biogen Idec Inc. announced about the safety and efficacy of the formulation FAE (BG-12) for treating RRMS (relapsing-remitting multiple sclerosis). Another FAE formulation DMF (dimethyl fumarate) was found to be capable of reduction in inflammatory cardiac conditions, such as autoimmune myocarditis and ischemia and reperfusion. ...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Das RK, Brar SK, Verma M Tags: Pharmacol Rep Source Type: research

The influence of aripiprazole and olanzapine on the anxiolytic-like effect observed in prenatally stressed rats (animal model of schizophrenia) exposed to the ethyl alcohol.
CONCLUSION: ARI and OLA can reduce the level of anxiety which proves drugs effectiveness in course anxiety-like behavior. On the other hand only ARI generated anxiolytic effect in exposure to ethyl alcohol conditions. PMID: 26922547 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Ratajczak P, Kus K, Giermaziak W, Nowakowska E Tags: Pharmacol Rep Source Type: research

A novel synthetic novobiocin analog, FM-Nov17, induces DNA damage in CML cells through generation of reactive oxygen species.
CONCLUSIONS: FM-Nov17-induces DNA damage and mitochondria-dependent cellular apoptosis in CML cells. The process is mediated by the generation of ROS. PMID: 26922548 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Zhang N, Huang L, Tian J, Chen X, Ke F, Zheng M, Xu J, Wu L Tags: Pharmacol Rep Source Type: research

The effect of statin therapy on thyroid autoimmunity in patients with Hashimoto's thyroiditis: A pilot study.
CONCLUSIONS: Although 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors are able to reduce thyroid autoimmunity in women with Hashimoto's thyroiditis, intensive statin therapy is required to produce this effect. PMID: 26922549 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Krysiak R, Kowalcze K, Okopień B Tags: Pharmacol Rep Source Type: research

Role of spinal 5-HT2 receptors subtypes in formalin-induced long-lasting hypersensitivity.
CONCLUSION: Data suggest that spinal 5-HT2A/2B/2C receptors have pronociceptive effects and participate in the development and maintenance of formalin-induced long-lasting hypersensitivity. These receptors are expressed in DRG and their expression is modulated by formalin. PMID: 26922550 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Cervantes-Durán C, Vidal-Cantú GC, Godínez-Chaparro B, Granados-Soto V Tags: Pharmacol Rep Source Type: research

The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect.
Abstract Depression is one of the most common mental disorders and social issue worldwide. Although there are many antidepressants available, the effectiveness of the therapy is still a serious issue. Moreover, there are many limitations of currently used antidepressants, including slow onset of action, numerous side effects, or the fact that many patients do not respond adequately to the treatment. Therefore, scientists are searching for new compounds with different mechanisms of action. Numerous data indicate the important role of glutamatergic, GABA-ergic, and cholinergic receptors in the pathomechanism of major...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Pytka K, Dziubina A, Młyniec K, Dziedziczak A, Żmudzka E, Furgała A, Olczyk A, Sapa J, Filipek B Tags: Pharmacol Rep Source Type: research

Coadministration of tramadol with aripiprazole and venlafaxine-The effect on spatial memory functions in male rats.
CONCLUSION: It can be assumed that chronic treatment with combinations of TRM+VEN or TRM+ARI is unlikely to cause memory impairment and interfere with either any antidepressant effect of VEN or any antipsychotic effect of ARI in patients suffering from chronic pain using TRM. PMID: 26922552 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Szkutnik-Fiedler D, Kus K, Ratajczak P, Antoniów M, Nowakowska E, Grześkowiak E Tags: Pharmacol Rep Source Type: research

Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine.
CONCLUSIONS: Taken together, these results show that perifosine modified the Kv2.1 inactivation gating resulting in a decrease of the current amplitude. These data will help to elucidate the mechanism of action of this promising anti-cancer drug on ion channels and their possible implications. PMID: 26922553 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Delgado-Ramírez M, Morán-Zendejas R, Aréchiga-Figueroa IA, Toro-Castillo C, Ramírez-Martínez JF, Rodríguez-Menchaca AA Tags: Pharmacol Rep Source Type: research

Reactive oxygen species and synthetic antioxidants as angiogenesis modulators: Clinical implications.
Abstract Angiogenesis is important for normal functioning of organism and its disturbances are observed in many diseases, called angiogenesis-related states. Reactive oxygen species (ROSs) play an important role in physiology, but high level of cellular ROSs is cytotoxic and mutagenic for the cells, i.e. it can lead to oxidative stress. In this review we discuss close relationship between ROSs and angiogenesis process. Substances counteracting free radicals or their action and oxidative stress are known as antioxidants. We postulate that antioxidants, by affecting angiogenesis, may modulate therapy results in the c...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Radomska-Leśniewska DM, Hevelke A, Skopiński P, Bałan B, Jóźwiak J, Rokicki D, Skopińska-Różewska E, Białoszewska A Tags: Pharmacol Rep Source Type: research

Potential role of spinal TRPA1 channels in antinociceptive tolerance to spinally administered morphine.
CONCLUSIONS: Antinociceptive morphine tolerance and up-regulation of spinal DAAO were attenuated in morphine-treated animals by blocking the spinal TRPA1. This finding suggests that spinal TRPA1 may contribute, at least partly, to facilitation of morphine antinociceptive tolerance through mechanisms that possibly involve TRPA1-mediated up-regulation of the astroglial DAAO, a generator of hydrogen peroxide, a pronociceptive compound acting also on TRPA1. PMID: 26922555 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Wei H, Wu HY, Fan H, Li TF, Ma AN, Li XY, Wang YX, Pertovaara A Tags: Pharmacol Rep Source Type: research

Common ABCB1 polymorphisms in Greek patients with chronic hepatitis C infection: A comparison with hyperlipidemic patients and the general population.
CONCLUSION: Our findings imply an influence of ABCB1 polymorphisms on HCV infectivity, possibly through an effect on lipid homeostasis. PMID: 26922556 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Gbandi E, Goulas A, Sevastianos V, Hadziyannis S, Panderi A, Koskinas J, Papatheodoridis G, Vasiliadis T, Agapakis D, Protopapas A, Ioannidou P, Zacharakis G, Sinakos E, Koutsounas S, Germanidis G Tags: Pharmacol Rep Source Type: research

Epicutaneous (EC) immunization with type II collagen (COLL II) induces CD4(+) CD8(+) T suppressor cells that protect from collagen-induced arthritis (CIA).
CONCLUSION: Maneuver of EC immunization with a protein antigen that induces suppressor cells to inhibit inflammatory responses may become an attractive, noninvasive, needle-free therapeutic method for different clinical situations. PMID: 26922557 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Marcińska K, Majewska-Szczepanik M, Lazar A, Kowalczyk P, Biała D, Woźniak D, Szczepanik M Tags: Pharmacol Rep Source Type: research

The effect of metformin on the hypothalamic-pituitary-thyroid axis in patients with type 2 diabetes and amiodarone-induced hypothyroidism.
CONCLUSIONS: The obtained results indicate that the effect of metformin on hypothalamic-pituitary-thyroid axis activity is partially related to thyroid function. Metformin treatment may bring clinical benefits to patients with amiodarone-induced hypothyroidism and poor tolerance of exogenous l-thyroxine. PMID: 26922558 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Krysiak R, Gilowska M, Szkróbka W, Okopień B Tags: Pharmacol Rep Source Type: research

The 28-day exposure to fenpropathrin decreases locomotor activity and reduces activity of antioxidant enzymes in mice brains.
CONCLUSIONS: The decrease of SOD activity in mice brains results from direct inhibition of the enzyme by Fen and/or increased utilization due to excessive free radical formation in conditions of Fen-induced oxidative stress. The reduction in GPx activity is probably due to limited glutathione availability. The reduced locomotor activity is a behavioral demonstration of Fen-induced damage in the dopaminergic system. PMID: 26922559 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Nieradko-Iwanicka B, Borzęcki A Tags: Pharmacol Rep Source Type: research

Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione.
CONCLUSIONS: 3-BP reacts with GSH in the absence of cells and intracellularly. This reaction appears to be the main cause of GSH loss in 3-BP treated cells. PMID: 26922560 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Sadowska-Bartosz I, Szewczyk R, Jaremko L, Jaremko M, Bartosz G Tags: Pharmacol Rep Source Type: research

Imatinib reduces cholesterol uptake and matrix metalloproteinase activity in human THP-1 macrophages.
CONCLUSION: Our results indicate that imatinib causes post-translational inhibition with respect to cholesterol uptake and regulation of MMP-2 and MMP-9. More research is needed to further evaluate the role of imatinib in the regulation of other genes and processes. PMID: 26721343 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Gacic J, Vorkapic E, Olsen RS, Söderberg D, Gustafsson T, Geffers R, Skoglund K, Matussek A, Wågsäter D Tags: Pharmacol Rep Source Type: research

β-Elemene induces apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase.
CONCLUSIONS: Taken together, β-elemene is effective in inducing mitochondrial apoptosis of RA-FLS, which is mediated through induction of ROS formation and p38 MAPK activation. β-Elemene may thus have therapeutic benefits for RA. PMID: 26721344 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Zou S, Wang C, Cui Z, Guo P, Meng Q, Shi X, Gao Y, Yang G, Han Z Tags: Pharmacol Rep Source Type: research

Enhanced pretreatment CD25 expression on peripheral blood CD4+ T cell predicts shortened survival in acute myeloid leukemia patients receiving induction chemotherapy.
CONCLUSIONS: Our data indicate that quantification of CD25 expression on peripheral blood CD4+ T cells could become a novel, easily accessible method of shortened survival prognostication of AML patients subjected to standard cytotoxic therapy. PMID: 26721345 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Bołkun Ł, Rusak M, Eljaszewicz A, Pilz L, Radzikowska U, Łapuć I, Łuksza E, Dąbrowska M, Bodzenta-Łukaszyk A, Kłoczko J, Moniuszko M Tags: Pharmacol Rep Source Type: research

TBBPA causes neurotoxic and the apoptotic responses in cultured mouse hippocampal neurons in vitro.
CONCLUSION: We suggest that the H2DCFDA assay cannot be used to measure TBBPA-stimulated cell-mediated ROS production. PMID: 26721346 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Szychowski KA, Wójtowicz AK Tags: Pharmacol Rep Source Type: research

β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity.
CONCLUSION: Although, it remains unclear how β-lapachone induces MRN complex expression, our findings suggest that β-lapachone might affect MRN complex expression and participate in DNA damage recovery in cisplatin-induced nephrotoxicity. PMID: 26721347 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Kim TW, Kim YJ, Kim HT, Park SR, Jung JY Tags: Pharmacol Rep Source Type: research

Mixed MOP/DOP agonist biphalin elicits anti-transit effect in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms.
CONCLUSION: Biphalin is an interesting template for novel opioid-based agents to be used in therapy of functional GI diseases. PMID: 26721348 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Zielińska M, Jarmuż A, Sałaga M, Lipkowski AW, Fichna J Tags: Pharmacol Rep Source Type: research

Hydrogen sulfide inhibits endothelial nitric oxide formation and receptor ligand-mediated Ca(2+) release in endothelial and smooth muscle cells.
CONCLUSIONS: H2S antagonized Ca(2+) mobilization by receptor agonists and store-operated Ca(2+) entry thereby limiting eNOS activation and NO formation. The effect of H2S on Ca(2+) stores was not restricted to endothelial cells but was also observed in vascular and tracheal smooth muscle cells. PMID: 26721349 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Kloesch B, Steiner G, Mayer B, Schmidt K Tags: Pharmacol Rep Source Type: research