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What is the Remission Rate for Antithyroid Drug Treatment for Hyperthyroidism in Children?
Discussion The thyroid gland secrets two hormones – T4 which is a prohormone and T3 which is the biologically active hormone. Receptors for T3 are found in nearly all body tissues. T3 regulates metabolism and energy production. Organs most affected are the heart, liver and central nervous system as well as growth of the fetus and child. Hyperthyroidism is common with a prevalence rate of about 1-2% for women and 0.2% for men. The most common cause of thyrotoxicosis is Grave’s disease where autoantibodies to thyroid stimulating hormone (TSH) exist. These autoantibodies attach to thyroid tissue TSH receptors and...
Source: PediatricEducation.org - January 26, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Infected tracheal diverticulum: a rare association with alpha-1 antitrypsin deficiency
We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy fail...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

A six-minute step test protocol for the investigation of dyspnea
We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy fail...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Preserving the intercostal nerves as a goal in thoracotomy
We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy fail...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Thyroid nodules and thyroid cancer in Graves’ disease
Conclusions Especially Graves’ patients who have been decided to be followed up should be evaluated carefully during the follow-up in terms of thyroid cancer which may accompany. Arq Bras Endocrinol Metab. 2014;58(9):933-8 Objetivo A frequência da ocorrência de nódulos tiroidianos acompanhando a doença de Graves e o risco de câncer de tiroide na presença desses nódulos é controversa. O objetivo deste estudo foi avaliar a frequência de nódulos tiroidianos e o risco de câncer de tiroide em pacientes operados por doença de Graves. Sujeitos ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 25, 2015 Category: Endocrinology Source Type: research

Large thyroid cyst in a patient with congenital hypothyroidism
We describe a case of hypothyroidism due to dyshormonogenesis whose one of the previously solid nodules degenerates into a large cyst. A 22-year-old male was referred to our clinic for evaluation of enlarging thyroid nodule. Hypothyroidism was diagnosed in infancy, however due to poor compliance to treatment TSH values were elevated most of the times. When he was fifteen the first nodule was detected which was a solid cold nodule. Fine needle aspiration was in favor of benign follicular nodule. Seven years later we found a large multi nodular thyroid with a predominant large cyst correspo...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 25, 2015 Category: Endocrinology Source Type: research

A case of thyroid hormone resistance: a rare mutation
We describe a 67-years old, Caucasian woman, with past history of subtotal thyroidectomy due to diffuse goiter, who presents with a recurrence of goiter. Although she is clinically euthyroid, laboratory evaluation shows persistent hyperthyroxinemia with non-suppressed TSH. Response to thyrotropin releasing hormone (TRH) test was normal and TSH concentrations were not suppressed during oral administration of suprafisiologic doses of levothyroxine (L-T4). Peripheral blood DNA was extracted from the patient and a mutation was found localized in cluster one, at codon 346 of the ligand binding...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 25, 2015 Category: Endocrinology Source Type: research

Aortic stiffness and left ventricular function in patients with differentiated thyroid cancer
Conclusion Long-term thyrotropin-suppression therapy has continuous adverse effects on the arterial wall. The degree of TSH suppression in patients with DTC should be kept at the possible minimum, based on individually determined potential benefits and risks of treatment, especially in patients with cardiovascular co-morbidities. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 24, 2015 Category: Endocrinology Source Type: research

Hypocalcaemia after total thyroidectomy: Could intact parathyroid hormone be a predictive factor for transient postoperative hypocalcemia?
Hypocalcemia, the most common complication of thyroidectomy, is a transient condition in up to 27% of patients and a permanent condition approximately 1% of patients. The aim of this prospective study was to evaluate reliability of postoperative intact parathyroid hormone (iPTH) assessment for predicting clinically relevant postthyroidectomy hypocalcemia for a safe early discharge of patients with no overtreatment. (Source: Surgery)
Source: Surgery - January 23, 2015 Category: Surgery Authors: Alessandro Puzziello, Rita Gervasi, Giulio Orlando, Nadia Innaro, Mario Vitale, Rosario Sacco Tags: Endocrine Source Type: research

Quality of life in patients with benign non-toxic goiter: impact of disease, treatment response, and comparison with the general population.
Conclusions</b> Compared with the general population, patients with NTG had greatest HRQoL impairment at baseline on the Goiter Symptoms and Anxiety scales, which also demonstrated the largest post-treatment improvements. However, both disease-specific and generic HRQoL deficits persisted 6 months after treatment. In order to improve individualized care, future studies should focus on identifying risk factors for persistent HRQoL deficits and compare HRQoL effects of the various goiter treatment modalities in relation to thyroid phenotype. PMID: 25602312 [PubMed - as supplied by publisher] (Source: Thyroid : offi...
Source: Thyroid : official journal of the American Thyroid Association - January 21, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

Importance of in situ preservation of parathyroid glands during total thyroidectomy
ConclusionIn situ parathyroid preservation is critical in preventing permanent hypoparathyroidism after total thyroidectomy. Active medical treatment of postoperative hypocalcaemia has a positive synergistic effect. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 20, 2015 Category: Surgery Authors: L. Lorente‐Poch, J. J. Sancho, S. Ruiz, A. Sitges‐Serra Tags: Original article Source Type: research

Importance of in situ preservation of parathyroid glands during total thyroidectomy.
CONCLUSION: In situ parathyroid preservation is critical in preventing permanent hypoparathyroidism after total thyroidectomy. Active medical treatment of postoperative hypocalcaemia has a positive synergistic effect. PMID: 25605285 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - January 20, 2015 Category: Surgery Authors: Lorente-Poch L, Sancho JJ, Ruiz S, Sitges-Serra A Tags: Br J Surg Source Type: research

Radioiodine Uptake in an Ovarian Mature Teratoma Detected With SPECT/CT
Abstract: A 28-year-old woman underwent a near-total thyroidectomy for papillary carcinoma. Before radioiodine therapy, the serum thyroid-stimulating hormone level was 50 μIU/mL, the thyroglobulin level was 1 μg/L, and the antithyroglobulin was negative. She received 100 mCi of 131I for ablation of residual thyroid tissue. After therapy, 131I whole-body scan demonstrated focal uptake in the right pelvic area, which localized to the right ovary on SPECT/CT fusion images. The ovarian cyst was resected, and histopathological examination revealed a mature teratoma without thyroid tissue component. At 6-month follow-up, the w...
Source: Clinical Nuclear Medicine - January 19, 2015 Category: Radiology Tags: Interesting Images Source Type: research

123I Accumulation in Thoracic Neoesophagus Masking Residual Papillary Thyroid Cancer
Abstract: A 56-year-old woman with prior esophageal resection and reconstruction after accidental lye ingestion presented for management of recently diagnosed thyroid cancer. She had total thyroidectomy with pathology demonstrating bilateral well-differentiated papillary thyroid cancer measuring up to 1.0 cm and positive margins. Approximately 1 month after surgery, 123I whole-body scan was obtained. Planar images demonstrated linear 123I uptake in the thorax, compatible with accumulation in the neoesophagus. Given the patient’s postsurgical anatomy, SPECT/CT of the thorax was done and demonstrated additional focal 123I ...
Source: Clinical Nuclear Medicine - January 19, 2015 Category: Radiology Tags: Interesting Images Source Type: research

FDG PET/CT of Neuroendocrine Carcinoma of the Thyroid Gland
Abstract: Neuroendocrine carcinoma of the thyroid gland is very rare and difficult to diagnose preoperatively. Hereby we describe a case of neuroendocrine carcinoma of the thyroid that showed intense FDG activity on PET/CT in a 61-year-old woman who had partial thyroidectomy 5 years ago for a suspicious thyroid nodule that was diagnosed as neurofibroma pathologically. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - January 19, 2015 Category: Radiology Tags: Interesting Images Source Type: research

Feasibility of ultrasound-guided capsule-sheath space block combined with anterior cervical cutaneous nerves block for thyroidectomy: an observational pilot study
Conclusions: Combining ultrasound-guided CSSB and CCNB is a feasible, effective and safe technique for thyroidectomy.Trial registration: Current Controlled Trials ChiCTR-ONC-12002025. Registered 19 March 2012. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - January 19, 2015 Category: Anesthesiology Authors: Quanguang WangZhengqian LiShihao XuYu LiXuezheng ZhangQimin LiuYun XiaThomas PapadimosXuzhong Xu Source Type: research

Minimally invasive video assisted thyroidectomy (MIVAT) and papillary thyroid carcinoma
Publication date: January 2015 Source:European Journal of Surgical Oncology (EJSO), Volume 41, Issue 1 Author(s): L. Viani , P. Del Rio , M. Sianesi (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - January 19, 2015 Category: Surgery Source Type: research

Does intraoperative nerve monitoring reliably aid in staging of total thyroidectomies?
ConclusionsIntraoperative nerve monitoring results accurately indicated postoperative ipsilateral vocal cord dysfunction with high reliability. Intraoperative nerve monitoring is a reliable tool in staging thyroid surgery. Level of Evidence4. Laryngoscope, 2015 (Source: The Laryngoscope)
Source: The Laryngoscope - January 19, 2015 Category: ENT & OMF Authors: Tatyana E. Fontenot, Gregory W. Randolph, Tedhar E. Setton, Nuha Alsaleh, Emad Kandil Tags: Thyroid/Parathyroid Source Type: research

Fetus dose estimation in thyroid cancer post-surgical radioiodine therapy
Unrecognised pregnancy during radioisotope therapy of thyroid cancer results in hardly definable embryo/fetus exposures, particularly when the thyroid gland is already removed. Sources of such difficulty include uncertainty in data like pregnancy commencing time, amount and distribution of metastasized thyroid cells in body, effect of the thyroidectomy on the fetus dose coefficient etc. Despite all these uncertainties, estimation of the order of the fetus dose in most cases is enough for medical and legal decision-making purposes. A model for adapting the dose coefficients recommended by the well-known methods to the probl...
Source: Radiation Protection Dosimetry - January 19, 2015 Category: Radiology Authors: A. Mianji, F., Karimi Diba, J., Babakhani, A. Tags: Papers Source Type: research

Preoperative TSH level and risk of thyroid cancer in patients with nodular thyroid disease: nodule size contribution
Conclusions Our study supported an association between preoperative TSH levels and risk of DTC in patients with NTD. There was also a direct relationship between malignant nodule size and TSH levels. By contrast, no relationship was found between the size of benign nodules and TSH levels. (Source: Endocrinologia y Nutricion)
Source: Endocrinologia y Nutricion - January 18, 2015 Category: Endocrinology Source Type: research

Body Weight Changes in Patients Subjected to ThyroidectomyBody Weight Changes in Patients Subjected to Thyroidectomy
Is significant weight gain associated with thyroidectomoy limited to patients with Graves disease? Endocrine Practice (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 16, 2015 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Angiogenesis in primary hyperparathyroidism
Angiogenesis can be described as a formation of new vessels from the existing microvasculature and is a process of great importance to the tumor development. Parathyroid tissue can trigger spontaneous induction of angiogenesis in vitro and in vivo models in a vascular endothelial growth factor (VEGF)-dependent manner. Autotransplantated parathyroid tissue after thyroidectomy is able to form new vasculature and produce parathormone, maintaining calcium homeostasis. A great amount of factors contributes to the process of new vessel formation in primary hyperparathyroidism, such as vascular endothelial growth factor, transfor...
Source: Annals of Diagnostic Pathology - January 16, 2015 Category: Pathology Authors: Oliwia Anna Segiet, Marek Michalski, Marlena Brzozowa, Adam Piecuch, Małgorzata Żaba, Krzysztof Helewski, Andrzej Gabriel, Romuald Wojnicz Source Type: research

Co-existent thyroid disease in patients treated for primary hyperparathyroidism: implications for clinical management
In conclusion, synchronous thyroid surgery was required in 29 % of all parathyroidectomy procedures performed for treatment of primary hyperparathyroidism with malignant thyroid lesions incidentally detected in 14 % of cases. Less than half of all confirmed concomitant thyroid pathology had been referred to or recognised on pre-operative radiology studies. These findings highlight the importance of considering the potential need to perform thyroid surgery during parathyroidectomy and obtaining appropriate informed consent. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - January 15, 2015 Category: ENT & OMF Source Type: research

Follicular variant papillary thyroid carcinoma with a twist
Conclusion Skin metastasis from papillary and follicular thyroid carcinoma is an uncommon occurrence and these lesions should be differentiated from primary skin tumors. They are very important to recognize as early recognition can lead to accurate and prompt diagnosis leading to timely treatment. The scalp has been found to be the commonest site of cutaneous metastasis that may appear benign. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - January 15, 2015 Category: Surgery Source Type: research

Total thyroidectomy for giant goiter under local anesthesia and Ketamine in a surgical mission
Conclusion Total thyroidectomy for giant goiters can be done under local anesthesia with Ketamine and proper sedation. Surgeons and anesthesiologists participating in surgical missions may have to perform major surgery under local anesthesia. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - January 15, 2015 Category: Surgery Source Type: research

Parathyroid Gland Autotransplantation after Total Thyroidectomy in Surgical Management of Hypopharyngeal and Laryngeal Carcinomas: A Case Series
Conclusions Parathyroid gland autotranplantation is a simple safe technique with high success rate in preventing persistent hypoparathyroidism after total thyroidectomy in surgical management of advanced hypopharyngeal and laryngeal carcinomas. (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - January 15, 2015 Category: Journals (General) Source Type: research

Prophylactic central compartment lymph node dissection in papillary thyroid carcinoma: clinical implications derived from the first prospective randomized controlled single institution study.
Conclusions: cN0 PTC patients treated either with TTx or TTx+pCCND showed a similar outcome. One advantage of TTx+pCCND was a reduced need to repeat 131-I treatments, but the disadvantage was a higher prevalence of permanent hypoparathyroidism. Almost 50% of PTC patients had micrometastatic lymph nodes in the central compartment, but none of the presurgical features analyzed, including BRAF mutation, was able to predict their presence; moreover, to be aware of their presence does not appear to have any impact on the outcome. PMID: 25590215 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 15, 2015 Category: Endocrinology Authors: Viola D, Materazzi G, Valerio L, Molinaro E, Agate L, Faviana P, Seccia V, Sensi E, Romei C, Piaggi P, Torregrossa L, Sellari-Franceschini S, Basolo F, Vitti P, Elisei R, Miccoli P Tags: J Clin Endocrinol Metab Source Type: research

Kikuchi-Fujimoto Disease Masquerading as Metastatic Papillary Carcinoma of the Thyroid
We present an unusual case of Kikuchi-Fujimoto disease masquerading as metastatic papillary carcinoma of the thyroid.A 30-year-old young female presented, 2 months post-partum, with complaints of neck pain and fever. A computed tomography scan showed enlarged right-sided lymph nodes and a thyroid nodule. Subsequent biopsy of a thyroid nodule revealed papillary thyroid carcinoma and reactive inflammation in one of the lymph nodes. She underwent an elective total thyroidectomy, central node dissection and a right modified lymph node dissection for enlarged lymph nodes. Her recovery was uneventful and the pathology report was...
Source: International Journal of Angiology - January 14, 2015 Category: Cardiology Authors: Garg, ShaileshVilla, ManuelAsirvatham, Jaya RuthMathew, ThomasAuguste, Louis-Joseph Tags: Case Report Source Type: research

Electrophysiologic identification and monitoring of the external branch of superior laryngeal nerve during thyroidectomy
ConclusionEBSLN is less likely to be visualized in obese patients; however, there was no gender or racial disparity. Stimulation of EBSLN was felt to be a useful adjunct during superior pole dissection to assure the nerve integrity. Level of Evidence4. Laryngoscope, 2015 (Source: The Laryngoscope)
Source: The Laryngoscope - January 13, 2015 Category: ENT & OMF Authors: Emad Kandil, Salah Eldin Mohamed, Ahmed Deniwar, Hossam Mohamed, Paul Friedlander, Rizwan Aslam, Ahmed Saeed, Ibrahim Musa, Gregory Randolph Tags: Thyroid/Parathyroid Source Type: research

Surgical management of hyperthyroidism
Conclusion Surgical management of hyperthyroidism enables good endocrinal control if surgery is complete. Patients need to be fully informed of all possible postoperative complications that could occur, especially vocal ones. Long-term follow-up is necessary to detect recurrence, which can occur more than 20 years after partial thyroidectomy surgery. Surgery allows early diagnosis of 12.5% of papillary carcinomas. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - January 13, 2015 Category: ENT & OMF Source Type: research

Innervation of the cricothyroid muscle by the recurrent laryngeal nerve
Conclusions: The RLN innervated the CTM at least in 39% cases. This article is protected by copyright. All rights reserved. (Source: Head and Neck)
Source: Head and Neck - January 12, 2015 Category: ENT & OMF Authors: Hiroo Masuoka, Akira Miyauchi, Tomonori Yabuta, Mitsuhiro Fukushima, Akihiro Miya Tags: Original Article Source Type: research

Frequency and Pattern of Central Lymph Node Metastasis in Papillary Carcinoma of the Thyroid Isthmus
Conclusion. Complete bilateral CND should be considered for isthmic PTC due to the high rate of bilateral CLNM, especially to pretracheal and bilateral paratracheal lymph nodes. This article is protected by copyright. All rights reserved. (Source: Head and Neck)
Source: Head and Neck - January 12, 2015 Category: ENT & OMF Authors: Chang Myeon Song, Dong Won Lee, Yong Bae Ji, Jin Hyeok Jeong, Jung Hwan Park, Kyung Tae Tags: Original Article Source Type: research

Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility
In this study, we report new, unrelated Brazilian individuals with germline RET Y791F-only: two tumour-free elderly controls; two individuals with sporadic MTC whose Y791F-carrying relatives did not show any evidence of tumours; and a 74-year-old phaeochromocytoma patient without MTC. Furthermore, we showed that the co-occurrence of Y791F with the strong RET C634Y mutation explains the aggressive MTC phenotypes observed in a large affected family that was initially reported as Y791F-only. Our literature review revealed that limited analyses have led to the misclassification of RET Y791F as a probable pathogenic variant and...
Source: Endocrine-Related Cancer - January 12, 2015 Category: Endocrinology Authors: Toledo, R. A., Hatakana, R., Lourenco, D. M., Lindsey, S. C., Camacho, C. P., Almeida, M., Lima, J. V., Sekiya, T., Garralda, E., Naslavsky, M. S., Yamamoto, G. L., Lazar, M., Meirelles, O., Sobreira, T. J. P., Lebrao, M. L., Duarte, Y. A. O., Blangero, J Tags: Research Source Type: research

Pathology of Thyroglossal Duct: an Institutional Experience
In conclusion, we report an institutional case cohort of 242 patients with TGD-associated lesions, including 217 TGDC and 18 cases of PTC. Only seven cases fulfilled the diagnostic criteria of TGD-associated PTC, i.e., the presence of components of TGD and a normal thyroid. In the remaining 11 cases, we could not differentiate with certainty between pyramidal primary thyroid PTC/Delphian node metastasis or TGD-associated PTC. (Source: Endocrine Pathology)
Source: Endocrine Pathology - January 11, 2015 Category: Pathology Source Type: research

How uncomplicated total thyroidectomy could aggravate the laryngopharyngeal reflux disease?
Abstract Swallowing, voice disorders, throat discomfort and subjective neck discomfort are usually reported by patients with a known thyroid nodule and are correlated to nodular thyroid disease itself. Moreover, in endemic goitrous areas, total thyroidectomy (TT) is the most frequently performed surgical procedure. We are used to relate swallowing, voice and throat discomfort to the mechanical effects of nodular goiter or to thyroidectomy itself, but in both these cases the relationship between symptoms and the thyroid mass or its removal is not always clear or easily demonstrated. How can we explain the persisten...
Source: European Archives of Oto-Rhino-Laryngology - January 8, 2015 Category: ENT & OMF Source Type: research

Salivary Gland Dysfunction after Radioactive Iodine (I-131) Therapy in Patients following Total Thyroidectomy: Emphasis on Radioactive Iodine Therapy dose
The purpose of this study was to retrospectively evaluate symptoms, images of salivary gland dysfunction, and related clinical factors in thyroid cancer patients with total thyroidectomy followed by radioiodine therapy (RIT). (Source: Clinical Imaging)
Source: Clinical Imaging - January 6, 2015 Category: Radiology Authors: Han Na Lee, Ji Young An, Kyung Mi Lee, Eui Jong Kim, Woo Suk Choi, Deog Yoon Kim Source Type: research

Prognostic factors of follicular thyroid carcinoma
Conclusions In follicular carcinoma, rates of disease-free patients are 71% at 5 years and 58% at 10 years, and the main predictive factors are presence of local clinical symptoms and infiltration into neighboring structures. (Source: Endocrinologia y Nutricion)
Source: Endocrinologia y Nutricion - January 3, 2015 Category: Endocrinology Source Type: research

Computed tomography features of incidentally detected diffuse thyroid disease.
Conclusion. Neck CT may be helpful for the detection of incidental DTD. PMID: 25548565 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 1, 2015 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Robotic Excision of a Huge Parathyroid Adenoma via a Retroauricular Approach
AbstractPrimary hyperparathyroidism results from the overproduction of parathyroid hormone by 1 or more autonomously hyperfunctioning parathyroid glands and often causes hypercalcemia. Once this condition has been diagnosed, the treatment of choice is surgical removal. There have been many attempts to remove the hyperfunctioning gland with minimally invasive surgical techniques, with cure rates comparable with those of conventional techniques. On the basis of our initial surgical experiences of robotic thyroidectomy and other head and neck surgeries via a retroauricular (RA) approach, we have recently successfully performe...
Source: Journal of Craniofacial Surgery - January 1, 2015 Category: Surgery Tags: Brief Clinical Studies Source Type: research

A case of rapidly progressing primary thyroid angiosarcoma in a Japanese man
We describe a Japanese case of primary angiosarcoma of the thyroid in a 64-year-old man, who presented with a rapidly enlarging painful neck mass. Fine-needle aspiration biopsy was performed, and the results were interpreted as malignant. FDG-PET-CT demonstrated a necrotic lesion on the right side of the neck with high FDG uptake. The patient underwent a total thyroidectomy. Pathological findings revealed a proliferation of atypical cells lined vascular spaces. Immunohistochemistry staining (IHCS) was positive for factor VIII, and CD31, but not CD34, and negative for CK 5, CK 7, and CK 20. From these findings, it was diagn...
Source: International Cancer Conference Journal - January 1, 2015 Category: Cancer & Oncology Source Type: research

A case of synchronous thyroid metastasis from esophageal squamous cell carcinoma
We report herein a case of synchronous thyroid metastasis of esophageal squamous cell carcinoma. A 54-year-old man with lower thoracic esophageal cancer and left thyroid tumor was admitted to our hospital. We diagnosed synchronous double cancer comprising esophagus squamous cell carcinoma and thyroidal papillary cancer. Simultaneous excision of both tumors after neoadjuvant chemoradiotherapy to the esophageal cancer was planned. Intraoperatively, thyroid tumor and cervical lymph nodes were pathologically diagnosed as metastases of esophageal cancer. We then converted the treatment strategy to perform total thyroidectomy, m...
Source: Esophagus - January 1, 2015 Category: Gastroenterology Source Type: research

What happens in a 5-year follow-up of benign thyroid nodules.
Authors: Negro R Abstract To determine an optimal time for follow-up of benign thyroid nodules, we retrospectively evaluated 249 euthyroid patients with uni-multinodular goiter, who underwent annual visit, and significant events that occurred in 5 years' time were registered. A significant event (appearance of new nodule, increase of nodule diameter >50%, appearance of compressive symptoms, thyroidectomy, repetition of FNA on the same nodule, and execution of FNA on new nodule) occurred in 26.1% of patients, with more than one event occurring in the same patient in 27.7% of cases. The majority of events (71.9%) ...
Source: Journal of Thyroid Research - December 31, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Minimum alveolar concentration threshold of sevoflurane for postoperative dream recall.
CONCLUSIONS: BIS--guided anaesthesia was not able to generate different MAC values compared to HP--guided anaesthesia. Independent of the guide used for anaesthesia, a sevoflurane MAC over 0.9 was required to prevent postoperative dream recall. PMID: 25532493 [PubMed - as supplied by publisher] (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - December 29, 2014 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Reprint of: Stimulated thyroglobulin levels after thyroidectomy could guide the need for radioactive iodine ablation in patients with well differentiated thyroid cancer
Publication date: December 2014 Source:European Journal of Surgical Oncology (EJSO), Volume 40, Issue 12 Author(s): T. Cvasciuc , D. Maccora , G. Sadler , B. Shine , A. Weaver , R. Mihai (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - December 29, 2014 Category: Surgery Source Type: research

Comparison of the Incidence of Postoperative Hypocalcemia following Total Thyroidectomy vs Completion Thyroidectomy
Conclusion The risk of transient of hypocalcemia in patients undergoing CT is significantly lower than the rate of hypocalcemia in patients undergoing TT. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - December 29, 2014 Category: ENT & OMF Authors: Merchavy, S., Marom, T., Forest, V.-I., Hier, M., Mlynarek, A., McHugh, T., Payne, R. Tags: Endocrine Surgery Source Type: research

Malignant Glomus Tumor of the Thyroid Gland Where Is Heretofore an Unreported Organ: a Case Report and Literature Review
Abstract Glomus tumors are relatively uncommon clinically benign tumors. Malignant glomus tumors are rare, and only a small number develop metastatic foci. The usual location is deep dermis or subcutis, but it has been reported in various locations. A 55-year-old man presented with an incidentally found thyroid mass. Neck ultrasound showed a mass with a heterogeneous hypoechoic calcific mass in the right lobe. Right lobectomy specimen showed the 3.6-cm-sized calcified mass composed of sheets of uniform round to polygonal cells and intervening staghorn-shaped vessels. Occasional cellular atypism and necrosis with i...
Source: Endocrine Pathology - December 27, 2014 Category: Pathology Source Type: research

Long-term outcomes of observation for clinically negative central compartment lymph nodes in papillary thyroid carcinoma
We report the long-term outcomes of a series of cases treated with thyroidectomy without prophylactic central neck dissection. We reviewed 1,397 cases with papillary thyroid carcinoma treated at our institution between 1991 and 2000. One hundred and seventy-two newly diagnosed cases underwent observation for cN0 central neck lymph nodes. Regional recurrence of the ipsilateral side including central compartment and the lateral neck which needs reoperation was considered as key point for analysis. With a mean follow-up of 96.4 months (34–204 months), the overall 10-year disease-specific and recurrence-free survival rates...
Source: European Archives of Oto-Rhino-Laryngology - December 24, 2014 Category: ENT & OMF Source Type: research

Risk Factors for Recurrence of Papillary Thyroid Carcinoma with Clinically Node-Positive Lateral Neck
Conclusions Maximal size of metastatic foci, ATA risk categories, and stimulated serum Tg levels are predictive of recurrence after surgery. Careful follow-up of patients with these risk factors is therefore recommended. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 23, 2014 Category: Cancer & Oncology Source Type: research

Robotic thyroidectomy outcomes better in high-volume centers
Read the full story on MD Consult: Robotic thyroidectomy outcomes better in high-volume centers (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - December 23, 2014 Category: Journals (General) Source Type: news

Necessity for additional incisions with the cervical Collar incision to remove retrosternal goiters
Retrosternal goiters (RSGs) can be removed transcervically but additional incisions are sometimes necessary. We planned the factors determining the need for additional incisions to remove an RSG goiter based on our experience and on an algorithm.Between 2006-2013 additional incisions were needed in 20 patients with RSG in whom collar excision was not successful. Partial sternotomy was performed in 5 patients, total sternotomy in 13 and thoracotomy in 2. Vocal cord paralysis was detected in 1 patient at admission to the clinic and was occurred in 2 patients due to the operation. Tracheal laseration was occurred in 1 patient...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Mehmetoglu, S. S., Akgul, A. G., Topcu, S., Ozbay, S., Sezer, H. F., Liman, S. T., Canturk, Z., Utkan, Z. Tags: 8.1 Thoracic Surgery Source Type: research