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Carbon nanoparticles‐guided central lymph node dissection in clinically node‐negative patients with papillary thyroid carcinoma
Conclusions: CNs can be applied to more accurately guide the dissection of lymph node during thyroidectomy in PTC patients. This article is protected by copyright. All rights reserved. (Source: Head and Neck)
Source: Head and Neck - March 31, 2015 Category: ENT & OMF Authors: Youzhi Zhu, Xiangjin Chen, Huihao Zhang, Ling Chen, Shujun Zhou, Kunlin Wu, Zongcai Wang, Lingjun Kong, Hezhu Zhuang Tags: Original Article Source Type: research

Variation in Cost of Total Thyroidectomy Across the United States, 2007-2008
Conclusions More than a quarter of the variation in cost of TT was not explained by patient-, hospital- or state-level factors. Further research is needed to understand the unexplained residual variation. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - March 29, 2015 Category: Surgery Source Type: research

Thyroid Cancer in Patients with Toxic Nodular Goiter, Is the Incidence Increasing?
Conclusions No significant increase in the rate of carcinoma was observed in patients with TNG. As a result, the risk benefit analysis should not change when considering therapeutic options for TNG. Teaser The purpose of this study was to determine if there has been an increase in the incidence of thyroid cancer in patients operated on for TNG. Patients who underwent thyroidectomy for TNG were identified from a prospectively-maintained thyroid database and rates of malignancy were compared during the intervals from 1990-1999, 2000-2009 and 2010-2014. Overall, seven (4.7%) of 148 patients were found to have thyroid cancer, ...
Source: The American Journal of Surgery - March 29, 2015 Category: Surgery Source Type: research

Using diffusion-weighted MRI to predict aggressive histological features in papillary thyroid carcinoma: a novel tool for pre-operative risk stratification in thyroid cancer.
CONCLUSION: ADC value derived from DW-MRI before surgery has the potential to stratify ETE in patients with PTCs. PMID: 25809949 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 28, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

Effects of Salivary Secretion Stimulation on the Treatment of Chronic Radioacive iodine-induced Sialadenitis.
CONCLUSION: The study shows that salivary stimulation therapy may reduce the subjective symptoms of RAI-induced chronic sialadenitis but does not significantly induce functional restoration. PMID: 25809840 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 28, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

Support Needs and Survivorship Concerns of Thyroid Cancer Patients.
CONCLUSION: TC patients place high importance on most types of information and concerns. However, many needs are unmet, which varies based on demographic and treatment factors as well as the importance placed on each of the categories of information and support. PMID: 25809716 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 28, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

[Case Report] A pregnant woman with acute cardiorespiratory failure: dengue myocarditis
In April, 2014, a 29-year-old Vietnamese woman, 31 weeks into her fourth pregnancy, presented to a clinic in Ho Chi Minh City with a 2 day history of fever, dry cough, chest pain, and shortness of breath. She had a history of partial thyroidectomy for hyperthyroidism in 2012, and had had three miscarriages. She took 150 μg thyroxine daily and was a non-smoker. (Source: LANCET)
Source: LANCET - March 27, 2015 Category: Journals (General) Authors: Thuy Duong Bich, Oanh Kieu Nguyet Pham, Duong Ha Thi Hai, Nguyet Minh Nguyen, Hao Nguyen Van, Trung Dinh The, Bridget Wills, Sophie Yacoub Tags: Case Report Source Type: research

Variation in Cost of Total Thyroidectomy Across the United States, 2007-2008
Variation in cost of surgical care across state lines is poorly understood. We sought to examine state-level variation in wage-adjusted total cost (WATC) of a common surgical procedure. (Source: American Journal of Surgery)
Source: American Journal of Surgery - March 27, 2015 Category: Surgery Authors: Caroline E. Reinke, Elizabeth M. Sonnenberg, Giorgos C. Karakousis, Douglas L. Fraker, Rachel R. Kelz Source Type: research

Thyroglobulin in differentiated thyroid cancer
Publication date: 15 April 2015 Source:Clinica Chimica Acta, Volume 444 Author(s): Carol Evans , Sarah Tennant , Petros Perros Identification of differentiated thyroid cancer (DTC) is becoming increasingly common. Patients usually have an excellent prognosis. Most undergo total thyroidectomy, radioiodine ablation and treatment with suppressive doses of levothyroxine. Patients require long term follow-up which includes measurement of serum thyroglobulin (Tg). Interpretation of serum Tg requires knowledge of the concurrent thyroid stimulating hormone (TSH) concentration, as secretion is TSH dependant, and an awareness of t...
Source: Clinica Chimica Acta - March 26, 2015 Category: Laboratory Medicine Source Type: research

Unusual Metastasis of Papillary Thyroid Carcinoma: Lumbar Vertebrae
A 52-years-old woman presented to the neurosurgery clinic with lumbago and prior history of a thyroidectomy for papillary thyroid carcinoma. Magnetic resonance imaging (MRI) revealed an expansive mass in the L5 vertebra that expanded vertebral body contour and narrowed spinal canal posteriorly (figure 1,2). The mass was hyperintens on T2weighted (T2W) and T1 weighted (T1W) images (figure 1,2) and homogenous with contrast enhancement (figure 1,2). There was also a right iliac mass with similar characteristics (figure 2). (Source: The Spine Journal)
Source: The Spine Journal - March 26, 2015 Category: Orthopaedics Authors: Leyla Karaca, Recep Sade, Ihsan Yuce, Hayri Ogul, Mecit Kantarci Tags: Images of Spine Care Source Type: research

Thyroid Cancer in Patients with Toxic Nodular Goiter, Is the Incidence Increasing?
The purpose of this study was to determine if there has been an increase in the incidence of thyroid cancer in patients operated on for TNG. Patients who underwent thyroidectomy for TNG were identified from a prospectively-maintained thyroid database and rates of malignancy were compared during the intervals from 1990-1999, 2000-2009 and 2010-2014. Overall, seven (4.7%) of 148 patients were found to have thyroid cancer, one (3.2%) of 31 from 1990-1999, three (4.2%) of 72 from 2000-2009, and three (6.7%) of 45 from 2010-2014. As there was no significant increase in the rate of incidental carcinoma in TNG between the three t...
Source: American Journal of Surgery - March 26, 2015 Category: Surgery Authors: Kevin C. Choong, Christopher R. McHenry Source Type: research

Characteristics of thyroid nodules causing globus symptoms
In conclusion, thyroid nodules with specific size and location can cause globus symptoms, and this finding can be indicated in patient counseling. Also, conservative treatments or thyroidectomy may be helpful in relieving patients’ globus symptoms. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - March 25, 2015 Category: ENT & OMF Source Type: research

Pediatric papillary thyroid cancer >1 cm: is total thyroidectomy necessary?
This study examined the association between operation type and overall survival (OS) for tumors >1cm in size in the pediatric population. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - March 25, 2015 Category: Surgery Authors: Tate Nice, Sebastian Pasara, Melanie Goldfarb, John Doski, Adam Goldin, Kenneth W. Gow, Jed G. Nuchtern, Sanjeev A. Vasudevan, Monica Langer, Elizabeth A. Beierle Source Type: research

Follicular thyroid carcinoma with skull metastases.
We present the cases of a 70-year-old female and a 74-year-old female who presented with painless, large slow-growing masses of the skull. The patients underwent surgical excision of the skull masses, which were histologically diagnosed as metastatic follicular thyroid cancer, and total thyroidectomy, which confirmed the diagnosis of follicular thyroid carcinoma. They were treated with radioiodine and suppressive levothyroxine, which achieved local control of the disease. Management of metastatic thyroid cancer, requires a multidisciplinary approach and multimodality treatment. Distant metastases should be surgically remov...
Source: Endocrine Journal - March 24, 2015 Category: Endocrinology Tags: Endocr J Source Type: research

The Impact of Thyroidectomy on Vocal Quality Characteristics
With no laryngeal nerve injury, do vocal characteristics change after thyroidectomy? Background: Vocal dysfunction is a feared complication of thyroidectomy. While operative injury to the recurrent laryngeal nerve is a primary cause of voice alterations, changes have also been noted in the absence of this injury. Study design: Prospective study of patients one week prior […] (Source: ENTtoday - TRIO Best Practices)
Source: ENTtoday - TRIO Best Practices - March 24, 2015 Category: ENT & OMF Authors: Sue Pondrom Tags: Laryngology Literature Reviews Practice Focus laryngeal nerve injury thyroidectomy vocal Source Type: research

Minimally invasive video-assisted thyroidectomy: Ascending the learning curve
Conclusions: Advances in skills and technology allow surgeons to easily reproduce the standard open total thyroidectomy with video-assistance. Although the learning curve represents a time-consuming step, training remains a crucial point in gaining a reasonable confidence with video-assisted surgical technique. (Source: Journal of Minimal Access Surgery)
Source: Journal of Minimal Access Surgery - March 24, 2015 Category: Surgery Authors: Michela Giulii CapponiCarlo BellottiMarco LottiLuca Ansaloni Source Type: research

Thyroid metastasis as initial presentation of clear cell renal carcinoma
Conclusion the possibility of finding of an incidental metastatic tumor in the thyroid gland from a previous unknown and non-diganosed primary (as CCRC in our case was) is rare and account only for less than 1% of malignancies. Nonetheless, the thyroid gland is a frequent site of metastasis and the presence of “de novo” thyroid nodules in oncologic patients must be always considered and studied. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - March 24, 2015 Category: Surgery Source Type: research

Thyroid eye disease: a Southeast Asian experience
Conclusions Corneal erosion secondary to acquired epiblepharon is a common sign in East Asian patients with TED, thus increased awareness among physicians should be encouraged. Mean exophthalmometry values and frequencies of upper eyelid retraction and oedema are lower in East Asian patients compared with Caucasian patients. Among Singapore's multi-ethnic population, Malay patients with TED had the highest exophthalmometry reading. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - March 23, 2015 Category: Opthalmology Authors: Lim, N. C. S., Sundar, G., Amrith, S., Lee, K. O. Tags: Muscles, Optic nerve, Orbit, Neurology Original articles - Clinical science Source Type: research

Detection of BRAF Mutations on Direct Smears of Thyroid Fine-Needle Aspirates Through Cell Transfer Technique.
CONCLUSIONS: PCR-based BRAF mutational testing can be reliably performed on the direct smears of the thyroid FNA specimens through the application of CTT. PMID: 25780001 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 21, 2015 Category: Pathology Authors: Shi Q, Ibrahim A, Herbert K, Carvin M, Randolph M, Post KM, Curless K, Chen S, Cramer HM, Cheng L, Wu HH Tags: Am J Clin Pathol Source Type: research

Single-center study of familial papillary thyroid cancer in China: surgical considerations
In this study, we investigated familial occurrence of PTC in China and reviewed our experience of its surgical treatment. Methods: The clinical records of 248 consecutive patients with an established diagnosis of PTC who were admitted to Nanfang Hospital for thyroidectomy between January 2011 and June 2013 were analyzed in this study. Patients included 66 males and 182 females, aged 11 to 76 years. Results: Twenty-two patients (8.9%) with a positive family history were confirmed. Patients with FPTC had a predilection for female subjects and tended to be younger than other patients, but the difference was not significant (...
Source: World Journal of Surgical Oncology - March 21, 2015 Category: Cancer & Oncology Authors: Shangtong LeiDa WangJunna GeHao LiuDonghui ZhaoGuoxin LiZihai Ding Source Type: research

Comparison of F-18 FDG-PET/CT and Tc-99m MIBI in the preoperative evaluation of cold thyroid nodules in the same patient group
Abstract Recent studies have reported that standardized uptake values of FDG-PET imaging might predict malignant thyroid nodules and can be used in the preoperative evaluation of thyroid lesions. The aim of our study was to evaluate FDG-PET imaging in patients with cold thyroid nodules and to compare the imaging findings with Tc-99m MIBI scans and with post-op histopathology results. Twenty-three patients (18F, 5M) with 24 nodules that were suspicious in ultrasound and cold in Tc-99m pertechnetate scan, were included in the study. Each nodule underwent sonographically guided fine-needle aspiration biopsy. FDG-...
Source: Endocrine - March 21, 2015 Category: Endocrinology Source Type: research

Thyroidectomy in the Professional Singer-Neural Monitored Surgical Outcomes.
Conclusion Neural monitored thyroidectomy, including for thyroid malignancy, in professional voice users is safe without any changes in three different voice/ singing instruments, with 100 % return to performance. Intraoperative EMG data at the conclusion of surgery and postoperative laryngeal exam were normal in all patients. Specific vocal parameters are transiently affected during the postoperative recovery phase, which is important to outline in the consent process of this unique patient population and may provide insight into the physiologic state of the larynx subsequent to thyroid surgery. PMID: 25790153 [PubMed...
Source: Thyroid : official journal of the American Thyroid Association - March 20, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

A Phase II Trial of Bexarotene for Advanced Differentiated Thyroid Cancer.
CONCLUSIONS: Only a minority of thyroid cancer patients were able to stay on bexarotene for up to a year due to either disease progression or drug toxicity. Additionally, there was no signal for improved radioiodine concentration with bexarotene in advanced differentiated thyroid cancer. In the era of reasonably tolerated TKI therapy, bexarotene does not appear to be a useful therapeutic option. If further studies are considered, they should focus on patients with RXRγ+positive tumors. PMID: 25778496 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 20, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

The “Siamese twins” polyps
A 79 year-old patient underwent colonoscopy for moderate sideropenic anaemia. During examination, a 3cm pedunculated polyp with hyperaemic and eroded surface and a long stalk was seen in the sigmoid colon (Fig. 1). Polypectomy was performed a few days later as an inpatient procedure, as the patient had multiple comorbidities (heart disease, pacemaker, hypertension, previous thyroidectomy and gastric resection for peptic ulcer). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 19, 2015 Category: Gastroenterology Authors: Marco Bianchi, Valeria Clemente, Maurizio Koch Tags: Image of the Month Source Type: research

Value of sentinel lymph node biopsy in papillary thyroid cancer: initial results of a prospective trial
The objectives of the study were to evaluate the performance of sentinel lymph node biopsy (SLNB) in detecting occult metastases in papillary thyroid carcinoma (PTC) and to correlate their presence to tumor and patient characteristics. Twenty-three clinically node-negative PTC patients (21 females, mean age 48.4 years) were prospectively enrolled. Patients were submitted to sentinel lymph node (SLN) lymphoscintigraphy prior to total thyroidectomy. Ultrasound-guided peritumoral injections of 99mTc-phytate (7.4 MBq) were performed. Cervical single-photon emission computed tomography and computed tomography (SPECT/CT) image...
Source: European Archives of Oto-Rhino-Laryngology - March 19, 2015 Category: ENT & OMF Source Type: research

Post-operative stimulated thyroglobulin and neck ultrasound as personalized criteria for risk stratification and radioactive iodine selection in low- and intermediate-risk papillary thyroid cancer
Abstract The purpose of this study was to demonstrate the utility of a personalized risk stratification and radioactive iodine (RAI) selection protocol (PRSP) using post-operative stimulated thyroglobulin (Stim-Tg) and neck ultrasound in low- and intermediate-risk papillary thyroid carcinoma (PTC) patients. Patients with PTC tumors ≥1 cm were prospectively followed after total thyroidectomy and selective therapeutic central compartment neck dissection. Low/intermediate risk was defined as PTC confined to the thyroid or central (level VI) lymph nodes. Stim-Tg and neck ultrasound were performed approximately 3 ...
Source: Endocrine - March 19, 2015 Category: Endocrinology Source Type: research

Stressing the recurrent laryngeal nerve during thyroidectomy
ConclusionThe stiffer left RLN and the higher tension generated in the right RLN during thyroidectomy may jointly contribute to the higher right RLN palsy rate. (Source: ANZ Journal of Surgery)
Source: ANZ Journal of Surgery - March 19, 2015 Category: Surgery Authors: Jonathan W. Serpell, James C. Lee, Wing K. Chiu, Glenn Edwards Tags: Original Article Source Type: research

Anaesthetic management for laparoscopic bilateral adrenalectomy in MEN2A (Multiple endocrine neoplasia) followed by subsequent total thyroidectomy and radical neck dissection
(Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - March 18, 2015 Category: Anesthesiology Authors: Foo, C. W., Chen, X. Y., Kumar, C. M. Tags: Correspondence Source Type: research

Quantitative reverse transcription polymerase chain reaction based detection of thyroid‐specific gene expression in fine‐needle aspirate for thyroid cancer recurrence evaluation: A case report and review of the literature
Conclusions: This case demonstrates a novel approach used in the evaluation for recurrent thyroid cancer as an adjunct to FNA cytology. This article is protected by copyright. All rights reserved. (Source: Head and Neck)
Source: Head and Neck - March 17, 2015 Category: ENT & OMF Authors: Saïd C. Azoury, Rachel Aufforth, Mei He, Zhiming Yang, Naris Nilubol, Electron Kebebew Tags: Case Report Source Type: research

Serum thyroglobulin measured with a second-generation assay in patients undergoing total thyroidectomy without radioiodine remnant ablation: A prospective study.
CONCLUSIONS: An important decline in serum Tg occurred between 3 and 6 months after total thyroidectomy. One year after surgery, Tg was undetectable in approximately 60% of the patients and ≤ 2 ng/ml in all of them. PMID: 25763842 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 15, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

The utility of frozen section examination for determining the extent of thyroidectomy in patients with a thyroid nodule and “atypia/follicular lesion of undetermined significance”
Conclusion Ultrasound in combination with FSE is of value for determining the extent of thyroidectomy in patients with AFLUS. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - March 14, 2015 Category: Surgery Source Type: research

Aesthetic comparison between synthetic glue and subcuticular sutures in thyroid and parathyroid surgery: a single-blinded randomised clinical trial.
In conclusion, synthetic glue differs from subcuticular suture in post-thyroidectomy or post-parathyroidectomy incision for early aesthetic results, with better outcomes for subcuticular sutures. At 3 months, there were no differences in aesthetic outcomes between groups. Moreover, sex, incision length, age, cold/hot blade and correspondence of the incision with a wrinkle in the skin did not seem to influence aesthetic outcomes with this type of incision. PMID: 25762833 [PubMed - as supplied by publisher] (Source: Acta Otorhinolaryngologica Italica)
Source: Acta Otorhinolaryngologica Italica - March 13, 2015 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research

Thyroid Fine-needle aspiration biopsy: an evaluation of its utility in a community setting
Background: Thyroid cancer rates are on the rise worldwide with over 5000 new cases estimated in Canada in 2012. The American Thyroid Association recommends the use of fine-needle aspiration biopsy (FNA) in the workup of thyroid nodules. Studies show that thyroid FNA accuracy may vary based on interpretation by cytopathologists in academic versus community centres. To date, there has been no literature published addressing the accuracy or utility of preoperative FNA in a Canadian community center. Our goals were to demonstrate the accuracy of thyroid FNA at our centre, and to compare our results to those published in the l...
Source: Journal of Otolaryngology - Head and Neck Surgery - March 12, 2015 Category: ENT & OMF Authors: Andre LeGreg ThompsonBenjamin Hoyt Source Type: research

Initial Treatment Patterns in Younger Adult Patients with Differentiated Thyroid Cancer in California.
Conclusions: Younger patients with DTC in California are more likely to be female and Hispanic with papillary histology. After adjustment for disease and demographic characteristics, younger patients are more likely to undergo total thyroidectomy as their initial surgery and are more likely to receive radioiodine. Given their excellent prognosis and the potential for adverse sequelae from initial treatment for DTC, these findings warrant consideration when managing younger patients with DTC. PMID: 25744759 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 7, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

A correlation between decreased parathyroid α-Klotho and fibroblast growth factor receptor 1 expression with pathological category and parathyroid gland volume in dialysis patients
Conclusion The expression of α-Klotho and FGFR1 decreases in the parathyroid glands of dialysis patients with secondary hyperparathyroidism, and this decrease may play an important role in the pathogenesis of secondary renal hyperparathyroidism. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 6, 2015 Category: Urology & Nephrology Source Type: research

Immunohistochemical‐ and PCR‐based assay for the reproducible, routine detection of erythrovirus B19 in thyroid tissues
In conclusion, EVB19 can be detected in thyroid follicle cells by using immunohistochemical and qPCR assays. Ideally, patients should be tested with both PCR and immunohistochemical assays, in order to unequivocally confirm or rule out the presence of EVB19 in the thyroid gland. The present protocol must now be validated in larger series — notably with respect to its reliability and in order to determine qPCR positivity thresholds for application in future large‐scale studies. J. Med. Virol. 00: 1–6, 2015. © 2015 Wiley Periodicals, Inc. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - March 6, 2015 Category: Virology Authors: Cyril Page, Thomas W. Hoffmann, Nazim Benzerdjeb, Rachel Desailloud, Henri Sevestre, Gilles Duverlie Tags: Research Article Source Type: research

Harmonic focus in thyroidectomy for substernal goiter
The objective of this study was to evaluate the use of harmonic scalpel (FOCUS shear, Ethicon Endo-Surgery) in thyroidectomy for substernal goiter for blood loss, operative time, hospital stay and complications. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - March 6, 2015 Category: ENT & OMF Authors: Christoffer Holst Hahn, Waldemar Trolle, Christian Hjort Sørensen Source Type: research

Factors Affecting the Locoregional Recurrence of Conventional Papillary Thyroid Carcinoma After Surgery: A Retrospective Analysis of 3381 Patients.
CONCLUSIONS: Tumor size, bilaterality, gross ETE, lymph node metastasis, and vascular invasion were associated with locoregional recurrence. Evaluation of these prognostic factors appears to help identify patients who require close monitoring. PMID: 25743326 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - March 6, 2015 Category: Cancer & Oncology Authors: Suh YJ, Kwon H, Kim SJ, Choi JY, Lee KE, Park YJ, Park DJ, Youn YK Tags: Ann Surg Oncol Source Type: research

Predictive Factors for Occult Contralateral Carcinoma in Patients with Unilateral Papillary Thyroid Microcarcinoma by Preoperative Ultrasonographic and Pathological Features
Conclusion We demonstrated that an absence of a well-defined margin and the presence of a probably benign nodule in the contralateral lobe were independent predictive factors for contralateral occult carcinoma in patients with unilateral PTMC in preoperative US. The prediction of contralateral occult carcinoma in unilateral PTMC using preoperative US features could be useful for determining the optical extent of surgery. (Source: World Journal of Surgery)
Source: World Journal of Surgery - March 5, 2015 Category: Surgery Source Type: research

Total thyroid ablation in Graves’ orbitopathy
Abstract Graves’ orbitopathy (GO) is an autoimmune condition almost always associated with autoimmune thyroid disease, especially Graves’ disease (GD). According to the most widely accepted model, the autoantigens responsible for GO would include molecules expressed by thyroid epithelial cells that are present also in orbital tissues. The high likelihood that the etiologies of GO and of the underlying autoimmune thyroid diseases are somehow linked is confirmed by the very close relationship between GO, the onset and the course of Graves’ diseases, the size of the thyroid gland, and most importantly, thyroid ...
Source: Journal of Endocrinological Investigation - March 5, 2015 Category: Endocrinology Source Type: research

Thyroidectomy Using Pure Natural Orifice Transluminal Endoscopic Surgery in a Porcine Model
This study aimed to develop an incision‐free surgical procedure for thyroid lobectomy using pure NOTES with an oral approach. In six pig carcasses, an incision was made between the mandible and subcutaneous tissue under direct vision. After subcutaneous dissection and identification of the hyoid bone, the operative field was developed under endoscopic view. After the thyrohyoid membrane was identified, dissection was continued along the thyroid cartilage until the cricoid cartilage was identified and the thyroid isthmus was reached. An original retractor was inserted between dissected tissues to lift and fix the carcass....
Source: Artificial Organs - March 4, 2015 Category: Transplant Surgery Authors: Kanae Nitta, Norihiko Ishikawa, Masahiko Kawaguchi, Akishi Ooi, Go Watanabe Tags: Main Text Article Source Type: research

Does Postthyroidectomy Syndrome Really Exist Following Thyroidectomy? Prospective Comparative Analysis of Open vs. Endoscopic Thyroidectomy.
CONCLUSION: PTS really exists following simple thyroidectomy and are very common for both OPEN and ENDO groups. Most of the parameters improved gradually over time, but some subjective changes persisted 6 months postoperatively. PMID: 25729500 [PubMed] (Source: Clinical and Experimental Otorhinolaryngology)
Source: Clinical and Experimental Otorhinolaryngology - March 3, 2015 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Total Endoscopic Versus Conventional Open Thyroidectomy for Papillary Thyroid Microcarcinoma
Conclusions: Total endoscopic thyroidectomy appears to be a much feasible safe surgical procedure for papillary thyroid microcarcinoma in selected patients. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - March 1, 2015 Category: Surgery Tags: Clinical Studies Source Type: research

Post-thyroidectomy chronic asthenia: self-deception or disease?
Abstract There is clinical evidence that post-total thyroidectomy (TT) patients can present persistent asthenia. The aim of this study was to evaluate the prevalence of asthenia symptoms in such patients, assess whether a chronic asthenia syndrome could be caused by TT or become evident after it. An observational study was carried out comparing two groups of 100 patients each, all with homogeneous characteristics. Group A was treated with total lobectomy (TL), Group B with TT. All patients presented normal thyroid hormone levels. The patients were interviewed in order to identify the ones affected by post-operati...
Source: Endocrine - March 1, 2015 Category: Endocrinology Source Type: research

Previous gastric bypass surgery complicating total thyroidectomy.
We present the case of a 58-year-old woman who underwent a total thyroidectomy for the follicular variant of papillary thyroid carcinoma. Her history included Roux-en-Y gastric bypass surgery. Following the thyroid surgery, she developed postoperative hypocalcemia that required large doses of oral calcium carbonate (7.5 g/day), oral calcitriol (up to 4 μg/day), intravenous calcium gluconate (2.0 g/day), calcium citrate (2.0 g/day), and ergocalciferol (50,000 IU/day). Her serum calcium levels remained normal on this regimen after hospital discharge despite persistent hypoparathyroidism. Bariatric surgery patients who under...
Source: Ear, Nose and Throat Journal - March 1, 2015 Category: ENT & OMF Authors: Alfonso B, Jacobson AS, Alon EE, Via MA Tags: Ear Nose Throat J Source Type: research

Protracted hypocalcemia following post-thyroidectomy lumbar rhabdomyolysis secondary to evolving hypoparathyroidism.
Abstract Rhabdomyolysis is characterized by skeletal muscle breakdown. It is a potential cause of serious electrolyte and metabolic disturbances, acute kidney insufficiency, and death. Recently, rhabdomyolysis has been increasingly recognized following certain surgical procedures. We discuss the case of a morbidly obese 51-year-old woman who developed postoperative rhabdomyolysis of the lumbar muscles following a prolonged thyroidectomy for a large goiter. We discuss how her morbid obesity, the supine surgical position, the duration of surgery (including prolonged exposure to anesthetic agents), and postoperative i...
Source: Ear, Nose and Throat Journal - March 1, 2015 Category: ENT & OMF Authors: Cheema UY, Vogler CN, Thompson J, Sattovia SL, Vallurupalli S Tags: Ear Nose Throat J Source Type: research

Usefulness of 131 I-SPECT/CT and 18 F-FDG PET/CT in Evaluating Successful 131 I and Retinoic Acid Combined Therapy in a Patient with Metastatic Struma Ovarii
Abstract Metastatic struma ovarii is an extremely rare disease, and the treatment of choice has not been established. Here, we introduce the case of a 36-year-old female pregnant patient with metastatic struma ovarii. Initial treatment was an exploratory laparotomy to remove multiple peritoneal masses. After delivery, a total thyroidectomy was done for the further 131I-therapy. 131I-SPECT/CT and 18 F-FDG PET/CT showed multiple hepatic metastases and extensive peritoneal seeding nodules. Multiple 131I and retinoic acid combination therapies were performed, resulting in marked improvement. 131I-SPECT/CT and 18 ...
Source: Nuclear Medicine and Molecular Imaging - March 1, 2015 Category: Nuclear Medicine Source Type: research

Disseminated bone metastases from occult thyroid cancer effectively treated with debulking surgery and a single dosimetry-guided administration of radioiodine
Publication date: March–April 2015 Source:Revista Española de Medicina Nuclear e Imagen Molecular (English Edition), Volume 34, Issue 2 Author(s): Elisa Borsò , Giuseppe Boni , Sara Mazzarri , Arturo Cocciaro , Carlo Gambacciani , Antonio C. Traino , Giampiero Manca , Mariano Grosso , Cristian Scatena , Valerio Ortenzi , Riccardo Vannozzi , Maria Cristina Marzola , Domenico Rubello , Giuliano Mariani In this paper we report on a successful management of multiple bone metastases from differentiated thyroid cancer. In 2007, a 75-year-old female patient, previously referred for thyroidectomy for multinodular goiter, und...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - February 28, 2015 Category: Nuclear Medicine Source Type: research

Impact of tumor size on subclinical central lymph node metastasis in papillary thyroid microcarcinoma depends on age
Conclusions: Factors predictive of central LNM in patients with PTMC differed by age. PTMC size was an independent predictor of subclinical central LNM only in patients aged ≥45 years. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - February 28, 2015 Category: Cancer & Oncology Authors: Ju-Yeon KimEun JungTaejin ParkSang-Ho JeongChi-Young JeongYoung-Tae JuYoung-Joon LeeSoon-Chan HongSang-Kyung ChoiWoo-Song Ha Source Type: research

Improving the functionality of intra-operative nerve monitoring during thyroid surgery: is lidocaine an option?
Abstract Intra-operative nerve monitoring (IONM) is rapidly becoming a standard of care in many institutions across the country. In the absence of neuromuscular blocking agents to facilitate the IONM, the depth of anesthesia required to abolish the laryngo tracheal reflexes often results in profound hemodynamic instability during surgery, necessitating the use of large doses of sympathomimetic amines. The excessive alpha and beta adrenergic effects exhibited by these agents are undesirable in the presence of cardiovascular co-morbidities. Trying to strike a balance frequently results in an unsatisfactory intra-oper...
Source: Clin Med Res - February 27, 2015 Category: Research Authors: Govindarajan R, Shah A, Reddy VS, Parithivel V, Ravikumar S, Livingstone D Tags: J Clin Med Res Source Type: research