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Additional Lateral Neck Dissection Unnecessary for Papillary Thyroid Carcinoma Patients with Lateral Neck Lymph Node Metastases but Negative Intraoperative Frozen Section Findings
Conclusion Total thyroidectomy with subsequent LND is not necessary in PTC patients who are diagnosed with LNM according to their permanent pathology report but have negative intraoperative frozen section findings. Head Neck, 2014 (Source: Head and Neck)
Source: Head and Neck - October 17, 2014 Category: ENT & OMF Authors: Seok‐Mo Kim, Hyeung Kyoo Kim, Kuk‐Jin Kim, Ho Jin Chang, Bup‐Woo Kim, Yong Sang Lee, Hang‐Seok Chang, Cheong Soo Park Tags: Original Article Source Type: research

The different requirement of l-T4 therapy in congenital athyreosis compared with adult-acquired hypothyroidism suggests a persisting thyroid hormone resistance at the hypothalamic-pituitary level.
CONCLUSIONS: To correct hypothyroidism, patients of group CH required a daily l-T4 dose/kg higher than group AH patients, despite higher levels of TSH. The different requirement of replacement therapy between adult patients with congenital and those with surgical athyroidism could be explained by a lack of thyroid hormones since fetal life in CH, which could determine a different set point of the hypothalamus-pituitary-thyroid axis. PMID: 25305309 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 16, 2014 Category: Endocrinology Authors: Bagattini B, Cosmo CD, Montanelli L, Piaggi P, Ciampi M, Agretti P, Marco GD, Vitti P, Tonacchera M Tags: Eur J Endocrinol Source Type: research

Prognostic significance of thyroglobulin antibody epitopes in differentiated thyroid cancer.
Conclusions: TgAb epitope restriction is associated with a less favourable prognosis than non-specific reactivity in DTC patients. TgAb epitope specificities may have prognostic value in DTC. PMID: 25322272 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 16, 2014 Category: Endocrinology Authors: Lupoli G, Okosieme O, Evans C, Clark P, Pickett A, Premawardhana L, Lupoli G, Lazarus J Tags: J Clin Endocrinol Metab Source Type: research

Does papillary thyroid carcinoma have a better prognosis with or without Hashimoto thyroiditis?
Conclusions Our results show that HT in patients with PTC is associated with a low probability of BRAF V600E mutations. Moreover, HT was correlated with some factors that were associated with less aggressive clinical features and inversely related to recurrence. Therefore, these results may be useful to predict whether PTC concurrent with HT exhibits a better prognosis than PTC alone. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 14, 2014 Category: Cancer & Oncology Source Type: research

Genetic disorders of pediatric MEN2A patients in the south of Spain
Conclusion The mutation found in the RET proto-oncogene responsible for MEN2A in pediatric patients in the south of Spain is the C635Y. It is considered a high-risk mutation, associated with an earlier malignant transformation and development of MTC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 11, 2014 Category: Cancer & Oncology Source Type: research

Rare complication after thyroidectomy-cervical esophageal stenosis: a case report and literature review
We report a case of esophageal stenosis following thyroidectomy performed at a peripheral hospital. The patient initially underwent a thyroidectomy for papillary thyroid carcinoma involving the cervical esophagus; esophageal perforation was noted intraoperatively, and closed using three number 4 silk sutures. Cervical esophageal stenosis subsequently developed after conservative care. The patient was successfully treated with cervical esophagectomy and reconstruction using a tubed forearm free flap after a failed attempt at endoscopic recanalization. This case is discussed in conjunction with a review of the literature. (S...
Source: World Journal of Surgical Oncology - October 11, 2014 Category: Cancer & Oncology Authors: Hanwei PengSteven WangWeixiong Li Source Type: research

Pheochromocytoma as the first manifestation of MEN2A with RET mutation S891A: report of a case
We report a rare case with pheochromocytoma as the first manifestation of multiple endocrine neoplasia type 2A with RET mutation S891A. Bilateral pheochromocytomas were identified in a 54-year-old woman. Screening for RET revealed a rare S891A mutation located in the intracellular tyrosine kinase domain. This mutation was previously recognized as one of the mutations only in cases manifesting solely medullary thyroid carcinomas (MTCs). Since calcitonin stimulation test indicated positive result, total thyroidectomy was performed 1 year after the bilateral adrenalectomy, and C-cell hyperplasia was diagnosed by histopatholo...
Source: Surgery Today - October 10, 2014 Category: Surgery Source Type: research

CA19-9-producing lung metastasis after surgery for papillary thyroid carcinoma: report of a case
Abstract Measuring tumor marker levels following cancer treatment can be useful. Although serum thyroglobulin is a useful marker after total thyroidectomy for papillary thyroid carcinoma (PTC), it is not a reliable marker for patients with a high titer of anti-thyroglobulin antibodies or when transformation to undifferentiated carcinoma has occurred. The female patient in this case report underwent total thyroidectomy and oral I-131 therapy for PTC at the age of 47 years, followed by cervical lymph node and lung resections for metastases, 3 and 11 years later, respectively. She also received oral I-131 therapy ...
Source: Surgery Today - October 10, 2014 Category: Surgery Source Type: research

From Hypocalcemia to Hypercalcemia - An Unusual Clinical Presentation of a Patient with Permanent Post-Surgical Hypoparathyroidism.
Conclusion: Clinicians should have a high index of suspicion for malignancy when patients presents with rapid and high elevations of serum calcium. PMID: 25303492 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 10, 2014 Category: Endocrinology Authors: Sundaresh V, Levine SN Tags: J Clin Endocrinol Metab Source Type: research

Robotic Thyroidectomy for Cancer in the US: Patterns of Use and Short-Term Outcomes
Conclusions Use of robotic thyroidectomy for thyroid cancer is limited to a few institutions, with short-term outcomes that are comparable to open surgery. Multi-institutional studies should be undertaken to compare thyroidectomy-specific complications and long-term outcomes. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - October 8, 2014 Category: Cancer & Oncology Source Type: research

Spindle Cell Sarcoma of Thyroid: A Case Report
We report a case of 60 year old man who presented with 2 months history of rapidly growing thyroid enlargement with no obstructive features and preliminary diagnosis of spindle cell lesion of thyroid was made with cytological examination. He underwent total thyroidectomy and histological examination revealed spindle cell sarcoma of thyroid confirmed by immunohistochemical reactions. He was subjected to adjuvant chemoradiotherapy and is on follow up. Sarcoma of thyroid is rarely encountered in routine practice and is diagnosed by microscopic evaluation and immunohistochemical staining which determines the cellular origin ...
Source: Indian Journal of Surgical Oncology - October 8, 2014 Category: Cancer & Oncology Source Type: research

Does perioperative dexamethasone affect voice-related quality of life after thyroidectomy?
This study is a retrospective review of prospectively collected data in a tertiary referral center. This is a retrospective analysis of prospectively collected data on adult patients undergoing total thyroidectomy. Exclusion criteria were: previous neck surgery, thyroid lobectomy, neck dissection or other procedure together with thyroidectomy, pathological findings on laryngeal examination, preoperative or postoperative steroid therapy, diabetes mellitus, pregnancy, and postoperative recurrent laryngeal nerve palsy. In all patients, flexible laryngoscopy was performed and Voice Handicap Index (VHI) scores were obtained the...
Source: European Archives of Oto-Rhino-Laryngology - October 6, 2014 Category: ENT & OMF Source Type: research

Unexpectedly Expected Fetal Thyroid Function on Posttreated Radioiodine (131I) SPECT/CT of a Patient With Differentiated Thyroid Cancer
We present a 25-year-old woman who has a diagnosis of differentiated thyroid cancer, a 2.5-cm papillary carcinoma in the right lobe, and presence of minimal extrathyroid invasion. 131I ablation and/or treatment of 150 mCi was given orally 3 months after total thyroidectomy. A fetus with radioiodine uptake in the fetal thyroid was unsuspectedly detected by SPECT/CT after 131I treatment. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - October 4, 2014 Category: Radiology Tags: Interesting Images Source Type: research

131I Uptake in Intraosseous Hemangioma of the Skull: Mimicking a Bone Metastasis in Thyroid Cancer
We report a case of unusual 131I uptake in the skull in a patient who received total thyroidectomy and cervical lymph node dissection for papillary thyroid carcinoma. This uptake mimicked a bone metastasis on posttherapeutic 131I whole-body scan. The lesion was further evaluated by 131I SPECT/CT and MRI, and it was identified as intraosseous hemangioma. For the prevention of unnecessary repeat ablation therapies and physicians’ confusion, the nuclear medicine physicians have to consider the 131I accumulation in the skull intraosseous hemangioma as a possible cause of false-positive uptake. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - October 4, 2014 Category: Radiology Tags: Interesting Images Source Type: research

Superiority of delayed risk stratification in differentiated thyroid cancer after total thyroidectomy and radioactive iodine ablation
Aim: The aim of this study was to validate the effectiveness of delayed risk stratification (DRS) in predicting structural progression and compare the predictive value of American Thyroid Association (ATA) risk stratification with that of DRS in patients with differentiated thyroid cancer (DTC). Methods: A total of 398 patients with DTC who underwent surgery followed by radioactive iodine ablation were enrolled. Patients were categorized as having excellent response, acceptable response, biochemical incomplete response, or structural incomplete response at 8–15 months’ evaluation after radioactive iodine ablation for D...
Source: Nuclear Medicine Communications - October 3, 2014 Category: Radiology Tags: Original Articles Source Type: research

Emptying effect of massage on parotid gland radioiodine content
Background: To prevent salivary dysfunction in thyroid cancer patients who have undergone radioiodine ablation, massaging the parotid gland (PG) is presumed to be helpful for the removal of radioiodine. The purpose of this study was to evaluate the effect of PG massage in the removal of radioiodine from the PG. Methods: Forty-four patients (female, 38; 49.1±11.0 years) who underwent total thyroidectomy followed by I-131 ablation were included in this prospective study. Three serial salivary gland scans were performed 2 h after administration of I-123 in thyroid hormone withdrawal status. The patients were divided into t...
Source: Nuclear Medicine Communications - October 3, 2014 Category: Radiology Tags: Original Articles Source Type: research

A comprehensive score to diagnose Hashimoto’s thyroiditis: a proposal
Abstract The heterogeneity of diagnostic criteria of Hashimoto’s thyroiditis leads to overdiagnosis and prevents strong conclusions from being drawn in clinical studies. The aim of this study is to propose a comprehensive scoring system. A case–control study compared a set of presurgical features of patients with lymphocytic infiltration of the thyroid (Hashimoto’s thyroiditis) and controls, in order to design a multi-criteria scoring system. Given a dichotomous outcome (lymphocytic infiltration of the thyroid), a set of covariates was analyzed in 180 patients after total thyroidectomy. A different validatio...
Source: Endocrine - October 3, 2014 Category: Endocrinology Source Type: research

Diagnostic performance of elastography in cytologically indeterminate thyroid nodules
The objective of our study was to evaluate the role of real-time elastography (RTE) for refining diagnosis of Thy3 nodules, by integrating diagnostic information provided by traditional ultrasound (US). The study included 108 patients with Thy3 nodules awaiting for surgery, which were evaluated by US (considering hypoecogenicity, irregular margins, microcalcifications, halo sign, and intranodular vascularization) and RTE. Nodules were classified at RTE using a four-class color scale. At histologic examination, 75 nodules were benign and 33 malignant. As expected, none of the ultrasound parameters alone was adequate in pred...
Source: Endocrine - October 2, 2014 Category: Endocrinology Source Type: research

False-Positive Uptake of 124I in a Laryngeal Cyst Mimicking Thyroid Remnant After Thyroidectomy and 131I Therapy for Follicular Thyroid Carcinoma
AbstractA 46-year-old woman underwent total thyroidectomy followed by 131I therapy for follicular thyroid carcinoma stage T3 N0 M0. Eleven years after diagnosis, the patient complained about voice changes and feared recurrent disease. Follow-up 124I PET/CT scan revealed focal uptake in the neck, in the absence of any anatomic substrate on CT. Physical examination including laryngoscopy did not show any tumor or signs of recurrent disease. MRI of the neck demonstrated an oval-shaped lesion in the right false vocal cord. The lesion was removed in toto using carbon dioxide laser. Histological examination demonstrated a benign...
Source: Clinical Nuclear Medicine - October 1, 2014 Category: Radiology Tags: Interesting Images Source Type: research

Benign intranodal thyroid tissue mimicking nodal metastasis in a patient with papillary thyroid carcinoma: A case report
Conclusion: This case illustrates that benign intranodal thyroid tissue may mimic nodal metastasis on US or CT in a patient with papillary thyroid carcinoma. Head Neck, 2014 (Source: Head and Neck)
Source: Head and Neck - October 1, 2014 Category: ENT & OMF Authors: Yoo Jin Lee, Dong Wook Kim, Ha Kyoung Park, Tae Kwun Ha, Do Hun Kim, Soo Jin Jung, Sang Kyun Bae Tags: Case Report Source Type: research

[Total thyroidectomy with lymph node dissection of the central compartment for node-positive, capsular invasive papillary thyroid cancer : Video contribution].
Abstract The aim of radical oncological surgery for nodal metastasized papillary thyroid cancer is, as for other oncological interventions in visceral surgery, the anatomy-related implementation of the concept of en bloc (no touch) resection of the organ bearing the primary tumor together with the first lymph node station, while the structures of the aerodigestive tract, the recurrent laryngeal nerves and parathyroid glands are preserved. The surgical technique is demonstrated in detail with the help of a video of the operation and which is available on-line, the advantages and disadvantages of the technique are di...
Source: Der Chirurg - October 1, 2014 Category: Surgery Authors: Dralle H, Nguyen Thanh P Tags: Chirurg Source Type: research

Extent of Surgery for Papillary Thyroid Cancer Is Not Associated With Survival: An Analysis of 61,775 Patients
Conclusions: Current guidelines suggest total thyroidectomy for PTC tumors >1 cm. However, we did not observe a survival advantage associated with total thyroidectomy compared with lobectomy. These findings call into question whether tumor size should be an absolute indication for total thyroidectomy. (Source: Annals of Surgery)
Source: Annals of Surgery - September 30, 2014 Category: Surgery Tags: Papers of the 134th ASA Annual Meeting Source Type: research

Preoperative dexmedetomidine attenuates hemodynamic responses to hydrodissection in patients undergoing robotic thyroidectomy
Conclusions A single preoperative dexmedetomidine injection attenuated hydrodissection-induced hemodynamic responses in patients undergoing robotic thyroidectomy. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 27, 2014 Category: Anesthesiology Source Type: research

A single surgeon's experience and surgical outcomes of 300 robotic thyroid surgeries using a bilateral axillo‐breast approach
ConclusionRobotic thyroidectomy using BABA is an effective and comparable treatment option. J. Surg. Oncol. © 2014 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - September 27, 2014 Category: Cancer & Oncology Authors: Wan Wook Kim, Jin Hyang Jung, Ho Yong Park Tags: Research Article Source Type: research

Hypopharyngeal fistula complicating difficult thyroidectomy for invasive papillary cancer.
In this report, we describe the clinical course of a patient with an invasive papillary thyroid carcinoma who underwent total thyroidectomy and developed hypopharyngeal fistula in the immediate postoperative period, a complication that has never been reported previously following thyroidectomy. Under conservative treatment, the fistula closed within two weeks and the patient was referred, in good condition, to the oncologist for completion of therapy. PMID: 25245720 [PubMed - in process] (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - September 26, 2014 Category: Surgery Authors: Rabie ME Tags: Ann R Coll Surg Engl Source Type: research

Current Status of Robotic Thyroid Surgery in South Korea: A Web-Based Survey
Conclusions Opinions differed regarding the advantages and disadvantages of two approaches for RoT. This may be due to differences in surgical procedure itself between two approach methods. Accumulation of RoT surgeon’s experiences might establish consensus regarding patient selection and indications for the RoT will need to be further investigated. (Source: World Journal of Surgery)
Source: World Journal of Surgery - September 25, 2014 Category: Surgery Source Type: research

Study: Widespread vitamin D deficiency in thyroidectomy patients
(Henry Ford Health System) A new study from researchers at Henry Ford Hospital in Detroit finds widespread vitamin D deficiency among patients who undergo a thyroidectomy, potentially putting them at greater risk for developing dangerously low blood calcium levels after surgery. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 25, 2014 Category: Global & Universal Source Type: news

Utility of BRAF mutation detection in fine‐needle aspiration biopsy samples read as “suspicious for papillary thyroid carcinoma”
ConclusionBRAF testing is a useful adjunct to improve PPV for patients with “suspicious for PTC” cytology. © 2014 Wiley Periodicals, Inc. Head Neck, 2014 (Source: Head and Neck)
Source: Head and Neck - September 25, 2014 Category: ENT & OMF Authors: Sebastian M. Jara, Ramneesh Bhatnagar, Hui Guan, Christopher D. Gocke, Syed Z. Ali, Ralph P. Tufano Tags: Original Article Source Type: research

Usefulness of 131I-SPECT/CT and 18F-FDG PET/CT in Evaluating Successful 131I and Retinoic Acid Combined Therapy in a Patient with Metastatic Struma Ovarii
Abstract Metastatic struma ovarii is an extremely rare disease, and the treatment of choice has not been established. Here, we introduce the case of a 36-year-old female pregnant patient with metastatic struma ovarii. Initial treatment was an exploratory laparotomy to remove multiple peritoneal masses. After delivery, a total thyroidectomy was done for the further 131I-therapy. 131I-SPECT/CT and 18 F-FDG PET/CT showed multiple hepatic metastases and extensive peritoneal seeding nodules. Multiple 131I and retinoic acid combination therapies were performed, resulting in marked improvement. 131I-SPECT/CT and 18 F...
Source: Nuclear Medicine and Molecular Imaging - September 25, 2014 Category: Radiology Source Type: research

Clinical, Pathologic, and Immunohistochemical Prognostic Factors in Dogs with Thyroid Carcinoma
Conclusions and Clinical ImportancePrognostic factors have been identified that provide relevant information for owners and clinicians. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - September 24, 2014 Category: Veterinary Research Authors: M. Campos, R. Ducatelle, G. Rutteman, H.S. Kooistra, L. Duchateau, H. Rooster, K. Peremans, S. Daminet Tags: Standard Article Source Type: research

1034p * total versus hemithyroidectomy for well differentiated thyroid cancer
Conclusions: Equivalent prognoses were observed for patients with tumors smaller than 5cm, cN0 and cM0 WDTC treated with lobectomy or total thyroidectomy. Adverse events were fewer in patients who underwent lobectomy than in those who underwent total thyroidectomy.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Kuba, S., Yamanouchi, K., Sakimura, C., Kawakami, F., Minami, S., Fujita, F., Takatsuki, M., Kobayashi, K., Kanetaka, K., Kuroki, T., Eguchi, S. Tags: head and neck cancer Source Type: research

1162p * serum thyroglobulin levels after reoperation for nodal recurrence in patients who underwent total thyroidectomy for papillary thyroid carcinoma (ptc)
Conclusions: A nodal recurrence after total thyroidectomy for PTC was not common during early follow-up period and detected mainly by ultrasonography. Even for the patients presenting nodal recurrence, a proper nodal dissection could reduce the Tg level.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Cho, D., Choi, K. H. Tags: neuroendocrine & amp; endocrine tumours and cup Source Type: research

Paediatric thyroid surgery is safe--experiences at a tertiary surgical centre.
CONCLUSION: This study demonstrated that paediatric thyroidectomy is safe as performed by this team of endocrine and paediatric surgeons, with acceptable morbidity even when total thyroidectomy was performed in the case of benign disease. PMID: 24573649 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 20, 2014 Category: Journals (General) Authors: Fahrner R, Ubersax L, Mettler A, Berger S, Seiler CA Tags: Swiss Med Wkly Source Type: research

JACS CME Featured Articles, Volume 219, October 2014
Examining national outcomes after thyroidectomy with nerve monitoring (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - September 20, 2014 Category: Surgery Tags: Continuing medical education program Source Type: research

Medullary thyroid carcinoma in children.
Abstract Medullary thyroid carcinoma (MTC) originates from thyroid parafollicular C cells, and it accounts for 5% of thyroid malignancies. MTC is sporadic in approximately 80% and hereditary in 20% of cases. When hereditary it can be associated with other benign endocrine neoplasias and/or typical nonendocrine diseases, thus configuring the multiple endocrine neoplasia syndromes (type 2, MEN2/familial MTC, FMTC). Sporadic MTC is usually diagnosed in adult life. Children with clinically evident MTC are belonging to MEN2 families, particularly MEN2A and MEN2B. Children belonging to families with FMTC are usually iden...
Source: Endocrine Development - September 20, 2014 Category: Endocrinology Authors: Viola D, Romei C, Elisei R Tags: Endocr Dev Source Type: research

Graves' disease in children.
Abstract Graves' disease is the most frequent cause of hyperthyroidism in children. It may occur at any time during childhood, but its frequency increases with age, peaking during adolescence. Antithyroid drugs (ATDs; methimazole or carbimazole) are usually recommended as the initial treatment and are generally well tolerated. The overall frequency of relapse is higher in children than in adults, with remission achieved in only 30% of children after a first course of treatment for about 2 years. More prolonged medical treatment may increase the remission rate to up to 50%. The identification of factors predictive o...
Source: Endocrine Development - September 20, 2014 Category: Endocrinology Authors: Léger J Tags: Endocr Dev Source Type: research

Airway management in a patient with severe tracheal stenosis: bilateral superficial cervical plexus block with dexmedetomidine sedation
Abstract A 54-year-old woman with a history of severe tracheal stenosis caused by papillary thyroid cancer with tracheal invasion was admitted for an elective surgery. A bilateral superficial cervical plexus block with 0.5 % ropivacaine 14 ml (7 ml per side) under dexmedetomidine sedation was performed, followed by tracheal dissection and endotracheal tube (ETT) insertion. The patient continued spontaneous respiration without any hypoxic event, and the bispectral index was maintained at a range of 50–80. After ETT insertion, a total thyroidectomy and tracheal resection with end-to-end anastomosis were perform...
Source: Journal of Anesthesia - September 20, 2014 Category: Anesthesiology Source Type: research

[Surgical assessment of complications after thyroid gland operations.]
CONCLUSION: Guidelines only define the treatment corridors of good clinical practice. Surgical expert reviews in malpractice suits concerning quality of care and causality between surgical management, complications and sequelae of complications are therefore highly dependent on the grounds and documentation of risk-oriented indications for thyroidectomy, intraoperative and postoperative surgical management. PMID: 25234502 [PubMed - as supplied by publisher] (Source: Der Chirurg)
Source: Der Chirurg - September 20, 2014 Category: Surgery Authors: Dralle H Tags: Chirurg Source Type: research

A systematic review and meta‐analysis evaluating completeness and outcomes of robotic thyroidectomy
ConclusionsRelative to OT, total thyroidectomy by RTAA was associated with fewer CLNs retrieved and less‐complete thyroid resection. However, using RTAA is unlikely to compromise the outcomes of low‐risk DTC because of its inherently good prognosis. Level of Evidence3a Laryngoscope, 2014 (Source: The Laryngoscope)
Source: The Laryngoscope - September 19, 2014 Category: ENT & OMF Authors: Brian Hung‐Hin Lang, Carlos K. H. Wong, Julian Shun Tsang, Kai Pun Wong, Koon Yat Wan Tags: Thyroid/Parathyroid Source Type: research

Learning curve for endoscope holder in endoscopic thyroidectomy via complete areola approach: a prospective study
Conclusion A specific learning curve for endoscope holder in ETCAA does exist. The initial 30 cases composed the infancy of the learning curve, and the endoscope holder could expect a learning curve of approximately 60 cases in order to achieve proficiency. Increasing the operating frequency would help shorten the learning curve. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - September 18, 2014 Category: Surgery Source Type: research

[Multiple endocrine neoplasia (MEN).]
Abstract CLINICAL ISSUE: Multiple endocrine neoplasia (MEN) types 1 and 2 are hereditary cancer syndromes. They are characterized by the occurrence of many benign and malignant tumor types. STANDARD TREATMENT: Carriers of a MEN1 or RET gene mutation can be identified before manifestation of the disease. Family screening allows the early diagnosis and therapy of gene carriers. TREATMENT INNOVATIONS: Early thyroidectomy in young patients with MEN2 results in a high cure rate of medullary thyroid carcinoma (MTC). Treatment with tyrosine kinase inhibitors (TKI), such as vadetanib and cabozantinib, represents an...
Source: Der Radiologe - September 17, 2014 Category: Radiology Authors: Raue F, Wilhelm T Tags: Radiologe Source Type: research

Tuesday Q and A: Several treatment options decrease symptoms of Graves’ disease
DEAR MAYO CLINIC: Three months ago I was diagnosed with Graves’ disease. I have decided to have a thyroidectomy and want to know what to expect after the procedure. Will all of my symptoms (Graves’ ophthalmopathy, heart palpitations, irritability) go away immediately after surgery? What are the side effects of having the thyroid removed? ANSWER: [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - September 16, 2014 Category: Databases & Libraries Source Type: news

Long-term efficacy of primary intraoperative recurrent laryngeal nerve reinnervation in the management of thyroidectomy-related unilateral vocal fold paralysis.
Conclusion: Primary intraoperative recurrent laryngeal nerve (RLN) reinnervation techniques demonstrated significant voice improvement at 24 months postoperatively and could be an effective alternative treatment for thyroidectomy-related permanent unilateral vocal fold paralysis (VFP). Objectives: To assess the long-term efficacy of intraoperative RLN reinnervation techniques in the management of thyroidectomy-related unilateral VFP. Methods: A prospective study was conducted from January 2008 to June 2012 at Soonchunhyang University Bucheon Hospital. Nineteen patients who underwent RLN reinnervation with either direct rei...
Source: Acta Oto-Laryngologica - September 16, 2014 Category: ENT & OMF Authors: Lee SW, Park KN, Oh SK, Jung CH, Mok JO, Kim CH Tags: Acta Otolaryngol Source Type: research

Ectopic thyroid tissue surrounding the right laryngeal nerve: a case report.
Abstract Ectopic thyroid tissue (ETT) is a rare developmental anomaly of the thyroid tissue which is defined as the presence of thyroid tissue in locations other than the pretracheal area. However, ectopic thyroid tissue in the lateral neck surrounding the recurrent laryngeal nerve is unusually found. Here we describe a case of a 64-year-old woman who was found bilateral thyroid goiter by the ultrasound examination. The total thyroidectomy plus a modified radical neck dissection was performed. Surprisingly we also found a nodule surrounding the right recurrent laryngeal nerve at the same time. Nevertheless the diag...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: He B, Li P, Yang K, Shan Y Tags: Int J Clin Exp Pathol Source Type: research

requires meticulous dissection and the technique has changed over time. We discuss the gold standard and evolving new methods of performing a thyroidectomy and the common complications and difficulties associated with these. Retrosternal goitres present slightly different challenges. The preoperative assessment and characterization of these retrosternal goitres and the associated increased complication rates are discussed. New techniques to minimize these complications such as nerve monitoring are now more routinely being utilized and are described in this article. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - September 15, 2014 Category: Surgery Authors: E.G. Kane, S. Shore Tags: Endocrine surgery Source Type: research

Erratum to: Low versus high radioiodine activity to ablate the thyroid after thyroidectomy for cancer: a meta-analysis of randomized controlled trials
(Source: Endocrine)
Source: Endocrine - September 12, 2014 Category: Endocrinology Source Type: research

Thyro-gastric autoimmunity in patients with differentiated thyroid cancer: a prospective study
Abstract Thyro-gastric autoimmunity has not been previously evaluated in patients with differentiated thyroid cancer (DTC), although its long-term complications may be relevant for the management of DTC patients. We assessed the prevalence of gastric autoimmunity and autoimmune gastritis (AG) in patients with Hashimoto’s thyroiditis (HT) and concomitant DTC. Prevalence of parietal cell antibody (PCA) positivity, iron deficiency anemia (IDA), and pernicious anemia (PA) were prospectively assessed in 150 DTC patients referred for radioiodine ablation after total thyroidectomy. Patients were classified as HT (n =...
Source: Endocrine - September 12, 2014 Category: Endocrinology Source Type: research

Sentinel node mapping in papillary thyroid carcinoma using combined radiotracer and blue dye methods.
CONCLUSIONS: Sentinel node mapping in papillary thyroid carcinoma is a feasible technique with high accuracy for the detection of lymph node involvement. This technique can guide surgeons to perform central lymph node dissection only in patients with pathologically involved sentinel nodes. Although SLN detection in the lateral neck lymph nodes increases the extension of lymphadenectomy, SLN mapping can result in upstaging in older patients (> 45 years of age) or treatment plan change in younger patients (< 45 years of age) by the detection of lateral lymph node involvement. (Endokrynol Pol 2014; 65 (4): 281-286). ...
Source: Endokrynologia Polska - September 8, 2014 Category: Endocrinology Authors: Assadi M, Yarani M, Zakavi SR, Jangjoo A, Memar B, Treglia G, Aliakbarian M, Mehrabibahar M, Sadeghi R Tags: Endokrynol Pol Source Type: research

Maternal Subclinical Hypothyroidism Impairs Neurodevelopment in Rat Offspring by Inhibiting the CREB Signaling Pathway
Abstract Thyroid hormone is indispensable for fetal brain development, and maternal thyroid hormone deficiency is thought to result in severe and irreversible brain impairments in learning and memory. Epidemiological and animal studies by our group had shown that maternal subclinical hypothyroidism had significant negative impact on neurodevelopment. But, the underlying mechanisms responsible for these neurological alterations remain unclear. In the present study, we performed thyroidectomy and injected L-T4 daily in Wistar rats to induce maternal subclinical hypothyroidism. Our data indicated that the pups from s...
Source: Molecular Neurobiology - September 6, 2014 Category: Neurology Source Type: research

The efficacy of radioiodine remnant ablation for differentiated thyroid cancer patients with an incomplete thyroidectomy.
CONCLUSION: Although the efficacy of RRA in DTC patients with an incomplete thyroidectomy is not as good as that of patients with a complete thyroidectomy after the first RRA, a higher ablative rate can still be achieved after the second or third RRA. PMID: 25192307 [PubMed - as supplied by publisher] (Source: Molecular Medicine)
Source: Molecular Medicine - September 5, 2014 Category: Molecular Biology Authors: Fu H, Ma C, Li J, Feng F, Wu S, Ye Z, Wang H Tags: Q J Nucl Med Mol Imaging Source Type: research