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The role of ultrasound in the follow-up of children with differentiated thyroid cancer
Conclusion US showed very good sensitivity and specificity and a high negative predictive value for evaluation of loco-regional involvement in follow-up of pediatric differentiated thyroid cancer. Diagnostic whole-body iodine scan is indicated when serum anti-thyroglobulin Ab is high, or in cases of discordant findings between US and stimulated thyroglobulin levels, or when stimulated thyroglobulin levels are >10 ng/ml (to evaluate for lung metastasis). (Source: Pediatric Radiology)
Source: Pediatric Radiology - December 19, 2014 Category: Radiology Source Type: research

Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort.
Conclusion. HT was associated with an increased prevalence of all stages of PTC, independent of tumor size, gender, and age. In contrast, locally advanced disease defined by LNM was unrelated to HT. These data suggest an association of HT with low risk PTC and a potential protective immunologic effect from further disease progression. PMID: 25505911 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 18, 2014 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Use of Radioiodine after Thyroid Lobectomy in Patients with Differentiated Thyroid Cancer: Does It Change Outcomes?
This study describes RAI utilization patterns and outcomes in patients with well-differentiated thyroid cancer (DTC) after thyroid lobectomy (TL). (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - December 17, 2014 Category: Surgery Authors: Colleen M. Kiernan, Alexander A. Parikh, Lee L. Parks, Carmen C. Solórzano Source Type: research

Surgery, Statins Linked to Lower Graves' Complication Risk Surgery, Statins Linked to Lower Graves' Complication Risk
A large study has suggested that thyroidectomy or statin use may lower the risk that patients with Graves' disease will develop thyroid-associated ophthalmopathy. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 15, 2014 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

Effect of preoperative vitamin D deficiency on postoperative hypocalcemia after thyroid surgery
Background: Transient post thyroidectomy hypocalcemia occurs in up to 30% of patients. We evaluated the effect of vitamin D deficiency on post thyroidectomy hypocalcaemia. Methods: This is a prospective study which was conducted from November 2010 to January 2013 and a total of 35 patients were included and data was analyzed regarding the relation between preoperative vitamin D3 levels and occurrence of post- thyroidectomy hypocalcemia. Patients were divided into two groups dependent upon the preoperative serum vitamin D level: group 1 with vitamin D levels =20 ng/ml. Hypocalcemia was defined as a postoperative calcium lev...
Source: Epidemiologic Perspectives and Innovations - December 15, 2014 Category: Epidemiology Authors: Mayank TripathiRajender Kumar KarwasraSanjeev Parshad Source Type: research

The utility of frozen section examination for determining extent of thyroidectomy in patients with a thyroid nodule and “atypia/follicular lesion of undetermined significance”
The purpose of this study was to evaluate the role of frozen section exam (FSE) for determining extent of thyroidectomy in patients with nodular thyroid disease and fine needle aspiration categorized as atypia/follicular lesion of undetermined significance (AFLUS). (Source: American Journal of Surgery)
Source: American Journal of Surgery - December 15, 2014 Category: Surgery Authors: S.E. Posillico, S.M. Wilhelm, C.R. McHenry Tags: Midwest Surgical Association Source Type: research

The Natural History of Benign Thyroid Nodule: What Is the Appropriate Follow-Up Strategy?
Significant numbers of benign thyroid nodules enlarge > 5 mm over 3 years, triggering repeat fine needle aspiration or thyroidectomy. Larger diameter nodules and more rapidly growing nodules were not predictive of malignancy. The practice of annually obtaining ultrasound for benign thyroid nodules should be discouraged. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - December 15, 2014 Category: Surgery Authors: Saad Ajmal, Sarah Rapoport, Haiyan Ramirez Batlle, Peter J. Mazzaglia Source Type: research

Differentiated thyroid cancer in patients over 60years of age at presentation: A retrospective study of 438 patients
Conclusion This study highlights that DTC in older patients behaves more aggressively than in adults age<60years, and identifies several prognostic factors for remission and subsequent relapse. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - December 13, 2014 Category: Cancer & Oncology Source Type: research

Thyroidectomy in a patient with thyroid storm: report of a case
Abstract Thyroid storm is a life-threatening condition that is generally considered to be a contradiction to surgical intervention. We herein describe the case of a 37-year-old patient with a history of Graves’ disease who was transferred to Tottori University Hospital with thyroid storm. She had been followed by her family doctor since 2006, but she had stopped taking her medication of her own volition in 2010. About ten days prior to her admission at our hospital, she consulted her family doctor with complaints of dyspnea, palpitations and general fatigue. Subsequent thyroid function tests showed TSH < 0...
Source: Surgery Today - December 12, 2014 Category: Surgery Source Type: research

Survival after renal cell carcinoma metastasis to the thyroid. Single center experience and systematic review of the literature.
Conclusions Time to thyroid metastasis of renal cell carcinoma can be very long, and survival after thyroidectomy is rather favorable compared to metastasis in other sites. PMID: 25491306 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 12, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Characterization of V804M-mutated RET proto-oncogene associated with familial medullary thyroid cancer, report of the largest Turkish family
Conclusions Our study revealed a relatively good prognosis in patients with V804M mutation. Despite the surgery was performed in older age no advance disease was observed. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 12, 2014 Category: Endocrinology Source Type: research

Solitary liver metastasis from follicular variant papillary thyroid carcinoma: A case report and literature review
Conclusion Rare distant sites of metastases from DTC include eyes, pharynx, skin, muscle, ovaries, adrenal glands, kidneys, esophagus, pancreas and liver. Isolated, resectable liver metastases from PTC are exceedingly rare. Literature review revealed only 10 reported cases of liver metastases from DTC. As in our patient, solitary liver metastasis from PTC should be considered for surgical resection which offers the best chance for prolonged survival. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - December 12, 2014 Category: Surgery Source Type: research

Should a family history of papillary thyroid carcinoma indicate more aggressive therapy in patients with this tumor?
Conclusion The treatment usually recommended for patients with PTC does not need to be modified in the presence of a family history of this tumor if no factors indicating a poor prognosis are present (tumor ≤2 cm, non-aggressive histology, no extensive extrathyroid invasion or important lymph node involvement, complete tumor resection, no evidence of persistent disease after surgery). Objetivo Avaliar se a terapia atualmente recomendada para o carcinoma papilífero de tireoide (CPT) sem fatores clássicos de pior prognóstico é efetiva também nos casos em que existe história familiar deste tumor. Sujeitos e métodos: ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research

IgG4-related Hashimoto’s thyroiditis – A new variant of a well known disease
We report a case of a 56-year-old Portuguese man who presented with a one-month history of progressive neck swelling and dysphagia. Laboratory testing revealed increased inflammatory parameters, subclinical hypothyroidism and very high levels of thyroid autoantibodies. Cervical ultrasound (US) demonstrated an enlarged and heterogeneous thyroid gland and two hypoechoic nodules. US-guided fine needle aspiration cytology was consistent with lymphocytic thyroiditis. The patient was submitted to total thyroidectomy and microscopic examination identified typical findings of HT, marked fibrosis limited within the thyroid capsule ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research

The Evolving Use of Radioiodine Therapy in Differentiated Thyroid Cancer
The incidence of differentiated thyroid cancer has increased worldwide over the last three decades, but thyroid cancer-related mortality remains stable. Until recently, the standard treatment for most thyroid cancers has been near-total thyroidectomy followed by radioiodine remnant ablation. Observational data support lower recurrence rates and improved survival after radioiodine ablation in patients with high-risk cancers; however, a similar benefit has not been established for all patients with thyroid cancer. Risk stratification should be used to identify patients who are likely to benefit from radioiodine ablation and ...
Source: Oncology - December 11, 2014 Category: Cancer & Oncology Source Type: research

Comparison of Therapeutic Efficacy and Clinical Parameters Between Recombinant Human Thyroid Stimulating Hormone and Thyroid Hormone Withdrawal in High-Dose Radioiodine Treatment with Differentiated Thyroid Cancer
Conclusions Consistent with previous studies, the rates of complete ablation between the THW and rh-TSH groups were not significantly different. The clinical parameters, as we mentioned above, were elevated for THW group but were irrelevant for the rh-TSH group. The findings favor HD-RIT after rh-TSH, especially for patients with chronic liver and kidney disease. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - December 11, 2014 Category: Radiology Source Type: research

The Evolving Use of Radioiodine Therapy in Differentiated Thyroid Cancer.
Abstract The incidence of differentiated thyroid cancer has increased worldwide over the last three decades, but thyroid cancer-related mortality remains stable. Until recently, the standard treatment for most thyroid cancers has been near-total thyroidectomy followed by radioiodine remnant ablation. Observational data support lower recurrence rates and improved survival after radioiodine ablation in patients with high-risk cancers; however, a similar benefit has not been established for all patients with thyroid cancer. Risk stratification should be used to identify patients who are likely to benefit from radioiod...
Source: Oncology - December 11, 2014 Category: Cancer & Oncology Authors: Mayson SE, Yoo DC, Gopalakrishnan G Tags: Oncology Source Type: research

Traction injury of the recurrent laryngeal nerve: Results of continuous intraoperative neuromonitoring in a swine model
Conclusion Traction injury of swine RLNs causes LOS at a power of 2.83 MPa. However, all injuered nerves recovered within 7days with no observed structural damage. This article is protected by copyright. All rights reserved. (Source: Head and Neck)
Source: Head and Neck - December 9, 2014 Category: ENT & OMF Authors: Hye Yoon Lee, Young Geon Cho, Ji Young You, Byoung Ho Choi, Joon Yub Kim, Che‐Wei Wu, Feng‐Yu Chiang, Hoon Yub Kim Tags: Original Article Source Type: research

Medullary Thyroid Cancer with Undetectable Serum Calcitonin.
Conclusions: We present a rare case of a patient with MTC with undetectable preoperative serum calcitonin, whose tumor demonstrated strong, diffuse immunohistochemical staining for calcitonin. We discuss the possible pathogenesis of calcitonin-negative MTC and the challenges in following patients with this condition. PMID: 25490273 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 9, 2014 Category: Endocrinology Authors: Brutsaert EF, Gersten AJ, Tassler AB, Surks MI Tags: J Clin Endocrinol Metab Source Type: research

Preoperative Imaging Modalities to Predict the Risk of Regional Nodal Recurrence in Well-Differentiated Thyroid Cancers
Conclusions Preoperative identification of lymph node metastasis on radiologic studies was correlated with an increased risk of regional nodal recurrence in well-differentiated thyroid cancer. Computed tomography was superior to ultrasonography in detecting metastatic nodal involvement preoperatively and is therefore recommended for preoperative assessment and postoperative follow-up.[...]Thieme Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)
Source: International Archives of Otorhinolaryngology - December 8, 2014 Category: ENT & OMF Authors: AlNoury, Mohammed K.Almuhayawi, Saad M.Alghamdi, Khalid B.Al-Noury, Khaled I. Tags: Original Research Source Type: research

Retrospective Analysis of 255 Papillary Thyroid Carcinomas ≤2 cm: Clinicohistological Features and Prognostic Factors
Conclusions: In the setting of small PTCs, vascular invasion, extrathyroidal extension and lymph node and/or systemic metastases may confer worse prognosis, perhaps justifying more aggressive therapeutic and follow-up approaches in such cases. (Source: European Thyroid Journal)
Source: European Thyroid Journal - December 6, 2014 Category: Endocrinology Source Type: research

Impact of Postthyroidectomy Scar on the Quality of Life of Thyroid Cancer Patients.
CONCLUSION: Post-thyroidectomy scars on the neck affect the QoL of thyroid cancer patients regardless of scar type. Therefore, clinicians should pay attention to the psychological effects of scars on patients and take care to minimize post-thyroidectomy scar. PMID: 25473220 [PubMed - as supplied by publisher] (Source: Annals of Dermatology)
Source: Annals of Dermatology - December 6, 2014 Category: Dermatology Tags: Ann Dermatol Source Type: research

Morbidity Associated with Concomitant Thyroid Surgery in Patients with Primary Hyperparathyroidism
Conclusion Patients undergoing concomitant thyroid procedures have a significantly higher risk for temporary RLN palsy and hypoparathyroidism. However, the high rate of incidentally detected thyroid carcinoma in an iodine-replete endemic goiter area indicates hemithyroidectomy in the presence of thyroid nodules incidentally identified in preoperative ultrasounds. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 6, 2014 Category: Cancer & Oncology Source Type: research

The operation experience of endoscopic thyroidectomy by areola and axilla approach
Abstract To explore the feasibility of endoscopic thyroidectomy via breast areola and axilla approach. The clinical data of 36 cases that underwent endoscopic thyroidectomy via breast areola and axilla approach from February 2012 to December 2013 were reviewed. All cases were completed, the mean operation time was 136.3 min (95–183 min), intraoperative blood loss was 15.8 ml (5–60 ml). The average hospitalization time was 5 days (4–6 days). There were no conversions to open surgery, no permanent nerve injuries, and no cases of hypoparathyroidism. Three patients had postoperative subcutaneous ecchymosis...
Source: European Archives of Oto-Rhino-Laryngology - December 6, 2014 Category: ENT & OMF Source Type: research

Myxofibrosarcoma of the thyroid gland
We report a new case which raised diagnostic and therapeutic problems. Observation We report the case of a 74-year-old woman who presented with swelling of the left thyroid lobe and ipsilateral cervical lymphadenopathy. Total thyroidectomy with cervical lymph-node dissection was performed. Histological analysis diagnosed myxofibrosarcoma. Evolution was marked by rapid local recurrence, and chemotherapy based on doxorubicin and ifosfamide was introduced. Discussion/conclusion Head and neck myxofibrosarcoma is rare. MRI is essential and should always precede treatment. Diagnosis is histological. There is elevated risk of l...
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - December 6, 2014 Category: ENT & OMF Source Type: research

Chewing-gum stimulation did not reduce the absorbed dose to salivary glands during radioiodine treatment of thyroid cancer as inferred from pre-therapy 124 I PET/CT imaging
Background: The goal of this prospective study was to estimate the absorbed (radiation) doses to salivary glands in radioiodine therapy of thyroid cancer under chewing-gum stimulation using 124I positron emission tomography (PET)/computed tomography (CT) imaging. Methods: Duplex ultrasonography was conducted in three test persons for visual comparison of the glandular blood flow with three different stimulation types (no stimulation, chewing tasteless gum base, sucking on lemon slices). Ten patients with newly diagnosed differentiated thyroid cancer received 124I PET/CT dosimetry after thyroidectomy and prior to radioiodin...
Source: EJNMMI Physics - December 6, 2014 Category: Radiology Authors: Walter JentzenMarion RichterJames NagarajahThorsten PoeppelWolfgang BrandauColin DawesAndreas BockischIna Binse Source Type: research

Association of Hashimoto's thyroiditis and thyroid cancer
Purpose of reviewThe association of Hashimoto's thyroiditis and thyroid cancer remains an active focus of research and controversy. Since it was first proposed in 1955, numerous studies have explored the epidemiology and etiology of these concurrent disease processes. Recent findingsThe lymphocytic infiltration of Hashimoto's thyroiditis is frequently encountered in thyroid glands resected for a neoplasm. The most frequent association is noted with papillary thyroid cancer. Several recent studies performed on patients undergoing thyroidectomy with coexisting Hashimoto's thyroiditis report an increased prevalence of papilla...
Source: Current Opinion in Oncology - December 5, 2014 Category: Cancer & Oncology Tags: ENDOCRINE TUMORS: Edited by Julie Ann Sosa Source Type: research

Prolonged duration of surgery is not a risk factor for postoperative complications in patients undergoing total thyroidectomy: a single center experience in 305 patients
Conclusion: Prolonged duration of surgery?>?120?minutes is not a surrogate marker for postoperative complications in patients undergoing total thyroidectomy. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - December 5, 2014 Category: Epidemiology Authors: Peter C AmbeSilvia BrömlingW T KnoefelAlexander Rehders Source Type: research

The use of semi-quantitative ultrasound elastosonography in combination with conventional ultrasonography and contrast-enhanced ultrasonography in the assessment of malignancy risk of thyroid nodules with indeterminate cytology
Conclusion The ELX 2/1 index in conjunction with the US score can be useful in orienting surgical strategies in Thy 3 nodules. The information added by CEUS is less sensitive than that provided by US and USE. The use of a cut-off based on histology can reduce thyroidectomy. Observation should be the first choice when not all instrumental results are suspect. (Source: Thyroid Research)
Source: Thyroid Research - December 5, 2014 Category: Endocrinology Source Type: research

Number of tumor foci predicts prognosis in papillary thyroid cancer
Conclusion: An increase in the number of tumors is associated with a tendency toward more aggressive features and predicts poor prognosis in PTC. (Source: BMC Cancer)
Source: BMC Cancer - December 4, 2014 Category: Cancer & Oncology Authors: Ning QuLing ZhangQing-hai JiYong-xue ZhuZhuo-ying WangQiang ShenYu WangDuan-shu Li Source Type: research

Local Recurrence in the Neck and Survival After Thyroidectomy for Metastatic Renal Cell Carcinoma
Conclusions Although significant improvement of local disease control in patients with thyroid metastases of RCC has been achieved during the last decade, overall outcome continues to be poor for patients with locally invasive thyroid metastases. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 4, 2014 Category: Cancer & Oncology Source Type: research

Endoscopic-Assisted Total Thyroidectomy via Lateral Keloid Scar Incision.
Authors: Woo SH Abstract Thyroidectomy is traditionally performed by the transcervical approach. To avoid or reduce visible scarring, diverse innovative surgical trials have been reported. Here we report a patient who underwent endoscopic thyroidectomy via a lateral keloid scar due to a previous traffic accident. A 30-year-old woman presented with a papillary thyroid carcinoma. Total thyroidectomy was performed via a keloid scar incision. The keloid scar was then revised. The total thyroidectomy was successful, resulting in no acute complications, such as neural injury, hematoma, or seroma formation. The keloid sca...
Source: Clinical and Experimental Otorhinolaryngology - December 3, 2014 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Parathyroid Gland Involvement by Thyroid Cancer: Results from a Large Series of Thyroidectomies Performed in Two Italian University Hospitals and Review of the Literature.
Conclusion. Limited to thyroidectomy series, our results and literature data suggest that parathyroid involvement by TC has a 0.4-3.9% incidence rate; mainly affects women in their sixth-seventh decade of life; is associated to a good prognosis, unless massive extrathyroid extension of TC occurs. PMID: 25436171 [PubMed - as supplied by publisher] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 3, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Can peptide receptor radionuclide therapy (PRRT) be useful in radioiodine-refractory differentiated thyroid cancer?
We report on a 70-year-old man affected by radioiodine-refractory differentiated thyroid cancer (DTC) in whom metastases were treated by peptide receptor radionuclide therapy (PRRT). Seven years before, patient had undergone total thyroidectomy. Pathological examination was conclusive for DTC. The patient underwent some radioiodine treatments (RaIT). The last post-therapy whole body scan (pT-WBS) performed five days after RaIT did not show abnormal radioiodine uptake but serum thyroglobulin (Tg) value was high in absence of thyroglobulin-antibodies (Tg-Ab). In-111 DTPA-pentetreotide scintigraphy showed several lung lesions...
Source: Endocrine - December 3, 2014 Category: Endocrinology Source Type: research

Parathyroid Allotransplant for Persistent Hypocalcaemia: A New Technique Involving Short-Term Culture.
CONCLUSIONS: Here, we report a new method, enabling fast and cost-effective parathyroid allotransplant with maintained tissue viability sufficient to treat persistent hypocalcemia. PMID: 25476143 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - December 3, 2014 Category: Transplant Surgery Authors: Aysan E, Kilic U, Gok O, Altug B, Ercan C, Kesgin Toka C, Idiz UO, Muslumanoglu M Tags: Exp Clin Transplant Source Type: research

Perigastric lymph node metastasis from papillary thyroid carcinoma in a patient with early gastric cancer: the first case report.
We present a case of perigastric lymph node metastasis from PTC in a patient with early gastric cancer and breast cancer. During post-surgical follow-up for breast cancer, a 56-year-old woman was diagnosed incidentally with early gastric cancer and synchronous left thyroid cancer. Therefore, laparoscopic distal gastrectomy with lymph node dissection and left thyroidectomy were performed. On the basis of the pathologic findings of the surgical specimens, the patient was diagnosed to have papillary thyroid microcarcinoma with perigastric lymph node metastasis and early gastric cancer with mucosal invasion. Finally, on the ba...
Source: Journal of Gastric Cancer - December 2, 2014 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Meta-analysis of recurrent laryngeal nerve injury in thyroid surgery with or without intraoperative nerve monitoring.
Authors: Rulli F, Ambrogi V, Dionigi G, Amirhassankhani S, Mineo TC, Ottaviani F, Buemi A, DI Stefano P, Mourad M Abstract Intraoperative nerve monitoring (IONM) aimed at reducing the injuries of recurrent laryngeal nerve during thyroidectomy is controversial. We conducted a meta-analysis to assess the incidence of nerve injuries with or without IONM. Studies published from January 1994 to February 2012 in English language on humans were identified. Heterogeneity of studies was checked by the Higgins test. Summary estimates of predictive values of injury were made using the Mantel-Haenszel test based on the fixed-e...
Source: Acta Otorhinolaryngologica Italica - December 2, 2014 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research

Papillary carcinoma on a thyroglossal duct cyst: diagnostic problems and therapeutic dilemma. A case report.
We present a case of papillary carcinoma arising in a thyroglossal duct cyst in 20-year-old woman with a swelling of about 4 cm, located at the middle region of the neck over the hyoid bone. Our patient was treated using a modified Sistrunk operation, in which thyroidectomy proved crucial for the correct diagnosis and continuation of appropriate treatment. Our case confirms the difficulty in distinguishing a primitive thyroglossal duct carcinoma from a synchronous metastatic papillary carcinoma of the thyroid. This dilemma often remains unresolved. PMID: 24882933 [PubMed - in process] (Source: Acta Otorhinolaryngologica Italica)
Source: Acta Otorhinolaryngologica Italica - December 2, 2014 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research

Is there a role for video-assisted parathyroidectomy in regions with high prevalence of goitre?
Authors: De Crea C, Raffaelli M, Traini E, Giustozzi E, Oragano L, Bellantone R, Lombardi CP Abstract Minimally-invasive procedures for parathyroidectomy have revolutionized the surgical treatment of primary hyperparathyroidism (pHPT). Coexistence of goitre is considered a major contraindication for these approaches, especially if unilateral. A specific advantage of video-assisted parathyroidectomy (VAP) compared to other endoscopic techniques is the possibility to combine it with thyroidectomy when necessary and when the selection criteria for video-assisted thyroidectomy (VAT) are met. We evaluated the role of VA...
Source: Acta Otorhinolaryngologica Italica - December 2, 2014 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research

Gossypiboma of the neck mimicking an isolated neck recurrence.
Authors: Kim KJ, Lim JY, Choi JS, Kim YM Abstract A gossypiboma (also called textiloma or retained surgical sponge) of the neck is rarely reported compared to intraabdominal or intrathoracic gossypibomas and also can be misdiagnosed as metastatic lymph nodes. A patient was referred to our clinic for a supraclavicular neck mass 6 months after thyroidectomy and neck dissection for papillary thyroid carcinoma in another hospital. It was initially considered an isolated neck recurrence, but it was finally diagnosed as gossypiboma by a pathological examination of the surgically-excised specimen. Characteristic findings ...
Source: Clinical and Experimental Otorhinolaryngology - December 2, 2014 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Follicular thyroid carcinoma presenting as bilateral cheek masses.
We present the case of a 46-year-old woman who had bilateral huge cheek masses that had grown rapidly over several years. Intra-oral mucosal tissue biopsy and imaging work-up including computed tomography scan and magnetic resonance imaging were performed and the initial diagnosis was presumed to be central giant cell granuloma. Incidentally detected thyroid lesions were studied with ultra-sonography guided fine needle aspiration and diagnosed as simple benign nodules. Due to continuous oral bleeding and the locally destructive feature of the lesions, we decided to excise the mass surgically. To avoid functional deficit, a...
Source: Clinical and Experimental Otorhinolaryngology - December 2, 2014 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Papillary thyroid cancer, macrofollicular variant: the follow-up and analysis of prognosis of 5 patients.
Conclusions. Although an impression of earlier and increased risk of recurrence in papillary carcinoma with macrofollicular variant has been documented, more studies with extensive follow-up times and large populations are required. PMID: 25295215 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 2, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Preablation Stimulated Thyroglobulin/TSH Ratio as a Predictor of Successful I(131)Remnant Ablation in Patients with Differentiated Thyroid Cancer following Total Thyroidectomy.
Conclusions. Preablation sTg/TSH ratio can be considered as better predictor of ablation outcome than sTg, tumor size, and capsular invasion. PMID: 24987542 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 2, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

The Morbidity of Reoperative Surgery for Recurrent Benign Nodular Goitre: Impact of Previous Unilateral Thyroid Lobectomy versus Subtotal Thyroidectomy.
Conclusions. Reoperative surgery following subtotal thyroidectomy is associated with a significantly increased risk of permanent recurrent laryngeal nerve injury and hypoparathyroidism when compared with previous unilateral thyroidectomy. Subtotal thyroidectomy should therefore no longer be recommended in the management of multinodular goitre. PMID: 24563802 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 2, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Extralaryngeal terminal division of the inferior laryngeal nerve: anatomical classification by a surgical point of view.
Conclusions. ETD of the ILN is a common anatomical variation. The bifurcation occurs in the ILN at various distances from laryngeal entry point. The classification increasing surgeons' awareness may help to simplify identification and exposure of terminal branches. Preservation of both extralaryngeal terminal branches of the ILN has paramount importance for the safety of thyroid operations. PMID: 23819101 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 2, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Is the use of a drain for thyroid surgery realistic? A prospective randomized interventional study.
Conclusions. In our experience, the use of drain for thyroid surgery is not a routine procedure. However, it should be used in the presence of extensive dead space, particularly when there is retrosternal or intrathoracic extension, or when the patient is on anticoagulant treatment. This trial was registered with clinical Trials.gov NCT01771523. PMID: 23819100 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 2, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

The identification of recurrent laryngeal nerve by injection of blue dye into the inferior thyroid artery in elusive locations.
Conclusion. The injection of blue dye into the ITA branches can be used as an alternate method in case of difficulty in identification of RLNs. PMID: 23401846 [PubMed] (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - December 2, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Thyroid surgery for elderly patients: are they at increased operative risks?
Authors: Ng SH, Wong KP, Lang BH Abstract An increasing elderly population, a rising incidence of differentiated thyroid carcinoma (DTC), and a rising incidence of benign nodular disease with age are all contributing to a rise in thyroid operations for the elderly. Literature review on the outcome and safety of thyroid surgery in elderly patients has been filled with conflicting results and this subject remains controversial. Although most single-institution studies conducted by high-volume surgeons did not find significant differences of complication rates in elderly when compared with younger cohorts, they often ...
Source: Journal of Thyroid Research - December 2, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Clinical and economic outcomes of thyroid surgery in elderly patients: a systematic review.
Authors: Sullivan MC, Roman SA, Sosa JA Abstract The U.S. population is undergoing a dramatic shift in demographics, with a rise in the proportion of elderly Americans. Given an increased prevalence of thyroid disease and malignancy with age, understanding the safety of thyroid surgery in this age group is increasingly pertinent. There remains disagreement regarding the clinical outcomes of elderly patients after thyroidectomy and the applicability of single-institution cohorts to the population at large. This paper reviews the epidemiology of thyroid disease in the elderly, current surgical indications and practic...
Source: Journal of Thyroid Research - December 2, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research

The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in the Prognostication, Diagnosis, and Management of Thyroid Carcinoma.
Authors: Lang BH Abstract 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) plays an increasingly important role in the prognostication, diagnosis, and management of thyroid carcinoma. For patients diagnosed with primary or persistent/recurrent thyroid carcinoma, a finding of FDG-PET positivity implies a more aggressive tumor biology and a distinct mutational profile, both of which carry prognostic significance. Therefore, FDG-PET positivity may be a useful potential risk factor for preoperative risk stratification in primary thyroid carcinoma. This information may help in the planning of subsequent tre...
Source: Journal of Thyroid Research - December 2, 2014 Category: Endocrinology Tags: J Thyroid Res Source Type: research