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Thyroidectomy without lateral neck dissection for papillary thyroid carcinoma with lateral neck lymph node metastases and negative intraoperative frozen section
ConclusionTotal thyroidectomy with subsequent lateral neck dissection is not necessary in patients with PTC who are diagnosed with lateral neck metastasis according to their permanent pathology report but have negative intraoperative frozen section findings. © 2014 Wiley Periodicals, Inc. Head Neck, 2015 (Source: Head and Neck)
Source: Head and Neck - July 29, 2015 Category: ENT & OMF Authors: Seok‐Mo Kim, Hyeung Kyoo Kim, Kuk‐Jin Kim, Ho Jin Chang, Bup‐Woo Kim, Yong Sang Lee, Hang‐Seok Chang, Cheong Soo Park Tags: Original Article Source Type: research

B cell-activating factor (baff) and baff receptor expression in autoimmune and non autoimmune thyroid diseases.
In this study, we report that BAFF and BAFF-R are expressed in the thyrocytes derived from patients with either AITD or MNG, in addition to the expected expression of BAFF and its receptor in the infiltrating immune cells of GD and HT. These findings suggest a possible involvement of BAFF and its receptors in the pathophysiology of AITD. PMID: 26214745 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 28, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

Papillary thyroid carcinoma (PTC) in Lynch syndrome: Report of two cases and discussion on Lynch syndrome behaviour and genetics
We present here two cases of papillary thyroid carcinoma (PTC) in patients affected by Lynch syndrome (LS). The first case is a 47-year-old woman with typical hereditary non-polyposis colorectal cancer (HNPCC) syndrome, reported with endometrial and ovarian carcinoma at age 43, and colon cancer at age 45. The patient underwent total thyroidectomy and central node dissection in 2007, at 47years old, with a histological diagnosis of PTC (T1aN1a). Molecular genetics showed a germ-line mutation of the MLH1 gene, 1858 G>T(E620X), with substitution of glycine with a stop codon at position 620. This mutation has pathogenet...
Source: Biomedicine and Pharmacotherapy - July 27, 2015 Category: Drugs & Pharmacology Source Type: research

Ultrasonographic Features of the Major Salivary Glands after Radioactive Iodine Ablation in Patients with Papillary Thyroid Carcinoma
The aim of this study was to evaluate the ultrasonographic features of the major salivary glands (MSGs) after post-operative radioactive iodine ablation (RIA) in patients with papillary thyroid carcinoma (PTC). The study population comprised 202 consecutively registered PTC patients who had undergone total thyroidectomy, RIA and follow-up neck ultrasonography. The ultrasonographic features of the MSGs in each patient were retrospectively evaluated by a single radiologist, and the presence of post-RIA changes was determined by direct comparisons of pre- and post-RIA follow-up ultrasonographic scans. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 25, 2015 Category: Radiology Authors: Dong Wook Kim Tags: Original Contribution Source Type: research

Histopathological Evidence of Lymph Node Metastasis in Papillary Thyroid Carcinoma
The objective of this study was to define histomorphological indicators of lymph node metastasis in the patients who had been performed thyroidectomy without lymph node dissection. Clinicopathological features of patients archived in Department of Pathology at Trakya University Medical Faculty were reviewed. A total of 211 patients who had been diagnosed as papillary carcinoma and had been performed total thyroidectomy/lobectomy with central/cervical lymph node dissection were included in the study. Clinical features (age, gender, preoperative/postoperative clinical, and laboratory findings) and histopathological features ...
Source: Endocrine Pathology - July 24, 2015 Category: Pathology Source Type: research

Analysis of pattern of occurrence of thyroid carcinoma between 2001 and 2010
Conclusion There is a trend for increase in thyroidectomies due to cancer in this institution, with proportional increment of cases with histopathological characteristics indicative of early disease. Among microcarcinomas, there is an increasing group represented by cancer cases that were not incidentally diagnosed, related to an enhancement in preoperative diagnostic methods. (Source: Brazilian Journal of Otorhinolaryngology)
Source: Brazilian Journal of Otorhinolaryngology - July 23, 2015 Category: ENT & OMF Source Type: research

Outcome Prediction of Treatment of Graves’ Hyperthyroidism with Antithyroid Drugs
Horm Metab ResDOI: 10.1055/s-0035-1555759Graves’ disease is the most common cause of hyperthyroidism in iodine-replete areas and is ultimately due to antibodies interacting with the TSH receptor on thyroid follicular cells [TSH-receptor antibody (TRAb)]. Antithyroid drugs (ATDs) belonging to the family of thionamides are the first-line treatment in Europe. ATD treatment is commonly continued for 18–24 months. Its major limitation is the high rate of relapses after drug withdrawal. Factors particularly bound to subsequent relapses are the large thyroid volume, smoking habit, persistence of TRAb in the circulation at the...
Source: Hormone and Metabolic Research - July 21, 2015 Category: Endocrinology Authors: Piantanida, E.Lai, A.Sassi, L.Gallo, D.Spreafico, E.Tanda, M. L.Bartalena, L. Tags: Review Source Type: research

Swollen and Ulcerated Maxillary Gingivae
A 73 year-old female was referred for evaluation of gingival lesions affecting the left maxillary quadrant. She was unsuccessfully treated with chlorhexidine mouthwash, prednisone oral rinse and penicillin. The patient had a medical history significant for hypothyroidism, hypertension, hypercholesterolemia and osteoporosis, appropriately managed with medications. Her surgical history was significant for left parotidectomy (low-grade mucoepidermoid carcinoma), thyroidectomy (Hashimoto’s thyroiditis and papillary carcinoma) and tonsillectomy. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - July 21, 2015 Category: ENT & OMF Authors: Amarpreet Sabharwal, Karthik Ganapathi, Michael N. Hatton, Alfredo Aguirre Source Type: research

Thyroid Pathology Findings in Cowden Syndrome: A Clue for the Diagnosis of the PTEN Hamartoma Tumor Syndrome.
CONCLUSIONS: Pathologists play a crucial role in recognizing pathologic thyroid findings associated with PHTS for selecting patients for genetic testing. PMID: 26185318 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2015 Category: Pathology Authors: Cameselle-Teijeiro J, Fachal C, Cabezas-Agrícola JM, Alfonsín-Barreiro N, Abdulkader I, Vega-Gliemmo A, Hermo JA Tags: Am J Clin Pathol Source Type: research

Hypoglossal nerve palsy following the robotic thyroidectomy for the papillary thyroid carcinoma; A case report
Conclusion : Although the robotic surgery is a creative technique and has been known to be safe and effective, the risk of this surgery including traumatic nerve injury should be taken into account before surgery. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - July 19, 2015 Category: Surgery Source Type: research

Comparison of quality of life between open and endoscopic thyroidectomy for papillary thyroid cancer
ConclusionCurrent findings suggest that endoscopic thyroidectomy may offer more rapid recovery of emotional and physical function than open thyroidectomy. © 2015 Wiley Periodicals, Inc. Head Neck, 2015 (Source: Head and Neck)
Source: Head and Neck - July 18, 2015 Category: ENT & OMF Authors: Myung Chul Lee, Hoon Park, Byeong‐Cheol Lee, Guk‐Haeng Lee, Ik Joon Choi Tags: Original Article Source Type: research

Potential relationship between Hashimoto's thyroiditis and BRAFV600E mutation status in papillary thyroid cancer
ConclusionHashimoto's thyroiditis was negatively associated with BRAFV600E mutation, extrathyroidal extension, and lymph node metastasis. In addition, Hashimoto's thyroiditis was related to less lymph node metastasis and extrathyroidal extension in PTCs with BRAFV600E mutation. Therefore, Hashimoto's thyroiditis is a potentially protective factor in PTC. © 2015 Wiley Periodicals, Inc. Head Neck, 2015 (Source: Head and Neck)
Source: Head and Neck - July 18, 2015 Category: ENT & OMF Authors: Rui‐chao Zeng, Lang‐ping Jin, En‐dong Chen, Si‐yang Dong, Ye‐feng Cai, Guan‐li Huang, Quan Li, Chun Jin, Xiao‐hua Zhang, Ou‐chen Wang Tags: Original Article Source Type: research

Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits.
In this study, we evaluated the effect of methimazole-induced hypothyroidism on the vascularization and immune cells infiltration into islets. A general observation of pancreas was also done. Twelve Chinchilla-breed female adult rabbits were divided into control (n = 6) and hypothyroid groups (n = 6, methimazole, 0.02% in drinking water for 30 days). After the treatment, rabbits were sacrificed and their pancreas was excised, histologically processed, and stained with Periodic Acid-Schiff (PAS) or Masson's Trichrome techniques. Islets were arbitrarily classified into large, medium, and small ones. The external and internal...
Source: International Journal of Endocrinology - July 17, 2015 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

SUVmax of 18 F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume
Background: The aim of this study was to investigate whether the maximum standardized uptake value (SUVmax) measured on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) could be used as the primary means of differential diagnosis of thyroid nodules when tumor volume is assessed. Methods: We studied 192 patients who underwent preoperative 18 F-FDG PET/CT followed by thyroidectomy. We evaluated the correlation between the volume of thyroid nodules, 18 F-FDG uptake on visual analysis, and the mean SUVmax measured...
Source: World Journal of Surgical Oncology - July 16, 2015 Category: Cancer & Oncology Authors: Tae KimYong JiChang SongJi KimYun ChoiJeong ParkKyung Tae Source Type: research

Multifocal Papillary Thyroid Cancer Increases the Risk of Central Lymph Node Metastasis.
Conclusions - There is a significant association between multifocal PTC and level VI lymph node positivity, increasing proportionally with the number of foci. These findings recognize multifocality as a sign of tumor aggressiveness, as evidenced by a higher propensity for lymph node metastasis. PMID: 26161997 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 15, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

Postoperative recurrence of papillary thyroid carcinoma with lymph node metastasis
Conclusions: In patients with PTC, the rates of recurrence and cancer mortality were higher in the group with LN metastasis than that in the intra‐thyroid tumor group. J. Surg. Oncol. © 2015 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - July 15, 2015 Category: Cancer & Oncology Authors: Feng‐Hsuan Liu, Sheng‐Fong Kuo, Chuen Hsueh, Tzu‐Chieh Chao, Jen‐Der Lin Tags: Research Article Source Type: research

Quantitative reverse transcription polymerase chain reaction–based detection of thyroid‐specific gene expression in fine‐needle aspirate for thyroid cancer recurrence evaluation: A case report and review of the literature
ConclusionThis case demonstrates a novel approach used in the evaluation for recurrent thyroid cancer as an adjunct to FNA cytology. © 2015 Wiley Periodicals, Inc. Head Neck, 2015 (Source: Head and Neck)
Source: Head and Neck - July 14, 2015 Category: ENT & OMF Authors: Saïd C. Azoury, Rachel Aufforth, Mei He, Zhiming Yang, Naris Nilubol, Electron Kebebew Tags: Case Report Source Type: research

Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer: update to study protocol with follow-up extension
ConclusionThis mixed methods extended follow-up study will provide data on long term outcomes, relating to the use of a computerized P-DA in decision-making about adjuvant RAI treatment in early stage papillary thyroid cancer.DiscussionOur results are intended to inform future research in this area, particularly relating to long term effects of the use of P-DAs in making healthcare choices.Trial registrationClinicaltrials.gov identifier NCT01083550, registered 24 February 2010 and last updated 5 January 2015 (Source: Trials)
Source: Trials - July 14, 2015 Category: Journals (General) Authors: Anna SawkaSharon StrausGary RodinKevin ThorpeShereen EzzatAmiram GafniDavid Goldstein Source Type: research

Expression of Pax8 is decreased and bortezomib does not increase the iodine uptake in thyroid carcinoma cells
Abstract Fundamental treatment for papillary thyroid carcinoma (PTC) involves total or subtotal thyroidectomy. Iodine‐131 (131I) is routinely utilized to target remnant thyroid cancer and metastasis after thyroidectomy. The effectiveness of other therapeutic modalities remains unsatisfactory; thus, these patients have a poor prognosis. The manner in which the ability of 131I uptake can be improved is vital for their prognosis. Bortezomib has been used as a re‐differentiation agent for the treatment of patients with multiple myeloma; however, little is reported about the role of bortezomib in thyroid cancer. To evaluate...
Source: Thoracic Cancer - July 14, 2015 Category: Cancer & Oncology Authors: Huan‐jun Wang, Jin‐ming Yao, Zhong‐wen Zhang, Jun‐yu Zhao, Hong‐xia Shang, Lin Liao, Jian‐jun Dong Tags: Brief Report Source Type: research

Cribriform-Morular Variant of Papillary Thyroid Carcinoma
Publication date: Available online 3 July 2015 Source:Pathology - Research and Practice Author(s): Dinesh Pradhan , Anurag Sharma , Sambit K. Mohanty Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity. This tumor is usually associated with familial adenomatous polyposis (FAP), but rarely may be sporadic. This neoplasm commonly occurs in young females. The majority of patients present with gradually enlarging painless neck mass. There is no specific imaging finding of CMV-PTC, and the diagnosis is exclusively made on pathologic examination. A multitude of cytologic features of...
Source: Pathology Research and Practice - July 14, 2015 Category: Pathology Source Type: research

Long-Term Outcomes Following Therapy in Differentiated Thyroid Carcinoma: NTCTCS Registry Analysis 1987-2012.
CONCLUSIONS: We confirm previous findings that T/NTT followed by RAI is associated with benefit in high-risk but not low-risk patients. In contrast with earlier reports, moderate THST is associated with better outcomes across all stages, and aggressive THST may not be warranted even in patients. PMID: 26171797 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 14, 2015 Category: Endocrinology Authors: Carhill AA, Litofsky DR, Ross DS, Jonklaas J, Cooper DS, Brierley JD, Ladenson PW, Ain KB, Fein HG, Haugen BR, Magner J, Skarulis MC, Steward DL, Xing M, Maxon HR, Sherman SI Tags: J Clin Endocrinol Metab Source Type: research

Clinicopathological features of recurrent papillary thyroid cancer
Background: To investigate the clinicopathological features of recurrent papillary thyroid carcinoma (PTC). Methods: A retrospective analysis on clinical and pathological data of 34 patients with recurrent PTC was carried out. A total of 281 patients with non-recurrent PTC during the same time period were chosen as the control group. Results: Patients were divided into three groups according to the pathological subtype. The number of patients belonging to Groups 1, 2, and 3 were 28, 154, and 133, respectively. 78 patients underwent partial or whole thyroidectomy, 151 cases underwent thyroidectomy combining neck regional ly...
Source: BioMed Central - July 13, 2015 Category: Journals (General) Authors: Jian ZhuXinli WangXiaoxuan ZhangPeifeng LiHaifeng Hou Source Type: research

Negative Expression of CPSF2 Predicts a Poorer Clinical Outcome in Patients with Papillary Thyroid Carcinoma.
CONCLUSION: Negative protein expression of CPSF2 is independently associated with a poor clinical outcome in PTC. CPSF2 could be a useful prognostic marker for PTC in regions with a high prevalence of the BRAFV600E mutation. PMID: 26148673 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 11, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

F18-FDG-PET for recurrent differentiated thyroid cancer: a systematic meta-analysis.
CONCLUSION: F18-FDG-PET is a useful method for detecting recurrent DTC in patients having undergone ablative therapy. PMID: 26163534 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
Source: Acta Radiologica - July 9, 2015 Category: Radiology Authors: Haslerud T, Brauckhoff K, Reisæter L, Küfner-Lein R, Heinecke A, Varhaug JE, Biermann M Tags: Acta Radiol Source Type: research

Lymph Node Metastasis from Tall-Cell Thyroid Cancer Negative on 18F-FDG PET/CT and Detected by 18F-Choline PET/CT
Abstract: A 77-year-old woman underwent thyroidectomy and 131I remnant ablation for tall-cell differentiated cancer (DTC) of the left lobe. Detectable Tg levels (4.1 μg/L) under TSH suppression, with undetectable serum Tg-antibody levels, prompted neck ultrasonography, which revealed a lymph node in the left laterocervical region and in the right retroclavicular region. 18F-FDG PET/CT showed uptake by the left lymph node. 18F-choline PET/CT showed increased uptake by both lymph nodes. Histopathology revealed DTC solid metastasis in the left lymph node and solid and cystic metastasis in the right one. 18F-choline PET/CT ca...
Source: Clinical Nuclear Medicine - July 8, 2015 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Detection of Widespread Metastasis in a Case of Aggressive Carcinoma Showing Thymuslike Differentiation (CASTLE Disease) Using 18F-FDG PET/CT
Abstract: A 30-year-old man had a diagnosis of aggressive carcinoma showing thymuslike differentiation (CASTLE disease) and underwent thyroidectomy for tumor resection and bilateral cervical lymph node dissection. Multiple hypermetabolic nodal metastases were detected in the neck and upper mediastinum with fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT). The patient received radiation therapy and chemotherapy for treatment of metastases. Follow-up 18F-FDG PET/CT demonstrated resolution of several hypermetabolic lesions previously seen in the neck, but innumerable new h...
Source: Clinical Nuclear Medicine - July 8, 2015 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Lessons learned from thyroglobulin concentrations after total thyroidectomy and radioactive iodine ablation for differentiated thyroid cancer.
PMID: 26162496 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - July 8, 2015 Category: Biochemistry Authors: Gomez-Hernandez K, Ezzat S Tags: Clin Biochem Source Type: research

Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis
Conclusion: ERAP2 might be associated with CLNM in PTMC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - July 7, 2015 Category: Cancer & Oncology Authors: Woo Young KimJae Bok LeeHoon Yub KimSang Uk WooGil Soo SonJeoung Won Bae Source Type: research

A systematic review and meta‐analysis on acoustic voice parameters after uncomplicated thyroidectomy
ConclusionF0, shimmer, and MPT significantly worsened in the early and not in the late postoperative period. F0 impairment was perceptually significant. Males and those undergoing TT suffered greater voice impairment than their counterparts during the early period. Laryngoscope, 2015 (Source: The Laryngoscope)
Source: The Laryngoscope - July 7, 2015 Category: ENT & OMF Authors: Brian H.H. Lang, Carlos K.H. Wong, Estella P.M. Ma Tags: Thyroid/Parathyroid Source Type: research

Detection of BRAF c.1799T > A (p.V600E) mutation using residual routine fine‐needle aspiration specimens of papillary thyroid carcinoma
ConclusionsDetection of BRAF p.V600E mutation can be successfully carried out using residual liquid‐based materials. It can be performed as a diagnostic tool to supplement traditional thyroid FNA, especially in cases with atypical or suspicious PTC. However, the role of BRAF p.V600E in guidance of the extent of thyroidectomy and nodal clearance requires further study. Diagn. Cytopathol. 2015. © 2015 The Authors Diagnostic Cytopathology Published by Wiley Periodicals, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - July 7, 2015 Category: Pathology Authors: Huan Zhao, Zhi‐hui Zhang, Bin Zhou, Ting Xiao, Qin‐jing Pan, Hui‐qin Guo Tags: Original Article Source Type: research

Thermal injury of the recurrent laryngeal nerve by THUNDERBEAT during thyroid surgery: findings from continuous intraoperative neuromonitoring in a porcine model
This study aimed to test the safety of TB during thyroidectomy. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - July 6, 2015 Category: Surgery Authors: Hee Yong Kwak, Gianlorenzo Dionigi, Dasom Kim, Hye Yoon Lee, Gil Soo Son, Jae Bok Lee, Jeoung Won Bae, Hoon Yub Kim Source Type: research

Evaluating hypertrophic thyroidectomy scar outcomes after treatment with triamcinolone injections and copper bromide laser therapy
ConclusionIn our study cohort, four treatments were required to reduce the VSS of thyroidectomy scars by 50% when using a combination treatment of CBL and low concentration TA ILI. Also, scar location and patient BMI are factors that affect treatment outcome. Lasers Surg. Med. © 2015 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)
Source: Lasers in Surgery and Medicine - July 6, 2015 Category: Laser Surgery Authors: Hye Rang On, Sang Hee Lee, Yong Sang Lee, Hang‐Seok Chang, CheongSoo Park, Mi Ryung Roh Tags: Clinical Report Source Type: research

Thermal injury of the recurrent laryngeal nerve by THUNDERBEAT during thyroid surgery: findings from continuous intraoperative neuromonitoring in a porcine model
This study aimed to test the safety of TB during thyroidectomy. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - July 6, 2015 Category: Surgery Authors: Hee Yong Kwak, Gianlorenzo Dionigi, Dasom Kim, Hye Yoon Lee, Gil Soo Son, Jae Bok Lee, Jeoung Won Bae, Hoon Yub Kim Source Type: research

Systematic evaluation of salivary gland damage following I-131 therapy in differentiated thyroid cancer patients by quantitative scintigraphy and clinical follow-up
Conclusion: Although the side effects associated with radioiodine treatment were apparent, they were usually small and temporary. Nevertheless, more consideration should be placed on careful dosing of I-131. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 3, 2015 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Microscopic Positive Margins in differentiated thyroid cancer is not an independent predictor of local failure.
Conclusion Patients with resectable, M0 disease that undergo total thyroidectomy have an excellent 5 year LRFS of 99.4%. Microscopic positive margin status was not a significant predictor for local failure after adjusting for ETE or pathological T stage. PMID: 26122000 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 2, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

Transient and permanent hypocalcemia after total thyroidectomy: Early predictive factors and long-term follow-up results
Post-thyroidectomy hypocalcemia is among the most common complications of total thyroidectomy. The purpose of this study was to evaluate early predictive factors and long-term changes in intact parathyroid hormone (iPTH) levels in patients with transient and permanent hypocalcemia after total thyroidectomy. (Source: Surgery)
Source: Surgery - July 2, 2015 Category: Surgery Authors: Sung Tae Seo, Jae Won Chang, Jun Jin, Young Chang Lim, Ki-Sang Rha, Bon Seok Koo Tags: Clinical Research Source Type: research

Incidentally Visualization of the Thymus on Whole-Body Iodine Scintigraphy: Report of 2 Cases and Review of the Latest Insights
Abstract: Radioiodine uptake is not commonly seen by the thymus gland. On the contrary, the gland is slowly replaced by fat after puberty. Herein, we present 2 patients with papillary thyroid carcinoma, follicular variant, and cervical lymph node involvement. After total/near-total thyroidectomy, the patients received 131I for ablation therapy. On posttreatment radioiodine scintigraphy, mediastinal 131I uptake was noted that finally was histologically/anatomically diagnosed as thymus gland uptake. It should be borne in mind as a potential cause of false-positive whole-body 131I scintigraphy. (Source: Medicine)
Source: Medicine - July 1, 2015 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Long-Term Follow-Up of the Therapeutic Outcomes for Papillary Thyroid Carcinoma With Distant Metastasis
In conclusion, after a mean follow-up of 10.1 years, the disease-specific mortality rate for PTC with DM was 70.0%. Older patients and male PTC patients with DM need more aggressive treatment. The timing of DM diagnosis did not influence disease-specific mortality. (Source: Medicine)
Source: Medicine - July 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Postoperative Complications After Prophylactic Thyroidectomy for Very Young Patients With Multiple Endocrine Neoplasia Type 2: Retrospective Cohort Analysis
Abstract: The aim of this study was to investigate whether younger age at surgery is associated with the increased incidence of postoperative complications after prophylactic thyroidectomy in pediatric patients with multiple endocrine neoplasia (MEN) 2. The shift toward earlier thyroidectomy has resulted in significantly less medullary thyroid carcinoma (MTC)-related morbidity and mortality. However, very young pediatric patients might have a higher morbidity rate compared with older patients. Hardly any literature exists on complications in the very young. A retrospective single-center analysis was performed on the outcom...
Source: Medicine - July 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Follicular variant papillary thyroid carcinoma in a pediatric population
ConclusionsIn pediatric patients ≤19 years of age, FVPTCs have intermediate tumor features compared to PTC and FTC, but a similar OS and DSS. All pediatric patients with thyroid cancer require lifelong surveillance. However, FVPTCs >4 cm may warrant closer follow‐up due to an increased risk of death. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - July 1, 2015 Category: Cancer & Oncology Authors: Jonathan Lerner, Melanie Goldfarb Tags: Research Article Source Type: research

Incidental thyroid cancer in patients undergoing total thyroidectomy for benign disease
Conclusions The result of this study show a high incidence of ITC (11.6 %). The frequency differs among patients presenting a different thyroid pathology. This is because of the small sample used in the study. Papillary carcinoma was the commonest ITC. (Source: Hellenic Journal of Surgery)
Source: Hellenic Journal of Surgery - July 1, 2015 Category: Surgery Source Type: research

Occult cancer after thyroidectomy for benign thyroid disorders. Is total thyroidectomy justified based on these grounds?
Conclusion After performing a proper workup as indicated by the guidelines, a high risk for occult thyroid cancer still remains (at least in the Greek population), which justifies the selection of total thyroidectomy for the management of benign thyroid pathologies. Only the underlying histology is associated with the presence of cancer since Hashimoto thyroiditis seems to be a risk factor. (Source: Hellenic Journal of Surgery)
Source: Hellenic Journal of Surgery - July 1, 2015 Category: Surgery Source Type: research

Recurrent laryngeal nerve safety parameters of the Harmonic Focus during thyroid surgery: Porcine model using continuous monitoring
ConclusionsThe safe distance of the HF was 1 mm, and it should be cooled for more than 10 seconds or 2 seconds after cooling on muscle. The HF should be used in a standardized manner to avoid RLN injury. Level of EvidenceNA Laryngoscope, 2015 (Source: The Laryngoscope)
Source: The Laryngoscope - July 1, 2015 Category: ENT & OMF Authors: Che‐Wei Wu, Young Jun Chai, Gianlorenzo Dionigi, Feng‐Yu Chiang, Xiaoli Liu, Hui Sun, Gregory W. Randolph, Ralph P. Tufano, Hoon Yub Kim Tags: Thyroid/Parathyroid Source Type: research

Post-thyroidectomy hypocalcemia: Impact on length of stay.
Abstract Hypocalcemia is a recognized complication following thyroid surgery. Variability in the definition of hypocalcemia and different opinions on its management can lead to unnecessary patient morbidity and longer hospital stays as a result of inappropriate or untimely treatment. Therefore, we developed a management guideline for the recognition and treatment of post-thyroidectomy hypocalcemia, and we conducted a retrospective study to assess its impact on length of stay (LOS). Between April 1, 2007, and March 31, 2009, 29 adults had undergone a total or completion thyroidectomy at our large district general ho...
Source: Ear, Nose and Throat Journal - July 1, 2015 Category: ENT & OMF Authors: Grainger J, Ahmed M, Gama R, Liew L, Buch H, Cullen RJ Tags: Ear Nose Throat J Source Type: research

High TPOAb Levels (>1300 IU/mL) Indicate Multifocal PTC in Hashimoto's Thyroiditis Patients and Support Total Thyroidectomy
Conclusion High TPOAb levels (>1300 IU/mL) are definitive indicators of multifocal PTC in HT patients, which may support surgical treatment with total thyroidectomy. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - June 29, 2015 Category: ENT & OMF Authors: Dong, S., Xia, Q., Wu, Y.-J. Tags: Endocrine Surgery Source Type: research

Oropharyngeal Contamination Predisposes to Complications after Neck Dissection: An Analysis of 9462 Patients
Conclusion Using the ACS-NSQIP data set, this study found an increased risk of surgical complications in the setting of contaminated neck dissections. These data should be used for patient risk stratification, informed consent, and to guide further research. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - June 29, 2015 Category: ENT & OMF Authors: Jain, U., Somerville, J., Saha, S., Hackett, N. J., Ver Halen, J. P., Antony, A. K., Samant, S. Tags: Head and Neck Surgery Source Type: research

Evidence‐based management of the thyroid gland during a total laryngectomy
ConclusionsTo our knowledge, this is the largest monocentric series of TGI specimens after a total laryngectomy for laryngeal neoplasms described to date. Focus must be placed on anteroinferior spread, which is likely to invade the cricothyroid membrane, because TGI is part of the extension of extralaryngeal cancer. We propose original experience‐based management of thyroid management during a total laryngectomy to improve the level of accuracy of decision making during the surgical procedure whenever possible. Level of Evidence4 Laryngoscope, 2015 (Source: The Laryngoscope)
Source: The Laryngoscope - June 25, 2015 Category: ENT & OMF Authors: Philippe Gorphe, Aïcha Ben Lakhdar, Yungan Tao, Ingrid Breuskin, François Janot, Stéphane Temam Tags: Head and Neck Source Type: research

Preventive Effect of Human Acellular Dermal Matrix on Post-thyroidectomy Scars and Adhesions: A Randomized, Double-Blinded, Controlled Trial
CONCLUSION: Acellular dermal matrix–assisted implants appear to improve post-thyroidectomy scar and swallowing impairments without delays in operation time. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - June 25, 2015 Category: Dermatology Tags: Original Article Source Type: research

Radioiodine-remnant ablation in low-risk differentiated thyroid cancer: pros
Abstract Differentiated thyroid carcinomas are typically treated with total thyroidectomy as initial therapy. Subsequent radioactive iodine (RAI) ablation destroys post-surgical thyroid remnants, can additionally provide adjuvant therapy of residual and metastatic thyroid cancers, and enhances the sensitivity and specificity of further diagnostic studies. There is current controversy regarding whether a large number of patients, broadly considered to have “low-risk” disease, should be provided RAI ablation. This is consequent to over-reliance on short-term studies, under-appreciation of the value of RAI remnan...
Source: Endocrine - June 25, 2015 Category: Endocrinology Source Type: research

Role of BRAF V600E mutation as an indicator of the extent of thyroidectomy and lymph node dissection in conventional papillary thyroid carcinoma
The extent of surgery for papillary thyroid carcinoma (PTC) is associated strongly with disease persistence, recurrence, and mortality. It is difficult, however, to determine the optimal extent for surgery. The BRAF mutation is well known for its diagnostic and prognostic value in PTC. Among the variants of PTC, the clinical importance of the BRAF mutation has been associated particularly with conventional PTC. The goal of this study was to clarify the role of the BRAF mutation as a determinant for the operative extent in conventional PTC. (Source: Surgery)
Source: Surgery - June 25, 2015 Category: Surgery Authors: Seo Ki Kim, Jung-Woo Woo, Jun Ho Lee, Inhye Park, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim Tags: Original Communication Source Type: research