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Thyroidectomy

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Minimally invasive compared with conventional thyroidectomy for nodular goitre.
Abstract Since minimally invasive thyroidectomy was introduced in 1997, different surgical approaches to the thyroid have been described: the minimal neck incision and the anterior chest, areolar breast or axillary access. Whereas conventional open thyroidectomy is suitable for any thyroid disease, minimal neck incision thyroidectomy or extracervical scarless neck thyroidectomy are limited to small-volume disease. In 11 prospective randomized studies and six systematic reviews, minimally invasive video-assisted thyroidectomy via a central or lateral neck approach afforded better cosmesis in the first 3 months than ...
Source: Clinical Breast Cancer - July 28, 2014 Category: Cancer & Oncology Authors: Dralle H, Machens A, Thanh PN Tags: Best Pract Res Clin Endocrinol Metab Source Type: research

Preoperative neck ultrasound in clinical node negative differentiated thyroid cancer.
Conclusion: Preoperative neck US detects more lateral neck disease, leading to an increase in LND with subsequent improvement in Response to Therapy and fewer return to OR for regional recurrence management. PMID: 25062456 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 25, 2014 Category: Endocrinology Authors: Wang LY, Palmer FL, Thomas D, Shaha AR, Shah JP, Patel SG, Tuttle RM, Ganly I Tags: J Clin Endocrinol Metab Source Type: research

Clinical Features and Treatment Outcomes of 41 Dogs with Sublingual Ectopic Thyroid Neoplasia
Conclusions and Clinical ImportanceWhen compared with eutopic thyroid carcinomas, ectopic sublingual thyroid tumors generally have a less aggressive biologic behavior. Many dogs have prolonged survival, even without treatment, although death because of local tumor invasiveness or metastasis can develop in some dogs. Surgical thyroidectomy, including partial hyoidectomy, is generally effective for control of local disease. Administration of radioiodine, alone or in combination with surgical treatment, is recommended for multifocal disease or metastasis. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - July 23, 2014 Category: Veterinary Research Authors: M.R. Broome, M.E. Peterson, J.R. Walker Tags: Standard Article Source Type: research

Minimally invasive compared with conventional thyroidectomy for nodular goitre
(Source: Best Practice and Research. Clinical Endocrinology and Metabolism)
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - July 19, 2014 Category: Endocrinology Authors: Henning Dralle, Andreas Machens, Phuong Nguyen Thanh Source Type: research

A staged thyroidectomy approach for gastric bypass patients
(Source: The Laryngoscope)
Source: The Laryngoscope - July 18, 2014 Category: ENT & OMF Authors: Zhen Gooi, Bryan K. Ward, David J. Mener, Ozan B. Ozgursoy, Sara I. Pai Tags: Thyroid/Parathyroid Source Type: research

BRAF V600 co-testing in thyroid FNA cytology: short-term experience in a large cancer centre in the UK
Conclusions BRAF V600 mutational analysis can enable single-stage total thyroidectomy for carcinoma if gene mutation is present in preoperative FNA. BRAF V600 co-testing may reduce the need for completion thyroidectomy with implied cost savings and lower patient morbidity associated with completion thyroidectomy when the cytology is inconclusive but where BRAF V600 mutation is identified in preoperative thyroid FNA. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - July 16, 2014 Category: Pathology Authors: Poller, D. N., Glaysher, S., Agrawal, A., Caldera, S., Kim, D., Yiangou, C. Tags: Molecular genetics, Endocrine cancer Original article Source Type: research

(11)C-Methionine PET/CT imaging of (99m)Tc-MIBI-SPECT/CT negative patients with primary hyperparathyreoidism and previous neck surgery.
Conclusion: (11)C-Methionine PET/CT is a useful complementary imaging technique to localize parathyroid adenoma or carcinoma in (99m)Tc-MIBI SPECT/CT negative patients. PMID: 25029418 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 16, 2014 Category: Endocrinology Authors: Traub-Weidinger T, Mayerhoefer ME, Koperek O, Mitterhauser M, Duan H, Karanikas G, Niederle B, Hoffmann M Tags: J Clin Endocrinol Metab Source Type: research

Anterior Mediastinal Tracheostomy as Salvage Operation.
CONCLUSIONS: Our experience with AMT as salvage therapy has shown acceptable long-term results if complete resection is achieved. This procedure is not risk free, and very careful patient selection is required because of a tortuous postoperative course, especially in combined pharyngeal-esophageal and vascular reconstruction. PMID: 25038017 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - July 15, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Berthet JP, Garrel R, Gimferrer JM, Paradela M, Marty-Ané CH, Molins L, Gómez-Caro A Tags: Ann Thorac Surg Source Type: research

Effect of clinical nursing pathway for endoscopic thyroidectomy in Chinese patients: A meta‐analysis
The aim of this study was to assess the effect of the use of a clinical nursing pathway for patients undergoing endoscopic thyroidectomy by conducting a meta‐analysis. Electronic databases were searched for relevant controlled trials published prior to August 2013. Only papers that compared the use of a clinical nursing pathway to usual care for patients undergoing endoscopic thyroidectomy were selected. The outcome measures were mean difference and 95% confidence interval for length of hospital stay and hospital charges and risk ratio for patient satisfaction. Six controlled trials were identified. The use of a clinical...
Source: International Journal of Nursing Practice - July 11, 2014 Category: Nursing Authors: Yu Yang, Xinhua Hu, Qiang Zhang, Hui Cao, Jun Li, Junpeng Wang, Yang Shao, Shijie Xin Tags: Research Paper Source Type: research

Relationship between hypoparathyroidism and the number of parathyroid glands preserved during thyroidectomy
Conclusions: Preservation of all parathyroid glands decreases transient hypoparathyroidism compared with when three or fewer glands are preserved, but does not affect permanent hypoparathyroidism. During total thyroidectomy, preserving at least one parathyroid gland with an intact blood supply appears to be sufficient to prevent permanent hypoparathyroidism when autotransplantation is not performed. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - July 7, 2014 Category: Cancer & Oncology Authors: Chang Myeon SongJoo Hwan JungYong Bae JiHyun Jung MinYou Hern AhnKyung Tae Source Type: research

The utility of BRAF mutation detection in fine‐needle aspiration biopsy samples read as “suspicious for papillary thyroid carcinoma”
Conclusions: BRAF testing is a useful adjunct to improve PPV for patients with suspicious for PTC cytology. Head Neck, 2014 (Source: Head and Neck)
Source: Head and Neck - July 3, 2014 Category: ENT & OMF Authors: Sebastian M. Jara, Ramneesh Bhatnagar, Hui Guan, Christopher D. Gocke, Syed Z. Ali, Ralph P. Tufano Tags: Original Article Source Type: research

Robotic thyroidectomy learning curve for beginning surgeons with little or no experience of endoscopic surgery
Conclusions: The surgical learning curve for robotic thyroidectomy performed by recently graduated fellowship‐trained surgeons with little or no experience in endoscopic surgery showed excellent results compared with those in a large series of more experienced surgeons. Head Neck, 2014 (Source: Head and Neck)
Source: Head and Neck - July 2, 2014 Category: ENT & OMF Authors: Jae Hyun Park, Jandee Lee, Nor Azham Hakim, Ha Yan Kim, Sang‐Wook Kang, Jong Ju Jeong, Kee‐Hyun Nam, Keum‐Seok Bae, Seong Joon Kang, Woong Youn Chung Tags: Original Article Source Type: research

Pyramidal lobe decreases endogenous TSH stimulation without impact on radio-iodine therapy outcome in patients with differentiated thyroid cancer.
CONCLUSION: Pyramidal lobe decreases endogenous TSH stimulation without impact on radio-iodine therapy outcome in patients with DTC. PMID: 24997767 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - July 2, 2014 Category: Endocrinology Authors: Sawicka-Gutaj N, Klimowicz A, Sowinski J, Oleksa R, Gryczynska M, Wyszomirska A, Czarnywojtek A, Ruchala M Tags: Ann Endocrinol (Paris) Source Type: research

Pathologic spectrum of lymphocytic infiltration and recurrence of papillary thyroid carcinoma.
CONCLUSION: There was no relationship between PTC prognosis and different grades of LT. Pathologic tumor size and taller than wide shape on ultrasound were independent predictors of PTC recurrence regardless of concurrent LT. PMID: 24954314 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 28, 2014 Category: Universities & Medical Training Authors: Kim HG, Kim EK, Han KH, Kim H, Kwak JY Tags: Yonsei Med J Source Type: research

mRNA-SEQ REVEALS NOVEL MOLECULAR MECHANISMS AND A ROBUST FINGERPRINT IN GRAVES' DISEASE.
Conclusions: These data reveal an active immune defense system in Graves' disease which involves novel molecular mechanisms in its pathogenesis and development. PMID: 24971664 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - June 27, 2014 Category: Endocrinology Authors: Yin X, Sachidanandam R, Morshed S, Latif R, Shi R, Davies TF Tags: J Clin Endocrinol Metab Source Type: research

Prophylactic thyroidectomy: Who needs it, when, and why
The most common hereditary thyroid cancer is medullary thyroid cancer, which can be associated with MEN 2A, MEN 2B, or FMTC. In these patients, prophylactic thyroidectomy is recommended; timing of surgery is dependent on the specific RET mutation. Prophylactic thyroidectomy should include total thyroidectomy and accompanying central compartment neck dissection should be done for patients at high risk for micro‐metastatic disease only. Surgery should be performed at tertiary care institutions by high‐volume thyroid surgeons. J. Surg. Oncol. © 2014 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - June 25, 2014 Category: Cancer & Oncology Authors: Tracy S. Wang, Adwoa Opoku‐Boateng, Sanziana A. Roman, Julie Ann Sosa Tags: Review Article Source Type: research

Sutureless thyroidectomy
(Source: International Journal of Surgery)
Source: International Journal of Surgery - June 25, 2014 Category: Surgery Authors: Roberto Ruggiero, Adelmo Gubitosi, Giovanni Conzo, Simona Gili, Alfonso Bosco, Raffaele Pirozzi, Cosma Cosenza, Gianluca Rossetti, Landino Fei, Giovanni Docimo, Ludovico Docimo Source Type: research

Early biomarkers of hypocalcemia following total thyroidectomy
(Source: International Journal of Surgery)
Source: International Journal of Surgery - June 24, 2014 Category: Surgery Authors: A. Bove, R.M. Di Renzo, G. Palone, V. D'Addetta, R. Percario, P. Panaccio, G. Bongarzoni Source Type: research

Coexistence of Papillary Thyroid Cancer and Hashimoto Thyroiditis in Children: Report of 3 Cases
This report documents 3 pediatric papillary thyroid carcinoma cases with associated Hashimoto thyroiditis. In all 3 cases, hypoechoic nodules accompanied by multiple echogenic spots were noted on sonography of the thyroid. Hashimoto thyroiditis was suspected on the basis of positive thyroid autoantibody test results and pathologic examinations of thyroidectomy specimens, which revealed chronic thyroiditis with lymphocytic infiltration as the background of papillary thyroid carcinoma development. The potential for papillary carcinoma development warrants close follow-up, and meticulous sonographic examinations must be perfo...
Source: Journal of Ultrasound in Medicine - June 23, 2014 Category: Radiology Authors: Koibuchi, H., Omoto, K., Fukushima, N., Toyotsuji, T., Taniguchi, N., Kawano, M. Tags: Case Series Source Type: research

The safety of the Harmonic FOCUS in open thyroidectomy: A prospective, randomized study comparing the Harmonic FOCUS and traditional suture ligation (knot and tie) technique
(Source: International Journal of Surgery)
Source: International Journal of Surgery - June 23, 2014 Category: Surgery Authors: Antonio Zanghì, Andrea Cavallaro, Maria Di Vita, Francesco Cardì, Paolo Di Mattia, Gaetano Piccolo, Giuseppina Barbera, Mario Urso, Alessandro Cappellani Source Type: research

Diagnostic Accuracy and Interobserver Agreement of Quasistatic Ultrasound Elastography in the Diagnosis of Thyroid Nodules.
Conclusion: QUE provides accurate quantitative evaluation of thyroid nodules with low interobserver variability. PMID: 24955842 [PubMed - as supplied by publisher] (Source: Ultraschall in der Medizin)
Source: Ultraschall in der Medizin - June 23, 2014 Category: Radiology Authors: Cantisani V, Lodise P, Di Rocco G, Grazhdani H, Giannotti D, Patrizi G, Medvedyeva E, Olive M, Fioravanti C, Giacomelli L, Chiesa C, Redler A, Catalano C, D'Ambrosio F, Ricci P Tags: Ultraschall Med Source Type: research

Relationship between postoperative venous thromboembolism and hemorrhage in patients undergoing total thyroidectomy without preoperative prophylaxis
(Source: International Journal of Surgery)
Source: International Journal of Surgery - June 21, 2014 Category: Surgery Authors: Paolo Limongelli, Salvatore Tolone, Adelmo Gubitosi, Gianmattia del Genio, Giuseppina Casalino, Vincenzo Amoroso, Landino Fei, Giampaolo Jannelli, Luigi Brusciano, Giovanni Docimo, Ludovico Docimo Source Type: research

Is it possible to predict the need for sternotomy in patients undergoing thyroidectomy with retrosternal extension?
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was ‘in patients undergoing thyroidectomy for retrosternal goitre, what factors predict sternotomy?’ Altogether 165 papers were found as a result of the reported search, of which only 3 prospective studies, 1 review paper and 2 retrospective studies represented the best evidence to answer the clinical question. The authors, journals, date and country of publication, patient group studied, study type, relevant outcomes and results of the papers are tabulated. We conclude that a combination of preopera...
Source: Interactive CardioVascular and Thoracic Surgery - June 18, 2014 Category: Cardiovascular & Thoracic Surgery Authors: McKenzie, G. A. G., Rook, W. Tags: Adult Cardiac Source Type: research

A Single Parathyroid Hormone Level Obtained 4 hours after Total Thyroidectomy Predicts the Need for Postoperative Calcium Supplementation
(Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - June 18, 2014 Category: Surgery Authors: Azadeh A. Carr, Tina W. Yen, Gilbert G. Fareau, Ashley K. Cayo, Sarah M. Misustin, Douglas B. Evans, Tracy S. Wang Source Type: research

A Rapid and Accurate Technique for the Identification of the Recurrent Laryngeal Nerve.
CONCLUSION: Using the third ring as guidance, our inferior-superior technique offers an extra benefit in identifying the RLN safely and quickly, as compared to the conventional inferior approach. PMID: 24944276 [PubMed - as supplied by publisher] (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - June 18, 2014 Category: ENT & OMF Authors: Liu SC, Chou YF, Su WF Tags: Ann Otol Rhinol Laryngol Source Type: research

Complications After Tracheal and Cricotracheal Resection and Anastomosis for Inflammatory and Neoplastic Stenoses.
CONCLUSION: Even though the overall success rate of TRA/CTRA is high, it should always be regarded as a major surgical procedure with a non-negligible incidence of complications. PMID: 24944273 [PubMed - as supplied by publisher] (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - June 18, 2014 Category: ENT & OMF Authors: Piazza C, Del Bon F, Paderno A, Grazioli P, Mangili S, Lombardi D, Nicolai P, Peretti G Tags: Ann Otol Rhinol Laryngol Source Type: research

Total thyroidectomy with harmonic scalpel combined to gelatin-thrombin matrix hemostatic agent: Is it safe and effective? A single-center prospective study
(Source: International Journal of Surgery)
Source: International Journal of Surgery - June 18, 2014 Category: Surgery Authors: Giovanni Docimo, Salvatore Tolone, Roberto Ruggiero, Gianmattia del Genio, Luigi Brusciano, Angela Pezzolla, Gianpaolo Jannelli, Alfonso Bosco, Domenico Parmeggiani, Cosmo Cosenza, Paolo Limongelli, Ludovico Docimo Source Type: research

A Single Parathyroid Hormone Level Obtained 4 Hours after Total Thyroidectomy Predicts the Need for Postoperative Calcium Supplementation
(Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - June 18, 2014 Category: Surgery Authors: Azadeh A. Carr, Tina W. Yen, Gilbert G. Fareau, Ashley K. Cayo, Sarah M. Misustin, Douglas B. Evans, Tracy S. Wang Source Type: research

Loss of ERβ expression in papillary thyroid carcinoma is associated with recurrence in young female
ConclusionLoss of ERβ expression was associated with recurrence in young female PTC patients. This finding suggests that oestrogen might play a protective role in the progression of PTC via ERβ, especially in young female patients. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - June 17, 2014 Category: Endocrinology Authors: Hwa Young Ahn, Min Suk Kim, Min Joo Kim, Soo Youn Cho, Young A Kim, Guk Haeng Lee, Byeong‐Cheol Lee, Young Joo Park, Ka Hee Yi Tags: Original Article Source Type: research

Modified robotic‐assisted thyroidectomy: An initial experience with the retroauricular approach
ConclusionsSingle‐incision retroauricular robotic hemithyroidectomy can be a safe and feasible alternative to other remote access techniques. Neck lift surgery can be performed safely in a select group of patients. However, future studies are warranted to further evaluate the benefits and limitations of this novel approach. Level of Evidence4. Laryngoscope, 2014 (Source: The Laryngoscope)
Source: The Laryngoscope - June 16, 2014 Category: ENT & OMF Authors: Emad Kandil, Ahmad Saeed, Salah Eldin Mohamed, Nuha Alsaleh, Rizwan Aslam, Thomas Moulthrop Tags: Thyroid/Parathyroid Source Type: research

Predictive factors for intraoperative excessive bleeding in Graves' disease.
CONCLUSION: A huge goiter presented as a predictive factor for excessive bleeding during surgery for Graves' disease, and preparation for blood transfusion should be considered in cases where thyroids weigh more than 200 g. PMID: 24938857 [PubMed - as supplied by publisher] (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - June 14, 2014 Category: Surgery Authors: Yamanouchi K, Minami S, Hayashida N, Sakimura C, Kuroki T, Eguchi S Tags: Asian J Surg Source Type: research

Thyroidectomy in patients with a high BMI: a safe surgery?
CONCLUSION: Despite the longer operative time, thyroidectomy (total or partial) can be performed safely in patients with a BMI ≥25. PMID: 24913199 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 12, 2014 Category: Endocrinology Authors: Finel JB, Mucci S, Branger F, Venara A, Lenaoures P, Rodien P, Hamy A Tags: Eur J Endocrinol Source Type: research

Effect of UGT1A1, UGT1A3, DIO1 and DIO2 polymorphisms on L‐thyroxine doses required for TSH suppression in patients with differentiated thyroid cancer
ConclusionUGT1A haplotypes associate with T4 dosage in DTC patients, but the effect accounts for only 2% of the total variability and recommendation of preemptive UGT1A genotyping is not warranted. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - June 9, 2014 Category: Drugs & Pharmacology Authors: Ana B Santoro, Daniela D. Vargens, Mateus de Camargo Barros Filho, Daniel A. Bulzico, Luiz Paulo Kowalski, Ricardo M. R. Meirelles, Daniela P. Paula, Ronaldo R.S. Neves, Cencita N. Pessoa, Claudio J Struchine, Guilherme Suarez‐Kurtz Tags: Pharmacogenetics Source Type: research

Robotic thyroidectomy using bilateral axillo‐breast approach: Comparison of surgical results with open conventional thyroidectomy
ConclusionsRobotic thyroidectomy using BABA may be a technically feasible and safe procedure comparable to conventional open surgery especially in node‐negative patients. J. Surg. Oncol. © 2014 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - June 5, 2014 Category: Cancer & Oncology Authors: Hee Yong Kwak, Hoon Yub Kim, Sinil Kim, Hye Yoon Lee, Seung Pil Jung, Sang Uk Woo, Gil Soo Son, Jae Bok Lee, Jeoung Won Bae Tags: Research Article Source Type: research

Update on Differentiated Thyroid Cancer Staging
In this review, we demonstrate how initial estimates of the risk of disease-specific mortality and recurrent/persistent disease should be used to guide initial treatment recommendations and early management decisions and to set appropriate patient expectations with regard to likely outcomes after initial therapy of thyroid cancer. The use of ongoing risk stratification to modify these initial risk estimates is also discussed. Novel response to therapy definitions are proposed that can be used for ongoing risk stratification in thyroid cancer patients treated with lobectomy or total thyroidectomy without radioactive iodine ...
Source: Endocrinology and Metabolism Clinics of North America - June 1, 2014 Category: Endocrinology Authors: Denise P. Momesso, R. Michael Tuttle Source Type: research

Alternative Approaches to the Thyroid Gland
Advances in surgical technology and patient-driven demands have fueled exploration into methods to improve cosmetic outcomes in thyroid surgery. This exploration has produced 2 fundamentally different pathways for reducing the visible thyroidectomy scar. Minimally invasive anterior cervical approaches use small incisions hidden in natural skin creases and reduce the overall extent of dissection required to remove the thyroid. Remote access approaches remove the incision from the anterior neck completely but require more extensive dissection to access the thyroid compartment. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - June 1, 2014 Category: Endocrinology Authors: William S. Duke, David J. Terris Source Type: research

Robotic Thyroidectomy
Robotic thyroidectomy is ideal for patients with indeterminate, likely benign lesions less than 3 cm, and a body mass index less than 35 kg/mg2. Proper arm position and padding are important to facilitate exposure and development of the working space from axilla to thyroid bed. The working space is developed using headlight and retractors without robotic assistance, establishing exposure of the thyroid bed from a 5-cm incision in the axilla. Three robotic instruments and a stereoscopic endoscope provide excellent visualization of the associated thyroid neurovasculature anatomy. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - June 1, 2014 Category: ENT & OMF Authors: F. Christopher Holsinger, Woong Youn Chung Source Type: research

[Intestinal bleeding and obstruction in the small intestine caused by metastatic thyroid angiosarcoma. Case report].
Abstract The authors present a case of a primary angiosarcoma of the thyroid gland with an intestinal metastasis. The 59-year-old female patient with tarry stool and anemia was referred to the outpatient hospital. Her past history included a thyroid "cold" nodule. Gastroscopy and colonoscopy failed to identify the origin of gastrointestinal bleeding, however, capsule endoscopy verified synchronous tumors in the small intestine. The distal tumor showed signs of bleeding and caused bowel obstruction. An urgent operation was performed and the tumorous part of the ileum was resected. Histology of the removed specimen i...
Source: Orvosi Hetilap - June 1, 2014 Category: Journals (General) Authors: Benis E, Szilágyi A, Izbéki F, Varga I, Altorjay A Tags: Orv Hetil Source Type: research

How to Manage Patients with Differentiated Thyroid Cancer and a Rising Serum Thyroglobulin Level.
Abstract Serum thyroglobulin (sTg) is the marker for monitoring persistence/recurrence of differentiated thyroid cancer, in patients without sTg antibodies. Patients with undetectable basal sTg or peak sTg <2 ng/mL are cured with low risk to recur. Newly detectable level of sTg indicates the recurrence. The significance of increasing sTg in patients treated with emithyroidectomy or total-thyroidectomy but not ablated with radioiodine is undefined. A doubling time <1 year may be a poor prognostic factor, but this is more relevant in cases with high levels of sTg. Because of its sensitivity, neck ultrasound sho...
Source: The Medical Clinics of North America - June 1, 2014 Category: Journals (General) Authors: Elisei R, Agate L, Viola D, Matrone A, Biagini A, Molinaro E Tags: Endocrinol Metab Clin North Am Source Type: research

Microscope‐assisted thyroidectomy: our experience in one hundred and twenty‐one consecutive cases
This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - June 1, 2014 Category: ENT & OMF Authors: SP Williams, MD Wilkie, J Tahery Tags: Our Experience Source Type: research

Prophylactic Central Compartment Neck Dissection for Papillary Thyroid Cancer.
Abstract Prophylactic central compartment neck dissection (pCCND) is a CCND in patients with thyroid cancer who have no clinical, sonographic, or intraoperative evidence of abnormal lymph nodes. Whether pCCND should be performed in all patients with clinically node-negative papillary thyroid cancer (PTC) is controversial. Existing data reveal that for patients with clinically node-negative PTC there is no difference between treatment with total thyroidectomy plus pCCND and total thyroidectomy alone. The potential increased risk of hypoparathyroidism associated with CCND is not offset by any measurable oncologic ben...
Source: The Surgical Clinics of North America - May 30, 2014 Category: Surgery Authors: McHenry CR, Stulberg JJ Tags: Surg Clin North Am Source Type: research

Examining National Outcomes after Thyroidectomy with Nerve Monitoring
(Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - May 29, 2014 Category: Surgery Authors: Thomas K. Chung, Eben L. Rosenthal, John R. Porterfield, William R. Carroll, Joshua Richman, Mary T. Hawn Source Type: research

Utility of serum thyroglobulin measurements after prophylactic thyroidectomy in patients with hereditary medullary thyroid cancer
(Source: Surgery)
Source: Surgery - May 29, 2014 Category: Surgery Authors: Carolyn D. Seib, Avital Harari, Felix A. Conte, Quan-Yang Duh, Orlo H. Clark, Jessica E. Gosnell Source Type: research

Examining National Outcomes after Thyroidectomy with Nerve Monitoring
(Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - May 29, 2014 Category: Surgery Authors: Thomas K. Chung, Eben L. Rosenthal, John R. Porterfield, William R. Carroll, Joshua Richman, Mary T. Hawn Source Type: research

Commentary on: A prospective comparison of patient body image after robotic thyroidectomy and conventional open thyroidectomy in patients with papillary thyroid carcinoma
(Source: Surgery)
Source: Surgery - May 27, 2014 Category: Surgery Authors: Geoffrey B. Thompson Tags: Original Communications Source Type: research

The rare intracellular RET mutation p.S891A in a Chinese Han family with familial medullary thyroid carcinoma.
We report intracellular RET mutation in a Han Chinese pedigree with familial medullary thyroid carcinoma (FMTC). Direct sequencing of RET proto-oncogene identified a missense c.2671T greater than G (p.S891A) mutation in 6 of 14 family members. The single nucleotide polymorphisms c. 135A greater than G (p.A45A), IVS4 + 48A greater than G, c. 1296A greater than G (p.A432A), c. 2071G greater than A (p.G691S), c. 2307T greater than G (p.L769L) and a variant c. 833C greater than A (p.T278N) were also found in 6 carriers. Among 5 of the 6 carriers presented medullary thyroid carcinoma (MTC) as an isolated clinical phenotype, wit...
Source: Journal of Biosciences - May 26, 2014 Category: Biomedical Science Authors: Qi XP, Zhang RX, Cao JL, Chen ZG, Jin HY, Yang RR Tags: J Biosci Source Type: research

Reporting thyroid FNA before and after implementation of the Bethesda system—One institution's experience
This study evaluates the impact of the Bethesda System on the rate and the positive predictive value (PPV) of the diagnostic categories at BIDMC. We performed a retrospective review of all thyroid fine‐needle aspirations (FNAs) during the time periods January, 2006 to November, 2008 and June, 2010 to July, 2011 and the subsequent thyroidectomy specimens. Post‐Bethesda System, diagnoses that are equivocal for diverse reasons and which have wide‐ranging PPVs are now all grouped into the AUS category, and the proportion of cases that are in the atypical/AUS category rose from 3.7% in the pre‐Bethesda period to 12% in ...
Source: Diagnostic Cytopathology - May 26, 2014 Category: Pathology Authors: Kathriel J. Brister, Remmi S. Singh, Helen H. Wang Tags: Original Article Source Type: research

When would we advocate a total thyroidectomy in cases of hypopharyngeal carcinoma?
CONCLUSION: We would advocate a total thyroidectomy in cases of advanced stages of hypopharyngeal carcinoma, bilateral tumors, postcricoid carcinoma and in all patients with definite radiological evidence of thyroid gland invasion. PMID: 24841160 [PubMed - in process] (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - May 24, 2014 Category: Cancer & Oncology Authors: Gad Z, Mohamed A, Fakhr I Tags: J Egypt Natl Canc Inst Source Type: research

Vascular smooth muscle cell apoptosis is an early trigger for hypothyroid atherosclerosis
Conclusion These findings provide an in vivo example for VSMC apoptosis as an early trigger of hypothyroidism-associated atherosclerosis, and reveal activation of TRα1 receptors to prevent VSMC apoptosis as a therapeutic strategy in this disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 22, 2014 Category: Cardiology Authors: Wang, P., Xu, T.-Y., Guan, Y.-F., Zhao, Y., Li, Z.-Y., Lan, X.-H., Wang, X., Yang, P.-Y., Kang, Z.-M., Vanhoutte, P. M., Miao, C.-Y. Tags: Vascular biology Source Type: research