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Postoperative PTH monitoring of hypocalcemia expedites discharge after thyroidectomy
Conclusions Postoperative PTH level after total thyroidectomy facilitates early supplementation therapy and abates symptomatic hypocalcemia. It also allows early and safe patient discharge. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - November 28, 2014 Category: Endocrinology Source Type: research

Incidental papillary thyroid carcinoma: Clinical characteristics and prognostic factors among patients with Graves’ disease and euthyroid goiter, Cleveland Clinic experience
Conclusion The prevalence of incidental DTC in GD is comparable to EG. Each is increased compared to general population. Age of presentation of PTC was significantly lower in GD suggesting an increased risk for MPTC in GD. Nodule size greater than 1cm predicted incidental DTC whereas TSI ab titers and disease duration did not. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - November 28, 2014 Category: Endocrinology Source Type: research

Is thyroid gland only a “land” for primary malignancies? role of morphology and immunocytochemistry
ConclusionsFNAC empowered the diagnostic workup of patients with TM avoiding useless surgical approach. The low sensitivity of cytology might be reinforced by the application of ancillary techniques. In contrast with the reported predominant rate of kidney metastatic carcinomas, our findings underlined that intestinal cancer as well as lung and breast are the most common TM. TM are frequently multifocal and in a contest of a systemic disease so that a tailored therapy seems to be the best treatment Diagn. Cytopathol. 2014. © 2014 Wiley Periodicals, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 27, 2014 Category: Pathology Authors: Esther Diana Rossi, Maurizio Martini, Patrizia Straccia, Rene Gerhard, Antonella Evangelista, Alfredo Pontecorvi, Guido Fadda, Luigi Maria Larocca, Fernando Schmitt Tags: Original Article Source Type: research

Recurrence in regional lymph nodes after total thyroidectomy and neck dissection in patients with papillary thyroid cancer
We investigated the risk factors of the regional lymph node (LN) recurrence in papillary thyroid cancer (PTC) patients underwent thyroidectomy and neck dissection according to the clinicopathologic features, preoperative clinical nodal status and the recurrence in previously dissected or undissected compartment of the neck. (Source: Oral Oncology)
Source: Oral Oncology - November 27, 2014 Category: Cancer & Oncology Authors: Ji-young Joo, Jun Jin, Sung Tae Seo, Young Chang Lim, Ki-Sang Rha, Bon Seok Koo Source Type: research

Should small papillary thyroid cancer be observed? A population‐based study
CONCLUSIONSBecause 12.3% of patients who experienced TC‐related deaths had PTCs ≤2 cm despite undergoing thyroidectomy, the current results indicate that nonoperative management for patients who have PTCs ≤2 cm should be used with caution. Patients aged ≥45 years with PTCs ≤2 cm should undergo thyroidectomy. Cancer 2014. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. (Source: Cancer)
Source: Cancer - November 25, 2014 Category: Cancer & Oncology Authors: Naris Nilubol, Electron Kebebew Tags: Original Article Source Type: research

Thyroid cancer & sarcoidosis.
CONCLUSION: Clinicians should be wary of this association/co-existence of SA and PTC to avoid mismanagement of neck lymphadenopathies in patients with current or history of SA. Although 4% of thyroid cancers may induce a sarcoid reaction in the thyroid gland, SA as a disease may coexist with PTC although causality remains uncertain. Being aware of this association is important in the differential diagnosis of a thyroid mass and/or a LN in a patient with SA. Therefore, patients with known SA who are found to have cervical adenopathies or thyroid nodules should have a thorough work up. PMID: 25363225 [PubMed - in process...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Superior laryngeal nerve monitoring using laryngeal surface electrodes and intraoperative neurophysiological monitoring during thyroidectomy
The objective of this study is to establish normative waveform data for the external branch of the superior laryngeal nerve (SLN) utilizing laryngeal surface electrodes and intraoperative neurophysiological monitoring (IONM) in conjunction with a clinical neurophysiologist. A retrospective chart review of 91 consecutive at‐risk SLN were identified in 51 patients in whom IONM using laryngeal surface electrodes was performed by a clinical neurophysiologist using Dragonfly (Neurovision Medical Products, Ventura, CA) recording electrodes and a Protektor (Natus Medical Inc., San Carlos, CA)16 channel‐ intraoperative nerve m...
Source: Clinical Anatomy - November 25, 2014 Category: Anatomy Authors: Benjamin L. Hodnett, Nicole C. Schmitt, Daniel R. Clayburgh, Alex Burkowsky, Jeffrey Balzer, Parthasarathy D. Thirumala, Umamaheswar Duvvuri Tags: Original Communication Source Type: research

Association between idiopathic retroperitoneal fibrosis and autoimmune thyroiditis: A case–control study
Conclusions IRF patients have a higher risk of HT compared to controls. Thyroid function should be monitored in patients with IRF. (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - November 25, 2014 Category: Allergy & Immunology Source Type: research

Concurrent Medullary, Papillary, and Follicular Thyroid Carcinomas and Simultaneous Cushing's Syndrome
Conclusion: We present a rare case of a patient with follicular, papillary, and medullary thyroid carcinoma, and Cushing's syndrome. To date, no known genetic mutation or syndrome can account for this combination of neoplastic thyroid and adrenal pathologies, although future research may prove differently.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 22, 2014 Category: Endocrinology Source Type: research

Erratum: Validation of 1-hour post-thyroidectomy parathyroid hormone level in predicting hypocalcemia
No abstract (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - November 20, 2014 Category: Epidemiology Authors: Trung N LePaul D KerrDonna E SutherlandPascal Lambert Source Type: research

Midkine Concentrations in Fine‐Needle Aspiration of Benign and Malignant Thyroid Nodules
ConclusionsThe findings indicate that, in FNA samples, the MDK/Tg ratio in PTC is greater than in benign thyroid nodules, raising the possibility that this approach might provide adjunctive diagnostic or prognostic information to complement existing approaches.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - November 20, 2014 Category: Endocrinology Authors: Youn Hee Jee, Francesco S. Celi, Maureen Sampson, Sacks David B, Alan T. Remaley, Electron Kebebew, Jeffrey Baron Tags: Original Article Source Type: research

Pediatric thyroidectomy in a high volume thyroid surgery center: Risk factors for postoperative hypocalcemia
Hypocalcemia is a common complication following thyroid surgery. We seek to report on our experience in pediatric thyroidectomy in a high volume thyroid surgery center and accurately assess the incidence of postoperative hypocalcemia. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - November 19, 2014 Category: Surgery Authors: Yufei Chen, Peter T. Masiakos, Randall D. Gaz, Richard A. Hodin, Sareh Parangi, Gregory W. Randolph, Peter M. Sadow, Antonia E. Stephen Source Type: research

Modification of two-incision trans-axillary robotic thyroidectomy
We describe two patients who underwent TART using a trans-axillary incision and a separate 1 cm incision in the anterior axilla 2.5-cm below the trans-axillary incision for placement of the fourth arm. This design allowed for a more ergonomic placement of the fourth arm while not compromising the working space provided by the trans-axillary incision. Additionally this port was used for surgical drain placement Robot-assisted trans-axillary thyroidectomy poses several challenges in the early surgical learning curve. One roadblock to exposure and efficiency is appropriate port and arm placement. Our modification offers an a...
Source: Journal of Robotic Surgery - November 18, 2014 Category: Surgery Source Type: research

Retroperitoneal Bronchogenic Cyst Presenting Paraadrenal Tumor Incidentally Detected by 18 F-FDG PET/CT
Abstract A follow-up 18F-fluorodeoxyglucose (18F-FDG) PET/CT scan of a 57-year-old asymptomatic male who had undergone total thyroidectomy for thyroid cancer revealed a 5.0 × 4.0-cm, well-defined, ovoid-shaped mass around the left adrenal gland without definite FDG uptake. On the adrenal CT scan, the left paraadrenal tumor showed high attenuation on the precontrast scan without enhancement. The average Hounsfield unit (HU) was 58.1 on the precontrast scan and 58.4 on the postcontrast scan. The patient underwent laparoscopic adrenalectomy for resection of the left paraadrenal tumor. The final histopathologic exami...
Source: Nuclear Medicine and Molecular Imaging - November 17, 2014 Category: Radiology Source Type: research

Serum thyroglobulin level after radioiodine therapy (Day 3) to predict successful ablation of thyroid remnant in postoperative thyroid cancer
Conclusions High ratioTg (reflecting extensive release of Tg to the blood after RAI therapy) and low stimTg (reflecting small remnant thyroid tissue) constitute the indices of successful ablation after RAI therapy. Immediate Tg level could give an useful information on RAI ablation of postoperative thyroid remnant. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - November 17, 2014 Category: Radiology Source Type: research

Nerve Monitors May Worsen Thyroidectomy OutcomesNerve Monitors May Worsen Thyroidectomy Outcomes
A new nationwide inpatient study suggests that nerve monitors might increase the risk for vocal cord paralysis. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 17, 2014 Category: Consumer Health News Tags: General Surgery News Source Type: news

Robotic versus Endoscopic Thyroidectomy for Thyroid Cancers: A Multi-Institutional Analysis of Early Postoperative Outcomes and Surgical Learning Curves.
Authors: Lee J, Yun JH, Choi UJ, Kang SW, Jeong JJ, Chung WY Abstract Robotic thyroidectomy is an emerging technique with postoperative outcomes that are at least comparable to those of conventional endoscopic thyroidectomy, with some end-points appearing superior. Our multicenter series represents the largest comparison of robotic and endoscopic thyroidectomy to date, with results suggesting a comparable robot technology we used that could overcome some of the technical limitations associated with conventional endoscopic procedures, with reduced operation times and increased lymph node retrieval. Moreover, we foun...
Source: Journal of Oncology - November 17, 2014 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Genetic and clinical features of multiple endocrine neoplasia types 1 and 2.
Authors: Romei C, Pardi E, Cetani F, Elisei R Abstract Multiple endocrine neoplasia (MEN) are clinical inherited syndromes affecting different endocrine glands. Three different patterns of MEN syndromes can occur (MEN 1, MEN 2A, and MEN 2B). MEN syndromes are very rare, affect all ages and both sexes are equally affected. MEN 1 is characterized by the neoplastic transformation of the parathyroid glands, pancreatic islets, anterior pituitary, and gastrointestinal tract. Heterozygous MEN 1 germline mutations have been detected in about 70-80% of patients with MEN 1. The mutations are scattered throughout the entire g...
Source: Journal of Oncology - November 17, 2014 Category: Cancer & Oncology Tags: J Oncol Source Type: research

To treat or not to treat: the role of adjuvant radioiodine therapy in thyroid cancer patients.
Authors: Carballo M, Quiros RM Abstract Radioactive iodine (RAI) is used in treatment of patients with differentiated papillary and follicular thyroid cancer. It is typically used after thyroidectomy, both as a means of imaging to detect residual thyroid tissue or metastatic disease, as well as a means of treatment by ablation if such tissue is found. In this paper, we discuss the indications for and the mechanisms of RAI in the treatment of patients with thyroid cancer. We discuss the attendant risks and benefits that come with its use, as well as techniques used to optimize its effectiveness as an imaging tool an...
Source: Journal of Oncology - November 17, 2014 Category: Cancer & Oncology Tags: J Oncol Source Type: research

New treatment in advanced thyroid cancer.
Authors: Giuffrida D, Prestifilippo A, Scarfia A, Martino D, Marchisotta S Abstract Thyroid cancer is the most common endocrine tumor. Thyroidectomy, radioactive iodine, and TSH suppression represent the standard treatment for differentiated thyroid cancer. Since chemotherapy has been shown to be unsuccessful in case of advanced thyroid carcinomas, the research for new therapies is fundamental. In this paper, we reviewed the recent literature reports (pubmed, medline, EMBASE database, and abstracts published in meeting proceedings) on new treatments in advanced nonmedullary and medullary thyroid carcinomas. Studies...
Source: Journal of Oncology - November 17, 2014 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Minimally-invasive endoscopically-assisted neck dissection for lateral cervical metastases of thyroid papillary carcinoma
We report complete lateral neck dissection and thyroidectomy for papillary thyroid carcinoma using an endoscopically-assisted approach through a small incision, and evaluate its feasibility and safety. Between March 2010 and January 2013, 6 patients with no definite metastases to the lymph nodes at levels II-IV, and 20 with definite metastases to the lymph nodes at levels II-V were selected. Thyroidectomy, dissection of the central compartment (level VI), and ipsilateral level II-IV and II-V neck dissections were done through a small incision in the neck. The steps of endoscopic lateral neck dissection were similar to thos...
Source: British Journal of Oral and Maxillofacial Surgery - November 17, 2014 Category: ENT & OMF Source Type: research

A newly identified missense mutation in RET codon 666 is associated with the development of medullary thyroid carcinoma [Rapid Communication].
Authors: Yamazaki M, Hanamura T, Ito KI, Uchino S, Sakurai A, Komatsu M Abstract A 38-year-old woman with a thyroid nodule measuring approximately 2 cm was suspected to have medullary thyroid carcinoma (MTC) because of markedly elevated serum calcitonin and carcinoembryonic antigen levels. There were no signs of pheochromocytoma, whereas primary hyperparathyroidism was suspected based on the findings of inappropriate hypersecretion of parathyroid hormone although no parathyroid tumor was detected with imaging studies. RET mutation analysis revealed a novel germline missense mutation in codon 666, c.1997A>G (p.K6...
Source: Endocrine Journal - November 16, 2014 Category: Endocrinology Tags: Endocr J Source Type: research

Prognostic classification of thyroid follicular cell tumors using Ki-67 labeling index: Risk stratification of thyroid follicular cell carcinomas [Review].
Authors: Kakudo K, Wakasa T, Ohta Y, Yane K, Ito Y, Yamashita H Abstract This review emphasizes that the so-called high-risk thyroid carcinoma is not a distinct tumor entity, but a group of tumors with different histologies. High-grade histological features, such as tumor necrosis, increased mitoses, and nuclear pleomorphism, together with high Ki-67 labeling index (more than 10%), are good indicators of high-risk thyroid carcinoma and suggest a possible risk for anaplastic transformation. This review proposes the stratification of patients with thyroid carcinoma into low-, moderate-, and high-risk groups based on ...
Source: Endocrine Journal - November 16, 2014 Category: Endocrinology Tags: Endocr J Source Type: research

Surgical management of well-differentiated thyroid carcinoma in children and adolescents: 33 years of experience of a single institution in Serbia.
Authors: Dzodic R, Buta M, Markovic I, Gavrilovic D, Matovic M, Djurisic I, Milovanovic Z, Pupic G, Tasic S, Besic N Abstract Well-differentiated thyroid carcinoma in children and adolescents is rare but demonstrates aggressive behavior. Gross lymph node metastases and distant metastases are common upon first clinical presentation. During a 33-year period (1981-2014) at the Institute of Oncology and Radiology of Serbia, 62 children and adolescents underwent surgery due to well-differentiated thyroid carcinoma. Mean age was 16.7 (range 7-21) years. At the time of diagnosis 6% of patients had lung metastases. Total t...
Source: Endocrine Journal - November 16, 2014 Category: Endocrinology Tags: Endocr J Source Type: research

Static and dynamic prognostic factors of papillary thyroid carcinoma [Review].
Authors: Ito Y, Miyauchi A, Kobayashi K, Kihara M, Miya A Abstract The two types of prognostic factors of papillary thyroid carcinoma (PTC) are static and dynamic. The following static prognostic factors have been conventionally adopted: age, tumor size, extrathyroid extension, lymph node metastasis, and distant metastasis based on pre-, intra- and post-operative findings. These factors are useful to decide therapeutic strategies for PTC patients, including the extent of surgery and radioactive iodine (RAI) ablation. However, even the combination of these factors evaluated pathologically postoperatively is not good...
Source: Endocrine Journal - November 16, 2014 Category: Endocrinology Tags: Endocr J Source Type: research

Changes in serum thyroglobulin antibody levels as a dynamic prognostic factor for early-phase recurrence of thyroglobulin antibody-positive papillary thyroid carcinoma after total thyroidectomy.
Authors: Yamada O, Miyauchi A, Ito Y, Nakayama A, Yabuta T, Masuoka H, Fukushima M, Higashiyama T, Kihara M, Kobayashi K, Miya A Abstract We demonstrated previously that dynamic prognostic markers such as the thyroglobulin (Tg)-doubling time in thyroglobulin antibody (TgAb)-negative papillary thyroid carcinoma (PTC) and changes in pre- and postoperative TgAb levels in TgAb-positive PTC patients more keenly reflect patients' prognosis than conventional static prognostic factors. Here we investigated periodic changes in TgAb levels in 513 TgAb-positive PTC patients who underwent total thyroidectomy. The TgAb levels a...
Source: Endocrine Journal - November 16, 2014 Category: Endocrinology Tags: Endocr J Source Type: research

A case of thyroid storm with a markedly elevated level of circulating soluble interleukin-2 receptor complicated by multiple organ failure and disseminated intravascular coagulation syndrome.
Authors: Shimoda Y, Satoh T, Takahashi H, Katano-Toki A, Ozawa A, Tomaru T, Horiguchi N, Kaira K, Nishioka M, Shibusawa N, Hashimoto K, Wakino S, Mori M, Yamada M Abstract Thyroid storm (TS) is a life-threatening endocrine emergency. However, the pathogenesis of TS is poorly understood. A 40-year-old man was admitted to a nearby hospital with body weight loss and jaundice. Five days after a contrasted abdominal computerized tomography (CT) scan, he exhibited high fever and disturbance of consciousness. He was diagnosed with TS originating from untreated Graves' disease and was transferred to the intensive care unit...
Source: Endocrine Journal - November 16, 2014 Category: Endocrinology Tags: Endocr J Source Type: research

18F-FDG SPECT/CT in the diagnosis of differentiated thyroid carcinoma with elevated thyroglobulin and negative iodine-131 scans.
CONCLUSION: Based on the retrospective analysis of 86 patients, 18F-FDG SPECT/CT has lower sensitivity in the diagnosis of DTC recurrence with elevated Tg and negative iodine-131scan to 18F-FDG PET/CT. The clinical application of FDG SPECT/CT is then limited and cannot replace PET/CT. PMID: 24844253 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - November 15, 2014 Category: Radiology Tags: Q J Nucl Med Mol Imaging Source Type: research

Application of molecular diagnostics to the evaluation of the surgical approach to thyroid cancer.
Authors: Miccoli P Abstract Recent important studies that include long-term follow-up have shown that BRAF and RAS mutations can have negative implications for disease recurrence and survival. BRAF positivity has been shown to be associated with decreased survival and is an independent predictor of poor prognosis. Reliable pre-operative identification of high-risk papillary thyroid cancer (PTC) patients may productively guide initial surgical management since reoperative neck surgery is associated with increased morbidity. However, it is probably too early to conclude that at present it is possible to tailor surgic...
Source: Current Genomics - November 15, 2014 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

TSH Suppression increases the risk of osteoporosis without decreasing recurrence in ATA low and intermediate risk patients with differentiated thyroid carcinoma.
Conclusion TSH suppression significantly increases the risk of postoperative osteoporosis without changing tumor recurrence in ATA low and intermediate risk patients with DTC. Future interventions should focus on avoiding harm in indolent disease. PMID: 25386760 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Reading grade level and completeness of freely available materials on thyroid nodules: There is work to be done.
Conclusions: Existing thyroid nodule evaluation and management materials have serious shortcomings. Future work should focus on the development of patient materials that are both grade level appropriate and meet the DISCERN criteria for topic completeness and accuracy. PMID: 25384093 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Malignant struma ovarii: a population-level analysis of a large series of 68 patients.
Conclusions: We observed that patients with malignant struma ovarii had an excellent disease-specific survival rate, regardless of the management strategy employed. However, MSO patients had a high risk for developing aggressive thyroid cancers. Therefore, MSO patients may benefit from routine thyroid imaging once the diagnosis of MSO is established. PMID: 25375817 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Clinical Management and Outcomes in Patients with Hyperfunctioning Distant Metastases from Differentiated Thyroid Cancer after Total Thyroidectomy and Radioactive Iodine Therapy.
Conclusion: The response of hyperfunctioning lung metastases to 131I treatment was better than that of non-hyperfunctioning lung metastases in DTC, while hyperfunctioning bone metastases responded similarly to non-hyperfunctioning bone metastases. Patients younger than 45 years at occurrence of distant metastases, those with only lung metastases, and patients with PTC had better prognoses. PMID: 25331724 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

A New Strategy to Estimate Levothyroxine Requirement After Total Thyroidectomy for Benign Thyroid Disease.
Conclusions: This study confirms that BW is not the only variable for predicting LT4 requirement, as it decreases with the increase in age and BMI, probably due to the relative decrease of lean body mass. A new correlation between optimal dose and presurgical levels of fT3 and mean corpuscular volume was observed. We propose an easy and more efficient method of calculating LT4 starting dose after total thyroidectomy for benign disease. PMID: 25268754 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Effectiveness of Preventative and Other Surgical Measures on Hypocalcemia Following Bilateral Thyroid Surgery: A Systematic Review and Meta-Analysis.
Conclusion: This review identified postoperative calcium and vitamin D supplementation and bilateral subtotal thyroidectomy (over HD) as being effective in prevention of transient hypocalcemia. However, the majority of RCTs were of low quality, primarily due to a lack of blinding. The wide variability in study design, definitions of hypocalcemia, and methods of assessment prevented meaningful summation of results for permanent hypocalcemia. PMID: 25203484 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Low Serum 25 Hydroxyvitamin D Is Associated with Poor Clinicopathologic Characteristics in Female Patients with Papillary Thyroid Cancer.
Conclusion: Lower preoperative serum 25(OH) vitamin D levels appear to be associated with poor clinicopathologic features in female patients with PTC. PMID: 25133449 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Rebound Thymic Hyperplasia Detected by (18)F-FDG PET/CT After Radioactive Iodine Ablation Therapy for Thyroid Cancer.
Conclusions: RTHP after RIAT showed a strong female predominance, despite the higher administration dose of RAI in male patients. Although the decreased incidence of RTHP after RIAT with age is similar to the pattern of RTHP induced by other causes, the fact that older patients, even sixth decade patients, can present with RTHP after RIAT is noteworthy in the management of DTC. PMID: 25065897 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Noninvasive anaplastic thyroid carcinoma: report of a case and literature review.
We report a case of an 81-year-old man who presented with a 3.1 cm right thyroid lobe mass that on fine-needle aspiration biopsy was diagnosed as an ATC. Preoperative imaging revealed an encapsulated thyroid tumor without evidence of invasion of surrounding structures and no locoregional and distant metastases. A total thyroidectomy was performed that by histologic and immunohistochemical evaluation was diagnostic for a noninvasive ATC. Given the diagnosis of noninvasive ATC, adjuvant therapy was not administered. At 14 months following diagnosis, the patient remains disease free based on positron emission tomography/com...
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

NRAS codon 61 mutation is associated with distant metastasis in patients with follicular thyroid carcinoma.
CONCLUSIONS: The presence of a RAS mutation, especially a NRAS codon 61 mutation, was significantly associated with the distant metastasis. The NRAS codon 61 mutation status might be a potential prognostic factor in FTC patients. PMID: 24820091 [PubMed - in process] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Centralized molecular testing for oncogenic gene mutations complements the local cytopathologic diagnosis of thyroid nodules.
CONCLUSIONS: Centralized and standardized molecular testing for genetic alterations associated with a high risk of malignancy efficiently complements the local cytopathologic diagnosis of thyroid nodule aspirates in the clinical setting. Actionable molecular cytology can improve the personalized surgical and medical management of patients with thyroid cancers, facilitating one-stage total thyroidectomy and reducing the number of unnecessary diagnostic surgeries. PMID: 24811481 [PubMed - in process] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2014 Category: Endocrinology Tags: Thyroid Source Type: research

Surgeon volume and adequacy of thyroidectomy for differentiated thyroid cancer
We aimed to determine influence of surgeon volume on (1) frequency of appropriate initial surgery for differentiated thyroid cancer (DTC) and (2) completeness of resection. (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Authors: Cameron D. Adkisson, Gina M. Howell, Kelly L. McCoy, Michaele J. Armstrong, Meghan L. Kelley, Michael T. Stang, Judith M. Joyce, Steven P. Hodak, Sally E. Carty, Linwah Yip Tags: American Association of Endocrine Surgeons Source Type: research

Comparable outcomes for patients with pT1a and pT1b differentiated thyroid cancer: Is there a need for change in the AJCC classification system?
The current American Joint Committee on Cancer TNM classification for differentiated thyroid cancer (DTC) separates T1 status into T1a and T1b based on a 1-cm cutoff for maximal tumor dimension. In 2009, the American Thyroid Association recommended total thyroidectomy for tumors >1 cm in contrast to the possibility of lobectomy for tumors ≤1 cm. Our aim was to investigate the prognostic significance of a 1-cm tumor cutoff. (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Authors: Laura Y. Wang, Iain J. Nixon, Frank L. Palmer, Dorothy Thomas, R. Michael Tuttle, Ashok R. Shaha, Snehal G. Patel, Jatin P. Shah, Ian Ganly Tags: American Association of Endocrine Surgeons Source Type: research

Discussion
Dr Jacob Moalem (Rochester, NY): I am curious if you looked at the indication for thyroidectomy and if, in the setting of a known thyroid cancer, a patient complaint of hoarseness might be taken differently than in the setting of a benign nodular disease. (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Source Type: research

Discussion
Dr Sareh Parangi (Boston, MA): I see Cord Sturgeon standing there, the senior author of the Billimoria comment, so I probably should let him go first. What I was going to ask about is, in the Billimoria paper, to my understanding, the major issue was total thyroidectomy versus partial thyroidectomy. Did you correct for that or report that? Did I miss it? (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Source Type: research

The utility of lymph node mapping sonogram and thyroglobulin surveillance in post thyroidectomy papillary thyroid cancer patients
The American Thyroid Association recommends lymph node mapping (LNM) ultrasonography 6–12 months after thyroidectomy for patients with papillary thyroid cancer (PTC). The yield of LNM over thyroglobulin (TG) screening is not well defined. We sought to investigate this relationship. (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Authors: Chowdhury F. Miah, Jessica A. Zaman, Mitchell Simon, Tomer Davidov, Stanley Z. Trooskin Tags: American Association of Endocrine Surgeons Source Type: research

The importance of sonographic landmarks by transcutaneous laryngeal ultrasonography in post-thyroidectomy vocal cord assessment
During examination of the vocal cords (VC) using transcutaneous laryngeal ultrasonography (TLUSG), 3 sonographic landmarks (namely, false VC [FC], true VC [TC], and arytenoids [AR]) are often seen. However, it remains unclear which landmark provides a more reliable assessment and whether seeing more landmarks improves the diagnostic accuracy and reliability. (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Authors: Kai-Pun Wong, Jung-Woo Woo, Yeo-Kyu Youn, Felix Che-Lok Chow, Kyu Eun Lee, Brian Hung-Hin Lang Tags: American Association of Endocrine Surgeons Source Type: research

Streamlining variability in hospital charges for standard thyroidectomy: Developing a strategy to decrease waste
We assessed the efficiency, consistency, and appropriateness of perioperative processes for standard (total) thyroidectomy and devised a valuable strategy to decrease variability and waste. (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Authors: Lilah F. Morris, Minerva A. Romero Arenas, Jeffrey Cerny, Joel S. Berger, Connie M. Borror, Meagan Ong, Ashley K. Cayo, Paul H. Graham, Elizabeth G. Grubbs, Jeffrey E. Lee, Nancy D. Perrier Tags: American Association of Endocrine Surgeons Source Type: research

Risk factors for 30-day hospital readmission after thyroidectomy and parathyroidectomy in the United States: An analysis of National Surgical Quality Improvement Program outcomes
The 30-day readmission rate is a quality metric under the Affordable Care Act. Readmission rates after thyroidectomy and parathyroidectomy and associated factors remain ill-defined. We evaluated patient and perioperative factors for association with readmission after thyroidectomy and parathyroidectomy. (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Authors: Matthew G. Mullen, Damien J. LaPar, Sara K. Daniel, Florence E. Turrentine, John B. Hanks, Philip W. Smith Tags: American Association of Endocrine Surgeons Source Type: research

Readmission after thyroidectomy and parathyroidectomy: What can we learn from NSQIP?
Policymakers, clinical leaders, third-party payers, and other key stakeholders are constantly seeking ways to improve the quality of patient care while also decreasing costs. Unplanned and potentially preventable readmissions have been a particular focus of attention as a measure of the quality of health care and as a target for potential cost savings.1,2 From 2003 to 2004, 20% of Medicare beneficiaries (>2 million patients) were rehospitalized within 30 days of discharge, with an estimated cost of $17.5 billion. (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Authors: Tracy S. Wang, Tina W.F. Yen Tags: American Association of Endocrine Surgeons Source Type: research

A novel, ultrarapid parathyroid hormone assay to distinguish parathyroid from nonparathyroid tissue
Frozen section is the gold standard for distinguishing parathyroid tissue from lymph nodes, thyroid nodules, or fat during parathyroidectomy and thyroidectomy. Although a very accurate procedure, it can be time-consuming and costly. We hypothesize that the extremely high concentrations of parathyroid hormone (PTH) in parathyroid tissue allow for modification of a standard PTH assay that would distinguish parathyroid from nonparathyroid tissue in substantially less time than frozen section or any currently available PTH assay. (Source: Surgery)
Source: Surgery - November 13, 2014 Category: Surgery Authors: Benjamin C. James, Sapna Nagar, Miles Tracy, Edwin L. Kaplan, Peter Angelos, Neal H. Scherberg, Raymon H. Grogan Tags: American Association of Endocrine Surgeons Source Type: research