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Abstract: Oesophageal atresia is a congenital malformation that affects approximately 1 in 4000 newborn infants. It is most commonly associated with a distal tracheo-oesophageal fistula. It can also be associated with vertebral anomalies, anorectal malformation, cardiac defects, renal and limb anomalies. It requires surgery, usually within the first day of life to correct the anomaly and establish continuity of the gastrointestinal tract. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - December 1, 2013 Category: Surgery Authors: Gareth P. Hosie, Elizabeth Gavens Tags: Paediatric surgery II Source Type: research
TACRD and VACTERL associations in a fetus: Case report and review of the literature
We report the case of a male fetus with complete agenesis of the trachea and a tracheoesophageal fistula arising from the esophagus that connected through the carina, as well as several abnormalities (congenital cardiac abnormalities, duodenal atresia, vertebral defects, anal atresia, renal defects, limb defects, and diaphragmatic hernia). To our knowledge, few cases of infants with VACTERL or TACRD association have been reported to date. Here, we report a new case of a fetus that showed the full range of VACTERL and TACRD associations. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - December 1, 2013 Category: ENT & OMF Authors: Gan-qiong Xu, Qi-chang Zhou, Ming Zhang, Da-rong Pu, Zhu Ouyang Tags: Case reports Source Type: research
Oesophageal atresia with tracheoesophageal fistula and anal atresia in a patient with a de novo microduplication in 17q12.
We described a patient with a 1.4 Mb duplication at 17q12 detected by SNP-array study and validated using qRT-PCR, who presented with an oesophageal atresia accompanied with tracheoesophageal fistula and anal atresia as well as other symptoms resembling VATER association (thumb hypoplasia, sacral bone defect, cryptorchidism). Genomic rearrangements of chromosome 17q12 are associated with a variety of clinical phenotypes. Only few cases with OA patients with the duplication in 17q12 have been reported. The 17q12 region comprised 15 genes. We propose to consider a role for selected genes such as AATF (cell proliferation and...
Source: European Journal of Medical Genetics - November 12, 2013 Category: Genetics & Stem Cells Authors: Smigiel R, Marcelis C, Patkowski D, de Leeuw N, Bednarczyk D, Barg E, Mascianica K, Maria Sasiadek M, Brunner H Tags: Eur J Med Genet Source Type: research
Treatment of Malignant Tracheoesophageal Fistula
This article addresses the treatment of malignant enterorespiratory fistulas, especially malignant tracheoesophageal fistula (mTEF). mTEF typically occurs after radiochemotherapy for advanced esophageal cancer. Life expectancy is measured in months after successful treatment, and in days to weeks with a persistent fistula. To stop repeated episodes of aspiration and septic pneumonia, single or double stenting of the esophagus and trachea with self-expandable coated stents is the established palliative treatment. The indications, techniques, and pitfalls of esophageal and tracheal stenting are described. Surgical interventi...
Source: Thoracic Surgery Clinics - November 11, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Martin Hürtgen, Sascha C.A. Herber Source Type: research
Esophageal Bypass Operation Prior to Definitive Chemoradiotherapy in Advanced Esophageal Cancer With Tracheobronchial Invasion.
CONCLUSIONS: Esophageal bypass surgery prior to definitive chemoradiotherapy could be performed safely, and this strategy contributed to long-term survival in the patients who achieved a good response to chemoradiotherapy but developed an ERF. PMID: 24200399 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - November 5, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Hihara J, Hamai Y, Emi M, Aoki Y, Taomoto J, Miyata Y, Okada M Tags: Ann Thorac Surg Source Type: research
Second study on the recurrence risk of isolated esophageal atresia with or without trachea‐esophageal fistula among first‐degree relatives: No evidence for increased risk of recurrence of EA/TEF or for malformations of the VATER/VACTERL association spectrum
CONCLUSIONIn contrast to previous studies, our results suggest a very low recurrence risk for isolated EA/TEF and/or for malformations of the VATER/VACTERL association spectrum among first‐degree relatives. Birth Defects Research (Part A), 2013. © 2013 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 1, 2013 Category: Perinatology & Neonatology Authors: Vera Choinitzki, Nadine Zwink, Enrika Bartels, Friederike Baudisch, Thomas M. Boemers, Alice Hölscher, Salmai Turial, Haitham Bachour, Andreas Heydweiller, Ralf Kurz, Peter Bartmann, Markus Pauly, Ulrike Brokmeier, Andreas Leutner, Markus M. Nöthen, Joh Tags: Original Research Article Source Type: research
Mandibulofacial dysostosis (Treacher‐Collins syndrome) in the fetus: Novel association with pectus carinatum in a molecularly confirmed case and review of the fetal phenotype
CONCLUSIONTreacher Collins syndrome can be prenatally detected by ultrasound and should be included in the wide range of genetic syndromes that can be diagnosed at perinatal autopsy. Affected fetuses tend to have a more severe phenotype than living patients. The reported association of Treacher Collins syndrome type 1 with pectus carinatum expands the phenotype, provides information on genotype–phenotype correlation, and suggests possible pathogenetic interactions between neural crest cell disorders and the formation of the sternum that merit investigation. Birth Defects Research (Part A), 2013. © 2013 Wiley Periodicals...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 1, 2013 Category: Perinatology & Neonatology Authors: Anastasia E. Konstantinidou, Iason Tassoulas, Georgios Kallipolitis, Spyros Gasparatos, Voula Velissariou, Helen Paraskevakou Tags: Research Article Source Type: research
A standardised investigative strategy prior to revisional oesophageal surgery in children: High incidence of unexpected findings
Conclusions: This standardised approach for this complex group of patients reveals a high incidence of unexpected anatomical and functional anomalies with significant surgical and possible medico-legal implications. We recommend these investigations during the pre-operative work-up prior to all revisional oesophageal surgery. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - November 1, 2013 Category: Surgery Authors: Nigel J. Hall, Michelle Wyatt, Joe I. Curry, Edward M. Kiely Tags: Original Articles Source Type: research
Indications and outcomes of endoscopic CO2 laser cricopharyngeal myotomy
ConclusionsEndoscopic CO2 laser CPM is a safe treatment for cricopharyngeal dysfunction of various causes, though swallowing outcomes may vary depending on the surgical indication. Early feeding postoperatively after CPM is safe and facilitates early hospital discharge. Level of Evidence4. Laryngoscope, 2013 (Source: The Laryngoscope)
Source: The Laryngoscope - October 29, 2013 Category: ENT & OMF Authors: Jennifer L. Bergeron, Dinesh K. Chhetri Tags: Laryngology Source Type: research
Re: Secondary tracheo‐oesophageal fistula creation without rigid oesophagoscopy
(Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - October 24, 2013 Category: ENT & OMF Authors: A. Harrison, V. Visvanathan, K. Mackenzie Tags: Correspondence: Letters Source Type: research
A case for early bronchoscopic airway assessment after disc battery ingestion
We describe an interesting case of disc battery ingestion with delayed recognition of a TOF. We document the tracheal mucosal healing process of a large airway defect and describe the role of bronchoscopy in guiding the timing of surgical intervention. This case highlights the important role of early bronchoscopic assessment in management of these patients. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - October 7, 2013 Category: Respiratory Medicine Authors: Danielle F. Wurzel, I. Brent Masters, Kelvin L. Choo, Alan F. Isles Tags: Case Report Source Type: research
Concomitant Slide Tracheoplasty and Cardiac Operation for Congenital Tracheal Stenosis Associated With VACTERL.
Abstract The association of congenital tracheal stenosis and tracheoesophageal (TE) fistula is rare. Here, we report 2 patients with tracheobronchial stenosis (complete cartilage ring) involving the lower trachea and right bronchus. Both patients had associated VACTERL (vertebral anomalies, anal atresia, cardiovascular anomalies, TE, renal, and limb defects) congenital cardiac defects and tracheal diverticula after repair of the TE fistula in type C esophageal atresia. The stenotic segment began at the orifice of the TE fistula, which became diverticula after the TE fistula was repaired. Concomitant repair of conge...
Source: The Annals of Thoracic Surgery - October 1, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Wu ET, Wang CC, Lin MT, Huang PM, Chen SJ, Huang CH, Hwang HK, Chen MR, Huang SC Tags: Ann Thorac Surg Source Type: research
041 * surgery in pulmonary tuberculosis
Conclusions: Tuberculosis is essentially a medical disease; surgery comes into play only in special situations. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Santosham, R., Santosham, R. Tags: Non-Oncology I Source Type: research
250 * emergency open surgery for aorto-oesophageal and aorto-tracheal fistula after thoracic endovascular aortic repair: a single-centre experience
Conclusions: AOF and ABF represent severe complications after TEVAR that may occur during mid-term follow-up. Early diagnosis and prompt surgical repair are required to allow for a favourable outcome in these high-risk patients. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Etz, C. D., Luehr, M., Nozdrzykowski, M., Garbade, J., Misfeld, M., Borger, M., Mohr, F. Tags: Infectious aortic complications: Orthotopic full-fix or heterotopic trade-off Source Type: research
Perioperative outcomes of laparoscopic transhiatal esophagectomy with antegrade esophageal inversion for high-grade dysplasia and invasive esophageal cancer
Conclusion: Antegrade LIE is a safe treatment approach for patients with high-grade dysplasia and distal esophageal cancer. Complete resection with an adequate lymph node harvest can be achieved consistently for primary operative resection or after neoadjuvant chemoradiation. (Source: Surgery)
Source: Surgery - September 4, 2013 Category: Surgery Authors: Kyle A. Perry, Luke M. Funk, Peter Muscarella, W. Scott Melvin Tags: Central Surgical Association Source Type: research
Poisson versus logistic regression in a descriptive epidemiologic analysis of data from a Birth Defects Registry
CONCLUSIONFor these descriptive epidemiologic analyses, PR yielded the most precise estimates. However, LR provided similar estimates, and using 10 controls per case yielded precision almost as good as PR. Birth Defects Research (Part A), 2013. © 2013 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 2, 2013 Category: Perinatology & Neonatology Authors: Peter H. Langlois, Mark A. Canfield, Michael D. Swartz Tags: Original Research Article Source Type: research
Using the Pediatric Health Information System to study rare congenital pediatric surgical diseases: Development of a cohort of esophageal atresia patients
Conclusion: Administrative databases such as PHIS can be utilized to identify cohorts of patients with rare congenital anomalies; however, cohort development requires a systematic search strategy and validation process to ensure correct identification of patients. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - September 1, 2013 Category: Surgery Authors: Jason P. Sulkowski, Katherine J. Deans, Lindsey Asti, Peter Mattei, Peter C. Minneci Tags: Original Articles Source Type: research
The role of preoperative CT scan in patients with tracheoesophageal fistula: A review
Conclusion: The usefulness of pre-operative computerized tomography in cases of tracheoesophageal fistula is controversial. The safety of this technique is questionable due to limited facilities and associated radiation hazards. Further, limited information obtained which may help in changing the surgical plan can easily be managed intra-operatively by careful and meticulous surgery.Overall, the safety concerns outweigh its efficacy. Thus, the use of pre-operative CT scan cannot be generalized and protocolized as a standard of care in the management of tracheoesophageal atresia. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - September 1, 2013 Category: Surgery Authors: Saurabh Garge, Rao K.L.N., Monika Bawa Tags: Review Articles Source Type: research
De novo 13q deletions in two patients with mild anorectal malformations as part of VATER/VACTERL and VATER/VACTERL‐like association and analysis of EFNB2 in patients with anorectal malformations
In conclusion, our report underlines the association of chromosome 13q deletions with ARM, suggesting that routine molecular diagnostic workup should include the search for these deletions. Despite the negative results of our mutation screening, we still consider EFNB2 an excellent candidate gene for contributing to the development of ARM in humans. © 2013 Wiley Periodicals, Inc. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - August 16, 2013 Category: Genetics & Stem Cells Authors: Gabriel C. Dworschak, Markus Draaken, Carlo Marcelis, Ivo de Blaauw, Rolph Pfundt, Iris A.L.M. van Rooij, Enrika Bartels, Alina Hilger, Ekkehart Jenetzky, Eberhard Schmiedeke, Sabine Grasshoff‐Derr, Dominik Schmidt, Stefanie Märzheuser, Stuart Hosie, S Tags: Research Article Source Type: research
Simultaneous dual scope endotherapy of esophago‐airway fistulas and obstructions
We present a unique approach for the management of EAF and obstructions with simultaneous upper endoscopy and bronchoscopy (two scopes inserted simultaneously through the mouth). The aim is to assess the efficacy and safety of a simultaneous dual scope approach for management of EAF and obstructions. The endoscopy database at the University of Florida was reviewed from October 2007 to April 2012 to identify adult patients who had undergone simultaneous upper endoscopy and bronchoscopy for EAF and obstructions. Medical records were reviewed for demographics, indication, pathology, imaging, simultaneous endoscopic and bronch...
Source: Diseases of the Esophagus - August 13, 2013 Category: Gastroenterology Authors: A. G. Zori, M. A. Jantz, C. E. Forsmark, M. S. Wagh Tags: Original article Source Type: research
[Unexpected respiratory distress in the delivery room - a rare differential diagnosis for the obstetrician and neonatologist].
We present the case of a female infant born prematurely at 34 weeks of gestation. Prenatally a midsized ventricular septal defect was diagnosed. Due to marked respiratory distress intubation was attempted but failed, since the tube could not be placed beyond the glottis. Oxygenation could be improved by nasopharyngeal bag ventilation. The clinical course as well as radiographic imaging was suggestive for a complete tracheal agenesis with broncho-oesophageal fistula which was confirmed at autopsy. Tracheal agenesis (TA) is a rare differential diagnosis of postnatal respiratory distress and the obstetrician or neonatologist ...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - August 1, 2013 Category: Perinatology & Neonatology Authors: Klotz D, Frölich K, Zollner U, Rehn M, Wirbelauer J Tags: Z Geburtshilfe Neonatol Source Type: research
Comparison of complication rates associated with stapling and traditional suture closure after total laryngectomy for advanced cancer.
Abstract We conducted a retrospective, matched-cohort, case-control study to compare complication rates associated with two wound closure procedures-stapling vs. traditional hand suturing-following total laryngectomy. Our study population was made up of 42 consecutively presenting patients-38 men and 4 women, aged 34 to 92 years (mean: 60.3) whose pharyngotomies were amenable to primary closure. Of this group, 37 patients had active endolaryngeal squamous cell carcinoma (SCC), 2 patients had inactive endolaryngeal SCC, 2 patients had thyroid cancer, and 1 patient had been treated for chronic aspiration. A total of ...
Source: Ear, Nose and Throat Journal - August 1, 2013 Category: ENT & OMF Authors: Miles BA, Larrison D, Myers LL Tags: Ear Nose Throat J Source Type: research
P-195 * experience on the diagnosis and treatment of intrathoracic gastro-airway fistulae after oesophagectomy for oesophageal carcinoma
Conclusions The development of intrathoracic gastro-airway fistulae was associated with the iatrogenic injuries and suturing material irritation of the gastric tube to the tracheal/bronchial wall. Therefore, a meticulous closure and wrapping of gastroplasty and appropriate isolation using artificial patch or great omentum between airway and oesophageal substitution could effectively reduce the fistulae. The stent therapy usually fails in treating this entity and surgical repair remains the final and radical therapeutic option. Primary repair is suggested and careful preoperative assessment remains crucial. Disclosure All ...
Source: Interactive CardioVascular and Thoracic Surgery - July 23, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Chen, L.-Q. Tags: OESOPHAGUS Source Type: research
O-085 * multidisciplinary approach to an unusual airway problem
Conclusions This case demonstrates how this often lethal complication could only be resolved by combining the specific skills of every discipline involved. Disclosure All authors have declared no conflicts of interest. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - July 23, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Van Veer, H., Nafteux, P., Coosemans, W., Vander Poorten, V., Vranckx, J., Neyrinck, A., De Leyn, P. Tags: SESSION XIII: INTERESTING CASES Source Type: research
O-086 * a novel method of tracheo-oesophageal fistula closure
Conclusions Non-cross-linked porcine membrane is an ideal material for infected wound repair. Its consistency and resistance allowed perfect stabilization of the defect. Disclosure All authors have declared no conflicts of interest. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - July 23, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Ampollini, L., Rosi, C., Majori, M., Bilancia, R., Cocconi, A., Rolli, L., Solinas, M., Caliumi, F., Carbognani, P., Rusca, M. Tags: SESSION XIII: INTERESTING CASES Source Type: research
Esophageal Stenting for Treatment of Refractory Benign Esophageal Strictures in Dogs
Conclusions and Clinical ImportanceFindings suggest that esophageal stent placement was safe and technically effective, but unpredictably tolerated in dogs with RBES. If a stent is placed, dogs should be monitored carefully for stent migration, dissolution of absorbable stents, and recurrence of strictures. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - July 19, 2013 Category: Veterinary Research Authors: N. Lam, C. Weisse, A. Berent, J. Kaae, S. Murphy, M. Radlinsky, K. Richter, M. Dunn, K. Gingerich Tags: Original Article Source Type: research
Esophageal atresia in newborns: a wide spectrum from the isolated forms to a full VACTERL phenotype?
Conclusion: The high frequency of non-VACTERL-type anomalies encountered in full and partial phenotype patients would suggest the need for an extension of the clinical criteria for the diagnosis of VACTERL association and also for pre- and post-operative management and follow-up in the short and long term. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - July 10, 2013 Category: Pediatrics Authors: Simona La PlacaMario GiuffrèAntonella GangemiStefania Di NotoFederico MatinaFederica NociforoVincenzo AntonaMaria Di PaceMaria PiccioneGiovanni Corsello Source Type: research
A case series study of therapeutic implications of Type IIIb4: A rare variant of esophageal atresia and distal tracheoesophageal fistula
Conclusions: The knowledge of diagnostic and therapeutic implications of the variant subtype IIIb4 EA-TEF should be in the armamentarium of the treating surgeon to reduce pitfalls in its management. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - July 1, 2013 Category: Surgery Authors: Archana Puri, Partap Singh Yadav, Usha Saha, Ranju Singh, R. Chadha, S. Roy Choudhary Tags: Original Articles Source Type: research
Phase II Study of Percutaneous Transesophageal Gastrotubing for Patients with Malignant Gastrointestinal Obstruction; JIVROSG-0205
Conclusions: PTEG is an effective technique to relieve discomfort in the nasopharynx caused by NGT in patients with terminal malignant tumors. PTEG should be considered an efficacious method for bowel decompression in patients who are ineligible for surgical procedures, percutaneous gastrostomy, or percutaneous enterostomy. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - June 25, 2013 Category: Radiology Authors: Takeshi Aramaki, Yasuaki Arai, Yoshitaka Inaba, Yozo Sato, Hiroya Saito, Miyuki Sone, Yoshito Takeuchi Source Type: research
Pediatric Interventional Bronchoscopy
Pediatric interventional bronchoscopy includes a variety of diagnostic and therapeutic procedures. Restoration of airway patency, management of tracheoesophageal fistula, and difficult airway intubation are just a few pertinent examples. This review discusses the most recently introduced techniques in pediatric bronchology. These interventions include bronchoscopic laser resection, airway stenting, management of central airway stenosis, and the use of ultrathin optical devices. Although no comparative studies are available, the authors compare the different techniques as reported in the literature. Respective advantages an...
Source: Clinics in Chest Medicine - June 19, 2013 Category: Respiratory Medicine Authors: Leonardo L. Donato, Thi Mai Hong Tran, Clement Ammouche, Ali I. Musani Source Type: research
Use of palivizumab in infants and young children with severe respiratory disease: A delphi study
ConclusionA set of indication for off‐label uses of palivizumab in pediatric pulmonology was developed in accordance with the degree of professional consensus on which they were based. The applicability of the present results to clinical practice should be evaluated individually and reviewed periodically in the light of new emerging evidence. Further studies are needed to add evidence to the most frequent and clinically oriented scenarios that have shown higher levels of uncertainty. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - June 17, 2013 Category: Respiratory Medicine Authors: Mirella Gaboli, Òscar Asensio de la Cruz, María Isabel Barrio Gómez de Agüero, Antonio Moreno‐Galdó, Guadalupe Pérez Pérez, Manuel Sánchez‐Solís de Querol Tags: Original Article: Other Source Type: research
Closure of minor tracheoesophageal fistulae with calcium hydroxlapatite
Conclusion: We feel this is an acceptable minimally invasive method to close a persistent pinhole tracheoesophageal fistula after failed management with chemical cautery. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - June 11, 2013 Category: ENT & OMF Authors: Anand V. Kasbekar, Ian W. Sherman Tags: Short Communication Source Type: research
Successful management on a case of dermatomyositis with hydropneumothorax, tracheoesophageal fistula and esophago‐thoracic cavity fistula
(Source: The Journal of Dermatology)
Source: The Journal of Dermatology - June 5, 2013 Category: Dermatology Authors: Jing Gao, Chunjun Yang, Shengxiu Liu, Sen Yang Tags: Letter to the Editor Source Type: research
Tracheal agenesis with broncho-esophageal fistula in VACTERL / TACRD association
We report here autopsy findings in a case of TA with bronchoesophageal fistula of Floyd type III. The other malformations present included laryngeal atresia, Right lung hypolobulation, ventricular septal defect in membranous portion, bilateral cystic renal dysplasia, spleninculus, Meckel's diverticulum, and imperforate anus. The constellations of malformations present in our case have overlapping features with Vertebral anomalies, Anal atresia, Cardiovascular anomalies, Tracheo-esophageal fistula, Esophageal atresia, Renal anomalies, Limb anomalies and Tracheal atresia or laryngo tracheal atresia, Cardiac anomalies,...
Source: Indian Journal of Human Genetics - June 4, 2013 Category: Genetics & Stem Cells Authors: Suresh R. S. MandrekarSangeeta AmoncarR. G. W Pinto Source Type: research
Collaboration in simulation: The development and initial validation of a novel thoracoscopic neonatal simulator
Conclusions: Fellow and faculty ratings indicated the simulator was valuable as a learning tool with minor modifications. Comments were consistent with high physical attribute ratings. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - June 1, 2013 Category: Surgery Authors: Katherine A. Barsness, Deborah M. Rooney, Lauren M. Davis Tags: Papers Presented at the 64th Annual Meeting of the Surgical Section of the American Academy of Pediatrics, New Orleans, LA, October 19-21, 2012 Source Type: research
Esophageal atresia with proximal tracheoesophageal fistula: A missed diagnosis
Abstract: Aim of the Study: This retrospective study was performed to compare the relative incidence of esophageal atresia (EA) with proximal tracheoesophageal fistula (PTEF) at our institution with those reported in literature and to test the hypothesis that our higher relative incidence is caused by the routine use of tracheoscopy.Methods: A total of 204 children with EA were managed at our institution from 1981 to 2012. The type of EA and the diagnostic assessment were noted, and the relative incidence of PTEF was calculated. For patients managed from 1981 to 2003 (Group 1), the PTEF was diagnosed by contrast esophagogr...
Source: Journal of Pediatric Surgery - June 1, 2013 Category: Surgery Authors: Filippo Parolini, Anna Morandi, Francesco Macchini, Lorena Canazza, Maurizio Torricelli, Andrea Zanini, Ernesto Leva Tags: Journal of Pediatric Surgery Electronic Pages (Available only online at www.jpedsurg.org) Source Type: research
Phase 1 Study of Dose Escalation in Hypofractionated Proton Beam Therapy for Non-Small Cell Lung Cancer
Conclusion: Hypofractionated PBT to the thorax delivered over 3 weeks was well tolerated even with significant doses to the lungs and mediastinal structures. Phase 2/3 trials are needed to compare the efficacy of this technique with standard treatment for locally advanced NSCLC. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 20, 2013 Category: Radiology Authors: Daniel R. Gomez, Michael Gillin, Zhongxing Liao, Caimiao Wei, Steven H. Lin, Cameron Swanick, Tina Alvarado, Ritsuko Komaki, James D. Cox, Joe Y. Chang Tags: Thoracic Cancers Source Type: research
Hemorrhagic Pyloroduodenal Duplication Cyst Misdiagnosed as Child Abuse
A 12-month-old boy presented to the emergency department with weight loss and vomiting. His medical history included in utero drug exposure, developmental delay, intrauterine growth restriction, repaired tracheoesophageal fistula, and failure to thrive that worsened before he presented to the emergency department. There was no history of trauma. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 17, 2013 Category: Pediatrics Authors: Kelly Callahan, Steven Lee, Sara Stewart, Carol Berkowitz Tags: Insights and Images Source Type: research
Thoracoscopic repair of esophageal atresia and tracheoesophageal fistula in neonates, first decade's experience
This report evaluates the results and evolution of the technique in a single surgeons' experience after the first decade of thoracoscopic EATEF repair. From March 2000 to September 2012, 52 consecutive patients with type 3 EATEF, and an additional nine patients with pure esophageal atresia (EA) were repaired by or under the direct supervision of a single surgeon. Patient weight ranged from 1.2 to 3.8 kg (mean 2.6 kg). Twenty‐two patients had significant associated congenital anomalies. The repairs were performed using three ports. The fistula was ligated using a single endoscopic clip, and the anastomosis was perform...
Source: Diseases of the Esophagus - May 16, 2013 Category: Gastroenterology Authors: S. S. Rothenberg Tags: Original article Source Type: research
Genetic and cellular mechanisms of the formation of esophageal atresia and tracheoesophageal fistula
Summary Foregut separation involves dynamic changes in the activities of signaling pathways and transcription factors. Recent mouse genetic studies demonstrate that some of these pathways interact with each other to form a complex network, leading to a unique dorsal‐ventral patterning in the early foregut. In this review, it is discussed how this unique dorsal‐ventral patterning is set prior to the foregut separation and how disruption of this patterning affects the separation process. Roles of downstream targets of these pathways in regulating separation at cellular and molecular levels would be discussed further. Und...
Source: Diseases of the Esophagus - May 16, 2013 Category: Gastroenterology Authors: I. J. Jacobs, J. Que Tags: Original article Source Type: research
Epidemiology of esophageal atresia
Summary Esophageal atresia (EA) is a rare congenital malformation consisting of a lack of continuity between the upper and lower esophageal pouches, frequently associated with tracheoesophageal fistula. The prevalence of such rare abnormalities is established by global birth surveillance programs over the world. EUROCAT is a European program covering 1.7 million births since its creation. The prevalence of EA in Europe seems stable over decades. The National Birth Defects Prevention Network in the USA also shows a stable prevalence with a wide range between states or regions. In France, with the implementation of the natio...
Source: Diseases of the Esophagus - May 16, 2013 Category: Gastroenterology Authors: R. Sfeir, L. Michaud, J. Salleron, F. Gottrand Tags: Original article Source Type: research
Diagnosis and surgical management of recurrent tracheoesophageal fistulas
Summary Recurrent tracheoesophageal fistula (TEF) is difficult to diagnose and even more difficult to repair. The key to the diagnosis is an adequate contrast study and bronchoscopy. The key to the repair is complete separation of the esophagus from the trachea, with the placement of viable tissue between the two suture lines. I have presented a personal experience with 38 consecutive repairs of recurrent TEFs. The original series of 26 patients had three recurrences, all of which were re‐repaired successfully. My more recent experience with the last 12 patients, who were far more complex, was also successful in ultimate...
Source: Diseases of the Esophagus - May 16, 2013 Category: Gastroenterology Authors: A. G. Coran Tags: Original article Source Type: research
Anti‐reflux surgery for patients with esophageal atresia
Summary Gastroesophageal reflux (GER) is almost constant in esophageal atresia and tracheoesophageal fistula (EA/TEF). These patients resist medical treatment and require antireflux surgery quite often. The present review examines why this happens, the long‐term consequences of GER and the main indications and results of fundoplication in this particular group of patients. The esophagus of EA/TEF patients is malformed and has abnormal extrinsic and intrinsic innervation and, consequently, deficient sphincter function and dysmotility. These anomalies are permanent. Fifty percent of patients overall have GER, and one‐fif...
Source: Diseases of the Esophagus - May 16, 2013 Category: Gastroenterology Authors: J. A. Tovar, A. C. Fragoso Tags: Original article Source Type: research
Long‐term respiratory complications of congenital esophageal atresia with or without tracheoesophageal fistula: an update
Summary Despite early surgical repair, congenital esophageal atresia with or without tracheoesophageal fistula (EA ± TEF) has long‐term effects on respiratory and gastrointestinal function. This review updates summarizes research published since 2003 on long‐term respiratory complications in patients with a history of EA ± TEF. Pulmonary hypoplasia appears to not be rare in patients with EA ± TEF. Tracheomalacia is common and is associated with respiratory symptoms in childhood. Aspiration, associated with esophageal dysmotility and/or gastroesophageal reflux, may lead to reduced pulmonary function and bronchiectasi...
Source: Diseases of the Esophagus - May 16, 2013 Category: Gastroenterology Authors: T. Kovesi Tags: Original article Source Type: research
Early and late outcome after surgical treatment of acquired non-malignant tracheo-oesophageal fistulae [THORACIC]
CONCLUSIONS Surgical treatment of TOF is associated with good results in terms of control of acute symptoms and long-term outcome, particularly concerning oral intake and spontaneous breathing. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - May 16, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Marulli, G., Loizzi, M., Cardillo, G., Battistella, L., De Palma, A., Ialongo, P., Zampieri, D., Rea, F. Tags: THORACIC Source Type: research
Temporary closure of congenital tracheoesophageal fistula with fogarty catheter
(Source: The Laryngoscope)
Source: The Laryngoscope - May 14, 2013 Category: ENT & OMF Authors: Jae Won Chang, Oak‐Sung Choo, Yoo Seob Shin, Jeong Hong, Chul‐Ho Kim Tags: Pediatrics Source Type: research
Clinical outcomes of tracheoesophageal diversion and laryngotracheal separation in neurologically impaired children
Conclusion: It is suggested that tracheoesophageal diversion and laryngotracheal separation decrease the morbidity of pediatric patients and improve their quality of life and that of their parents. It is suggested that the risk of developing post-operative fistula is higher in pediatric patients with than without pre-operative tracheotomy. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - May 1, 2013 Category: ENT & OMF Authors: Izumi Chida, Koichi Tamura, Shin-ichi Nakagawa, Masahiro Ando, Emi Kuno, Hiroshi Hoshikawa, Nozomu Mori, Noriaki Takeda Tags: Laryngology Source Type: research
Foregut duplication cyst associated with esophageal atresia and tracheoesophageal fistula: A case report and literature review
Abstract: A case of esophageal atresia associated with a foregut duplication cyst is reported and the literature reviewed. This is the first documented occurrence in conjunction with Down syndrome and the second case where both anomalies were treated at the initial surgery. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - May 1, 2013 Category: Surgery Authors: J. Leslie Knod, Aaron P. Garrison, Jason S. Frischer, Belinda Dickie Tags: Journal of Pediatric Surgery Electronic Pages (Available only online at www.jpedsurg.org) Source Type: research
Early developmental outcome following surgery for oesophageal atresia
ConclusionsThis study found a lower than expected developmental score for infants following surgery for OA/TOF in the expressive language subscale compared with the healthy control infants. These findings support concerns over the potential impact of OA/TOF and its effects on development. Further studies, including continuing developmental review to determine whether these differences persist and their functional importance, should be performed. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - April 1, 2013 Category: Pediatrics Authors: Karen Walker, Robert Halliday, Nadia Badawi, Jan Stewart, Andrew JA Holland Tags: Original Article Source Type: research