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Multi-resistant bacteria in spontaneous bacterial peritonitis: A new step in management?
Abstract Spontaneous bacterial peritonitis (SBP) is the most typical infection observed in cirrhosis patients. SBP is responsible for an in-hospital mortality rate of approximately 32%. Recently, pattern changes in the bacterial flora of cirrhosis patients have been observed, and an increase in the prevalence of infections caused by multi-resistant bacteria has been noted. The wide-scale use of quinolones in the prophylaxis of SBP has promoted flora modifications and resulted in the development of bacterial resistance. The efficacy of traditionally recommended therapy has been low in nosocomial infections (up to 40...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: de Mattos AA, Costabeber AM, Lionço LC, Tovo CV Tags: World J Gastroenterol Source Type: research

Managing osteoporosis in ulcerative colitis: Something new?
Abstract The authors revise the latest evidence in the literature regarding managing of osteoporosis in ulcerative colitis (UC), paying particular attention to the latest tendency of the research concerning the management of bone damage in the patient affected by UC. It is wise to assess vitamin D status in ulcerative colitis patients to recognize who is predisposed to low levels of vitamin D, whose deficiency has to be treated with oral or parenteral vitamin D supplementation. An adequate dietary calcium intake or supplementation and physical activity, if possible, should be guaranteed. Osteoporotic risk factors, ...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Piodi LP, Poloni A, Ulivieri FM Tags: World J Gastroenterol Source Type: research

Advances in treatment of ulcerative colitis with herbs: From bench to bedside.
Abstract Ulcerative colitis (UC), an idiopathic inflammatory disorder in the colon, has become a clinical challenge, owing to the increasing incidence and poor prognosis. The conventional treatments for UC including aminosalicylates, corticosteroids, and immunosuppressants, induce remission in only half of patients. Meanwhile, the treatments often come with serious side effects which can be life-threatening. Herbal medicine, one of the most common traditional Chinese medicine modalities, has been introduced for centuries into clinical treatment of many human diseases such as infections and functional disorders. Rec...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Wan P, Chen H, Guo Y, Bai AP Tags: World J Gastroenterol Source Type: research

Irritable bowel syndrome: A microbiome-gut-brain axis disorder?
Abstract Irritable bowel syndrome (IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characteri...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Kennedy PJ, Cryan JF, Dinan TG, Clarke G Tags: World J Gastroenterol Source Type: research

Impact of psychological stress on irritable bowel syndrome.
Abstract Psychological stress is an important factor for the development of irritable bowel syndrome (IBS). More and more clinical and experimental evidence showed that IBS is a combination of irritable bowel and irritable brain. In the present review we discuss the potential role of psychological stress in the pathogenesis of IBS and provide comprehensive approaches in clinical treatment. Evidence from clinical and experimental studies showed that psychological stresses have marked impact on intestinal sensitivity, motility, secretion and permeability, and the underlying mechanism has a close correlation with muco...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Qin HY, Cheng CW, Tang XD, Bian ZX Tags: World J Gastroenterol Source Type: research

Minimally invasive surgery in gastric cancer.
Abstract Minimally invasive surgery for gastric cancer has rapidly gained popularity due to the early detection of early gastric cancer. As advances in instruments and the accumulation of laparoscopic experience increase, laparoscopic techniques are being used for less invasive but highly technical procedures. Recent evidence suggests that the short- and long-term outcomes of minimally invasive surgery for early gastric cancer and advanced gastric cancer are comparable to those of conventional open surgery. However, these results should be confirmed by large-scale multicenter prospective randomized controlled clini...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Son SY, Kim HH Tags: World J Gastroenterol Source Type: research

Hepatitis B and liver transplantation: Molecular and clinical features that influence recurrence and outcome.
We describe some of the more clinically relevant and important genetic variations in the HBV. We also describe current practices at our medical centers, provide a summary and analysis of comparative costs for alternative strategies for prevention of recurrent HBV, and pose important still unanswered questions that are in need of answers during the next decade or two. We conclude that it is now rational and cost-effective to decrease and, perhaps, cease altogether, the routine use of HBIG during and following liver transplantation for HBV infection. Here we propose an individualized prophylaxis regimen, based on an integrat...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Ghaziani T, Sendi H, Shahraz S, Zamor P, Bonkovsky HL Tags: World J Gastroenterol Source Type: research

Immunopathogenesis of chronic hepatitis B.
Abstract Chronic hepatitis B (CHB) is a widespread infectious disease with unfavorable outcomes and life-threatening consequences for patients, in spite of modern vaccination and antiviral treatment modalities. Cutting-edge experimental approaches have demonstrated key pathways that involve cross-talk between viral particles and host immune cells. All events, including penetration of hepatitis B virus (HBV) particles into host cells, establishing persistence, and chronization of CHB infection, and possibility of complete elimination of HBV particles are controlled by the immune system. Researchers have paid special...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Balmasova IP, Yushchuk ND, Mynbaev OA, Alla NR, Malova ES, Shi Z, Gao CL Tags: World J Gastroenterol Source Type: research

Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome.
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. Women with PCOS frequently have metabolic complications including insulin resistance (IR), early diabetes, hypertension and dyslipidemia. Recent studies have demonstrated an association between PCOS and another metabolic complication: nonalcoholic fatty liver disease (NAFLD). NAFLD occurs as a result of abnormal lipid handling by the liver, which sensitizes the liver to injury and inflammation. It can progress to nonalcoholic steatohepatitis (NASH), which is characterized by hepatocyte injury and apoptosis. W...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Kelley CE, Brown AJ, Diehl AM, Setji TL Tags: World J Gastroenterol Source Type: research

Nonalcoholic fatty liver disease and aging: Epidemiology to management.
In conclusion, further epidemiological and pathophysiological insight is warranted. More accurate understanding of the molecular mechanisms of geriatric NAFLD will help in identifying the most appropriate diagnostic and therapeutic approach for individual elderly patients. PMID: 25339806 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Bertolotti M, Lonardo A, Mussi C, Baldelli E, Pellegrini E, Ballestri S, Romagnoli D, Loria P Tags: World J Gastroenterol Source Type: research

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAF...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Paradies G, Paradies V, Ruggiero FM, Petrosillo G Tags: World J Gastroenterol Source Type: research

Non-alcoholic fatty liver disease: What has changed in the treatment since the beginning?
Abstract Non-alcoholic fatty liver disease (NAFLD) is an umbrella term to describe the entire spectrum of this common liver disease. In patients with NAFLD, especially those with non-alcoholic steatohepatitis (NASH), most often have one or more components of the metabolic syndrome, but this is not universal. Although most patients with NAFLD share many clinical features, only a subset of patients develops significant liver inflammation and progressive fibrosis. On the other hand, not all patients with NASH exhibit insulin resistance. NASH can be seen in patients who are lean and have no identifiable risk factors. M...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Baran B, Akyüz F Tags: World J Gastroenterol Source Type: research

Utility of endoscopic ultrasound in patients with portal hypertension.
Abstract Endoscopic ultrasound (EUS) has revolutionized the diagnostic and therapeutic approach to patients with gastrointestinal disorders. Its application in patients with liver disease and portal hypertension is increasing. Patients with chronic liver disease are at risk for development of portal hypertension sequale such as ascites, spontaneous bacterial peritonitis and gastroesophageal varices. Bleeding esophageal and gastric varices are among the most common causes of mortality in patients with cirrhosis. Thus, early detection and treatment improve the outcome in this population. EUS can improve the detection...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Hammoud GM, Ibdah JA Tags: World J Gastroenterol Source Type: research

Improving outcomes in pancreatic cancer: Key points in perioperative management.
Abstract This review focused in the perioperative management of patients with pancreatic cancer in order to improve the outcome of the disease. We consider that the most controversial points in pancreatic cancer management are jaundice management, vascular resection and neo-adjuvant therapy. Preoperative biliary drainage is recommended only in patients with severe jaundice, as it can lead to infectious cholangitis, pancreatitis and delay in resection, which can lead to tumor progression. The development of a phase III clinical trial is mandatory to clarify the role of neo-adjuvant radiochemotherapy in pancreatic ad...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Alamo JM, Marín LM, Suarez G, Bernal C, Serrano J, Barrera L, Gómez MA, Muntané J, Padillo FJ Tags: World J Gastroenterol Source Type: research

Laparoscopic pancreatectomy: Indications and outcomes.
Abstract The application of minimally invasive approaches to pancreatic resection for benign and malignant diseases has been growing in the last two decades. Studies have demonstrated that laparoscopic distal pancreatectomy (LDP) is feasible and safe, and many of them show that compared to open distal pancreatectomy, LDP has decreased blood loss and length of hospital stay, and equivalent post-operative complication rates and short-term oncologic outcomes. LDP is becoming the procedure of choice for benign or small low-grade malignant lesions in the distal pancreas. Minimally invasive pancreaticoduodenectomy (MIPD)...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Liang S, Hameed U, Jayaraman S Tags: World J Gastroenterol Source Type: research

Laparoscopic resection of pancreatic adenocarcinoma: Dream or reality?
Abstract Laparoscopic pancreatic surgery is in its infancy despite initial procedures reported two decades ago. Both laparoscopic distal pancreatectomy (LDP) and laparoscopic pancreaticoduodenectomy (LPD) can be performed competently; however when minimally invasive surgical (MIS) approaches are implemented the indication is often benign or low-grade malignant pathologies. Nonetheless, LDP and LPD afford improved perioperative outcomes, similar to those observed when MIS is utilized for other purposes. This includes decreased blood loss, shorter length of hospital stay, reduced post-operative pain, and expedited ti...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Anderson B, Karmali S Tags: World J Gastroenterol Source Type: research

Alimentary tract duplications in newborns and children: Diagnostic aspects and the role of laparoscopic treatment.
Abstract Alimentary tract duplications are rare congenital lesions normally diagnosed in newborns and children that can occur anywhere from the mouth to the anus and have a reported incidence of approximately 1 in 4500 life births. Symptoms and clinical presentation vary greatly. The presentation varies according to age and location. The treatment finally is surgical; total resection when possible should be the aim of the intervention. In pediatric surgery minimally invasive surgical procedures became more and more important over the last decades. In consequence the operative procedure on alimentary tract duplicati...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Patiño Mayer J, Bettolli M Tags: World J Gastroenterol Source Type: research

Laparoscopic fundoplication for gastroesophageal reflux disease.
Abstract Gastroesophageal reflux disease (GERD) is a condition that develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms and/or complications. Heartburn is the cardinal symptom, often associated with regurgitation. In patients with endoscopy-negative heartburn refractory to proton pump inhibitor (PPI) therapy and when the diagnosis of GERD is in question, direct reflux testing by impedance-pH monitoring is warranted. Laparoscopic fundoplication is the standard surgical treatment for GERD. It is highly effective in curing GERD with a 80% success rate at 20-year follow-up. The...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Frazzoni M, Piccoli M, Conigliaro R, Frazzoni L, Melotti G Tags: World J Gastroenterol Source Type: research

Laparoscopic gastric surgery for cancer: Where do we stand?
Abstract Gastric cancer poses a significant public health problem, especially in the Far East, due to its high incidence in these areas. Surgical treatment and guidelines have been markedly different in the West, but nowadays this debate is apparently coming to an end. Laparoscopic surgery has been employed in the surgical treatment of gastric cancer for two decades now, but with controversies about the extent of resection and lymphadenectomy. Despite these difficulties, the apparent advantages of the laparoscopic approach helped its implementation in early stage and distal gastric cancer, with an increase on the u...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Antonakis PT, Ashrafian H, Isla AM Tags: World J Gastroenterol Source Type: research

Endoscopic ultrasound guided fine needle aspiration and useful ancillary methods.
Abstract The role of endoscopic ultrasound (EUS) in evaluating pancreatic pathology has been well documented from the beginning of its clinical use. High spatial resolution and the close proximity to the evaluated organs within the mediastinum and abdominal cavity allow detection of small focal lesions and precise tissue acquisition from suspected lesions within the reach of this method. Fine needle aspiration (FNA) is considered of additional value to EUS and is performed to obtain tissue diagnosis. Tissue acquisition from suspected lesions for cytological or histological analysis allows, not only the differentiat...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Tadic M, Stoos-Veic T, Kusec R Tags: World J Gastroenterol Source Type: research

Laparoscopic complete mesocolic excision: West meets East.
This article reviews complete mesocolic excision for colon cancer, attempting to identify the risks and benefits of the technique and particularly looking at the reasons why its uptake has not been universal. It also discusses the similarities of a complete mesocolic excision to a colon resection with a D3 lymphadenectomy as well as the role of a laparoscopic approach to this technique. Considering a D3 lymphadenectomy has been the standard of care for stage II and III colon cancers in many of our Asian neighbours for over 20 years, combining this data with data on complete mesocolic excision may provide enough evidence to...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Chow CF, Kim SH Tags: World J Gastroenterol Source Type: research

Advancing frontiers in anaesthesiology with laparoscopy.
Abstract The introduction of laparoscopy in the surgeon's armamentarium was in fact a "revolution in the history of surgery". Since this technique involves insufflation of carbon dioxide it produces several pathophysiological changes which have to be understood by the anaesthesiologist who can modify the anaesthesia technique accordingly. Advantages of laparoscopy include reduced pain, small scars and early return to work. Certain complications specific to laparoscopic surgery are due to carboperitoneum and increased intra-abdominal pressure. Venous air embolism, although very rare, can be lethal if not managed pro...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Sood J Tags: World J Gastroenterol Source Type: research

Gastrointestinal metabolic surgery for the treatment of type 2 diabetes mellitus.
Abstract Medical therapy for type 2 diabetes mellitus is ineffective in the long term due to the progressive nature of the disease, which requires increasing medication doses and polypharmacy. Conversely, bariatric surgery has emerged as a cost-effective strategy for obese diabetic individuals; it has low complication rates and results in durable weight loss, glycemic control and improvements in the quality of life, obesity-related co-morbidity and overall survival. The finding that glucose homeostasis can be achieved with a weight loss-independent mechanism immediately after bariatric surgery, especially gastric b...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Pok EH, Lee WJ Tags: World J Gastroenterol Source Type: research

Therapeutic advances: Single incision laparoscopic hepatopancreatobiliary surgery.
Abstract Single-port laparoscopic surgery (SPLS) is proposed to be a step towards minimizing the invasiveness of surgery, and has since gained popularity in several surgical sub-specialties including hepatopancreatobiliary surgery. SPLS has since been applied to cholecystectomy, liver resection as well as pancreatectomy for a multitude of pathologies. Benefits of SPLS over conventional multi-incision laparoscopic surgery include improved cosmesis and potentially post-operative pain at specific time periods and extra-umbilical sites. However, it is also associated with longer operating time, increased rate of compli...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Chang SK, Lee KY Tags: World J Gastroenterol Source Type: research

Laparoscopic treatment of perforated appendicitis.
This article reviewed the prevalence, approaches, safety disclaimers, perioperative and postoperative outcomes of the laparoscopic appendectomy in the treatment of patients with perforated appendicitis. Special issues including the conversion, interval appendectomy, laparoscopic approach for elderly or obese patient are also discussed to define the role of laparoscopic treatment for patients with perforated appendicitis. PMID: 25339821 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Lin HF, Lai HS, Lai IR Tags: World J Gastroenterol Source Type: research

Role of surgery and transplantation in the treatment of hepatic metastases from neuroendocrine tumor.
This article emphasizes on the role of surgery in the treatment of liver metastases from NET. PMID: 25339822 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Alagusundaramoorthy SS, Gedaly R Tags: World J Gastroenterol Source Type: research

Robotic surgery for rectal cancer: Current immediate clinical and oncological outcomes.
Abstract Laparoscopic rectal surgery continues to be a challenging operation associated to a steep learning curve. Robotic surgical systems have dramatically changed minimally invasive surgery. Three-dimensional, magnified and stable view, articulated instruments, and reduction of physiologic tremors leading to superior dexterity and ergonomics. Therefore, robotic platforms could potentially address limitations of laparoscopic rectal surgery. It was aimed at reviewing current literature on short-term clinical and oncological (pathological) outcomes after robotic rectal cancer surgery in comparison with laparoscopic...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Araujo SE, Seid VE, Klajner S Tags: World J Gastroenterol Source Type: research

Peritoneal carcinomatosis of gastrointestinal tumors: Where are we now?
Abstract The peritoneal stromal tissue which provides a rich source of growth factors and chemokines is a favorable environment for tumor proliferation. The pathophysiological mechanism of peritoneal carcinomatosis is an individual sequence consisting of genetic and environmental factors and remains controversial. The natural history of the disease reveals a poor median prognosis of approximately 6 mo; however aggressive surgery and multimodal treatment options can improve oncologic outcomes. Considering peritoneal carcinomatosis as though it is a locoregional disease but not a metastatic process, cytoreductive sur...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Terzi C, Arslan NC, Canda AE Tags: World J Gastroenterol Source Type: research

Recent advances in the surgical treatment of hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection (LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality i...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Morise Z, Kawabe N, Tomishige H, Nagata H, Kawase J, Arakawa S, Yoshida R, Isetani M Tags: World J Gastroenterol Source Type: research

Predictors of recurrence of Crohn's disease after ileocolectomy: A review.
Abstract Recurrence after ileocolectomy for Crohn's disease (CD) is common and occurs in up to 80% of patients. Such recurrence can result in repeated surgical interventions, an increased need for medical treatment and, frequently, an impaired quality of life. The aim of this overview is to provide a summary of the factors associated with disease recurrence after ileocolectomy for CD. Recurrence can be measured clinically or endoscopically using established scoring systems. Radiology and serologic tests can also be used, oftentimes in conjunction with endoscopy and/or clinical findings. Many patient and operative f...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Connelly TM, Messaris E Tags: World J Gastroenterol Source Type: research

Bloating and functional gastro-intestinal disorders: Where are we and where are we going?
Abstract Bloating is one of the most common and bothersome symptoms complained by a large proportion of patients. This symptom has been described with various definitions, such as sensation of a distended abdomen or an abdominal tension or even excessive gas in the abdomen, although bloating should probably be defined as the feeling (e.g. a subjective sensation) of increased pressure within the abdomen. It is usually associated with functional gastrointestinal disorders, like irritable bowel syndrome, but when bloating is not part of another functional bowel or gastrointestinal disorder it is included as an indepen...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Iovino P, Bucci C, Tremolaterra F, Santonicola A, Chiarioni G Tags: World J Gastroenterol Source Type: research

Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine.
CONCLUSION: Stimulation of MoDCs by B. vulgatus and F. varium may be associated with CRF/UCN1-related intestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. PMID: 25339828 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Koido S, Ohkusa T, Kan S, Takakura K, Saito K, Komita H, Ito Z, Kobayashi H, Takami S, Uchiyama K, Arakawa H, Ito M, Okamoto M, Kajihara M, Homma S, Tajiri H Tags: World J Gastroenterol Source Type: research

FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation.
CONCLUSION: FXR activation attenuates LPS-induced hepatic inflammation in murine NAFLD by reducing expression of proinflammatory cytokines in macrophages. PMID: 25339829 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Yao J, Zhou CS, Ma X, Fu BQ, Tao LS, Chen M, Xu YP Tags: World J Gastroenterol Source Type: research

Effect of intra-arterial infusion with triolein emulsion on rabbit liver.
CONCLUSION: Infusion of triolein emulsion into rabbit livers revealed a minimal transient decrease of liver function, and no specific histopathologic changes. PMID: 25339830 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Kim YW, Park YM, Yoon S, Kim HJ, Park do Y, Cho BM, Choi SH Tags: World J Gastroenterol Source Type: research

Red cell distribution width to platelet ratio: New and promising prognostic marker in acute pancreatitis.
CONCLUSION: We identified RPR as a valuable, novel laboratory test to predict mortality in AP. PMID: 25339831 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Cetinkaya E, Senol K, Saylam B, Tez M Tags: World J Gastroenterol Source Type: research

Liver resection and metabolic disorders: An undescribed mechanism leading to postoperative mortality.
CONCLUSION: As fibrosis was not present or marginal in liver specimens, the real cause of portal hypertension in patients with multiple metabolic disorders should be investigated with further studies. PMID: 25339832 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Zarzavadjian Le Bian A, Costi R, Sbai-Idrissi MS, Smadja C Tags: World J Gastroenterol Source Type: research

Gene expression profile of peripheral blood in colorectal cancer.
CONCLUSION: A novel gene expression profile was associated with CRC and can potentially be applied to blood-based detection assays. PMID: 25339833 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Chang YT, Huang CS, Yao CT, Su SL, Terng HJ, Chou HL, Chou YC, Chen KH, Shih YW, Lu CY, Lai CH, Jian CE, Lin CH, Chen CT, Wu YS, Lin KS, Wetter T, Chang CW, Chu CM Tags: World J Gastroenterol Source Type: research

Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2 frames-per-second?
CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. PMID: 25339834 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Fernandez-Urien I, Carretero C, Borobio E, Borda A, Estevez E, Galter S, Gonzalez-Suarez B, Gonzalez B, Lujan M, Martinez JL, Martínez V, Menchén P, Navajas J, Pons V, Prieto C, Valle J Tags: World J Gastroenterol Source Type: research

Evaluation of "top-down" treatment of early Crohn's disease by double balloon enteroscopy.
CONCLUSION: Top-down treatment with infliximab and azathioprine, as compared with corticosteroid and azathioprine, results in higher rates of earlier deep remission in early CD. PMID: 25339835 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Fan R, Zhong J, Wang ZT, Li SY, Zhou J, Tang YH Tags: World J Gastroenterol Source Type: research

Split-dose vs same-day reduced-volume polyethylene glycol electrolyte lavage solution for morning colonoscopy.
CONCLUSION: Splitting reduced-volume PEG-ELS for morning colonoscopy is as effective as taking the whole dose on the same morning but is better tolerated and preferred by patients. PMID: 25339836 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Chan WK, Azmi N, Mahadeva S, Goh KL Tags: World J Gastroenterol Source Type: research

Treatment of gastric varices with partial splenic embolization in a patient with portal vein thrombosis and a myeloproliferative disorder.
We report a case of a young woman who presented with gastric variceal bleeding secondary to extensive splanchnic venous thrombosis due to a Janus kinase 2 mutation associated myeloproliferative disorder that was managed effectively with partial splenic embolization. PMID: 25339837 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Gianotti R, Charles H, Hymes K, Chandarana H, Sigal S Tags: World J Gastroenterol Source Type: research

Synchronous gallbladder and pancreatic cancer associated with pancreaticobiliary maljunction.
We report the case of a 46-year-old woman who presented with chronic intermittent abdominal pain without jaundice; abdominal ultrasonography showed thickening of the gallbladder wall and dilatation of the bile duct. Endoscopic retrograde cholangiopancreaticography showed pancreatobiliary maljunction with proximal common bile duct dilatation. Pancreatobiliary maljunction was diagnosed. A computed tomography scan of the abdomen showed suspected gallbladder cancer and distal common bile duct obstruction. A pancreatic head mass was incidentally found intraoperative. Radical cholecystectomy with pancreatoduodenectomy was perfor...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Rungsakulkij N, Boonsakan P Tags: World J Gastroenterol Source Type: research

Complete response to sorafenib in a patient with recurrent hepatocellular carcinoma.
Abstract Partial hepatectomy is still the treatment of choice aiming at a cure for patients with hepatocellular carcinoma (HCC), provided that the patient can tolerate the treatment. For patients with multiple recurrent HCC after partial hepatectomy which cannot be treated by re-hepatectomy or local ablative therapy, the prognosis is extremely poor. Sorafenib is a molecular-targeted agent which has been demonstrated in two global phase III randomized controlled trials to show survival benefit for advanced HCC. Here, we present a 56-year-old patient with HCC who showed complete clinical response after sorafenib was ...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Huan HB, Lau WY, Xia F, Ma KS, Bie P Tags: World J Gastroenterol Source Type: research

False esophageal hiatus hernia caused by a foreign body: A fatal event.
This report describes a fatal case of esophageal perforation caused by an unknowingly ingested fishbone, which resulted in lower esophageal necrosis, chest cavity infection, posterior mediastinum fester, and significant upper gastrointestinal accumulation of blood. However, his clinical symptoms and imaging data are very similar with esophageal hiatal hernia. Unfortunately, because the patient was too late in consulting a physician, he finally died of chest infection and hemorrhage caused by thoracic aortic rupture. First, this case report underlines the importance of immediate consultation with a physician as soon as symp...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Lu YP, Yao M, Zhou XY, Huang B, Qi WB, Chen ZH, Xu LS Tags: World J Gastroenterol Source Type: research

AIMS65: A promising upper gastrointestinal bleeding risk score but further validation required.
Abstract A novel upper gastrointestinal bleeding risk stratification score (AIMS65) has recently been developed and validated. It has advantages over existing risk scores including being easy to remember and lack of subjectivity in calculation. We comment on a recent study that has cast doubt on the applicability of AIMS65 in the peptic ulcer disease population. Although promising, further studies are required to evaluate the validity of AIMS65 in various populations. PMID: 25339841 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Boyapati R, Majumdar A, Robertson M Tags: World J Gastroenterol Source Type: research

Medical management of gastric cancer: A 2014 update.
Abstract Gastric cancer represents a serious health problem on a global scale. It is the second leading cause of cancer-related death worldwide. Novel therapeutic targets are desperately needed because the meager improvement in the cure rate of about 10% realized by adjunctive treatments to surgery is unacceptable as > 50% patients with localized gastric cancer succumb to their disease. Either postoperative chemoradiotherapy (United States), pre-and post-operative chemotherapy (Europe), and adjuvant chemotherapy after a D2 resection (Asia) can all be regarded as standards of care in the localized gastric cancer ...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Elimova E, Shiozaki H, Wadhwa R, Sudo K, Chen Q, Estrella JS, Blum MA, Badgwell B, Das P, Song S, Ajani JA Tags: World J Gastroenterol Source Type: research

Proteomic and metabolic prediction of response to therapy in gastric cancer.
Abstract Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer, the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general, but not all patients are responders. The application of targeted therapies and multimodal treatment has improve...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Aichler M, Luber B, Lordick F, Walch A Tags: World J Gastroenterol Source Type: research

MicroRNAs: Promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential.
Abstract Gastric cancer (GC) is the fourth most common cancer worldwide and ranks second in global cancer mortality statistics. Perioperative chemotherapy plays an important role in the management and treatment of advanced stage disease. However, response to chemotherapy varies widely, with some patients presenting no or only minor response to treatment. Hence, chemotherapy resistance is a major clinical problem that impacts on outcome. Unfortunately, to date there are no reliable biomarkers available that predict response to chemotherapy before the start of the treatment, or that allow modification of chemotherapy...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Matuszcak C, Haier J, Hummel R, Lindner K Tags: World J Gastroenterol Source Type: research

Subtotal gastrectomy for gastric cancer.
Abstract Although a steady decline in the incidence and mortality rates of gastric carcinoma has been observed in the last century worldwide, the absolute number of new cases/year is increasing because of the aging of the population. So far, surgical resection with curative intent has been the only treatment providing hope for cure; therefore, gastric cancer surgery has become a specialized field in digestive surgery. Gastrectomy with lymph node (LN) dissection for cancer patients remains a challenging procedure which requires skilled, well-trained surgeons who are very familiar with the fast-evolving oncological p...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Santoro R, Ettorre GM, Santoro E Tags: World J Gastroenterol Source Type: research

Screening for and surveillance of gastric cancer.
Abstract Although the prevalence of gastric cancer (GC) progressively decreased during the last decades, due to improved dietary habit, introduction of food refrigeration and recovered socio-economic level, it still accounts for 10% of the total cancer-related deaths. The best strategy to reduce the mortality for GC is to schedule appropriate screening and surveillance programs, that rises many relevant concerns taking into account its worldwide variability, natural history, diagnostic tools, therapeutic strategies, and cost-effectiveness. Intestinal-type, the most frequent GC histotype, develops through a multiste...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Compare D, Rocco A, Nardone G Tags: World J Gastroenterol Source Type: research