Medicine RSS Search Engine

World Journal of Gastroenterology : WJG World Journal of Gastroenterology : WJG RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the latest items in this publication.

Update on the management of pancreatic cancer: Surgery is not enough.
Abstract Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of death in cancer and has a 5-year survival of < 5%. Only about 15% of the patients present with a resectable PDAC with potential to undergo "curative" surgery. After surgery, local and systemic recurrence, is though very common. The median survival of resected patients with adjuvant chemotherapy after surgery is only 20-23 mo. This underscores the significant need to improve PDAC management strategies. Increased survival rate is dependent on new breakthroughs in our understanding of not at least tumor biology. The aim of this review i...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Ansari D, Gustafsson A, Andersson R Tags: World J Gastroenterol Source Type: research

Perioperative management of distal pancreatectomy.
Abstract Recent advances in surgical techniques and perioperative management have markedly reduced operative morbidity after distal pancreatectomy (DP). However, some questions remain regarding the protocol for the perioperative management of DP, in particular, with regard to the development of pancreatic fistula (PF). A review of DP was therefore conducted in order to standardize the management of patients for a favorable outcome. Overall, operative technique and perioperative management emerged as two critical factors contributing to favorable outcome in DP patients. As for the operative method, surgical and clos...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Fujino Y Tags: World J Gastroenterol Source Type: research

Contra-lateral liver lobe hypertrophy after unilobar Y90 radioembolization: An alternative to portal vein embolization?
Abstract Liver resection (LR) with negative margins confers survival advantage in many patients with hepatic malignancies. However, an adequate future liver remnant (FLR) is imperative for safe LR. Presently, in patients with an inadequate FLR; the 2 most established clinical techniques performed to induce liver hypertrophy are portal vein embolization (PVE) and portal vein ligation. More recently, it has been observed that patients who undergo treatment via Y90 radioembolization experience hypertrophy of the contra-lateral untreated liver lobe. Based on these observations, several investigators have proposed the p...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Teo JY, Goh BK Tags: World J Gastroenterol Source Type: research

Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies.
Abstract Nuclear factor kappa B (NF-κB) has an established role in the regulation of innate immunity and inflammation. NF-κB is also involved in critical mechanisms connecting inflammation and cancer development. Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal, gastric and colorectal cancers. This review will explore NF-κB's function in inflammation-associated gastrointestinal malignancies, highlighting its oncogenic contribution to each step of carcinogenesis. NF-κB's role in the inflammation-to-carcinoma sequence...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Gambhir S, Vyas D, Hollis M, Aekka A, Vyas A Tags: World J Gastroenterol Source Type: research

Updates in vaccination: Recommendations for adult inflammatory bowel disease patients.
Abstract Treatment regimens for inflammatory bowel disease (IBD) incorporate the use of a variety of immunosuppressive agents that increase the risk of infections. Prevention of many of these infections can be achieved by the timely and judicious use of vaccinations. IBD patients tend to be under-immunized. Some of the contributing factors are lack of awareness regarding the significance of vaccinating IBD patients, misperception about safety of vaccinations in immunocompromised patients, ambiguity about the perceived role of the gastroenterologist in contrast to the primary care physician and unavailability of vac...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Chaudrey K, Salvaggio M, Ahmed A, Mahmood S, Ali T Tags: World J Gastroenterol Source Type: research

Hyponatremia in cirrhosis: Pathophysiology and management.
Abstract Hyponatremia is frequently seen in patients with ascites secondary to advanced cirrhosis and portal hypertension. The development of ascites in patients with cirrhosis is multi-factorial. Portal hypertension and the associated systemic vasodilation lead to activation of the sodium-retaining neurohumoral mechanisms which include the renin-angiotensin-aldosterone system, sympathetic nervous system and antidiuretic hormone (ADH). The net effect is the avid retention of sodium and water to compensate for the low effective circulatory volume resulting in the development of ascites. Although not apparent in the ...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: John S, Thuluvath PJ Tags: World J Gastroenterol Source Type: research

Novel CD9-targeted therapies in gastric cancer.
Abstract There are 33 human tetraspanin proteins, emerging as key players in malignancy, the immune system, fertilization, cellular signaling, adhesion, morphology, motility, proliferation, and tumor invasion. CD9, a member of the tetraspanin family, associates with and influences a variety of cell-surface molecules. Through these interactions, CD9 modifies multiple cellular events, including adhesion, migration, proliferation, and survival. CD9 is therefore considered to play a role in several stages during cancer development. Reduced CD9 expression is generally related to venous vessel invasion and metastasis as ...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Murayama Y, Oritani K, Tsutsui S Tags: World J Gastroenterol Source Type: research

Ghrelin-ghrelin O-acyltransferase system in the pathogenesis of nonalcoholic fatty liver disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) is currently considered as the most common liver disease in Western countries, and is rapidly becoming a serious threat to public health worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. The ghrelin-ghrelin O-acyltransferase (GOAT) system has recently been found to play a crucial role in both the development of steatosis and its progression to nonalcoholic steatohepatitis. Ghrelin, the natural ligand of the growth hormone secretagogue receptor, is a 28-amino acid peptide possessing a unique acylation on...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Zhang SR, Fan XM Tags: World J Gastroenterol Source Type: research

Biomarkers in nonalcoholic fatty liver disease-the emperor has no clothes?
Abstract Fatty liver is present in over ten percentage of the world population and it is a growing public health problem. Nonalcoholic fatty liver disease (NAFLD) is not a single disease, but encompasses a spectrum of diseases of different etiologies. It is difficult to find highly specific and sensitive diagnostic biomarkers when a disease is very complex. Therefore, we should aim to find relevant prognostic markers rather than accurate diagnostic markers which will help to minimize the frequency of liver biopsies to evaluate disease progression. There are several biomarker panels commercially available, however, ...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Sanal MG Tags: World J Gastroenterol Source Type: research

Mitochondrial uncoupling protein 2 and pancreatic cancer: A new potential target therapy.
Abstract Overall 5-years survival of pancreatic cancer patients is nearly 5%, making this cancer type one of the most lethal neoplasia. Furthermore, the incidence rate of pancreatic cancer has a growing trend that determines a constant increase in the number of deceases caused by this pathology. The poor prognosis of pancreatic cancer is mainly caused by delayed diagnosis, early metastasis of tumor, and resistance to almost all tested cytotoxic drugs. In this respect, the identification of novel potential targets for new and efficient therapies should be strongly encouraged in order to improve the clinical manageme...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Donadelli M, Dando I, Dalla Pozza E, Palmieri M Tags: World J Gastroenterol Source Type: research

Effects of urotensin-II on cytokines in early acute liver failure in mice.
CONCLUSION: UII plays a role in the pathogenesis and priming of ALF by triggering an inflammatory cascade and driving the early release of cytokines in mice. PMID: 25805930 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Liu LM, Zhao L, Liang DY, Yu FP, Ye CG, Tu WJ, Zhu T Tags: World J Gastroenterol Source Type: research

MicroRNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis.
CONCLUSION: Our findings suggested that miR-1290 may play an oncogenic role in cellular processes of ESCC. PMID: 25805931 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Li M, He XY, Zhang ZM, Li S, Ren LH, Cao RS, Feng YD, Ji YL, Zhao Y, Shi RH Tags: World J Gastroenterol Source Type: research

High-mobility group box 1 expression and lymph node metastasis in intrahepatic cholangiocarcinoma.
CONCLUSION: Our results define an important role of HMGB1 in the progression of cholangiocarcinoma, and HMGB1 may serve as a prognostic marker for IHCC patients. PMID: 25805932 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Xu YF, Ge FJ, Han B, Yang XQ, Su H, Zhao AC, Zhao MH, Yang YB, Yang J Tags: World J Gastroenterol Source Type: research

Hepatitis E in hemodialysis and kidney transplant patients in south-east Italy.
CONCLUSION: This study indicated a higher, but not significant, circulation of HEV in hemodialysis patients vs the healthy population. Chronic hepatitis due to the HEV virus was not observed. PMID: 25805933 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Scotto G, Aucella F, Grandaliano G, Martinelli D, Querques M, Gesuete A, Infante B, Carri PD, Massa S, Salatino G, Bulla F, Fazio V Tags: World J Gastroenterol Source Type: research

Ratio of metastatic lymph nodes is more important for rectal cancer patients treated with preoperative chemoradiotherapy.
CONCLUSION: The LNR is an important prognostic predictor of RFS in rectal cancer patients especially treated with PCRT. Current pN categories could not discriminate between prognostic groups of RFS after PCRT. PMID: 25805934 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Park IJ, Yu CS, Lim SB, Yoon YS, Kim CW, Kim TW, Kim JH, Kim JC Tags: World J Gastroenterol Source Type: research

Real-life outcome of anti-tumor necrosis factor α in the ambulatory treatment of ulcerative colitis.
CONCLUSION: Real-life remission rates of ulcerative colitis under anti-TNFα are overall low, but some patients have a clear long-term benefit. PMID: 25805935 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Baki E, Zwickel P, Zawierucha A, Ehehalt R, Gotthardt D, Stremmel W, Gauss A Tags: World J Gastroenterol Source Type: research

Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virus-infected liver.
CONCLUSION: Decreased expression of hepcidin and ferroportin in SVR patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon plus ribavirin treatment. PMID: 25805936 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Kohjima M, Yoshimoto T, Enjoji M, Fukushima N, Fukuizumi K, Nakamura T, Kurokawa M, Fujimori N, Sasaki Y, Shimonaka Y, Murata Y, Koyama S, Kawabe K, Haraguchi K, Sumida Y, Harada N, Kato M, Kotoh K, Nakamuta M Tags: World J Gastroenterol Source Type: research

Hepatectomy vs radiofrequency ablation for colorectal liver metastasis: A propensity score analysis.
CONCLUSION: Hepatectomy is better than RFA for the treatment of CRLM. However, RFA might be suitable for selected patients with single, small (≤ 2 cm) CRLM. PMID: 25805937 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Lee H, Heo JS, Cho YB, Yun SH, Kim HC, Lee WY, Choi SH, Choi DW Tags: World J Gastroenterol Source Type: research

Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents.
CONCLUSION: Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD. The considerable burden of TB and marked immunosuppression might be attributed to this risk. PMID: 25805938 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Kim ES, Song GA, Cho KB, Park KS, Kim KO, Jang BI, Kim EY, Jeon SW, Lee HS, Yang CH, Lee YK, Lee DW, Kim SK, Kim TO, Lee J, Kim HW, Jee SR, Park SJ, Kim HJ Tags: World J Gastroenterol Source Type: research

High neutrophil-lymphocyte ratio indicates poor prognosis for acute-on-chronic liver failure after liver transplantation.
CONCLUSION: A high NLR is a convenient and available predictor for prognosis of LT patients and can potentially optimize the current criteria for LT in ACLF. PMID: 25805939 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Lin BY, Zhou L, Geng L, Zheng ZY, Jia JJ, Zhang J, Yao J, Zheng SS Tags: World J Gastroenterol Source Type: research

Lack of correlation between Treg quantification assays in inflammatory bowel disease patients.
CONCLUSION: The two methods did not produce equivalent measures of the percentage of total Tregs in the IBD patients studied which is consistent with the conclusion that Tregs subtypes are not equally detected by these two assays. PMID: 25805940 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Brandhorst G, Petrova DT, Weigand S, Eberle C, von Ahsen N, Schmitz J, Schultze FC, Raddatz D, Karaus M, Oellerich M, Walson PD Tags: World J Gastroenterol Source Type: research

Recurrent anal fistulae: Limited surgery supported by stem cells.
CONCLUSION: Stem cells are safe and useful for treating anal fistulae. Healing can be achieved in severe cases, sparing fecal incontinence risk, and improving previous scoring. PMID: 25805941 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Garcia-Olmo D, Guadalajara H, Rubio-Perez I, Herreros MD, de-la-Quintana P, Garcia-Arranz M Tags: World J Gastroenterol Source Type: research

Economic and medical benefits of ultrasound screenings for gallstone disease.
CONCLUSION: Routine screening regime for gallstone disease is both medically and economically valuable. Annual screening for gallstone disease should be recommended. PMID: 25805942 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Shen HJ, Hsu CT, Tung TH Tags: World J Gastroenterol Source Type: research

Weekly pattern of emergency room admissions for peptic ulcers: A population-based study.
CONCLUSION: There is a higher incidence of emergency room admission for PUs on weekends than on weekdays for the total and working populations. PMID: 25805943 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Kao LT, Tsai MC, Lin HC, Pai F, Lee CZ Tags: World J Gastroenterol Source Type: research

Diagnostic value of magnetic resonance cholangiopancreatography in choledocholithiasis.
CONCLUSION: MRCP has high diagnostic accuracy for the detection of choledocholithiasis. MRCP should be the method of choice for suspected cases of CBD stones. PMID: 25805944 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Chen W, Mo JJ, Lin L, Li CQ, Zhang JF Tags: World J Gastroenterol Source Type: research

New therapeutic option for irritable bowel syndrome: Serum-derived bovine immunoglobulin.
Abstract Oral prescription medical foods have long been used in hospital settings but are also appropriate therapies for gastrointestinal disorders in outpatient medical practice. Oral serum-derived bovine immunoglobulin/protein isolate (SBI) has been shown in clinical studies to reduce loose stools and improve stool consistency as well as other symptoms (i.e., abdominal pain, bloating, and urgency) in patients with irritable bowel syndrome with diarrhea (IBS-D) and human immunodeficiency virus-associated enteropathy. This case series reports the outcomes of 14 IBS patients who received SBI as an addition to standa...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Good L, Rosario R, Panas R Tags: World J Gastroenterol Source Type: research

Strongyloidiasis: A case with acute pancreatitis and a literature review.
We present a rare case of acute pancreatitis secondary to Strongyloides. High index of suspicion in patients specifically from endemic countries of origin and lack of other common etiologies of acute pancreatitis may help in early diagnosis and prompt treatment of this potentially fatal infection. PMID: 25805946 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Makker J, Balar B, Niazi M, Daniel M Tags: World J Gastroenterol Source Type: research

Proposed case of mesalazine-induced cardiomyopathy in severe ulcerative colitis.
This report aims to highlight this serious but rare adverse reaction. We report here a case of a young man presenting with cardiogenic shock in the context of recent mesalazine treatment in severe ulcerative colitis. PMID: 25805947 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Fleming K, Ashcroft A, Alexakis C, Tzias D, Groves C, Poullis A Tags: World J Gastroenterol Source Type: research

Colonic sarcoidosis: Unusual onset of a systemic disease.
Abstract Sarcoidosis is a multisystem chronic inflammatory condition of unknown etiology that has the potential to involve every tissue in the body. Sarcoidosis in the gastrointestinal system, and particularly the colon, is very rare. Here, we report the case of a 57-year-old man with no previous diagnosis of sarcoidosis who presented with new onset of abdominal pain and constipation. A colonoscopy revealed that the abdominal pain was caused by an obstructing lesion in the cecum-ascending colon and lacked a clear histologic diagnosis. Radiologic investigation revealed concentric wall thickening of the cecum-ascendi...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Erra P, Crusco S, Nugnes L, Pollio AM, Di Pilla G, Biondi G, Vigliardi G Tags: World J Gastroenterol Source Type: research

Giant gastrointestinal stromal tumour of rare sarcomatoid epithelioid subtype: Case study and literature review.
We report this case and review the literature with a special focus on pathomorphological evaluation, biological aggressiveness and prognostic factors. To our knowledge this is the first report of giant GIST of very uncommon sarcomatoid epithelioid subtype. It is concluded that clinicians should pay attention to the fact that initial diagnosis may be delayed due to mildly asymptomatic and non-specific clinical presentation. Asymptomatic tumours diagnosed at a late stage, which is often the case, can be large on presentation. Prognosis for patients diagnosed with GIST depend on tumour size, mitotic rate, histopathologic subt...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Lech G, Korcz W, Kowalczyk E, Guzel T, Radoch M, Krasnodębski IW Tags: World J Gastroenterol Source Type: research

Bronchial bleeding caused by recurrent pneumonia after radical esophagectomy for esophageal cancer.
Abstract We herein report a case of bronchial bleeding after radical esophagectomy that was treated with lobectomy. A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden hemoptysis. After the esophagectomy, bilateral vocal cord paralysis was observed, and the patient suffered from repeated episodes of aspiration pneumonia. Bronchoscopy revealed hemosputum in the right middle lobe bronchus, and contrast-enhanced computed tomography showed tortuous arteries arising from the right inferior phrenic artery an...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Kitajima T, Momose K, Lee S, Haruta S, Ueno M, Shinohara H, Fujimori S, Fujii T, Takei R, Kohno T, Udagawa H Tags: World J Gastroenterol Source Type: research

Endoscopic ultrasound-guided drainage of postoperative intra-abdominal abscesses.
Abstract Although endoscopic ultrasound (EUS)-guided drainage has become the standard procedure for pancreatic pseudocysts in recent years and is generally regarded as a safe and effective method, there have been few reports of EUS-guided drainage of postoperative intra-abdominal abscesses. Here we report our experience with 4 cases of postoperative intra-abdominal abscesses for which EUS-guided drainage was performed between May 2011 and May 2014. Distal pancreatectomy had been performed in 3 cases, whereas low anterior resection for rectal cancer was performed in the remaining case. All patients underwent transga...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Mandai K, Uno K, Yasuda K Tags: World J Gastroenterol Source Type: research

Pediatric gastric cancer presenting with massive ascites.
We describe the case of a 16-year-old boy presenting with abdominal fullness and poor appetite for 7 d. Sonography showed massive ascites and computed tomography imaging revealed the presence of gastric mucosa thickness with omentum caking. The diagnosis of gastric adenocarcinoma was biopsy-proven endoscopically. Despite gastric adenocarcinoma being quite rare in the pediatric patient population, we should not overlook the possibility of gastric adenocarcinoma when a child presents with distended abdomen and massive ascites. PMID: 25805952 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Lin CH, Lin WC, Lai IH, Wu SF, Wu KH, Chen AC Tags: World J Gastroenterol Source Type: research

Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient.
Abstract The risk of developing hepatocellular carcinoma (HCC) is strongly associated with hepatitis B virus infection. Hepatic angiomyolipoma (AML), a rare benign tumor, is composed of a heterogeneous mixture of adipose cells, smooth muscle cells and blood vessels. Here, we report the case of a 44-year-old man who developed HCC with a concomitant hepatic AML and a cavernous hemangioma, in the absence of cirrhosis. To our knowledge, based on an extensive literature search using the www.pubmed.gov website, this is the first report of an HCC case with both concomitant AML and cavernous hemangioma at the same position...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Ge XW, Zeng HY, Su-Jie A, Du M, Ji Y, Tan YS, Hou YY, Xu JF Tags: World J Gastroenterol Source Type: research

Partial splenectomy using a laparoscopic bipolar radiofrequency device: A case report.
We report a 51-year-old female patient with a solitary lymphangioma located in the upper splenic pole which was managed successfully with laparoscopic partial splenectomy. Surgery lasted 170 min and did not require blood transfusions. The patient recovered well post-operatively and was asymptomatic at the 3-mo follow-up. She had a normal platelet count and no recurrence on ultrasonography or computed tomography. Laparoscopic partial splenectomy is a safe, minimally invasive technique for the treatment of solitary splenic lymphangiomas in the splenic pole. We performed the procedure using the Habib(TM) 4X device. This lapar...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Wang WD, Lin J, Wu ZQ, Liu QB, Ma J, Chen XW Tags: World J Gastroenterol Source Type: research

Congenital left intrahepatic bile duct draining into gastric wall mimicking biliary reflux gastritis.
Abstract Abnormalities and variations of the biliary ducts are not rare. Most aberrant bile ducts eventually drain into the descending part of duodenum through the papilla of vater. However, drainage of the left hepatic bile duct into the stomach is extremely rare. A 29-year old man was admitted to the hospital with the diagnosis of biliary reflux gastritis. Comprehensive imaging modalities were performed including electronic endoscopy, endoscopic ultrasonography, endoscopic retrograde cholangiopancreatography and magnetic resonance cholangio-pancreatography. Finally, congenital ectopic left intrahepatic bile duct ...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Guan J, Zhang L, Chu JP, Lin SC, Li ZP Tags: World J Gastroenterol Source Type: research

Rare case of Helicobacter pylori-positive multiorgan IgG4-related disease and gastric cancer.
Abstract A 61-year-old male from Northeast China presented with a 2-mo history of abdominal distension, pruritus and jaundice. Laboratory testing revealed an elevated serum IgG4 level. A computed tomography scan showed a typical feature of autoimmune pancreatitis (AIP) and cholecystocholangitis. Early gastric cancer was incidentally discovered when endoscopic untrasound-guided fine needle aspiration (EUS-FNA) of the pancreas was carried out. The patient underwent radical subtotal gastrectomy for gastric cancer combined with cholecystectomy. Helicobacter pylori (H. pylori) and IgG4-positive plasmacytes were detected...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Li M, Zhou Q, Yang K, Brigstock DR, Zhang L, Xiu M, Sun L, Gao RP Tags: World J Gastroenterol Source Type: research

Gastrointestinal hemorrhage due to ileal metastasis from primary lung cancer.
We report a patient with small intestinal metastasis from lung squamous cell carcinoma. A 66-year-old man who underwent radical lung cancer surgery was admitted to our hospital. Before starting his fifth cycle of chemotherapy, he was found to have a positive fecal occult blood test. Abdominal computed tomography scan revealed an ileal tumor with mesenteric lymph node enlargement. He underwent laparoscopic resection of the involved small intestine and mesentery. Histopathological analysis confirmed metastasis from lung cancer. We conducted a review of the literature and 64 documented cases of small intestinal metastasis fro...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Liu W, Zhou W, Qi WL, Ma YD, Xu YY Tags: World J Gastroenterol Source Type: research

Icotinib plus gemcitabine for metastatic pancreatic cancer: A case report.
Abstract A large majority of patients diagnosed with pancreatic cancer have advanced metastatic disease with unresectable malignancies. Despite treatment advances, the survival benefit from chemotherapeutic regimens and targeted drugs is limited. Moreover, their application is limited in China because of high toxicity and cost. Recently, inhibitors of epidermal growth factor receptor activity have shown promise for the treatment of solid cancers when used in combination with standard therapy. However, these drugs have not been evaluated extensively for the treatment of pancreatic cancer. Here, we report the treatme...
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Zhao J, Shen H, Hu HG, Huang JJ Tags: World J Gastroenterol Source Type: research

Cobalamin deficiency as an extra intestinal manifestation of Helicobacter pylori infection.
Abstract We read with great interest the excellent review by Wong et al on extra intestinal manifestations of Helicobacter pylori (H. pylori) infection published in the journal. This is a well-documented and structured review. However, I believe that Wong et al failed to report the relationship between H. pylori infection and cobalamin. PMID: 25805959 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Andrès E Tags: World J Gastroenterol Source Type: research

Mesopancreas: A boundless structure, namely the rationale for dissection of the paraaortic area in pancreaticoduodenectomy for pancreatic head carcinoma.
Abstract This review highlights the rationale for dissection of the 16a2 and 16b1 paraaortic area during pancreaticoduodenectomy (PD) for carcinoma of the head of the pancreas. Recent advances in surgical anatomy of the mesopancreas indicate that the retropancreatic area is not a single entity with well defined boundaries but an anatomical site of embryological fusion of peritoneal layers, and that continuity exists between the neuro lymphovascular adipose tissues of the retropancreatic and paraaortic areas. Recent advances in surgical pathology and oncology indicate that, in pancreatic head carcinoma, the mesopanc...
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Peparini N Tags: World J Gastroenterol Source Type: research

Targeted therapy in first line treatment of RAS wild type colorectal cancer.
Abstract The debate on the optimal drug combination for treating chemotherapy-naïve patients with metastatic colorectal cancer has recently become particularly heated. The present editorial will review recent data on this topic. The FIRE-3 and PEAK trials have shown a 7.5 to 12 mo survival advantage with the use anti-epidermal growth factor receptor (anti-EGFR) antibodies. The CALGB 80405 has shown no difference between anti-EGFR and anti-vascular endothelial growth factor agents. All three trials have consistently shown a significant increase in objective response rate. These data suggest that there is a subset o...
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Formica V, Roselli M Tags: World J Gastroenterol Source Type: research

Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: The search for alternative causative factors.
Abstract The incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing. Despite this is apparently associated with the growing increase in obesity, insulin resistance and obesity-related metabolic disturbances their presence is not a necessary or sufficient condition to explain the accumulation of fat in the liver. Conversely, NAFLD is a predictor of other metabolic risks. NAFLD is currently the most frequent chronic liver disease but should not be considered benign or anecdotic because a considerable proportion of patients with NAFLD progress to cirrhosis and end-stage liver di...
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Camps J, Joven J Tags: World J Gastroenterol Source Type: research

To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases.
Abstract Helicobacter pylori (H. pylori) have long been associated with a spectrum of disease outcomes in the gastro-duodenal system. Heterogeneity in bacterial virulence factors or strains is not enough to explain the divergent disease phenotypes manifested by the infection. This review focuses on host genetic factors that are involved during infection and eventually are thought to influence the disease phenotype. We have summarized the different host genes that have been investigated for association studies in H. pylori mediated duodenal ulcer or gastric cancer. We discuss that as the bacteria co-evolved with the...
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Datta De D, Roychoudhury S Tags: World J Gastroenterol Source Type: research

Endoscopic and histologic characteristics of serrated lesions.
Abstract In recent years, a second pathway for colonic carcinogenesis, distinct from the adenomatous pathway, has been explored. This is referred to as serrated pathway and includes three types of polyp, characterised by a serrated appearance of the crypts: hyperplastic polyps (HP), sessile serrated adenomas (SSA) or lesions, and traditional serrated adenomas. Each lesion has its own genetic, as well as macroscopic and microscopic morphological features. Because of their flat aspect, their detection is easier with chromoendoscopy (carmin indigo or narrow-band imaging). However, as we show in this review, the distin...
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B Tags: World J Gastroenterol Source Type: research

Prevalence of human papillomavirus in esophageal carcinoma in Tangshan, China.
CONCLUSION: DNA of high-risk HPV types 16 and 18 is present in esophageal tumors, implicating HPV as a possible etiologic factor for esophageal squamous cell carcinoma. PMID: 25780287 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Mehryar MM, Li SY, Liu HW, Li F, Zhang F, Zhou YB, Zeng Y, Li JT Tags: World J Gastroenterol Source Type: research

Inhibitory effect of TongXie-YaoFang formula on colonic contraction in rats.
CONCLUSION: TXYF formula inhibits colon contraction in rats. This may be related to activation of specific potassium channels and inhibition of extracellular calcium internal flow. PMID: 25780288 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Yang C, Zhang SS, Li XL, Wang ZF, Zhao LQ Tags: World J Gastroenterol Source Type: research

Improved method increases sensitivity for circulating hepatocellular carcinoma cells.
CONCLUSION: Negative depletion enrichment combined with identification using a mixture of antibodies against ASGPR and CPS1 improves sensitivity and specificity for detecting circulating HCC cells. PMID: 25780289 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Liu HY, Qian HH, Zhang XF, Li J, Yang X, Sun B, Ma JY, Chen L, Yin ZF Tags: World J Gastroenterol Source Type: research

Anti-proliferation effects of Twist gene silencing in gastric cancer SGC7901 cells.
CONCLUSION: The Twist gene could serve as a potential molecular target for gene therapy of gastric cancer with targeted small interfering RNA. PMID: 25780290 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Zhang H, Gong J, Kong D, Liu HY Tags: World J Gastroenterol Source Type: research

Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways.
CONCLUSION: HO-1 protects liver against I/R injury by inhibiting TLR2/TLR4-triggered MyD88- and TRIF-dependent signaling pathways and increasing expression of negative regulators of TLR signaling in rats. PMID: 25780291 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Huang HF, Zeng Z, Wang KH, Zhang HY, Wang S, Zhou WX, Wang ZB, Xu WG, Duan J Tags: World J Gastroenterol Source Type: research