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World Journal of Gastroenterology : WJG

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Treatment of peri-anal fistula in Crohn's disease.
Abstract Anal fistulas are a common manifestation of Crohn's disease (CD). The first manifestation of the disease is often in the peri-anal region, which can occur years before a diagnosis, particularly in CD affecting the colon and rectum. The treatment of peri-anal fistulas is difficult and always multidisciplinary. The European guidelines recommend combined surgical and medical treatment with biologic drugs to achieve best results. Several different surgical techniques are currently employed. However, at the moment, none of these techniques appear superior to the others in terms of healing rate. Surgery is alway...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Sica GS, Di Carlo S, Tema G, Montagnese F, Del Vecchio Blanco G, Fiaschetti V, Maggi G, Biancone L Tags: World J Gastroenterol Source Type: research

Surgical treatment of ulcerative colitis: Ileorectal vs ileal pouch-anal anastomosis.
Abstract Total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the current gold standard in the surgical treatment of ulcerative colitis (UC) refractory to medical management. A procedure of significant magnitude carries its own risks including anastomotic failure, pelvic sepsis and a low rate of neoplastic degeneration overtime. Recent studies have shown that total colectomy with ileorectal anastomosis (IRA) has been associated with good long-term functional results in a selected group of UC patients amenable to undergo a strict surveillance for the relatively high risk of cancer in the rectum. This ma...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Scoglio D, Ahmed Ali U, Fichera A Tags: World J Gastroenterol Source Type: research

Crohn's disease and growth deficiency in children and adolescents.
Abstract Nutritional concerns, linear growth deficiency, and delayed puberty are currently detected in up to 85% of patients with Crohn's disease (CD) diagnosed at childhood. To provide advice on how to assess and manage nutritional concerns in these patients, a Medline search was conducted using "pediatric inflammatory bowel disease", "pediatric Crohn's disease", "linear growth", "pubertal growth", "bone health", and "vitamin D" as key words. Clinical trials, systematic reviews, and meta-analyses published between 2008 and 2013 were selected to produce this narrative review. Studies referring to earlier periods we...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Gasparetto M, Guariso G Tags: World J Gastroenterol Source Type: research

Biological therapy for ulcerative colitis: An update.
Abstract Of the diverse biological agents used for patients with ulcerative colitis, the anti-tumor necrosis factor-α agents infliximab and adalimumab have been used in large-scale clinical trials and are currently widely used in the treatment of inflammatory bowel disease patients. Recent studies have indicated that golimumab, oral tofacitinib and vedolizumab reportedly achieved good clinical response and remission rates in ulcerative colitis patients. Thus, we believe that the detailed investigation of various studies on clinical trials may provide important information for the selection of appropriate biologica...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Seo GS, Chae SC Tags: World J Gastroenterol Source Type: research

Enteral stents for the management of malignant colorectal obstruction.
Abstract Colorectal cancer (CRC) is the 3(rd) most common cancer in the United States with more than 10000 new cases diagnosed annually. Approximately 20% of patients with CRC will have distant metastasis at time of diagnosis, making them poor candidates for primary surgical resection. Similarly, 8%-25% of patients with CRC will present with bowel obstruction and will require palliative therapy. Emergent surgical decompression has a high mortality and morbidity, and often leads to a colostomy which impairs the patient's quality of life. In the last decade, there has been an increasing use of colonic stents for pall...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Kaplan J, Strongin A, Adler DG, Siddiqui AA Tags: World J Gastroenterol Source Type: research

Impact of proteolytic enzymes in colorectal cancer development and progression.
Abstract Tumor invasion and metastasis is a highly complicated, multi-step phenomenon. In the complex event of tumor progression, tumor cells interact with basement membrane and extracellular matrix components. Proteolytic enzymes (proteinases) are involved in the degradation of extracellular matrix, but also in cancer invasion and metastasis. The four categories of proteinases (cysteine-, serine-, aspartic-, and metalloproteinases) are named and classified according to the essential catalytic component in their active site. We and others have shown that proteolytic enzymes play a major role not only in colorectal ...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Herszényi L, Barabás L, Hritz I, István G, Tulassay Z Tags: World J Gastroenterol Source Type: research

Probiotics against neoplastic transformation of gastric mucosa: Effects on cell proliferation and polyamine metabolism.
Abstract Gastric cancer is still the second leading cause of cancer death worldwide, accounting for about 10% of newly diagnosed neoplasms. In the last decades, an emerging role has been attributed to the relations between the intestinal microbiota and the onset of both gastrointestinal and non-gastrointestinal neoplasms. Thus, exogenous microbial administration of peculiar bacterial strains (probiotics) has been suggested as having a profound influence on multiple processes associated with a change in cancer risk. The internationally accepted definition of probiotics is live microorganisms that, when administered ...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Russo F, Linsalata M, Orlando A Tags: World J Gastroenterol Source Type: research

Ever-changing endoscopic treatment for early gastric cancer: Yesterday-today-tomorrow.
Abstract Endoscopic resection has been an optimal treatment for selected patients with early gastric cancer (EGC) based on advances in endoscopic instruments and techniques. As endoscopic submucosal dissection (ESD) has been widely used for treatment of EGC along with expanding ESD indication, concerns have been asked to achieve curative resection for EGC while guaranteeing precise prediction of lymph node metastasis (LNM). Recently, new techniques including ESD or endoscopic full-thickness resection combined with sentinel node navigation enable minimal tumor resection and a laparoscopic lymphadenectomy in cases of...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Kim MY, Cho JH, Cho JY Tags: World J Gastroenterol Source Type: research

Short- and long-term outcome of interferon therapy for chronic hepatitis B infection.
Abstract Hepatitis B virus (HBV) infection is a serious clinical problem worldwide. Conventional interferon (IFN)-α has been approved for the treatment of chronic hepatitis B (CHB). Short-term studies have demonstrated that IFN-based therapy is moderately effective in inducing the loss of hepatitis e antigen (HBeAg) or seroconversion (30%-40%) in HBeAg-positive patients and also produces sustained HBV DNA suppression (20%-30%) in HBeAg-negative patients. Many studies have reported a correlation between the HBV genotype and response to IFN treatment. The highest response rate to IFN treatment was found in patients ...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Seo Y, Yano Y Tags: World J Gastroenterol Source Type: research

Update on hepatitis B virus infection.
Abstract Chronic infection with hepatitis B virus (HBV) leads to the development of hepatocellular carcinoma and/or chronic liver failure. Despite extensive research, the immunopathogenesis is not completely understood. Viral persistence and clinical outcomes following HBV infection depend on viral factors and host factors; including genetic factors that determine a host's immune mechanisms. The primary goal of chronic hepatitis B (CHB) treatment is to eradicate HBV or to at least maintain suppression of HBV replication. Despite recent advances in anti-viral agents for chronic HBV infection, complete eradication of...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: You CR, Lee SW, Jang JW, Yoon SK Tags: World J Gastroenterol Source Type: research

Nonalcoholic fatty liver disease and vascular disease: State-of-the-art.
In conclusion, in the presence of NAFLD patients should undergo a complete cardiovascular evaluation to prevent future atherosclerotic complications. Specific life-style modification and aggressive pharmaceutical modification will not only reduce the progression of liver disease, but also reduce morbidity for cardiovascular disease improving overall prognosis and survival. PMID: 25309067 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Fargion S, Porzio M, Fracanzani AL Tags: World J Gastroenterol Source Type: research

Biomarkers for pancreatic cancer: Recent achievements in proteomics and genomics through classical and multivariate statistical methods.
Abstract Pancreatic cancer (PC) is one of the most aggressive and lethal neoplastic diseases. A valid alternative to the usual invasive diagnostic tools would certainly be the determination of biomarkers in peripheral fluids to provide less invasive tools for early diagnosis. Nowadays, biomarkers are generally investigated mainly in peripheral blood and tissues through high-throughput omics techniques comparing control vs pathological samples. The results can be evaluated by two main strategies: (1) classical methods in which the identification of significant biomarkers is accomplished by monovariate statistical te...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Marengo E, Robotti E Tags: World J Gastroenterol Source Type: research

Gene therapy in pancreatic cancer.
This article reviews the basic rationale, gene delivery methods, therapeutic targets and developments of laboratory research and clinical trials in gene therapy of PC by searching the literature published in English using the PubMed database and analyzing clinical trials registered on the Gene Therapy Clinical Trials Worldwide website (http://www. wiley.co.uk/genmed/ clinical). Viral vectors are main gene delivery tools in gene therapy of cancer, and especially, oncolytic virus shows brighter prospect due to its tumor-targeting property. Efficient therapeutic targets for gene therapy include tumor suppressor gene p53, muta...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Liu SX, Xia ZS, Zhong YQ Tags: World J Gastroenterol Source Type: research

Laparoscopic liver resection: Wedge resections to living donor hepatectomy, are we heading in the right direction?
Abstract Despite inception over 15 years ago and over 3000 completed procedures, laparoscopic liver resection has remained mainly in the domain of selected centers and enthusiasts. Requirement of extensive open liver resection (OLR) experience, in-depth understanding of anatomy and considerable laparoscopic technical expertise may have delayed wide application. However healthy scepticism of its actual benefits and presence of a potential publication bias; concern about its safety and technical learning curve, are probably equally responsible. Given that a large proportion of our work, at least in transplantation is...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Cherian PT, Mishra AK, Kumar P, Sachan VK, Bharathan A, Srikanth G, Senadhipan B, Rela MS Tags: World J Gastroenterol Source Type: research

Diagnosis and management of choledocholithiasis in the golden age of imaging, endoscopy and laparoscopy.
Abstract Biliary lithiasis is an endemic condition in both Western and Eastern countries, in some studies affecting 20% of the general population. In up to 20% of cases, gallbladder stones are associated with common bile duct stones (CBDS), which are asymptomatic in up to one half of cases. Despite the wide variety of examinations and techniques available nowadays, two main open issues remain without a clear answer: how to cost-effectively diagnose CBDS and, when they are finally found, how to deal with them. CBDS diagnosis and management has radically changed over the last 30 years, following the dramatic diffusio...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Costi R, Gnocchi A, Di Mario F, Sarli L Tags: World J Gastroenterol Source Type: research

Laparoscopic distal pancreatectomy for adenocarcinoma of the pancreas.
Abstract Since the first report on laparoscopic distal pancreatectomy (LDP) appeared in the 1990s, the procedure has been performed increasingly frequently to treat both benign and malignant lesions of the pancreas. Many earlier publications have shown LDP to be a good alternative to open distal pancreatectomy for benign lesions, although this has never been studied in a prospective, randomized manner. The evidence for the use of LDP to treat adenocarcinoma of the pancreas is not as well established. The purpose of this review is to evaluate the current evidence for LDP in cases of pancreatic adenocarcinoma. We con...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Björnsson B, Sandström P Tags: World J Gastroenterol Source Type: research

Surgical and interventional management of complications caused by acute pancreatitis.
Abstract Acute pancreatitis is one of the most common gastrointestinal disorders worldwide. It requires acute hospitalization, with a reported annual incidence of 13 to 45 cases per 100000 persons. In severe cases there is persistent organ failure and a mortality rate of 15% to 30%, whereas mortality of mild pancreatitis is only 0% to 1%. Treatment principles of necrotizing pancreatitis and the role of surgery are still controversial. Despite surgery being effective for infected pancreatic necrosis, it carries the risk of long-term endocrine and exocrine deficiency and a morbidity and mortality rate of between 10% ...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Karakayali FY Tags: World J Gastroenterol Source Type: research

Development of minimally invasive techniques for management of medically-complicated obesity.
Abstract The field of bariatric surgery has been rapidly growing and evolving over the past several decades. During the period that obesity has become a worldwide epidemic, new interventions have been developed to combat this complex disorder. The development of new laparoscopic and minimally invasive treatments for medically-complicated obesity has made it essential that gastrointestinal physicians obtain a thorough understanding of past developments and possible future directions in bariatrics. New laparoscopic advancements provide patients and practitioners with a variety of options that have an improved safety ...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Rashti F, Gupta E, Ebrahimi S, Shope TR, Koch TR, Gostout CJ Tags: World J Gastroenterol Source Type: research

Stool characteristics of infants receiving short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides: A review.
Abstract Human milk is considered to be the optimal source of infant nutrition. Some of the benefits of breastfeeding have been ascribed to human milk oligosaccharides (HMO). For instance, HMO can affect faecal characteristics such as stool consistency and stool frequency. Such effects on stool characteristics can be beneficial for young infants as hard stools and even constipation is common in that age group. Prebiotics in infant milk formulas have been introduced to exert similar functionalities. A specific mixture of prebiotics consists of a combination of short chain galacto-oligosaccharides and long-chain fruc...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Scholtens PA, Goossens DA, Staiano A Tags: World J Gastroenterol Source Type: research

Interventional treatment for unresectable hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the sixth most common cancer and third leading cause of cancer-related death in the world. The Barcelona clinic liver cancer classification is the current standard classification system for the clinical management of patients with HCC and suggests that patients with intermediate-stage HCC benefit from transcatheter arterial chemoembolization (TACE). Interventional treatments such as TACE, balloon-occluded TACE, drug-eluting bead embolization, radioembolization, and combined therapies including TACE and radiofrequency ablation, continue to evolve, resulting in improved pati...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Murata S, Mine T, Sugihara F, Yasui D, Yamaguchi H, Ueda T, Onozawa S, Kumita SI Tags: World J Gastroenterol Source Type: research

Predictive proteomic biomarkers for inflammatory bowel disease-associated cancer: Where are we now in the era of the next generation proteomics?
Abstract Recent advances in genomic medicine have opened up the possibility of tailored medicine that may eventually replace traditional "one-size-fits all" approaches to the treatment of inflammatory bowel disease (IBD). In addition to exploring the interactions between hosts and microbes, referred to as the microbiome, a variety of strategies that can be tailored to an individual in the coming era of personalized medicine in the treatment of IBD are being investigated. These include prompt genomic screening of patients at risk of developing IBD, the utility of molecular discrimination of IBD subtypes among patien...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Park JM, Han NY, Han YM, Chung MK, Lee HK, Ko KH, Kim EH, Hahm KB Tags: World J Gastroenterol Source Type: research

Complex interactions between microRNAs and hepatitis B/C viruses.
Abstract MicroRNAs (miRNAs) are a class of small noncoding RNAs that post-transcriptionally regulate the expression of many target genes via mRNA degradation or translation inhibition. Many studies have shown that miRNAs are involved in the modulation of gene expression and replication of hepatitis B virus (HBV) and hepatitis C virus (HCV) and play a pivotal role in host-virus interactions. Increasing evidence also demonstrates that viral infection leads to alteration of the miRNA expression profile in hepatic tissues or circulation. The deregulated miRNAs participate in hepatocellular carcinoma (HCC) initiation an...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Fan HX, Tang H Tags: World J Gastroenterol Source Type: research

Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.
Abstract Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually progress to liver inflammation, fibrosis, cirrhosis and even hepatocellular carcinoma. However, the pathogenesis of NAFLD is complex, and no efficient pharmaceutic treatments have yet been established for NAFLD. Accumulating data have shown that the farnesoid X receptor (FXR) plays important roles not only in bile acid metabolism, but also in lipid and carbohydrate homeostasis, inflammatory responses, among others. In this review, we ai...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Xu JY, Li ZP, Zhang L, Ji G Tags: World J Gastroenterol Source Type: research

Pulmonary manifestations of inflammatory bowel disease.
Abstract Extraintestinal manifestations of inflammatory bowel disease (IBD) are a systemic illness that may affect up to half of all patients. Among the extraintestinal manifestations of IBD, those involving the lungs are relatively rare and often overlooked. However, there is a wide array of such manifestations, spanning from airway disease to lung parenchymal disease, thromboembolic disease, pleural disease, enteric-pulmonary fistulas, pulmonary function test abnormalities, and adverse drug reactions. The spectrum of IBD manifestations in the chest is broad, and the manifestations may mimic other diseases. Althou...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Ji XQ, Wang LX, Lu DG Tags: World J Gastroenterol Source Type: research

Review of experimental attempts of islet allotransplantation in rodents: Parameters involved and viability of the procedure.
Abstract The purpose of the present study was to organize the parameters involved in experimental allotransplantation in rodents to elaborate the most suitable model to supply the scarcity of islet donors. We used the PubMed database to systematically search for published articles containing the keywords "rodent islet transplantation" to review. We included studies that involved allotransplantation experiments with rodents' islets, and we reviewed the reference lists from the eligible publications that were retrieved. We excluded articles related to isotransplantation, autotransplantation and xenotransplantation, i...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Iuamoto LR, Meyer A, Chaib E, D'Albuquerque LA Tags: World J Gastroenterol Source Type: research

Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome.
CONCLUSION: A decrease in EGF levels may contribute to the formation of visceral hypersensitivity through downregulation of SERT-mediated 5-HT uptake into enterocytes. PMID: 25309082 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Cui XF, Zhou WM, Yang Y, Zhou J, Li XL, Lin L, Zhang HJ Tags: World J Gastroenterol Source Type: research

Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients.
CONCLUSION: The OHBI frequency is high among 49 Mexican HIV-1+/HBsAg- patients and it was more frequent in patients with detectable HIV RNA, and less frequent in patients who are undergoing HIV-ARV treatment with drugs active against HBV. PMID: 25309083 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Alvarez-Muñoz MT, Maldonado-Rodriguez A, Rojas-Montes O, Torres-Ibarra R, Gutierrez-Escolano F, Vazquez-Rosales G, Gomez A, Muñoz O, Torres J, Lira R Tags: World J Gastroenterol Source Type: research

Revisiting the role of pathological analysis in transarterial chemoembolization-treated hepatocellular carcinoma after transplantation.
CONCLUSION: The histological score allows a reliable stratification of HCC recurrence risk, especially in those recipients found out to be beyond the Milan criteria after orthotopic liver transplantation (OLT). PMID: 25309084 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Vasuri F, Malvi D, Rosini F, Baldin P, Fiorentino M, Paccapelo A, Ercolani G, Pinna AD, Golfieri R, Morselli-Labate AM, Grigioni WF, D'Errico-Grigioni A Tags: World J Gastroenterol Source Type: research

Study of liver cirrhosis over ten consecutive years in Southern China.
CONCLUSION: The major etiology of liver cirrhosis in Southern China is viral hepatitis. However, the proportions of viral hepatitis and HBV are gradually decreasing. Alcoholic LC patients exhibit a greater risk of experiencing UGIB, and HBV LC patients may have a greater risk of HCC. PMID: 25309085 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Wang X, Lin SX, Tao J, Wei XQ, Liu YT, Chen YM, Wu B Tags: World J Gastroenterol Source Type: research

Novel method for esophagojejunal anastomosis after laparoscopic total gastrectomy: Semi-end-to-end anastomosis.
CONCLUSION: The application of semi-end-to-end esophagojejunal anastomosis after LATG is a safe and feasible procedure, which can be easily performed and has a short operation time in terms of anastomosis. PMID: 25309086 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Zhao YL, Su CY, Li TF, Qian F, Luo HX, Yu PW Tags: World J Gastroenterol Source Type: research

Factorial study of moxibustion in treatment of diarrhea-predominant irritable bowel syndrome.
CONCLUSION: An aconite cake-separated moxibustion treatment regimen of 3 treatments/wk and 1 cone/treatment appears to produce better therapeutic effects for D-IBS compared with the other tested regimens. PMID: 25309087 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Zhao JM, Wu LY, Liu HR, Hu HY, Wang JY, Huang RJ, Shi Y, Tao SP, Gao Q, Zhou CL, Qi L, Ma XP, Wu HG Tags: World J Gastroenterol Source Type: research

Novel approach to identifying the hepatitis B virus pre-S deletions associated with hepatocellular carcinoma.
CONCLUSION: CGE is a sensitive approach for HBV pre-S deletion analysis. Pre-S deletion, especially for short DNA fragment deletion, is a useful predictive marker for HCC. PMID: 25309088 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Zhao ZM, Jin Y, Gan Y, Zhu Y, Chen TY, Wang JB, Sun Y, Cao ZG, Qian GS, Tu H Tags: World J Gastroenterol Source Type: research

Clinical characteristics and current management of hepatitis B and C in China.
CONCLUSION: This observational, real-life study has identified some gaps between clinical practice and guideline recommendations in China. To achieve better health outcomes, several improvements, such as disease monitoring and optimizing antiviral regimens, should be made to improve disease management. PMID: 25309089 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Sun YT, Zhang YX, Tang H, Mao Q, Wang XZ, Zhang LY, Chen H, Zhong YN, Lin SM, Zhang DZ Tags: World J Gastroenterol Source Type: research

Gastric emptying evaluation by ultrasound prior colonoscopy: An easy tool following bowel preparation.
CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia. PMID: 25309090 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Coriat R, Polin V, Oudjit A, Henri F, Dhooge M, Leblanc S, Delchambre C, Esch A, Tabouret T, Barret M, Prat F, Chaussade S Tags: World J Gastroenterol Source Type: research

Laparoscopic liver resection for malignancy: A review of the literature.
CONCLUSION: In the hands of experienced surgeons, laparoscopic liver resection for malignant lesions is safe and offers some short-term advantages over open resection. Oncologically, similar survival rates have been observed in patients treated with the laparoscopic approach when compared to their open resection counterparts. PMID: 25309091 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Alkhalili E, Berber E Tags: World J Gastroenterol Source Type: research

Problem of living liver donation in the absence of deceased liver transplantation program: Mansoura experience.
This report focuses on the analysis of causes, duration, cost, and various implications of donor exclusion (n = 792). Most of the transplant candidates (82.3%) had an experience with more than one excluded donor (median = 3). Some recipients travelled abroad for a deceased donor transplant (n = 12) and some died before finding a suitable donor (n = 14). The evaluation of an excluded donor is a time-consuming process (median = 3 d, range 1 d to 47 d). It is also a costly process with a median cost of approximately 70 USD (range 35 USD to 885 USD). From these results, living donor exclusion has negative implications on the p...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Wahab MA, Hamed H, Salah T, Elsarraf W, Elshobary M, Sultan AM, Shehta A, Fathy O, Ezzat H, Yassen A, Elmorshedi M, Elsaadany M, Shiha U Tags: World J Gastroenterol Source Type: research

Meckel's diverticulum incarcerated in a transmesocolic internal hernia.
Abstract Intestinal obstruction is a common complication associated with Meckel's diverticulum in adults. The diverticulum itself or its fibrous band can lead to an intestinal volvulus, intussusceptions, or closed-loop obstructions, which require surgery. The incarceration of Meckel's diverticulum in either inguinal or femoral hernia sacs (Littre's hernia) is another, less common, etiology underlying intestinal obstruction. This case report describes a 45-year-old man who had an obstruction associated with a Meckel's diverticulum that passed through a congenital defect in the mesocolon into the right subphrenic spa...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Wu SY, Ho MH, Hsu SD Tags: World J Gastroenterol Source Type: research

Active gastrointestinal diverticulum bleeding diagnosed by computed tomography angiography.
We report one case of massive jejunal diverticula bleeding and one case of massive colonic diverticula bleeding, both diagnosed by acute abdominal computed tomography angiography and treated successfully by surgery. PMID: 25309094 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Xu XQ, Hong T, Li BL, Liu W Tags: World J Gastroenterol Source Type: research

Intra-abdominal inflammatory myofibroblastic tumor: Spontaneous regression.
Abstract Inflammatory myofibroblastic tumors are usually treated by surgical resection. We herein report two cases of intra-abdominal inflammatory myofibroblastic tumors that were unresectable and underwent spontaneous regression without any treatment. Our case report and literature review show that regression is more common in the middle-aged and older male populations. Abdominal discomfort and fever were the most common symptoms, but the majority of patients had no obvious physical signs. There was no specific indicator for diagnosis. The majority of the lesions regressed within 3 mo and nearly all of the masses ...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Zhao JJ, Ling JQ, Fang Y, Gao XD, Shu P, Shen KT, Qin J, Sun YH, Qin XY Tags: World J Gastroenterol Source Type: research

Long-term survival after enucleation of a giant esophageal gastrointestinal stromal tumor.
We report a 29-year-old male was admitted after the detection of a posterior mediastinal mass during work-up with routine examination. He did not have any disease-related symptoms. The physical examination was unremarkable. Chest computed tomographic scan, the barium esophagogram and endoscopic esophageal ultrasound showed benign neoplasm. The patient was performed an enucleation surgery through the right posterolateral thoracotomy. The pathology revealed a 13.0 cm × 12.0 cm × 5.0 cm mass. The tumor was CD117 (C-kit), PDGFRA and DOG1 positive. These findings were consistent with a GIST of the esophagus. So the diagnosis ...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Mu ZM, Xie YC, Peng XX, Zhang H, Hui G, Wu H, Liu JX, Chen BK, Wu D, Ye YW Tags: World J Gastroenterol Source Type: research

Contribution of TLR signaling to the pathogenesis of colitis-associated cancer in inflammatory bowel disease.
Abstract In the intestine a balance between proinflammatory and repair signals of the immune system is essential for the maintenance of intestinal homeostasis. The innate immunity ensures a primary host response to microbial invasion, which induces an inflammatory process to localize the infection and prevent systemic dissemination of pathogens. The key elements of this process are the germline encoded pattern recognition receptors including Toll-like receptors (TLRs). If pathogens cannot be eliminated, they may elicit chronic inflammation, which may be partly mediated via TLRs. Additionally, chronic inflammation h...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Sipos F, Fűri I, Constantinovits M, Tulassay Z, Műzes G Tags: World J Gastroenterol Source Type: research

Eligibility of persons who inject drugs for treatment of hepatitis C virus infection.
Abstract In this decade, an increase is expected in end-stage liver disease and hepatocellular carcinoma, most commonly caused by hepatitis C virus (HCV) infection. Although people who inject drugs (PWID) are the major source for HCV infection, they were excluded from antiviral treatments until recently. Nowadays there is incontrovertible evidence in favor of treating these patients, and substitution therapy and active substance use are no longer contraindications for antiviral treatment. The viral clearance in PWID after HCV antiviral treatment with interferon or pegylated interferon combined with ribavirin is com...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Arain A, Robaeys G Tags: World J Gastroenterol Source Type: research

Potential for human immunodeficiency virus parenteral transmission in the Middle East and North Africa: An analysis using hepatitis C virus as a proxy biomarker.
Abstract The Middle East and North Africa (MENA) region has endured several major events of infection parenteral transmission. Recent work has established the utility of using hepatitis C virus (HCV) as a proxy biomarker for assessing the epidemic potential for human immunodeficiency virus (HIV) parenteral transmission. In this review, we use data on the prevalence of HCV infection antibody (seroprevalence) among general population and high risk population groups to assess the potential for HIV parenteral transmission in MENA. Relatively low prevalence of HCV infection in the general population groups was reported ...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Mohamoud YA, Miller FD, Abu-Raddad LJ Tags: World J Gastroenterol Source Type: research

Immune evasion strategies used by Helicobacter pylori.
Abstract Helicobacter pylori (H. pylori) is perhaps the most ubiquitous and successful human pathogen, since it colonizes the stomach of more than half of humankind. Infection with this bacterium is commonly acquired during childhood. Once infected, people carry the bacteria for decades or even for life, if not treated. Persistent infection with this pathogen causes gastritis, peptic ulcer disease and is also strongly associated with the development of gastric cancer. Despite induction of innate and adaptive immune responses in the infected individual, the host is unable to clear the bacteria. One widely accepted h...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Lina TT, Alzahrani S, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE Tags: World J Gastroenterol Source Type: research

Effect of Helicobacter pylori on gastric epithelial cells.
Abstract The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori (H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori's avoidance of this initial line of ho...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Alzahrani S, Lina TT, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE Tags: World J Gastroenterol Source Type: research

Beyond the stomach: An updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment.
Abstract Helicobacter pylori (H. pylori) is an extremely common, yet underappreciated, pathogen that is able to alter host physiology and subvert the host immune response, allowing it to persist for the life of the host. H. pylori is the primary cause of peptic ulcers and gastric cancer. In the United States, the annual cost associated with peptic ulcer disease is estimated to be $6 billion and gastric cancer kills over 700000 people per year globally. The prevalence of H. pylori infection remains high (> 50%) in much of the world, although the infection rates are dropping in some developed nations. The drop in ...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Testerman TL, Morris J Tags: World J Gastroenterol Source Type: research

Role of Helicobacter pylori infection on nutrition and metabolism.
Abstract Helicobacter pylori (H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interest...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Franceschi F, Annalisa T, Teresa DR, Giovanna D, Ianiro G, Franco S, Viviana G, Valentina T, Riccardo LL, Antonio G Tags: World J Gastroenterol Source Type: research

Hematologic manifestations of Helicobacter pylori infection.
Abstract Helicobacter pylori (H. pylori) is the most common infection in humans, with a marked disparity between developed and developing countries. Although H. pylori infections are asymptomatic in most infected individuals, they are intimately related to malignant gastric conditions such as gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma and to benign diseases such as gastritis and duodenal and gastric peptic ulcers. Since it was learned that bacteria could colonize the gastric mucosa, there have been reports in the medical literature of over 50 extragastric manifestations involving a...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Campuzano-Maya G Tags: World J Gastroenterol Source Type: research

Role of Helicobacter pylori infection in autoimmune systemic rheumatic diseases.
Abstract The relationship between infection and autoimmunity has been increasingly defined over the last 20 years. The systemic rheumatic diseases are characterized by dysregulation of the immune system resulting in a loss of tolerance to self-antigen. The exact etiology for the majority of these diseases is unknown; however, a complex combination of host and environmental factors are believed to play a pivotal role. Helicobacter pylori (H. pylori) is one of the most widely studied infectious agents proposed as agents triggering autoimmune response. The persistent presence of H. pylori in the gastric mucosa results...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Radić M Tags: World J Gastroenterol Source Type: research

Diagnosis of Helicobacter pylori: What should be the gold standard?
Abstract Since the discovery of Helicobacter pylori (H. pylori) in 1983, numerous detection methods for the presence of the bacterium have been developed. Each one of them has been associated with advantages and disadvantages. Noninvasive tests such as serology, (13)C urea breath test (UBT) and stool antigen tests are usually preferred by the clinicians. Serology has its own limitation especially in endemic areas while (13)C UBT is technically very demanding. The stool antigen detection method, although specific, is usually associated with poor sensitivity. The (13)C UBT is believed to be specific, but with present...
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G Tags: World J Gastroenterol Source Type: research