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World Journal of Gastroenterology : WJG

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Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21(st) century.
We describe approaches for improving the results of enzyme therapy including changing to, or adding, a different product, adding non-enteric coated enzymes, (e.g., giving unprotected enzymes at the start of the meal and acid-protected formulations later), use of antisecretory drugs and/or antacids, and changing the timing of enzyme administration. Because considerable lipid is emptied in the first postprandial hour, it is prudent to start therapy with enteric coated microbead prior to the meal so that some enzymes are available during that first hour. Patients with hyperacidity may benefit from adjuvant antisecretory thera...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Trang T, Chan J, Graham DY Tags: World J Gastroenterol Source Type: research

Small bowel adenocarcinoma and Crohn's disease: Any further ahead than 50 years ago?
Abstract This review of the literature on small bowel carcinoma associated with Crohn's disease specifically addresses the incidence, risk factors, and protective factors which have been identified. It also reviews the clinical presentation, the current modalities of diagnosis, the pathology, treatment, and surveillance. Finally, the prognosis and future direction are addressed. Our experience with small bowel adenocarcinoma in Crohn's disease is reported. Readers will be provided with a better understanding of this rare and often poorly recognized complication of Crohn's disease. PMID: 25206256 [PubMed - as su...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Cahill C, Gordon PH, Petrucci A, Boutros M Tags: World J Gastroenterol Source Type: research

Ulcerative colitis: From inflammation to cancer. Do estrogen receptors have a role?
Abstract Ulcerative colitis (UC) is a condition at increased risk for colorectal carcinoma (CRC) development. Nowadays, screening and follow-up programs are routinely performed worldwide to promote the early detection of CRCs in subjects with well known risk factors (extent, duration and severity of the disorder). The diffusion of these procedures is presumably the main reason for the marked reduction of cancer incidence and mortality in the course of UC. In addition, chemoprevention has been widely investigated and developed in many medical fields, and aspirin has shown a preventive effect against CRC, while mesal...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Principi M, Barone M, Pricci M, De Tullio N, Losurdo G, Ierardi E, Di Leo A Tags: World J Gastroenterol Source Type: research

Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease.
Abstract It has been presumed that aberrant immune response to intestinal microorganisms in genetically predisposed individuals may play a major role in the pathogenesis of the inflammatory bowel disease, and there is a good deal of evidence supporting this hypothesis. Commensal enteric bacteria probably play a central role in pathogenesis, providing continuous antigenic stimulation that causes chronic intestinal injury. A strong biologic rationale supports the use of probiotics and prebiotics for inflammatory bowel disease therapy. Many probiotic strains exhibit anti-inflammatory properties through their effects o...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Orel R, Kamhi Trop T Tags: World J Gastroenterol Source Type: research

Clinical characteristics and treatment of inflammatory bowel disease: A comparison of Eastern and Western perspectives.
Abstract Inflammatory bowel disease (IBD) is a chronic, relapsing intestinal inflammatory disorder with unidentified causes. Both environmental factors and genetic aspects are believed to be crucial to the pathogenesis of IBD. The incidence and prevalence of IBD have recently been increasing throughout Asia, presumably secondary to environmental changes. This increasing trend in IBD epidemiology necessitates specific health care planning and education in Asia. To this end, we must gain a precise understanding of the distinctive clinical and therapeutic characteristics of Asian patients with IBD. The phenotypes of I...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Park SJ, Kim WH, Cheon JH Tags: World J Gastroenterol Source Type: research

Transanal endoscopic surgery in rectal cancer.
Abstract Total mesorectal excision (TME) is the standard treatment for rectal cancer, but complications are frequent and rates of morbidity, mortality and genitourinary alterations are high. Transanal endoscopic microsurgery (TEM) allows preservation of the anal sphincters and, via its vision system through a rectoscope, allows access to rectal tumors located as far as 20 cm from the anal verge. The capacity of local surgery to cure rectal cancer depends on the risk of lymph node invasion. This means that correct preoperative staging of the rectal tumor is necessary. Currently, local surgery is indicated for rectal...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Serra-Aracil X, Mora-Lopez L, Alcantara-Moral M, Caro-Tarrago A, Gomez-Diaz CJ, Navarro-Soto S Tags: World J Gastroenterol Source Type: research

Racial and ethnic disparities in gastric cancer outcomes: More important than surgical technique?
Abstract Racial and ethnic disparities in cancer care are major public health concerns and their identification is necessary to develop interventions to eliminate these disparities. We and others have previously observed marked disparities in gastric cancer outcomes between Eastern and Western patients. These disparities have long been attributed to surgical technique and extent of lymphadenectomy. However, more recent evidence suggests that other factors such as tumor biology, environmental factors such as Helicobacter pylori infection and stage migration may also significantly contribute to these observed dispari...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Merchant SJ, Li L, Kim J Tags: World J Gastroenterol Source Type: research

Metachronous gastric cancer after successful Helicobacter pylori eradication.
Abstract The high incidence of gastric cancer in Japan initially resulted in establishment of a country-wide gastric cancer screening program to detect early and treatable cancers. In 2013 countrywide Helicobacter pylori (H. pylori) eradication was approved coupled with endoscopy to assess for the presence of chronic gastritis. Current data support the notion that cure of the infection in those with non-atrophic gastritis will prevent development of gastric cancer. However, while progression to more severe damage is halted in those who have already developed, atrophic gastritis/gastric atrophy remain at risk for su...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Shiotani A, Haruma K, Graham DY Tags: World J Gastroenterol Source Type: research

Cellular physiological approach for treatment of gastric cancer.
Abstract Recent studies show that ion channels/transporters play important roles in fundamental cellular functions that would be involved in the cancer process. We review the evidence for their expression and functioning in human gastric cancer (GC), and evaluate the potential of cellular physiological approach in clinical management. Various types of ion channels, such as voltage-gated K(+) channels, intracellular Cl(-) channels and transient receptor potential channels have been found to express in GC cells and tissues, and to control cell cycles. With regard to water channels, aquaporin 3 and 5 play an important...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Shiozaki A, Ichikawa D, Otsuji E, Marunaka Y Tags: World J Gastroenterol Source Type: research

What make differences in the outcome of adjuvant treatments for resected gastric cancer?
Abstract After a long history of Dark Age of adjuvant chemotherapy for gastric cancer, definite evidences of survival benefit from adjuvant treatment have been reported since 2000s. These survival benefits are likely attributed to something new approach different from pervious studies. In 2001, South West Oncology Group INT0116 trial yielded survival benefit in curatively resected gastric cancer patients with postoperative chemoradiotherapy [5-fluorouracil (5-FU) + Leucovorin + radiotherapy], followed by positive result by MAGIC Trial, employing peri-operative(pre- and postoperative chemotherapy with Epirubicin, ci...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Nakajima T, Fujii M Tags: World J Gastroenterol Source Type: research

Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications.
Abstract Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully conside...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Pinheiro DD, Ferreira WA, Barros MB, Araújo MD, Rodrigues-Antunes S, Borges BD Tags: World J Gastroenterol Source Type: research

Towards personalized perioperative treatment for advanced gastric cancer.
Abstract Gastric cancer is one of the most frequently diagnosed cancers worldwide. Although the rate of gastric cancer has declined dramatically over the past decades in most developed Western countries, it has not declined in East Asia. Currently, a radical gastrectomy is still the only curative treatment for gastric cancer. Over the last twenty years, however, surgery alone has been replaced by a multimodal perioperative approach. To achieve the maximum benefit from the perioperative treatment, a thorough evaluation of the tumor must first be performed. A complete assessment of gastric cancer is divided into two ...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Miao RL, Wu AW Tags: World J Gastroenterol Source Type: research

Chronic hepatitis B in 2014: Great therapeutic progress, large diagnostic deficit.
Abstract This review analyzes progress and limitations of diagnosis, screening, and therapy of patients with chronic hepatitis B infection. A literature review was carried out by framing the study questions. Vaccination in early childhood has been introduced in most countries and reduces the infection rate. Treatment of chronic hepatitis B can control viral replication in most patients today. It reduces risks for progression and may reverse liver fibrosis. The treatment effect on development of hepatocellular carcinoma is less pronounced when cirrhosis is already present. Despite the success of vaccination and ther...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Niederau C Tags: World J Gastroenterol Source Type: research

Control of hepatitis B virus replication by interferons and Toll-like receptor signaling pathways.
Abstract Hepatitis B virus (HBV) infection is one of the major causes of liver diseases, affecting more than 350 million people worldwide. The interferon (IFN)-mediated innate immune responses could restrict HBV replication at the different steps of viral life cycle. Indeed, IFN-α has been successfully used for treatment of patients with chronic hepatitis B. However, the role of the innate immune response in HBV replication and the mechanism of the anti-HBV effect of IFN-α are not completely explored. In this review, we summarized the currently available knowledge about the IFN-mediated anti-HBV effect in the HBV...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Pei RJ, Chen XW, Lu MJ Tags: World J Gastroenterol Source Type: research

Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis.
Abstract Hepatitis B virus (HBV) infection is a global public health problem with approximately 2 billion people that have been exposed to the virus. HBV is a member of a family of small, enveloped DNA viruses called hepadnaviruses, and has a preferential tropism for hepatocytes of mammals and birds. Epidemiological studies have proved a strong correlation between chronic hepatitis B virus infection and the development of hepatocellular carcinoma (HCC). HCC is the fifth most common malignancy with about 700000 new cases each year, and more than 50% of them arise in HBV carriers. A large number of studies describe t...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Tarocchi M, Polvani S, Marroncini G, Galli A Tags: World J Gastroenterol Source Type: research

Management of antiviral drug resistance in chronic hepatitis B.
Abstract Rescue antiviral treatment for patients with resistance to preexisting nucleos(t)ide analogues remains a clinical challenge. The correct choice of a first-line treatment of high potency and with a high genetic barrier to achieve sustained long-term suppression of viral replication provides the best chance of preventing treatment failure and the emergence of drug resistance. The management of treatment failure and drug resistance requires a precise and accurate clinical and virologic monitoring. Combination treatment with antiviral drugs that belong to different groups is associated with a lower chance of d...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Bang KB, Kim HJ Tags: World J Gastroenterol Source Type: research

Phage display creates innovative applications to combat hepatitis B virus.
This article reviews critically and comprehensively the innovative and potential applications of phage display in the development of vaccines, therapeutic agents, diagnostic reagents, as well as gene and drug delivery systems to combat HBV. The application of phage display in epitope mapping of HBV antigens is also discussed in detail. Although this review mainly focuses on HBV, the innovative applications of phage display could also be extended to other infectious diseases. PMID: 25206271 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Tan WS, Ho KL Tags: World J Gastroenterol Source Type: research

Bacteriophages and their applications in the diagnosis and treatment of hepatitis B virus infection.
Abstract Hepatitis B virus (HBV) infection is a major global health challenge leading to serious disorders such as cirrhosis and hepatocellular carcinoma. Currently, there exist various diagnostic and therapeutic approaches for HBV infection. However, prevalence and hazardous effects of chronic viral infection heighten the need to develop novel methodologies for the detection and treatment of this infection. Bacteriophages, viruses that specifically infect bacterial cells, with a long-established tradition in molecular biology and biotechnology have recently been introduced as novel tools for the prevention, diagno...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Bakhshinejad B, Sadeghizadeh M Tags: World J Gastroenterol Source Type: research

Diagnosis of alcoholic liver disease.
Abstract Alcohol is a hepatotoxin that is commonly consumed worldwide and is associated with a spectrum of liver injury including simple steatosis or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic liver disease (ALD) is a general term used to refer to this spectrum of alcohol-related liver injuries. Excessive or harmful alcohol use is ranked as one of the top five risk factors for death and disability globally and results in 2.5 million deaths and 69.4 million annual disability adjusted life years. All patients who present with clinical features of hepatitis or chronic liver disease or who hav...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Torruellas C, French SW, Medici V Tags: World J Gastroenterol Source Type: research

Advances in the management of peritoneal mesothelioma.
Abstract Malignant peritoneal mesothelioma (PM) is an infrequent disease which has historically been associated with a poor prognosis. Given its long latency period and non-specific symptomatology, a diagnosis of PM can be suggested by occupational exposure history, but ultimately relies heavily on imaging and diagnostic biopsy. Early treatment options including palliative operative debulking, intraperitoneal chemotherapy, and systemic chemotherapy have marginally improved the natural course of the disease with median survival being approximately one year. The advent of cytoreduction (CRS) with hyperthermic intrape...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Raza A, Huang WC, Takabe K Tags: World J Gastroenterol Source Type: research

Bovine immunoglobulin protein isolates for the nutritional management of enteropathy.
Abstract The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus (HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable ...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Petschow BW, Blikslager AT, Weaver EM, Campbell JM, Polo J, Shaw AL, Burnett BP, Klein GL, Rhoads JM Tags: World J Gastroenterol Source Type: research

MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer.
Abstract Colorectal cancer (CRC) is the third most common cancer in western countries. Despite significant improvement in available treatment options, CRC still remains the second leading cause of cancer-related death. Traditionally, 5-fluorouracil has been used as the main chemotherapy drug for treatment of metastatic CRC (mCRC). However, during the last two decades more effective chemotherapeutic agents such as oxaliplatin, irinotecan and the monoclonal antibodies cetuximab, panitumumab and bevacizumab have been used in clinical practice. More recently, the therapeutic armamentarium has been supplemented by the m...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Stiegelbauer V, Perakis S, Deutsch A, Ling H, Gerger A, Pichler M Tags: World J Gastroenterol Source Type: research

Impact of Clostridium difficile infection on inflammatory bowel disease outcome: A review.
Abstract Although a considerable number of studies support a substantial increase in incidence, severity, and healthcare costs for Clostridium difficile infection (CDI) in inflammatory bowel disease (IBD), only few evaluate its impact on IBD outcome. Medline and several other electronic databases from January 1993 to October 2013 were searched in order to identify potentially relevant literature. Most of the studies showed that IBD patients with CDI present a greater proportion of worse outcomes than those without CDI. These patients have longer length of hospital stay, higher rates of colectomies, and increased mo...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Trifan A, Stanciu C, Stoica O, Girleanu I, Cojocariu C Tags: World J Gastroenterol Source Type: research

Impacts of common factors of life style on serum liver enzymes.
CONCLUSION: Life-style associated changes in liver enzymes may reflect health risks, which should be considered in the definition of normal limits for liver enzymes. PMID: 25206278 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Danielsson J, Kangastupa P, Laatikainen T, Aalto M, Niemelä O Tags: World J Gastroenterol Source Type: research

Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance.
CONCLUSION: Osthol treatment attenuated liver steatosis by decreasing de novo liver triglyceride synthesis and had nominal effects on insulin resistance and liver inflammation. PMID: 25206279 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Nam HH, Jun DW, Jeon HJ, Lee JS, Saeed WK, Kim EK Tags: World J Gastroenterol Source Type: research

Comparison of Abbott and Da-an real-time PCR for quantitating serum HBV DNA.
CONCLUSION: The Da-an assay presented lower sensitivity and a narrower linear range as compared to the Abbott assay, suggesting the need to be improved. PMID: 25206280 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Qiu N, Li R, Yu JG, Yang W, Zhang W, An Y, Li T, Liu XE, Zhuang H Tags: World J Gastroenterol Source Type: research

Connexin 32 and 43 promoter methylation in Helicobacter pylori-associated gastric tumorigenesis.
CONCLUSION: Cx32 and Cx43 mRNA expression decreased gradually during H. pylori infection-associated gastric carcinogenesis, and it is associated with hypermethylation of these genes' promoter. PMID: 25206281 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Wang Y, Huang LH, Xu CX, Xiao J, Zhou L, Cao D, Liu XM, Qi Y Tags: World J Gastroenterol Source Type: research

Characterization of monocarboxylate transporter activity in hepatocellular carcinoma.
CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. PMID: 25206282 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Alves VA, Pinheiro C, Morais-Santos F, Felipe-Silva A, Longatto-Filho A, Baltazar F Tags: World J Gastroenterol Source Type: research

PRSS1 and SPINK1 mutations in idiopathic chronic and recurrent acute pancreatitis.
CONCLUSION: Two novel PRSS1 mutations and one novel SPINK1 mutation were identified in Mexican patients with early onset idiopathic recurrent acute pancreatitis. PMID: 25206283 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Pelaez-Luna M, Robles-Diaz G, Canizales-Quinteros S, Tusié-Luna MT Tags: World J Gastroenterol Source Type: research

Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients.
CONCLUSION: MCP-1 GG genotype and G allele may predispose HCV infected patients to a more progressive disease course, while AG genotype may increase the susceptibility to SBP. Patients carrying these genotypes should be under supervision to prevent or restrict further complications. PMID: 25206284 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Salama MK, Sabry D, Al-Ghussein MA, Ahmed R, AbdAllah S, Taha FM, Fathy W, Wadie MS, Nabih M, Abul-Fotouh A, Darwish T Tags: World J Gastroenterol Source Type: research

Clinical presentations of gastric small gastrointestinal stromal tumors mimics functional dyspepsia symptoms.
CONCLUSION: Symptoms of gastric small GISTs may mimic those of functional dyspepsia. An alternative diagnosis should be considered in patients with functional dyspepsia and treatment failure. PMID: 25206285 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Yu QX, He ZK, Wang J, Sun C, Zhao W, Wang BM Tags: World J Gastroenterol Source Type: research

Impact of medical therapy on patients with Crohn's disease requiring surgical resection.
CONCLUSION: Significant changes in patient phenotypes and medication exposures were observed between the two surgical cohorts separated by a decade. PMID: 25206286 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Fu YN, Hong T, Round A, Bressler B Tags: World J Gastroenterol Source Type: research

Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests.
CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. PMID: 25206287 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Felipo V, Urios A, Giménez-Garzó C, Cauli O, Andrés-Costa MJ, González O, Serra MA, Sánchez-González J, Aliaga R, Giner-Durán R, Belloch V, Montoliu C Tags: World J Gastroenterol Source Type: research

Surgical failure after colonic stenting as a bridge to surgery.
CONCLUSION: The use of multiple self-expanding metal stents appears to be a risk factor for surgical failure. PMID: 25206288 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Kim JH, Kwon KA, Lee JJ, Lee WS, Baek JH, Kim YJ, Chung JW, Kim KO, Park DK, Kim JH Tags: World J Gastroenterol Source Type: research

Parallel transjugular intrahepatic portosystemic shunt for controlling portal hypertension complications in cirrhotic patients.
CONCLUSION: Parallel TIPS is an effective approach for controlling portal hypertension complications. PMID: 25206289 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: He FL, Wang L, Yue ZD, Zhao HW, Liu FQ Tags: World J Gastroenterol Source Type: research

Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester.
CONCLUSION: These differentiated proteins in colorectal cancer cells following CAPE treatment, may be potential molecular targets of CAPE and involved in the anti-cancer effect of CAPE. PMID: 25206290 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: He YJ, Li WL, Liu BH, Dong H, Mou ZR, Wu YZ Tags: World J Gastroenterol Source Type: research

Radiologic-pathologic correlation of three-dimensional shear-wave elastographic findings in assessing the liver ablation volume after radiofrequency ablation.
CONCLUSION: 3D SWE outperforms B-mode US in delineating ablated areas in the liver and is therefore more reliable for spatially delineating thermal lesions created by RF ablation. PMID: 25206291 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Sugimoto K, Oshiro H, Ogawa S, Honjo M, Hara T, Moriyasu F Tags: World J Gastroenterol Source Type: research

Role of multi-detector computed tomography for biliary complications after liver transplantation.
CONCLUSION: MDCT is a useful screening tool for detecting biliary complications after OLT. PMID: 25206292 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Meng XC, Huang WS, Xie PY, Chen XZ, Cai MY, Shan H, Zhu KS Tags: World J Gastroenterol Source Type: research

Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study.
CONCLUSION: Our results suggest that serum AFP levels are significantly associated with FLD and that AFP acts as a cofactor, but not as an independent factor, for FLD. PMID: 25206293 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Xu P, Xu CF, Wan XY, Yu CH, Shen C, Chen P, Xu GY, Li YM Tags: World J Gastroenterol Source Type: research

Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy.
CONCLUSION: A low immediate postoperative platelet count is an independent risk factor for hepatic insufficiency. Platelets can mediate liver regeneration in the cirrhotic liver. PMID: 25206294 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Wang HQ, Yang J, Yang JY, Wang WT, Yan LN Tags: World J Gastroenterol Source Type: research

Influence of a probiotic mixture on antibiotic induced microbiota disturbances.
CONCLUSION: Consumption of the probiotic combination mainly leads to an increase in the faecal levels of the species included in the preparation. PMID: 25206295 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Forssten S, Evans M, Wilson D, Ouwehand AC Tags: World J Gastroenterol Source Type: research

S-1-based vs non-S-1-based chemotherapy in advanced gastric cancer: A meta-analysis.
CONCLUSION: S-1-based chemotherapy may be a good choice for AGC because of longer survival times, better tolerance and more convenient use. PMID: 25206296 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Yang J, Zhou Y, Min K, Yao Q, Xu CN Tags: World J Gastroenterol Source Type: research

Manifestations of gastrointestinal plasmablastic lymphoma: A case series with literature review.
Abstract Plasmablastic lymphoma (PBL) rarely occurs in the gastrointestinal (GI) tract with limited studies reported. We reviewed the clinical histories and pathology of four patients with GI PBL at our institute and similar case reports published in peer-reviewed journals. In our first case, a 40 year-old human immunodeficiency virus positive male presented with a hemorrhoid-like sensation, and was diagnosed with PBL via biopsy of a rectal mass. The second case involves a 65 year-old healthy male with bloody diarrhea who was found to have PBL in a resected sigmoid mass. The third patient was a 41 year-old male wit...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Luria L, Nguyen J, Zhou J, Jaglal M, Sokol L, Messina JL, Coppola D, Zhang L Tags: World J Gastroenterol Source Type: research

Total pancreatectomy for metachronous mixed acinar-ductal carcinoma in a remnant pancreas.
In conclusion, we report here a rare case of repeated pancreatic resection for multicentric lesions of mixed acinar-ductal carcinoma of the pancreas. PMID: 25206298 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Shonaka T, Inagaki M, Akabane H, Yanagida N, Shomura H, Yanagawa N, Oikawa K, Nakano S Tags: World J Gastroenterol Source Type: research

Novel method to prevent gastric antral strictures after endoscopic submucosal dissection: Using triamcinolone.
Abstract Endoscopic submucosal dissection (ESD) of large gastric lesions often leads to severe gastric strictures, especially in cases of large ESD in the antrum of the stomach. It has recently been reported that balloon dilation, mucosal incision, and local steroid injections can successfully treat gastric strictures. However, there are some complications with existing methods and decreasing the quality of life. We have developed a novel method to prevent severe gastric strictures that does not involve balloon dilation, mucosal incision, or steroid injections after circumferential ESD. Our original method involves...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Nishiyama N, Mori H, Kobara H, Rafiq K, Fujihara S, Matsunaga T, Ayaki M, Yachida T, Oryu M, Masaki T Tags: World J Gastroenterol Source Type: research

Two cases of neuroendocrine carcinoma of the gallbladder.
In conclusion, NEC of the gallbladder is an aggressive tumor and the identification of a standardized optimal treatment still requires further research. Our experience together with published studies suggests that radical surgery and adjuvant chemotherapy may improve the prognosis. PMID: 25206300 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Chen H, Shen YY, Ni XZ Tags: World J Gastroenterol Source Type: research

Intestinal obstruction caused by extramedullary hematopoiesis and ascites in primary myelofibrosis.
Abstract Primary myelofibrosis (PMF) is a clonal hematopoietic stem cell disorder. It is characterized by bone marrow fibrosis, extramedullary hematopoiesis with hepatosplenomegaly and leukoerythroblastosis in the peripheral blood. The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever. Here we report a rare case of PMF with anemia, small bowel obstruction and ascites due to extramedullary hematopoiesis and portal hypertension. The diagnosis was difficult to establish before surgery and the differential diagnosis is discussed. PMID: 25206301 [PubMed - in process] (...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Wei XQ, Zheng ZH, Jin Y, Tao J, Abassa KK, Wen ZF, Shao CK, Wei HB, Wu B Tags: World J Gastroenterol Source Type: research

Pregnant inflammatory bowel disease patients may require counselling regarding live vaccines in newborns.
Abstract Inflammatory bowel disease patients are prone to immunosuppression due to effects of their medications. Physicians are recommended to assess vaccination status and overall health in all patients, prior to initiation of immunosuppressive therapy. Immunosuppressant medications in women with inflammatory bowel disease are often continued during pregnancy, which can result in newborns having an increased risk of immunosuppression at birth. While medication-induced immunosuppression in infants is transient, parents should be counselled about delaying live vaccine administration in newborns until they are immune...
Source: World Journal of Gastroenterology : WJG - September 7, 2014 Category: Gastroenterology Authors: Sekaran A, Borum ML Tags: World J Gastroenterol Source Type: research

Non-pulmonary allergic diseases and inflammatory bowel disease: A qualitative review.
Abstract While the etiological underpinnings of inflammatory bowel disease (IBD) are highly complex, it has been noted that both clinical and pathophysiological similarities exist between IBD and both asthma and non-pulmonary allergic phenomena. In this review, several key points on common biomarkers, pathophysiology, clinical manifestations and nutritional and probiotic interventions for both IBD and non-pulmonary allergic diseases are discussed. Histamine and mast cell activity show common behaviors in both IBD and in certain allergic disorders. IgE also represents a key immunoglobulin involved in both IBD and in...
Source: World Journal of Gastroenterology : WJG - August 28, 2014 Category: Gastroenterology Authors: Kotlyar DS, Shum M, Hsieh J, Blonski W, Greenwald DA Tags: World J Gastroenterol Source Type: research

Chronic hepatitis C and liver fibrosis.
Abstract Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality worldwide and predisposes to liver fibrosis and end-stage liver complications. Liver fibrosis is the excessive accumulation of extracellular matrix proteins, including collagen, and is considered as a wound healing response to chronic liver injury. Its staging is critical for the management and prognosis of chronic hepatitis C (CHC) patients, whose number is expected to rise over the next decades, posing a major health care challenge. This review provides a brief update on HCV epidemiology, summarizes...
Source: World Journal of Gastroenterology : WJG - August 28, 2014 Category: Gastroenterology Authors: Sebastiani G, Gkouvatsos K, Pantopoulos K Tags: World J Gastroenterol Source Type: research