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World Journal of Gastroenterology : WJG

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Hepatitis C-associated liver carcinogenesis: Role of PML nuclear bodies.
Abstract Successful escape from immune response characterises chronic hepatitis C virus (HCV) infection, which results in persistence of infection in about 80% of the patients. The deleterious consequences are cirrhosis and hepatocellular carcinoma. HCV accounts the most frequent cause for hepatocellular carcinoma (HCC) and liver transplantation (LT) in the western world. The underlying molecular mechanisms how HCV promotes tumor development are largely unknown. There is some in vitro and in vivo evidence that HCV interferes with the tumor suppressor PML and may thereby importantly contribute to the HCV-associated ...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Herzer K, Gerken G, Hofmann TG Tags: World J Gastroenterol Source Type: research

Extrahepatic immune related manifestations in chronic hepatitis C virus infection.
Abstract The association of chronic hepatitis C with immune related syndromes has been frequently reported. There is a great range of clinical manifestations affecting various systems and organs such as the skin, the kidneys, the central and peripheral nervous system, the musculoskeletal system and the endocrine glands. Despite the high prevalence of immune related syndromes in patients with chronic hepatitis C, the exact pathogenesis is not always clear. They have been often associated with mixed cryoglobulinemia, a common finding in chronic hepatitis C, cross reaction with viral antigens, or the direct effect of ...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Tampaki M, Koskinas J Tags: World J Gastroenterol Source Type: research

Smad3 phospho-isoform signaling in hepatitis C virus-related chronic liver diseases.
Abstract The risk of hepatocellular carcinoma (HCC) development increases as hepatitis virus C (HCV)-related liver diseases progress, especially in patients with active inflammation. Insight into hepatic carcinogenesis have emerged from recent detailed analyses of transforming growth factor-β and c-Jun-N-terminal kinase signaling processes directed by multiple phosphorylated (phospho)-isoforms of a Smad3 mediator. In the course of HCV-related chronic liver diseases, chronic inflammation and host genetic/epigenetic alterations additively shift the hepatocytic Smad3 phospho-isoform signaling from tumor suppression t...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Yamaguchi T, Yoshida K, Murata M, Matsuzaki K Tags: World J Gastroenterol Source Type: research

Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone?
Abstract Colorectal cancer (CRC) is one of the commonest cancers with 1.2 million new cases diagnosed each year in the world. It remains the fourth most common cause of cancer-related mortality in the world and accounts for > 600000 cancer-related deaths each year. There have been significant advances in treatment of metastatic CRC in last decade or so, due to availability of new active targeted agents and more aggressive approach towards the management of CRC, particularly with liver-only-metastases; however, these drugs work best when combined with conventional chemotherapy agents. Despite these advances, ther...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Khan K, Wale A, Brown G, Chau I Tags: World J Gastroenterol Source Type: research

Immune reaction and colorectal cancer: Friends or foes?
Abstract The potential clinical impact of enhancing antitumor immunity is increasingly recognized in oncology therapeutics for solid tumors. Colorectal cancer is one of the most studied neoplasms for the tumor-host immunity relationship. Although immune cell populations involved in such a relationship and their prognostic role in colorectal cancer development have clearly been identified, still no approved therapies based on host immunity intensification have so far been introduced in clinical practice. Moreover, a recognized risk in enhancing immune reaction for colitis-associated colorectal cancer development has...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Formica V, Cereda V, Nardecchia A, Tesauro M, Roselli M Tags: World J Gastroenterol Source Type: research

Early-onset colorectal cancer: A sporadic or inherited disease?
Abstract Colorectal cancer is the third most common cancer diagnosed worldwide. Although epidemiology data show a marked variability around the world, its overall incidence rate shows a slow but steady decrease, mainly in developed countries. Conversely, early-onset colorectal cancer appears to display an opposite trend with an overall prevalence in United States and European Union ranging from 3.0% and 8.6%. Colorectal cancer has a substantial proportion of familial cases. In particular, early age at onset is especially suggestive of hereditary predisposition. The clinicopathological and molecular features of colo...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Stigliano V, Sanchez-Mete L, Martayan A, Anti M Tags: World J Gastroenterol Source Type: research

Occupational exposures and colorectal cancers: A quantitative overview of epidemiological evidence.
Abstract A traditional belief widespread across the biomedical community was that dietary habits and genetic predisposition were the basic factors causing colorectal cancer. In more recent times, however, a growing evidence has shown that other determinants can be very important in increasing (or reducing) incidence of this malignancy. The hypothesis that environmental and occupational risk factors are associated with colorectal cancer is gaining ground, and high risks of colorectal cancer have been reported among workers in some industrial branches. The aim of this study was to investigate the epidemiologic relati...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Oddone E, Modonesi C, Gatta G Tags: World J Gastroenterol Source Type: research

Improving the outcomes in oncological colorectal surgery.
Abstract During the last several decades, colorectal cancer surgery has experienced some major perioperative improvements. Preoperative risk-assessment of nutrition, frailty, and sarcopenia followed by interventions for patient optimization or an adapted surgical strategy, contributed to improved postoperative outcomes. Enhanced recovery programs or fast-track surgery also resulted in reduced length of hospital stay and overall complications without affecting patient safety. After an initially indecisive start due to uncertainty about oncological safety, the most significant improvement in intraoperative care was t...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: van Vugt JL, Reisinger KW, Derikx JP, Boerma D, Stoot JH Tags: World J Gastroenterol Source Type: research

Clinical impact of minimal cancer cell detection in various colorectal cancer specimens.
Abstract Detection of cancer cells using molecular targets is achieved by combining immunochemical reactions with gene amplification techniques. This enables the detection of cancer cells in specimens that are traditionally determined to be cancer-free. These improvements in detection can lead to prognoses that are different from those derived by conventional pathological staging. Survival is worse when cancer cells are detected in regional lymph nodes compared to when the nodes are cancer-free. Furthermore, the circulating tumor cell (CTC) count increases as the cancer progresses. Consequently, there is a correlat...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Yoshimatsu K, Yokomizo H, Naritaka Y Tags: World J Gastroenterol Source Type: research

Potential mechanisms of hepatitis B virus induced liver injury.
Abstract Chronic active hepatitis (CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma. The histological end points of CAH are chronic inflammation, fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers. The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis, inflammation and cytokine production and liver scaring (fibrosis). The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components. The viral and cellular factors ...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Suhail M, Abdel-Hafiz H, Ali A, Fatima K, Damanhouri GA, Azhar E, Chaudhary AG, Qadri I Tags: World J Gastroenterol Source Type: research

Resection of hepatitis B virus-related hepatocellular carcinoma: Evolving strategies and emerging therapies to improve outcome.
Abstract The incidence of hepatocellular carcinoma (HCC) is increasing worldwide, largely due to hepatitis B virus (HBV), hepatitis C virus and liver cirrhosis. Chronic HBV infection is estimated to cause 55%-60% of the cases of HCC worldwide and over 70% in Asian countries. Liver resection is currently the mainstay of treatment due to the low surgical mortality, a wider treatment indication, and simplicity of post-treatment follow-up. There is an ever-increasing demand on surgeons to perform curative liver resection in HCC, with the hope of avoiding tumor recurrences. Hepatitis B-related-HCC has distinct clinicopa...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Chau GY Tags: World J Gastroenterol Source Type: research

Biosensors for hepatitis B virus detection.
Abstract A biosensor is an analytical device used for the detection of analytes, which combines a biological component with a physicochemical detector. Recently, an increasing number of biosensors have been used in clinical research, for example, the blood glucose biosensor. This review focuses on the current state of biosensor research with respect to efficient, specific and rapid detection of hepatitis B virus (HBV). The biosensors developed based on different techniques, including optical methods (e.g., surface plasmon resonance), acoustic wave technologies (e.g., quartz crystal microbalance), electrochemistry (...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Yao CY, Fu WL Tags: World J Gastroenterol Source Type: research

Current treatment options for colon cancer peritoneal carcinomatosis.
Abstract Peritoneal carcinomatosis (PC), the dissemination of cancer cells throughout the lining of the abdominal cavity, is the second most common presentation of colon cancer distant metastasis. Despite remarkable advances in cytotoxic chemotherapy and targeted therapy for colon cancer over the last 15 years, it has been repeatedly shown that these therapies remain ineffective for colon cancer PC. Recently, there has been a rapid accumulation of reports that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) prolongs the life of colon cancer PC patients. Here, we will review...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Aoyagi T, Terracina KP, Raza A, Takabe K Tags: World J Gastroenterol Source Type: research

Treatment for superficial non-ampullary duodenal epithelial tumors.
Abstract Because of the low prevalence of non-ampullary duodenal epithelial tumors (NADETs), standardized clinical management of sporadic superficial NADETs, including diagnosis, treatment, and follow-up, has not yet been established. Retrospective studies have revealed certain endoscopic findings suggestive of malignancy. Duodenal adenoma with high-grade dysplasia and mucosal cancer are candidates for local resection by endoscopic or minimally invasive surgery. The use of endoscopic treatment including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), for the treatment for superficial ...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Kakushima N, Kanemoto H, Tanaka M, Takizawa K, Ono H Tags: World J Gastroenterol Source Type: research

Routine colonic endoscopic evaluation following resolution of acute diverticulitis: Is it necessary?
Abstract Diverticular disease incidence is increasing up to 65% by age 85 in industrialized nations, low fiber diets, and in younger and obese patients. Twenty-five percent of patients with diverticulosis will develop acute diverticulitis. This imposes a significant burden on healthcare systems, resulting in greater than 300000 admissions per year with an estimated annual cost of $3 billion USD. Abdominal computed tomography (CT) is the diagnostic study of choice, with a sensitivity and specificity greater than 95%. Unfortunately, similar CT findings can be present in colonic neoplasia, especially when perforated o...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Agarwal AK, Karanjawala BE, Maykel JA, Johnson EK, Steele SR Tags: World J Gastroenterol Source Type: research

Eltrombopag in chronic hepatitis C.
We present a minireview on the results of treatment with eltrombopag in patients chronically infected with hepatitis C virus, highlighting the benefits and mentioning possible adverse effects. In some studies eltrombopag increased the number of virological responses after clasical antiviral treatment of patients with chronic hepatitis C and reduced the transfusional requirements of those who had to be subjected to invasive surgery. Eltrombopag is a solution for many of these patients, which allows them receiving antiviral therapy and sometimes getting a sustained virological response, but they must be well monitored to pre...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Mihăilă RG, Cipăian RC Tags: World J Gastroenterol Source Type: research

Mitotic crossover - an evolutionary rudiment which promotes carcinogenesis of colorectal carcinoma.
Abstract Mitotic crossover is a natural mechanism that is a main source of the genetic variability of primitive organisms. In complex organisms such as mammals, it represents an evolutionary rudiment which persisted as one of the numerous DNA repair mechanisms, and results in the production of homozygous allele combinations in all heterozygous genes located on the chromosome arm distal to the crossover. This event is familiar as loss of heterozygosity, which is one of the key mechanisms responsible for the development and progression of almost all cancers. We propose the hypothesis in which mitotic crossover is a p...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Rovcanin B, Ivanovski I, Djuric O, Nikolic D, Petrovic J, Ivanovski P Tags: World J Gastroenterol Source Type: research

Necroptosis: An emerging type of cell death in liver diseases.
Abstract Cell death has been extensively evaluated for decades and it is well recognized that pharmacological interventions directed to inhibit cell death can prevent significant cell loss and can thus improve an organ's physiological function. For long, only apoptosis was considered as a sole form of programmed cell death. Recently necroptosis, a RIP1/RIP3-dependent programmed cell death, has been identified as an apoptotic backup cell death mechanism with necrotic morphology. The evidences of necroptosis and protective effects achieved by blocking necroptosis have been extensively reported in recent past. However...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Saeed WK, Jun DW Tags: World J Gastroenterol Source Type: research

Protective action of NADPH oxidase inhibitors and role of NADPH oxidase in pathogenesis of colon inflammation in mice.
CONCLUSION: Our study revealed the importance of NADPH oxidase in the pathogenesis of both acute and chronic inflammation of the colon. PMID: 25253955 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Ramonaite R, Skieceviciene J, Juzenas S, Salteniene V, Kupcinskas J, Matusevicius P, Borutaite V, Kupcinskas L Tags: World J Gastroenterol Source Type: research

Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma.
CONCLUSION: Gastrin stimulates proliferation of HT-29 cells and inhibits apoptosis by upregulating phosphorylation of ERK and K-ras through the Ras-Raf-MEK1/2-ERK1/2 pathway, and this is restrained by proglumide. PMID: 25253956 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Mao JD, Wu P, Huang JX, Wu J, Yang G Tags: World J Gastroenterol Source Type: research

Extraesophageal saline enhances endoscopic ultrasonography to differentiate esophagus and adjacent organs.
CONCLUSION: The esophagus and adjacent organs were successfully separated by ESI, and extraesophageal saline acted as an effective ultrasonic contrast agent. PMID: 25253957 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Li JJ, Shan HB, He LJ, Wang TD, Xiong H, Chen LM, Li XH, Huang XX, Luo GY, Li Y, Xu GL Tags: World J Gastroenterol Source Type: research

Polymorphism of heat shock protein 70-2 and enterocutaneous fistula in Chinese population.
CONCLUSION: The A allele of the HSP70-2 PstI polymorphism was associated with enterocutaneous fistulas in this Chinese population. PMID: 25253958 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Chen J, Ren JA, Han G, Gu GS, Wang GF, Wu XW, Zhou B, Hu D, Wu Y, Zhao YZ, Li JS Tags: World J Gastroenterol Source Type: research

Serum immunoglobulin A concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease.
CONCLUSION: The serum IgA level is useful to evaluate the severity of liver fibrosis and can be used serially for evaluation and follow-up of NAFLD cases. PMID: 25253959 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Maleki I, Aminafshari MR, Taghvaei T, Hosseini V, Rafiei A, Torabizadeh Z, Barzin M, Orang E Tags: World J Gastroenterol Source Type: research

Parameters of a severe disease course in ulcerative colitis.
CONCLUSION: Using six simple clinical parameters, we can estimate the patients individual risk of developing a progressive disease course. PMID: 25253960 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Stallmach A, Nickel L, Lehmann T, Bokemeyer B, Bürger M, Hüppe D, Kruis W, Nikolaus S, Preiss JC, Sturm A, Teich N, Schmidt C Tags: World J Gastroenterol Source Type: research

Indicators of sorafenib efficacy in patients with advanced hepatocellular carcinoma.
CONCLUSION: Extrahepatic major HCC and HFS are associated with prolonged TTP and are useful indicators for judging the efficacy of sorafenib treatment. PMID: 25253961 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Yada M, Masumoto A, Motomura K, Tajiri H, Morita Y, Suzuki H, Senju T, Koyanagi T Tags: World J Gastroenterol Source Type: research

Short-term interval combined chemoembolization and radiofrequency ablation for hepatocellular carcinoma.
CONCLUSION: The combined TACE and RFA with an interval of 0-2 d are safe for the management of HCC < 5 cm in cirrhotic patients. PMID: 25253962 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Choe WH, Kim YJ, Park HS, Park SW, Kim JH, Kwon SY Tags: World J Gastroenterol Source Type: research

Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: A single-center experience.
CONCLUSION: Preoperative differential diagnosis relies on the integration of information, including clinical symptoms, laboratory findings and imaging results. PMID: 25253963 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH Tags: World J Gastroenterol Source Type: research

Botulinum toxin type-A injection to treat patients with intractable anismus unresponsive to simple biofeedback training.
CONCLUSION: BTX-A injection combined with pelvic floor biofeedback training seems to be successful for intractable anismus. PMID: 25253964 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Zhang Y, Wang ZN, He L, Gao G, Zhai Q, Yin ZT, Zeng XD Tags: World J Gastroenterol Source Type: research

Cardiac surgery in patients with liver cirrhosis: Risk factors for predicting mortality.
CONCLUSION: Advanced liver cirrhosis should not preclude patients from cardiac surgery. Preoperative serum bilirubin, the EuroSCORE, and CABG are major predictors of early and late mortality. PMID: 25253965 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Lin CH, Hsu RB Tags: World J Gastroenterol Source Type: research

Risk factors for combined hepatocellular-cholangiocarcinoma: A hospital-based case-control study.
CONCLUSION: HBV infection and heavy alcohol consumption may play a role in the development of CHC in China. PMID: 25253966 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Zhou YM, Zhang XF, Wu LP, Sui CJ, Yang JM Tags: World J Gastroenterol Source Type: research

Optimal b value of diffusion-weighted imaging on a 3.0T magnetic resonance scanner in Crohn's disease.
CONCLUSION: High b value is suitable for intestinal DW examination on a high field MR scanner. PMID: 25253967 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Feng Q, Yan YQ, Zhu J, Tong JL, Xu JR Tags: World J Gastroenterol Source Type: research

Contrast-enhanced ultrasound: Improving the preoperative staging of hepatocellular carcinoma and guiding individual treatment.
CONCLUSION: CEUS combined with CT or MRI improves the accuracy of preoperative staging for hepatocellular carcinoma and may help to guide individualized treatment for patients with HCC. CEUS may better identify non-malignant lesions in patients with small tumors and discover new malignant lesions in patients with large tumors. PMID: 25253968 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Zhang XY, Luo Y, Wen TF, Jiang L, Li C, Zhong XF, Zhang JY, Ling WW, Yan LN, Zeng Y, Wu H Tags: World J Gastroenterol Source Type: research

Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis.
CONCLUSION: This systematic review identified only one randomized clinical trial and seven therapeutic agents from pre-clinical models that could be explored further for the prophylaxis of AL after colorectal surgery. PMID: 25253969 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Oines MN, Krarup PM, Jorgensen LN, Agren MS Tags: World J Gastroenterol Source Type: research

Kudo's pit pattern classification for colorectal neoplasms: A meta-analysis.
CONCLUSION: Kudo's pit pattern classification is an accurate diagnostic method for the differentiation of neoplastic colorectal lesions. Publication bias is significant in the current available literature. PMID: 25253970 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Li M, Ali SM, Umm-A-OmarahGilani S, Liu J, Li YQ, Zuo XL Tags: World J Gastroenterol Source Type: research

Hepatoid adenocarcinoma of the colon in a patient with inflammatory bowel disease.
Abstract A case is presented of a 36-year-old male with primary sclerosing cholangitis-associated inflammatory bowel disease (PSC-IBD) and two synchronous stage 1 adenocarcinomata of the colon, who was initially treated with a subtotal colectomy with ileostomy. One year later, the patient presented with extensive intra-abdominal lymphadenopathy and peritoneal carcinomatosis, as well as a markedly elevated serum level of alpha-fetoprotein (AFP). Fine needle aspiration biopsy of a porta hepatis lymph node revealed a metastatic hepatoid adenocarcinoma. Subsequent review of the previous colectomy specimen showed that o...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Chen Y, Schaeffer DF, Yoshida EM Tags: World J Gastroenterol Source Type: research

Association of autoimmune hepatitis and systemic lupus erythematodes: A case series and review of the literature.
Abstract Liver test abnormalities have been described in up to 60% of patients with systemic lupus erythematodes (SLE) at some point during the course of their disease. Prior treatment with potentially hepatotoxic drugs or viral hepatitis is commonly considered to be the main cause of liver disease in SLE patients. However, in rare cases elevated liver enzymes may be due to concurrent autoimmune hepatitis (AIH). To distinguish whether the patient has primary liver disease with associated autoimmune clinical and laboratory features resembling SLE - such as AIH - or the elevation of liver enzymes is a manifestation o...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Beisel C, Weiler-Normann C, Teufel A, Lohse AW Tags: World J Gastroenterol Source Type: research

Ruptured gastric artery aneurysm: An uncommon manifestation of microscopic polyangiitis.
We describe herein the clinical course of a patient with a ruptured gastric artery aneurysm associated with microscopic polyangiitis. Absence of vasculitic changes in the aneurysm resected and negative results of autoantibodies interfered with our diagnostic process. We should have adopted an interventional radiology and initiated steroid therapy promptly to rescue the patient. PMID: 25253973 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Ikura Y, Kadota T, Watanabe S, Arimoto A, Nishioka E Tags: World J Gastroenterol Source Type: research

Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings.
Abstract Basaloid squamous carcinoma (BSC) is a rare variant of esophageal cancer. There are very few reports of "early" BSC. Here we report a case of early BSC with unusual findings by narrowband imaging magnified endoscopy (NBI-ME). A 70-year-old man with a middle thoracic esophageal tumor was referred to our hospital. White-light endoscopy revealed a reddish depressed lesion 5 mm in diameter having a subepithelial tumor-like prominence with a gentle rising slope. NBI-ME revealed irregular loop-shaped microvessels coexistent with thick irregularly branched non-looped vessels. Iodine staining revealed a pale brown...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Kai Y, Kato M, Hayashi Y, Akasaka T, Shinzaki S, Nishida T, Tsujii M, Morii E, Takehara T Tags: World J Gastroenterol Source Type: research

Intussusception due to rectal adenocarcinoma in a young adult: A case report.
In this report, the case of a young man with rectal adenocarcinoma causing intussusception is described. A 24-year-old man visited a hospital complaining of abdominal pain, and an upper rectal cancer was diagnosed by colonoscopy. Computed tomography showed intussusception caused by a large tumor in the pelvis and absence of distant metastases. Locally advanced rectal cancer causing intussusception was diagnosed, and a low anterior resection was performed. Intraoperatively, repair of the invagination could not be accomplished easily; therefore, the repair was abandoned. Instead, the tumor was removed en bloc to avoid dissem...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Inada R, Nagasaka T, Toshima T, Mori Y, Kondo Y, Kishimoto H, Fujiwara T Tags: World J Gastroenterol Source Type: research

Pancreatic adenocarcinosarcoma of monoclonal origin: A case report.
Abstract Adenocarcinosarcoma, a neoplasm containing both carcinomatous and sarcomatous components, is a rare form of a cancer and the pathophysiology is currently poorly understood. Moreover, definitive treatment guidelines for this disease have not yet been established. Pancreatic adenocarcinosarcoma is even more rare and the prognosis is fatal. Here, we report a case of a 77-year-old male with pancreatic adenocarcinosarcoma and metastasis to the liver. The patient presented at our hospital with uncontrolled glucose levels and diabetes mellitus. The patient's laboratory findings were unremarkable with the exceptio...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Kim HS, Kim JI, Jeong M, Seo JH, Kim IK, Cheung DY, Kim TJ, Kang CS Tags: World J Gastroenterol Source Type: research

A case of Clostridium difficile infection complicated by acute respiratory distress syndrome treated with fecal microbiota transplantation.
Abstract Acute respiratory distress syndrome is a life-threatening disorder caused mainly by pneumonia. Clostridium difficile infection (CDI) is a common nosocomial diarrheal disease. Disruption of normal intestinal flora by antibiotics is the main risk factor for CDI. The use of broad-spectrum antibiotics for serious medical conditions can make it difficult to treat CDI complicated by acute respiratory distress syndrome. Fecal microbiota transplantation is a highly effective treatment in patients with refractory CDI. Here we report on a patient with refractory CDI and acute respiratory distress syndrome caused by ...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Kim JE, Gweon TG, Yeo CD, Cho YS, Kim GJ, Kim JY, Kim JW, Kim H, Lee HW, Lim T, Ham H, Oh HJ, Lee Y, Byeon J, Park SS Tags: World J Gastroenterol Source Type: research

Esophageal squamous cell carcinoma with dural and bone marrow metastases.
Abstract Patients with esophageal squamous cell carcinoma generally present at an advanced stage at the time of diagnosis. The most common sites of visceral metastasis are the lung, liver and bone, but brain and bone marrow involvement is exceedingly rare. Herein, we report a 62-year-old man with a 4-wk history of progressive low back pain with radiation to bilateral lower legs, dysphagia and body weight loss. Esophageal squamous cell carcinoma with regional lymph node, liver and bone metastases was diagnosed. He underwent concurrent chemoradiotherapy and got a partial response. Four months later, he complained of ...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Chen YH, Huang CH Tags: World J Gastroenterol Source Type: research

Successful surgical strategy in a late case of Boerhaave's syndrome.
We present a case of Boerhaave's syndrome in which the patient underwent surgical repair 48 h after the acute event and was subsequently treated successfully. The initial approach included direct esophageal repair, a drainage series, and nutritional support via a feeding jejunostomy. Although the repair site was subsequently disrupted, the patient showed complete healing of the perforation after three weeks. We consider that our surgical treatment strategy is safe and technically feasible, and appears to be a promising alternative approach for the treatment of patients with late Boerhaave's perforation. PMID: 25253979...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Shen G, Chai Y, Zhang GF Tags: World J Gastroenterol Source Type: research

Successful esophagectomy in a patient with combined esophageal cancer and hemophilia B.
We report the case of a 45-year-old man with esophageal cancer and hemophilia B who underwent a successful hybrid, minimally invasive Ivor-Lewis esophagectomy with appropriate perioperative management. PMID: 25253980 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Zhang GF, Chai Y, Li WS, Huang LS, Shen G Tags: World J Gastroenterol Source Type: research

Rare cause of upper gastrointestinal bleeding owing to hepatic cancer invasion: A case report.
We report a rare case of gastrointestinal bleeding with hepatocellular carcinoma in a patient who presented with recurrent gastrointestinal bleeding. The initial diagnosis was gastric cancer with metastasis to the multiple lymph nodes of the lesser curvature. The patient underwent exploratory laparotomy, which identified two lesions in the gastric wall. Total gastrectomy and hepatic local excision was then performed. Pathological results indicated that the hepatocellular carcinoma had invaded the stomach directly, which was confirmed immunohistochemically. The patient is alive with a disease-free survival of 1 year since t...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Wu WD, Wu J, Yang HG, Chen Y, Zhang CW, Zhao DJ, Hu ZM Tags: World J Gastroenterol Source Type: research

May bacterial or pancreatic proteases play a critical role in inflammatory bowel disease?
Abstract In a recent review paper, Carroll and Maharshak discussed a critical role of enteric bacterial proteases in the pathogenesis of inflammatory bowel disease (IBD). I take a great interest in this paper as I also suspected proteases, not from the bacteria, but those originated from the pancreas that failed to be inactivated in the lower gut due to a reduction in gut bacteria, may have played a critical role in the pathogenesis of IBD, which was first published more than a decade ago and discussed again in more detail in a recent paper published in this journal. Antibiotics may result in a big reduction in gut...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Qin X Tags: World J Gastroenterol Source Type: research

Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?
Abstract Red cell distribution width (RDW) may play an important role in predicting steatohepatitis and liver fibrosis. In the original study, it was aimed to determine whether RDW could be used for this purpose or not. There are studies indicating that higher RDW is correlated well with components of metabolic syndrome. Because nonalcoholic fatty liver disease is now recognized as the hepatic manifestation of metabolic syndrome, possible impact of the accompanying confounders on the study findings should have been detailed. There may be a patient selection bias due to use of improper cut-off values for alcohol con...
Source: World Journal of Gastroenterology : WJG - September 21, 2014 Category: Gastroenterology Authors: Kayadibi H, Sertoglu E, Uyanik M, Tapan S Tags: World J Gastroenterol Source Type: research

Alcoholic hepatitis and concomitant hepatitis C virus infection.
Abstract Hepatitis C virus (HCV) infection and alcohol abuse are two most important causes of chronic liver disease in the United States. Alcoholic hepatitis is a unique clinical syndrome among patients with chronic and active alcohol abuse with a potential for high short-term mortality. About 20% of patients presenting with alcoholic hepatitis have concomitant HCV infection. Mortality from alcoholic hepatitis is increased in the presence of concomitant hepatitis C due to synergistic interaction between HCV and alcohol in causing hepatocellular damage. Large prospective randomized studies are needed to develop guid...
Source: World Journal of Gastroenterology : WJG - September 14, 2014 Category: Gastroenterology Authors: Shoreibah M, Anand BS, Singal AK Tags: World J Gastroenterol Source Type: research

Outcomes after liver transplantation for combined alcohol and hepatitis C virus infection.
Abstract Alcohol abuse and chronic hepatitis C virus (HCV) infection are two major causes of chronic liver disease in the United States. About 10%-15% of liver transplants performed in the United States are for patients with cirrhosis due to combined alcohol and HCV infection. Data on outcomes on graft and patient survival, HCV recurrence, and relapse of alcohol use comparing transplants in hepatitis C positive drinkers compared to alcohol abuse or hepatitis C alone are conflicting in the literature. Some studies report a slightly better overall outcome in patients who were transplanted for alcoholic cirrhosis vs t...
Source: World Journal of Gastroenterology : WJG - September 14, 2014 Category: Gastroenterology Authors: Khan R, Singal AK, Anand BS Tags: World J Gastroenterol Source Type: research

Helicobacter pylori vaccination: Is there a path to protection?
Abstract Helicobacter pylori (H. pylori) is a pathogenic, extracellular bacterium that colonizes the stomach in approximately 50% of the world population. It strongly interacts with the gastric epithelium and mostly causes asymptomatic gastritis. The colonization of H. pylori leads to ulcer development in around 20% of infected patients and may progress to gastric cancer or mucosa-associated lymphoid tissue lymphoma in 1%. Thus, H. pylori is the major cause of gastric cancer worldwide. It has been classified as a class I carcinogen by the World Health Organization. Since its discovery in the early eighties by W...
Source: World Journal of Gastroenterology : WJG - September 14, 2014 Category: Gastroenterology Authors: Anderl F, Gerhard M Tags: World J Gastroenterol Source Type: research