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Symbiotic chemo- and immuno-therapy for hepatitis B and C viruses.
Abstract Hepatitis B and C viruses (HBV and HCV), both cause serious chronic infections leading to fatal liver diseases. The prototype therapy for both HBV and HCV was based on IFN-α with or without ribavirin. The advent of direct-acting antivirals (DAA) for both HBV and HCV has remarkably improved the standard of treatment for both infections. While HCV can be eliminated following combination DAA therapy, HBV persists even after treatment, requiring life-long therapy with DAAs. Treatment with DAAs is also associated with high cost, the development of resistance and side effects. There is ample published evidence ...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Agrawal B, Kumar R Tags: World J Gastroenterol Source Type: research

Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids.
Abstract Despite recent advances in surgical techniques and perioperative management, the prognosis of pancreatic cancer (PCa) remains extremely poor. To provide optimal treatment for each patient with Pca, superior biomarkers are urgently needed in all phases of management from early detection to staging, treatment monitoring, and prognosis. In the blood of patients with cancer, circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs), such as DNA, mRNA, and noncoding RNA have been recognized. In the recent years, their presence in the blood has encouraged researchers to investigate their potential use a...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Imamura T, Komatsu S, Ichikawa D, Kawaguchi T, Miyamae M, Okajima W, Ohashi T, Arita T, Konishi H, Shiozaki A, Morimura R, Ikoma H, Okamoto K, Otsuji E Tags: World J Gastroenterol Source Type: research

Light and sound - emerging imaging techniques for inflammatory bowel disease.
Abstract Patients with inflammatory bowel disease are known to have a high demand of recurrent evaluation for therapy and disease activity. Further, the risk of developing cancer during the disease progression is increasing from year to year. New, mostly non-radiant, quick to perform and quantitative methods are challenging, conventional endoscopy with biopsy as gold standard. Especially, new physical imaging approaches utilizing light and sound waves have facilitated the development of advanced functional and molecular modalities. Besides these advantages they hold the promise to predict personalized therapeutic r...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Knieling F, Waldner MJ Tags: World J Gastroenterol Source Type: research

Oral pathology in inflammatory bowel disease.
Abstract The incidence of inflammatory bowel diseases (IBD) - Crohn's disease (CD) and ulcerative colitis (UC) - has been increasing on a global scale, and progressively, more gastroenterologists will be included in the diagnosis and treatment of IBD. Although IBD primarily affects the intestinal tract, extraintestinal manifestations of the disease are often apparent, including in the oral cavity, especially in CD. Specific oral manifestations in patients with CD are as follows: indurate mucosal tags, cobblestoning and mucogingivitis, deep linear ulcerations and lip swelling with vertical fissures. The most common ...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Muhvić-Urek M, Tomac-Stojmenović M, Mijandrušić-Sinčić B Tags: World J Gastroenterol Source Type: research

Genomic diversity of colorectal cancer: Changing landscape and emerging targets.
Abstract Improvements in screening and preventive measures have led to an increased detection of early stage colorectal cancers (CRC) where patients undergo treatment with a curative intent. Despite these efforts, a high proportion of patients are diagnosed with advanced stage disease that is associated with poor outcomes, as CRC remains one of the leading causes of cancer-related deaths in the world. The development of next generation sequencing and collaborative multi-institutional efforts to characterize the cancer genome has afforded us with a comprehensive assessment of the genomic makeup present in CRC. This ...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Ahn DH, Ciombor KK, Mikhail S, Bekaii-Saab T Tags: World J Gastroenterol Source Type: research

New trends in molecular and cellular biomarker discovery for colorectal cancer.
Abstract Colorectal cancer (CRC) is the third leading cause of cancer death worldwide, which is consequence of multistep tumorigenesis of several genetic and epigenetic events. Since CRC is mostly asymptomatic until it progresses to advanced stages, the early detection using effective screening approaches, selection of appropriate therapeutic strategies and efficient follow-up programs are essential to reduce CRC mortalities. Biomarker discovery for CRC based on the personalized genotype and clinical information could facilitate the classification of patients with certain types and stages of cancer to tailor preven...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Aghagolzadeh P, Radpour R Tags: World J Gastroenterol Source Type: research

Laparoscopic and robot-assisted gastrectomy for gastric cancer: Current considerations.
Abstract Radical gastrectomy with an adequate lymphadenectomy is the main procedure which makes it possible to cure patients with resectable gastric cancer (GC). A number of randomized controlled trials and meta-analysis provide phase III evidence that laparoscopic gastrectomy is technically safe and that it yields better short-term outcomes than conventional open gastrectomy for early-stage GC. While laparoscopic gastrectomy has become standard therapy for early-stage GC, especially in Asian countries such as Japan and South Korea, the use of minimally invasive techniques is still controversial for the treatment o...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Caruso S, Patriti A, Roviello F, De Franco L, Franceschini F, Coratti A, Ceccarelli G Tags: World J Gastroenterol Source Type: research

Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis.
Abstract Anastomotic leakage (AL) is one of the most devastating complications after rectal cancer surgery. The double stapling technique has greatly facilitated intestinal reconstruction especially for anastomosis after low anterior resection (LAR). Risk factor analyses for AL after open LAR have been widely reported. However, a few studies have analyzed the risk factors for AL after laparoscopic LAR. Laparoscopic rectal surgery provides an excellent operative field in a narrow pelvic space, and enables total mesorectal excision surgery and preservation of the autonomic nervous system with greater precision. Howev...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Kawada K, Sakai Y Tags: World J Gastroenterol Source Type: research

Hepatopulmonary syndrome: What we know and what we would like to know.
Abstract Hepatopulmonary syndrome (HPS) is characterized by abnormalities in blood oxygenation caused by the presence of intrapulmonary vascular dilations (IPVD) in the context of liver disease, generally at a cirrhotic stage. Knowledge about the subject is still only partial. The majority of the information about the etiopathogenesis of HPS has been obtained through experiments on animals. Reported prevalence in patients who are candidates for a liver transplantation (LT) varies between 4% and 32%, with a predominance of mild or moderate cases. Although it is generally asymptomatic it does have an impact on their ...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Grilo-Bensusan I, Pascasio-Acevedo JM Tags: World J Gastroenterol Source Type: research

Gut dysfunction in Parkinson's disease.
Abstract Early involvement of gut is observed in Parkinson's disease (PD) and symptoms such as constipation may precede motor symptoms. α-Synuclein pathology is extensively evident in the gut and appears to follow a rostrocaudal gradient. The gut may act as the starting point of PD pathology with spread toward the central nervous system. This spread of the synuclein pathology raises the possibility of prion-like propagation in PD pathogenesis. Recently, the role of gut microbiota in PD pathogenesis has received attention and some phenotypic correlation has also been shown. The extensive involvement of the gut in P...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Mukherjee A, Biswas A, Das SK Tags: World J Gastroenterol Source Type: research

Acetic acid chromoendoscopy: Improving neoplasia detection in Barrett's esophagus.
Abstract Barrett's esophagus (BE) is an important condition given its significant premalignant potential and dismal five-year survival outcomes of advanced esophageal adenocarcinoma. It is therefore suggested that patients with a diagnosis of BE undergo regular surveillance in order to pick up dysplasia at an earlier stage to improve survival. Current "gold-standard" surveillance protocols suggest targeted biopsy of visible lesions followed by four quadrant random biopsies every 2 cm. However, this method of Barrett's surveillance is fraught with poor endoscopist compliance as the procedures are time consuming and ...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Chedgy FJ, Subramaniam S, Kandiah K, Thayalasekaran S, Bhandari P Tags: World J Gastroenterol Source Type: research

Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats.
CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying. PMID: 27433089 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Matos JF, Americo MF, Sinzato YK, Volpato GT, Corá LA, Calabresi MF, Oliveira RB, Damasceno DC, Miranda JR Tags: World J Gastroenterol Source Type: research

Urotensin II-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in HepG2 cells.
CONCLUSION: UII induces insulin resistance, and this can be reversed by JNK inhibitor SP600125 and antioxidant/NADPH oxidase inhibitor apocynin targeting the insulin signaling pathway in HepG2 cells. PMID: 27433090 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Li YY, Shi ZM, Yu XY, Feng P, Wang XJ Tags: World J Gastroenterol Source Type: research

Nationwide trends and predictors of inpatient mortality in 83884 transjugular intrahepatic portosystemic shunt.
CONCLUSION: The overall mortality of the TIPS procedure is steadily decreasing, though the length of stay has remained relatively constant. Specific patient ethnicity, location, transfer status, primary diagnosis and comorbidities correlate with increased odds of TIPS in-hospital death. PMID: 27433091 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Lee EW, Kuei A, Saab S, Busuttil RW, Durazo F, Han SH, El-Kabany MM, McWilliams JP, Kee ST Tags: World J Gastroenterol Source Type: research

Clinical analysis of patients with hepatocellular carcinoma recurrence after living-donor liver transplantation.
CONCLUSION: Curative treatment for recurrent HCC after LDLT is the most important factor in survival rates after HCC recurrence and combination treatments of sorafenib and an mTOR inhibitor could have survival benefits in patients with HCC recurrence after LT in the palliative treatment group. PMID: 27433092 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Na GH, Hong TH, You YK, Kim DG Tags: World J Gastroenterol Source Type: research

Acceptance of living liver donation among medical students: A multicenter stratified study from Spain.
CONCLUSION: Spanish medical students have a favorable attitude toward LLD. PMID: 27433093 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Ríos A, López-Navas AI, López-López AI, Gómez FJ, Iriarte J, Herruzo R, Blanco G, Llorca FJ, Asunsolo A, Sánchez-Gallegos P, Gutiérrez PR, Fernández A, de Jesús MT, Martínez-Alarcón L, Lana A, Fuentes L, Hernández JR, Virseda J, Yelamos J, Bon Tags: World J Gastroenterol Source Type: research

Low expression of ARID1A correlates with poor prognosis in intrahepatic cholangiocarcinoma.
CONCLUSION: Low expression of ARID1A is associated with poor prognosis in patients with IHCC, and thus may be a potential prognostic biomarker candidate in IHCC. PMID: 27433094 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Yang SZ, Wang AQ, Du J, Wang JT, Yu WW, Liu Q, Wu YF, Chen SG Tags: World J Gastroenterol Source Type: research

Establishment of a nested-ASP-PCR method to determine the clarithromycin resistance of Helicobacter pylori.
CONCLUSION: The nested-ASP-PCR assay showed higher detection sensitivity than ASP-PCR and drug sensitivity testing, which could be performed to evaluate clarithromycin resistance of H. pylori. PMID: 27433095 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Luo XF, Jiao JH, Zhang WY, Pu HM, Qu BJ, Yang BY, Hou M, Ji MJ Tags: World J Gastroenterol Source Type: research

Hemostatic effect of topical hemocoagulase spray in digestive endoscopy.
CONCLUSION: Topical hemocoagulase spray has a definite hemostatic effect for oozing bleeding in digestive endoscopy, and this method is convenient, safe, and reliable. It is expected to become a new method for endoscopic hemostasis. PMID: 27433096 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Wang T, Wang DN, Liu WT, Zheng ZQ, Chen X, Fang WL, Li S, Liang L, Wang BM Tags: World J Gastroenterol Source Type: research

Towards safe injection practices for prevention of hepatitis C transmission in South Asia: Challenges and progress.
CONCLUSION: Injection use is common in South Asian countries. Multilevel interventions aiming at patients, providers and the healthcare system are needed to reduce injection use and reuse. PMID: 27433097 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Janjua NZ, Butt ZA, Mahmood B, Altaf A Tags: World J Gastroenterol Source Type: research

Gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy in the years 2000.
CONCLUSION: The diagnostic work-up requires a multimodal approach and should be implemented (also by further studies on new biomarkers) for a prompt and individualized therapy. PMID: 27433098 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Castagnola E, Ruberto E, Guarino A Tags: World J Gastroenterol Source Type: research

Need of righteous attitudes towards eradication of hepatitis C virus infection in Latin America.
Abstract Over the last few years, we have expanded our knowledge on numerous facets of the hepatitis C virus (HCV). Beginning with its discovery and viral life cycle, its impact on health, the development of liver disease and currently, effective antiviral treatments. The latter point has become of great interest throughout the developed world, where the possible eradication of HCV through specific strategies to reach all HCV-infected people has been announced. However, this scenario is very different in the countries of Latin America (LA), in which < 2% of infected patients requiring treatment have access to HC...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Panduro A, Roman S Tags: World J Gastroenterol Source Type: research

Epidemiology of hepatitis E virus in Iran.
Abstract Iran is known as an endemic country for hepatitis E virus (HEV) infection, while there are variations in the epidemiology of HEV infection throughout the country. The available epidemiological studies in different regions of Iran show HEV seroprevalence of 1.1%-14.2% among general population, 4.5% -14.3% among blood donors, 6.1%-22.8% among injecting drug users, 6.3%-28.3% among hemodialysis patients, 1.6%-11.3% among patients infected with other hepatitis viruses, 27.5% among patients with chronic liver disease, 30.8% among kidney transplant recipient patients, and 10%-16.4% among human immunodeficiency v...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Taherkhani R, Farshadpour F Tags: World J Gastroenterol Source Type: research

Structural and molecular features of intestinal strictures in rats with Crohn's-like disease.
CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. PMID: 27298558 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Talapka P, Berkó A, Nagy LI, Chandrakumar L, Bagyánszki M, Puskás LG, Fekete É, Bódi N Tags: World J Gastroenterol Source Type: research

Apoptosis induced by a low-carbohydrate and high-protein diet in rat livers.
CONCLUSION: Eight weeks of an experimental diet resulted in cellular and histopathological lesions in rat livers. Apoptosis was our principal finding; elevated plasma transaminases demonstrate hepatic lesions. PMID: 27298559 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Monteiro ME, Xavier AR, Oliveira FL, Filho PJ, Azeredo VB Tags: World J Gastroenterol Source Type: research

Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-II expression on dendritic cells in chronic hepatitis C infection.
CONCLUSION: Underexpressed MHC class-II genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs. PMID: 27298560 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Tomer S, Chawla YK, Duseja A, Arora SK Tags: World J Gastroenterol Source Type: research

miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma.
CONCLUSION: The data obtained in the present study suggests that HBx enhances miR-106b transcription to promote tumor progression in HBV-associated HCC. PMID: 27298561 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Yen CS, Su ZR, Lee YP, Liu IT, Yen CJ Tags: World J Gastroenterol Source Type: research

Chitooligosaccharides promote radiosensitivity in colon cancer line SW480.
CONCLUSION: COS can inhibit the proliferation of SW480 cells and enhance the radiosensitization of SW480 cells, inducing apoptosis and G2/M phase arrest. PMID: 27298562 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Han FS, Yang SJ, Lin MB, Chen YQ, Yang P, Xu JM Tags: World J Gastroenterol Source Type: research

Faecalibacterium prausnitzii supernatant ameliorates dextran sulfate sodium induced colitis by regulating Th17 cell differentiation.
CONCLUSION: F. prausnitzii supernatant exerts protective and therapeutic effects on DSS-induced colitis in mice, probably via inhibition of Th17 differentiation and IL-17A secretion in the plasma and colon mucosa tissues. It can also improve colitis in mice by downregulating IL-6 and prevent colitis by upregulating IL-4. PMID: 27298563 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Huang XL, Zhang X, Fei XY, Chen ZG, Hao YP, Zhang S, Zhang MM, Yu YQ, Yu CG Tags: World J Gastroenterol Source Type: research

Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients.
CONCLUSION: The dysbiosis MS rat model and the post-inflammatory rat model captured some of the dysbiosis features of IBS patients. Fusobacterium, Clostridium XI and Porphyromonadaceae were identified as targets for future mechanistic research. PMID: 27298564 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zhou XY, Li M, Li X, Long X, Zuo XL, Hou XH, Cong YZ, Li YQ Tags: World J Gastroenterol Source Type: research

Factors affecting occurrence of gastric varioliform lesions: A case-control study.
CONCLUSION: Seven risk factors and two protective factors are determined for GVLs, which were found to be associated with premalignant abnormalities. PMID: 27298565 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zou TH, Zheng RH, Gao QY, Kong X, Chen XY, Ge ZZ, Chen YX, Zou XP, Fang JY Tags: World J Gastroenterol Source Type: research

Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study.
CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. PMID: 27298566 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Atsushi I, Mitsuyoshi O, Kazuya Y, Syuhei K, Noriyuki K, Masashi M, Akira W, Kentaro S, Nobuyuki K, Natsuko S, Jun W, Yasushi I, Chikara K, Itaru E Tags: World J Gastroenterol Source Type: research

Post-discharge complications after esophagectomy account for high readmission rates.
CONCLUSION: PDC after esophagectomy account for significant number of reoperations and readmissions. Efforts should be directed towards optimizing patient's health pre-discharge, with possible prevention programs at discharge. PMID: 27298567 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Chen SY, Molena D, Stem M, Mungo B, Lidor AO Tags: World J Gastroenterol Source Type: research

Clinical significance of HOTAIR expression in colon cancer.
CONCLUSION: HOTAIR expression is upregulated in colon cancer, suggesting that HOTAIR plays an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR may act as an oncogene and represents a new molecular target for the treatment of colon cancer. PMID: 27298568 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Luo ZF, Zhao D, Li XQ, Cui YX, Ma N, Lu CX, Liu MY, Zhou Y Tags: World J Gastroenterol Source Type: research

Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss.
CONCLUSION: Mirtazapine not only alleviates symptoms associated with dyspepsia and depression linked to FD in patients with weight loss but also significantly increases body weight (mainly the visceral fat in body fat). The likely mechanism of mirtazapine action is regulation of brain-gut or gastrointestinal hormone levels. PMID: 27298569 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Jiang SM, Jia L, Liu J, Shi MM, Xu MZ Tags: World J Gastroenterol Source Type: research

Inflammatory bowel disease: A descriptive study of 716 local Chilean patients.
CONCLUSION: IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries. PMID: 27298570 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Simian D, Fluxá D, Flores L, Lubascher J, Ibáñez P, Figueroa C, Kronberg U, Acuña R, Moreno M, Quera R Tags: World J Gastroenterol Source Type: research

Primary biliary cirrhosis degree assessment by acoustic radiation force impulse imaging and hepatic fibrosis indicators.
CONCLUSION: The diagnostic value of PBC cirrhosis degree in liver cirrhosis degree assessment by ARFI combined with the four indicators of serum liver fibrosis is of satisfactory effectiveness and has important clinical application value. PMID: 27298571 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zhang HC, Hu RF, Zhu T, Tong L, Zhang QQ Tags: World J Gastroenterol Source Type: research

Hepatitis C virus genotype 3: Meta-analysis on sustained virologic response rates with currently available treatment options.
CONCLUSION: Lastly, SOF + DCV combination is probably the best oral therapy option and the addition of RBV does not appear to be needed to increase SVR rates substantially. PMID: 27298572 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Ampuero J, Reddy KR, Romero-Gomez M Tags: World J Gastroenterol Source Type: research

Laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis for Peutz-Jeghers syndrome with synchronous rectal cancer.
This report presents a patient with a 20-year history of intermittent bloody stool, mucocutaneous pigmentation and a family history of PJS, which together led to a diagnosis of PJS. Moreover, colonoscopy and biopsy revealed the presence of multiple serried giant pedunculated polyps and rectal adenocarcinoma. Currently, few options exist for the therapeutic management of PJS with synchronous rectal cancer. For this case, we adopted an unconventional surgical strategy and ultimately performed laparoscopic restorative proctocolectomy with IPAA. This procedure is widely considered to be the first-line treatment option for pati...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zhong ME, Niu BZ, Ji WY, Wu B Tags: World J Gastroenterol Source Type: research

Application of cystoscope in surgical treatment of hepatocellular carcinoma with portal vein tumor thrombus.
Abstract Development of portal vein tumor thrombus deteriorates the prognosis of hepatocellular carcinoma, while surgical treatment can offer a promising prognosis for selected patients. However, the possibility of residual lesions in portal vein after conventional thrombectomy is a main risk factor leading to postoperative recurrence. Therefore, ensuring the complete removal of tumor thrombus during operation is critical to improve prognosis. For the first time, we report here one case of hepatocellular carcinoma with portal vein tumor thrombus in which cystoscope was successfully applied as a substitute of intrav...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Li N, Wei XB, Cheng SQ Tags: World J Gastroenterol Source Type: research

Surgical dilemmas in the management of colorectal liver metastases: The role of timing.
Abstract Colorectal cancer (CRC) is an emerging health problem in the Western World both for its raising tendency as well as for its metastatic potential. Almost half of the patients with CRC will develop liver metastases during the course of their disease. The liver surgeon dealing with colorectal liver metastases faces several surgical dilemmas especially in the setting of the timing of operation. Synchronous resectable metastases should be treated prior or after induction chemotherapy? Furthermore in the case of synchronous colorectal liver metastases which organ should we first deal with, the liver or the colon...
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Dimitroulis D, Kouraklis G Tags: World J Gastroenterol Source Type: research

How important is donor age in liver transplantation?
Abstract The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation (LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Li...
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Lué A, Solanas E, Baptista P, Lorente S, Araiz JJ, Garcia-Gil A, Serrano MT Tags: World J Gastroenterol Source Type: research

Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse.
Abstract External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy (VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of p...
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: van Iersel JJ, Paulides TJ, Verheijen PM, Lumley JW, Broeders IA, Consten EC Tags: World J Gastroenterol Source Type: research

Multiorgan chronic inflammatory hepatobiliary pancreatic murine model deficient in tumor necrosis factor receptors 1 and 2.
CONCLUSION: This is the first report of chronic inflammatory multiorgan hepatobiliary pancreatitis, along with fibrosis and calculi formation induced reliably utilizing oral DBTC administration in TNFR1/R2 deficient mice. PMID: 27275091 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Oz HS Tags: World J Gastroenterol Source Type: research

Phosalone-induced inflammation and oxidative stress in the colon: Evaluation and treatment.
CONCLUSION: This research highlights that EA is effective to alleviate the side effects of phosalone by reducing the level of oxidative stress and inflammatory proteins. PMID: 27275092 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Ghasemi-Niri SF, Maqbool F, Baeeri M, Gholami M, Abdollahi M Tags: World J Gastroenterol Source Type: research

CdSe/ZnS quantum dots induce photodynamic effects and cytotoxicity in pancreatic cancer cells.
CONCLUSION: CdSe/ZnS QDs can be used as a photosensitizer to inhibit SW1990 cell proliferation through ROS generation and apoptotic protein expression regulation. PMID: 27275093 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: He SJ, Cao J, Li YS, Yang JC, Zhou M, Qu CY, Zhang Y, Shen F, Chen Y, Li MM, Xu LM Tags: World J Gastroenterol Source Type: research

Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice.
CONCLUSION: Exogenous recombinant IL-22 protects mice against L-arginine-induced SAP-associated lung injury by enhancing the expression of anti-apoptosis genes through the STAT3 signaling pathway. PMID: 27275094 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Qiao YY, Liu XQ, Xu CQ, Zhang Z, Xu HW Tags: World J Gastroenterol Source Type: research

(125)I-labeled anti-bFGF monoclonal antibody inhibits growth of hepatocellular carcinoma.
CONCLUSION: (125)I-bFGF mAb inhibits growth of HCC xenografts. The coupling effect of (125)I-bFGF mAb is more effective than the concomitant use of (125)I and bFGF mAb. PMID: 27275095 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Hu PH, Pan LH, Wong PT, Chen WH, Yang YQ, Wang H, Xiang JJ, Xu M Tags: World J Gastroenterol Source Type: research

Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model.
CONCLUSION: Transarterial administration of integrin inhibitor loaded nanoparticles combined with TACE evidently retards tumor growth and intrahepatic metastases compared with TACE alone or TACE plus integrin inhibitor in an animal model of hepatocellular carcinoma. PMID: 27275096 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Qian J, Oppermann E, Tran A, Imlau U, Qian K, Vogl TJ Tags: World J Gastroenterol Source Type: research

Danish cohort of monozygotic inflammatory bowel disease twins: Clinical characteristics and inflammatory activity.
CONCLUSION: The presented IBD twin cohorts are an excellent resource for bioinformatics studies with proper adjustment for disease-associated exposures including medication and inflammatory activity in the co-twins. PMID: 27275097 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Moller FT, Knudsen L, Harbord M, Satsangi J, Gordon H, Christiansen L, Christensen K, Jess T, Andersen V Tags: World J Gastroenterol Source Type: research