Medicine RSS Search Engine

World Journal of Gastroenterology : WJG

This page shows you the latest items in this publication.

Hepatitis C virus in the new era: Perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Abstract Despite the great successes achieved in the fields of virology and diagnostics, several difficulties affect improvements in hepatitis C virus (HCV) infection control and eradication in the new era. New HCV infections still occur, especially in some of the poorest regions of the world, where HCV is endemic and long-term sequelae have a growing economic and health burden. An HCV vaccine is still no available, despite years of researches and discoveries about the natural history of infection and host-virus interactions: several HCV vaccine candidates have been developed in the last years, targeting different ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G Tags: World J Gastroenterol Source Type: research

Intestinal antigen-presenting cells in mucosal immune homeostasis: Crosstalk between dendritic cells, macrophages and B-cells.
We describe mechanisms of maintaining intestinal immune tolerance in the steady state but also inappropriate responses of APC to components of the gut microbiota that contribute to pathology in IBD. PMID: 25110405 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Mann ER, Li X Tags: World J Gastroenterol Source Type: research

Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis.
Abstract Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has become the surgical treatment of choice for many patients with medically refractory ulcerative colitis (UC) and familial adenomatous polyposis (FAP). UC patients with IPAA (UC-IPAA) are, nevertheless, susceptible to inflammatory and noninflammatory sequelae such as pouchitis, which is only rarely noted in FAP patients with IPAA. Pouchitis is the most frequent long-term complication of UC-IPAA patients, with a cumulative prevalence of up to 50%. Although the aetiology of pouchitis remains unclear, accumulating evidence suggests that a ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Angriman I, Scarpa M, Castagliuolo I Tags: World J Gastroenterol Source Type: research

Optimization of the treatment with immunosuppressants and biologics in inflammatory bowel disease.
Abstract Many placebo controlled trials and meta-analyses evaluated the efficacy of different drugs for the treatment of inflammatory bowel disease (IBD), including immunosuppressants and biologics. Their use is indicated in moderate to severe disease in non responders to corticosteroids and in steroid-dependent patients, as induction and maintainance treatment. Infliximab, as well as cyclosporine, is considered a second line therapy in the case of severe ulcerative colitis, or non-responders to intravenous corticosteroids. An adequate dosage and duration of therapy with thiopurines should be reached before evaluat...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Renna S, Cottone M, Orlando A Tags: World J Gastroenterol Source Type: research

Preventing infective complications in inflammatory bowel disease.
Abstract Over the past decade there has been a dramatic change in the treatment of patients with Crohn's disease and ulcerative colitis, which comprise the inflammatory bowel diseases (IBD). This is due to the increasing use of immunosuppressives and in particular the biological agents, which are being used earlier in the course of disease, and for longer durations, as these therapies result in better clinical outcomes for patients. This, however, has the potential to increase the risk of opportunistic and serious infections in these patients, most of which are preventable. Much like the risk for potential malignan...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Mill J, Lawrance IC Tags: World J Gastroenterol Source Type: research

Treating inflammatory bowel disease by adsorptive leucocytapheresis: A desire to treat without drugs.
Abstract Ulcerative colitis and Crohn's disease are the major phenotypes of the idiopathic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms, impairing function and quality of life. Current medications are aimed at reducing the symptoms or suppressing exacerbations. However, patients require life-long medications, and this can lead to drug dependency, loss of response together with adverse side effects. Indeed, drug side effects become additional morbidity factor in many patients on long-term medications. Nonetheless, the efficacy of anti-tumour...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Saniabadi AR, Tanaka T, Ohmori T, Sawada K, Yamamoto T, Hanai H Tags: World J Gastroenterol Source Type: research

Inflammatory pathways in the early steps of colorectal cancer development.
Abstract Colorectal cancer is a major cause of cancer-related death in many countries. Colorectal carcinogenesis is a stepwise process which, from normal mucosa leads to malignancy. Many factors have been shown to influence this process, however, at present, several points remain obscure. In recent years some hypotheses have been considered on the mechanisms involved in cancer development, expecially in its early stages. Tissue injury resulting from infectious, mechanical, or chemical agents may elicit a chronic immune response resulting in cellular proliferation and regeneration. Chronic inflammation of the large ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Mariani F, Sena P, Roncucci L Tags: World J Gastroenterol Source Type: research

Beyond KRAS: Predictive factors of the efficacy of anti-EGFR monoclonal antibodies in the treatment of metastatic colorectal cancer.
Abstract Systematic analysis of the epidermal growth factor receptor (EGFR) pathway revealed that biomarkers could be used to predict the response to and outcome of anti-EGFR therapies in patients affected by metastatic colorectal cancer. We have conducted a review on the most recent findings and advances on this topic. To this aim, we searched the PubMed database for articles devoted to predictive and prognostic biomarkers for patients administered cetuximab- and panitumumab-based therapies. Here we review the state of the art and the controversies about the molecular factors known to be predictors of the efficacy...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: De Stefano A, Carlomagno C Tags: World J Gastroenterol Source Type: research

p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance.
Abstract Colorectal cancer (CRC) remains one of the most common malignancies in the world. Although surgical resection combined with adjuvant therapy is effective at the early stages of the disease, resistance to conventional therapies is frequently observed in advanced stages, where treatments become ineffective. Resistance to cisplatin, irinotecan and 5-fluorouracil chemotherapy has been shown to involve mitogen-activated protein kinase (MAPK) signaling and recent studies identified p38α MAPK as a mediator of resistance to various agents in CRC patients. Studies published in the last decade showed a dual role fo...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Grossi V, Peserico A, Tezil T, Simone C Tags: World J Gastroenterol Source Type: research

Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer.
Abstract Advances in genomics, molecular pathology and metabolism have generated many candidate biomarkers of colorectal cancer with potential clinical value. Epidemiological and biological studies suggest a role for adiposity, dyslipidaemia, hyperinsulinemia, altered glucose homeostasis, and elevated expression of insulin-like growth factor (IGF) axis members in the risk and prognosis of cancer. This review discusses some recent past and current approaches being taken by researches in obesity and metabolic disorders. The authors describe three main systems as the most studied metabolic candidates of carcinogenesis...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Muc-Wierzgoń M, Nowakowska-Zajdel E, Dzięgielewska-Gęsiak S, Kokot T, Klakla K, Fatyga E, Grochowska-Niedworok E, Waniczek D, Wierzgoń J Tags: World J Gastroenterol Source Type: research

Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years.
Abstract During the past two decades the first sequencing of the human genome was performed showing its high degree of inter-individual differentiation, as a result of large international research projects (Human Genome Project, the 1000 Genomes Project International HapMap Project, and Programs for Genomic Applications NHLBI-PGA). This period was also a time of intensive development of molecular biology techniques and enormous knowledge growth in the biology of cancer. For clinical use in the treatment of patients with colorectal cancer (CRC), in addition to fluoropyrimidines, another two new cytostatic drugs were...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Panczyk M Tags: World J Gastroenterol Source Type: research

Genetic predisposition to colorectal cancer: Where we stand and future perspectives.
Abstract The development of colorectal cancer (CRC) can be influenced by genetic factors in both familial cases and sporadic cases. Familial CRC has been associated with genetic changes in high-, moderate- and low-penetrance susceptibility genes. However, despite the availability of current gene-identification techniques, the genetic causes of a considerable proportion of hereditary cases remain unknown. Genome-wide association studies of CRC have identified a number of common low-penetrance alleles associated with a slightly increased or decreased risk of CRC. The accumulation of low-risk variants may partly expla...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Valle L Tags: World J Gastroenterol Source Type: research

Controversies in the pathological assessment of colorectal cancer.
Abstract Pathologic assessment of colorectal cancer specimens plays an essential role in patient management, informing prognosis and contributing to therapeutic decision making. The tumor-node-metastasis (TNM) staging system is a key component of the colorectal cancer pathology report and provides important prognostic information. However there is significant variation in outcome of patients within the same tumor stage. Many other histological features such as tumor budding, vascular invasion, perineural invasion, tumor grade and rectal tumor regression grade that may be of prognostic value are not part of TNM stag...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Maguire A, Sheahan K Tags: World J Gastroenterol Source Type: research

Strategies to overcome resistance to epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer.
Abstract Administration of monoclonal antibodies (mAbs) against epidermal growth factor receptor (EGFR) such as cetuximab and panitumumab in combination with conventional chemotherapy substantially prolongs survival of patients with metastatic colorectal cancer (mCRC). However, the efficacy of these mAbs is limited due to genetic variation among patients, in particular K-ras mutations. The discovery of K-ras mutation as a predictor of non-responsiveness to EGFR mAb therapy has caused a major change in the treatment of mCRC. Drugs that inhibit transformation caused by oncogenic alterations of Ras and its downstream ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Jeong WJ, Cha PH, Choi KY Tags: World J Gastroenterol Source Type: research

Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis.
Abstract Patients with inflammatory bowel disease (IBD) are at increased risk for developing colorectal cancer (CRC), although the overall incidence of IBD-associated CRC has been diminishing in recent decades in western countries. As demonstrated in previous studies, the risk of CRC in IBD increases with longer duration, extent of colitis, a familial history of CRC, coexistent primary sclerosing cholangitis, and the degree of inflammation. The pathogenesis of CRC in IBD is poorly understood. Similar to sporadic CRC, IBD-associated CRC is a consequence of sequential episodes of genomic alteration. Multiple inter-re...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Kim ER, Chang DK Tags: World J Gastroenterol Source Type: research

Structural modifications of Helicobacter pylori lipopolysaccharide: An idea for how to live in peace.
Abstract In this review, we discuss the findings and concepts underlying the "persistence mechanisms" of Helicobacter pylori (H. pylori), a spiral-shaped, Gram-negative rod bacterium that was discovered as a gastric pathogen by Marshall and Warren in 1984. H. pylori colonizes the gastric mucosa of nearly half of the human population. Infections appear in early childhood and, if not treated, persist for life. The presence or absence of symptoms and their severity depend on multiple bacterial components, host susceptibility and environmental factors, which allow H. pylori to switch between pathogenicity and commensal...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Chmiela M, Miszczyk E, Rudnicka K Tags: World J Gastroenterol Source Type: research

Treatment of Helicobacter pylori infection: Meeting the challenge of antimicrobial resistance.
Abstract Treatment of Helicobacter pylori (H. pylori) infection is paramount for the management of prevalent gastrointestinal disorders including peptic ulcer disease and gastric cancer. Due to the wide increase in prevalence of H. pylori resistance to antibiotics, clarithromycin-based triple therapies are not any more suitable for unconditional empiric use, and should not be recommended, unless local resistance to this antibiotic is low (< 20%). Alternative strategies have been proposed to overcome the issue of increasing clarithromycin resistance, and some of them are already implemented in clinical practice. ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Papastergiou V, Georgopoulos SD, Karatapanis S Tags: World J Gastroenterol Source Type: research

Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance.
Abstract The gram-negative bacterium Helicobacter pylori (H. pylori) causes chronic gastritis, gastric and duodenal ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma. Treatment is recommended in all symptomatic patients. The current treatment options for H. pylori infection are outlined in this review in light of the recent challenges in eradication success, largely due to the rapid emergence of antibiotic resistant strains of H. pylori. Antibiotic resistance is a constantly evolving process and numerous studies have shown that the prevalence of H. pylori antibiotic resistance varies significant...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Smith SM, O'Morain C, McNamara D Tags: World J Gastroenterol Source Type: research

Helicobacter pylori and oral pathology: Relationship with the gastric infection.
Abstract Helicobacter pylori (H. pylori) has been found in the oral cavity and stomach, and its infection is one of the most frequent worldwide. We reviewed the literature and conducted a Topic Highlight, which identified studies reporting an association between H. pylori-infection in the oral cavity and H. pylori-positive stomach bacterium. This work was designed to determine whether H. pylori is the etiologic agent in periodontal disease, recurrent aphthous stomatitis (RAS), squamous cell carcinoma, burning and halitosis. Record selection focused on the highest quality studies and meta-analyses. We selected 48 ar...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Adler I, Muiño A, Aguas S, Harada L, Diaz M, Lence A, Labbrozzi M, Muiño JM, Elsner B, Avagnina A, Denninghoff V Tags: World J Gastroenterol Source Type: research

Surgical management of peritonitis secondary to acute superior mesenteric artery occlusion.
Abstract Diagnosis of acute arterial mesenteric ischemia in the early stages is now possible using modern computed tomography with intravenous contrast enhancement and imaging in the arterial and/or portal phase. Most patients have acute superior mesenteric artery (SMA) occlusion, and a large proportion of these patients will develop peritonitis prior to mesenteric revascularization, and explorative laparotomy will therefore be necessary to evaluate the extent and severity of intestinal ischemia, and to perform bowel resections. The establishment of a hybrid operating room in vascular units in hospitals is most imp...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Acosta S Tags: World J Gastroenterol Source Type: research

Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance.
Abstract Autism spectrum disorders (ASD) comprise a group of neurodevelopmental abnormalities that begin in early childhood and are characterized by impairment of social communication and behavioral problems including restricted interests and repetitive behaviors. Several genes have been implicated in the pathogenesis of ASD, most of them are involved in neuronal synaptogenesis. A number of environmental factors and associated conditions such as gastrointestinal (GI) abnormalities and immune imbalance have been linked to the pathophysiology of ASD. According to the March 2012 report released by United States Center...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Samsam M, Ahangari R, Naser SA Tags: World J Gastroenterol Source Type: research

Therapeutic uses of animal biles in traditional Chinese medicine: An ethnopharmacological, biophysical chemical and medicinal review.
We present an informed opinion of the clinical efficacy of the medicinal uses of the different animal biles based on their presently known principal chemical components which are mostly steroidal detergent-like molecules and the membrane lipids such as unesterified cholesterol and mixed phosphatidylcholines and sometimes sphingomyelin, as well as containing lipopigments derived from heme principally bilirubin glucuronides. All of the available information on the ethnopharmacological uses of biles in TCM were collated from the rich collection of ancient Chinese books on materia medica held in libraries in China and United S...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Wang DQ, Carey MC Tags: World J Gastroenterol Source Type: research

Endoscopic ultrasound in the diagnosis and treatment of pancreatic disease.
Abstract Endoscopic ultrasound (EUS) is an important part of modern gastrointestinal endoscopy and now has an integral role in the diagnostic evaluation of pancreatic diseases. Furthermore, as EUS technology has advanced, it has increasingly become a therapeutic procedure, and the prospect of multiple applications of interventional EUS for the pancreas is truly on the near horizon. However, this review focuses on the established diagnostic and therapeutic roles of EUS that are used in current clinical practice. In particular, the diagnostic evaluation of acute pancreatitis, chronic pancreatitis, cystic pancreatic l...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Teshima CW, Sandha GS Tags: World J Gastroenterol Source Type: research

Spontaneous free perforation of the small intestine in adults.
Abstract Spontaneous free perforation of the small intestine is uncommon, especially if there is no prior history of visceral trauma. However, free, even recurrent, perforation may complicate a defined and established clinical disorder, such as Crohn's disease. In addition, free perforation may be the initial clinical presentation of an occult intestinal disorder, such as a lymphoma complicating celiac disease, causing diffuse peritonitis and an acute abdomen. Initial diagnosis of the precise cause may be difficult, but now has been aided by computerized tomographic imaging. The site of perforation may be helpful i...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Freeman HJ Tags: World J Gastroenterol Source Type: research

Liver metastases: Contrast-enhanced ultrasound compared with computed tomography and magnetic resonance.
Abstract The development of ultrasound contrast agents with excellent tolerance and safety profiles has notably improved liver evaluation with ultrasound (US) for several applications, especially for the detection of metastases. In particular, contrast enhanced ultrasonography (CEUS) allows the display of the parenchymal microvasculature, enabling the study and visualization of the enhancement patterns of liver lesions in real time and in a continuous manner in all vascular phases, which is similar to contrast-enhanced computed tomography (CT) and contrast-enhanced magnetic resonance imaging. Clinical studies have ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Cantisani V, Grazhdani H, Fioravanti C, Rosignuolo M, Calliada F, Messineo D, Bernieri MG, Redler A, Catalano C, D'Ambrosio F Tags: World J Gastroenterol Source Type: research

Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas.
The objective of this review is to identify the molecular characteristics of IPMNs in order to recognize potential markers for the discrimination of more aggressive IPMNs requiring surgical resection from benign IPMNs that could be observed. We briefly summarize recent research findings on the genetics and epigenetics of intraductal papillary mucinous neoplasms, identifying some genes, molecular mechanisms and cellular signaling pathways correlated to the pathogenesis of IPMNs and their progression to malignancy. The knowledge of molecular biology of IPMNs has impressively developed over the last few years. A great amount ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Paini M, Crippa S, Partelli S, Scopelliti F, Tamburrino D, Baldoni A, Falconi M Tags: World J Gastroenterol Source Type: research

Capsule endoscopy: Present status and future expectation.
Abstract Video capsule endoscopy (CE) since its introduction 13 years back, has revolutionized our approach to small intestinal diseases. Obscure gastrointestinal bleed (OGIB) continues to be the most important indication for CE with a high sensitivity, specificity as well as positive and negative predictive values. It is best performed during ongoing bleed or immediately thereafter. Overt OGIB has a higher diagnostic yield than occult OGIB. However, even in iron deficiency anemia, CE is emerging as important investigation after initial negative work up. In suspected Crohn's disease (CD), CE has been shown superior...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Goenka MK, Majumder S, Goenka U Tags: World J Gastroenterol Source Type: research

Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells.
CONCLUSION: Aspirin demonstrates promising anticancer properties for NETs in vitro. Further preclinical and clinical studies are needed. PMID: 25110431 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Spampatti M, Vlotides G, Spöttl G, Maurer J, Göke B, Auernhammer CJ Tags: World J Gastroenterol Source Type: research

IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.
CONCLUSION: IGF2 DMR0 hypomethylation may be an infrequent epigenetic alteration in the SSA pathway. Hypomethylation of IGF2 DMR0 and LINE-1 may play a role in TSA pathway progression. PMID: 25110432 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y Tags: World J Gastroenterol Source Type: research

CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation.
CONCLUSION: CacyBP/SIP nuclear translocation promotes the proliferation and cell cycle progression of gastric cancer cells. PMID: 25110433 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Zhai HH, Meng J, Wang JB, Liu ZX, Li YF, Feng SS Tags: World J Gastroenterol Source Type: research

KISS1 methylation and expression as predictors of disease progression in colorectal cancer patients.
CONCLUSION: These data suggest that KISS1 is down-regulated in cancer tissues via promoter hypermethylation and therefore may represent a candidate target for treating metastatic CRC. PMID: 25110434 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Chen SQ, Chen ZH, Lin SY, Dai QB, Fu LX, Chen RQ Tags: World J Gastroenterol Source Type: research

Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression.
CONCLUSION: These findings demonstrate that DHM inhibits the migration and invasion of hepatoma cells and may serve as a potential candidate agent for the prevention of HCC metastasis. PMID: 25110435 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Zhang QY, Li R, Zeng GF, Liu B, Liu J, Shu Y, Liu ZK, Qiu ZD, Wang DJ, Miao HL, Li MY, Zhu RZ Tags: World J Gastroenterol Source Type: research

RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer.
CONCLUSION: These data suggest that RAD51 potentiates the synergistic effects of chemotherapy with PCI-24781 and CDDP on GC. PMID: 25110436 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: He WL, Li YH, Hou WJ, Ke ZF, Chen XL, Lu LY, Cai SR, Song W, Zhang CH, He YL Tags: World J Gastroenterol Source Type: research

Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease.
CONCLUSION: The PLALA score may be an ideal scoring system for detecting cirrhosis in NAFLD patients with sufficient accuracy and simplicity to be considered for clinical use. PMID: 25110437 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Kessoku T, Ogawa Y, Yoneda M, Imajo K, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Chayama K, Tanaka S, Fujimoto K, Anzai K, Saibara T, Sata M, Itoh Y, Nakajima A, Jsg-Nafld TO Tags: World J Gastroenterol Source Type: research

Surgical management of colonic diverticular disease: Discrepancy between right- and left-sided diseases.
CONCLUSION: Compared with right-sided diverticular disease, the incidence of left-sided disease in Korea has increased since 2001 and is associated with worse surgical outcomes. PMID: 25110438 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Oh HK, Han EC, Ha HK, Choe EK, Moon SH, Ryoo SB, Jeong SY, Park KJ Tags: World J Gastroenterol Source Type: research

Using cholecystokinin to facilitate endoscopic clearance of large common bile duct stones.
CONCLUSION: CCK during ESWL can aid with the clearance of CBD stones in the first ESWL/ERCP session. Mechanical lithotripsy usage was reduced and the extremely large stone (≥ 30 mm) clearance rate can be raised. PMID: 25110439 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Tao T, Zhang QJ, Zhang M, Zhu X, Sun SX, Li YQ Tags: World J Gastroenterol Source Type: research

Physical activity support or weight loss counseling for nonalcoholic fatty liver disease?
CONCLUSION: Intensive psychological counseling for PA produces hepatic effects not different from standard CBT, improving physical fitness and liver fat independent of weight loss. Strategies promoting exercise are worth and effective in motivated patients, particularly in lean NAFLD patients where large weight loss cannot be systematically pursued. PMID: 25110440 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Montesi L, Caselli C, Centis E, Nuccitelli C, Moscatiello S, Suppini A, Marchesini G Tags: World J Gastroenterol Source Type: research

Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas: 10 year single-center experience and literature review.
CONCLUSION: Our series shows how multimodal management of Hbl, exhaustive control and a meticulous surgical approach leads to almost 100% complete resection with optimal postoperative results. PMID: 25110441 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Ayllon Teran D, Gómez Beltran O, Ciria Bru R, Mateos González E, Peña Rosa MJ, Luque Molina A, López Cillero P, Briceño Delgado J Tags: World J Gastroenterol Source Type: research

Trends in incidence and management of cancer of the ampulla of Vater.
CONCLUSION: Cancer of the ampulla of Vater is still uncommon, but its incidence increased for men in Burgundy. Diagnosis is often made at an advanced stage, dramatically worsening the prognosis. PMID: 25110442 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Rostain F, Hamza S, Drouillard A, Faivre J, Bouvier AM, Lepage C Tags: World J Gastroenterol Source Type: research

Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?
CONCLUSION: 100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis. PMID: 25110443 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Döbrönte Z, Szepes Z, Izbéki F, Gervain J, Lakatos L, Pécsi G, Ihász M, Lakner L, Toldy E, Czakó L Tags: World J Gastroenterol Source Type: research

Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats.
CONCLUSION: MTX-induced structural and functional damage to hepatic tissues in rats may involve oxidative stress, and cytoprotective agents (NAC > AMF > ASC) may alleviate MTX hepatotoxicity. PMID: 25110444 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, Erdemli E, Turkoz Y Tags: World J Gastroenterol Source Type: research

Pouch size influences clinical outcome of pouch construction after total gastrectomy: A meta-analysis.
CONCLUSION: Small pouch can significantly improve the eating capacity per meal after surgery, and may improve the post-gastrectomy symptoms, including heartburn, dysphagia and vomiting. PMID: 25110445 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Dong HL, Huang YB, Ding XW, Song FJ, Chen KX, Hao XS Tags: World J Gastroenterol Source Type: research

Clinical outcome of small hepatocellular carcinoma after different treatments: A meta-analysis.
CONCLUSION: Surgical resection is superior to nonsurgical ablation for the treatment of small HCC. Among the studies analyzed, RFA is the most efficacious single nonsurgical ablation treatment. PMID: 25110446 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Dong W, Zhang T, Wang ZG, Liu H Tags: World J Gastroenterol Source Type: research

Transthoracic vs transhiatal surgery for cancer of the esophagogastric junction: A meta-analysis.
CONCLUSION: The transhiatal approach for cancers of the esophagogastric junction, especially types III, should be recommended, and its long-term outcome benefits should be further evaluated. PMID: 25110447 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Wei MT, Zhang YC, Deng XB, Yang TH, He YZ, Wang ZQ Tags: World J Gastroenterol Source Type: research

Fever as a first manifestation of advanced gastric adenosquamous carcinoma: A case report.
We describe a case of a 73-year-old male, who presented with refractory fever and an intra-abdominal mass on imaging. He underwent a laparoscopic exploration followed by a successful totally laparoscopic total gastrectomy with D2 lymphadenectomy for gastric cancer. Postoperative pathology revealed primary gastric ASC (T4aN0M0). The patient received adjuvant radiotherapy and chemotherapy with S1 and is alive 20 mo after surgery without recurrence. This is the first case of advanced gastric ASC with fever as the initial presentation treated with totally laparoscopic total gastrectomy reported in the English literature. ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Ajoodhea H, Zhang RC, Xu XW, Jin WW, Chen K, He YT, Mou YP Tags: World J Gastroenterol Source Type: research

Imaging findings of primary gastric plasmacytoma: A case report.
Abstract Primary gastric plasmacytoma (GP) is a rare extramedullary plasmacytoma with clinical and imaging features that are common among other gastric tumors, such as gastric adenocarcinomas, gastric stromal tumors, and lymphomas. Here, we present a histologically confirmed case of primary GP examined with biphasic computed tomography (CT), magnetic resonance imaging (MRI), and endosonography. A well-circumscribed extraluminal mass appearing as homogeneous attenuation/intensity with gradual enhancement was identified on biphasic enhancement CT and MRI. This mass was hyperintense on diffusion-weighted imaging and ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Zhao ZH, Yang JF, Wang JD, Wei JG, Liu F, Wang BY Tags: World J Gastroenterol Source Type: research

Little girl who conquered the "ALPPS''.
Abstract An insufficient future liver remnant (FLR) is associated with post-hepatectomy liver failure. Associating liver partition and portal vein ligation for stage hepatectomy (ALPPS) has been shown to be effective for the induction of rapid FLR hypertrophy so as to improve the resectability in patients with insufficient FLR. We hereby report our experience of this novel approach for a 6-year-old patient with hepatoblastoma. Computed tomography showed a hepatoblastoma measuring 12.5 cm × 9.9 cm × 11.7 cm in the right liver (Couinaud segment IV, V and VIII). Volumetric assessment of the FLR i.e., left lateral se...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Chan A, Chung PH, Poon RT Tags: World J Gastroenterol Source Type: research

E2F transcription factors and digestive system malignancies: How much do we know?
Abstract The E2F proteins comprise a family of 8 members that function as transcription factors. They are key targets of the retinoblastoma protein (RB) and were initially divided into groups of activators and repressors. Accumulating data suggest that there is no specific role for each individual E2F member. Instead, each E2F can exert a variety of cellular effects, some of which represent opposing ones. For instance, specific E2Fs can activate transcription and repression, promote or hamper cell proliferation, augment or inhibit apoptosis, all being dependent on the cellular context. This complexity reflects the ...
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Evangelou K, Havaki S, Kotsinas A Tags: World J Gastroenterol Source Type: research

Cannulation of the intradiverticular papilla using a duodenoscope: Is it a safe method?
Abstract Endoscopic cannulation of the biliary tract is a challenging technique in cases of periampullary diverticula. Many new devices and new manipulations for successful biliary cannulation have been reported. Endoscopy used to locate and cannulate a papilla hidden within a duodenal diverticulum is an effective method. However, the question of which endoscope should be chosen for this procedure, duodenoscope or gastroscope, waits to be answered. PMID: 25110452 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Qian Y, Huang J, Zhang Y, Fan ZN Tags: World J Gastroenterol Source Type: research

Could metabolic syndrome lead to hepatocarcinoma via non-alcoholic fatty liver disease?
Abstract It was estimated that from 2002 to 2008 the risk of developing cancer increased a quarter-fold in men and two-fold in women due to excessive BMI. Obesity, metabolic syndrome and type 2 diabetes mellitus are strictly related and are key pathogenetic factors of non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease worldwide. The most important consequence of the "metabolic epidemics" is the probable rise in the incidence of hepatocarcinoma (HCC), and NAFLD is the major causative factor. Adipose tissue is not merely a storage organ where lipids are preserved as an energy source. It is an ...
Source: World Journal of Gastroenterology : WJG - July 28, 2014 Category: Gastroenterology Authors: Scalera A, Tarantino G Tags: World J Gastroenterol Source Type: research