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Medical management of gastric cancer: A 2014 update.
Abstract Gastric cancer represents a serious health problem on a global scale. It is the second leading cause of cancer-related death worldwide. Novel therapeutic targets are desperately needed because the meager improvement in the cure rate of about 10% realized by adjunctive treatments to surgery is unacceptable as > 50% patients with localized gastric cancer succumb to their disease. Either postoperative chemoradiotherapy (United States), pre-and post-operative chemotherapy (Europe), and adjuvant chemotherapy after a D2 resection (Asia) can all be regarded as standards of care in the localized gastric cancer ...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Elimova E, Shiozaki H, Wadhwa R, Sudo K, Chen Q, Estrella JS, Blum MA, Badgwell B, Das P, Song S, Ajani JA Tags: World J Gastroenterol Source Type: research

Proteomic and metabolic prediction of response to therapy in gastric cancer.
Abstract Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer, the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general, but not all patients are responders. The application of targeted therapies and multimodal treatment has improve...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Aichler M, Luber B, Lordick F, Walch A Tags: World J Gastroenterol Source Type: research

MicroRNAs: Promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential.
Abstract Gastric cancer (GC) is the fourth most common cancer worldwide and ranks second in global cancer mortality statistics. Perioperative chemotherapy plays an important role in the management and treatment of advanced stage disease. However, response to chemotherapy varies widely, with some patients presenting no or only minor response to treatment. Hence, chemotherapy resistance is a major clinical problem that impacts on outcome. Unfortunately, to date there are no reliable biomarkers available that predict response to chemotherapy before the start of the treatment, or that allow modification of chemotherapy...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Matuszcak C, Haier J, Hummel R, Lindner K Tags: World J Gastroenterol Source Type: research

Subtotal gastrectomy for gastric cancer.
Abstract Although a steady decline in the incidence and mortality rates of gastric carcinoma has been observed in the last century worldwide, the absolute number of new cases/year is increasing because of the aging of the population. So far, surgical resection with curative intent has been the only treatment providing hope for cure; therefore, gastric cancer surgery has become a specialized field in digestive surgery. Gastrectomy with lymph node (LN) dissection for cancer patients remains a challenging procedure which requires skilled, well-trained surgeons who are very familiar with the fast-evolving oncological p...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Santoro R, Ettorre GM, Santoro E Tags: World J Gastroenterol Source Type: research

Screening for and surveillance of gastric cancer.
Abstract Although the prevalence of gastric cancer (GC) progressively decreased during the last decades, due to improved dietary habit, introduction of food refrigeration and recovered socio-economic level, it still accounts for 10% of the total cancer-related deaths. The best strategy to reduce the mortality for GC is to schedule appropriate screening and surveillance programs, that rises many relevant concerns taking into account its worldwide variability, natural history, diagnostic tools, therapeutic strategies, and cost-effectiveness. Intestinal-type, the most frequent GC histotype, develops through a multiste...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Compare D, Rocco A, Nardone G Tags: World J Gastroenterol Source Type: research

Improving the outcomes in gastric cancer surgery.
In conclusion, progress has been made in improving the surgical treatment of gastric cancer. However, gastric cancer treatment is high risk surgery and many areas for future research remain. PMID: 25320507 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Tegels JJ, De Maat MF, Hulsewé KW, Hoofwijk AG, Stoot JH Tags: World J Gastroenterol Source Type: research

Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells.
In conclusion, there is strong evidence that PFKFB-4 and PFKFB-3 isoenzymes are induced under hypoxia in pancreatic and other cancer cell lines, are overexpressed in gastric, colon, lung, and breast malignant tumors and undergo changes in their metabolism that contribute to the proliferation and survival of cancer cells. Thus, targeting these PFKFB may therefore present new therapeutic opportunities. PMID: 25320508 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Minchenko OH, Tsuchihara K, Minchenko DO, Bikfalvi A, Esumi H Tags: World J Gastroenterol Source Type: research

Adjuvant therapy for gastric cancer: Current and future directions.
Abstract The management of gastric cancer continues to evolve. Whilst surgery alone is effective when tumours present early, a large proportion of patients are diagnosed with loco-regionally advanced disease, resulting in high loco-regional and distant relapse rates, with subsequent poor survival. Early attempts at improving outcomes following resection were disappointing; however, randomized trials have now established either post-operative chemoradiotherapy (INT0116) or peri-operative chemotherapy as standard adjuvant therapies in the Western world. There remain, however, significant differences in the approach t...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Foo M, Leong T Tags: World J Gastroenterol Source Type: research

Clinical significance of molecular diagnosis for gastric cancer lymph node micrometastasis.
Abstract Advances in molecular diagnostic tools have allowed the identification of lymph node micrometastasis (LNM), including isolated tumor cells, in cancer patients. While immunohistochemistry and reverse transcription-polymerase chain reaction have been used to identify LNM in patients with gastric cancer, the clinical significance of this finding remains unclear. Recently, minimally invasive treatments, such as endoscopic submucosal dissection and laparoscopic surgery, are widely performed to help improve postsurgical quality of life (QOL). However, it is important to maintain the balance between QOL and curab...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Sonoda H, Tani T Tags: World J Gastroenterol Source Type: research

Gastric cancer arising from the remnant stomach after distal gastrectomy: A review.
Abstract Gastric stump carcinoma was initially reported by Balfore in 1922, and many reports of this disease have since been published. We herein review previous reports of gastric stump carcinoma with respect to epidemiology, carcinogenesis, Helicobacter pylori (H. pylori) infection, Epstein-Barr virus infection, clinicopathologic characteristics and endoscopic treatment. In particular, it is noteworthy that no prognostic differences are observed between gastric stump carcinoma and primary upper third gastric cancer. In addition, endoscopic submucosal dissection has recently been used to treat gastric stump carcin...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Takeno S, Hashimoto T, Maki K, Shibata R, Shiwaku H, Yamana I, Yamashita R, Yamashita Y Tags: World J Gastroenterol Source Type: research

Molecular targeting to treat gastric cancer.
Abstract Trastuzumab that targets human epidermal growth factor receptor 2 (HER2) protein is the only approved molecular targeting agent for treating gastric cancer in Japan and the outcomes have been favorable. However, trastuzumab is effective for only 10% to 20% of the population with gastric cancer that expresses HER2 protein. Molecular targeting therapy with bevacizumab against vascular endothelial growth factors (VEGF) and with cetuximab and panitumumab against the epidermal growth factors pathway that have been approved for treating colorectal cancer are not considered effective for treating gastric cancer a...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Aoyagi K, Kouhuji K, Kizaki J, Isobe T, Hashimoto K, Shirouzu K Tags: World J Gastroenterol Source Type: research

Rho/ROCK signaling in motility and metastasis of gastric cancer.
Abstract Gastric cancer is one of the most frequent and lethal malignancies worldwide because of high frequency of metastasis. Tumor cell motility and invasion play fundamental roles in cancer metastasis. Recent studies have revealed that the Rho/Rho-associated protein kinases (ROCK) pathway plays a critical role in the regulation of cancer cell motility and invasion. In addition, the Rho/ROCK pathway plays important roles in invasion and metastasis on the basis of its predominant function of cell cytoskeletal regulation in gastric cancer. According to the current understanding of tumor motility, there are two mode...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Matsuoka T, Yashiro M Tags: World J Gastroenterol Source Type: research

Current issues and future perspectives of gastric cancer screening.
Abstract Gastric cancer remains the second leading cause of cancer death worldwide. About half of the incidence of gastric cancer is observed in East Asian countries, which show a higher mortality than other countries. The effectiveness of 3 new gastric cancer screening techniques, namely, upper gastrointestinal endoscopy, serological testing, and "screen and treat" method were extensively reviewed. Moreover, the phases of development for cancer screening were analyzed on the basis of the biomarker development road map. Several observational studies have reported the effectiveness of endoscopic screening in reducin...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Hamashima C Tags: World J Gastroenterol Source Type: research

Is endoscopic ultrasonography still the modality of choice in preoperative staging of gastric cancer?
Abstract The treatment option for gastric cancer is usually based on preoperative staging by imaging modalities. Endoscopic ultrasonography (EUS) and computed tomography (CT) have been used as the diagnostic modality of choice in preoperative staging of gastric cancer. Magnetic resonance imaging (MRI) has been employed in several studies, and ((18)F) 2-Fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) has emerged as a new promising imaging modality. The purpose of this article is to provide summarized information on preoperative staging using EUS, multi-detector row CT (MDCT), MRI and PET for gastric c...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Hwang SW, Lee DH Tags: World J Gastroenterol Source Type: research

New approaches to gastric cancer staging: Beyond endoscopic ultrasound, computed tomography and positron emission tomography.
Abstract Currently, there is no single gold standard modality for staging of gastric cancer and several methods have been used complementarily in the each clinical situation. To make up for the shortcomings of conventional modalities such as endoscopic ultrasound, computed tomography and (18)F-fluoro-2-deoxyglucose positron emission tomography, numerous attempts with new approaches have been made for gastric cancer staging. For T staging, magnifying endoscopy with narrow-band was evaluated to differentiate mucosal cancer from submucosal cancer. Single/double contrast-enhanced ultrasound and diffusion-weighted magne...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Yoon H, Lee DH Tags: World J Gastroenterol Source Type: research

Potential prognostic, diagnostic and therapeutic markers for human gastric cancer.
Abstract The high incidence of gastric cancer (GC) and its consequent mortality rate severely threaten human health. GC is frequently not diagnosed until a relatively advanced stage. Surgery is the only potentially curative treatment. Thus, early screening and diagnosis are critical for improving prognoses in patients with GC. Gastroscopy with biopsy is an appropriate method capable of aiding the diagnosis of specific early GC tumor types; however, the stress caused by this method together with it being excessively expensive makes it difficult to use it as a routine method for screening for GC on a population basis...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Tsai MM, Wang CS, Tsai CY, Chi HC, Tseng YH, Lin KH Tags: World J Gastroenterol Source Type: research

Pathogenetic mechanisms in gastric cancer.
Abstract Gastric cancer (GC) is a major public health issue as the fourth most common cancer and the second leading cause of cancer-related death. Recent advances have improved our understanding of its molecular pathogenesis, as best exemplified by elucidating the fundamental role of several major signaling pathways and related molecular derangements. Central to these mechanisms are the genetic and epigenetic alterations in these signaling pathways, such as gene mutations, copy number variants, aberrant gene methylation and histone modification, nucleosome positioning, and microRNAs. Some of these genetic/epigeneti...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Shi J, Qu YP, Hou P Tags: World J Gastroenterol Source Type: research

Virtual gastrointestinal colonoscopy in combination with large bowel endoscopy: Clinical application.
This article reviews kinds of presentative imaging procedures for various screening options and updates detecting, staging and re-staging of CRC patients for determining the optimal therapeutic method and forecasting the risk of CRC recurrence and the overall prognosis. The combination use of virtual colonoscopy and conventional endoscopy, advantages and limitations of these modalities are also discussed. PMID: 25320519 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: He Q, Rao T, Guan YS Tags: World J Gastroenterol Source Type: research

Pathology of pancreatic ductal adenocarcinoma: Facts, challenges and future developments.
Abstract Despite major improvements concerning its diagnosis and treatment, pancreatic ductal adenocarcinoma (PDAC) remains an aggressive disease with an extremely poor prognosis. Pathology, as interface discipline between basic and clinical medicine, has substantially contributed to the recent developments and has laid the basis for further progress. The definition and classification of precursor lesions of PDAC and their molecular characterization is a fundamental step for the potential identification of biomarkers and the development of imaging methods for early detection. In addition, by integrating findings in...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Esposito I, Konukiewitz B, Schlitter AM, Klöppel G Tags: World J Gastroenterol Source Type: research

Gastric cancer: Prevention, screening and early diagnosis.
Abstract Gastric cancer continues to be an important healthcare problem from a global perspective. Most of the cases in the Western world are diagnosed at late stages when the treatment is largely ineffective. Helicobacter pylori (H. pylori) infection is a well-established carcinogen for gastric cancer. While lifestyle factors are important, the efficacy of interventions in their modification, as in the use of antioxidant supplements, is unconvincing. No organized screening programs can be found outside Asia (Japan and South Korea). Although several screening approaches have been proposed, including indirect atroph...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Pasechnikov V, Chukov S, Fedorov E, Kikuste I, Leja M Tags: World J Gastroenterol Source Type: research

Inflammatory bowel disease and thromboembolism.
Abstract Patients with inflammatory bowel disease (IBD) have an increased risk of vascular complications. Thromboembolic complications, both venous and arterial, are serious extraintestinal manifestations complicating the course of IBD and can lead to significant morbidity and mortality. Patients with IBD are more prone to thromboembolic complications and IBD per se is a risk factor for thromboembolic disease. Data suggest that thrombosis is a specific feature of IBD that can be involved in both the occurrence of thromboembolic events and the pathogenesis of the disease. The exact etiology for this special associat...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Zezos P, Kouklakis G, Saibil F Tags: World J Gastroenterol Source Type: research

Treatment of severe acute pancreatitis and its complications.
Abstract Severe acute pancreatitis (SAP), which is the most serious type of this disorder, is associated with high morbidity and mortality. SAP runs a biphasic course. During the first 1-2 wk, a pro-inflammatory response results in systemic inflammatory response syndrome (SIRS). If the SIRS is severe, it can lead to early multisystem organ failure (MOF). After the first 1-2 wk, a transition from a pro-inflammatory response to an anti-inflammatory response occurs; during this transition, the patient is at risk for intestinal flora translocation and the development of secondary infection of the necrotic tissue, which...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Zerem E Tags: World J Gastroenterol Source Type: research

Update on surgical treatment of pancreatic neuroendocrine neoplasms.
Abstract Pancreatic neuroendocrine neoplasms (PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential (neurendocrine tumors PNETs) or overt (neuroendocrine carcinomas PNECs) malignant, but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimally-invasive approaches which should be tailored to the individual patient. Generally, surgeons must aim for parenchyma sparing in these cases...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: D'Haese JG, Tosolini C, Ceyhan GO, Kong B, Esposito I, Michalski CW, Kleeff J Tags: World J Gastroenterol Source Type: research

Epithelial cysts of the spleen: A minireview.
Abstract Primary splenic epithelial cyst is an unusual event in everyday surgical practice with about 800 cases reported until date in the English literature. Splenic cysts may be parasitic or non-parasitic in origin. Nonparasitic cysts are either primary or secondary. Primary cysts are also called true, congenital, epidermoid or epithelial cysts. Primary splenic cysts account for 10% of all benign non-parasitic splenic cysts and are the most frequent type of splenic cysts in children. Usually, splenic cysts are asymptomatic and can be found incidentally during imaging techniques or on laprotomy. The symptoms are r...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Ingle SB, Hinge Ingle CR, Patrike S Tags: World J Gastroenterol Source Type: research

Gastric leaks post sleeve gastrectomy: Review of its prevention and management.
Abstract Gastric sleeve gastrectomy has become a frequent bariatric procedure. Its apparent simplicity hides a number of serious, sometimes fatal, complications. This is more important in the absence of an internationally adopted algorithm for the management of the leaks complicating this operation. The debates exist even regarding the definition of a leak, with several classification systems that can be used to predict the cause of the leak, and also to determine the treatment plan. Causes of leak are classified as mechanical, technical and ischemic causes. After defining the possible causes, authors went into sug...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Abou Rached A, Basile M, El Masri H Tags: World J Gastroenterol Source Type: research

Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob).
CONCLUSION: Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir, ChAT-ir and CalR-ir myenteric neurons. PMID: 25320527 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Mizuno MS, Crisma AR, Borelli P, Schäfer BT, Silveira MP, Castelucci P Tags: World J Gastroenterol Source Type: research

Real time shear wave elastography in chronic liver diseases: Accuracy for predicting liver fibrosis, in comparison with serum markers.
CONCLUSION: SWE showed a significant correlation with the severity of liver fibrosis and was useful and accurate to predict significant and advanced fibrosis, comparable with serum markers. PMID: 25320528 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Jeong JY, Kim TY, Sohn JH, Kim Y, Jeong WK, Oh YH, Yoo KS Tags: World J Gastroenterol Source Type: research

Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients.
CONCLUSION: Infection and high neutrophil counts are associated with a poorer cancer-specific survival in colorectal cancer patients. PMID: 25320529 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Attiê R, Chinen LT, Yoshioka EM, Silva MC, de Lima VC Tags: World J Gastroenterol Source Type: research

Endoscopic stenting for recurrence-related colorectal anastomotic site obstruction: Preliminary experience.
CONCLUSION: SEMS placement is a promising treatment option for patients who develop obstructions of their colonic anastomosis sites due to cancer recurrence. PMID: 25320530 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Kim JH, Lee JJ, Cho JH, Kim KO, Chung JW, Kim YJ, Kwon KA, Park DK, Kim JH Tags: World J Gastroenterol Source Type: research

Stratified computed tomography findings improve diagnostic accuracy for appendicitis.
CONCLUSION: Appendiceal diameter and wall thickening, fat stranding, and absence of intraluminal air can be used to increased diagnostic accuracy for appendicitis with equivocal CT findings. PMID: 25320531 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Park G, Lee SC, Choi BJ, Kim SJ Tags: World J Gastroenterol Source Type: research

Enhanced recovery after surgery vs conventional care in emergency colorectal surgery.
CONCLUSION: The ERAS programme in the setting of emergency colorectal surgery was safe and feasible. It achieved significantly shorter hospitalisation and faster recovery of bowel function. PMID: 25320532 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Lohsiriwat V Tags: World J Gastroenterol Source Type: research

Characteristics and clinical outcome of nonsteroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity among Chinese patients.
CONCLUSION: The injury typically occurred after an overdose of NSAIDs. The risk factors include age older than 60 years, alcohol use, positive HBV markers, extracellular volume depletion and RAAS inhibitor combined use. PMID: 25320533 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Cao YL, Tian ZG, Wang F, Li WG, Cheng DY, Yang YF, Gao HM Tags: World J Gastroenterol Source Type: research

Laparoscopic spleen-preserving distal pancreatectomy for pancreatic neoplasms: A retrospective study.
CONCLUSION: LSPDP is a safe, feasible and effective procedure for the treatment of benign and low-grade malignant tumors of the distal pancreas. PMID: 25320534 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Yan JF, Xu XW, Jin WW, Huang CJ, Chen K, Zhang RC, Harsha A, Mou YP Tags: World J Gastroenterol Source Type: research

Simultaneous modulated accelerated radiation therapy for esophageal cancer: A feasibility study.
CONCLUSION: SMART offers the potential for a 6 Gy simultaneous escalation in the irradiation dose delivered to the primary tumor of EC and improves the sparing of normal tissues. PMID: 25320535 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Zhang WZ, Chen JZ, Li DR, Chen ZJ, Guo H, Zhuang TT, Li DS, Zhou MZ, Chen CZ Tags: World J Gastroenterol Source Type: research

Endoscopic full-thickness resection for gastric submucosal tumors arising from the muscularis propria layer.
CONCLUSION: EFR is efficacious, safe and minimally invasive for patients with gastric SMTs arising from the muscularis propria layer. This technique is able to resect deep gastric lesions while providing precise pathological information about the lesion. With the development of EFR, the indications of endoscopic resection might be extended. PMID: 25320536 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Huang LY, Cui J, Lin SJ, Zhang B, Wu CR Tags: World J Gastroenterol Source Type: research

S-1 plus gemcitabine chemotherapy followed by concurrent radiotherapy and maintenance therapy with S-1 for unresectable pancreatic cancer.
CONCLUSION: The combination of S-1 with gemcitabine followed by oral S-1 with IMRT and maintenance therapy with S-1 alone in patients with locally advanced pancreatic cancer may be considered a well-tolerated, promising treatment regimen. PMID: 25320537 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Ke QH, Zhou SQ, Yang JY, Du W, Liang G, Lei Y, Luo F Tags: World J Gastroenterol Source Type: research

Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage.
CONCLUSION: Severe epistaxis in patients with ESLD is (1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH; and (2) associated with a high mortality rate in patients not receiving OLT. PMID: 25320538 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Camus M, Jensen DM, Matthews JD, Ohning GV, Kovacs TO, Jutabha R, Ghassemi KA, Machicado GA, Dulai GS Tags: World J Gastroenterol Source Type: research

Small intestinal bacterial overgrowth in inactive Crohn's disease: Influence of thiopurine and biological treatment.
CONCLUSION: Immunosuppressants and/or biological drugs do not induce SIBO in inactive CD. Fistulizing disease pattern and meteorism are associated with SIBO. PMID: 25320539 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Sánchez-Montes C, Ortiz V, Bastida G, Rodríguez E, Yago M, Beltrán B, Aguas M, Iborra M, Garrigues V, Ponce J, Nos P Tags: World J Gastroenterol Source Type: research

Magnetic resonance enterography in refractory iron deficiency anemia: A pictorial overview.
CONCLUSION: MRE is a non-invasive and effective alternative for evaluating possible malignancies of the small intestines and can serve as a guide for a second-look endoscopy. PMID: 25320540 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Cengic I, Tureli D, Aydin H, Bugdayci O, Imeryuz N, Tuney D Tags: World J Gastroenterol Source Type: research

Apolipoprotein C3 (-455T>C) polymorphism confers susceptibility to nonalcoholic fatty liver disease in the Southern Han Chinese population.
CONCLUSION: APOC3 (-455T>C) genetic variation is involved in the susceptibility to developing NAFLD, IR, hypertension, hypertriglyceridemia, and low HDL in the Southern Chinese Han population. PMID: 25320541 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Li MR, Zhang SH, Chao K, Liao XH, Yao JY, Chen MH, Zhong BH Tags: World J Gastroenterol Source Type: research

Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases.
CONCLUSION: The available evidence presented in this review indicates that enhanced survival times can be achieved for CPM after combined treatment with CRS and IPC. PMID: 25320542 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Mirnezami R, Moran BJ, Harvey K, Cecil T, Chandrakumaran K, Carr N, Mohamed F, Mirnezami AH Tags: World J Gastroenterol Source Type: research

Biliary stenting with or without sphincterotomy for malignant biliary obstruction: A meta-analysis.
CONCLUSION: EST before stent placement may be useful in reducing the incidence of PEP. However, EST-related complications, such as bleeding and perforation, may offset this effect. PMID: 25320543 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Cui PJ, Yao J, Zhao YJ, Han HZ, Yang J Tags: World J Gastroenterol Source Type: research

Accuracy of early detection of colorectal tumours by stool methylation markers: A meta-analysis.
CONCLUSION: Stool-based DNA testing may be useful for noninvasively diagnosing colorectal tumours and SFRP2 methylation is a promising marker that has great potential in early CRC diagnosis. PMID: 25320544 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Zhang H, Qi J, Wu YQ, Zhang P, Jiang J, Wang QX, Zhu YQ Tags: World J Gastroenterol Source Type: research

Bone marrow-derived mesenchymal stem cell therapy for decompensated liver cirrhosis: A meta-analysis.
CONCLUSION: BM-MSC infusion in the treatment of decompensated liver cirrhosis improved liver function. At the end of year 1, there were no serious side effects or complications. PMID: 25320545 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Pan XN, Zheng LQ, Lai XH Tags: World J Gastroenterol Source Type: research

Intestinal ascariasis at pediatric emergency room in a developed country.
Abstract Ascaris lumbricoides infection is rare among children in developed countries. Although large numbers of adult Ascaris in the small intestine can cause various abdominal symptoms, this infection remains asymptomatic until the number of worms in the intestine considerably increases in most cases. Ascaris causing bilious vomiting suggesting ileus is rare, especially in developed countries. A 6-year-old boy who lived in Japan, presented with abdominal colic, bilious vomiting at the pediatric emergency room. He appeared pale, and had no abdominal distention, tenderness, palpable abdominal mass, or findings of d...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Umetsu S, Sogo T, Iwasawa K, Kondo T, Tsunoda T, Oikawa-Kawamoto M, Komatsu H, Inui A, Fujisawa T Tags: World J Gastroenterol Source Type: research

Intramedullary spinal cord metastasis from pancreatic neuroendocrine tumor.
Abstract Intramedullary spinal cord metastasis (ISCM) is very rare and its optimal treatment remains controversial. Pancreatic neuroendocrine tumor (pNET) is a rare tumor that usually presents with hepatic metastasis. Hepatic failure due to tumor progression is the major cause of death in cases of pNET. To date, no report has described a case of ISCM from pNET. Although spinal cord metastasis of a solid tumor is uncommon, it is a critical condition that can cause a potentially irreversible loss of neurologic function. Here, we report the case of a 45-year-old man who presented with leg weakness and voiding difficul...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Kim JH, Hyun CL, Han SH Tags: World J Gastroenterol Source Type: research

Complete body-neck torsion of the gallbladder: A case report.
We present a case of acute body-neck gallbladder torsion in an elderly man, and we review the radiologic findings of magnetic resonance imaging, computed tomography, and ultrasonography. The radiologic findings in the present case were helpful in obtaining a preoperative diagnosis of gallbladder torsion. The diagnosis was confirmed by T2-weighted magnetic resonance images, which showed an intra-gallbladder segment located between the body and neck of the gallbladder, with a notable crease within this segment. PMID: 25320548 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Pu TW, Fu CY, Lu HE, Cheng WT Tags: World J Gastroenterol Source Type: research

Successful treatment of refractory gastric antral vascular ectasia by distal gastrectomy: A case report.
Abstract Gastric antral vascular ectasia (GAVE) is an uncommon and often neglected cause of gastric hemorrhage. The treatments for GAVE include surgery, endoscopy and medical therapies. Here, we report an unusual case of GAVE. A 72-year-old man with a three-month history of recurrent melena was diagnosed with GAVE. Endoscopy revealed the classical "watermelon stomach" appearance of GAVE and complete pyloric involvement. Melena reoccurred three days after argon plasma coagulation treatment, and the level of hemoglobin dropped to 47 g/L. The patient was then successfully treated with distal gastrectomy with Billroth ...
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Jin T, Fei BY, Zheng WH, Wang YX Tags: World J Gastroenterol Source Type: research

Small intestinal vascular malformation bleeding: A case report with imaging findings.
This report systemically emphasizes the imaging findings of small intestinal vascular malformation bleeding. PMID: 25320550 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Cui J, Huang LY, Lin SJ, Yi LZ, Wu CR, Zhang B Tags: World J Gastroenterol Source Type: research

Treatment of peri-anal fistula in Crohn's disease.
Abstract Anal fistulas are a common manifestation of Crohn's disease (CD). The first manifestation of the disease is often in the peri-anal region, which can occur years before a diagnosis, particularly in CD affecting the colon and rectum. The treatment of peri-anal fistulas is difficult and always multidisciplinary. The European guidelines recommend combined surgical and medical treatment with biologic drugs to achieve best results. Several different surgical techniques are currently employed. However, at the moment, none of these techniques appear superior to the others in terms of healing rate. Surgery is alway...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Sica GS, Di Carlo S, Tema G, Montagnese F, Del Vecchio Blanco G, Fiaschetti V, Maggi G, Biancone L Tags: World J Gastroenterol Source Type: research