World Journal of Gastroenterology : WJG World Journal of Gastroenterology : WJG RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the latest items in this publication.

Current treatment of chronic hepatitis C in China: Dilemma and potential problems.
Abstract Major advances have been made in the treatment of chronic hepatitis C virus (HCV) infection with the advent of direct-acting antiviral agents (DAAs). China has the most cases of HCV infection worldwide, but none of the DAAs has been approved in mainland China so far, and interferon (IFN)-α-based treatment remains the standard of care. HCV patients without response or with contraindications to IFN-based therapy have no alternative options. However, many patients buy DAAs, especially the generic forms of sofosbuvir, from other countries or areas. Under these circumstances, the use of these drugs may cause m...
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Han QY, Liu ZW Tags: World J Gastroenterol Source Type: research

HER2 testing in gastric cancer: An update.
Abstract Human epidermal growth factor receptor 2 (HER2) overexpression is increasingly recognized as a frequent molecular abnormality in gastric and gastroesophageal cancer. With the recent introduction of HER2 molecular targeted therapy for patients with advanced gastric cancer, determination of HER2 status is crucial in order to select patients who may benefit from this treatment. This paper provides an update on our knowledge of HER2 in gastric and gastroesophageal cancer, including the prognostic relevance of HER2, the key differences between HER2 protein expression interpretation in breast and gastric cancer,...
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Abrahao-Machado LF, Scapulatempo-Neto C Tags: World J Gastroenterol Source Type: research

Minimally invasive surgery for upper gastrointestinal cancer: Our experience and review of the literature.
Abstract Minimally invasive surgery (MIS) for upper gastrointestinal (GI) cancer, characterized by minimal access, has been increasingly performed worldwide. It not only results in better cosmetic outcomes, but also reduces intraoperative blood loss and postoperative pain, leading to faster recovery; however, endoscopically enhanced anatomy and improved hemostasis via positive intracorporeal pressure generated by CO2 insufflation have not contributed to reduction in early postoperative complications or improvement in long-term outcomes. Since 1995, we have been actively using MIS for operable patients with resectab...
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Suda K, Nakauchi M, Inaba K, Ishida Y, Uyama I Tags: World J Gastroenterol Source Type: research

Recent updates of precision therapy for gastric cancer: Towards optimal tailored management.
Abstract Signaling pathways of gastric carcinogenesis and gastric cancer progression are being avidly studied to seek optimal treatment of gastric cancer. Among them, hepatocyte growth factor (HGF)/c-MET, phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathways have been widely investigated. Their aberrant expression or mutation has been significantly associated with advanced stage or poor prognosis of gastric cancer. Recently, aberrations of immune checkpoints including programmed cell death-1/programmed ce...
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Joo MK, Park JJ, Chun HJ Tags: World J Gastroenterol Source Type: research

Auto immune hepatitis.
Abstract To provide an update of the latest trends in epidemiology, clinical course, diagnostics, complications and treatment of auto immune hepatitis (AIH). A search of the MEDLINE database was performed using the search terms: "auto immune hepatitis", "clinical presentation", "symptoms", "signs", "diagnosis", "auto antibodies", "laboratory values", "serology", "histopathology", "histology", "genetics", "HLA genes", "non-HLA genes", "environment", "epidemiology", "prevalence", "incidence", "demographics", "complications", "HCC", "PBC", "PSC", "corticosteroid", "therapy", "treatment", "alternative treatment". Engli...
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: van Gerven NM, de Boer YS, Mulder CJ, van Nieuwkerk CM, Bouma G Tags: World J Gastroenterol Source Type: research

Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis.
CONCLUSION: Altered TPH2 expression in colonic serotonergic nerves of patients with HSCR complicated by HAEC may contribute to intestinal secretory and motor disturbances, including recurrent HAEC. PMID: 27217698 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Coyle D, Murphy JM, Doyle B, O'Donnell AM, Gillick J, Puri P Tags: World J Gastroenterol Source Type: research

Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction.
CONCLUSION: Warm IRI impairs steatotic liver Complex-I activity and function. The protective effects of IPC in steatotic livers may not be mediated through mitochondria. PMID: 27217699 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Chu MJ, Premkumar R, Hickey AJ, Jiang Y, Delahunt B, Phillips AR, Bartlett AS Tags: World J Gastroenterol Source Type: research

Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy.
CONCLUSION: In this study, we demonstrated a potential role for cardiac mTOR in the pathophysiology of cirrhotic cardiomyopathy. Rapamycin normalized the inotropic effect and altered phosphorylated-mTOR expression and myocardial localization in cirrhotic rats. PMID: 27217700 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Saeedi Saravi SS, Ghazi-Khansari M, Ejtemaei Mehr S, Nobakht M, Mousavi SE, Dehpour AR Tags: World J Gastroenterol Source Type: research

Qinggan Huoxue Recipe suppresses epithelial-to-mesenchymal transition in alcoholic liver fibrosis through TGF-β1/Smad signaling pathway.
CONCLUSION: Qinggan Huoxue Recipe inhibits EMT in ALF rats by modulating the TGF-β1/Smad signaling pathway, suggesting that the mechanism underlying the amelioration of ALF induced by QGHXR is associated with this pathway. PMID: 27217701 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Wu T, Chen JM, Xiao TG, Shu XB, Xu HC, Yang LL, Xing LJ, Zheng PY, Ji G Tags: World J Gastroenterol Source Type: research

Laparoscopic colonic anastomosis using a degradable stent in a porcine model.
CONCLUSION: Laparoscopic colonic anastomosis with a degradable stent is a simple, rapid, and safe procedure in this porcine model. PMID: 27217702 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Ma L, Cai XJ, Wang HH, Yu YL, Huang DY, Ge GJ, Hu HY, Yu SC Tags: World J Gastroenterol Source Type: research

Plasma long noncoding RNA expression profile identified by microarray in patients with Crohn's disease.
CONCLUSION: The plasma lncRNAs profiles provide preliminary data for the non-invasive diagnosis of CD and a resource for further specific lncRNA-mRNA pathway exploration. PMID: 27217703 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Chen D, Liu J, Zhao HY, Chen YP, Xiang Z, Jin X Tags: World J Gastroenterol Source Type: research

Veterans health administration hepatitis B testing and treatment with anti-CD20 antibody administration.
CONCLUSION: While HBV testing of Veterans has increased prior to anti-CD20 Ab, few HBV+ patients received HBV antivirals, suggesting electronic health record algorithms may enhance health outcomes. PMID: 27217704 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Hunt CM, Beste LA, Lowy E, Suzuki A, Moylan CA, Tillmann HL, Ioannou GN, Lim JK, Kelley MJ, Provenzale D Tags: World J Gastroenterol Source Type: research

Contrast-enhanced ultrasound of histologically proven hepatic epithelioid hemangioendothelioma.
CONCLUSION: CEUS allows for characterization of unequivocal FLL. By analyzing the hypoenhancement in the PVLP, CEUS can determine the malignant nature of HEHE. PMID: 27217705 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Dong Y, Wang WP, Cantisani V, D'Onofrio M, Ignee A, Mulazzani L, Saftoiu A, Sparchez Z, Sporea I, Dietrich CF Tags: World J Gastroenterol Source Type: research

Lymph node dissection in esophageal carcinoma: Minimally invasive esophagectomy vs open surgery.
CONCLUSION: For stages T1 and T2 esophageal squamous cell carcinoma, the lymph node dissection result after MIE was comparable to that achieved by open surgery. However, the efficacy of MIE in lymphadenectomy for stage T3 esophageal squamous cell carcinoma, particularly at left para-RLN site, remains to be improved. PMID: 27217706 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Ye B, Zhong CX, Yang Y, Fang WT, Mao T, Ji CY, Li ZG Tags: World J Gastroenterol Source Type: research

Chinese physicians' perceptions of fecal microbiota transplantation.
CONCLUSION: Chinese physicians have awareness and a high acceptance of FMT, especially gastroenterologists, which provides the grounds and conditions for the development of this novel treatment in China. Physicians' greatest concerns were patient acceptability and absence of guidelines. PMID: 27217707 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Ren RR, Sun G, Yang YS, Peng LH, Wang SF, Shi XH, Zhao JQ, Ban YL, Pan F, Wang XH, Lu W, Ren JL, Song Y, Wang JB, Lu QM, Bai WY, Wu XP, Wang ZK, Zhang XM, Chen Y Tags: World J Gastroenterol Source Type: research

Hybrid, sequential and concomitant therapies for Helicobacter pylori eradication: A systematic review and meta-analysis.
CONCLUSION: Compared with ST or CT, HT yields a similar eradication rate, high compliance rate, and acceptable safety profiles. PMID: 27217708 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Song ZQ, Zhou LY Tags: World J Gastroenterol Source Type: research

Endoscopic resection of sparganosis presenting as colon submucosal tumor: A case report.
In this report, we aimed to highlight the clinical presentation of Sparganum infection as a rectal submucosal tumor. PMID: 27217709 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Kim JK, Baek DH, Lee BE, Kim GH, Song GA, Park do Y Tags: World J Gastroenterol Source Type: research

Successful management of adult lymphoma-associated intussusception by laparoscopic reduction and appendectomy.
We report a 31-year-old man diagnosed with human immunodeficiency virus who was being treated with antiretroviral therapy. He presented with nausea, vomiting, poor appetite, and intermittent, cramping abdominal pain for over 1 wk. Abdominal computed tomography revealed a well-defined homogeneous mass in the mesenteric root region, together with a long segmental wall thickening in the ileum with ileocolic-type intussusception, which was suspected to be caused by a lymphoma. The intussusception was successfully laparoscopically reduced, and the tumor involvement of the appendix was confirmed by appendectomy with intraoperati...
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Yang TW, Lin YY, Tsuei YW, Chen YL, Huang CY, Hsu SD Tags: World J Gastroenterol Source Type: research

von Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis.
Abstract Increased thrombotic potential within the liver sinusoids due to local endothelial production of von Willebrand factor antigen macromolecules could represent an additional therapeutic target of portal hypertension in patients with cirrhosis. In this case, anti-inflammatory and antithrombotic drugs could modulate portal pressure by preventing the formation of intrahepatic platelet-induced microthrombi. PMID: 27217711 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2016 Category: Gastroenterology Authors: Kalambokis GN, Baltayiannis G, Christodoulou D Tags: World J Gastroenterol Source Type: research

Thrombin activation and liver inflammation in advanced hepatitis C virus infection.
Abstract Hepatitis C virus (HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein r...
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: González-Reimers E, Quintero-Platt G, Martín-González C, Pérez-Hernández O, Romero-Acevedo L, Santolaria-Fernández F Tags: World J Gastroenterol Source Type: research

Liver transplantation: Current status and challenges.
Abstract Great progress has been made in the field of liver transplantation over the past two decades. This progress, however, also brings up the next set of challenges: First, organ shortage remains a major limitation, and accounts for a large proportion of wait list mortality. While living donation has successfully increased the total number of liver transplants done in Asian countries, the total number of such transplants has been stagnant in the western hemisphere. As such, there has been a significant effort over the past decade to increase the existing deceased donor pool. This effort has resulted in a greate...
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Jadlowiec CC, Taner T Tags: World J Gastroenterol Source Type: research

Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer.
Abstract The incidence of pancreatic ductal adenocarcinoma (PDA) is on the rise, and the prognosis is extremely poor because PDA is highly aggressive and notoriously difficult to treat. Although gemcitabine- or 5-fluorouracil-based chemotherapy is typically offered as a standard of care, most patients do not survive longer than 1 year. Therefore, the development of alternative therapeutic approaches for patients with PDA is imperative. As PDA cells express numerous tumor-associated antigens that are suitable vaccine targets, one promising treatment approach is cancer vaccines. During the last few decades, cell-base...
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Kajihara M, Takakura K, Kanai T, Ito Z, Matsumoto Y, Shimodaira S, Okamoto M, Ohkusa T, Koido S Tags: World J Gastroenterol Source Type: research

Combined hepatocellular cholangiocarcinoma: Controversies to be addressed.
Abstract Combined hepatocellular cholangiocarcinoma (CHC) accounts for 0.4%-14.2% of primary liver cancer cases and possesses pathological features of both hepatocellular carcinoma and cholangiocarcinoma. Since this disease was first described and classified in 1949, the classification of CHC has continuously evolved. The latest definition and classification of CHC by the World Health Organization is based on the speculation that CHC arises from hepatic progenitor cells. However, there is no evidence demonstrating the common origin of different components of CHC. Furthermore, the definition of CHC subtypes is still...
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Wang AQ, Zheng YC, Du J, Zhu CP, Huang HC, Wang SS, Wu LC, Wan XS, Zhang HH, Miao RY, Sang XT, Zhao HT Tags: World J Gastroenterol Source Type: research

Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma: Characterization in a 3D-cell culture model.
CONCLUSION: We show that a 3D-cell culture model could provide deeper insight into understanding the biology of PDAC and allow for the detection of marked differences in the phenotype of PDAC cells grown in 3D-spheroids. PMID: 27182158 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Gagliano N, Celesti G, Tacchini L, Pluchino S, Sforza C, Rasile M, Valerio V, Laghi L, Conte V, Procacci P Tags: World J Gastroenterol Source Type: research

Role of estrogen receptor β selective agonist in ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis.
CONCLUSION: For OVX rats with liver cirrhosis, DPN suppressed liver RhoA/ROCK signal, facilitated NO/PKG pathways, and decreased IHVR, giving rise to reduced portal pressure. Therefore, DPN represents a relevant treatment choice against PHT in cirrhotic patients, especially postmenopausal women. PMID: 27182159 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Zhang CG, Zhang B, Deng WS, Duan M, Chen W, Wu ZY Tags: World J Gastroenterol Source Type: research

miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate.
CONCLUSION: miR-30b inhibited autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate. PMID: 27182160 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Li SP, He JD, Wang Z, Yu Y, Fu SY, Zhang HM, Zhang JJ, Shen ZY Tags: World J Gastroenterol Source Type: research

Dissecting characteristics and dynamics of differentially expressed proteins during multistage carcinogenesis of human colorectal cancer.
CONCLUSION: These findings give insights into our understanding of the mechanisms of colorectal carcinogenesis and provide clues for further investigation of carcinogenesis and identification of biomarkers. PMID: 27182161 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Peng F, Huang Y, Li MY, Li GQ, Huang HC, Guan R, Chen ZC, Liang SP, Chen YH Tags: World J Gastroenterol Source Type: research

Elevated serum interleukin-38 level at baseline predicts virological response in telbivudine-treated patients with chronic hepatitis B.
CONCLUSION: Elevated serum IL-38 levels in untreated CHB patients reflect ongoing liver injury. Higher serum IL-38 levels before treatment indicate a greater probability of VR to LdT treatment. PMID: 27182162 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Wang HJ, Jiang YF, Wang XR, Zhang ML, Gao PJ Tags: World J Gastroenterol Source Type: research

Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma.
CONCLUSION: Higher expression of HBx and B7-H4 was correlated with tumor progression of HBV-HCC, suggesting that B7-H4 may be involved in facilitating HBV-related hepatocarcinogenesis. PMID: 27182163 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Hong B, Qian Y, Zhang H, Sang YW, Cheng LF, Wang Q, Gao S, Zheng M, Yao HP Tags: World J Gastroenterol Source Type: research

Predictive factors for survival and score application in liver retransplantation for hepatitis C recurrence.
CONCLUSION: Antiviral therapy before and after retransplantation had a substantial impact on survival in the context of retransplantation for HCV recurrence, and with the new direct-acting antivirals now available, outcomes should be even better in the future. PMID: 27182164 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Song AT, Sobesky R, Vinaixa C, Dumortier J, Radenne S, Durand F, Calmus Y, Rousseau G, Latournerie M, Feray C, Delvart V, Roche B, Haim-Boukobza S, Roque-Afonso AM, Castaing D, Abdala E, D'Albuquerque LA, Duclos-Vallée JC, Berenguer M, Samuel D Tags: World J Gastroenterol Source Type: research

Video capsule endoscopy in left ventricular assist device recipients with obscure gastrointestinal bleeding.
CONCLUSION: VCE can be safely performed in LVAD recipients with a diagnostic yield of 40%. VCE does not affect recurrent bleeding in LVAD patients regardless of findings. PMID: 27182165 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Amornsawadwattana S, Nassif M, Raymer D, LaRue S, Chen CH Tags: World J Gastroenterol Source Type: research

Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia.
CONCLUSION: DNA methylation occurs in cases of gastric-type (non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cagA positive infection. PMID: 27182166 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Herrera-Goepfert R, Oñate-Ocaña LF, Mosqueda-Vargas JL, Herrera LA, Castro C, Mendoza J, González-Barrios R Tags: World J Gastroenterol Source Type: research

Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia.
CONCLUSION: H. pylori infection as well as H. pylori-associated gastric diseases are risk factors for colorectal neoplasia. PMID: 27182167 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Qing Y, Wang M, Lin YM, Wu D, Zhu JY, Gao L, Liu YY, Yin TF Tags: World J Gastroenterol Source Type: research

Changes in patients' symptoms and gastric emptying after Helicobacter pylori treatment.
CONCLUSION: FD patients have delayed gastric emptying. H. pylori infection treatment helps to improve symptoms of dyspepsia and is a reasonable choice for treatment in clinical practice. PMID: 27182168 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Zhang CL, Geng CH, Yang ZW, Li YL, Tong LQ, Gao P, Gao YQ Tags: World J Gastroenterol Source Type: research

Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials.
CONCLUSION: Our results suggest a modest chemopreventive effect of calcium supplements against recurrent colorectal adenomas over a period of 36 to 60 mo. Further research is warranted. PMID: 27182169 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Bonovas S, Fiorino G, Lytras T, Malesci A, Danese S Tags: World J Gastroenterol Source Type: research

Pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from transverse colon cancer.
We report here a case of pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from colon cancer. A 65-year-old female with a history of surgery for transverse colon cancer and peritoneal dissemination suffered from metachronous ovarian metastases during treatment with systemic chemotherapy. At first, neither ascites nor pleural effusion was observed, but she later complained of progressive abdominal distention and dyspnea caused by rapidly increasing ascites and pleural effusion and rapidly enlarging ovarian metastases. Abdominocenteses were repeated, and cytological examinations of the fluids were all negat...
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Kyo K, Maema A, Shirakawa M, Nakamura T, Koda K, Yokoyama H Tags: World J Gastroenterol Source Type: research

Isolated splenic metastasis from colon cancer: Case report.
Abstract Isolated splenic metastases from colorectal cancer are very rare clinical entities and when they are present, they usually manifest widely disseminated disease. In this paper we report a case of metachronous solitary isolated splenic metastasis from colon cancer in a 64-year-old woman who was successfully treated by laparoscopic splenectomy. We discuss the pathological and clinical aspects of this condition. We furthermore comment on the diagnostic and therapeutic options of this rare entity through our observation of the case and consideration of the 31 case reports published in the literature. PMID:...
Source: World Journal of Gastroenterology : WJG - May 14, 2016 Category: Gastroenterology Authors: Abdou J, Omor Y, Boutayeb S, Elkhannoussi B, Errihani H Tags: World J Gastroenterol Source Type: research

Dendritic cell-based cancer immunotherapy for colorectal cancer.
Abstract Colorectal cancer (CRC) is one of the most common cancers and a leading cause of cancer-related mortality worldwide. Although systemic therapy is the standard care for patients with recurrent or metastatic CRC, the prognosis is extremely poor. The optimal sequence of therapy remains unknown. Therefore, alternative strategies, such as immunotherapy, are needed for patients with advanced CRC. This review summarizes evidence from dendritic cell-based cancer immunotherapy strategies that are currently in clinical trials. In addition, we discuss the possibility of antitumor immune responses through immunoinhibi...
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Kajihara M, Takakura K, Kanai T, Ito Z, Saito K, Takami S, Shimodaira S, Okamoto M, Ohkusa T, Koido S Tags: World J Gastroenterol Source Type: research

Precore/core region mutations of hepatitis B virus related to clinical severity.
Abstract Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem, with more than 350 million chronically infected people worldwide and over 1 million annual deaths due to cirrhosis and liver cancer. HBV mutations are primarily generated due both to a lack of proofreading capacity by HBV polymerase and to host immune pressure, which is a very important factor for predicting disease progression and therapeutic outcomes. Several types of HBV precore/core (preC/C) mutations have been described to date. The host immune response against T cells drives mutation in...
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Kim H, Lee SA, Do SY, Kim BJ Tags: World J Gastroenterol Source Type: research

Post-ablation surveillance in Barrett's esophagus: A review of the literature.
Abstract Barrett's esophagus (BE) is a pre-malignant condition affecting up to 15% of patients with gastroesophageal reflux disease. Neoplastic Barrett's mucosa is defined as harboring high grade dysplasia or intra-mucosal cancer, and carries a high risk of progression to esophageal adenocarcinoma. The rising incidence of Barrett's lesions along with the high morbidity of surgical approaches has led to the development of numerous validated endoscopic techniques capable of eradicating neoplastic mucosa in a minimally invasive manner. While there has been widespread adoption of these techniques, less is known about o...
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Stier MW, Konda VJ, Hart J, Waxman I Tags: World J Gastroenterol Source Type: research

Recent developments and innovations in gastric cancer.
Abstract Gastric cancer has an important place in the worldwide incidence of cancer and cancer-related deaths. It can metastasize to the lymph nodes in the early stages, and lymph node metastasis is an important prognostic factor. Surgery is a very important part of gastric cancer treatment. A D2 lymphadenectomy is the standard surgical treatment for cT1N+ and T2-T4 cancers, which are potentially curable. Recently, the TNM classification system was reorganized, and the margins for gastrectomy and lymphadenectomy were revised. Endoscopic, laparoscopic and robotic treatments of gastric cancer have progressed rapidly ...
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Mihmanli M, Ilhan E, Idiz UO, Alemdar A, Demir U Tags: World J Gastroenterol Source Type: research

Growth hormone abolishes the negative effects of everolimus on intestinal wound healing.
CONCLUSION: Inhibition of intestinal wound healing by everolimus is partially neutralized by simultaeous treatment with hGH. Both inflammation as well as collagen deposition is influenced by hGH. PMID: 27158200 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Küper MA, Trütschel S, Weinreich J, Königsrainer A, Beckert S Tags: World J Gastroenterol Source Type: research

Effect of the manipulation of the duodenal papilla during double balloon enteroscopy.
CONCLUSION: The manipulation of the duodenal papilla by the inflated overtube's balloon during DBE causes pancreatic structural damage and increased biochemical markers associated with pancreatitis. PMID: 27158201 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Latorre R, López-Albors O, Soria F, Candanosa E, Pérez-Cuadrado E Tags: World J Gastroenterol Source Type: research

Shear wave elastography results correlate with liver fibrosis histology and liver function reserve.
CONCLUSION: SWE LSM shows a good correlation with histologic fibrosis grading and pharmacologic quantitative liver function reserve in experimental severe fibrosis and cirrhosis. PMID: 27158202 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Feng YH, Hu XD, Zhai L, Liu JB, Qiu LY, Zu Y, Liang S, Gui Y, Qian LX Tags: World J Gastroenterol Source Type: research

Activation of AMPK/MnSOD signaling mediates anti-apoptotic effect of hepatitis B virus in hepatoma cells.
CONCLUSION: Our results suggest that HBV suppresses mitochondrial superoxide level and exerts an anti-apoptotic effect by activating AMPK/MnSOD signaling pathway, which may provide a novel pharmacological strategy to prevent HCC. PMID: 27158203 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Li L, Hong HH, Chen SP, Ma CQ, Liu HY, Yao YC Tags: World J Gastroenterol Source Type: research

Inhibitory effect of miR-125b on hepatitis C virus core protein-induced TLR2/MyD88 signaling in THP-1 cells.
CONCLUSION: The inverse correlation between miR-125b and cytokine expression after HCV core challenge suggests that miR-125b may negatively regulate HCV-induced immune responses by targeting TLR2/MyD88 signaling in monocytes. PMID: 27158204 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Peng C, Wang H, Zhang WJ, Jie SH, Tong QX, Lu MJ, Yang DL Tags: World J Gastroenterol Source Type: research

Non-alcoholic fatty liver disease is not associated with a lower health perception.
CONCLUSION: Fatty liver without clinically significant liver disease does not have independent impact on self-health perception. PMID: 27158205 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Mlynarsky L, Schlesinger D, Lotan R, Webb M, Halpern Z, Santo E, Shibolet O, Zelber-Sagi S Tags: World J Gastroenterol Source Type: research

Significance of functional hepatic resection rate calculated using 3D CT/(99m)Tc-galactosyl human serum albumin single-photon emission computed tomography fusion imaging.
CONCLUSION: Our results suggest that FHRR is an important deciding factor for major hepatectomy, because FHRR and PHRR may be discrepant owing to insufficient hepatic inflow and congestion in patients with preoperative therapies, macroscopic vascular invasion, and/or a tumor volume of > 1000 mL. PMID: 27158206 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Tsuruga Y, Kamiyama T, Kamachi H, Shimada S, Wakayama K, Orimo T, Kakisaka T, Yokoo H, Taketomi A Tags: World J Gastroenterol Source Type: research

Clinicopathological features of familial adenomatous polyposis in Korean patients.
CONCLUSION: Identification of APC mutations should aid in the diagnosis and counseling of family members in terms of early diagnosis and management of FAP. PMID: 27158207 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Jung SM, Yoon YS, Lim SB, Yu CS, Kim JC Tags: World J Gastroenterol Source Type: research

Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis.
CONCLUSION: Adacolumn(®) GMA apheresis treatment was effective in pediatric patients with moderate active Ulcerative Colitis. No new safety signals were reported. The present data contribute to considering GMA apheresis as a therapeutic option in pediatric patients having failed first line therapy. PMID: 27158208 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2016 Category: Gastroenterology Authors: Ruuska T, Küster P, Grahnquist L, Lindgren F, Wewer AV Tags: World J Gastroenterol Source Type: research