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World Journal of Gastroenterology : WJG

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Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis.
Abstract Non-alcoholic fatty liver disease (NAFLD) is a widely prevalent hepatic disorder that covers wide spectrum of liver pathology. NAFLD is strongly associated with liver inflammation, metabolic hyperlipidaemia and insulin resistance. Frequently, NAFLD has been considered as the hepatic manifestation of metabolic syndrome. The pathophysiology of NAFLD has not been fully elucidated. Some patients can remain in the stage of simple steatosis, which generally is a benign condition; whereas others can develop liver inflammation and progress into non-alcoholic steatohepatitis, fibrosis, cirrhosis and hepatocellular ...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Lim JW, Dillon J, Miller M Tags: World J Gastroenterol Source Type: research

Modern approach to the clinical management of non-alcoholic fatty liver disease.
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common and emerging form of chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis, which may progress to cirrhosis, liver cancer, and liver mortality. Common metabolic diseases, which are well established cardiovascular risk factors, have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population. The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible ca...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Del Ben M, Polimeni L, Baratta F, Pastori D, Loffredo L, Angelico F Tags: World J Gastroenterol Source Type: research

Nonalcoholic fatty liver disease and polycystic ovary syndrome.
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the Western world comprising a spectrum of liver damage from fatty liver infiltration to end-stage liver disease, in patients without significant alcohol consumption. Increased prevalence of NAFLD has been reported in patients with polycystic ovary syndrome (PCOS), one of the most common endocrinopathies in premenopausal women, which has been redefined as a reproductive and metabolic disorder after the recognition of the important role of insulin resistance in the pathophysiology of the syndrome. Obesity, in parti...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Vassilatou E Tags: World J Gastroenterol Source Type: research

Experimental models of non-alcoholic fatty liver disease in rats.
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, and it persists at a high prevalence. NAFLD is characterised by the accumulation of triglycerides in the liver and includes a spectrum of histopathological findings, ranging from simple fatty liver through non-alcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis, which may progress to hepatocellular carcinoma. The pathogenesis of NAFLD is closely related to the metabolic syndrome and insulin resistance. Understanding the pathophysiology and treatment of NAFLD in humans has currently bee...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Kucera O, Cervinkova Z Tags: World J Gastroenterol Source Type: research

Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment.
Abstract Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2 diabetes are at a particularly high risk for developing the progressive forms of NAFLD, non-alcoholic steatohepatitis and associated advanced liver fibrosis. Moreover, diabetes is an independent risk factor for NAFLD progression, and for hepatocellular carcinoma development and liver-related mortality in prospective studies. Notwithstanding, patients with NAFLD have an elevated prevalence of prediabetes. Recent studies have shown that NAFLD presence pre...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Leite NC, Villela-Nogueira CA, Cardoso CR, Salles GF Tags: World J Gastroenterol Source Type: research

Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease.
Abstract Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are serious health problems worldwide. These two diseases have similar pathological spectra, ranging from simple hepatic steatosis to steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. Although most subjects with excessive alcohol or food intake experience simple hepatic steatosis, a small percentage of individuals will develop progressive liver disease. Notably, both ALD and NAFLD are frequently accompanied by extrahepatic complications, including cardiovascular disease and malignancy. The survival of patients with ALD...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Toshikuni N, Tsutsumi M, Arisawa T Tags: World J Gastroenterol Source Type: research

Nonalcoholic fatty liver disease and cardiovascular disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are two diseases that are common in the general population. To date, many studies have been conducted and demonstrate a direct link between NAFLD and CVD, but the exact mechanisms for this complex relationship are not well established. A systematic search of the PubMed database revealed that several common mechanisms are involved in many of the local and systemic manifestations of NAFLD and lead to an increased cardiovascular risk. The possible mechanisms linking NAFLD and CVD include inflammation, oxidative stress, insulin resistanc...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Liu H, Lu HY Tags: World J Gastroenterol Source Type: research

Role of small bowel capsule endoscopy in the diagnosis and management of iron deficiency anemia in elderly: A comprehensive review of the current literature.
Abstract Iron deficiency anemia (IDA) is common and often under recognized problem in the elderly. It may be the result of multiple factors including a bleeding lesion in the gastrointestinal tract. Twenty percent of elderly patients with IDA have a negative upper and lower endoscopy and two-thirds of these have a lesion in the small bowel (SB). Capsule endoscopy (CE) provides direct visualization of entire SB mucosa, which was not possible before. It is superior to push enteroscopy, enteroclysis and barium radiography for diagnosing clinically significant SB pathology resulting in IDA. Angioectasia is one of the c...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Muhammad A, Vidyarthi G, Brady P Tags: World J Gastroenterol Source Type: research

Endoscopic ultrasound-guided treatments: Are we getting evidence based - a systematic review.
Abstract The continued need to develop less invasive alternatives to surgical and radiologic interventions has driven the development of endoscopic ultrasound (EUS)-guided treatments. These include EUS-guided drainage of pancreatic fluid collections, EUS-guided necrosectomy, EUS-guided cholangiography and biliary drainage, EUS-guided pancreatography and pancreatic duct drainage, EUS-guided gallbladder drainage, EUS-guided drainage of abdominal and pelvic fluid collections, EUS-guided celiac plexus block and celiac plexus neurolysis, EUS-guided pancreatic cyst ablation, EUS-guided vascular interventions, EUS-guided ...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Fabbri C, Luigiano C, Lisotti A, Cennamo V, Virgilio C, Caletti G, Fusaroli P Tags: World J Gastroenterol Source Type: research

Colonic polyps: Is it useful to characterize them with advanced endoscopy?
Abstract There have been major developments in endoscopic imaging techniques in recent years. Endoscopes with high definition and magnification can provide high quality images that allow for the histological estimation of lesions in vivo and in situ when combined with ancillary enhancement techniques such as chromoendoscopy (CE) and virtual CE (narrow band imaging fujinon intelligent chromoendoscopy, or i-Scan). Despite the enormous potential for these advanced techniques, their value and feasibility in the clinic are still doubted, particularly in cases of colonic polyps that are slated for removal, where in vivo ...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Lopez-Ceron M, Sanabria E, Pellise M Tags: World J Gastroenterol Source Type: research

c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer.
Abstract Pancreatic ductal adenocarcinoma is the 4(th) leading cause of cancer deaths in the United States. The majority of patients are candidates only for palliative chemotherapy, which has proven largely ineffective in halting tumor progression. One proposed mechanism of chemoresistance involves signaling via the mesenchymal-epithelial transition factor protein (MET), a previously established pathway critical to cell proliferation and migration. Here, we review the literature to characterize the role of MET in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of MET as ...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Delitto D, Vertes-George E, Hughes SJ, Behrns KE, Trevino JG Tags: World J Gastroenterol Source Type: research

Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation.
Abstract Pancreatic cancer carries a terrible prognosis, as the fourth most common cause of cancer death in the Western world. There is clearly a need for new therapies to treat this disease. One of the reasons no effective treatment has been developed in the past decade may in part, be explained by the diverse influences exerted by the tumour microenvironment. The tumour stroma cross-talk in pancreatic cancer can influence chemotherapy delivery and response rate. Thus, appropriate preclinical in vitro models which can bridge simple 2D in vitro cell based assays and complex in vivo models are required to understand...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Coleman SJ, Watt J, Arumugam P, Solaini L, Carapuca E, Ghallab M, Grose RP, Kocher HM Tags: World J Gastroenterol Source Type: research

hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: A systematic review.
Abstract High human equilibrative nucleoside transporter 1 (hENT1)-expression has shown a survival benefit in pancreatic cancer patients treated with gemcitabine in several studies. The aim of this systematic review was to summarize the results and try to assess the predictive value of hENT1 for determining gemcitabine outcome in pancreatic cancer. Relevant articles were obtained from PubMed, Embase and Cochrane databases. Studies evaluating hENT1-expression in pancreatic tumor cells from patients treated with gemcitabine were selected. Outcome measures were overall survival, disease-free survival (DFS), toxicity a...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Nordh S, Ansari D, Andersson R Tags: World J Gastroenterol Source Type: research

Liver zonation: Novel aspects of its regulation and its impact on homeostasis.
Abstract Liver zonation, the spatial separation of the immense spectrum of different metabolic pathways along the liver sinusoids, is fundamental for proper functioning of this organ. Recent progress in elucidating localization and interactions of different metabolic pathways by using "omics" techniques and novel approaches to couple them with refined spatial resolution and in characterizing novel master regulators of zonation by using transgenic mice has created the basis for a deeper understanding of core mechanisms of zonation and their impact on liver physiology, pathology and metabolic diseases. This review su...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Gebhardt R, Matz-Soja M Tags: World J Gastroenterol Source Type: research

Gastroenteric tube feeding: Techniques, problems and solutions.
Abstract Gastroenteric tube feeding plays a major role in the management of patients with poor voluntary intake, chronic neurological or mechanical dysphagia or gut dysfunction, and patients who are critically ill. However, despite the benefits and widespread use of enteral tube feeding, some patients experience complications. This review aims to discuss and compare current knowledge regarding the clinical application of enteral tube feeding, together with associated complications and special aspects. We conducted an extensive literature search on PubMed, Embase and Medline using index terms relating to enteral acc...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Blumenstein I, Shastri YM, Stein J Tags: World J Gastroenterol Source Type: research

High fat diet feeding results in gender specific steatohepatitis and inflammasome activation.
CONCLUSION: Our data indicate gender differences in NASH. Male mice fed a long-term HFD display steatohepatitis and inflammasome activation, whereas female mice have steatosis without inflammation. PMID: 25024607 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Ganz M, Csak T, Szabo G Tags: World J Gastroenterol Source Type: research

Novel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy.
CONCLUSION: A steep rise in the serum CRP level from POD 1 to POD 3 was a highly predictive factor for subsequent clinically relevant POPFs. PMID: 25024608 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Kanda M, Fujii T, Takami H, Suenaga M, Inokawa Y, Yamada S, Kobayashi D, Tanaka C, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y Tags: World J Gastroenterol Source Type: research

Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer.
CONCLUSION: Clobenpropit enhanced the anti-tumor effect of gemcitabine in pancreatic cancer cells through inhibition of the epithelial-mesenchymal transition process. PMID: 25024609 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Paik WH, Ryu JK, Jeong KS, Park JM, Song BJ, Lee SH, Kim YT, Yoon YB Tags: World J Gastroenterol Source Type: research

Changes in circulating Foxp3(+) regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure.
CONCLUSION: Treg and Th17 cells showed changes in genes, protein levels and T cell phenotypes during ACHBLF events. An increased Treg/Th17 ratio was associated with the survival of ACHBLF patients. PMID: 25024610 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Liang XS, Li CZ, Zhou Y, Yin W, Liu YY, Fan WH Tags: World J Gastroenterol Source Type: research

Zinc protoporphyrin IX enhances chemotherapeutic response of hepatoma cells to cisplatin.
CONCLUSION: ZnPP IX increases cellular sensitivity and susceptibility of liver cancer cell lines to CDDP and this may represent a mechanism of increasing ROS. PMID: 25024611 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Liu YS, Li HS, Qi DF, Zhang J, Jiang XC, Shi K, Zhang XJ, Zhang XH Tags: World J Gastroenterol Source Type: research

Prognostic significance of preoperative fibrinogen in patients with colon cancer.
CONCLUSION: Preoperative fibrinogen levels can serve as an independent prognostic marker to evaluate patient response to colon cancer treatment. PMID: 25024612 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Sun ZQ, Han XN, Wang HJ, Tang Y, Zhao ZL, Qu YL, Xu RW, Liu YY, Yu XB Tags: World J Gastroenterol Source Type: research

Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans.
CONCLUSION: All 5 tested tag SNPs of the PRKAA1 gene (rs13361707, rs154268, rs3805486, rs6882903, and rs10074991) were significantly associated with gastric cancer. PMID: 25024613 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Kim YD, Yim DH, Eom SY, Moon SI, Yun HY, Song YJ, Youn SJ, Hyun T, Park JS, Kim BS, Lee JY, Won HK, Kim H Tags: World J Gastroenterol Source Type: research

Endoscopic ultrasound-guided fine-needle aspiration for suspected malignancies adjacent to the gastrointestinal tract.
CONCLUSION: EUS-FNA can effectively detect a curable malignant lesions at an earlier time and at a higher rate in patients with a higher cancer risk that were evaluated using MTE. PMID: 25024614 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Gambitta P, Armellino A, Forti E, Vertemati M, Colombo PE, Aseni P Tags: World J Gastroenterol Source Type: research

Birthplace is not a determinant of colorectal adenomas.
CONCLUSION: Birthplace is not a predictor for developing colorectal neoplasia, including adenomas and advanced adenomas; hence, should not influence the recommendations for colorectal cancer screening. PMID: 25024615 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Tran F, Koo JH Tags: World J Gastroenterol Source Type: research

Follow-up of patients with pseudotumoral chronic pancreatitis: Outcome and surveillance.
CONCLUSION: According to characteristics of patient, detection of PCP should lead a surveillance program for pancreatic cancer with EUS-FNA in < 1 mo or directly to surgical resection. PMID: 25024616 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Téllez-Ávila FI, Villalobos-Garita A, Giovannini M, Chan C, Hernández-Calleros J, Uscanga L, Ramírez-Luna MÁ Tags: World J Gastroenterol Source Type: research

Need for pancreatic stenting after sphincterotomy in patients with difficult cannulation.
CONCLUSION: In patients with difficult cannulation in whom the bile duct is cannulated using P-GW, a pancreatic stent should be placed even if EST has been performed. PMID: 25024617 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Nakahara K, Okuse C, Suetani K, Michikawa Y, Kobayashi S, Otsubo T, Itoh F Tags: World J Gastroenterol Source Type: research

Selection of appropriate endoscopic therapies for duodenal tumors: An open-label study, single-center experience.
CONCLUSION: ESD was associated with a longer procedure time and a higher incidence of intraprocedural perforation; EMR was associated with a lower rate of complete resection. PMID: 25024618 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Matsumoto S, Yoshida Y Tags: World J Gastroenterol Source Type: research

Impact of tumor location on clinical outcomes of gastric endoscopic submucosal dissection.
CONCLUSION: More advanced endoscopic techniques are required during ESD for lesions located in the upper third or posterior wall of the stomach to decrease complications and improve therapeutic outcomes. PMID: 25024619 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Yoon JY, Shim CN, Chung SH, Park W, Chung H, Lee H, Shin SK, Lee SK, Lee YC, Park JC Tags: World J Gastroenterol Source Type: research

Outcomes of simple saline-coupled bipolar electrocautery for hepatic resection.
CONCLUSION: Simple saline-coupled BIP should be considered a safe and reliable technique for liver resection to decrease intraoperative hemorrhage and postoperative complications. PMID: 25024620 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Guo JY, Li DW, Liao R, Huang P, Kong XB, Wang JM, Wang HL, Luo SQ, Yan X, Du CY Tags: World J Gastroenterol Source Type: research

Lipid levels in serum and cancerous tissues of colorectal cancer patients.
CONCLUSION: The disordered and abnormally altered levels of lipids in cancerous tissue and serum of patients with colorectal cancer may be correlated with the occurrence and development of colorectal cancer. PMID: 25024621 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Zhang X, Zhao XW, Liu DB, Han CZ, Du LL, Jing JX, Wang Y Tags: World J Gastroenterol Source Type: research

Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy.
CONCLUSION: HPLC-based plasma profiling analysis was shown to be an effective approach to differentiate between ESCC patients and controls. PFAA profiles may have potential value for screening or diagnosing ESCC. PMID: 25024622 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Ma H, Hasim A, Mamtimin B, Kong B, Zhang HP, Sheyhidin I Tags: World J Gastroenterol Source Type: research

Outcomes of autologous bone marrow mononuclear cell transplantation in decompensated liver cirrhosis.
CONCLUSION: BM-MNCs transplantation is safe and effective in patients with decompensated cirrhosis. It also decreases the incidence of serious complications. PMID: 25024623 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Bai YQ, Yang YX, Yang YG, Ding SZ, Jin FL, Cao MB, Zhang YR, Zhang BY Tags: World J Gastroenterol Source Type: research

Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation.
CONCLUSION: Non-obese LT recipients have similar pro-atherosclerotic serum profiles after a short 1-year follow-up period compared to NASH patients, suggesting a high risk of atherosclerosis in this population. PMID: 25024624 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Alvares-da-Silva MR, de Oliveira CP, Stefano JT, Barbeiro HV, Barbeiro D, Soriano FG, Farias AQ, Carrilho FJ, Carneiro D'Albuquerque LA Tags: World J Gastroenterol Source Type: research

Combination of symptoms, syndrome and disease: Treatment of refractory diabetic gastroparesis.
CONCLUSION: Use of the combination of symptoms, syndrome and disease to treat diabetic gastroparesis with refractory nausea and vomiting may be a new treatment option. PMID: 25024625 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Li JL, Li M, Pang B, Zhou Q, Tian JX, Liu HX, Zhao XY, Tong XL Tags: World J Gastroenterol Source Type: research

Expression of P450 and nuclear receptors in normal and end-stage Chinese livers.
CONCLUSION: The expression of CYP enzyme genes and corresponding nuclear receptors was generally decreased in end-stage liver diseases, and significant differences in gene expression were evident between peri-HCC and HCC. PMID: 25024626 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Chen H, Shen ZY, Xu W, Fan TY, Li J, Lu YF, Cheng ML, Liu J Tags: World J Gastroenterol Source Type: research

Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy.
CONCLUSION: DFA1 ≥ 1200 U/L is an important predictive factor for PF of any degree. The trend of DFA3 (decrease of < 50%) compared to DFA1 is a significant factor in the differentiation of CRPF from transient BPF. PMID: 25024627 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Dugalic VD, Knezevic DM, Obradovic VN, Gojnic-Dugalic MG, Matic SV, Pavlovic-Markovic AR, Dugalic PD, Knezevic SM Tags: World J Gastroenterol Source Type: research

APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans.
CONCLUSION: APE1 Asp148Glu is associated with increased CRC risk and smoking alters the association between XRCC1 Arg399Gln and CRC risk in the Chinese Han population. PMID: 25024628 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Zhang SH, Wang LA, Li Z, Peng Y, Cun YP, Dai N, Cheng Y, Xiao H, Xiong YL, Wang D Tags: World J Gastroenterol Source Type: research

I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life.
CONCLUSION: A new combination of three different probiotic bacteria was superior to placebo in improving IBS-related quality of life in patients with IBS and diarrhea. PMID: 25024629 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Lorenzo-Zúñiga V, Llop E, Suárez C, Alvarez B, Abreu L, Espadaler J, Serra J Tags: World J Gastroenterol Source Type: research

Acute abdomen: Rare and unusual presentation of right colic xanthogranulomatosis.
We report the case of a 56-year-old woman presenting to the Emergency Department with pain, increased levels of α1 and α2 proteins and C-reactive protein (17.5 mg/dL; normal value 0-0.5), and a palpable mass, localized in the right lower quadrant of the abdomen. A computed tomography scan showed a large right cecal mass with necrotic areas, local inflammation of retroperitoneal fat, and enlargement of local lymph nodes. Because of the high suspicion of colic abscess as well as malignancy and worsening of the clinical condition, the patient underwent right colectomy after 4 d of antibiotic treatment. Pathology revealed xa...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Addario Chieco P, Antolino L, Giaccaglia V, Centanini F, Cunsolo GV, Sparagna A, Uccini S, Ziparo V Tags: World J Gastroenterol Source Type: research

HBsAg clearance by Peg-interferon addition to a long-term nucleos(t)ide analogue therapy.
Abstract The ideal endpoint of hepatitis B virus (HBV) antiviral therapy is HBsAg loss, a difficult goal to obtain, especially in HBeAg negative patients. Herein, we report the results obtained by the addition of peg-interferon α-2a to a long-lasting nucleos(t)ide analogue therapy in a HBeAg negative, genotype D patient with steadily HBV-DNA negative/HBsAg positive values. In 2002, our Caucasian 44-year-old male patient received lamivudine and, 4 years later, added adefovir because of a virological breakthrough. In 2011, considering his young age, liver stiffness (4.3 kPa) and HBsAg levels (3533 IU/mL), we added P...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Barone M, Iannone A, Di Leo A Tags: World J Gastroenterol Source Type: research

Perihepatic adhesions: An unusual complication of hemolysis, elevated liver enzymes and low platelet syndrome.
We present a case of symptomatic perihepatic adhesions, which developed after a pregnancy complicated by hemolysis, elevated liver enzymes and low platelet (HELLP) syndrome, in which a subcapsular liver hematoma occurred. Our patient presented with complaints of persistent, severe right-sided upper abdominal pain. The complaints developed gradually, one year after a pregnancy that had been complicated by HELLP syndrome with a subcapsular liver hematoma. The hematoma had resolved spontaneously. An upper-abdominal magnetic resonance imaging revealed a density between liver and diaphragm at the site of the former subcapsular ...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Koeneman MM, Koek GH, Bemelmans M, Peeters LL Tags: World J Gastroenterol Source Type: research

Two-stage treatment with hepatectomy and carbon-ion radiotherapy for multiple hepatic epithelioid hemangioendotheliomas.
We describe a case of a 35-year-old woman with unresectable multiple bilobar HEH successfully treated by combination treatment with hepatectomy and carbon-ion radiotherapy. This case is very meaningful since it demonstrated the effectiveness of carbon-ion radiotherapy for HEH and the possibility of expanding the curative treatment options for multiple bilobar hepatic tumors. PMID: 25024633 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Komatsu S, Iwasaki T, Demizu Y, Terashima K, Fujii O, Takebe A, Toyokawa A, Teramura K, Fukumoto T, Ku Y, Fuwa N Tags: World J Gastroenterol Source Type: research

Tubulopapillary adenoma of the gallbladder accompanied by bile duct tumor thrombus.
We present here a case of IPNB arising from the gallbladder accompanied by bile duct tumor thrombus in a 79-year-old female. The resected specimen revealed a tubulopapillary adenoma with no malignant cells. This case suggests that even in the absence of malignant cells, these tumors can behave as malignant tumors requiring aggressive treatment. Even if no malignant cells are present, intraepithelial neoplasms occurring in the ampullopancreatobiliary tract can behave as malignant tumors. PMID: 25024634 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Yamamoto K, Yamamoto F, Maeda A, Igimi H, Yamamoto M, Yamaguchi R, Yamashita Y Tags: World J Gastroenterol Source Type: research

First case of IgG4-related sclerosing cholangitis associated with autoimmune hemolytic anemia.
We describe our experience with a patient who had IgG4-SC without AIP in whom the presence of AIHA led to diagnosis. The patient was a 73-year-old man who was being treated for dementia. Liver dysfunction was diagnosed on blood tests at another hospital. Imaging studies suggested the presence of carcinoma of the hepatic hilus and primary sclerosing cholangitis, but a rapidly progressing anemia developed simultaneously. After the diagnosis of AIHA, steroid treatment was begun, and the biliary stricture improved. IgG4-SC without AIP was thus diagnosed. PMID: 25024635 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Masutani H, Okuwaki K, Kida M, Yamauchi H, Imaizumi H, Miyazawa S, Iwai T, Takezawa M, Koizumi W Tags: World J Gastroenterol Source Type: research

Laparoscopic segmental colectomy for colonic lymphangiomas: A definitive, minimally invasive surgical option.
Abstract Colonic lymphangioma is an unusual benign malformation. We herein describe two cases. A 36-year-old woman was admitted with one year of intermittent abdominal pain; colonoscopy, abdominopelvic computed tomography and endoscopic ultrasonography (EUS) revealed enlarged cystic masses at the ascending colon. In another 40-year-old man, colonoscopy and EUS revealed an asymptomatic lobulated cystic mass with four small sessile polyps at the sigmoid colon. Both patients underwent laparoscopic segmental colectomy. Both masses were histologically confirmed as cystic lymphangiomas, and the patients were discharged w...
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Zhuo CH, Shi DB, Ying MG, Cheng YF, Wang YW, Zhang WM, Cai SJ, Li XX Tags: World J Gastroenterol Source Type: research

Prospects for inhibiting the post-transcriptional regulation of gene expression in hepatitis B virus.
Abstract There is a continuing need for novel antivirals to treat hepatitis B virus (HBV) infection, as it remains a major health problem worldwide. Ideally new classes of antivirals would target multiple steps in the viral lifecycle. In this review, we consider the steps in which HBV RNAs are processed, exported from the nucleus and translated. These are often overlooked steps in the HBV life-cycle. HBV, like retroviruses, incorporates a number of unusual steps in these processes, which use a combination of viral and host cellular machinery. Some of these unusual steps deserve a closer scrutiny. They may provide a...
Source: World Journal of Gastroenterology : WJG - July 7, 2014 Category: Gastroenterology Authors: Chen A, Panjaworayan T-Thienprasert N, Brown CM Tags: World J Gastroenterol Source Type: research

Peculiar characteristics of portal-hepatic hemodynamics of alcoholic cirrhosis.
Abstract Alcohol-related cirrhosis is a consequence of heavy and prolonged drinking. Similarly to patients with cirrhosis of other etiologies, patients with alcoholic cirrhosis develop portal hypertension and the hepatic, splanchnic and systemic hemodynamic alterations that follow. However, in alcoholic cirrhosis, some specific features can be observed. Compared to viral cirrhosis, in alcohol-related cirrhosis sinusoidal pressure is generally higher, hepatic venous pressure gradient reflects portal pressure better, the portal flow perfusing the liver is reduced despite an increase in liver weight, the prevalence of...
Source: World Journal of Gastroenterology : WJG - July 7, 2014 Category: Gastroenterology Authors: Bolognesi M, Verardo A, Di Pascoli M Tags: World J Gastroenterol Source Type: research

Extracorporeal liver support in severe alcoholic hepatitis.
Abstract The severity of alcoholic hepatitis (AH) which may coexist with cirrhosis varies greatly, from asymptomatic forms which are detected in alcoholic patients without any sign of liver disease, except laboratory abnormalities, to severe forms characterised by deep jaundice, ascites, hepatic encephalopathy and low prothrombin index. In hospitalized patients the mortality could be as high as 75%. The elevated number of therapeutic proposals reported for more than forty years reveals the lack of efficacy of a particular modality. Even in the most favorable trials, the survival is already very poor and in some cas...
Source: World Journal of Gastroenterology : WJG - July 7, 2014 Category: Gastroenterology Authors: Parés A, Mas A Tags: World J Gastroenterol Source Type: research

Liver fibrosis markers in alcoholic liver disease.
Abstract Alcohol is one of the main factors of liver damage. The evaluation of the degree of liver fibrosis is of great value for therapeutic decision making in patients with alcoholic liver disease (ALD). Staging of liver fibrosis is essential to define prognosis and management of the disease. Liver biopsy is a gold standard as it has high sensitivity and specificity in fibrosis diagnostics. Taking into account the limitations of liver biopsy, there is an exigency to introduce non-invasive serum markers for fibrosis that would be able to replace liver biopsy. Ideal serum markers should be specific for the liver, e...
Source: World Journal of Gastroenterology : WJG - July 7, 2014 Category: Gastroenterology Authors: Chrostek L, Panasiuk A Tags: World J Gastroenterol Source Type: research

Diagnostic challenges in alcohol use disorder and alcoholic liver disease.
Abstract Alcohol use disorders represent a heterogeneous spectrum of clinical manifestations that have been defined by the Diagnostic and Statistical Manual of Mental Disorders-5. Excessive alcohol intake can lead to damage of various organs, including the liver. Alcoholic liver disease includes different injuries ranging from steatosis to cirrhosis and implicates a diagnostic assessment of the liver disease and of its possible complications. There is growing interest in the possible different tools for assessing previous alcohol consumption and for establishing the severity of liver injury, especially by non-invas...
Source: World Journal of Gastroenterology : WJG - July 7, 2014 Category: Gastroenterology Authors: Vonghia L, Michielsen P, Dom G, Francque S Tags: World J Gastroenterol Source Type: research