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Crohn's disease presenting as acute gastrointestinal hemorrhage.
Abstract Severe gastrointestinal (GI) hemorrhage is a rare complication of Crohn's disease (CD). Although several surgical and non-surgical approaches have been described over the last 2 decades this complication still poses significant diagnostic and therapeutic challenges. Given the relative infrequency of severe bleeding in CD, available medical literature on this topic is mostly in the form of retrospective case series and reports. In this article we review the risk factors, diagnostic modalities and treatment options for the management of CD presenting as GI hemorrhage. PMID: 27122659 [PubMed - in process...
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Podugu A, Tandon K, Castro FJ Tags: World J Gastroenterol Source Type: research

Nonalcoholic fatty liver disease as a multi-systemic disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. NAFLD includes a wide spectrum of liver conditions ranging from simple steatosis to nonalcoholic steatohepatitis and advanced hepatic fibrosis. NAFLD has been recognized as a hepatic manifestation of metabolic syndrome linked with insulin resistance. NAFLD should be considered not only a liver specific disease but also an early mediator of systemic diseases. Therefore, NAFLD is usually associated with cardiovascular disease, chronic kidney disease, type 2 diabetes, obesity, and dyslipidemia. NAFLD is highly prevalen...
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Fotbolcu H, Zorlu E Tags: World J Gastroenterol Source Type: research

Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease.
CONCLUSION: We describe a new 12-wk HCC model in adult mice that develops in livers with alcoholic hepatitis and defines ALD as co-factor in HCC. PMID: 27122661 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Ambade A, Satishchandran A, Gyongyosi B, Lowe P, Szabo G Tags: World J Gastroenterol Source Type: research

Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines.
CONCLUSION: The data indicate that the basic impact of a genotype might be characterized by analysis of mutant hepatic cell lines. PMID: 27122662 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Chandhok G, Horvath J, Aggarwal A, Bhatt M, Zibert A, Schmidt HH Tags: World J Gastroenterol Source Type: research

Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy.
CONCLUSION: MSCs and IL-1Ra had a synergistic effect in liver regeneration via regulation of inflammation and apoptotic signaling. PMID: 27122663 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Sang JF, Shi XL, Han B, Huang X, Huang T, Ren HZ, Ding YT Tags: World J Gastroenterol Source Type: research

Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats.
CONCLUSION: This study identifies that the protective efficacy of Ad-HGF-HIL-6 is more potent than that of Ad-HGF or Ad-HIL-6 in ACLF rats, with no significant side effects. PMID: 27122664 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Gao DD, Fu J, Qin B, Huang WX, Yang C, Jia B Tags: World J Gastroenterol Source Type: research

Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro.
CONCLUSION: This study provides strong evidence that downregulation of the STAT3 signaling pathway mediates TQ-induced apoptosis in gastric cancer. PMID: 27122665 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Zhu WQ, Wang J, Guo XF, Liu Z, Dong WG Tags: World J Gastroenterol Source Type: research

Total pancreatectomy with islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis.
CONCLUSION: ITNP and TP + ICT are comparable for pain control in patients with CP however with high incidence of DM among those who underwent TP + ICT. Prospective comparative studies and longer follow up are needed to better define treatment outcomes. PMID: 27122666 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Mokadem M, Noureddine L, Howard T, McHenry L, Sherman S, Fogel EL, Watkins JL, Lehman GA Tags: World J Gastroenterol Source Type: research

Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model.
CONCLUSION: Our proposed mathematical model may be a useful method for the early detection of different statuses of liver disease co-occurring with HCV infection. PMID: 27122667 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Zekri AR, Youssef AS, Bakr YM, Gabr RM, Ahmed OS, Elberry MH, Mayla AM, Abouelhoda M, Bahnassy AA Tags: World J Gastroenterol Source Type: research

Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort.
CONCLUSION: The gene-environment interaction between the KIF1B rs17401966 variant and alcohol consumption may contribute to the development of HCC in Chinese individuals. PMID: 27122668 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Chen JH, Wang YY, Lv WB, Gan Y, Chang W, Tian NN, Huang XH, Liu L, Yu XF, Chen SD Tags: World J Gastroenterol Source Type: research

Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study.
CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. PMID: 27122669 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Cox IJ, Aliev AE, Crossey MM, Dawood M, Al-Mahtab M, Akbar SM, Rahman S, Riva A, Williams R, Taylor-Robinson SD Tags: World J Gastroenterol Source Type: research

Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor.
CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. PMID: 27122670 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Friedrich-Rust M, Wanger B, Heupel F, Filmann N, Brodt R, Kempf VA, Kessel J, Wichelhaus TA, Herrmann E, Zeuzem S, Bojunga J Tags: World J Gastroenterol Source Type: research

Lymphocyte-to-monocyte ratio predicts survival after radiofrequency ablation for colorectal liver metastases.
CONCLUSION: Our study provides support for the use of LMR as a novel predictor of outcome for CLM patients. PMID: 27122671 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Facciorusso A, Del Prete V, Crucinio N, Serviddio G, Vendemiale G, Muscatiello N Tags: World J Gastroenterol Source Type: research

Predictors of poor outcome in gastrointestinal bleeding in emergency department.
CONCLUSION: Prognostic factors for gastrointestinal bleeding in emergency room cases are malignancy, hypotension on admission, low GCS, and impaired kidney function. PMID: 27122672 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Kaya E, Karaca MA, Aldemir D, Ozmen MM Tags: World J Gastroenterol Source Type: research

Eukaryotic elongation factor-1α 2 knockdown inhibits hepatocarcinogenesis by suppressing PI3K/Akt/NF-κB signaling.
CONCLUSION: eEF1A2, highly expressed in HCC, is a potential oncogene. Its silencing significantly decreases HCC tumorigenesis, likely by inhibiting PI3K/Akt/NF-κB signaling. PMID: 27122673 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Qiu FN, Huang Y, Chen DY, Li F, Wu YA, Wu WB, Huang XL Tags: World J Gastroenterol Source Type: research

Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?
CONCLUSION: TE appears reliable in distinguishing different stages of liver fibrosis in children. However, its values vary according to the disease type. For that, a disease-specific estimation of cut-off values for fibrosis staging is worthy. PMID: 27122674 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Behairy Bel-S, Sira MM, Zalata KR, Salama el-SE, Abd-Allah MA Tags: World J Gastroenterol Source Type: research

Predictive effects of bilirubin on response of colorectal cancer to irinotecan-based chemotherapy.
CONCLUSION: CoBil and UGT1A1*28 are both independent biomarkers for predicting the treatment response of mCRC patients to irinotecan-based chemotherapy. After validation, CoBil, an easily determinable index in the clinic, might be helpful in facilitating stratification of mCRC patients for individualized treatment options. PMID: 27122675 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Yu QQ, Qiu H, Zhang MS, Hu GY, Liu B, Huang L, Liao X, Li QX, Li ZH, Yuan XL Tags: World J Gastroenterol Source Type: research

Pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion from an aortic intramural hematoma.
Abstract Pancreaticoduodenal artery aneurysms are a rare type of visceral artery aneurysm, whose rupture is associated with high mortality. These aneurysms are of particular interest because local haemodynamic change caused by coeliac artery obstruction plays an important role in their development. However, the pathophysiological mechanism of coeliac artery obstruction is not completely understood. Pressure from the median arcuate ligament is most frequently reported cause. Although it is well-known that stenosis or occlusion of the visceral vessels may be caused by aortic syndrome, reports of pancreaticoduodenal a...
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Sakatani A, Doi Y, Kitayama T, Matsuda T, Sasai Y, Nishida N, Sakamoto M, Uenoyama N, Kinoshita K Tags: World J Gastroenterol Source Type: research

Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis.
Abstract Acute obstructive suppurative cholangitis (AOSC) due to biliary lithiasis is a life-threatening condition that requires urgent biliary decompression. Although endoscopic retrograde cholangiopancreatography (ERCP) with stent placement is the current gold standard for biliary decompression, it can sometimes be difficult because of failed biliary cannulation. In this retrospective case series, we describe three cases of successful biliary drainage with recovery from septic shock after urgent endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) was performed for AOSC due to biliary lithiasis. In all t...
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Minaga K, Kitano M, Imai H, Yamao K, Kamata K, Miyata T, Omoto S, Kadosaka K, Yoshikawa T, Kudo M Tags: World J Gastroenterol Source Type: research

Occult gastric cancer with distant metastasis proven by random gastric biopsy.
Abstract Krukenberg tumor, a rare metastatic ovarian tumor arising from gastrointestinal adenocarcinoma mainly, tends to occur in premenopausal females. Finding the origin of a Krukenberg tumor is crucial for determining prognosis. In Eastern countries, the most common origin of Krukenberg tumor is stomach cancer, which is generally diagnosed via endoscopic biopsy to investigate an abnormal mucosal lesion. Here, we describe a case of huge adnexal mass in a 33-year-old woman who presented with abdominal distension. Two independent endoscopic examinations performed by experts in two tertiary university hospitals reve...
Source: World Journal of Gastroenterology : WJG - April 28, 2016 Category: Gastroenterology Authors: Lee SH, Lim KH, Song SY, Lee HY, Park SC, Kang CD, Lee SJ, Choi DW, Park SB, Ryu YJ Tags: World J Gastroenterol Source Type: research

Advances in local ablation of malignant liver lesions.
Abstract Local ablation of liver tumors matured during the recent years and is now proven to be an effective tool in the treatment of malignant liver lesions. Advances focus on the improvement of local tumor control by technical innovations, individual selection of imaging modalities, more accurate needle placement and the free choice of access to the liver. Considering data found in the current literature for conventional local ablative treatment strategies, virtually no single technology is able to demonstrate an unequivocal superiority. Hints at better performance of microwave compared to radiofrequency ablation...
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Eisele RM Tags: World J Gastroenterol Source Type: research

New treatment options for alcoholic hepatitis.
Abstract The burden of alcoholic liver disease has rapidly grown in the past two decades and is expected to increase further in the coming years. Alcoholic hepatitis, the most florid presentation of alcoholic liver disease, continues to have high morbidity and mortality, with significant financial and healthcare burden with limited treatment options. Steroids remain the current standard of care in severe alcoholic hepatitis in carefully selected patients. No specific treatments are available for those patients who are steroid ineligible, intolerant or unresponsive. Liver transplant has shown good short-term outcome...
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Shasthry SM, Sarin SK Tags: World J Gastroenterol Source Type: research

MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B- and C-related-hepatocellular-carcinoma.
Abstract Aim of the present review is to summarize the current knowledge about the potential relationship between miRNAs and hepatitis B virus (HBV)-hepatitis C virus (HCV) related liver diseases. A systematic computer-based search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine miRNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma (HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headi...
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Fiorino S, Bacchi-Reggiani ML, Visani M, Acquaviva G, Fornelli A, Masetti M, Tura A, Grizzi F, Zanello M, Mastrangelo L, Lombardi R, Di Tommaso L, Bondi A, Sabbatani S, Domanico A, Fabbri C, Leandri P, Pession A, Jovine E, de Biase D Tags: World J Gastroenterol Source Type: research

Missing metastases as a model to challenge current therapeutic algorithms in colorectal liver metastases.
Abstract In oncosurgical approach to colorectal liver metastases, surgery remains considered as the only potentially curative option, while chemotherapy alone represents a strictly palliative treatment. However, missing metastases, defined as metastases disappearing after chemotherapy, represent a unique model to evaluate the curative potential of chemotherapy and to challenge current therapeutic algorithms. We reviewed recent series on missing colorectal liver metastases to evaluate incidence of this phenomenon, predictive factors and rates of cure defined by complete pathologic response in resected missing metast...
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Lucidi V, Hendlisz A, Van Laethem JL, Donckier V Tags: World J Gastroenterol Source Type: research

Technical tips for endoscopic ultrasound-guided hepaticogastrostomy.
Abstract Interventional procedures using endoscopic ultrasound (EUS) have recently been developed. For biliary drainage, EUS-guided trans-luminal drainage has been reported. In this procedure, the transduodenal approach for extrahepatic bile ducts is called EUS-guided choledochoduodenostomy, and the transgastric approach for intrahepatic bile ducts is called EUS-guided hepaticogastrostomy (EUS-HGS). These procedures have several effects, such as internal drainage and avoiding post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, and they are indicated for an inaccessible ampulla of Vater due to d...
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Ogura T, Higuchi K Tags: World J Gastroenterol Source Type: research

Gallic acid induced apoptotic events in HCT-15 colon cancer cells.
CONCLUSION: These results show that GA induced ROS dependent apoptosis and inhibited the growth of colon cancer cells. PMID: 27099438 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Subramanian AP, Jaganathan SK, Mandal M, Supriyanto E, Muhamad II Tags: World J Gastroenterol Source Type: research

Norcantharidin combined with ABT-737 for hepatocellular carcinoma: Therapeutic effects and molecular mechanisms.
CONCLUSION: NCTD combined with ABT-737 has a positive role in the treatment of HCC, and it has great value in clinical research. PMID: 27099439 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Ren J, Li G, Zhao W, Lin L, Ye T Tags: World J Gastroenterol Source Type: research

Integrin-linked kinase overexpression promotes epithelial-mesenchymal transition via nuclear factor-κB signaling in colorectal cancer cells.
CONCLUSION: ILK overexpression improved the proliferation, metastasis, and invasion ability of SW480 cells, and this effect may be mediated by the NF-κB signaling pathway. PMID: 27099440 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Shen H, Ma JL, Zhang Y, Deng GL, Qu YL, Wu XL, He JX, Zhang S, Zeng S Tags: World J Gastroenterol Source Type: research

Mir-30d increases intracellular survival of Helicobacter pylori through inhibition of autophagy pathway.
CONCLUSION: Mir-30d increases intracellular survival of H. pylori in gastric epithelial cells through inhibition of multiple core proteins in the autophagy pathway. PMID: 27099441 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Yang XJ, Si RH, Liang YH, Ma BQ, Jiang ZB, Wang B, Gao P Tags: World J Gastroenterol Source Type: research

CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells.
CONCLUSION: CacyBP/SIP nuclear translocation contributes to the proliferation of GC cells, and CacyBP/SIP exerts this effect, at least in part, by stimulating ubiquitin-mediated degradation of p27Kip1. PMID: 27099442 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Niu YL, Li YJ, Wang JB, Lu YY, Liu ZX, Feng SS, Hu JG, Zhai HH Tags: World J Gastroenterol Source Type: research

Socio-economic status and lifestyle factors are associated with achalasia risk: A population-based case-control study.
CONCLUSION: Achalasia is a disease of inequality, and individuals from low socio-economic backgrounds are at highest risk. This does not appear to be due to corresponding alcohol and smoking behaviours. An observed positive association between pet ownership and achalasia risk suggests an interaction between endotoxin and viral infection exposure in achalasia aetiology. PMID: 27099443 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Coleman HG, Gray RT, Lau KW, McCaughey C, Coyle PV, Murray LJ, Johnston BT Tags: World J Gastroenterol Source Type: research

Follow-up of patients with functional bowel symptoms treated with a low FODMAP diet.
CONCLUSION: These data suggest that a diet low in FODMAPs is an efficacious treatment solution in the management of functional bowel symptoms for IBS and IBD patients. PMID: 27099444 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Maagaard L, Ankersen DV, Végh Z, Burisch J, Jensen L, Pedersen N, Munkholm P Tags: World J Gastroenterol Source Type: research

Risk of lymph node metastasis in mixed-type early gastric cancer determined by the extent of the poorly differentiated component.
CONCLUSION: We recommend careful identification and quantitative evaluation of mixed-type early gastric cancer components after endoscopic resection to determine the intensity of the treatment. PMID: 27099445 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Hwang CS, Ahn S, Lee BE, Lee SJ, Kim A, Choi CI, Kim DH, Jeon TY, Kim GH, Song GA, Park do Y Tags: World J Gastroenterol Source Type: research

Intestinal histoplasmosis in immunocompetent adults.
CONCLUSION: Immunocompetent individuals suffering from histoplasmosis are rarely reported. It is necessary that gastroenterologists and endoscopists consider histoplasmosis as a differential diagnosis, even in immunocompetent patients. PMID: 27099446 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Zhu LL, Wang J, Wang ZJ, Wang YP, Yang JL Tags: World J Gastroenterol Source Type: research

Sorafenib after resection improves the outcome of BCLC stage C hepatocellular carcinoma.
CONCLUSION: Sorafenib after SR was well-tolerated. Patients who received sorafenib after SR had better outcomes compared to patients who received only SR. PMID: 27099447 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Li J, Hou Y, Cai XB, Liu B Tags: World J Gastroenterol Source Type: research

Worldwide practice in gastric cancer surgery.
CONCLUSION: Surgical preferences for gastric cancer surgery vary between surgeons worldwide. Although the majority of surgeons use neoadjuvant chemotherapy, minimally invasive techniques are still not widely adapted. PMID: 27099448 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Brenkman HJ, Haverkamp L, Ruurda JP, van Hillegersberg R Tags: World J Gastroenterol Source Type: research

Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia.
CONCLUSION: XDR bacteria are an independent life-threatening factor in SBP/SB. Strategies aiming at restricting antibiotic overuse and rapid identification of the responsible bacteria could help improve survival. PMID: 27099449 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Alexopoulou A, Vasilieva L, Agiasotelli D, Siranidi K, Pouriki S, Tsiriga A, Toutouza M, Dourakis SP Tags: World J Gastroenterol Source Type: research

Nasogastric tube syndrome induced by an indwelling long intestinal tube.
We report a case of a 76-year-old man with NTS, induced by an indwelling long intestinal tube. He was admitted to our hospital for treatment of sigmoid colon cancer. He underwent sigmoidectomy to release a bowel obstruction, and had a long intestinal tube inserted to decompress the intestinal tract. He presented acute dyspnea following prolonged intestinal intubation, and bronchoscopy showed bilateral vocal cord paralysis. The NGT was removed immediately, and tracheotomy was performed. The patient was finally discharged in a fully recovered state. NTS be considered in patients complaining of acute upper airway obstruction,...
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Sano N, Yamamoto M, Nagai K, Yamada K, Ohkohchi N Tags: World J Gastroenterol Source Type: research

Atypical onset of bicalutamide-induced liver injury.
Abstract Anti-androgen therapy is the leading treatment for advanced prostate cancer and is commonly used for neoadjuvant or adjuvant treatment. Bicalutamide is a non-steroidal anti-androgen, used during the initiation of androgen deprivation therapy along with a luteinizing hormone-releasing hormone agonist to reduce the symptoms of tumor-related flares in patients with advanced prostate cancer. As side effects, bicalutamide can cause fatigue, gynecomastia, and decreased libido through competitive androgen receptor blockade. Additionally, although not as common, drug-induced liver injury has also been reported. He...
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Yun GY, Kim SH, Kim SW, Joo JS, Kim JS, Lee ES, Lee BS, Kang SH, Moon HS, Sung JK, Lee HY, Kim KH Tags: World J Gastroenterol Source Type: research

Gastric inverted hyperplastic polyp: A rare cause of iron deficiency anemia.
Abstract Gastric inverted hyperplastic polyp (IHP) is a rare gastric polyp characterized by the downward growth of hyperplastic mucosal components into the submucosal layer. Macroscopically, a gastric IHP resembles a subepithelial tumor (SET); as a result, accurately diagnosing gastric IHP is difficult. This issue has clinical significance because gastric IHP can be misdiagnosed as SET or as malignant neoplasm In addition, adenocarcinoma can accompany benign gastric IHP. Although in most cases, gastric IHPs are asymptomatic and are found incidentally, these polyps may cause anemia secondary to chronic bleeding. Her...
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Yun JT, Lee SW, Kim DP, Choi SH, Kim SH, Park JK, Jang SH, Park YJ, Sung YG, Sul HJ Tags: World J Gastroenterol Source Type: research

Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication.
Abstract We read the article "Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori (H. pylori) eradication: A prospective single-center study from China" written by Wang et al with great interest. It is reported in American and European guidelines that there is no sufficient test for the diagnosis of H. pylori except culture and that using at least two different tests for diagnosis of H. pylori is recommended. Patients who used antibiotics or bismuth salts in the previous 2 wk were excluded from study. But patients who used probiotics and antioxidant vitamins such as vitamins ...
Source: World Journal of Gastroenterology : WJG - April 21, 2016 Category: Gastroenterology Authors: Demirci H, Ozturk K, Kurt O Tags: World J Gastroenterol Source Type: research

From prolonging life to prolonging working life: Tackling unemployment among liver-transplant recipients.
Abstract Return to active and productive life is a key goal of modern liver transplantation (LT). Despite marked improvements in quality of life and functional status, a substantial proportion of LT recipients are unable to resume gainful employment. Unemployment forms a threat to physical and psychosocial health, and impairs LT cost-utility through lost productivity. In studies published after year 2000, the average post-LT employment rate is 37%, ranging from 22% to 55% by study. Significant heterogeneity exists among studies. Nonetheless, these employment rates are lower than in the general population and kidney...
Source: World Journal of Gastroenterology : WJG - April 14, 2016 Category: Gastroenterology Authors: Åberg F Tags: World J Gastroenterol Source Type: research

Elastography for the pancreas: Current status and future perspective.
Abstract Elastography for the pancreas can be performed by either ultrasound or endoscopic ultrasound (EUS). There are two types of pancreatic elastographies based on different principles, which are strain elastography and shear wave elastography. The stiffness of tissue is estimated by measuring the grade of strain generated by external pressure in the former, whereas it is estimated by measuring propagation speed of shear wave, the transverse wave, generated by acoustic radiation impulse (ARFI) in the latter. Strain elastography is difficult to perform when the probe, the pancreas and the aorta are not located in...
Source: World Journal of Gastroenterology : WJG - April 14, 2016 Category: Gastroenterology Authors: Kawada N, Tanaka S Tags: World J Gastroenterol Source Type: research

Biomarkers for detection of alcohol consumption in liver transplantation.
Abstract Alcoholic liver disease is an established, yet controversial, indication for liver transplantation. Although an abstinence period of up to 6 mo prior to transplantation is mandatory, alcohol relapse after transplantation is a common event. In case of recurrence of heavy drinking, graft survival is significantly impaired. Guidelines on detection and surveillance of alcohol consumption in this patient cohort are lacking. This review summarizes the challenge of patient selection as well as the current knowledge on established and novel alcohol biomarkers with special focus on liver transplant candidates and r...
Source: World Journal of Gastroenterology : WJG - April 14, 2016 Category: Gastroenterology Authors: Staufer K, Yegles M Tags: World J Gastroenterol Source Type: research

Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease.
CONCLUSION: PTEN protein expression is downregulated early in NAFLD, but not in ALD. PTEN immunohistochemical detection could help in the differential diagnosis of NAFLD and ALD. PMID: 27076758 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2016 Category: Gastroenterology Authors: Sanchez-Pareja A, Clément S, Peyrou M, Spahr L, Negro F, Rubbia-Brandt L, Foti M Tags: World J Gastroenterol Source Type: research

S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.
CONCLUSION: A likely mechanism(s) by which SAM diminish HCV expression could involve modulating antioxidant enzymes, restoring biosynthesis of glutathione and switching MAT1/MAT2 turnover in HCV expressing cells. PMID: 27076759 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2016 Category: Gastroenterology Authors: Lozano-Sepulveda SA, Bautista-Osorio E, Merino-Mascorro JA, Varela-Rey M, Muñoz-Espinosa LE, Cordero-Perez P, Martinez-Chantar ML, Rivas-Estilla AM Tags: World J Gastroenterol Source Type: research

Evaluation of therapeutic effectiveness of (131)I-antiEGFR-BSA-PCL in a mouse model of colorectal cancer.
CONCLUSION: This study demonstrated the potential beneficial application of (131)I-antiEGFR-BSA-PCL for treating colorectal cancer. (131)I-antiEGFR-BSA-PCL suppressed the development of xenografted colorectal cancer in nude mice, thereby providing a novel candidate for receptor-mediated targeted radiotherapy. PMID: 27076760 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2016 Category: Gastroenterology Authors: Li W, Ji YH, Li CX, Liu ZY, Li N, Fang L, Chang J, Tan J Tags: World J Gastroenterol Source Type: research

Hypothalamic paraventricular nucleus stimulation reduces intestinal injury in rats with ulcerative colitis.
CONCLUSION: Chemical stimulation of the hypothalamic PVN provides a protective effect against UC injury in rats. Hypothalamic PVN, NTS and vagus nerve play key roles in this process. PMID: 27076761 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2016 Category: Gastroenterology Authors: Deng QJ, Deng DJ, Che J, Zhao HR, Yu JJ, Lu YY Tags: World J Gastroenterol Source Type: research

Multi-locus genetic risk score predicts risk for Crohn's disease in Slovenian population.
CONCLUSION: The authors proved the possibility of building accurate genetic risk score based on 33 risk variants on Slovenian CD patients which may serve as a screening tool in the targeted population. PMID: 27076762 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2016 Category: Gastroenterology Authors: Zupančič K, Skok K, Repnik K, Weersma RK, Potočnik U, Skok P Tags: World J Gastroenterol Source Type: research

Characteristics and outcomes of chronic liver disease patients with acute deteriorated liver function by severity of underlying liver disease.
CONCLUSION: There were clear differences in predisposition, type of injury, accompanying organ failure and long-term mortality according to spectrum of chronic liver disease, implying classifying subtype according to the severity of underlying liver disease is useful for defining, clarifying and comparing ACLF. PMID: 27076763 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2016 Category: Gastroenterology Authors: Hong YS, Sinn DH, Gwak GY, Cho J, Kang D, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW Tags: World J Gastroenterol Source Type: research