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Gut microbiota and liver diseases.
Abstract Several studies revealed that gut microbiota are associated with various human diseases, e.g., metabolic diseases, allergies, gastroenterological diseases, and liver diseases. The liver can be greatly affected by changes in gut microbiota due to the entry of gut bacteria or their metabolites into the liver through the portal vein, and the liver-gut axis is important to understand the pathophysiology of several liver diseases, especially non-alcoholic fatty liver disease and hepatic encephalopathy. Moreover, gut microbiota play a significant role in the development of alcoholic liver disease and hepatocarci...
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Minemura M, Shimizu Y Tags: World J Gastroenterol Source Type: research

Robotic assisted Roux-en-Y hepaticojejunostomy in a post-cholecystectomy type E2 bile duct injury.
We present a case of 36-year-old female patient who had undergone elective cholecystectomy 2 mo ago for gall stones and had a common bile duct injury during surgery. As the stricture was old and complete it could not be tackled endoscopically. We did a laparoscopic assisted adhesiolysis followed by robotic Roux-en-Y hepaticojejunostomy. No intraoperative complications or technical problems were encountered. Postoperative period was uneventful and she was discharged on the 4(th) postoperative day. At follow-up, she is doing well without evidence of jaundice or cholangitis. This is the first reported case of robotic hepatico...
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Prasad A, De S, Mishra P, Tiwari A Tags: World J Gastroenterol Source Type: research

Pancreatic cancer early detection: Expanding higher-risk group with clinical and metabolomics parameters.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the fourth and fifth leading cause of cancer death for each gender in developed countries. With lack of effective treatment and screening scheme available for the general population, the mortality rate is expected to increase over the next several decades in contrast to the other major malignancies such as lung, breast, prostate and colorectal cancers. Endoscopic ultrasound, with its highest level of detection capacity of smaller pancreatic lesions, is the commonly employed and preferred clinical imaging-based PDAC detection method. Various molecular biomarkers ha...
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Urayama S Tags: World J Gastroenterol Source Type: research

Vitamin D: A new player in non-alcoholic fatty liver disease?
Abstract Vitamin D through its active form 1a-25-dihydroxyvtamin D [1,25(OH)2D] is a secosteroid hormone that plays a key role in mineral metabolism. Recent years have witnessed a significant scientific interest on vitamin D and expanded its actions to include immune modulation, cell differentiation and proliferation and inflammation regulation. As our understanding of the many functions of vitamin D has grown, the presence of vitamin D deficiency has become one of the most prevalent micronutrient deficiencies worldwide. Concomitantly, non-alcoholic fatty liver disease (NAFLD) has become the most common form of chr...
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Eliades M, Spyrou E Tags: World J Gastroenterol Source Type: research

Biological therapy in inflammatory bowel diseases: Access in Central and Eastern Europe.
In conclusion, access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors, drug prices or total health expenditure. Changes in reimbursement policy could contribute to better access to biologicals in some countries. PMID: 25684937 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Rencz F, Péntek M, Bortlik M, Zagorowicz E, Hlavaty T, Śliwczyński A, Diculescu MM, Kupcinskas L, Gecse KB, Gulácsi L, Lakatos PL Tags: World J Gastroenterol Source Type: research

Management of patients with hepatitis B in special populations.
Abstract The development of effective nucleos(t)ide analogs (NAs) against hepatitis B virus (HBV) has improved the outcome of patients with chronic hepatitis B (CHB). This review updates issues related to the management of CHB patients included in special populations. Entecavir (ETV) and tenofovir (TDF) represent the currently recommended first-line NAs in patients with HBV decompensated cirrhosis. The combination of HBV immunoglobulin (usually for a finite duration) and NA is considered the standard of care for prophylaxis against HBV recurrence after liver transplantation. TDF is the best choice for hemodialysis ...
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Cholongitas E, Tziomalos K, Pipili C Tags: World J Gastroenterol Source Type: research

Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia.
CONCLUSION: Immunohistochemical NK-1R and pEGFR positivity with VDR negativity can be used to identify areas of sporadic colorectal neoplasia. VDR immunoreactivity can distinguish CAC from sporadic cancer. PMID: 25684939 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Isidro RA, Cruz ML, Isidro AA, Baez A, Arroyo A, González-Marqués WA, González-Keelan C, Torres EA, Appleyard CB Tags: World J Gastroenterol Source Type: research

Beta-7 integrin controls enterocyte migration in the small intestine.
CONCLUSION: The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. PMID: 25684940 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Kaemmerer E, Kuhn P, Schneider U, Clahsen T, Jeon MK, Klaus C, Andruszkow J, Härer M, Ernst S, Schippers A, Wagner N, Gassler N Tags: World J Gastroenterol Source Type: research

Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach.
CONCLUSION: Our study shows that IGL-1 preservation solution enriched with TMZ protects liver grafts from the IRI associated with OLT, through SIRT1 up-regulation. PMID: 25684941 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Pantazi E, Zaouali MA, Bejaoui M, Folch-Puy E, Ben Abdennebi H, Varela AT, Rolo AP, Palmeira CM, Roselló-Catafau J Tags: World J Gastroenterol Source Type: research

Nitrite, a novel method to decrease ischemia/reperfusion injury in the rat liver.
CONCLUSION: Nitrite administered before liver ischemia in the rat liver reduces anaerobic metabolism and cell necrosis, which could be important in the clinical setting. PMID: 25684942 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Björnsson B, Bojmar L, Olsson H, Sundqvist T, Sandström P Tags: World J Gastroenterol Source Type: research

In vitro identification of nonalcoholic fatty liver disease-related protein hnRNPM.
CONCLUSION: The results suggest that glyceraldehyde-modified hnRNPM alters gene expression. This change may cause adverse effects in hepatocytes and may serve as a target for therapeutic intervention. PMID: 25684943 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Takino J, Nagamine K, Takeuchi M, Hori T Tags: World J Gastroenterol Source Type: research

Occult infection related hepatitis B surface antigen variants showing lowered secretion capacity.
CONCLUSION: The presently obtained data indicate that deficiency in the secretion capacity of HBsAg variants may have a pivotal function in the occult infections of HBV genotype C. PMID: 25684944 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Kim H, Lee SA, Won YS, Lee H, Kim BJ Tags: World J Gastroenterol Source Type: research

Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3.
CONCLUSION: The overexpression of B7-H3 induces resistance to apoptosis in colorectal cancer cell lines by upregulating the Jak2-STAT3 signaling pathway, potentially providing new approaches to the treatment of colorectal cancer. PMID: 25684945 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Zhang T, Jiang B, Zou ST, Liu F, Hua D Tags: World J Gastroenterol Source Type: research

Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation.
CONCLUSION: This study indicates that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. CBP may be a potential tumor suppressor and targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma. PMID: 25684946 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Zhou D, Dong P, Li YM, Guo FC, Zhang AP, Song RZ, Zhang YM, Li ZY, Yuan D, Yang C Tags: World J Gastroenterol Source Type: research

New parameter in diagnosis of acute appendicitis: Platelet distribution width.
CONCLUSION: Platelet distribution width analysis can be used for diagnosis of acute appendicitis without requiring additional tests, thus reducing the cost and loss of time. PMID: 25684947 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Dinc B, Oskay A, Dinc SE, Bas B, Tekin S Tags: World J Gastroenterol Source Type: research

Digitally reinforced hematoxylin-eosin polarization technique in diagnosis of rectal amyloidosis.
CONCLUSION: The DRHEP technique improves diagnostic accuracy when used as an adjunct or a prior step to CR staining, especially for cases with limited tissues for further analysis. PMID: 25684948 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Doganavsargil B, Buberal GE, Toz H, Sarsik B, Pehlivanoglu B, Sezak M, Sen S Tags: World J Gastroenterol Source Type: research

Fibroblast growth factor receptor 4 protein expression and clinicopathological features in gastric cancer.
CONCLUSION: Our results suggest that high tumor expression of FGFR4 protein is not an independent risk factor for GC cancer initiation, but is a useful prognostic marker for GC patients when the tumor is relatively small, well differentiated, or in the early stages of invasion. PMID: 25684949 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Chen H, Shen DP, Zhang ZZ, Liu JH, Shen YY, Ni XZ Tags: World J Gastroenterol Source Type: research

Retrospective analysis of extra-gastrointestinal stromal tumors.
CONCLUSION: Because the biologic behaviors of GISTs differ according to the location of the tumor, a more stratified strategy is required for managing EGISTs including incorporation of molecular features. PMID: 25684950 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Yi JH, Park BB, Kang JH, Hwang IG, Shin DB, Sym SJ, Ahn HK, Lee SI, Lim do H, Park KW, Won YW, Lim SH, Park SH Tags: World J Gastroenterol Source Type: research

Tumor regression grades: Potential outcome predictor of locally advanced rectal adenocarcinoma after preoperative radiotherapy.
CONCLUSION: Mandard grade good responders had a favorable prognosis. TRG may be a potential predictor for DFS in LARA after pre-RT. PMID: 25684951 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Peng YF, Yu WD, Pan HD, Wang L, Li M, Yao YF, Zhao J, Gu J Tags: World J Gastroenterol Source Type: research

Prediction of synchronous colorectal cancers by computed tomography in subjects receiving an incomplete colonoscopy: A single-center study.
CONCLUSION: CT has limited sensitivity in detecting SCRCs in patients receiving incomplete colonoscopy. Patients with risk factors and negative CT results should be closely examined and monitored. PMID: 25684952 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Pang EJ, Liu WJ, Peng JY, Chen NW, Deng JH Tags: World J Gastroenterol Source Type: research

Prognostic factors and survival in patients with gastric stump cancer.
CONCLUSION: The appearance of GSC occurs sooner in patients with primary malignant cancer than in patients with a primary benign disease. Therefore, close follow-up is necessary. The overall survival of patients with GSC is poor, and curative resection can improve their prognosis. PMID: 25684953 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Huang H, Wang W, Chen Z, Jin JJ, Long ZW, Cai H, Liu XW, Zhou Y, Wang YN Tags: World J Gastroenterol Source Type: research

Application of air insufflation to prevent clinical pancreatic fistula after pancreaticoduodenectomy.
CONCLUSION: Performing an air insufflation test could significantly reduce the occurrence of clinical PF after PD. Not performing an air insufflation test was an independent risk factor for clinical PF. PMID: 25684954 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Yang H, Lu XF, Xu YF, Liu HD, Guo S, Liu Y, Chen YX Tags: World J Gastroenterol Source Type: research

Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis.
CONCLUSION: Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation. Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. PMID: 25684955 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Kawakami K, Inoue T, Murano M, Narabayashi K, Nouda S, Ishida K, Abe Y, Nogami K, Hida N, Yamagami H, Watanabe K, Umegaki E, Nakamura S, Arakawa T, Higuchi K Tags: World J Gastroenterol Source Type: research

Assessing cultural competency skills in gastroenterology fellowship training.
CONCLUSION: OSCEs can be used to assess deficiencies in culturally-competent care at the fellowship level. OSCEs also afford fellowships the opportunity to inform future training curricula. PMID: 25684956 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Balzora S, Abiri B, Wang XJ, McKeever J, Poles M, Zabar S, Gillespie C, Weinshel E Tags: World J Gastroenterol Source Type: research

Snapshot of an integrated psychosocial gastroenterology service.
CONCLUSION: Patients are receptive to psychological interventions for GI conditions and there is preliminary evidence that treatment can decrease health-care utilization among patients with functional GI conditions. PMID: 25684957 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Kinsinger SW, Ballou S, Keefer L Tags: World J Gastroenterol Source Type: research

Measures of patient radiation exposure during endoscopic retrograde cholangiography: Beyond fluoroscopy time.
CONCLUSION: DAP and DOSERP in addition to FT should be adopted as new ERCP quality measures to estimate patient radiation exposure. PMID: 25684958 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Kachaamy T, Harrison E, Pannala R, Pavlicek W, Crowell MD, Faigel DO Tags: World J Gastroenterol Source Type: research

Significance of low level infliximab in the absence of anti-infliximab antibodies.
CONCLUSION: DN status may result from false negative detection of IFX or ATI by double antigen ELISA, suggesting a transitional state of low-level immunogenicity, rather than non-immunological clearance. PMID: 25684959 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Ungar B, Anafy A, Yanai H, Ron Y, Yavzori M, Picard O, Fudim E, Loebstein R, Kopylov U, Chowers Y, Dotan I, Eliakim R, Ben-Horin S Tags: World J Gastroenterol Source Type: research

Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease: Need for mucosal viral load measurement.
CONCLUSION: Viral colitis appeared to contribute to mucosal lesions in refractory IBD, and its correct diagnosis and management require quantitative real-time polymerase chain reaction assay of mucosal specimens. PMID: 25684960 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Ciccocioppo R, Racca F, Paolucci S, Campanini G, Pozzi L, Betti E, Riboni R, Vanoli A, Baldanti F, Corazza GR Tags: World J Gastroenterol Source Type: research

Acute fatty liver of pregnancy: Over six months follow-up study of twenty-five patients.
CONCLUSION: Acute liver failure and acute renal failure in AFLP patients is reversible. Patients do not require any specific long-term follow-up after recovery from AFLP if their liver function tests have normalized and they remain well. PMID: 25684961 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Xiong HF, Liu JY, Guo LM, Li XW Tags: World J Gastroenterol Source Type: research

Incidence and psychological-behavioral characteristics of refractory functional dyspepsia: A large, multi-center, prospective investigation from China.
CONCLUSION: RFD is not rare in clinical practice and should get attention by patients and doctors because of its long duration, severe symptoms, and associations with abnormal psychology and poor quality of life. PMID: 25684962 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Jiang SM, Jia L, Lei XG, Xu M, Wang SB, Liu J, Song M, Li WD Tags: World J Gastroenterol Source Type: research

Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation.
CONCLUSION: 4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acid- PEG and is associated with a higher rate of excellent preparations; Clinicaltrial.gov identifier: NCT01788709. PMID: 25684963 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Sharara AI, Harb AH, Sarkis FS, Chalhoub JM, Badreddine R, Mourad FH, Othman M, Masri O Tags: World J Gastroenterol Source Type: research

Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR: A systematic literature review.
CONCLUSION: As reported in this review, octreotide-LAR at doses > 30 mg/mo is being prescribed for symptom and tumor control in NET patients. Furthermore, expert clinical opinion provided support for escalation of somatostatin analogs for refractory hormonal symptoms. PMID: 25684964 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Broder MS, Beenhouwer D, Strosberg JR, Neary MP, Cherepanov D Tags: World J Gastroenterol Source Type: research

Distinctive inflammatory bowel disease phenotype in primary sclerosing cholangitis.
CONCLUSION: IBD in primary sclerosing cholangitis represents a distinct phenotype that differs from UC and Crohn's disease and therefore requires specialized management. PMID: 25684965 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: de Vries AB, Janse M, Blokzijl H, Weersma RK Tags: World J Gastroenterol Source Type: research

Chronic hepatitis C genotype 1 treatment roadmap for resource constrained settings.
CONCLUSION: Using a roadmap based on HCVRNA(-) at TW4 or TW8 (the "80-80" rule), high SVR can be achieved, and guide the best choices for treatment, and also reduces drug exposure in poor responders. PMID: 25684966 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Lim SG Tags: World J Gastroenterol Source Type: research

Successful treatment of conversion chemotherapy for initially unresectable synchronous colorectal liver metastasis.
Abstract A 72-year-old woman with a sigmoid colon cancer and a synchronous colorectal liver metastasis (CRLM), which involved the right hepatic vein (RHV) and the inferior vena cava (IVC), was referred to our hospital. The metastatic lesion was diagnosed as initially unresectable because of its invasion into the confluence of the RHV and IVC. After she had undergone laparoscopic sigmoidectomy for the original tumor, she consequently had 3 courses of modified 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus cetuximab. Computed tomography revealed a partial response, and the confluence of the RHV and IVC g...
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Baba K, Oshita A, Kohyama M, Inoue S, Kuroo Y, Yamaguchi T, Nakamura H, Sugiyama Y, Tazaki T, Sasaki M, Imamura Y, Daimaru Y, Ohdan H, Nakamitsu A Tags: World J Gastroenterol Source Type: research

Rapidly aggravated skeletal muscle metastases from an intrahepatic cholangiocarcinoma.
We present a rare case of intrahepatic cholangiocarcinoma (ICC) with multiple skeletal muscle metastases. The patient was a 55-year-old Asian woman presenting with abdominal pain; abdominal and pelvic computed tomography and magnetic resonance cholangiopancreatography revealed an unresectable ICC with hepatic metastasis and metastastatic lymphadenopathy in the porto-caval area. After 3 mo of treatment with palliative radiotherapy and chemotherapy, magnetic resonance imaging of the thoracolumbar spine detected right psoas muscle and paraspinous muscle metastases. We performed an ultrasound-guided percutaneous fine-needle bi...
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Lee J, Lee SW, Han SY, Baek YH, Kim SY, Rhyou HI Tags: World J Gastroenterol Source Type: research

Retreatment with peginterferon and ribavirin in chronic hepatitis C.
Abstract The development of boceprevir and telaprevir was a major step forward in the treatment of chronic hepatitis C. In addition, the treatment of these infections has been recently revolutionized by the approval of sofosbuvir and simeprevir. However, there are several challenges associated with the application of novel drugs, such as new and more frequent adverse events, new drug interactions, and excessively high treatment costs. An additional concern is viral resistance. These considerations highlight the fact that direct-acting antiviral agents are not a panacea and may not be the best option for all patient...
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Jo YM, Lee SW, Han SY, Baek YH, Kim SY, Kim WJ, Ahn JH, Lee JY Tags: World J Gastroenterol Source Type: research

Successful treatment of complex cholangiolithiasis following orthotopic liver transplantation with interventional radiology.
Abstract Bile duct stones are a serious and the third most common complication of the biliary system that can occur following liver transplantation. The incidence rate of bile duct stones after liver transplantation is 1.8%-18%. The management of biliary stones is usually performed with endoscopic techniques; however, the technique may prove to be challenging in the treatment of the intrahepatic bile duct stones. We herein report a case of a 40-year-old man with rare, complex bile duct stones that were successfully eliminated with percutaneous interventional techniques. The complex bile duct stones were defined as ...
Source: World Journal of Gastroenterology : WJG - February 14, 2015 Category: Gastroenterology Authors: Zhou CG, Wei BJ, Gao K, Dai DK, Zhai RY Tags: World J Gastroenterol Source Type: research

Does endoscopic ultrasound-guided biliary drainage really have clinical impact?
Abstract The well established, gold standard method for treatment of obstructive jaundice involves biliary drainage under endoscopic retrograde cholangiopancreatography (ERCP) performed by pancreatobiliary endoscopists. Recently, interventions using endoscopic ultrasound (EUS) have been developed not only for obtaining cytological and histological diagnosis, but also for biliary drainage as alternative method. EUS-guided biliary drainage (EUS-BD) was first reported by Giovannini et al. EUS-BD broadly includes EUS-guided rendezvous technique, EUS-guided choledochoduodenostomy, and EUS-guided hepaticogastrostomy. Mor...
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Ogura T, Higuchi K Tags: World J Gastroenterol Source Type: research

Management of obstructed defecation.
Abstract The management of obstructed defecation syndrome (ODS) is mainly conservative and mainly consists of fiber diet, bulking laxatives, rectal irrigation or hydrocolontherapy, biofeedback, transanal electrostimulation, yoga and psychotherapy. According to our experience, nearly 20% of the patients need surgical treatment. If we consider ODS an "iceberg syndrome", with "emerging rocks", rectocele and rectal internal mucosal prolapse, that may benefit from surgery, at least two out of ten patients also has "underwater rocks" or occult disorders, such as anismus, rectal hyposensation and anxiety/depression, which...
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Podzemny V, Pescatori LC, Pescatori M Tags: World J Gastroenterol Source Type: research

Markers of acute rejection and graft acceptance in liver transplantation.
Abstract The evaluation of the immunosuppression state in liver transplanted patients is crucial for a correct post-transplant management and a major step towards the personalisation of the immunosuppressive therapy. However, current immunological monitoring after liver transplantation relies mainly on clinical judgment and on immunosuppressive drug levels, without a proper assessment of the real suppression of the immunological system. Various markers have been studied in an attempt to identify a specific indicator of graft rejection and graft acceptance after liver transplantation. Considering acute rejection, th...
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Germani G, Rodriguez-Castro K, Russo FP, Senzolo M, Zanetto A, Ferrarese A, Burra P Tags: World J Gastroenterol Source Type: research

Preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: What can be done?
Abstract Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is the most common complication of endoscopic retrograde cholangiopancreatography. The incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis varies substantially and is reported around 1%-10%, although there are some reports with an incidence of around 30%. Usually, PEP is a mild or moderate pancreatitis, but in some instances it can be severe and fatal. Generally, it is defined as the onset of new pancreatic-type abdominal pain severe enough to require hospital admission or prolonged hospital stay with le...
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Hauser G, Milosevic M, Stimac D, Zerem E, Jovanović P, Blazevic I Tags: World J Gastroenterol Source Type: research

Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: A review.
Abstract Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn's disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls. In the present article, we review the mechanisms in which hy...
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Keshteli AH, Baracos VE, Madsen KL Tags: World J Gastroenterol Source Type: research

Benign esophageal lesions: Endoscopic and pathologic features.
Abstract Benign esophageal lesions have a wide spectrum of clinical and pathologic features. Understanding the endoscopic and pathologic features of esophageal lesions is essential for their detection, differential diagnosis, and management. The purpose of this review is to provide updated features that may help physicians to appropriately manage these esophageal lesions. The endoscopic features of 2997 patients are reviewed. In epithelial lesions, the frequency of occurrence was in the following order: glycogenic acanthosis, heterotopic gastric mucosa, squamous papilloma, hyperplastic polyp, ectopic sebaceous glan...
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ Tags: World J Gastroenterol Source Type: research

Novel insights into the mechanisms whereby isoflavones protect against fatty liver disease.
Abstract Fatty liver disease (FLD) is a growing public health problem worldwide. There is an urgent requirement for alternative and natural medicine to treat this disease. As phytochemicals, isoflavones have attracted considerable attention for the prevention of FLD. Numerous studies have revealed that isoflavones protect against FLD through various pathways which modulate fatty acid β-oxidation, lipid synthesis, and oxidative stress. Recently, the aldose reductase (AR)/polyol pathway has been reported to be involved in the development of FLD by modulating hepatic fructose production, peroxisome proliferator-activ...
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Qiu LX, Chen T Tags: World J Gastroenterol Source Type: research

Metabolic shift in liver: Correlation between perfusion temperature and hypoxia inducible factor-1α.
CONCLUSION: Livers perfused at 10 and 20 °C show no sign of liver injury or anaerobiosis, in contrast to livers perfused at 30 and 37 °C. PMID: 25632183 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Ferrigno A, Di Pasqua LG, Bianchi A, Richelmi P, Vairetti M Tags: World J Gastroenterol Source Type: research

Effects of traditional Chinese herbal medicine San-Huang-Xie-Xin-Tang on gastrointestinal motility in mice.
CONCLUSION: These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GMD. PMID: 25632184 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Hwang MW, Ahn TS, Hong NR, Jeong HS, Jung MH, Ha KT, Kim BJ Tags: World J Gastroenterol Source Type: research

Weichang'an and 5-fluorouracil suppresses colorectal cancer in a mouse model.
CONCLUSION: Combination of WCA with 5-FU significantly inhibited colon tumor growth and hepatic metastases. Decreased expression of β-catenin and MMP-7 may be important. PMID: 25632185 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Tao L, Yang JK, Gu Y, Zhou X, Zhao AG, Zheng J, Zhu YJ Tags: World J Gastroenterol Source Type: research

Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival.
CONCLUSION: The loss of stromal CAV-1 expression in CRC was associated with poor prognosis and could be a prognostic factor for CRC patients. PMID: 25632186 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Zhao Z, Han FH, Yang SB, Hua LX, Wu JH, Zhan WH Tags: World J Gastroenterol Source Type: research

β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma.
CONCLUSION: β-escin was a potent reverser of P-gp-dependent multidrug resistance, with said effect likely being achieved via inhibition of the GSK3β/β-catenin pathway and thus suggesting a promising strategy of developing combination drugs for CCA. PMID: 25632187 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2015 Category: Gastroenterology Authors: Huang GL, Shen DY, Cai CF, Zhang QY, Ren HY, Chen QX Tags: World J Gastroenterol Source Type: research