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Field cancerisation in colorectal cancer: A new frontier or pastures past?
Abstract Despite considerable advances in our understanding of cancer biology, early diagnosis of colorectal cancer remains elusive. Based on the adenoma-carcinoma sequence, cancer develops through the progressive accumulation of mutations in key genes that regulate cell growth. However, recent mathematical modelling suggests that some of these genetic events occur prior to the development of any discernible histological abnormality. Cells acquire pro-tumourigenic mutations that are not able to produce morphological change but predispose to cancer formation. These cells can grow to form large patches of mucosa from...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Patel A, Tripathi G, Gopalakrishnan K, Williams N, Arasaradnam RP Tags: World J Gastroenterol Source Type: research

Helicobacter pylori eradication in gastric diffuse large B cell lymphoma.
Abstract Diffuse large B cell lymphoma (DLBCL) of the stomach is a heterogenous disease. There are tumors without histological evidence of mucosa-associated lymphoid tissue (MALT) lymphoma, which are classified as pure or de novo DLBCL and those with evidence of MALT, which are classified as DLBCL (MALT). The association between Helicobacter pylori (H. pylori) and gastric MALT lymphoma and remission with H. pylori eradication was shown in the 1990s. In recent years, scientists from Taiwan and others have shown that high-grade gastric lymphomas may be dependent on H. pylori and eradication of this microorganism is e...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Paydas S Tags: World J Gastroenterol Source Type: research

Current pharmacological therapies for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Abstract Nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) is considered to be a hepatic manifestation of metabolic syndrome, and its incidence is rapidly increasing worldwide. It is currently the most common chronic liver disease. NASH can progress to liver cirrhosis and hepatocellular carcinoma, and may result in liver-related death. Currently, the principal treatment for NAFLD/NASH is lifestyle modification by diet and exercise. However, pharmacological therapy is indispensable because obese patients with NAFLD often have difficulty maintaining improved lifestyles. The pathogenesis of ...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Takahashi Y, Sugimoto K, Inui H, Fukusato T Tags: World J Gastroenterol Source Type: research

Hepatitis C virus and antiviral innate immunity: Who wins at tug-of-war?
Abstract Hepatitis C virus (HCV) is a major human pathogen of chronic hepatitis and related liver diseases. Innate immunity is the first line of defense against invading foreign pathogens, and its activation is dependent on the recognition of these pathogens by several key sensors. The interferon (IFN) system plays an essential role in the restriction of HCV infection via the induction of hundreds of IFN-stimulated genes (ISGs) that inhibit viral replication and spread. However, numerous factors that trigger immune dysregulation, including viral factors and host genetic factors, can help HCV to escape host immune r...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Yang DR, Zhu HZ Tags: World J Gastroenterol Source Type: research

Gastrointestinal Behçet's disease: A review.
Abstract Behçet's disease (BD) is an idiopathic, chronic, relapsing, multi-systemic vasculitis characterized by recurrent oral and genital aphthous ulcers, ocular disease and skin lesions. Prevalence of BD is highest in countries along the ancient silk road from the Mediterranean basin to East Asia. By comparison, the prevalence in North American and Northern European countries is low. Gastrointestinal manifestations of Behçet's disease are of particular importance as they are associated with significant morbidity and mortality. Although ileocecal involvement is most commonly described, BD may involve any segment...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Skef W, Hamilton MJ, Arayssi T Tags: World J Gastroenterol Source Type: research

New gene therapy strategies for hepatic fibrosis.
Abstract The liver is the largest internal organ of the body, which may suffer acute or chronic injury induced by many factors, leading to cirrhosis and hepatocarcinoma. Cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of the normal hepatic structure, regenerative nodules and fibrotic tissue. Cirrhosis is associated with a high co-morbidity and mortality without effective treatment, and much research has been aimed at developing new therapeutic strategies to guarantee recovery. Liver-based gene therapy has been used to downregulat...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Salazar-Montes AM, Hernández-Ortega LD, Lucano-Landeros MS, Armendariz-Borunda J Tags: World J Gastroenterol Source Type: research

Current management of hepatocellular carcinoma: An Eastern perspective.
Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death, especially in Eastern areas. With advancements in diagnosis and treatment modalities for HCC, the survival and prognosis of HCC patients are improving. However, treatment patterns are not uniform between areas despite efforts to promote a common protocol. Although many hepatologists in Asian countries may adopt the principles of the Barcelona Clinic Liver Cancer staging system, they are also independently making an effort to expand the indications of each treatment and to combine therapies for better outcomes. Several expanded cri...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Yim HJ, Suh SJ, Um SH Tags: World J Gastroenterol Source Type: research

Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Surgery, percutaneous ablation and liver transplantation are the only curative treatment modalities for HCC. However, the majority of patients have unresectable disease at diagnosis. Therefore, effective treatment options for patients with advanced HCC are required. In advanced HCC, according to current international guidelines, sorafenib, a molecular targeted agent, is the standard treatment. However, alternative treatment modalities are required because of the low response rates and unsuitability of molecular agents in real pract...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Song MJ Tags: World J Gastroenterol Source Type: research

Adjuvant therapy for gastric cancer: What have we learned since INT0116?
The objective of the present review is to report the major advances obtained in the last decades in the adjuvant treatment of gastric cancer as well as the perspectives of treatment based on recent knowledge of the molecular biology of the disease. PMID: 25852269 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Jácome AA, Sankarankutty AK, Dos Santos JS Tags: World J Gastroenterol Source Type: research

Antiviral therapies for hepatitis B virus-related hepatocellular carcinoma.
Abstract Chronic hepatitis B virus (HBV) infection is a critical risk factor for the carcinogenesis and progression of hepatocellular carcinoma (HCC). It promotes HCC development by inducing liver fibrogenesis, genetic and epigenetic alterations, and the expression of active viral-coded proteins. Effective antiviral treatments inhibit the replication of HBV, reduce serum viral load and accelerate hepatitis B e antigen serum conversion. Timely initiation of antiviral treatment is not only essential for preventing the incidence of HCC in chronic hepatitis B patients, but also important for reducing HBV reactivation, ...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Zhang YQ, Guo JS Tags: World J Gastroenterol Source Type: research

Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 receptor mRNA expression in chronic hepatitis C.
CONCLUSION: Differences in quantitative expression of IGF-1 mRNA isoforms in HCV-infected livers, as compared to the control, suggest that HCV may induce alteration of IGF-1 splicing profile. PMID: 25852271 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Kasprzak A, Adamek A, Przybyszewska W, Pyda P, Szmeja J, Seraszek-Jaros A, Lanzafame A, Surdacka A, Mozer-Lisewska I, Koczorowska M Tags: World J Gastroenterol Source Type: research

Fucosylation is a common glycosylation type in pancreatic cancer stem cell-like phenotypes.
CONCLUSION: Fucosylation might be a biomarker of CSC-like cells in pancreatic cancer. PMID: 25852272 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Terao N, Takamatsu S, Minehira T, Sobajima T, Nakayama K, Kamada Y, Miyoshi E Tags: World J Gastroenterol Source Type: research

Esophageal variceal pressure influence on the effect of ligation.
CONCLUSION: Higher variceal pressures impair the ligation completion rate. Therefore, measuring variceal pressure may help predict the effect of endoscopic ligation and guide treatment choice. PMID: 25852273 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Li ZQ, LingHu EQ, Hu M, Li WM, Huang QY, Zhao YW Tags: World J Gastroenterol Source Type: research

Caffeic acid phenethyl ester inhibits liver fibrosis in rats.
CONCLUSION: The protective effects of CAPE against liver fibrosis may be due to its ability to suppress the activation of HSCs by inhibiting oxidative stress. PMID: 25852274 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Li M, Wang XF, Shi JJ, Li YP, Yang N, Zhai S, Dang SS Tags: World J Gastroenterol Source Type: research

Interferon-λ3 polymorphisms in pegylated-interferon-α plus ribavirin therapy for genotype-2 chronic hepatitis C.
CONCLUSION: In response-guided Peg-IFNα/RBV combination therapy for chronically HCV G2-infected patients, the impact of the IFNL3 genotype on SVR was limited to non-RVR patients. PMID: 25852275 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Ishiguro H, Abe H, Seki N, Sugita T, Aida Y, Itagaki M, Sutoh S, Shimada N, Furihata T, Tsubota A, Aizawa Y Tags: World J Gastroenterol Source Type: research

Hepatitis C virus recurrence after liver transplantation: A 10-year evaluation.
CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence. PMID: 25852276 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Gitto S, Belli LS, Vukotic R, Lorenzini S, Airoldi A, Cicero AF, Vangeli M, Brodosi L, Panno AM, Di Donato R, Cescon M, Grazi GL, De Carlis L, Pinna AD, Bernardi M, Andreone P Tags: World J Gastroenterol Source Type: research

Clinical and computed tomography findings of appendiceal diverticulitis vs acute appendicitis.
CONCLUSION: Among patients who had undergone appendectomy, 9.7% had appendiceal diverticulitis. Patients with appendiceal diverticulitis had different clinical features and CT findings from patients with acute appendicitis. PMID: 25852277 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Ito D, Miki K, Seiichiro S, Hata S, Kobayashi K, Teruya M, Kaminishi M Tags: World J Gastroenterol Source Type: research

Diagnostic value of PIVKA-II and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma.
CONCLUSION: Serum PIVKA-II might be a better tumor marker than AFP, and its combination with AFP may enhance the early detection of HCC in patients with CHB. PMID: 25852278 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Seo SI, Kim HS, Kim WJ, Shin WG, Kim DJ, Kim KH, Jang MK, Lee JH, Kim JS, Kim HY, Kim DJ, Lee MS, Park CK Tags: World J Gastroenterol Source Type: research

Eradication rate and histological changes after Helicobacter pylori eradication treatment in gastric cancer patients following subtotal gastrectomy.
CONCLUSION: Patients with H. pylori following subtotal gastrectomy had a similar eradication rate to patients with an intact stomach. H. pylori eradication is recommended after subtotal gastrectomy. PMID: 25852279 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Hwang JJ, Lee DH, Kang KK, Lee AR, Yoon H, Shin CM, Park YS, Kim N Tags: World J Gastroenterol Source Type: research

Is endoscopic submucosal dissection safe for papillary adenocarcinoma of the stomach?
CONCLUSION: The use of ESD should be carefully considered for papillary adenocarcinoma-type EGC with suspected ESD indication after pre-treatment work-up because of the higher frequency of LN metastasis and additional surgeries. PMID: 25852280 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Lee HJ, Kim GH, Park do Y, Lee BE, Jeon HK, Jhi JH, Song GA Tags: World J Gastroenterol Source Type: research

Differentiation of acute and chronic hepatitis B in IgM anti-HBc positive patients.
CONCLUSION: The combination of the S/CO ratio of IgM anti-HBc and HBV DNA levels was a useful tool for differentiating AHB from CHB-AE in patients with positive IgM anti-HBc. PMID: 25852281 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Park JW, Kwak KM, Kim SE, Jang MK, Kim DJ, Lee MS, Kim HS, Park CK Tags: World J Gastroenterol Source Type: research

Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma.
CONCLUSION: IRAK3 and GLOXD1 were frequently methylated in HCC tissues compared to normal controls and nontumor tissues. IRAK3 methylation was associated with tumor stage and poor prognosis of patients. These data suggest that IRAK3 methylation is a novel prognostic marker in HCC. PMID: 25852282 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Kuo CC, Shih YL, Su HY, Yan MD, Hsieh CB, Liu CY, Huang WT, Yu MH, Lin YW Tags: World J Gastroenterol Source Type: research

Oxaliplatin and 5-fluorouracil hepatic infusion with lipiodolized chemoembolization in large hepatocellular carcinoma.
CONCLUSION: Hepatic infusion of oxaliplatin and 5-fluorouracil followed by lipiodolized-chemoembolization is a safe and promising treatment for patients with HCCs larger than 10 cm in diameter. PMID: 25852283 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Li JH, Xie XY, Zhang L, Le F, Ge NL, Li LX, Gan YH, Chen Y, Zhang JB, Xue TC, Chen RX, Xia JL, Zhang BH, Ye SL, Wang YH, Ren ZG Tags: World J Gastroenterol Source Type: research

Endoscopic transpancreatic septotomy as a precutting technique for difficult bile duct cannulation.
CONCLUSION: Pancreatic guidewire or pancreatic duct plastic stent assistance improves the success rate of selective bile duct cannulation in ERCP. TS and NKS markedly improve the success rate of selective bile duct cannulation in ERCP. TS precut is safer as compared with NKS. PMID: 25852284 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Miao L, Li QP, Zhu MH, Ge XX, Yu H, Wang F, Ji GZ Tags: World J Gastroenterol Source Type: research

Decreased STAT4 indicates poor prognosis and enhanced cell proliferation in hepatocellular carcinoma.
CONCLUSION: Our data indicate that STAT4 may inhibit HCC development by modulating HCC cell proliferation. PMID: 25852285 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Wang G, Chen JH, Qiang Y, Wang DZ, Chen Z Tags: World J Gastroenterol Source Type: research

Importance of reporting segmental bowel preparation scores during colonoscopy in clinical practice.
CONCLUSION: Segmental AADRs correlate with segmental BBPS. It is thus valuable to report segmental BBPS in colonoscopy reports in clinical practice. PMID: 25852286 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Jain D, Momeni M, Krishnaiah M, Anand S, Singhal S Tags: World J Gastroenterol Source Type: research

Rectal tone and compliance affected in patients with fecal incontinence after fistulotomy.
CONCLUSION: In patients with FIAF, normal motor anal sphincter function and rectal sensitivity are preserved, but rectal tone and compliance are impaired. The results suggest that FIAF is not due to alterations in rectal sensitivity and that the rectum is more involved than the anal sphincters in the genesis of FIAF. PMID: 25852287 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Awad RA, Camacho S, Flores F, Altamirano E, García MA Tags: World J Gastroenterol Source Type: research

Interferon-λ-related genes and therapeutic response in Chinese hepatitis C patients.
CONCLUSION: IL28B rs12980275 AA genotype is a strong predictor of positive response to IFN therapy in Chinese Han patients with hepatitis C. PMID: 25852288 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Zhang YY, Chen HB, Xu Y, Huang P, Wang J, Zhang Y, Yu RB, Su J Tags: World J Gastroenterol Source Type: research

Endoscopic ultrasound elastography strain histograms in the evaluation of patients with pancreatic masses.
CONCLUSION: SH showed high sensitivity in pancreatic malignant tumor detection but disappointingly low specificity. Slight improvements in specificity and accuracy were achieved using the SH ratio. PMID: 25852289 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Opačić D, Rustemović N, Kalauz M, Markoš P, Ostojić Z, Majerović M, Ledinsky I, Višnjić A, Krznarić J, Opačić M Tags: World J Gastroenterol Source Type: research

PERFACT procedure: A new concept to treat highly complex anal fistula.
CONCLUSION: The PERFACT procedure is a new effective method for complex fistula-in-ano, effective even in fistula associated with abscess, supralevator fistula-in-ano and where the internal opening is non-localizable. PMID: 25852290 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Garg P, Garg M Tags: World J Gastroenterol Source Type: research

Lower gastrointestinal bleeding: Role of 64-row computed tomographic angiography in diagnosis and therapeutic planning.
CONCLUSION: 64-row CTA is safe and effective in making decisions regarding treatment, without performing digital subtraction angiography or surgery, in the majority of patients with lower GI bleeding. PMID: 25852291 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Ren JZ, Zhang MF, Rong AM, Fang XJ, Zhang K, Huang GH, Chen PF, Wang ZY, Duan XH, Han XW, Liu YJ Tags: World J Gastroenterol Source Type: research

Osteoporosis and bone fractures in alcoholic liver disease: A meta-analysis.
CONCLUSION: Current publications indicate significant associations between bone fractures and ALD, independent of BMD or the presence of osteoporosis. PMID: 25852292 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Bang CS, Shin IS, Lee SW, Kim JB, Baik GH, Suk KT, Yoon JH, Kim YS, Kim DJ Tags: World J Gastroenterol Source Type: research

Resolution of Crohn's disease and complex regional pain syndrome following treatment of paratuberculosis.
Abstract A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been tr...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Kuenstner JT, Chamberlin W, Naser SA, Collins MT, Dow CT, Aitken JM, Weg S, Telega G, John K, Haas D, Eckstein TM, Kali M, Welch C, Petrie T Tags: World J Gastroenterol Source Type: research

Urea cycle disorders: A case report of a successful treatment with liver transplant and a literature review.
Abstract The urea cycle is the final pathway for nitrogen metabolism. Urea cycle disorders (UCDs) include a variety of genetic defects, which lead to inefficient urea synthesis. Elevated blood ammonium level is usually dominant in the clinical pattern and the primary manifestations affect the central nervous system. Herein, we report the case of a 17-year-old girl who was diagnosed with UCD at the age of 3. Despite a controlled diet, she was hospitalized several times for acute attacks with recurrent life risk. She came to our attention for a hyperammonemic episode. We proposed an orthotopic liver transplant (OLT) ...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Foschi FG, Morelli MC, Savini S, Dall'Aglio AC, Lanzi A, Cescon M, Ercolani G, Cucchetti A, Pinna AD, Stefanini GF Tags: World J Gastroenterol Source Type: research

Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity.
We describe the case of a 32-year-old man with ulcerative colitis who was admitted with a two-month history of persistent fever following mesalazine treatment initiated 14 mo earlier. At the time of admission, mesalazine dose was increased from 1.5 to 3.0 g/d, and antibiotic therapy was started with no improvement. Three weeks after admission, the patient developed dyspnea, non-productive cough, and chest pain. Severe eosinophilia was detected in laboratory tests, and a computed tomography scan revealed interstitial infiltrates in both lungs, as well as a large pericardial effusion. The bronchoalveolar lavage reported a CD...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Ferrusquía J, Pérez-Martínez I, Gómez de la Torre R, Fernández-Almira ML, de Francisco R, Rodrigo L, Riestra S Tags: World J Gastroenterol Source Type: research

Treatment of Crohn's disease and familial Mediterranean fever by leukopheresis: Single shot for two targets.
Abstract Coexistence of Crohn's disease (CD) and familial Mediterranean fever (FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colch...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Yuksel M, Saygili F, Coskun O, Suna N, Kaplan M, Kuzu UB, Kilic ZM, Ozin YO, Kayacetin E Tags: World J Gastroenterol Source Type: research

Adenocarcinoma arising from heterotopic pancreas at the third portion of the duodenum.
Abstract A 62-year-old Japanese man presented to our hospital with a history of weight loss of 6 kg in 4 mo. Imaging examinations revealed a tumor located on the third portion of the duodenum with stenosis. We suspected duodenal carcinoma and performed pancreas-preserving segmental duodenectomy. Adenocarcinoma arising from a heterotopic pancreas at the third portion of the duodenum was finally diagnosed by immunohistochemical staining. Malignant transformation in the duodenum arising from a heterotopic pancreas is extremely rare; to our knowledge, only 13 cases have been reported worldwide, including the present ca...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Fukino N, Oida T, Mimatsu K, Kuboi Y, Kida K Tags: World J Gastroenterol Source Type: research

Lymphoepithelioma-like cholangiocarcinoma: A mimic of hepatocellular carcinoma on imaging features.
Abstract Primary lymphoepithelioma-like carcinoma in the liver is extremely rare. A few cases of lymphoepithelioma-like cholangiocarcinoma have been reported, but few radiologic features were described. We reviewed 23 cases of lymphoepithelioma-like cholangiocarcinoma reported between 1996 and 2014 and describe a rare case of a 35-year-old woman in our hospital who was diagnosed with lymphoepithelioma-like cholangiocarcinoma of the liver and was a hepatitis B carrier. The tumor (1.6 cm) in our patient appeared to be hypoechoic in sonographic images and hypodense in computed tomography (CT) images. In addition, it w...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Liao TC, Liu CA, Chiu NC, Yeh YC, Chiou YY Tags: World J Gastroenterol Source Type: research

Segmental small bowel necrosis associated with antiphospholipid syndrome: A case report.
We report the case of a 50-year-old, previously healthy man who presented with fever and new-onset, dull abdominal pain. A contrast-enhanced computed tomography scan showed segmental small bowel obstruction, for which an emergency laparotomy was performed. Histopathologic examination of resected tissues revealed multiple intestinal and mesenteric thromboses of small vessels. Laboratory tests for serum antiphospholipid (anticardiolipin IgM) and anti-β2-glycoprotein I antibodies were positive. Despite proactive implementation of anticoagulation, steroid, and antibiotic therapies, the patient's condition rapidly deteriorated...
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Wang QY, Ye XH, Ding J, Wu XK Tags: World J Gastroenterol Source Type: research

Lower folate levels in gastric cancer: Is it a cause or a result?
Abstract Folate deficiency and its association with cancer have been studied in the literature, but its clinical impact is still unknown. Folate deficiency and its result on gastric cancer is a mysterious part of oncology, with ongoing studies hopefully clarifying its impact on gastric cancer management. Lee et al studied folate deficiency and its impact on staging and clinical results. Here we try to contribute to the field by expressing our own thoughts about the paper. PMID: 25852300 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Alkan A, Mızrak D, Utkan G Tags: World J Gastroenterol Source Type: research

Management of hepatocellular carcinoma with portal vein thrombosis.
Abstract Management of hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) is complex and requires an understanding of multiple therapeutic options. PVT is present in 10%-40% of HCC at the time of diagnosis, and is an adverse prognostic factor. Management options are limited, as transplantation is generally contraindicated, and surgical resection is only rarely performed in select centers. Systemic medical therapy with sorafenib has been shown to modestly prolong survival. Transarterial chemoembolization has been performed in select cases but has shown a high incidence of complications. Emerging data o...
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Quirk M, Kim YH, Saab S, Lee EW Tags: World J Gastroenterol Source Type: research

Lessons from rare tumors: Hepatic lymphoepithelioma-like carcinomas.
Abstract In this review we focus on lymphoepithelioma-like hepatocellular carcinomas (LEL-HCC) and lymphoepithelioma-like cholangiocarcinomas (LEL-ICC). Despite their rarity, these tumors are of general interest because of their epidemiological and clinical features, and because they represent a distinct model of interaction between the immune system and neoplastic cells. Approximately half of LEL-HCC arise in the context of chronic hepatitis C virus (HCV) infection and have been described both in Eastern and Western patients. By contrast, LEL-ICC is associated in almost all cases with Epstein-Barr virus (EBV) infe...
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Solinas A, Calvisi DF Tags: World J Gastroenterol Source Type: research

Hepatitis C virus-specific cytotoxic T cell response restoration after treatment-induced hepatitis C virus control.
Abstract Hepatitis C virus (HCV)-specific cytotoxic T cell (CTL) response plays a major role in viral control during spontaneous infection resolution. These cells develop an exhausted and pro-apoptotic status during chronic onset, being unable to get rid of HCV. The role of this response in contributing to sustained viral response (SVR) after anti-HCV is controversial. Recent studies show that after successful interferon-based anti-HCV treatment, HCV traces are still detectable and this correlates with a peak of HCV-specific CTL response activation, probably responsible for maintaining SVR by subsequent complete HC...
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Larrubia JR, Moreno-Cubero E, Miquel J, Sanz-de-Villalobos E Tags: World J Gastroenterol Source Type: research

Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: An update.
Abstract Long-chain acyl-CoA synthetase (ACSL) family members include five different ACSL isoforms, each encoded by a separate gene and have multiple spliced variants. ACSLs on endoplasmic reticulum and mitochondrial outer membrance catalyze fatty acids with chain lengths from 12 to 20 carbon atoms to form acyl-CoAs, which are lipid metabolic intermediates and involved in fatty acid metabolism, membrane modifications and various physiological processes. Gain- or loss-of-function studies have shown that the expression of individual ACSL isoforms can alter the distribution and amount of intracellular fatty acids. Cha...
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Yan S, Yang XF, Liu HL, Fu N, Ouyang Y, Qing K Tags: World J Gastroenterol Source Type: research

Genome-based nutrition: An intervention strategy for the prevention and treatment of obesity and nonalcoholic steatohepatitis.
Abstract Obesity and nonalcoholic steatohepatitis are increasing in westernized countries, regardless of their geographic location. In Latin America, most countries, including Mexico, have a heterogeneous admixture genome with Amerindian, European and African ancestries. However, certain high allelic frequencies of several nutrient-related polymorphisms may have been achieved by past gene-nutrient interactions. Such interactions may have promoted the positive selection of variants adapted to regional food sources. At present, the unbalanced diet composition of the Mexicans has led the country to a 70% prevalence ra...
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Roman S, Ojeda-Granados C, Ramos-Lopez O, Panduro A Tags: World J Gastroenterol Source Type: research

Degradation of intestinal mRNA: A matter of treatment.
CONCLUSION: Degradation of intestinal mRNA depends on preparation and storage conditions of the tissue. Cooling, rinsing and separating of intestinal tissue reduce the degradation of mRNA. PMID: 25834314 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Heumüller-Klug S, Sticht C, Kaiser K, Wink E, Hagl C, Wessel L, Schäfer KH Tags: World J Gastroenterol Source Type: research

Effect of entacapone on colon motility and ion transport in a rat model of Parkinson's disease.
CONCLUSION: COMT expression exists in rat colons. The β2 adrenoceptor is involved in the entacapone-induced inhibition of colon motility. Entacapone induces cAMP-dependent Cl(-) secretion in the PD rat. PMID: 25834315 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Li LS, Liu CZ, Xu JD, Zheng LF, Feng XY, Zhang Y, Zhu JX Tags: World J Gastroenterol Source Type: research

Primary analysis and screening of microRNAs in gastric cancer side population cells.
CONCLUSION: There are key miRNAs expressed within the SP cells of the gastric cancer cell line MKN-45, and include hsa-miR-3175, hsa-miR-203, hsa-miR-130a, hsa-miR-324-5p, hsa-miR-34a, and hsa-miR-25-star. PMID: 25834316 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Zhang HH, Gu GL, Zhang XY, Li FZ, Ding L, Fan Q, Wu R, Shi W, Wang XY, Chen L, Wei XM, Yuan XY Tags: World J Gastroenterol Source Type: research

High persistence rate of hepatitis B virus in a hydrodynamic injection-based transfection model in C3H/HeN mice.
CONCLUSION: We have developed a novel HI-based HBV transfection model using C3H/HeN mice, which had a higher HBV persistence rate than the classic C57BL/6 mouse model. PMID: 25834317 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Peng XH, Ren XN, Chen LX, Shi BS, Xu CH, Fang Z, Liu X, Chen JL, Zhang XN, Hu YW, Zhou XH Tags: World J Gastroenterol Source Type: research

Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury.
CONCLUSION: Qingyi decoction ameliorates acute pancreatitis-induced intestinal barrier injury by inhibiting the overexpression of intestinal sPLA2. This mechanism may be similar to that of verapamil. PMID: 25834318 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2015 Category: Gastroenterology Authors: Zhang JW, Zhang GX, Chen HL, Liu GL, Owusu L, Wang YX, Wang GY, Xu CM Tags: World J Gastroenterol Source Type: research