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MET inhibitors for treatment of advanced hepatocellular carcinoma: A review.
Abstract The current standard treatment option for advanced hepatocellular carcinoma (HCC) is sorafenib, but its clinical benefit is modest. In spite of many attempts, few drugs can provide any significant improvement of survival as the first- or second-line therapy of choice in phase III randomized controlled trials. Recently, the subgroup analysis of a phase II randomized controlled trial has shown that tivantinib, a selective MET inhibitor, can significantly improve the overall survival in patients with MET-positive advanced HCC after the failure or intolerance of a prior systemic therapy. These findings enlight...
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Qi XS, Guo XZ, Han GH, Li HY, Chen J Tags: World J Gastroenterol Source Type: research

Downregulation of rho-associated protein kinase 1 by miR-124 in colorectal cancer.
CONCLUSION: miR-124 promotes hyperplasia and contributes to invasion of CRC cells, but downregulates ROCK1. ROCK1 and miR-124 may play important roles in CRC. PMID: 25987767 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Xi ZW, Xin SY, Zhou LQ, Yuan HX, Wang Q, Chen KX Tags: World J Gastroenterol Source Type: research

Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice.
CONCLUSION: Our study indicated that PCB could be an ideal candidate for reversing acute liver injury or ALF. PMID: 25987768 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Liu J, Zhang QY, Yu LM, Liu B, Li MY, Zhu RZ Tags: World J Gastroenterol Source Type: research

Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice.
CONCLUSION: These findings demonstrate that DHM alleviates CCl4-induced liver injury, suggesting that DHM is a promising candidate for reversing liver injury and ALF. PMID: 25987769 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Xie J, Liu J, Chen TM, Lan Q, Zhang QY, Liu B, Dai D, Zhang WD, Hu LP, Zhu RZ Tags: World J Gastroenterol Source Type: research

Hemodynamics and vasoactive substance levels during renal congestion that occurs in the anhepatic phase of liver transplantation.
CONCLUSION: In the anhepatic phase of orthotopic liver transplantation, renal vein congestion significantly impacts hemodynamic parameters, which correlate with serum BK and ANGII levels. PMID: 25987770 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Li ZX, Wang MC, Zhang YC, Mao J, Chen M, Ni R, Wei FX, Wang GN, Zhang LY Tags: World J Gastroenterol Source Type: research

Pancreas-sparing duodenectomy with regional lymph node dissection for early-stage ampullary carcinoma: A case control study using propensity scoring methods.
CONCLUSION: PSD with regional lymph node dissection presents an acceptable morbidity in addition to its advantages over PD. PSD may be a safe and feasible alternative to PD in the treatment of early-stage Amp Ca. PMID: 25987771 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Liu B, Li J, Zhang YJ, Yan LN, You SY, Lau WY, Sun HR, Yan SY, Wang ZQ Tags: World J Gastroenterol Source Type: research

Relevance of low viral load in haemodialysed patients with chronic hepatitis C virus infection.
CONCLUSION: Haemodialysis decreases the viral load, especially in IL28B CC genotype carriers. A low IVL was the strongest predictor of SVR in ESRD patients identified in multivariate analysis. PMID: 25987772 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Sperl J, Frankova S, Senkerikova R, Neroldova M, Hejda V, Volfova M, Merta D, Viklicky O, Spicak J, Jirsa M Tags: World J Gastroenterol Source Type: research

Long-term oncologic outcomes of laparoscopic vs open surgery for stages II and III rectal cancer: A retrospective cohort study.
CONCLUSION: LRR for stages II and III rectal cancer can yield comparable long-term survival while achieving short-term benefits compared to open surgery. PMID: 25987773 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Zhou ZX, Zhao LY, Lin T, Liu H, Deng HJ, Zhu HL, Yan J, Li GX Tags: World J Gastroenterol Source Type: research

High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis.
CONCLUSION: The incorporation of HRME into an ESCC screening program could be cost-effective in China. Larger studies of HRME performance are needed to confirm these findings. PMID: 25987774 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Hur C, Choi SE, Kong CY, Wang GQ, Xu H, Polydorides AD, Xue LY, Perzan KE, Tramontano AC, Richards-Kortum RR, Anandasabapathy S Tags: World J Gastroenterol Source Type: research

Similar efficacy and safety of tenofovir in Asians and non-Asians with chronic hepatitis B.
CONCLUSION: TDF demonstrated similar viral suppression, normalization of ALT, improvements in liver fibrosis, and no detectable resistance in Asian and non-Asian patients regardless of baseline HBeAg status. PMID: 25987775 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Pan CQ, Chan S, Trinh H, Yao A, Bae H, Lou L Tags: World J Gastroenterol Source Type: research

Psychosocial mechanisms for the transmission of somatic symptoms from parents to children.
CONCLUSION: Multiple factors influence the reporting of children's gastrointestinal and non-gastrointestinal symptoms. The clustering of illness within families is best understood using a model that incorporates all these factors. PMID: 25987776 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: van Tilburg MA, Levy RL, Walker LS, Von Korff M, Feld LD, Garner M, Feld AD, Whitehead WE Tags: World J Gastroenterol Source Type: research

Comparison of the diagnostic yield and outcomes between standard 8 h capsule endoscopy and the new 12 h capsule endoscopy for investigating small bowel pathology.
CONCLUSION: In our study, we found the PillCam SB2-ex to have a significantly increased completion rate, though without any improvement in diagnostic yield compared to the PillCam SB2. PMID: 25987777 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Rahman M, Akerman S, DeVito B, Miller L, Akerman M, Sultan K Tags: World J Gastroenterol Source Type: research

Phagocytosis (cannibalism) of apoptotic neutrophils by tumor cells in gastric micropapillary carcinomas.
CONCLUSION: This is the first study showing phagocytosis (cannibalism) of apoptotic neutrophils by tumor cells in gastric micropapillary carcinomas. PMID: 25987778 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Barresi V, Branca G, Ieni A, Rigoli L, Tuccari G, Caruso RA Tags: World J Gastroenterol Source Type: research

Effectiveness of therapeutic barium enema for diverticular hemorrhage.
CONCLUSION: Therapeutic barium enema is effective for the control of diverticular hemorrhage in cases where the active bleeding site cannot be identified by colonoscopy. PMID: 25987779 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Matsuura M, Inamori M, Nakajima A, Komiya Y, Inoh Y, Kawasima K, Naitoh M, Fujita Y, Eduka A, Kanazawa N, Uchiyama S, Tani R, Kawana K, Ohtani S, Nagase H Tags: World J Gastroenterol Source Type: research

Endoscopic and biopsy diagnoses of superficial, nonampullary, duodenal adenocarcinomas.
CONCLUSION: Preoperative endoscopy and biopsy showed similar accuracies in the diagnosis of carcinoma in patients with superficial NADETs. PMID: 25987780 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Kakushima N, Kanemoto H, Sasaki K, Kawata N, Tanaka M, Takizawa K, Imai K, Hotta K, Matsubayashi H, Ono H Tags: World J Gastroenterol Source Type: research

Efficacy of 14-d vs 7-d moxifloxacin-based triple regimens for second-line Helicobacter pylori eradication.
CONCLUSION: The 14-d moxifloxacin-based triple therapy is a significantly more effective second-line eradication treatment as compared to the 7-d alternative for H. pylori infection in South Korea. PMID: 25987781 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Hwang JJ, Lee DH, Lee AR, Yoon H, Shin CM, Park YS, Kim N Tags: World J Gastroenterol Source Type: research

Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?
CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB. PMID: 25987782 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Kekilli M, Tanoglu A, Sakin YS, Kurt M, Ocal S, Bagci S Tags: World J Gastroenterol Source Type: research

Inflammation scores predict survival for hepatitis B virus-related hepatocellular carcinoma patients after transarterial chemoembolization.
CONCLUSION: The prognostic ability of GPS is superior to other inflammation scores for HCC patients undergoing TACE. Combining GPS and CLIP improved the prognostic power for OS. PMID: 25987783 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Zhou DS, Xu L, Luo YL, He FY, Huang JT, Zhang YJ, Chen MS Tags: World J Gastroenterol Source Type: research

Prognostic role of neutrophil-lymphocyte ratio in operable esophageal squamous cell carcinoma.
CONCLUSION: Preoperative serum NLR is a useful prognostic marker to complement TNM staging for operable ESCC patients, particularly in patients with stage IIIA disease. PMID: 25987784 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Duan H, Zhang X, Wang FX, Cai MY, Ma GW, Yang H, Fu JH, Tan ZH, Meng YQ, Fu XY, Ma QL, Lin P Tags: World J Gastroenterol Source Type: research

Poor oncologic outcomes of hepatocellular carcinoma patients with intra-abdominal infection after hepatectomy.
CONCLUSION: Postoperative intra-abdominal infection adversely affected oncologic outcomes, and the change in postoperative neutrophil-to-lymphocyte ratio was a good indicator of tumor recurrence in hepatocellular carcinoma patients after curative hepatectomy. PMID: 25987785 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Ruan DY, Lin ZX, Li Y, Jiang N, Li X, Wu DH, Wang TT, Chen J, Lin Q, Wu XY Tags: World J Gastroenterol Source Type: research

Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence.
CONCLUSION: PLT and PLT-based noninvasive models are effective tools for predicting postoperative recurrence, especially late recurrence. Larger cohorts are needed to validate our findings. PMID: 25987786 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Pang Q, Zhang JY, Xu XS, Song SD, Qu K, Chen W, Zhou YY, Miao RC, Liu SS, Dong YF, Liu C Tags: World J Gastroenterol Source Type: research

Effect of peroral esophageal myotomy for achalasia treatment: A Chinese study.
CONCLUSION: POEM can relieve achalasia symptoms, improve gastroesophageal junction relaxation and restore esophageal body motility function, but not normal esophageal peristalsis. PMID: 25987787 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Lu B, Li M, Hu Y, Xu Y, Zhang S, Cai LJ Tags: World J Gastroenterol Source Type: research

Diagnosis and surgical treatment of esophageal gastrointestinal stromal tumors.
CONCLUSION: Surgery is the standard, effective and successful treatment for esophageal GISTs. Long-term follow-up is required to monitor recurrence and metastasis. PMID: 25987788 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Zhang FB, Shi HC, Shu YS, Shi WP, Lu SC, Zhang XY, Tu SS Tags: World J Gastroenterol Source Type: research

Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.
CONCLUSION: We demonstrate HCN channel expression in human colon for the first time. Reduced HCN3 expression in aganglionic bowel suggests its potential role in HSCR pathophysiology. PMID: 25987789 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: O'Donnell AM, Coyle D, Puri P Tags: World J Gastroenterol Source Type: research

Association of erectile dysfunction with depression in patients with chronic viral hepatitis.
CONCLUSION: Patients with chronic viral hepatitis have a high prevalence of ED. Age and depression are independent factors for ED in male patients with chronic viral hepatitis. PMID: 25987790 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Ma BO, Shim SG, Yang HJ Tags: World J Gastroenterol Source Type: research

Vitamin D in addition to peg-interferon-alpha/ribavirin in chronic hepatitis C virus infection: ANRS-HC25-VITAVIC study.
CONCLUSION: Addition of vitamin D to PegIFN/RBV does not improve the rate of early virologic response in previously null-responders with chronic genotype 1 or 4 HCV infection. PMID: 25987791 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Terrier B, Lapidus N, Pol S, Serfaty L, Ratziu V, Asselah T, Thibault V, Souberbielle JC, Carrat F, Cacoub P Tags: World J Gastroenterol Source Type: research

Ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging.
CONCLUSION: Adding AFP and ascites to the BCLC staging classification can improve prognosis prediction for early and intermediate stages of hepatocellular carcinoma. PMID: 25987792 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Gomaa AI, Al-Khatib A, Abdel-Razek W, Hashim MS, Waked I Tags: World J Gastroenterol Source Type: research

Association of Streptococcus bovis presence in colonic content with advanced colonic lesion.
CONCLUSION: There is an association between S. bovis bacteremia and malignant colonic lesions; this should prompt for development of a reliable screening method for advanced colonic lesions. PMID: 25987793 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Paritsky M, Pastukh N, Brodsky D, Isakovich N, Peretz A Tags: World J Gastroenterol Source Type: research

Models for predicting hepatitis B e antigen seroconversion in response to interferon-α in chronic hepatitis B patients.
CONCLUSION: Models with good negative and positive predictive values were developed to calculate the probability of response to IFN-α therapy. PMID: 25987794 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Wang CT, Zhang YF, Sun BH, Dai Y, Zhu HL, Xu YH, Lu MJ, Yang DL, Li X, Zhang ZH Tags: World J Gastroenterol Source Type: research

Self-reported dietary fructose intolerance in irritable bowel syndrome: Proposed diagnostic criteria.
CONCLUSION: FRD improves symptoms in a subgroup of IBS patients. A diet trial followed by a provocation test evaluated by SGA can identify most responders to FRD. PMID: 25987795 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Berg LK, Fagerli E, Myhre AO, Florholmen J, Goll R Tags: World J Gastroenterol Source Type: research

Oral mixture of autologous colon-extracted proteins for the Crohn's disease: A double-blind trial.
CONCLUSION: Oral administration of the autologous colonic extract could be a safe and effective for the treatment of patients with moderate to severe Crohn's disease. PMID: 25987796 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Israeli E, Zigmond E, Lalazar G, Klein A, Hemed N, Goldin E, Ilan Y Tags: World J Gastroenterol Source Type: research

Prevalence of fatty liver disease and the economy in China: A systematic review.
CONCLUSION: This study reveals a correlation between the economy and the prevalence of FLD in mainland China. PMID: 25987797 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Zhu JZ, Zhou QY, Wang YM, Dai YN, Zhu J, Yu CH, Li YM Tags: World J Gastroenterol Source Type: research

Association of IL-17 polymorphisms with gastric cancer risk in Asian populations.
CONCLUSION: The IL-17 gene may be significantly correlated with gastric cancer risk in Asian populations, especially those carrying the rs2275913 G>A and rs763780 T>C polymorphisms. PMID: 25987798 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Long ZW, Yu HM, Wang YN, Liu D, Chen YZ, Zhao YX, Bai L Tags: World J Gastroenterol Source Type: research

Systematic review and meta-analysis of prophylactic abdominal drainage after pancreatic resection.
CONCLUSION: Prophylactic abdominal drainage after pancreatic resection is still necessary, though more evidence from randomized controlled trials assessing prophylactic drainage after PD and distal pancreatectomy are needed. PMID: 25987799 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Dou CW, Liu ZK, Jia YL, Zheng X, Tu KS, Yao YM, Liu QG Tags: World J Gastroenterol Source Type: research

Left ventricular assist device hemolysis leading to dysphagia.
Abstract A 41-year-old man with a continuous-flow left ventricular assist device presented for evaluation of dysphagia and dark urine. He was found to have a significantly elevated L-lactate dehydrogenase and an elevated plasma free hemoglobin consistent with intravascular hemolysis. After the hemolysis ceased, both the black urine and dysphagia resolved spontaneously. Transient esophageal dysfunction, as a manifestation of gastrointestinal dysmotility, is known to occur in the setting of hemolysis. Paroxysmal nocturnal hemoglobinuria is another recognized cause of massive hemolysis with gastrointestinal dysmotilit...
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Wuschek A, Iqbal S, Estep J, Quigley E, Richards D Tags: World J Gastroenterol Source Type: research

Esophageal subepithelial lesion diagnosed as malignant gastrointestinal neuroectodermal tumor.
Abstract A 21-year-old male visited our hospital with a complaint of aggravating dysphagia and odynophagia for a few days. Esophagogastroduodenoscopy showed huge bulging mucosa with an intact surface causing luminal narrowing at 35 cm from the incisor teeth. Endoscopic ultrasonography showed an about 35 mm sized irregular margined in-homogenous hypoechoic lesion with an obscure layer of origin. Endoscopic ultrasonography fine needle aspiration revealed spindle cell proliferation without immunoreactivity for CD117, SMA, and cytokeratin. The patient underwent excision of the subepithelial lesion at the distal esophag...
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Kim SB, Lee SH, Gu MJ Tags: World J Gastroenterol Source Type: research

Therapeutic endoscopic retrograde cholangiopancreatography in a patient with situs inversus viscerum.
We report a new case of a 70-year-old Chinese male with total SIV who had obstructive jaundice. Magnetic resonance cholangiopancreatography demonstrated a number of stones in the gallbladder and common bile duct (CBD). Therapeutic ERCP was performed to relieve biliary obstruction and remove the CBD stones. This procedure started with the patient in a supine position and the endoscopist at the left side of the table. When the papilla was maintained, the patient was repositioned to a prone position and standard endoscopic sphincterotomy and endoscopic papillary balloon dilatation procedures were conducted. ERCP was performed...
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Hu Y, Zeng H, Pan XL, Lv NH, Liu ZJ, Hu Y Tags: World J Gastroenterol Source Type: research

Transjugular intrahepatic portosystemic shunt as bridge-to-surgery in refractory gastric antral vascular ectasia.
We report the case of a 67-year-old cirrhotic patient who presented with GAVE related GIB, unresponsive to multiple endoscopic treatments. The patient had a good liver function (model for end-stage disease 10). After a multidisciplinary meeting, a transjugular intrahepatic portosystemic shunt (TIPS) procedure was performed, in order to treat the cirrhosis associated ascites. The outcome was successful. An antrectomy was then performed, with no recurrence of GIB and no transfusion need during three months of follow up. In this case, the TIPS procedure achieved a complete ascites regression, allowing a safer surgical treatme...
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Becq A, Ozenne V, Plessier A, Valleur P, Dray X Tags: World J Gastroenterol Source Type: research

Are children on jejunal feeds at risk of iron deficiency?
We describe the biochemical and hematological features of six children on exclusive jejunal feeding who did not receive iron supplementation. At a mean (standard deviation) period of 11 (6.5) mo after commencing jejunal feeds, there was a significant reduction in both serum iron (18.5 g/L vs 9.8 g/L, P = 0.01) and transferrin saturation levels (23.1% vs 13.7%, P = 0.02), suggesting iron deficiency. However, there was no significant change in ferritin, hemoglobin and mean corpuscular volume levels post-commencement of jejunal feeds. This may be the result of small bowel adaptation in response to early iron deficiency. Large...
Source: World Journal of Gastroenterology : WJG - May 14, 2015 Category: Gastroenterology Authors: Tan LZ, Adams SE, Kennedy A, Kepreotes H, Ooi CY Tags: World J Gastroenterol Source Type: research

Review on hepatic explant pathology of pediatric intestinal transplant recipients: Is it time for an oil change?
Abstract A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product Omegaven™. The authors have shown from explant livers of children on chronic parenteral nutrition with Omegaven™ that biochemical improvement in cholestasis does not always reflect improvement in liver histology. These findings support 2 small case series that were previously published. Despite improvement and resolution of hyperbilirubinemia in all six infants, five of six infants had persistent or progressive hepatic fibrosis, while only one infant had regression of fibrosis. The st...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Imseis E, Rhoads JM Tags: World J Gastroenterol Source Type: research

Wireless endoscopy in 2020: Will it still be a capsule?
Abstract Currently, the major problem of all existing commercial capsule devices is the lack of control of movement. In the future, with an interface application, the clinician will be able to stop and direct the device into points of interest for detailed inspection/diagnosis, and therapy delivery. This editorial presents current commercially-available new designs, European projects and delivery capsule and gives an overview of the progress required and progress that will be achieved -according to the opinion of the authors- in the next 5 year leading to 2020. PMID: 25954085 [PubMed - in process] (Source: Wor...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Koulaouzidis A, Iakovidis DK, Karargyris A, Rondonotti E Tags: World J Gastroenterol Source Type: research

Liver plays a central role in asymmetric dimethylarginine-mediated organ injury.
Abstract Asymmetric-dimethylarginine (ADMA) competes with L-arginine for each of the three isoforms of nitric oxide synthase: endothelial; neuronal; inducible. ADMA is synthesized by protein methyltransferases followed by proteolytic degradation. ADMA is metabolized to citrulline and dimethylamine, by dimethylarginine dimethylaminohydrolase (DDAH) and enters cells through cationic amino-acid transporters extensively expressed in the liver. The liver plays a crucial role in ADMA metabolism by DDAH-1 and, as has been recently demonstrated, it is also responsible for ADMA biliary excretion. A correlation has been demo...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Ferrigno A, Di Pasqua LG, Berardo C, Richelmi P, Vairetti M Tags: World J Gastroenterol Source Type: research

Reversibility and heritability of liver fibrosis: Implications for research and therapy.
Abstract Liver fibrosis continues to be a major health problem worldwide due to lack of effective therapy. If the etiology cannot be eliminated, liver fibrosis progresses to cirrhosis and eventually to liver failure or malignancy; both are associated with a fatal outcome. Liver transplantation, the only curative therapy, is still mostly unavailable. Liver fibrosis was shown to be a reversible process; however, complete reversibility remains debatable. Recently, the molecular markers of liver fibrosis were shown to be transmitted across generations. Epigenetic mechanisms including DNA methylation, histone posttransl...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Atta HM Tags: World J Gastroenterol Source Type: research

Non-polypoid colorectal neoplasms: Classification, therapy and follow-up.
Abstract In the last years, an increasing interest has been raised on non-polypoid colorectal tumors (NPT) and in particular on large flat neoplastic lesions beyond 10 mm tending to grow laterally, called laterally spreading tumors (LST). LSTs and large sessile polyps have a greater frequency of high-grade dysplasia and local invasiveness as compared to pedunculated lesions of the same size and usually represent a technical challenge for the endoscopist in terms of either diagnosis and resection. According to the Paris classification, NPTs are distinguished in slightly elevated (0-IIa, less than 2.5 mm), flat (0-II...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Facciorusso A, Antonino M, Di Maso M, Barone M, Muscatiello N Tags: World J Gastroenterol Source Type: research

Chemotherapy for colorectal cancer in the elderly.
Abstract Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the elderly. However, elderly patients with CRC tend to be under-presented in clinical trials and undertreated in clinical practice. Advanced age alone should not be the only criteria to preclude effective therapy in elderly patients with CRC. The best guide about optimal cancer treatment can be provided by comprehensive geriatric assessment. Elderly patients with stage III colon cancer can enjoy the same benefit from adjuvant chemotherapy with 5-fluorouracil/leucovorin or capecitabine as younger patients, without a substantial...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Kim JH Tags: World J Gastroenterol Source Type: research

Sex- and gender-specific disparities in colorectal cancer risk.
The objective of this review is to suggest gender-based innovations to improve colorectal cancer outcomes in females. Women have a higher risk of developing right-sided (proximal) colon cancer than men, which is associated with more aggressive form of neoplasia compared to left-sided (distal) colon cancer. Despite differences in tumor location between women and men, most of scientific researchers do not consider sex specificity for study design and interpretation. Also, colorectal cancer screening guidelines do not distinguish females from male, which may explain the higher frequency of more advanced neoplasia when tumors ...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Kim SE, Paik HY, Yoon H, Lee JE, Kim N, Sung MK Tags: World J Gastroenterol Source Type: research

Learning models for endoscopic ultrasonography in gastrointestinal endoscopy.
Abstract Endoscopic ultrasonography (EUS) has become a useful diagnostic and therapeutic modality in gastrointestinal endoscopy. However, EUS requires additional training since it requires simultaneous endoscopic manipulation and ultrasonographic interpretation. Obtaining adequate EUS training can be challenging since EUS is highly operator-dependent and training on actual patients can be associated with an increased risk of complications including inaccurate diagnosis. Therefore, several models have been developed to help facilitate training of EUS. The models currently available for EUS training include computer-...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Kim GH, Bang SJ, Hwang JH Tags: World J Gastroenterol Source Type: research

Advances in understanding and treating liver diseases during pregnancy: A review.
Abstract Liver disease in pregnancy is rare but pregnancy-related liver diseases may cause threat to fetal and maternal survival. It includes pre-eclampsia; eclampsia; haemolysis, elevated liver enzymes, and low platelets syndrome; acute fatty liver of pregnancy; hyperemesis gravidarum; and intrahepatic cholestasis of pregnancy. Recent basic researches have shown the various etiologies involved in this disease entity. With these advances, rapid diagnosis is essential for severe cases since the decision of immediate delivery is important for maternal and fetal survival. The other therapeutic options have also been s...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Kamimura K, Abe H, Kawai H, Kamimura H, Kobayashi Y, Nomoto M, Aoyagi Y, Terai S Tags: World J Gastroenterol Source Type: research

Role of vitamins in gastrointestinal diseases.
Abstract A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases. For instance, most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials, however interventional trials failed to prove a clear beneficial preventive role. On the other hand, more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities. Examples for this include the therapeutic role of vita...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Masri OA, Chalhoub JM, Sharara AI Tags: World J Gastroenterol Source Type: research

From reflux esophagitis to Barrett's esophagus and esophageal adenocarcinoma.
Abstract The occurrence of gastroesophageal reflux disease is common in the human population. Almost all cases of esophageal adenocarcinoma are derived from Barrett's esophagus, which is a complication of esophageal adenocarcinoma precancerous lesions. Chronic exposure of the esophagus to gastroduodenal intestinal fluid is an important determinant factor in the development of Barrett's esophagus. The replacement of normal squamous epithelium with specific columnar epithelium in the lower esophagus induced by the chronic exposure to gastroduodenal fluid could lead to intestinal metaplasia, which is closely associate...
Source: World Journal of Gastroenterology : WJG - May 7, 2015 Category: Gastroenterology Authors: Wang RH Tags: World J Gastroenterol Source Type: research