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Neuropilins and liver.
Abstract Neuropilins (NRPs) are highly conserved transmembrane glycoproteins that possess pleiotropic functions. Neuropilin-1 (NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively. The contribution of NRPs to tumor angiogenesis has been highlighted in previous studies, leading to the development of NRP antagonists as novel anti-angiogenesis therapies. However, more recent studies have demonstrated that NRPs have a much broader spectrum of activity in the integration of di...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Elpek GÖ Tags: World J Gastroenterol Source Type: research

Unsolved problems and future perspectives of hepatitis B virus vaccination.
Abstract Hepatitis B virus (HBV) infection is still a serious worldwide problem, and vaccination is the most effective strategy for primary prevention of the infection. Although universal vaccination may be required for total eradication, several countries, including Japan, have not yet adopted universal vaccination programs. Some individuals are non-responders to HBV vaccine and several mechanisms responsible for their poor response have been proposed. To overcome non-response, third generation vaccines with pre-S proteins have been developed. These vaccines have shown better anti-HBs responses and may also be eff...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Tajiri K, Shimizu Y Tags: World J Gastroenterol Source Type: research

Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA.
Abstract Hepatitis B virus (HBV) infection is a major global health problem. Although current therapies, such as the use of nucleos(t)ide analogs, inhibit HBV replication efficiently, they do not eliminate covalently closed circular DNA (cccDNA), which persists in hepatocyte nuclei. As HBV cccDNA is a viral transcription template, novel therapeutic approaches to directly target HBV cccDNA are necessary to completely eradicate persistent HBV infections. HBV cccDNA levels in HBV-infected human liver cells are extremely low; thus, more reliable and simple measurement methods are needed to correctly monitor their level...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Ohno M, Otsuka M, Kishikawa T, Yoshikawa T, Takata A, Koike K Tags: World J Gastroenterol Source Type: research

Food allergy in irritable bowel syndrome: The case of non-celiac wheat sensitivity.
Abstract Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, having a prevalence of 12%-30% in the general population. Most patients with IBS attribute their symptoms to adverse food reactions. We review the role of diet in the pathogenesis of IBS and the importance of dietary factors in the management of these patients. The MEDLINE electronic database (1966 to Jan 2015) was searched using the following keywords: "food", "diet", "food allergy", "food hypersensitivity", "food intolerance", "IBS", "epidemiology", "pathogenesis", "pathophysiology", "diagnosis", "treatment". We found 15...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Mansueto P, D'Alcamo A, Seidita A, Carroccio A Tags: World J Gastroenterol Source Type: research

Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity.
Abstract Cereal crops and cereal consumption have had a vital role in Mankind's history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensiv...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Elli L, Branchi F, Tomba C, Villalta D, Norsa L, Ferretti F, Roncoroni L, Bardella MT Tags: World J Gastroenterol Source Type: research

Useful strategies to prevent severe stricture after endoscopic submucosal dissection for superficial esophageal neoplasm.
Abstract The minimal invasiveness of endoscopic submucosal dissection (ESD) prompted us to apply this technique to large-size early esophageal squamous cell carcinoma and Barrett's adenocarcinoma, despite the limitations in the study population and surveillance duration. A post-ESD ulceration of greater than three-fourths of esophageal circumference was advocated as an important risk factor for refractory strictures that require several sessions of dilation therapy. Most of the preoperative conditions are asymptomatic, but dilatation treatment for dysphagia associated with the stricture has potential risks of sever...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Uno K, Iijima K, Koike T, Shimosegawa T Tags: World J Gastroenterol Source Type: research

Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy.
Abstract Intrahepatic cholestasis of pregnancy (ICP) is a reversible pregnancy-specific cholestatic condition characterized by pruritus, elevated liver enzymes, and increased serum bile acids. It commences usually in the late second or third trimester, and quickly resolves after delivery. The incidence is higher in South American and Scandinavian countries (9.2%-15.6% and 1.5%, respectively) than in Europe (0.1%-0.2%). The etiology is multifactorial where genetic, endocrine, and environmental factors interact. Maternal outcome is usually benign, whereas fetal complications such as preterm labor, meconium staining, ...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Ozkan S, Ceylan Y, Ozkan OV, Yildirim S Tags: World J Gastroenterol Source Type: research

Molecular aspects of intestinal calcium absorption.
Abstract Intestinal Ca(2+) absorption is a crucial physiological process for maintaining bone mineralization and Ca(2+) homeostasis. It occurs through the transcellular and paracellular pathways. The first route comprises 3 steps: the entrance of Ca(2+) across the brush border membranes (BBM) of enterocytes through epithelial Ca(2+) channels TRPV6, TRPV5, and Cav1.3; Ca(2+) movement from the BBM to the basolateral membranes by binding proteins with high Ca(2+) affinity (such as CB9k); and Ca(2+) extrusion into the blood. Plasma membrane Ca(2+) ATPase (PMCA1b) and sodium calcium exchanger (NCX1) are mainly involved ...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Diaz de Barboza G, Guizzardi S, Tolosa de Talamoni N Tags: World J Gastroenterol Source Type: research

Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats.
CONCLUSION: Bicyclol significantly attenuates BDL-induced liver fibrosis by reversing fibrogenic gene expression. These findings suggest that bicyclol might be an effective anti-fibrotic drug for the treatment of cholestatic liver disease. PMID: 26109801 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Zhen YZ, Li NR, He HW, Zhao SS, Zhang GL, Hao XF, Shao RG Tags: World J Gastroenterol Source Type: research

Activated rat hepatic stellate cells influence Th1/Th2 profile in vitro.
CONCLUSION: Activated rat HSCs lower the Th1/Th2 profile, inhibiting the Th1 response and enhancing the Th2 response, and this may be a novel pathway for liver fibrogenesis. PMID: 26109802 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Xing ZZ, Huang LY, Wu CR, You H, Ma H, Jia JD Tags: World J Gastroenterol Source Type: research

Abundance and significance of neuroligin-1 and glutamate in Hirschsprung's disease.
CONCLUSION: Neuroligin-1 and Glu may represent new markers of ganglion cells, whose expression may correlate with the pathogenesis, diagnosis, differential diagnosis or classification of HSCR. PMID: 26109803 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Wang J, Du H, Mou YR, Niu JY, Zhang WT, Yang HC, Li AW Tags: World J Gastroenterol Source Type: research

Effects of electroacupuncture on corticotropin-releasing hormone in rats with chronic visceral hypersensitivity.
CONCLUSION: Electroacupuncture at the Shangjuxu acupoint was able to significantly reduce the visceral hypersensitivity in rats, and regulated the expression of CRH protein and mRNA in the colon, spinal cord and hypothalamus at different levels, playing a therapeutic role in this model of irritable bowel syndrome. PMID: 26109804 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Liu HR, Fang XY, Wu HG, Wu LY, Li J, Weng ZJ, Guo XX, Li YG Tags: World J Gastroenterol Source Type: research

β-2 Adrenergic receptor gene polymorphism and response to propranolol in cirrhosis.
CONCLUSION: The variceal pressure response to propranolol was associated with polymorphism of β2-AR gene. Patients with the Gly(16)-Glu/Gln(27) homozygotes probably benefit from propranolol therapy. PMID: 26109805 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Kong DR, Wang JG, Sun B, Wang MQ, Chen C, Yu FF, Xu JM Tags: World J Gastroenterol Source Type: research

Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling.
CONCLUSION: In summary, the in vitro data suggest that paeoniflorin is a potential novel therapeutic agent against gastric carcinoma, which inhibits cell viability and induces apoptosis through the up-regulation of miR-124 and suppression of PI3K/Akt and STAT3 signaling. PMID: 26109806 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Zheng YB, Xiao GC, Tong SL, Ding Y, Wang QS, Li SB, Hao ZN Tags: World J Gastroenterol Source Type: research

Long noncoding RNAs in hepatitis B virus-related hepatocellular carcinoma.
CONCLUSION: lncRNAs play important roles in HCC, future studies should verify whether large intergenic noncoding ULK4P2 functions by combining with enhancer of zeste homolog 2 in HCC. PMID: 26109807 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Yu TT, Xu XM, Hu Y, Deng JJ, Ge W, Han NN, Zhang MX Tags: World J Gastroenterol Source Type: research

Impact of body mass index on complications following pancreatectomy: Ten-year experience at National Cancer Center in China.
CONCLUSION: Higher BMI increases the risk for postoperative complications after pancreatectomy in the Chinese population. The findings require replication in future studies with larger sample sizes. PMID: 26109808 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Chen YT, Deng Q, Che X, Zhang JW, Chen YH, Zhao DB, Tian YT, Zhang YW, Wang CF Tags: World J Gastroenterol Source Type: research

Comparison of non-schistosomal rectosigmoid cancer and schistosomal rectosigmoid cancer.
CONCLUSION: Rectosigmoid carcinoma combined with schistosomiasis is associated with higher CA-125 values and early tumor stages. CA-125 and CT scans have a reasonable sensitivity for the accurate diagnosis. PMID: 26109809 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Feng H, Lu AG, Zhao XW, Han DP, Zhao JK, Shi L, Schiergens TS, Lee SM, Zhang WP, Thasler WE Tags: World J Gastroenterol Source Type: research

PillCam COLON 2(©) in Crohn's disease: A new concept of pan-enteric mucosal healing assessment.
CONCLUSION: Only three patients in sustained corticosteroid-free clinical remission achieved mucosal healing in both the small bowel and the colon, highlighting the limitations of clinical assessment when stratifying disease activity, and the need for pan-enteric endoscopy to guide therapeutic modification. PMID: 26109810 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Boal Carvalho P, Rosa B, Dias de Castro F, Moreira MJ, Cotter J Tags: World J Gastroenterol Source Type: research

Risk factors for small bowel angioectasia: The impact of visceral fat accumulation.
CONCLUSION: VFA is positively associated with the prevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB. PMID: 26109811 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Yamada A, Niikura R, Kobayashi Y, Suzuki H, Yoshida S, Watabe H, Yamaji Y, Hirata Y, Koike K Tags: World J Gastroenterol Source Type: research

Living donor liver transplantation with body-weight more or less than 10 kilograms.
CONCLUSION: Patients weighing less than 10 kg typically have poorer conditions, but their survival rates are comparable to those of children weighing more than 10 kg. PMID: 26109812 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Yang SC, Huang CJ, Chen CL, Wang CH, Wu SC, Shih TH, Juang SE, Lee YE, Jawan B, Cheng YF, Cheng KW Tags: World J Gastroenterol Source Type: research

High level of intercellular adhesion molecule-1 affects prognosis of patients with hepatocellular carcinoma.
CONCLUSION: ICAM-1 may be a promising serological biomarker for HCC diagnosis and an independent predictor of DFS and OS after surgical resection and may provide a useful reference for the prediction of intra- and extrahepatic metastasis. PMID: 26109813 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Zhu PP, Yuan SG, Liao Y, Qin LL, Liao WJ Tags: World J Gastroenterol Source Type: research

Autologous mobilized peripheral blood CD34(+) cell infusion in non-viral decompensated liver cirrhosis.
CONCLUSION: Autologous CD 34(+) cell infusion is safe and effectively improves liver function in the short term and may serve as a bridge to liver transplantation. PMID: 26109814 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Sharma M, Rao PN, Sasikala M, Kuncharam MR, Reddy C, Gokak V, Raju B, Singh JR, Nag P, Nageshwar Reddy D Tags: World J Gastroenterol Source Type: research

Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012.
CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and re-hospitalization. PMID: 26109815 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Golovics PA, Lakatos L, Mandel MD, Lovasz BD, Vegh Z, Kurti Z, Szita I, Kiss LS, Pandur T, Lakatos PL Tags: World J Gastroenterol Source Type: research

Bevacizumab plus XELOX as first-line treatment of metastatic colorectal cancer: The OBELIX study.
CONCLUSION: The efficacy of bevacizumab in combination with XELOX in terms of PFS in patients with aCRC or mCRC in Italy was confirmed, with acceptable toxicity. PMID: 26109816 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Antonuzzo L, Giommoni E, Pastorelli D, Latiano T, Pavese I, Azzarello D, Aieta M, Pastina I, Di Fabio F, Bertolini A, Corsi DC, Mogavero S, Angelini V, Pazzagli M, Di Costanzo F Tags: World J Gastroenterol Source Type: research

Is endoscopic papillary large balloon dilatation without endoscopic sphincterotomy effective?
CONCLUSION: EST before sphincteroplasty may be unnecessary in EPLBD. Further investigations are needed to verify the relationship between the presence or absence of balloon waist disappearance. PMID: 26109817 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Omuta S, Maetani I, Saito M, Shigoka H, Gon K, Tokuhisa J, Naruki M Tags: World J Gastroenterol Source Type: research

Different roles of capsule endoscopy and double-balloon enteroscopy in obscure small intestinal diseases.
CONCLUSION: CE and DBE each have their own advantages and disadvantages. The appropriate choice depends on the patient's age, tolerance, and clinical manifestations. Sometimes CE followed by DBE is necessary. PMID: 26109818 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Zhang ZH, Qiu CH, Li Y Tags: World J Gastroenterol Source Type: research

Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids: A randomized controlled trial.
CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. PMID: 26109819 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Hernández-Bernal F, Castellanos-Sierra G, Valenzuela-Silva CM, Catasús-Álvarez KM, Martínez-Serrano O, Lazo-Diago OC, Bermúdez-Badell CH, Causa-García JR, Domínguez-Suárez JE, Investigators PA Tags: World J Gastroenterol Source Type: research

Increased risk of second malignancy in pancreatic intraductal papillary mucinous tumors: Review of the literature.
CONCLUSION: The available Literature is unanimous in claiming IPMNs to be strongly associated with pancreatic and extrapancreatic malignancies. The consequences in IPMNs management are herein discussed. PMID: 26109820 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Baiocchi GL, Molfino S, Frittoli B, Pigozzi G, Gheza F, Gaverini G, Tarasconi A, Ricci C, Bertagna F, Grazioli L, Tiberio GA, Portolani N Tags: World J Gastroenterol Source Type: research

How to treat an extensive form of primary intestinal lymphangiectasia?
We report a case of a 42-year-old man with a rare disorder known as primary intestinal lymphangiectasia, which is characterized by dilated intestinal lymphatics that lead to the development of protein-losing enteropathy. The patient presented with a grand mal seizure caused by malabsorption-derived electrolytes and a protein disorder. Signs of the disease, including chronic diarrhea and peripheral edema, manifested 10 years ago, but a diagnosis was never made. The diagnosis was suspected because of the clinical manifestations, laboratory tests, imaging and endoscopic findings. Hyperemic and edematous mucosa of the small in...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Troskot R, Jurčić D, Bilić A, Gomerčić Palčić M, Težak S, Brajković I Tags: World J Gastroenterol Source Type: research

Hemorrhagic hemangioma in the liver: A case report.
Abstract Hemangioma is the most common type of benign tumor that arises in the liver. Although rupture and hemorrhage of hepatic hemangioma are rare complications, they can be the cause of mortality. The authors report a case of hemorrhagic hepatic hemangioma: in a 54-year-old woman who was admitted with epigastric pain. She had taken oral contraceptives several weeks prior. The results of a blood examination were normal. An abdominal computed tomography scan revealed a tumor in hepatic segment 4, and a hemorrhage inside the cystic mass was suspected. The mass was removed laparoscopically to confirm the tumor prope...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Kim JM, Chung WJ, Jang BK, Hwang JS, Kim YH, Kwon JH, Choi MS Tags: World J Gastroenterol Source Type: research

Citrin deficiency presenting as acute liver failure in an eight-month-old infant.
Abstract Citrin deficiency typically presents as neonatal intrahepatic cholestasis and resolves in late infancy. Here we report a case of citrin deficiency that presented as acute liver failure in late infancy in an apparently healthy child. The full-term male infant weighed 3400 g at birth, and exhibited normal development for eight months, at which time he contracted bronchial pneumonia. The infant developed jaundice and laboratory tests indicated elevated bilirubin and ammonia levels and an abnormal coagulation profile. Plasma amino acid analysis showed elevated levels of tyrosine, methionine, citrulline, and ar...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Zhang MH, Gong JY, Wang JS Tags: World J Gastroenterol Source Type: research

Primary combined hepatocellular-cholangiocellular sarcoma: An unusual case.
Abstract Primary liver carcinosarcoma is rare. Here we report an unusual case of liver carcinosarcoma containing combined hepatocellular cholangiocarcinoma. A mass in the right liver lobe of a 45-year-old man was accidentally discovered by ultrasonic inspection and computed tomography (CT) scan. Surgical resection was performed following a diagnosis of primary liver cancer. Micropathologically, both carcinomatous and sarcomatous elements were present, and diagnosis of liver carcinosarcoma was confirmed. The carcinomatous element consisted of hepatocellular carcinoma and foci of cholangiocellular carcinoma. The sarc...
Source: World Journal of Gastroenterology : WJG - June 21, 2015 Category: Gastroenterology Authors: Xiang S, Chen YF, Guan Y, Chen XP Tags: World J Gastroenterol Source Type: research

Portal vein thrombosis in cirrhosis: Controversies and latest developments.
Abstract Portal vein thrombosis (PVT) is encountered in liver cirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also catastrophic events such as acute intestinal ischaemia. Optimal management of PVT has not yet been addressed in any consensus publication. We review current literature on PVT in cirrhosis; its prevalence, pathophysiology, diagnosis, impact on the natural history of cirrhosis and liver transplantation, and management. Studies we...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Harding DJ, Perera MT, Chen F, Olliff S, Tripathi D Tags: World J Gastroenterol Source Type: research

Somatostatin analogs for gastric carcinoids: For many, but not all.
Abstract Gastric carcinoids (GCs) are classified as: type I, related to hypergastrinemia due to chronic atrophic gastritis (CAG), type II, associated with Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1, and type III, which is normogastrinemic. The management of type-I gastric carcinoids (GC1s) is still debated, because of their relatively benign course. According to the European Neuroendocrine Tumor Society guidelines endoscopic resection is indicated whenever possible; however, it is not often feasible because of the presence of a multifocal disease, large lesions, submucosal invasion or, ra...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Massironi S, Zilli A, Conte D Tags: World J Gastroenterol Source Type: research

Prognostication and response assessment in liver and pancreatic tumors: The new imaging.
Abstract Diffusion-weighted imaging (DWI), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and perfusion computed tomography (CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations. Nevertheless, the term "functional imaging" is commonly used to describe molecular imaging techniques, as positron emission tomography (PET) CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: De Robertis R, Tinazzi Martini P, Demozzi E, Puntel G, Ortolani S, Cingarlini S, Ruzzenente A, Guglielmi A, Tortora G, Bassi C, Pederzoli P, D'Onofrio M Tags: World J Gastroenterol Source Type: research

Exclusive enteral nutrition in children with Crohn's disease.
Abstract Exclusive enteral nutrition involves the use of a complete liquid diet, with the exclusion of normal dietary components for a defined period of time, as a therapeutic measure to induce remission in active Crohn's disease (CD). This very efficacious approach leads to high rates of remission, especially in children and adolescents newly diagnosed with CD. This intervention also results in mucosal healing, nutritional improvements and enhanced bone health. Whilst several recent studies have provided further elaboration of the roles of exclusive enteral nutrition in the management of CD, other reports have pro...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Day AS, Lopez RN Tags: World J Gastroenterol Source Type: research

What are the effects of proton pump inhibitors on the small intestine?
Abstract Generally, proton-pump inhibitors (PPIs) have great benefit for patients with acid related disease with less frequently occurring side effects. According to a recent report, PPIs provoke dysbiosis of the small intestinal bacterial flora, exacerbating nonsteroidal anti-inflammatory drug-induced small intestinal injury. Several meta-analyses and systematic reviews have reported that patients treated with PPIs, as well as post-gastrectomy patients, have a higher frequency of small intestinal bacterial overgrowth (SIBO) compared to patients who lack the aforementioned conditions. Furthermore, there is insuffic...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Fujimori S Tags: World J Gastroenterol Source Type: research

Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: An update.
Abstract Non-alcoholic fatty liver disease (NAFLD) is considered to be an independent cardiovascular disease (CVD) risk factor. However, simple steatosis has a benign clinical course without excess mortality. In contrast, the advanced form of NAFLD, non-alcoholic steatohepatitis (NASH) with liver fibrosis increases mortality by approximately 70%, due to an increase in CVD mortality by approximately 300%. Chronic kidney disease (CKD) may be caused by NAFLD/NASH and it substantially increases CVD risk, especially in the presence of type 2 diabetes mellitus. Moreover, CKD may trigger NAFLD/NASH deterioration in a vici...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Athyros VG, Tziomalos K, Katsiki N, Doumas M, Karagiannis A, Mikhailidis DP Tags: World J Gastroenterol Source Type: research

Predictive roles of intraoperative blood glucose for post-transplant outcomes in liver transplantation.
This report highlights some of the recent studies related to perioperative blood glucose management focused on LT and liver disease. PMID: 26078559 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Park CS Tags: World J Gastroenterol Source Type: research

Endoscopic treatment of gastroparesis.
Abstract Gastroparesis has traditionally been a largely medically managed disease with refractory symptoms typically falling under the umbrella of the surgical domain. Surgical options include, but are not limited to, gastrostomy, jejunostomy, pyloromyotomy, or pyloroplasty, and the Food and Drug Administration approved gastric electrical stimulation implantation. Endoscopic management of gastroparesis most commonly involves intrapyloric botulinum toxin injection; however, there exists a variety of endoscopic approaches on the horizon that have the potential to radically shift standard of care. Endoscopic managemen...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: McCarty TR, Rustagi T Tags: World J Gastroenterol Source Type: research

Minimally invasive treatment of pancreatic pseudocysts.
Abstract A pancreatic pseudocyst (PPC) is typically a complication of acute and chronic pancreatitis, trauma or pancreatic duct obstruction. The diagnosis of PPC can be made if an acute fluid collection persists for 4 to 6 wk and is enveloped by a distinct wall. Most PPCs regress spontaneously and require no treatment, whereas some may persist and progress until complications occur. The decision whether to treat a patient who has a PPC, as well as when and with what treatment modalities, is a difficult one. PPCs can be treated with a variety of methods: percutaneous catheter drainage (PCD), endoscopic transpapillar...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Zerem E, Hauser G, Loga-Zec S, Kunosić S, Jovanović P, Crnkić D Tags: World J Gastroenterol Source Type: research

Advances in the study of Lynch syndrome in China.
Abstract Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is an autosomal dominant genetic condition that has a high risk of colon cancer as well as other cancers due to inherited mutations in mismatch repair (MMR) genes. During the last decades, there have been great advances in research on Chinese Lynch syndrome. This review mainly focuses on the genetic basis, clinicopathologic features, diagnosis, intervention, chemoprevention, and surveillance of Lynch syndrome in China. In addition to frequently altered MMR genes, such as MLH1, MSH2, MSH6, and MLH3, other MMR-associated genes, such as ...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Lu JY, Sheng JQ Tags: World J Gastroenterol Source Type: research

Induction of endoplasmic reticulum-derived oxidative stress by an occult infection related S surface antigen variant.
CONCLUSION: Our data indicate that occult infection related HBsAg variants can lead to ER-derived oxidative stress and liver cell death in HuH-7 cells. PMID: 26078563 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Lee IK, Lee SA, Kim H, Won YS, Kim BJ Tags: World J Gastroenterol Source Type: research

Downregulation of microRNA-382 is associated with poor outcome of esophageal squamous cell carcinoma.
CONCLUSION: miR-382 levels are reverse-correlated with ESCC poor outcomes, suggesting that miR-382 could be a potential predictive biomarker for both prognosis and treatment of ESCC. PMID: 26078564 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Qi B, Lu JG, Yao WJ, Chang TM, Qin XG, Ji YH, Wang TY, Liu SG, Li HC, Liu YZ, Zhao BS Tags: World J Gastroenterol Source Type: research

Nonalcoholic fatty liver disease, spleen and psoriasis: New aspects of low-grade chronic inflammation.
CONCLUSION: This study shows a correlation between the SLD and the duration of psoriasis. PMID: 26078565 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Balato N, Napolitano M, Ayala F, Patruno C, Megna M, Tarantino G Tags: World J Gastroenterol Source Type: research

Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population.
CONCLUSION: These results provide evidence that known genetic variants associated with CRC risk confer risk for esophageal cancer, and may bring risk for other digestive system tumors. PMID: 26078566 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Geng TT, Xun XJ, Li S, Feng T, Wang LP, Jin TB, Hou P Tags: World J Gastroenterol Source Type: research

Clinicopathologic and molecular features associated with patient age in gastric cancer.
CONCLUSION: Gastric cancer is distinguishable between younger and older patients based on both clinicopathologic and molecular features, but stage is the most important predictor of prognosis. PMID: 26078567 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Seo JY, Jin EH, Jo HJ, Yoon H, Shin CM, Park YS, Kim N, Jung HC, Lee DH Tags: World J Gastroenterol Source Type: research

Medical training fails to prepare providers to care for patients with chronic hepatitis B infection.
CONCLUSION: Even in a high-risk region, both medical school and residency training have not adequately prepared physicians in the screening and management of CHB. PMID: 26078568 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Chao SD, Wang BM, Chang ET, Ma L, So SK Tags: World J Gastroenterol Source Type: research

Prognostic angiogenic markers (endoglin, VEGF, CD31) and tumor cell proliferation (Ki67) for gastrointestinal stromal tumors.
CONCLUSION: The IMVD cutoff values for the angiogenic markers CD105 and CD31, may be prognostic factors for GIST, in addition to VEGF and Ki67. PMID: 26078569 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Basilio-de-Oliveira RP, Nunes Pannain VL Tags: World J Gastroenterol Source Type: research

Assessment of liver fibrosis by Fibroscan as compared to liver biopsy in biliary atresia.
CONCLUSION: Fibroscan can be used as a non-invasive technique to assess liver fibrosis in children with BA. The cut-off value of LSM (15.15 kPa) can distinguish cirrhotic patients from non-cirrhotic patients. PMID: 26078570 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Shen QL, Chen YJ, Wang ZM, Zhang TC, Pang WB, Shu J, Peng CH Tags: World J Gastroenterol Source Type: research