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Hepatitis C virus-mediated angiogenesis: Molecular mechanisms and therapeutic strategies.
Abstract Angiogenesis is an essential process for organ growth and repair. Thus, an imbalance in this process can lead to several diseases including malignancy. Angiogenesis is a critical step in vascular remodeling, tissue damage and wound healing besides being required for invasive tumor growth and metastasis. Because angiogenesis sets an important point in the control of tumor progression, its inhibition is considered a valuable therapeutic approach for tumor treatment. Chronic liver disease including hepatitis C virus (HCV) infection is one of the main cause for the development of hepatic angiogenesis and there...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Hassan M, Selimovic D, El-Khattouti A, Soell M, Ghozlan H, Haikel Y, Abdelkader O, Megahed M Tags: World J Gastroenterol Source Type: research

Diagnostic tests for hepatitis C: Recent trends in electrochemical immunosensor and genosensor analysis.
Abstract Hepatitis C is a liver disease that is transmitted through contact with the blood of an infected person. An estimated 150 million individuals worldwide have been chronically infected with the hepatitis C virus (HCV). Hepatitis C shows significant genetic variation in the global population, due to the high rate of viral RNA mutation. There are six variants of the virus (HCV genotypes 1, 2, 3, 4, 5, and 6), with 15 recorded subtypes that vary in prevalence across different regions of the world. A variety of devices are used to diagnose hepatitis C, including HCV antibody test, HCV viral load test, HCV genoty...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Uliana CV, Riccardi CS, Yamanaka H Tags: World J Gastroenterol Source Type: research

Cirrhotic cardiomyopathy: A cardiologist's perspective.
Abstract Cardiac dysfunction is frequently observed in patients with cirrhosis, and has long been linked to the direct toxic effect of alcohol. Cirrhotic cardiomyopathy (CCM) has recently been identified as an entity regardless of the cirrhosis etiology. Increased cardiac output due to hyperdynamic circulation is a pathophysiological hallmark of the disease. The underlying mechanisms involved in pathogenesis of CCM are complex and involve various neurohumoral and cellular pathways, including the impaired β-receptor and calcium signaling, altered cardiomyocyte membrane physiology, elevated sympathetic nervous tone ...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Gassanov N, Caglayan E, Semmo N, Massenkeil G, Er F Tags: World J Gastroenterol Source Type: research

Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects.
Abstract In addition to complications relating to the liver, patients with cirrhosis and portal hypertension develop extrahepatic functional disturbances of multiple organ systems. This can be considered a multiple organ failure that involves the heart, lungs, kidneys, the immune systems, and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. This affects both the haemodynamic and functional homeostasis of many organs and largely determines the course of the disease. With the progression of the disease, the circula...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Møller S, Henriksen JH, Bendtsen F Tags: World J Gastroenterol Source Type: research

Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease.
Abstract The incidence of obesity and its related conditions, including non-alcoholic fatty liver disease (NAFLD), has dramatically increased in all age groups worldwide. Given the health consequences of these conditions, and the subsequent economic burden on healthcare systems, their prevention and treatment have become major priorities. Because standard dietary and lifestyle changes and pathogenically-oriented therapies (e.g., antioxidants, oral hypoglycemic agents, and lipid-lowering agents) often fail due to poor compliance and/or lack of efficacy, novel approaches directed toward other pathomechanisms are need...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Paolella G, Mandato C, Pierri L, Poeta M, Di Stasi M, Vajro P Tags: World J Gastroenterol Source Type: research

Liver transplantation and non-alcoholic fatty liver disease.
Abstract Non-alcoholic fatty liver disease (NAFLD) is an important health problem worldwide. NAFLD encompasses a histological spectrum ranging from bland liver steatosis to severe steatohepatitis (nonalcoholic steatohepatitis, NASH) with the potential of progressing to cirrhosis and its associated morbidity and mortality. NAFLD is thought to be the hepatic manifestation of insulin resistance (or the metabolic syndrome); its prevalence is increasing worldwide in parallel with the obesity epidemic. In many developed countries, NAFLD is the most common cause of liver disease and NASH related cirrhosis is currently the...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Zezos P, Renner EL Tags: World J Gastroenterol Source Type: research

Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
In this report, we review the histopathological features of NAFLD/NASH. PMID: 25400438 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Takahashi Y, Fukusato T Tags: World J Gastroenterol Source Type: research

Contrast-enhanced harmonic endoscopic ultrasound imaging: Basic principles, present situation and future perspectives.
Abstract Over the last decade, the development of stabilised microbubble contrast agents and improvements in available ultrasonic equipment, such as harmonic imaging, have enabled us to display microbubble enhancements on a greyscale with optimal contrast and spatial resolution. Recent technological advances made contrast harmonic technology available for endoscopic ultrasound (EUS) for the first time in 2008. Thus, the evaluation of microcirculation is now feasible with EUS, prompting the evolution of contrast-enhanced EUS from vascular imaging to images of the perfused tissue. Although the relevant experience is ...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Alvarez-Sánchez MV, Napoléon B Tags: World J Gastroenterol Source Type: research

Neoadjuvant therapy for pancreas cancer: Past lessons and future therapies.
Abstract Pancreatic adenocarcinoma remains a most deadly malignancy, with an overall 5-year survival of 5%. A subset of patients will be diagnosed with potentially resectable disease, and while complete surgical resection provides the only chance at cure, data from trials of postoperative chemoradiation and/or chemotherapy demonstrate a modest survival advantage over those patients who undergo resection alone. As such, most practitioners believe that completion of multimodality therapy is the optimal treatment. However, the sequence of surgery, chemotherapy and radiation therapy is frequently debated, as patients m...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Sutton JM, Abbott DE Tags: World J Gastroenterol Source Type: research

Utility of PET/CT in diagnosis, staging, assessment of resectability and metabolic response of pancreatic cancer.
Abstract Pancreatic cancer is one of the most common gastrointestinal tumors, with its incidence staying at a high level in both the United States and China. However, the overall 5-year survival rate of pancreatic cancer is still extremely low. Surgery remains the only potential chance for long-term survival. Early diagnosis and precise staging are crucial to make proper clinical decision for surgery candidates. Despite advances in diagnostic technology such as computed tomography (CT) and endoscopic ultrasound, diagnosis, staging and monitoring of the metabolic response remain a challenge for this devastating dise...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Wang XY, Yang F, Jin C, Fu DL Tags: World J Gastroenterol Source Type: research

Laparoscopic liver resection for living donation: Where do we stand?
Abstract In Western countries, living donor liver transplantation (LDLT) may represent a valuable alternative to deceased donor liver transplantation. Yet, after an initial peak of enthusiasm, reports of high rates of complications and of fatalities have led to a certain degree of reluctance towards this procedure especially in Western countries. As for living donor kidney transplantation, the laparoscopic approach could improve patient's tolerance in order to rehabilitate this strategy and reverse the current trend. In this setting however, initial concerns regarding patient's safety and graft integrity, need for ...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Cauchy F, Schwarz L, Scatton O, Soubrane O Tags: World J Gastroenterol Source Type: research

Single port laparoscopy in gastroenterology and hepatology: A fine step forward.
Abstract Single incision laparoscopy (SIL) has become an emerging technology aiming at a further reduction of abdominal wall trauma in minimally invasive surgery. Available data is encouraging for the safe application of standardized SIL in a wide range of procedures in gastroenterology and hepatology. Compared to technically simple SIL procedures, the merit of SIL in advanced surgeries, such as liver or colorectal interventions, compared to conventional laparsocopy is self-evident without any doubt. SIL has already passed the learning curve and is routinely utilized in expert centers. This minimized approach has a...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Mittermair C, Schirnhofer J, Brunner E, Pimpl K, Obrist C, Weiss M, Weiss HG Tags: World J Gastroenterol Source Type: research

Laparoscopic resection of gastrointestinal neuroendocrine tumors with special contribution of radionuclide imaging.
Abstract The surgical treatment of neuroendocrine tumors (NETs) draws on experience and guidelines more than on prospective randomized trials. The incidence of NET is increasing in all parts of the gastrointestinal tract. A variety of classifications introduced over the last decade may have led to difficulties in judging clinical relevance and determining the right surgical strategy. The North American Neuroendocrine Tumor Society and the European Neuroendocrine Tumor Society have developed usable guidelines from the available literature. For more than 20 years laparoscopy has developed as the gold standard for var...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Shamiyeh A, Gabriel M Tags: World J Gastroenterol Source Type: research

Bowel endometriosis: Colorectal surgeon's perspective in a multidisciplinary surgical team.
Abstract Endometriosis is a gynecological condition that presents as endometrial-like tissue outside the uterus and induces a chronic inflammatory reaction. Up to 15% of women in their reproductive period are affected by this condition. Deep endometriosis is defined as endometriosis located more than 5 mm beneath the peritoneal surface. This type of endometriosis is mostly found on the uterosacral ligaments, inside the rectovaginal septum or vagina, in the rectosigmoid area, ovarian fossa, pelvic peritoneum, ureters, and bladder, causing a distortion of the pelvic anatomy. The frequency of bowel endometriosis is un...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Wolthuis AM, Meuleman C, Tomassetti C, D'Hooghe T, de Buck van Overstraeten A, D'Hoore A Tags: World J Gastroenterol Source Type: research

Gut microbiota-related complications in cirrhosis.
Abstract Gut microbiota plays an important role in cirrhosis. The liver is constantly challenged with commensal bacteria and their products arriving through the portal vein in the so-called gut-liver axis. Bacterial translocation from the intestinal lumen through the intestinal wall and to mesenteric lymph nodes is facilitated by intestinal bacterial overgrowth, impairment in the permeability of the intestinal mucosal barrier, and deficiencies in local host immune defences. Deranged clearance of endogenous bacteria from portal and systemic circulation turns the gut into the major source of bacterial-related complic...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Gómez-Hurtado I, Such J, Sanz Y, Francés R Tags: World J Gastroenterol Source Type: research

Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics.
Abstract The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probiotics as live microorganisms that confer a health benefit to the host when administered in adequate amounts. However, dead bacteria and bacterial molecular components may also exhibit probiotic properties. The results of clinical studies have demonstrated the clinical potential of probiotics in many pathologies, such as allergic diseases, diarrhea, inflammatory bowel disease and viral infection. ...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Plaza-Diaz J, Gomez-Llorente C, Fontana L, Gil A Tags: World J Gastroenterol Source Type: research

Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity.
Abstract Intestinal alkaline phosphatase (IAP) plays an essential role in intestinal homeostasis and health through interactions with the resident microbiota, diet and the gut. IAP's role in the intestine is to dephosphorylate toxic microbial ligands such as lipopolysaccharides, unmethylated cytosine-guanosine dinucleotides and flagellin as well as extracellular nucleotides such as uridine diphosphate. IAP's ability to detoxify these ligands is essential in protecting the host from sepsis during acute inflammation and chronic inflammatory conditions such as inflammatory bowel disease. Also important in these compli...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Estaki M, DeCoffe D, Gibson DL Tags: World J Gastroenterol Source Type: research

Enteric microbiota leads to new therapeutic strategies for ulcerative colitis.
Abstract Ulcerative colitis (UC) is a leading form of inflammatory bowel disease that involves chronic relapsing or progressive inflammation. As a significant proportion of UC patients treated with conventional therapies do not achieve remission, there is a pressing need for the development of more effective therapies. The human gut contains a large, diverse, and dynamic population of microorganisms, collectively referred to as the enteric microbiota. There is a symbiotic relationship between the human host and the enteric microbiota, which provides nutrition, protection against pathogenic organisms, and promotes i...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Chen WX, Ren LH, Shi RH Tags: World J Gastroenterol Source Type: research

Wireless capsule endoscopy: Perspectives beyond gastrointestinal bleeding.
Abstract Wireless capsule endoscopy (CE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal (GI) bleeding. Over subsequent years, this technology has been refined to provide superior resolution, increased battery life, and capabilities to view different parts of the GI tract. Indeed, cases for which CE proved useful have increased significantly over the last few years, with new indications for the small bowel and technical improvements that ha...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Redondo-Cerezo E, Sánchez-Capilla AD, De La Torre-Rubio P, De Teresa J Tags: World J Gastroenterol Source Type: research

Central pancreatectomy: The Dagradi Serio Iacono operation. Evolution of a surgical technique from the pioneers to the robotic approach.
Abstract Central pancreatectomy (CP) is a parenchyma-sparing surgical procedure. The aims are to clarify the history and the development of CP and to give credits to those from whom it came. Ehrhardt, in 1908, described segmental neck resection (SNR) followed, in 1910, by Finney without reconstructive part. In 1950 Honjyo described two cases of SNR combined with gastrectomy for gastric cancer infiltrating the neck of the pancreas. Guillemin and Bessot (1957) and Letton and Wilson (1959) dealt only with the reconstructive aspect of CP. Dagradi and Serio, in 1982, performed the first CP including the resective and re...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Iacono C, Ruzzenente A, Bortolasi L, Guglielmi A Tags: World J Gastroenterol Source Type: research

Recent studies of 5-fluorouracil resistance in pancreatic cancer.
Abstract Resistance to 5-fluorouracil (5-FU), an important anticancer drug, is a serious challenge in the treatment of pancreatic cancer. Equilibrative nucleoside transporter 1 and multidrug-resistance protein (MRP) 5 and MRP8, rather than P-glycoprotein, play important roles in 5-FU transport. Thymidylate synthase, dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidine phosphorylase are four key enzymes involved in 5-FU metabolism. Other metabolic enzymes, including uridine monophosphate synthetase, also contribute to chemoresistance. Intracellular signaling pathways are an integrated n...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Wang WB, Yang Y, Zhao YP, Zhang TP, Liao Q, Shu H Tags: World J Gastroenterol Source Type: research

Mechanism of gastrointestinal abnormal motor activity induced by cisplatin in conscious dogs.
CONCLUSION: After the intravenous administration of cisplatin, abnormal motor activity was produced in the involved vagus nerve and in the involved serotonergic neurons via another pathway. This study was the first to determine the relationship between 5-HT and emesis-induced motor activity. PMID: 25400453 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Ando H, Mochiki E, Ohno T, Yanai M, Toyomasu Y, Ogata K, Tabe Y, Aihara R, Nakabayashi T, Asao T, Kuwano H Tags: World J Gastroenterol Source Type: research

Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model.
CONCLUSION: The present study evidenced that CGX has hepatoprotective properties via modulation of fibrogenic cytokines and alcohol metabolism in alcoholic liver injury. PMID: 25400454 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Kim HG, Kim JM, Han JM, Lee JS, Choi MK, Lee DS, Park YH, Son CG Tags: World J Gastroenterol Source Type: research

Esophageal Helicobacter pylori colonization aggravates esophageal injury caused by reflux.
CONCLUSION: Esophageal H. pylori colonization increases esophagitis severity, and facilitates the development of BE and EAC with the augmentation of cell proliferation and apoptosis in esophageal mucosa. PMID: 25400455 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Chu YX, Wang WH, Dai Y, Teng GG, Wang SJ Tags: World J Gastroenterol Source Type: research

GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells.
CONCLUSION: The FXR agonist through regulating, at least partially, the expression of adipokines and their receptors could offer an innovative way for counteracting the progress of metabolic diseases such as nonalcoholic fatty liver disease. PMID: 25400456 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Xin XM, Zhong MX, Yang GL, Peng Y, Zhang YL, Zhu W Tags: World J Gastroenterol Source Type: research

Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model.
CONCLUSION: Caffeine reduces tumor incidence by decreasing oxidative DNA damage. CHI3L1 may contribute to CAC by increasing reactive oxygen species production. PMID: 25400457 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Ma JY, Li RH, Huang K, Tan G, Li C, Zhi FC Tags: World J Gastroenterol Source Type: research

Could JC virus provoke metastasis in colon cancer?
CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors. PMID: 25400458 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Sinagra E, Raimondo D, Gallo E, Stella M, Cottone M, Orlando A, Rossi F, Orlando E, Messina M, Tomasello G, Lo Monte AI, La Rocca E, Rizzo AG Tags: World J Gastroenterol Source Type: research

Metformin does not improve survival in patients with hepatocellular carcinoma.
CONCLUSION: Although the literature suggests a chemotherapeutic effect in other malignancies, our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. PMID: 25400459 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Bhat M, Chaiteerakij R, Harmsen WS, Schleck CD, Yang JD, Giama NH, Therneau TM, Gores GJ, Roberts LR Tags: World J Gastroenterol Source Type: research

Covert hepatic encephalopathy: Agreement and predictive validity of different indices.
CONCLUSION: CHE diagnosis probably requires a combination of clinical, neurophysiological and neuropsychological indices. PMID: 25400460 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Montagnese S, Balistreri E, Schiff S, De Rui M, Angeli P, Zanus G, Cillo U, Bombonato G, Bolognesi M, Sacerdoti D, Gatta A, Merkel C, Amodio P Tags: World J Gastroenterol Source Type: research

Reduction effect of bacterial counts by preoperative saline lavage of the stomach in performing laparoscopic and endoscopic cooperative surgery.
CONCLUSION: Pre-LECS lavage with 2000 mL of saline exhibited a bacteria-reducing effect equivalent to disinfectants and obtained favorable results in terms of clinical symptoms and data. PMID: 25400461 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Mori H, Kobara H, Tsushimi T, Fujihara S, Nishiyama N, Matsunaga T, Ayaki M, Yachida T, Tani J, Miyoshi H, Morishita A, Masaki T Tags: World J Gastroenterol Source Type: research

Magnifying endoscopy of gastric epithelial dysplasia based on the morphologic characteristics.
CONCLUSION: The MS pattern in ME-NBI findings is useful for predicting the morphologic category and mucin phenotype of GEDs, and ME-NBI findings may guide decisions regarding GED treatment. PMID: 25400462 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Kang HM, Kim GH, Park do Y, Cheong HR, Baek DH, Lee BE, Song GA Tags: World J Gastroenterol Source Type: research

Autoimmune gastritis presenting as iron deficiency anemia in childhood.
CONCLUSION: We highlight autoimmune gastritis as a diagnosis to be considered when investigating refractory iron deficiency anemia in children, particularly in the setting of a personal/familial history of autoimmune disease, as well as the diagnostic contribution of a careful immunohistological evaluation. PMID: 25400463 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Gonçalves C, Oliveira ME, Palha AM, Ferrão A, Morais A, Lopes AI Tags: World J Gastroenterol Source Type: research

Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases.
CONCLUSION: VD serum concentration correlated with health related quality of life in UC and CD patients during the winter/spring period. PMID: 25400464 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Hlavaty T, Krajcovicova A, Koller T, Toth J, Nevidanska M, Huorka M, Payer J Tags: World J Gastroenterol Source Type: research

Immediate detection of endoscopic retrograde cholangiopancreatography-related periampullary perforation: Fluoroscopy or endoscopy?
CONCLUSION: ERCP-related perforations may be difficult to diagnose by video endoscope and digital fluoroscope detection of retroperitoneal free air or contrast medium leakage can facilitate diagnosis. PMID: 25400465 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Motomura Y, Akahoshi K, Gibo J, Kanayama K, Fukuda S, Hamada S, Otsuka Y, Kubokawa M, Kajiyama K, Nakamura K Tags: World J Gastroenterol Source Type: research

Can composite performance measures predict survival of patients with colorectal cancer?
CONCLUSION: CPS values may highlight process-outcome relationships for patients with colorectal cancer in addition to evaluating quality of care performance. PMID: 25400466 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Chung KP, Chen LJ, Chang YJ, Chang YJ Tags: World J Gastroenterol Source Type: research

Healing time of incision infection after hepatobiliary surgery treated by needle-free incision suture closure.
CONCLUSION: Needle-free incision suture closure could gradually close the infection wound at the same time of drainage and dressing change, thereby shortening the healing time. PMID: 25400467 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Ma WJ, Zhou Y, Mao H, Xu RH, Shrestha A, Li FY, Lorance A, Yang Q, Zhang YQ, Jiang T, Feng H, Zhang W, Cheng NS Tags: World J Gastroenterol Source Type: research

Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation.
CONCLUSION: Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. PMID: 25400468 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: García-Albéniz X, Gallego R, Hofheinz RD, Fernández-Esparrach G, Ayuso-Colella JR, Bombí JA, Conill C, Cuatrecasas M, Delgado S, Ginés A, Miquel R, Pagés M, Pineda E, Pereira V, Sosa A, Reig O, Victoria I, Feliz L, María de Lacy A, Castells A, Burk Tags: World J Gastroenterol Source Type: research

Seroprevalence of celiac disease among United Arab Emirates healthy adult nationals: A gender disparity.
CONCLUSION: Compared to men the CD seroprevalence among women was remarkably higher. The CD association with women and chronic anemia is of importance from a public health perspective. PMID: 25400469 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Abu-Zeid YA, Jasem WS, Lebwohl B, Green PH, ElGhazali G Tags: World J Gastroenterol Source Type: research

Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea.
CONCLUSION: In contrast to a drink containing Lactobacillus casei Shirota, a commercially available probiotic drink containing Lactobacillus casei DN 114001 cost-efficiently reduces the prevalence of AAD during antibiotic treatment. PMID: 25400470 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Dietrich CG, Kottmann T, Alavi M Tags: World J Gastroenterol Source Type: research

Randomized controlled trial of sodium phosphate tablets vs polyethylene glycol solution for colonoscopy bowel cleansing.
CONCLUSION: NaP tablets, compared with PEG solution, produced equivalent colon cleansing, did not cause more side effects, and had better patient acceptability and satisfaction in the relatively young (age < 60 years) healthy individuals without comorbidity. An oral tablet formulation could make bowel preparation less burdensome, resulting in greater patient participation in screening programs. PMID: 25400471 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Jung YS, Lee CK, Kim HJ, Eun CS, Han DS, Park DI Tags: World J Gastroenterol Source Type: research

Perioperative restricted fluid therapy preserves immunological function in patients with colorectal cancer.
CONCLUSION: Perioperative restricted intravenous fluid regimen leads to a low postoperative complication rate and better cellular immunity preservation in patients with colorectal cancer. PMID: 25400472 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Jie HY, Ye JL, Zhou HH, Li YX Tags: World J Gastroenterol Source Type: research

Spontaneous and antiviral-induced cutaneous lesions in chronic hepatitis B virus infection.
CONCLUSION: Vasculitis was the most frequent spontaneous skin lesion found in chronic hepatitis B. Lichen planus was most frequent after immunization and lupus/lupus-like lesions after IFN. PMID: 25400473 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Grigorescu I, Dumitrascu DL Tags: World J Gastroenterol Source Type: research

Totally laparoscopic gastrectomy for gastric cancer: A systematic review and meta-analysis of outcomes compared with open surgery.
CONCLUSION: TLG may be a technically safe, feasible and favorable approach in terms of better cosmesis, less blood loss and faster recovery compared with OG. PMID: 25400474 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Chen K, Pan Y, Cai JQ, Xu XW, Wu D, Mou YP Tags: World J Gastroenterol Source Type: research

Dairy product consumption and gastric cancer risk: A meta-analysis.
CONCLUSION: In our meta-analysis, dairy product consumption was associated with a nonsignificantly increased risk of gastric cancer. However, this result should be verified using large, well-designed prospective studies. PMID: 25400475 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Sun Y, Lin LJ, Sang LX, Dai C, Jiang M, Zheng CQ Tags: World J Gastroenterol Source Type: research

Interleukin-17 SNPs and serum levels increase ulcerative colitis risk: A meta-analysis.
CONCLUSION: The findings strongly suggest that IL-17A/F genetic polymorphisms and serum IL-17 levels contribute to the development and progression of UC. PMID: 25400476 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Li J, Tian H, Jiang HJ, Han B Tags: World J Gastroenterol Source Type: research

Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy.
In conclusion, we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis. As the patient had other shunts, she was successfully treated by embolization of the larger shunt. PMID: 25400477 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Franzoni Lde C, de Carvalho FC, Garzon RG, Yamashiro Fda S, Augusti L, Santos LA, Dorna Mde S, Baima JP, Lima TB, Caramori CA, Silva GF, Romeiro FG Tags: World J Gastroenterol Source Type: research

Interesting rendezvous location in a liver transplantation patient with anastomosis stricture.
Abstract An endoscopic or radiologic percutaneous approach may be an initial minimally invasive method for treating biliary strictures after living donor liver transplantation; however, cannulation of biliary strictures is sometimes difficult due to the presence of a sharp or twisted angle within the stricture or a complete stricture. When an angulated or twisted biliary stricture interrupts passage of a guidewire over the stricture, it is difficult to replace the percutaneous biliary drainage catheter with inside stents by endoscopic retrograde cholangiopancreatography. The rendezvous technique can be used to over...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Odemis B, Oztas E, Yurdakul M, Torun S, Suna N, Kayacetin E Tags: World J Gastroenterol Source Type: research

Amenorrhea as a rare drug-related adverse event associated with everolimus for pancreatic neuroendocrine tumors.
Abstract The patient was an asymptomatic 43-year-old woman. Abdominal ultrasonography and enhanced computed tomography showed a tumor lesion accompanied by multiple cystic changes in the liver and the pancreatic tail. Endoscopic ultrasound-fine needle aspiration was performed on the pancreatic tumor lesion and revealed pancreatic neuroendocrine tumor (PNET). As it was unresectable due to multiple liver metastases, the decision was made to initiate treatment with everolimus and transcatheter arterial chemoembolization. The patient ceased menstruating after the start of everolimus administration. When the administrat...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Kawaguchi Y, Maruno A, Kawashima Y, Ito H, Ogawa M, Mine T Tags: World J Gastroenterol Source Type: research

Intraductal papillary neoplasm of the bile duct developing in a patient with primary sclerosing cholangitis: A case report.
We report a case of intraductal papillary neoplasm of the bile duct (IPNB) that developed in a patient with primary sclerosing cholangitis. A 46-year-old woman was admitted to our hospital with obstructive jaundice. The liver function tests demonstrated increased serum liver enzyme levels. Computed tomography showed dilatation of the intrahepatic bile ducts. Abdominal ultrasonography revealed a highly echoic protruding lesion in the posterior bile duct near the right lobe of the liver. The lesion was suspected to be IPNB, but we were unable to confirm whether it was a carcinoma. A right hepatectomy was performed, and this ...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Hachiya H, Kita J, Shiraki T, Iso Y, Shimoda M, Kubota K Tags: World J Gastroenterol Source Type: research

Delayed hypersensitivity reaction resulting in maculopapular-type eruption due to entecavir in the treatment of chronic hepatitis B.
Abstract Several clinical trials have demonstrated the potent antiviral efficacy of entecavir (ETV), and this relatively new nucleoside analogue drug has rapidly become a frequently prescribed therapy for chronic hepatitis B (CHB) worldwide. While the studies have also shown a good overall safety profile for ETV, adverse drug reactions (ADRs) in patients with advanced cirrhosis have been reported and represent a broad spectrum of drug-induced injuries, including lactic acidosis, myalgia, neuropathy, azotemia, hypophosphatemia, muscular weakness, and pancreatitis, as well as immune-mediated responses (i.e., allergic...
Source: World Journal of Gastroenterology : WJG - November 14, 2014 Category: Gastroenterology Authors: Kim JT, Jeong HW, Choi KH, Yoon TY, Sung N, Choi YK, Kim EH, Chae HB Tags: World J Gastroenterol Source Type: research