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Need of righteous attitudes towards eradication of hepatitis C virus infection in Latin America.
Abstract Over the last few years, we have expanded our knowledge on numerous facets of the hepatitis C virus (HCV). Beginning with its discovery and viral life cycle, its impact on health, the development of liver disease and currently, effective antiviral treatments. The latter point has become of great interest throughout the developed world, where the possible eradication of HCV through specific strategies to reach all HCV-infected people has been announced. However, this scenario is very different in the countries of Latin America (LA), in which < 2% of infected patients requiring treatment have access to HC...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Panduro A, Roman S Tags: World J Gastroenterol Source Type: research

Epidemiology of hepatitis E virus in Iran.
Abstract Iran is known as an endemic country for hepatitis E virus (HEV) infection, while there are variations in the epidemiology of HEV infection throughout the country. The available epidemiological studies in different regions of Iran show HEV seroprevalence of 1.1%-14.2% among general population, 4.5% -14.3% among blood donors, 6.1%-22.8% among injecting drug users, 6.3%-28.3% among hemodialysis patients, 1.6%-11.3% among patients infected with other hepatitis viruses, 27.5% among patients with chronic liver disease, 30.8% among kidney transplant recipient patients, and 10%-16.4% among human immunodeficiency v...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Taherkhani R, Farshadpour F Tags: World J Gastroenterol Source Type: research

Structural and molecular features of intestinal strictures in rats with Crohn's-like disease.
CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. PMID: 27298558 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Talapka P, Berkó A, Nagy LI, Chandrakumar L, Bagyánszki M, Puskás LG, Fekete É, Bódi N Tags: World J Gastroenterol Source Type: research

Apoptosis induced by a low-carbohydrate and high-protein diet in rat livers.
CONCLUSION: Eight weeks of an experimental diet resulted in cellular and histopathological lesions in rat livers. Apoptosis was our principal finding; elevated plasma transaminases demonstrate hepatic lesions. PMID: 27298559 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Monteiro ME, Xavier AR, Oliveira FL, Filho PJ, Azeredo VB Tags: World J Gastroenterol Source Type: research

Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-II expression on dendritic cells in chronic hepatitis C infection.
CONCLUSION: Underexpressed MHC class-II genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs. PMID: 27298560 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Tomer S, Chawla YK, Duseja A, Arora SK Tags: World J Gastroenterol Source Type: research

miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma.
CONCLUSION: The data obtained in the present study suggests that HBx enhances miR-106b transcription to promote tumor progression in HBV-associated HCC. PMID: 27298561 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Yen CS, Su ZR, Lee YP, Liu IT, Yen CJ Tags: World J Gastroenterol Source Type: research

Chitooligosaccharides promote radiosensitivity in colon cancer line SW480.
CONCLUSION: COS can inhibit the proliferation of SW480 cells and enhance the radiosensitization of SW480 cells, inducing apoptosis and G2/M phase arrest. PMID: 27298562 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Han FS, Yang SJ, Lin MB, Chen YQ, Yang P, Xu JM Tags: World J Gastroenterol Source Type: research

Faecalibacterium prausnitzii supernatant ameliorates dextran sulfate sodium induced colitis by regulating Th17 cell differentiation.
CONCLUSION: F. prausnitzii supernatant exerts protective and therapeutic effects on DSS-induced colitis in mice, probably via inhibition of Th17 differentiation and IL-17A secretion in the plasma and colon mucosa tissues. It can also improve colitis in mice by downregulating IL-6 and prevent colitis by upregulating IL-4. PMID: 27298563 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Huang XL, Zhang X, Fei XY, Chen ZG, Hao YP, Zhang S, Zhang MM, Yu YQ, Yu CG Tags: World J Gastroenterol Source Type: research

Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients.
CONCLUSION: The dysbiosis MS rat model and the post-inflammatory rat model captured some of the dysbiosis features of IBS patients. Fusobacterium, Clostridium XI and Porphyromonadaceae were identified as targets for future mechanistic research. PMID: 27298564 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zhou XY, Li M, Li X, Long X, Zuo XL, Hou XH, Cong YZ, Li YQ Tags: World J Gastroenterol Source Type: research

Factors affecting occurrence of gastric varioliform lesions: A case-control study.
CONCLUSION: Seven risk factors and two protective factors are determined for GVLs, which were found to be associated with premalignant abnormalities. PMID: 27298565 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zou TH, Zheng RH, Gao QY, Kong X, Chen XY, Ge ZZ, Chen YX, Zou XP, Fang JY Tags: World J Gastroenterol Source Type: research

Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study.
CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. PMID: 27298566 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Atsushi I, Mitsuyoshi O, Kazuya Y, Syuhei K, Noriyuki K, Masashi M, Akira W, Kentaro S, Nobuyuki K, Natsuko S, Jun W, Yasushi I, Chikara K, Itaru E Tags: World J Gastroenterol Source Type: research

Post-discharge complications after esophagectomy account for high readmission rates.
CONCLUSION: PDC after esophagectomy account for significant number of reoperations and readmissions. Efforts should be directed towards optimizing patient's health pre-discharge, with possible prevention programs at discharge. PMID: 27298567 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Chen SY, Molena D, Stem M, Mungo B, Lidor AO Tags: World J Gastroenterol Source Type: research

Clinical significance of HOTAIR expression in colon cancer.
CONCLUSION: HOTAIR expression is upregulated in colon cancer, suggesting that HOTAIR plays an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR may act as an oncogene and represents a new molecular target for the treatment of colon cancer. PMID: 27298568 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Luo ZF, Zhao D, Li XQ, Cui YX, Ma N, Lu CX, Liu MY, Zhou Y Tags: World J Gastroenterol Source Type: research

Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss.
CONCLUSION: Mirtazapine not only alleviates symptoms associated with dyspepsia and depression linked to FD in patients with weight loss but also significantly increases body weight (mainly the visceral fat in body fat). The likely mechanism of mirtazapine action is regulation of brain-gut or gastrointestinal hormone levels. PMID: 27298569 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Jiang SM, Jia L, Liu J, Shi MM, Xu MZ Tags: World J Gastroenterol Source Type: research

Inflammatory bowel disease: A descriptive study of 716 local Chilean patients.
CONCLUSION: IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries. PMID: 27298570 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Simian D, Fluxá D, Flores L, Lubascher J, Ibáñez P, Figueroa C, Kronberg U, Acuña R, Moreno M, Quera R Tags: World J Gastroenterol Source Type: research

Primary biliary cirrhosis degree assessment by acoustic radiation force impulse imaging and hepatic fibrosis indicators.
CONCLUSION: The diagnostic value of PBC cirrhosis degree in liver cirrhosis degree assessment by ARFI combined with the four indicators of serum liver fibrosis is of satisfactory effectiveness and has important clinical application value. PMID: 27298571 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zhang HC, Hu RF, Zhu T, Tong L, Zhang QQ Tags: World J Gastroenterol Source Type: research

Hepatitis C virus genotype 3: Meta-analysis on sustained virologic response rates with currently available treatment options.
CONCLUSION: Lastly, SOF + DCV combination is probably the best oral therapy option and the addition of RBV does not appear to be needed to increase SVR rates substantially. PMID: 27298572 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Ampuero J, Reddy KR, Romero-Gomez M Tags: World J Gastroenterol Source Type: research

Laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis for Peutz-Jeghers syndrome with synchronous rectal cancer.
This report presents a patient with a 20-year history of intermittent bloody stool, mucocutaneous pigmentation and a family history of PJS, which together led to a diagnosis of PJS. Moreover, colonoscopy and biopsy revealed the presence of multiple serried giant pedunculated polyps and rectal adenocarcinoma. Currently, few options exist for the therapeutic management of PJS with synchronous rectal cancer. For this case, we adopted an unconventional surgical strategy and ultimately performed laparoscopic restorative proctocolectomy with IPAA. This procedure is widely considered to be the first-line treatment option for pati...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zhong ME, Niu BZ, Ji WY, Wu B Tags: World J Gastroenterol Source Type: research

Application of cystoscope in surgical treatment of hepatocellular carcinoma with portal vein tumor thrombus.
Abstract Development of portal vein tumor thrombus deteriorates the prognosis of hepatocellular carcinoma, while surgical treatment can offer a promising prognosis for selected patients. However, the possibility of residual lesions in portal vein after conventional thrombectomy is a main risk factor leading to postoperative recurrence. Therefore, ensuring the complete removal of tumor thrombus during operation is critical to improve prognosis. For the first time, we report here one case of hepatocellular carcinoma with portal vein tumor thrombus in which cystoscope was successfully applied as a substitute of intrav...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Li N, Wei XB, Cheng SQ Tags: World J Gastroenterol Source Type: research

Surgical dilemmas in the management of colorectal liver metastases: The role of timing.
Abstract Colorectal cancer (CRC) is an emerging health problem in the Western World both for its raising tendency as well as for its metastatic potential. Almost half of the patients with CRC will develop liver metastases during the course of their disease. The liver surgeon dealing with colorectal liver metastases faces several surgical dilemmas especially in the setting of the timing of operation. Synchronous resectable metastases should be treated prior or after induction chemotherapy? Furthermore in the case of synchronous colorectal liver metastases which organ should we first deal with, the liver or the colon...
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Dimitroulis D, Kouraklis G Tags: World J Gastroenterol Source Type: research

How important is donor age in liver transplantation?
Abstract The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation (LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Li...
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Lué A, Solanas E, Baptista P, Lorente S, Araiz JJ, Garcia-Gil A, Serrano MT Tags: World J Gastroenterol Source Type: research

Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse.
Abstract External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy (VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of p...
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: van Iersel JJ, Paulides TJ, Verheijen PM, Lumley JW, Broeders IA, Consten EC Tags: World J Gastroenterol Source Type: research

Multiorgan chronic inflammatory hepatobiliary pancreatic murine model deficient in tumor necrosis factor receptors 1 and 2.
CONCLUSION: This is the first report of chronic inflammatory multiorgan hepatobiliary pancreatitis, along with fibrosis and calculi formation induced reliably utilizing oral DBTC administration in TNFR1/R2 deficient mice. PMID: 27275091 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Oz HS Tags: World J Gastroenterol Source Type: research

Phosalone-induced inflammation and oxidative stress in the colon: Evaluation and treatment.
CONCLUSION: This research highlights that EA is effective to alleviate the side effects of phosalone by reducing the level of oxidative stress and inflammatory proteins. PMID: 27275092 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Ghasemi-Niri SF, Maqbool F, Baeeri M, Gholami M, Abdollahi M Tags: World J Gastroenterol Source Type: research

CdSe/ZnS quantum dots induce photodynamic effects and cytotoxicity in pancreatic cancer cells.
CONCLUSION: CdSe/ZnS QDs can be used as a photosensitizer to inhibit SW1990 cell proliferation through ROS generation and apoptotic protein expression regulation. PMID: 27275093 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: He SJ, Cao J, Li YS, Yang JC, Zhou M, Qu CY, Zhang Y, Shen F, Chen Y, Li MM, Xu LM Tags: World J Gastroenterol Source Type: research

Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice.
CONCLUSION: Exogenous recombinant IL-22 protects mice against L-arginine-induced SAP-associated lung injury by enhancing the expression of anti-apoptosis genes through the STAT3 signaling pathway. PMID: 27275094 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Qiao YY, Liu XQ, Xu CQ, Zhang Z, Xu HW Tags: World J Gastroenterol Source Type: research

(125)I-labeled anti-bFGF monoclonal antibody inhibits growth of hepatocellular carcinoma.
CONCLUSION: (125)I-bFGF mAb inhibits growth of HCC xenografts. The coupling effect of (125)I-bFGF mAb is more effective than the concomitant use of (125)I and bFGF mAb. PMID: 27275095 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Hu PH, Pan LH, Wong PT, Chen WH, Yang YQ, Wang H, Xiang JJ, Xu M Tags: World J Gastroenterol Source Type: research

Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model.
CONCLUSION: Transarterial administration of integrin inhibitor loaded nanoparticles combined with TACE evidently retards tumor growth and intrahepatic metastases compared with TACE alone or TACE plus integrin inhibitor in an animal model of hepatocellular carcinoma. PMID: 27275096 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Qian J, Oppermann E, Tran A, Imlau U, Qian K, Vogl TJ Tags: World J Gastroenterol Source Type: research

Danish cohort of monozygotic inflammatory bowel disease twins: Clinical characteristics and inflammatory activity.
CONCLUSION: The presented IBD twin cohorts are an excellent resource for bioinformatics studies with proper adjustment for disease-associated exposures including medication and inflammatory activity in the co-twins. PMID: 27275097 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Moller FT, Knudsen L, Harbord M, Satsangi J, Gordon H, Christiansen L, Christensen K, Jess T, Andersen V Tags: World J Gastroenterol Source Type: research

Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer.
CONCLUSION: Serum KatA and AhpC antibodies are associated with GC risk and KatA may serve as a biomarker for GC. KatA/FlaA combined analysis improved screening accuracy. PMID: 27275098 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Zhang B, Li HL, Fan Q, Guo F, Ren XY, Zhou HB, Zhu JW, Zhao YS, Tian WJ Tags: World J Gastroenterol Source Type: research

Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease.
CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. PMID: 27275099 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Boucher AL, Pereira B, Decousus S, Goutte M, Goutorbe F, Dubois A, Gagniere J, Borderon C, Joubert J, Pezet D, Dapoigny M, Déchelotte PJ, Bommelaer G, Buisson A Tags: World J Gastroenterol Source Type: research

Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse.
CONCLUSION: Negative FIT results one year or more after remission induction correlate with complete mucosal healing (MES 0) and better prognosis. Performing FIT one year after remission induction may be useful for evaluating relapse risk. PMID: 27275100 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Nakarai A, Kato J, Hiraoka S, Takashima S, Takei D, Inokuchi T, Sugihara Y, Takahara M, Harada K, Okada H Tags: World J Gastroenterol Source Type: research

Blood neutrophil-lymphocyte ratio predicts survival after hepatectomy for hepatocellular carcinoma: A propensity score-based analysis.
CONCLUSION: Preoperative NLR ≥ 2.81 may be an indicator of poor DFS and OS in patients with HCC undergoing surgery. Preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS when elevated AFP levels provide no prognostic information. PMID: 27275101 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Yang HJ, Guo Z, Yang YT, Jiang JH, Qi YP, Li JJ, Li LQ, Xiang BD Tags: World J Gastroenterol Source Type: research

Serum adipokines might predict liver histology findings in non-alcoholic fatty liver disease.
CONCLUSION: Certain adipokines may determine the severity of NAFLD histology accurately. PMID: 27275102 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Jamali R, Razavizade M, Arj A, Aarabi MH Tags: World J Gastroenterol Source Type: research

Usefulness of portal vein pressure for predicting the effects of tolvaptan in cirrhotic patients.
CONCLUSION: The present study suggests that tolvaptan in the treatment of liquid retention could be more effective for patients with lower portal vein pressure. PMID: 27275103 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Nakagawa A, Atsukawa M, Tsubota A, Kondo C, Okubo T, Arai T, Itokawa N, Narahara Y, Iwakiri K Tags: World J Gastroenterol Source Type: research

Suppository naproxen reduces incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis: Randomized controlled trial.
CONCLUSION: Single dose of suppository naproxen administered immediately before ERCP reduces the incidence of PEP. PMID: 27275104 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Mansour-Ghanaei F, Joukar F, Taherzadeh Z, Sokhanvar H, Hasandokht T Tags: World J Gastroenterol Source Type: research

Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit.
CONCLUSION: Probiotic supplementation is moderately efficacious for reducing ITT in adults. Probiotics were most efficacious in constipated subjects, when evaluated in high-quality studies, and with certain probiotic strains. PMID: 27275105 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Miller LE, Zimmermann AK, Ouwehand AC Tags: World J Gastroenterol Source Type: research

Modified single transluminal gateway transcystic multiple drainage technique for a huge infected walled-off pancreatic necrosis: A case report.
We report a successful endoscopic ultrasonography-guided drainage of a huge infected multilocular walled-off necrosis (WON) that was treated by a modified single transluminal gateway transcystic multiple drainage (SGTMD) technique. After placing a wide-caliber fully covered metal stent, follow-up computed tomography revealed an undrained subcavity of WON. A large fistula that was created by the wide-caliber metal stent enabled the insertion of a forward-viewing upper endoscope directly into the main cavity, and the narrow connection route within the main cavity to the subcavity was identified with a direct view, leading to...
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Minaga K, Kitano M, Imai H, Yamao K, Kamata K, Miyata T, Matsuda T, Omoto S, Kadosaka K, Yoshikawa T, Kudo M Tags: World J Gastroenterol Source Type: research

When a liver transplant recipient goes back to alcohol abuse: Should we be more selective?
Abstract Alcoholic liver disease (ALD) is one of the most common indications for liver transplantation (LT). However, it has always remained as a complicated topic from both medical and ethical grounds, as it is seen for many a "self-inflicted disease". Over the years, the survival rate of transplanted patients has significantly improved. The allocation system and the inclusion criteria for LT has also undergone some modifications. Early LT for acute alcoholic hepatitis has been subject to recent clinical studies with encouraging results in highly selected patients. We have learned from studies the importance of a ...
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Leon M, Varon J, Surani S Tags: World J Gastroenterol Source Type: research

Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment.
Abstract In patients with inflammatory bowel disease (IBD), chronic inflammation is a major risk factor for the development of gastrointestinal malignancies. The pathogenesis of colitis-associated cancer is distinct from sporadic colorectal carcinoma and the critical molecular mechanisms underlying this process have yet to be elucidated. Patients with IBD have also been shown to be at increased risk of developing extra-intestinal malignancies. Medical therapies that diminish the mucosal inflammatory response represent the foundation of treatment in IBD, and recent evidence supports their introduction earlier in the...
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Axelrad JE, Lichtiger S, Yajnik V Tags: World J Gastroenterol Source Type: research

Hydradenitis suppurativa and inflammatory bowel disease: An unusual, but existing association.
In conclusion, an unregulated inflammation may cause the lesions typical of both HS and IBD, particularly when they coexist. However, this is still a largely unexplored field. PMID: 27239107 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Principi M, Cassano N, Contaldo A, Iannone A, Losurdo G, Barone M, Mastrolonardo M, Vena GA, Ierardi E, Di Leo A Tags: World J Gastroenterol Source Type: research

Current and emerging therapies in unresectable and recurrent gastric cancer.
Abstract Gastric cancer is one of the most lethal cancers worldwide despite many advances and options in therapy. As it is often diagnosed at an advanced stage, prognosis is poor with a median overall survival of less than twelve months. Chemotherapy remains the mainstay of treatment for these patients but it confers only a moderate survival advantage. There remains a need for new targeted treatment options and a way to better define patient populations who will benefit from these agents. In the past few years, there has been a better understanding of the biology, molecular profiling, and heterogeneity of gastric c...
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Jou E, Rajdev L Tags: World J Gastroenterol Source Type: research

Multiplex qPCR for serodetection and serotyping of hepatitis viruses: A brief review.
Abstract The present review describes the current status of multiplex quantitative real time polymerase chain reaction (qPCR) assays developed and used globally for detection and subtyping of hepatitis viruses in body fluids. Several studies have reported the use of multiplex qPCR for the detection of hepatitis viruses, including hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). In addition, multiplex qPCR has also been developed for genotyping HBV, HCV, and HEV subtypes. Although a single step multiplex qPCR assay for all six hepatitis ...
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Irshad M, Gupta P, Mankotia DS, Ansari MA Tags: World J Gastroenterol Source Type: research

Advanced imaging techniques in the therapeutic response of transarterial chemoembolization for hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization (TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resections. The evaluation of the response to TACE treatment affects not only the assessment of the therapy efficacy but also the development of the next step in the treatment plan. The use of imaging to examine changes in tumor volume to assess the response of solid tumors to treatment has been contro...
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Yang K, Zhang XM, Yang L, Xu H, Peng J Tags: World J Gastroenterol Source Type: research

Immunological changes in different patient populations with chronic hepatitis C virus infection.
CONCLUSION: Our study demonstrated a complex dysregulation of activating and inhibitory receptor expression, such as decreased NKG2D and CD160 activating receptor expression and increased KIR2DL3 inhibitory receptor expression by NK and cytotoxic T cells and may provide further mechanism contributing to defective cellular immune functions in chronic hepatitis C. Increased NKG2D receptor expression in HCV patients with persistently normal ALT suggests an important pathway for sustaining NK and CD8 T cell function and a protective role against disease progression. PMID: 27239111 [PubMed - in process] (Source: World Journ...
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Szereday L, Meggyes M, Halasz M, Szekeres-Bartho J, Par A, Par G Tags: World J Gastroenterol Source Type: research

Gastric emptying, postprandial blood pressure, glycaemia and splanchnic flow in Parkinson's disease.
CONCLUSION: In mild to moderate Parkinson's disease, gastric emptying is related to autonomic dysfunction and a determinant of the glycaemic response to oral glucose. PMID: 27239112 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Trahair LG, Kimber TE, Flabouris K, Horowitz M, Jones KL Tags: World J Gastroenterol Source Type: research

Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells.
CONCLUSION: The PI3K/AKT pathway and HIF-1α are both involved in the process of glycolysis in esophageal cancer cells. PMID: 27239113 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Zeng L, Zhou HY, Tang NN, Zhang WF, He GJ, Hao B, Feng YD, Zhu H Tags: World J Gastroenterol Source Type: research

miR-29a up-regulation in AR42J cells contributes to apoptosis via targeting TNFRSF1A gene.
CONCLUSION: miR-29a might promote the apoptosis of AR42J cells via up-regulating the expression of its target gene TNFRSF1A. PMID: 27239114 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Fu Q, Qin T, Chen L, Liu CJ, Zhang X, Wang YZ, Hu MX, Chu HY, Zhang HW Tags: World J Gastroenterol Source Type: research

Rectal cancer staging: Multidetector-row computed tomography diagnostic accuracy in assessment of mesorectal fascia invasion.
CONCLUSION: New generation CT scanner, using high resolution MPR images, represents a reliable diagnostic tool in assessment of loco-regional and whole body staging of advanced rectal cancer, especially in patients with MRI contraindications. PMID: 27239115 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Ippolito D, Drago SG, Franzesi CT, Fior D, Sironi S Tags: World J Gastroenterol Source Type: research

Clinical and ABCB11 profiles in Korean infants with progressive familial intrahepatic cholestasis.
CONCLUSION: Alterations in the transmembrane of the bile salt export pump in the Korean infants were different from those previously reported in Chinese, Japanease, Taiwanese, and European patients. PMID: 27239116 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2016 Category: Gastroenterology Authors: Park JS, Ko JS, Seo JK, Moon JS, Park SS Tags: World J Gastroenterol Source Type: research