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Gastrointestinal cancers in the era of theranostics: Updates and future perspectives.
Abstract Theranostics are one of the practical aspects of personalized medicine. This concept was designed to describe a material combining diagnosis, treatment and follow up of a disease. It evolved and included molecular targeting and nanotechnologies that incorporate both diagnosis and therapeutics. In this editorial, we are presenting briefly the concept and evolution of theranostics, highlighting many applications of theranostics in daily practice and discussing future perspectives and aspects of this model in gastro-intestincal cancers. PMID: 26229391 [PubMed - as supplied by publisher] (Source: World Jou...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Ghosn M, Kourie HR, Tabchi S Tags: World J Gastroenterol Source Type: research

Current and future treatments for hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) represents a unique challenge for physicians and patients. There is no definitively curative treatment. Rather, many treatment and management modalities exist with differing advantages and disadvantages. Both current guidelines and individual patient concerns must be taken into account in order to properly manage HCC. In addition, quality of life issues are particularly complex in patients with HCC and these concerns must also be factored into treatment strategies. Thus, considering all the options and their various pros and cons can quickly become complex for both clinicians...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Schlachterman A, Craft WW, Hilgenfeldt E, Mitra A, Cabrera R Tags: World J Gastroenterol Source Type: research

Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy.
Abstract Autophagy is a highly-regulated, conserved cellular process for the degradation of intracellular components in lysosomes to maintain the energetic balance of the cell. It is a pro-survival mechanism that plays an important role during development, differentiation, apoptosis, ageing and innate and adaptive immune response. Besides, autophagy has been described to be involved in the development of various human diseases, e.g., chronic liver diseases and the development of hepatocellular carcinoma. The hepatitis C virus (HCV) is a major cause of chronic liver diseases. It has recently been described that HCV,...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Ploen D, Hildt E Tags: World J Gastroenterol Source Type: research

Gastroesophageal reflux and congenital gastrointestinal malformations.
Abstract Although the outcome of newborns with surgical congenital diseases (e.g., diaphragmatic hernia; esophageal atresia; omphalocele; gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery, infant survivors often require intensive treatment after birth, have prolonged hospitalizations, and, after discharge, may have long-term sequelae including gastro-intestinal comorbidities, above all, gastroesophageal reflux (GER). This condition involves the involuntary retrograde passage of gastric contents into the esophagus, with or without regurgitation or vomiting. It is a well...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Marseglia L, Manti S, D'Angelo G, Gitto E, Salpietro C, Centorrino A, Scalfari G, Santoro G, Impellizzeri P, Romeo C Tags: World J Gastroenterol Source Type: research

Alcohol liver disease: A review of current therapeutic approaches to achieve long-term abstinence.
Abstract Harmful alcohol drinking may lead to significant damage on any organ or system of the body. Alcoholic liver disease (ALD) is the most prevalent cause of advanced liver disease in Europe. In ALD, only alcohol abstinence was associated with a better long-term survival. Therefore, current effective therapeutic strategy should be oriented towards achieving alcohol abstinence or a significant reduction in alcohol consumption. Screening all primary care patients to detect those cases with alcohol abuse has been proposed as population-wide preventive intervention in primary care. It has been suggested that in pat...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: García ML, Blasco-Algora S, Fernández-Rodríguez CM Tags: World J Gastroenterol Source Type: research

Circulating RNAs as new biomarkers for detecting pancreatic cancer.
Abstract Pancreatic cancer remains difficult to treat and has a high mortality rate. It is difficult to diagnose early, mainly due to the lack of screening imaging modalities and specific biomarkers. Consequently, it is important to develop biomarkers that enable the detection of early stage tumors. Emerging evidence is accumulating that tumor cells release substantial amounts of RNA into the bloodstream that strongly resist RNases in the blood and are present at sufficient levels for quantitative analyses. These circulating RNAs are upregulated in the serum and plasma of cancer patients, including those with pancr...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Takata A, Koike K Tags: World J Gastroenterol Source Type: research

Benign liver tumors in pediatric patients - Review with emphasis on imaging features.
Abstract Benign hepatic tumors are commonly observed in adults, but rarely reported in children. The reasons for this remain speculative and the exact data concerning the incidence of these lesions are lacking. Benign hepatic tumors represent a diverse group of epithelial and mesenchymal tumors. In pediatric patients, most benign focal liver lesions are inborn and may grow like the rest of the body. Knowledge of pediatric liver diseases and their imaging appearances is essential in order to make an appropriate differential diagnosis. Selection of the appropriate imaging test is challenging, since it depends on a nu...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Chiorean L, Cui XW, Tannapfel A, Franke D, Stenzel M, Kosiak W, Schreiber-Dietrich D, Jüngert J, Chang JM, Dietrich CF Tags: World J Gastroenterol Source Type: research

MicroRNA expression in hepatitis C virus-related malignancies: A brief review.
Abstract Not only is chronic hepatitis C virus (HCV) infection a major public health problem, but also it can cause hepatocellular carcinoma and, more rarely, non-Hodgkin's lymphoma. These characteristics mean that HCV is the only virus infecting humans that is able to cause two different cancers. The fine pathogenetic and molecular mechanisms by which HCV induces these two malignancies are not completely clear. In the last decade, it has been shown that microRNAs (miRNAs), a class of 21-23-nucleotide molecules modulating post-transcriptional gene expression, make an important contribution to the pathogenesis of se...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Gragnani L, Piluso A, Fognani E, Zignego AL Tags: World J Gastroenterol Source Type: research

Association of hepatocyte-derived growth factor receptor/caudal type homeobox 2 co-expression with mucosal regeneration in active ulcerative colitis.
CONCLUSION: In active UC, a portion of circulating HGFR-expressing cells are committed to the epithelial lineage, and may participate in mucosal regeneration by undergoing mesenchymal-to-epithelial transition. PMID: 26229399 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Sipos F, Constantinovits M, Valcz G, Tulassay Z, Műzes G Tags: World J Gastroenterol Source Type: research

Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice.
CONCLUSION: This novel animal model could be useful in future study of psychological stress in the pathogenesis of inflammatory bowel disease. PMID: 26229400 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Koh SJ, Kim JW, Kim BG, Lee KL, Kim JS Tags: World J Gastroenterol Source Type: research

Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinoma.
CONCLUSION: Overexpression of CCT3 in the nuclei of cancerous cells is associated with HCC progression. CCT3 may be a target that affects the activation of STAT3 in HCC. PMID: 26229401 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Cui X, Hu ZP, Li Z, Gao PJ, Zhu JY Tags: World J Gastroenterol Source Type: research

Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B.
CONCLUSION: Four linked SNPs of PNPLA3 (rs738409, rs3747206, rs4823173, and rs2072906) are correlated with susceptibility to NAFLD, NASH, liver fibrosis, and HBV dynamics in CHB patients. PMID: 26229402 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Pan Q, Zhang RN, Wang YQ, Zheng RD, Mi YQ, Liu WB, Shen F, Chen GY, Lu JF, Zhu CY, Zhang SY, Chen YM, Sun WL, Fan JG Tags: World J Gastroenterol Source Type: research

TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity.
CONCLUSION: Our results suggest that the activation of TLR4 by NCI upregulates CBS expression, which is mediated by the NF-κB signaling pathway, thus contributing to visceral hypersensitivity. PMID: 26229403 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Yuan B, Tang WH, Lu LJ, Zhou Y, Zhu HY, Zhou YL, Zhang HH, Hu CY, Xu GY Tags: World J Gastroenterol Source Type: research

Newly designed "pieced" stent in a rabbit model of benign esophageal stricture.
CONCLUSION: In this experimental protocol of benign esophageal strictures, the novel "pieced" stent demonstrated a superior removal rate with a similar migration rate compared to a conventional stent. PMID: 26229404 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Liu J, Shang L, Liu JY, Qin CY Tags: World J Gastroenterol Source Type: research

Clinical characteristics of Helicobacter pylori-negative drug-negative peptic ulcer bleeding.
CONCLUSION: Idiopathic PUB has unique clinical characteristics such as re-bleeding after initial hemostasis upon admission. Therefore, these patients need to undergo close surveillance upon admission. PMID: 26229405 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Chung WC, Jeon EJ, Kim DB, Sung HJ, Kim YJ, Lim ES, Kim MA, Oh JH Tags: World J Gastroenterol Source Type: research

Aggressive surgical resection does not improve survival in operable esophageal squamous cell carcinoma with N2-3 status.
CONCLUSION: Combined therapy has a positive role in OSCC with LN metastasis, and aggressive surgical resection does not improve survival in patients with N2-3 status. PMID: 26229406 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Zheng YZ, Zhao W, Hu Y, Ding-Lin XX, Wen J, Yang H, Liu QW, Luo KJ, Huang QY, Chen JY, Fu JH Tags: World J Gastroenterol Source Type: research

Hepatitis B surface antigen levels of cessation of nucleos(t)ide analogs associated with virological relapse in hepatitis B surface antigen-negative chronic hepatitis B patients.
CONCLUSION: We found that the virological relapse rate remained high after antiviral therapy discontinuation in the HBeAg-negative patients and that the post treatment HBsAg levels predicted virological relapse. PMID: 26229407 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Ge GH, Ye Y, Zhou XB, Chen L, He C, Wen DF, Tan YW Tags: World J Gastroenterol Source Type: research

Boceprevir early-access for advanced-fibrosis/cirrhosis in Asia-pacific hepatitis C virus genotype 1 non-responders/relapsers.
CONCLUSION: Boceprevir can be used successfully in PR treatment failures with a SVR12 > 80% if they have good on-treatment responses; however, discontinuations occurred in 30% because of virological failure or adverse events. PMID: 26229408 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Sukeepaisarnjaroen W, Pham T, Tanwandee T, Nazareth S, Galhenage S, Mollison L, Totten L, Wigg A, Altus R, Colman A, Morales B, Mason S, Jones T, Leembruggen N, Fragomelli V, Sendall C, Guan R, Sutedja D, Tan SS, Dan YY, Lee YM, Luman W, Teo EK, Than YM, Tags: World J Gastroenterol Source Type: research

Current state of laparoscopic parastomal hernia repair: A meta-analysis.
CONCLUSION: Laparoscopic intraperitoneal mesh repair is safe and effective for treating parastomal hernia. A modified Sugarbaker approach appears to provide the best outcomes. PMID: 26229409 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: DeAsis FJ, Lapin B, Gitelis ME, Ujiki MB Tags: World J Gastroenterol Source Type: research

Screening for pancreatic cancer in familial high-risk individuals: A systematic review.
CONCLUSION: Pancreatic cancer screening in familial HRIs is associated with a higher detection rate and longer survival, although screening may influence psychological function and increase the economic burden. PMID: 26229410 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Lu C, Xu CF, Wan XY, Zhu HT, Yu CH, Li YM Tags: World J Gastroenterol Source Type: research

Correlation of human epidermal growth factor receptor protein expression and colorectal cancer.
CONCLUSION: Down-regulation of HER-2 expression might be a dependable strategy for CRC therapy. PMID: 26229411 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Yang WJ, Shen XJ, Ma XX, Tan ZG, Song Y, Guo YT, Yuan M Tags: World J Gastroenterol Source Type: research

Autologous bone marrow transplantation in decompensated liver: Systematic review and meta-analysis.
CONCLUSION: Autologous bone marrow transplantation showed some benefits in patients with decompensated liver disease. However, further studies are still needed to verify its role in clinical treatment for end-stage liver disease. PMID: 26229412 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Pankaj P, Zhang Q, Bai XL, Liang TB Tags: World J Gastroenterol Source Type: research

Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn's disease.
CONCLUSION: This meta-analysis indicated that the IL-18 rs1946518 A>C, rs187238 G>C and rs360718 A>C polymorphisms may contribute to susceptibility to CD, especially among Asians and Africans. These polymorphisms are known to reduce IL-18 mRNA and protein levels. PMID: 26229413 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Gao SJ, Zhang L, Lu W, Wang L, Chen L, Zhu Z, Zhu HH Tags: World J Gastroenterol Source Type: research

Conservative reconstruction using stents as salvage therapy for disruption of esophago-gastric anastomosis.
We describe a 61-year-old man who underwent minimally invasive esophagectomy complicated by slowly progressive gastric conduit necrosis associated with complete neck drainage and a stable overall condition. There was a 2 cm gap in the anastomosis. Because there was no evidence of residual gastric conduit necrosis, a removable, covered self-expanding metal stent (SEMS) was inserted to bridge the anastomosis. The stent was fixed to the patient's ear with silk thread through the lasso on its proximal end to prevent migration. Eight weeks after insertion, the stent was removed easily without any associated complications. The a...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Oshikiri T, Yamamoto Y, Miki I, Tsuda M, Nakamura T, Fujino Y, Tominaga M, Kakeji Y Tags: World J Gastroenterol Source Type: research

Hepatic inflammatory pseudotumor presenting in an 8-year-old boy: A case report and review of literature.
Abstract Hepatic inflammatory pseudotumors are uncommon benign lesions. Accurately diagnosing hepatic inflammatory pseudotumor can be very challenging because the clinical presentation and radiological appearances are nonspecific and cannot be certainly distinguished from malignant neoplastic processes. Herein, we present a case of hepatic IPT in an 8-year-old boy who presented to clinic with a 3-mo history of a tender hepatic mass, fever of unknown origin, and 9-kg weight loss. The physical examination was notable for tender hepatomegaly. Laboratory investigations were notable for a normal hepatic profile and elev...
Source: World Journal of Gastroenterology : WJG - July 28, 2015 Category: Gastroenterology Authors: Al-Hussaini H, Azouz H, Abu-Zaid A Tags: World J Gastroenterol Source Type: research

Non-celiac gluten sensitivity: Time for sifting the grain.
Abstract In the last few years, a new nomenclature has been proposed for the disease induced by the ingestion of gluten, a protein present in wheat, rice, barley and oats. Besides celiac disease and wheat allergy, the most studied forms of gluten-related disorders characterized by an evident immune mechanism (autoimmune in celiac disease and IgE-mediated in wheat allergy), a new entity has been included, apparently not driven by an aberrant immune response: the non-celiac gluten sensitivity (NCGS). NCGS is characterized by a heterogeneous clinical picture with intestinal and extraintestinal symptoms arising after g...
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Elli L, Roncoroni L, Bardella MT Tags: World J Gastroenterol Source Type: research

Genomic medicine in gastroenterology: A new approach or a new specialty?
Abstract Throughout history, many medical milestones have been achieved to prevent and treat human diseases. Man's early conception of illness was naturally holistic or integrative. However, scientific knowledge was atomized into quantitative and qualitative research. In the field of medicine, the main trade-off was the creation of many medical specialties that commonly treat patients in advanced stages of disease. However, now that we are immersed in the post-genomic era, how should we reevaluate medicine? Genomic medicine has evoked a medical paradigm shift based on the plausibility to predict the genetic suscept...
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Roman S, Panduro A Tags: World J Gastroenterol Source Type: research

CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer.
Abstract This paper reviews the distinctive roles played by the transcriptional coactivators CREB-binding protein (CBP) and p300 in Wnt/β-catenin signaling and cell physiology in colorectal cancer (CRC). Specifically, we focus on the effects of CBP- and p300-mediated Wnt activity on (1) neoplastic progression; (2) the activities of butyrate, a breakdown product of dietary fiber, on cell signaling and colonic cell physiology; (3) the development of resistance to histone deacetylase inhibitors (HDACis), including butyrate and synthetic HDACis, in colonic cells; and (4) the physiology and number of cancer stem cells....
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Bordonaro M, Lazarova DL Tags: World J Gastroenterol Source Type: research

Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma.
Abstract Although liver resection is considered the most effective treatment for hepatocellular carcinoma (HCC), treatment outcomes are unsatisfactory because of the high rate of HCC recurrence. Since we reported hepatitis B e-antigen positivity and high serum hepatitis B virus (HBV) DNA concentrations are strong risk factors for HCC recurrence after curative resection of HBV-related HCC in the early 2000s, many investigators have demonstrated the effects of viral status on HCC recurrence and post-treatment outcomes. These findings suggest controlling viral status is important to prevent HCC recurrence and improve ...
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Kubo S, Takemura S, Tanaka S, Shinkawa H, Nishioka T, Nozawa A, Kinoshita M, Hamano G, Ito T, Urata Y Tags: World J Gastroenterol Source Type: research

Grey zone in the Barcelona Clinic Liver Cancer Classification for hepatocellular carcinoma: Surgeons' perspective.
Abstract Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most common cause of cancer-related deaths worldwide. The Barcelona Clinic Liver Cancer (BCLC) classification has been endorsed as the optimal staging system and treatment algorithm for HCC by the European Association for the Study of Liver Disease and the American Association for the Study of Liver Disease. However, in real life, the majority of patients who are not considered ideal candidates based on the BCLC guideline still were performed hepatic resection nowadays, which means many hepatic surgeons all around the world do not...
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Yang T, Lau WY, Zhang H, Huang B, Lu JH, Wu MC Tags: World J Gastroenterol Source Type: research

Clusterin: Review of research progress and looking ahead to direction in hepatocellular carcinoma.
Abstract Liver cancer, a large proportion of which is hepatocellular carcinoma (HCC), is diagnosed in more than 700000 people each year worldwide. Liver cancer is particularly prevalent in Asia, Sub-Saharan Africa and the South Pacific, where hepatitis B and hepatitis C infection rates are very high. However, due to resistance to chemotherapy, patients with intermediate and advanced-stage disease cannot benefit from this treatment. Clusterin, which is overexpressed in many different cancers, is a stress-induced cytoprotective protein that confers treatment resistance. Custirsen (OGX-011) is a novel 2'-methoxyethyl ...
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Xiu P, Dong XF, Li XP, Li J Tags: World J Gastroenterol Source Type: research

Effects of Yttrium-90 selective internal radiation therapy on non-conventional liver tumors.
Abstract The liver is a common site of metastasis, with essentially all metastatic malignancies having been known to spread to the liver. Nearly half of all patients with extrahepatic primary cancer have hepatic metastases. The severe prognostic implications of hepatic metastases have made surgical resection an important first line treatment in management. However, limitations such as the presence of extrahepatic spread or poor functional hepatic reserve exclude the majority of patients as surgical candidates, leaving chemotherapy and locoregional therapies as next best options. Selective internal radiation therapy...
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Kuei A, Saab S, Cho SK, Kee ST, Lee EW Tags: World J Gastroenterol Source Type: research

MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity.
Abstract Over the past decade, research has shown that aberrant expression of microRNA (miRNA) is involved in colorectal cancer development and progression. MicroRNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific miRNA may display the effects of a tumor suppressor or oncogene. Altered miRNA expression is found in colorectal cancer (CRC) and patterns of miRNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum miRNA and fe...
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Hollis M, Nair K, Vyas A, Chaturvedi LS, Gambhir S, Vyas D Tags: World J Gastroenterol Source Type: research

Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomes.
This article reviews the hepatitis C viral life cycle as it impacts host lipoproteins and lipid metabolism. It then describes the pathogenesis of HCV-related hepatic steatosis, hypocholesterolemia and atherosclerosis, and finally describes the promising anti-viral and anti-fibrotic effects of statins, for the treatment of CHC. PMID: 26217081 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Simon TG, Butt AA Tags: World J Gastroenterol Source Type: research

Acupuncture and regulation of gastrointestinal function.
Abstract In China, acupuncture has been considered an effective method for treating gastrointestinal (GI) dysfunction diseases for thousands of years. In fact, acupuncture has gained progressive acceptance from both practitioners and patients worldwide. However, the therapeutic effects and underlying mechanisms in treating GI dysfunction have not yet been established due to a lack of systematic and comprehensive review articles. Therefore, the aim of this review is to discuss the efficacy of acupuncture as a treatment for GI dysfunction and the associated underlying mechanisms. A search of PubMed was conducted for ...
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Li H, He T, Xu Q, Li Z, Liu Y, Li F, Yang BF, Liu CZ Tags: World J Gastroenterol Source Type: research

TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury.
CONCLUSION: HMGB1 and its downstream signaling pathway play important roles in the mouse intestinal I/R injury, and the effect of the TRIF-dependent pathway is slightly greater. PMID: 26217083 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Wang J, He GZ, Wang YK, Zhu QK, Chen W, Guo T Tags: World J Gastroenterol Source Type: research

Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation.
CONCLUSION: Givinostat has antifibrotic activities via regulating the acetylation of nuclear factor-κB and superoxide dismutase 2, thus inhibiting hepatic stellate cell proliferation and inducing apoptosis. PMID: 26217084 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Wang YG, Xu L, Wang T, Wei J, Meng WY, Wang N, Shi M Tags: World J Gastroenterol Source Type: research

Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice.
CONCLUSION: Our data demonstrated the protective effects of pretreatment with C. butyricum on anti-oxidation and anti-inflammation in different types of GU models in mice. Further studies are needed to explore its potential clinical benefits. PMID: 26217085 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Wang FY, Liu JM, Luo HH, Liu AH, Jiang Y Tags: World J Gastroenterol Source Type: research

Apoptosis of human pancreatic carcinoma cell-1 cells induced by Yin Chen Hao Decoction.
CONCLUSION: YCHD induces apoptosis of PANC-1 cells mediated in part via up-regulation of BAX and down-regulation of BCL-2. PMID: 26217086 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Zhou HB, Chen JM, Shao LM, Chen ZG Tags: World J Gastroenterol Source Type: research

Clinical features of second primary cancers arising in early gastric cancer patients after endoscopic resection.
CONCLUSION: Endoscopists should provide close surveillance and establish follow-up programs to ensure SPC detection in GC patients undergoing curative resection regardless of their clinical characteristics. PMID: 26217087 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Kim JW, Jang JY, Chang YW, Kim YH Tags: World J Gastroenterol Source Type: research

Effect of oral mesalamine on inflammatory response in acute uncomplicated diverticulitis.
CONCLUSION: Despite its limitations, this study suggests that mesalamine may allow for a faster recovery and for a reduction of inflammatory response in acute uncomplicated diverticulitis. PMID: 26217088 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Nespoli L, Lo Bianco G, Uggeri F, Romano F, Nespoli A, Bernasconi DP, Gianotti L Tags: World J Gastroenterol Source Type: research

Score model for predicting acute-on-chronic liver failure risk in chronic hepatitis B.
CONCLUSION: Using the scoring model, clinicians can easily identify patients (total score ≥ 4) at high risk of ACLF and ACLF-related death early during SAE. PMID: 26217089 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Gao FY, Liu Y, Li XS, Ye XQ, Sun L, Geng MF, Wang R, Liu HM, Zhou XB, Gu LL, Liu YM, Wan G, Wang XB Tags: World J Gastroenterol Source Type: research

Demethylation of tumor necrosis factor-α converting enzyme promoter associated with high hepatitis B e antigen level in chronic hepatitis B.
CONCLUSION: Patients with HBeAg-positive CHB have aberrant demethylation of the TACE promoter, which may potentially serve as a biomarker for HBeAg seroconversion. PMID: 26217090 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Wang ZL, Gao S, Li XY, Sun FK, Li F, Fan YC, Wang K Tags: World J Gastroenterol Source Type: research

Anatomy and influence of the splenic artery in laparoscopic spleen-preserving splenic lymphadenectomy.
CONCLUSION: It is of value for surgeons to know the splenic hilar vascular anatomy when performing LTGSPL. Patients with concentrated type SpA may be optimal patients for training new surgeons. PMID: 26217091 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Zheng CH, Xu M, Huang CM, Li P, Xie JW, Wang JB, Lin JX, Lu J, Chen QY, Cao LL, Lin M Tags: World J Gastroenterol Source Type: research

SLITRK3 expression correlation to gastrointestinal stromal tumor risk rating and prognosis.
CONCLUSION: SLITRK3 expression is a highly significant predictor of GIST recurrence and metastasis. Combinations of SLITRK3 and NIH stage have strong predictive and prognostic value, and are feasible markers for clinical practice in gastrointestinal stromal tumor. PMID: 26217092 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Wang CJ, Zhang ZZ, Xu J, Wang M, Zhao WY, Tu L, Zhuang C, Liu Q, Shen YY, Cao H, Zhang ZG Tags: World J Gastroenterol Source Type: research

Gastric mucosa in Mongolian and Japanese patients with gastric cancer and Helicobacter pylori infection.
CONCLUSION: Gastric cancer was located in the upper part of the stomach in half of the Mongolian patients; Mongolian patients were infected with non-East-Asian-type H. pylori. PMID: 26217093 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Matsuhisa T, Yamaoka Y, Uchida T, Duger D, Adiyasuren B, Khasag O, Tegshee T, Tsogt-Ochir B Tags: World J Gastroenterol Source Type: research

Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis.
CONCLUSION: Downregulation of KIF1B in HCC tissues is associated with poor prognosis; additional clinical studies are needed to confirm whether KIF1B can serve as a prognostic marker. PMID: 26217094 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Yang SZ, Wang JT, Yu WW, Liu Q, Wu YF, Chen SG Tags: World J Gastroenterol Source Type: research

Parameters affecting different acoustic radiation force impulse applications in the diagnosis of fibrotic liver changes.
CONCLUSION: Measurements in the right lobe and deep regions are preferable. Gender differences must be considered. BMI must be considered when assessing VTIQ technology. PMID: 26217095 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Galgenmueller S, Jaeger H, Kratzer W, Schmidt SA, Oeztuerk S, Haenle MM, Mason RA, Graeter T Tags: World J Gastroenterol Source Type: research

Systematic review: Eosinophilic esophagitis in Asian countries.
CONCLUSION: The characteristics of eosinophilic esophagitis in Asian patients were similar to those reported in Western patients, indicating that this disease displays a similar pathogenesis between Western and Asian patients. PMID: 26217096 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Kinoshita Y, Ishimura N, Oshima N, Ishihara S Tags: World J Gastroenterol Source Type: research

Outcomes of robotic vs laparoscopic hepatectomy: A systematic review and meta-analysis.
CONCLUSION: Laparoscopic liver resection resulted in reduced blood loss and shorter surgical times compared to robotic liver resections. There was no difference in conversion rate, R1 resection rate, morbidity and length of postoperative stay. PMID: 26217097 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 21, 2015 Category: Gastroenterology Authors: Montalti R, Berardi G, Patriti A, Vivarelli M, Troisi RI Tags: World J Gastroenterol Source Type: research