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Histological mixed-type as an independent prognostic factor in stage I gastric carcinoma.
CONCLUSION: Histological mixed-type of gastric cancer contributes to malignant outcomes and highlight its usefulness as a prognostic indicator in stage I gastric cancer. PMID: 25593472 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 14, 2015 Category: Gastroenterology Authors: Komatsu S, Ichikawa D, Miyamae M, Shimizu H, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Kishimoto M, Otsuji E Tags: World J Gastroenterol Source Type: research

Surgery for obstructed defecation syndrome-is there an ideal technique.
Abstract Obstructive defecation syndrome (ODS) is a common disorder with a considerable impact on the quality of life of affected patients. Surgery for ODS remains a challenging topic. There exists a great variety of operative techniques to treat patients with ODS. According to the surgeon's preference the approach can be transanal, transvaginal, transperineal or transabdominal. All techniques have its advantages and disadvantages. Notably, high evidence based studies are significantly lacking in literature, thus making accurate assessments difficult. Careful patient's selection is crucial to achieve optimal functi...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Riss S, Stift A Tags: World J Gastroenterol Source Type: research

Fecal transplant policy and legislation.
Abstract Fecal microbiota transplantation (FMT) has garnered significant attention in recent years in the face of a reemerging Clostridium difficile (C. difficile) epidemic. Positive results from the first randomized control trial evaluating FMT have encouraged the medical community to explore the process further and expand its application beyond C. difficile infections and even the gastrointestinal domain. However promising and numerous the prospects of FMT appear, the method remains limited in scope today due to several important barriers, most notably a poorly defined federal regulatory policy. The Food and Drug...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Vyas D, Aekka A, Vyas A Tags: World J Gastroenterol Source Type: research

Modern management of anal fistula.
Abstract Ideal surgical treatment for anal fistula should aim to eradicate sepsis and promote healing of the tract, whilst preserving the sphincters and the mechanism of continence. For the simple and most distal fistulae, conventional surgical options such as laying open of the fistula tract seem to be relatively safe and therefore, well accepted in clinical practise. However, for the more complex fistulae where a significant proportion of the anal sphincter is involved, great concern remains about damaging the sphincter and subsequent poor functional outcome, which is quite inevitable following conventional surgi...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Limura E, Giordano P Tags: World J Gastroenterol Source Type: research

Differential diagnosis in inflammatory bowel disease colitis: State of the art and future perspectives.
Abstract Distinction between Crohn's disease of the colon-rectum and ulcerative colitis or inflammatory bowel disease (IBD) type unclassified can be of pivotal importance for a tailored clinical management, as each entity often involves specific therapeutic strategies and prognosis. Nonetheless, no gold standard is available and the uncertainty of diagnosis may frequently lead to misclassification or repeated examinations. Hence, we have performed a literature search to address the problem of differential diagnosis in IBD colitis, revised current and emerging diagnostic tools and refined disease classification stra...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Tontini GE, Vecchi M, Pastorelli L, Neurath MF, Neumann H Tags: World J Gastroenterol Source Type: research

Systematic mechanism-orientated approach to chronic pancreatitis pain.
Abstract Pain in chronic pancreatitis (CP) shows similarities with other visceral pain syndromes (i.e., inflammatory bowel disease and esophagitis), which should thus be managed in a similar fashion. Typical causes of CP pain include increased intrapancreatic pressure, pancreatic inflammation and pancreatic/extrapancreatic complications. Unfortunately, CP pain continues to be a major clinical challenge. It is recognized that ongoing pain may induce altered central pain processing, e.g., central sensitization or pro-nociceptive pain modulation. When this is present conventional pain treatment targeting the nocicepti...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Bouwense SA, de Vries M, Schreuder LT, Olesen SS, Frøkjær JB, Drewes AM, van Goor H, Wilder-Smith OH Tags: World J Gastroenterol Source Type: research

Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics.
Abstract Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology characterized by hypergammaglobulinemia, autoantibodies detection and interface hepatitis. Due to the absence of specific diagnostic markers and the large heterogeneity of its clinical, laboratory and histological features, AIH diagnosis may be potentially difficult. Therefore, in this in-depth review we summarize the substantial progress on etiopathogenesis, clinical, serological and histological phenotypes of AIH. AIH has a global distribution affecting any age, both sexes and all ethnic groups. Clinical manifestat...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Gatselis NK, Zachou K, Koukoulis GK, Dalekos GN Tags: World J Gastroenterol Source Type: research

p53 mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation.
Abstract Colorectal cancer (CRC) is one of the most common malignancies with high prevalence and low 5-year survival. CRC is a heterogeneous disease with a complex, genetic and biochemical background. It is now generally accepted that a few important intracellular signaling pathways, including Wnt/β-catenin signaling, Ras signaling, and p53 signaling are frequently dysregulated in CRC. Patients with mutant p53 gene are often resistant to current therapies, conferring poor prognosis. Tumor suppressor p53 protein is a transcription factor inducing cell cycle arrest, senescence, and apoptosis under cellular stress. E...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Li XL, Zhou J, Chen ZR, Chng WJ Tags: World J Gastroenterol Source Type: research

Radiation therapy has been shown to be adaptable for various stages of hepatocellular carcinoma.
Abstract In addition to surgical procedures, radiofrequency ablation is commonly used for the treatment of hepatocellular carcinomas (HCCs) of limited size and number. Transcatheter arterial chemoembolization (TACE), using iodized poppy seed oil, Lipiodol and anticancer drugs, has been actively performed for the treatment of unresectable HCC, particularly in Asian countries. Recently, Sorafenib become available for advanced HCCs when the liver is still sufficiently functional. Sorafenib is an oral multikinase inhibitor with antiproliferative and antiangiogenic effects. However, the effect of sorafenib seems to be i...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Kondo Y, Kimura O, Shimosegawa T Tags: World J Gastroenterol Source Type: research

Fecal microbiota transplantation broadening its application beyond intestinal disorders.
Abstract Intestinal dysbiosis is now known to be a complication in a myriad of diseases. Fecal microbiota transplantation (FMT), as a microbiota-target therapy, is arguably very effective for curing Clostridium difficile infection and has good outcomes in other intestinal diseases. New insights have raised an interest in FMT for the management of extra-intestinal disorders associated with gut microbiota. This review shows that it is an exciting time in the burgeoning science of FMT application in previously unexpected areas, including metabolic diseases, neuropsychiatric disorders, autoimmune diseases, allergic dis...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Xu MQ, Cao HL, Wang WQ, Wang S, Cao XC, Yan F, Wang BM Tags: World J Gastroenterol Source Type: research

Stem cells in gastric cancer.
Abstract Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide. Cancer stem cells (CSCs), which were first identified in acute myeloid leukemia and subsequently in a large array of solid tumors, play important roles in cancer initiation, dissemination and recurrence. CSCs are often transformed tissue-specific stem cells or de-differentiated transit amplifying progenitor cells. Several populations of multipotent gastric stem cells (GSCs) that reside in the stomach have been determined to regulate physiological tissue renewal and injury repair. These populations include the Villin+ an...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Zhao Y, Feng F, Zhou YN Tags: World J Gastroenterol Source Type: research

Review of the treatment of liver hydatid cysts.
Abstract A review was carried out in Medline, LILACS and the Cochrane Library. Our database search strategy included the following terms: "hydatid cyst", "liver", "management", "meta-analysis" and "randomized controlled trial". No language limits were used in the literature search. The latest electronic search date was the 7(th) of January 2014. Inclusion and exclusion criteria: all relevant studies on the assessment of therapeutic methods for hydatid cysts of the liver were considered for analysis. Information from editorials, letters to publishers, low quality review articles and studies done on animals were excl...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Gomez I Gavara C, López-Andújar R, Belda Ibáñez T, Ramia Ángel JM, Moya Herraiz Á, Orbis Castellanos F, Pareja Ibars E, San Juan Rodríguez F Tags: World J Gastroenterol Source Type: research

Extent of surgery in cancer of the colon: Is more better?
Abstract Since the introduction of total mesorectal excision as the standard approach in mid and low rectal cancer, the incidence of local recurrence has sharply declined. Similar attention to surgical technique in colon cancer (CC) has resulted in the concept of complete mesocolic excision (CME), which consists of complete removal of the intact mesentery and high ligation of the vascular supply at its origin. Although renewed attention to meticulous surgical technique certainly has its merits, routine implementation of CME is currently unfounded. Firstly, in contrast to rectal cancer, local recurrence originating ...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Willaert W, Ceelen W Tags: World J Gastroenterol Source Type: research

Pharmacological therapy used in the elimination of Helicobacter pylori infection: A review.
Abstract The optimal therapy for Helicobacter pylori (H. pylori) infection should combine a high cure rate and a short treatment duration with a favorable side-effect profile and should maintain a low cost. Several strategies have been proposed to increase the H. pylori eradication rate, including the extension of the treatment duration to 14 d, the use of a four-drug regimen (quadruple, sequential, and concomitant treatments), and the use of novel antibiotics, such as levofloxacin. However, triple therapy remains the most widely accepted first-line treatment regimen in Brazil and the United States and throughout E...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Dos Santos AA, Carvalho AA Tags: World J Gastroenterol Source Type: research

Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis.
CONCLUSION: Alterations in VIP expression may play a role in IBS. Therefore, a better understanding of the physiology of VIP could lead to new therapeutics. PMID: 25574088 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Del Valle-Pinero AY, Sherwin LB, Anderson EM, Caudle RM, Henderson WA Tags: World J Gastroenterol Source Type: research

Establishment and characterization of cell lines from chromosomal instable colorectal cancer.
CONCLUSION: We successfully established and characterized novel ultra-low passage patient-derived CRC models as useful instruments for analyzing biological characteristics associated with the CIN(+) phenotype. PMID: 25574089 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Maletzki C, Gock M, Randow M, Klar E, Huehns M, Prall F, Linnebacher M Tags: World J Gastroenterol Source Type: research

Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine.
CONCLUSION: A diet rich in SFA and omega-3 PUFA exacerbated NSAID-induced small intestinal damage via increased leukocyte infiltration. Importantly, a diet rich in omega-6-PUFA did not aggravate inflammation as monocyte migration was blocked. PMID: 25574090 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Ueda T, Hokari R, Higashiyama M, Yasutake Y, Maruta K, Kurihara C, Tomita K, Komoto S, Okada Y, Watanabe C, Usui S, Nagao S, Miura S Tags: World J Gastroenterol Source Type: research

Enterocyte dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin expression in inflammatory bowel disease.
CONCLUSION: IECs regulate tissue-associated immune compartments under the control of DC-SIGN in IBD. PMID: 25574091 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Zeng JQ, Xu CD, Zhou T, Wu J, Lin K, Liu W, Wang XQ Tags: World J Gastroenterol Source Type: research

FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma.
CONCLUSION: FoxM1 overexpression promotes EMT and metastasis of HCC, and SNAI1 plays a critical role in FoxM1-mediated EMT. PMID: 25574092 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Meng FD, Wei JC, Qu K, Wang ZX, Wu QF, Tai MH, Liu HC, Zhang RY, Liu C Tags: World J Gastroenterol Source Type: research

Monochromatic energy computed tomography image for active intestinal hemorrhage: A model investigation.
CONCLUSION: Monochromatic energy imaging spectral CT is superior to polychromatic energy images for the detection of intestinal hemorrhage, and the detection was easier in the PVP compared with the AP. PMID: 25574093 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Liu WD, Wu XW, Hu JM, Wang B, Liu B Tags: World J Gastroenterol Source Type: research

Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease.
CONCLUSION: These findings propose FSPs as potential novel class of inflammation-associated antigens and this in turn may have implications for screening, diagnosis as well as clinical management of patients suffering from IBD and other inflammatory conditions. PMID: 25574094 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Kuehn F, Klar E, Bliemeister A, Linnebacher M Tags: World J Gastroenterol Source Type: research

Frequency and associated factors of hair loss among patients with inflammatory bowel disease.
CONCLUSION: Hair loss is common among patients with IBD. Mesalamine and anti-TNF medications were associated with lower odds of hair loss. Further studies are required to assess the mechanism of hair loss among patients with IBD. PMID: 25574095 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Shah R, Abraham B, Hou J, Sellin J Tags: World J Gastroenterol Source Type: research

Interferon therapy in hepatitis C leading to chronic type 1 diabetes.
CONCLUSION: INF-associated T1DM in HCV has a fulminant course, often associated with other autoimmune diseases, and results almost inevitably in permanent insulin therapy requirement. PMID: 25574096 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Zornitzki T, Malnick S, Lysyy L, Knobler H Tags: World J Gastroenterol Source Type: research

Helicobacter pylori infection in patients with selective immunoglobulin E deficiency.
CONCLUSION: IgEd is associated with higher rates of H. pylori-associated gastritis and peptic duodenal ulcers. PMID: 25574097 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Magen E, Schlesinger M, Ben-Zion I, Vardy D Tags: World J Gastroenterol Source Type: research

Post-hepatectomy survival in advanced hepatocellular carcinoma with portal vein tumor thrombosis.
CONCLUSION: Hepatectomy for vp3-4 HCC results in a survival rate similar to hepatectomy for vp1-2. AFP stratified the stage II-III HCC patients according to prognosis. PMID: 25574098 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Yamamoto Y, Ikoma H, Morimura R, Shoda K, Konishi H, Murayama Y, Komatsu S, Shiozaki A, Kuriu Y, Kubota T, Nakanishi M, Ichikawa D, Fujiwara H, Okamoto K, Sakakura C, Ochiai T, Otsuji E Tags: World J Gastroenterol Source Type: research

Azathioprine is essential following cyclosporine for patients with steroid-refractory ulcerative colitis.
CONCLUSION: Maintenance therapy with azathioprine might improve the long-term efficacy of continuously infused cyclosporine for severe steroid-refractory ulcerative colitis patients. PMID: 25574099 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Miyake N, Ando T, Ishiguro K, Maeda O, Watanabe O, Hirayama Y, Maeda K, Morise K, Matsushita M, Furukawa K, Funasaka K, Nakamura M, Miyahara R, Ohmiya N, Goto H Tags: World J Gastroenterol Source Type: research

Long-term survival after resection of pancreatic cancer: A single-center retrospective analysis.
CONCLUSION: Negative surgical margins and a tumor size ≤ 20 mm were independent favorable prognostic factors. Histologically curative resection and early tumor detection are important factors in achieving long-term survival. PMID: 25574100 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Yamamoto T, Yagi S, Kinoshita H, Sakamoto Y, Okada K, Uryuhara K, Morimoto T, Kaihara S, Hosotani R Tags: World J Gastroenterol Source Type: research

Clinical outcomes of small cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder.
CONCLUSION: The strategy for treating patients with GB-NEC-SCC should be similar to that used for treating GB-adenocarcinoma, including radical cholecystectomy and liver resection. PMID: 25574101 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Yun SP, Shin N, Seo HI Tags: World J Gastroenterol Source Type: research

Morphologic factors of biliary trees are associated with gallstone-related biliary events.
CONCLUSION: These findings will help guide the treatment of patients with asymptomatic gallstones. Clinicians should closely monitor patients with asymptomatic gallstones who exhibit these characteristics. PMID: 25574102 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Park JS, Lee DH, Lim JH, Jeong S, Jeon YS Tags: World J Gastroenterol Source Type: research

Autoantibodies in Chinese patients with chronic hepatitis B: Prevalence and clinical associations.
CONCLUSION: ANA-H could be an indicator of early-stage CHB. Dichotomizing the autoantibody profiles revealed that the PBC profile is strongly associated with cirrhosis in CHB. PMID: 25574103 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Li BA, Liu J, Hou J, Tang J, Zhang J, Xu J, Song YJ, Liu AX, Zhao J, Guo JX, Chen L, Wang H, Yang LH, Lu J, Mao YL Tags: World J Gastroenterol Source Type: research

Latent structure of irritable bowel syndrome symptom severity.
CONCLUSION: The findings suggest that IBS symptom severity might best be understood as a continuous and multidimensional construct which can be reliably and validly assessed with the B-IBS. PMID: 25574104 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Jasper F, Egloff B, Roalfe A, Witthöft M Tags: World J Gastroenterol Source Type: research

Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease.
CONCLUSION: Liver steatosis reduction is associated with changes in fatty acid profiles, and these changes may reflect an alteration in fatty acid synthesis and metabolism. These findings may help better understand regression of nonalcoholic fatty liver disease. PMID: 25574105 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Maciejewska D, Drozd A, Ossowski P, Ryterska K, Jamioł-Milc D, Banaszczak M, Raszeja-Wyszomirska J, Kaczorowska M, Sabinicz A, Stachowska E Tags: World J Gastroenterol Source Type: research

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations.
CONCLUSION: TERT promoter is one of most frequent mutational targets in liver cancer, and hepatocellular carcinogenesis is highly associated with the loss of telomere-dependent cellular senescence control. PMID: 25574106 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Cevik D, Yildiz G, Ozturk M Tags: World J Gastroenterol Source Type: research

Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis.
CONCLUSION: CF patients with DIOS suffer from recurrent hospitalizations and airway pathogen acquisition. Although recurrence of DIOS is common, conservative treatment is successful in most patients. PMID: 25574107 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Lavie M, Manovitz T, Vilozni D, Levy-Mendelovich S, Sarouk I, Weintraubv I, Shoseyov D, Cohen-Cymberknoh M, Rivlin J, Efrati O Tags: World J Gastroenterol Source Type: research

Impact of fecal occult blood on obscure gastrointestinal bleeding: Observational study.
CONCLUSION: The present study suggests that positive FOBT may be useful for predicting SBDs in patients with occult OGIB. Positive FOBT indicates higher likelihood of ulcers or tumors in patients with occult OGIB. Undergoing CE within a day after FOBT achieved a higher diagnostic yield for patients with occult OGIB. PMID: 25574108 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Kobayashi Y, Watabe H, Yamada A, Suzuki H, Hirata Y, Yamaji Y, Yoshida H, Koike K Tags: World J Gastroenterol Source Type: research

Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker.
CONCLUSION: Levels of circulating MACC1 transcripts in plasma of gastric cancer patients are of diagnostic value and are prognostic for patient survival in a prospective study. PMID: 25574109 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke KD, Stein U Tags: World J Gastroenterol Source Type: research

Human Papillomavirus does not have a causal role in colorectal carcinogenesis.
CONCLUSION: Based on our results, HPV is unlikely involved in colorectal carcinogenesis. PMID: 25574110 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Lorenzon L, Mazzetta F, Pilozzi E, Uggeri G, Torrisi MR, Ferri M, Ziparo V, French D Tags: World J Gastroenterol Source Type: research

Concomitant therapy achieved the best eradication rate for Helicobacter pylori among various treatment strategies.
CONCLUSION: The eradication rate for the concomitant therapy was much higher than those of the standard triple therapy or sequential therapy (ClinicalTrials.gov number NCT01922765). PMID: 25574111 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Lee HJ, Kim JI, Lee JS, Jun EJ, Oh JH, Cheung DY, Chung WC, Kim BW, Kim SS Tags: World J Gastroenterol Source Type: research

Giant colonic diverticulum: Clinical presentation, diagnosis and treatment: Systematic review of 166 cases.
CONCLUSION: Giant colonic diverticulum is a rare manifestation of diverticular diseases. Surgical treatment, consisting predominantly of colonic resection with en bloc resection of the diverticulum, is the preferred option for GCD and guarantees excellent results. PMID: 25574112 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Nigri G, Petrucciani N, Giannini G, Aurello P, Magistri P, Gasparrini M, Ramacciato G Tags: World J Gastroenterol Source Type: research

Indocyanine green fluorescence and three-dimensional imaging of right gastroepiploic artery in gastric tube cancer.
Abstract A 79-year-old male was admitted to our hospital for the treatment of cancer of the gastric tube. Gastrointestinal examination revealed a T1b Union for International Cancer Control (UICC) tumor at the pyloric region of the gastric tube. Laparotomy did not reveal infiltration into the serosa, peritoneal dissemination, regional lymph node swelling, or distant metastasis. We performed a distal gastrectomy preserving the right gastroepiploic artery by referencing the preoperative three-dimensional computed tomoangiography. We also evaluated the blood flow of the right gastroepiploic artery and in the proximal g...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Nakano T, Sakurai T, Maruyama S, Ozawa Y, Kamei T, Miyata G, Ohuchi N Tags: World J Gastroenterol Source Type: research

Placement of (125)I seed strands and stents for a type IV Klatskin tumor.
Abstract Herein, we report a new technique that consists of placing two (125)I seed strands and two stents in the right and left intrahepatic bile ducts for the treatment of hilar cholangiocarcinoma. A 75-year-old man presented with jaundice and was diagnosed with Bismuth type IV Klatskin tumor. Abdominal computed tomography (CT) showed intrahepatic and extrahepatic bile duct dilatation and a soft tissue mass in the hepatic hilum. Because curative surgical resection was not possible, we placed (125)I seed strands and stents in the right and left intrahepatic bile ducts. Three months later, abdominal CT showed less ...
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Zhang W, Yang ZQ, Shi HB, Liu S, Zhou WZ, Zhao LB Tags: World J Gastroenterol Source Type: research

Re: ''Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis: Systematic review and meta-analysis''.
Abstract Twaij and colleagues have carried out a meta-analysis of cohort studies to review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma in patients with known liver cirrhosis. We congratulate and applaud their important work, but several important issues should be noted. PMID: 25574115 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2015 Category: Gastroenterology Authors: Li ZZ, Chen LZ Tags: World J Gastroenterol Source Type: research

Pushing the frontiers of living donor right hepatectomy.
Abstract Living donor right hepatectomy (LDRH) is currently the most common donor surgery in adult-to-adult living donor liver transplantation although the morbidity and mortality reported in living donors still contradicts the Hippocratic tenet of "do no harm". Achieving low complication rates in LDRH remains a matter of major concern. Living donor surgery is performed worldwide as an established solution to the donor shortage. The aim of this study was to assess the current status of LDRH and comment on the future of the procedure; assessment was made from the standpoint of optimizing the donor selection criteria...
Source: World Journal of Gastroenterology : WJG - December 28, 2014 Category: Gastroenterology Authors: Kim SH, Lee SD, Kim YK, Park SJ Tags: World J Gastroenterol Source Type: research

Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic steatosis. The pathogenesis of NAFLD and nonalcoholic steatohepatitis (NASH) has not been fully elucidated. The "two-hit" hypothesis is probably a too simplified model to elaborate complex pathogenetic events occurring in patients with NASH. It should be better regarded as a multiple step process, with accumulation of liver fat being the first step, followed by the development of necroinflammation and fibrosis. Adipose tissu...
Source: World Journal of Gastroenterology : WJG - December 28, 2014 Category: Gastroenterology Authors: Stojsavljević S, Gomerčić Palčić M, Virović Jukić L, Smirčić Duvnjak L, Duvnjak M Tags: World J Gastroenterol Source Type: research

Fluid resuscitation in acute pancreatitis.
Abstract Acute pancreatitis remains a clinical challenge, despite an exponential increase in our knowledge of its complex pathophysiological changes. Early fluid therapy is the cornerstone of treatment and is universally recommended; however, there is a lack of consensus regarding the type, rate, amount and end points of fluid replacement. Further confusion is added with the newer studies reporting better results with controlled fluid therapy. This review focuses on the pathophysiology of fluid depletion in acute pancreatitis, as well as the rationale for fluid replacement, the type, optimal amount, rate of infusio...
Source: World Journal of Gastroenterology : WJG - December 28, 2014 Category: Gastroenterology Authors: Aggarwal A, Manrai M, Kochhar R Tags: World J Gastroenterol Source Type: research

New trends in colorectal surgery: Single port and natural orifice techniques.
Abstract Single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) have rapidly gained pace worldwide, potentially replacing conventional laparoscopic surgery (CLS) as the preferred colorectal surgery technique. Currently available data mainly consist of retrospective series analyzed in four meta-analyses. Despite conflicting results and lack of an objective comparison, SILS appears to offer cosmetic advantages over CLS. However, due to conflicting results and marked heterogeneity, present data fail to show significant differences in terms of operative time, postoperati...
Source: World Journal of Gastroenterology : WJG - December 28, 2014 Category: Gastroenterology Authors: Daher R, Chouillard E, Panis Y Tags: World J Gastroenterol Source Type: research

Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes.
Abstract Patients with inflammatory bowel disease (IBD) have an increased risk of 10%-15% developing colorectal cancer (CRC) that is a common disease of high economic costs in developed countries. The CRC has been increasing in recent years and its mortality rates are very high. Multiple biological and biochemical factors are responsible for the onset and progression of this pathology. Moreover, it appears absolutely necessary to investigate the environmental factors favoring the onset of CRC and the promotion of colonic health. The gut microflora, or microbiota, has an extensive diversity both quantitatively and q...
Source: World Journal of Gastroenterology : WJG - December 28, 2014 Category: Gastroenterology Authors: Tomasello G, Tralongo P, Damiani P, Sinagra E, Di Trapani B, Zeenny MN, Hajj Hussein I, Jurjus A, Leone A Tags: World J Gastroenterol Source Type: research

Non invasive tools for the diagnosis of liver cirrhosis.
Abstract Liver cirrhosis (LC), the end stage of many forms of chronic hepatitis of different etiologies is a diffuse process characterized by fibrosis and the conversion of normal liver architecture into structurally abnormal nodules surrounded by annular fibrosis. This chronic progressive clinical condition, leads to liver cell failure and portal hypertension, which can favour the onset of hepatocellular carcinoma. Defining the phase of the natural history is crucial for therapeutic choice and prognosis. Liver biopsy is currently considered the best available standard of reference but it has some limits, so altern...
Source: World Journal of Gastroenterology : WJG - December 28, 2014 Category: Gastroenterology Authors: Soresi M, Giannitrapani L, Cervello M, Licata A, Montalto G Tags: World J Gastroenterol Source Type: research

Colorectal carcinogenesis-update and perspectives.
Abstract Colorectal cancer (CRC) is a very common malignancy in the Western World and despite advances in surgery, chemotherapy and screening, it is still the second leading cause of cancer deaths in this part of the world. Numerous factors are found important in the development of CRC including colonocyte metbolism, high risk luminal environment, inflammation, as well as lifestyle factors such as diet, tobacco, and alchohol consumption. In recent years focus has turned towards the genetics and molecular biology of CRC and several interesting and promising correlations and pathways have been discovered. The major g...
Source: World Journal of Gastroenterology : WJG - December 28, 2014 Category: Gastroenterology Authors: Raskov H, Pommergaard H, Burcharth J, Rosenberg J Tags: World J Gastroenterol Source Type: research

Effect of laparoscopic abdominal surgery on splanchnic circulation: Historical developments.
Abstract With the developments in medical technology and increased surgical experience, advanced laparoscopic surgical procedures are performed successfully. Laparoscopic abdominal surgery is one of the best examples of advanced laparoscopic surgery (LS). Today, laparoscopic abdominal surgery in general surgery clinics is the basis of all abdominal surgical interventions. Laparoscopic abdominal surgery is associated with systemic and splanchnic hemodynamic alterations. Inadequate splanchnic perfusion in critically ill patients is associated with increased morbidity and mortality. The underlying pathophysiological m...
Source: World Journal of Gastroenterology : WJG - December 28, 2014 Category: Gastroenterology Authors: Hatipoglu S, Akbulut S, Hatipoglu F, Abdullayev R Tags: World J Gastroenterol Source Type: research