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Effects of manufacturing conditions on pharmaceutical properties of petrolatum ointment.
In this study, it was clear that the pharmaceutical properties of WP ointment samples were particularly influenced by the paddle-mixer stopping temperature. PMID: 27193304 [PubMed - as supplied by publisher] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 19, 2016 Category: Drugs & Pharmacology Authors: Ashizuka Y, Horisawa E Tags: Yakugaku Zasshi Source Type: research

Inspired Visions of Young Pharmacologists; from Bench to Bedside.
PMID: 27150919 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Sato H, Kurauchi Y Tags: Yakugaku Zasshi Source Type: research

Possible Involvement of Insulin Resistance in the Progression of Cancer Cachexia in Mice.
Abstract Malnutrition is a common problem among cancer patients, affecting up to 85% of patients with certain cancers. In severe cases, malnutrition can progress to cachexia, a specific form of malnutrition characterized by loss of lean body mass and muscle wasting. Although this muscle wasting might be a product of enhanced protein degradation, the precise mechanisms of cancer cachexia are not fully elucidated. Based on basic and clinical research, glucose intolerance and insulin resistance have been postulated to be associated with cancer cachexia. Since insulin in the skeletal muscle inhibits protein degradation...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Ohsawa M, Murakami T, Kume K Tags: Yakugaku Zasshi Source Type: research

Functional Relationship between Arterial Tissue and Perivascular Adipose Tissue in Metabolic Syndrome.
Abstract Metabolic syndrome is a complex of disorders that includes visceral obesity, insulin resistance, hypertension, and dyslipidemia. It is characterized by an increased risk for serious cardiovascular events. Adipocytes are now recognized to contribute to the development of cardiovascular complications in metabolic syndrome via the release of several bioactive substances (adipocytokines). Obesity induces an increase in the volume of perivascular adipose tissue (PVAT), which is located outside the blood vessels. In recent years, PVAT has been reported to produce/release vasoactive adipocytokines. Thus, PVAT can...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Kagota S, Iwata S, Maruyama K, Wakuda H, Shinozuka K Tags: Yakugaku Zasshi Source Type: research

Molecular Understanding of the Acquisition of Resistance to Anti-cancer Drugs Associated with the Exacerbation of Cancer.
Abstract Gefitinib and erlotinib target the ATP cleft in the tyrosine kinase EGFR, which is overexpressed in 40-80 percent of non-small-cell lung cancer (NSCLC) and many other epithelial cancers. However, the application of gefitinib is ultimately limited by the emergence of mutations and other molecular mechanisms conferring drug resistance. Furthermore, it has been considered that acquired resistance to gefitinib is associated with a clinically significant risk of accelerated disease progression. We previously established a new gefitinib-resistant NSCLC cell line, HCC827GR, which harbors the T790M mutation. Using...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Kuzumaki N, Narita M, Ikegami D, Narita M Tags: Yakugaku Zasshi Source Type: research

Gene-manipulated Adipocytes for the Treatment of Various Intractable Diseases.
Abstract Although protein replacement is an effective treatment for serum protein deficiencies such as diabetes and hemophilia, recombinant protein products are not available for all rare inherited diseases due to the instability of the recombinant proteins and/or to cost. Gene therapy is the most attractive option for treating patients with such rare diseases. To develop an effective ex vivo gene therapy-based protein replacement treatment requires recipient cells that differ from those used in standard gene therapy, which is performed to correct the function of the recipient cells. Adipose tissue is an expected s...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Kuroda M, Bujo H, Aso M, Saito Y, Yokote K Tags: Yakugaku Zasshi Source Type: research

Preliminary Evidence for Impaired Brain Activity of Neural Reward Processing in Children and Adolescents with Reactive Attachment Disorder.
Abstract Childhood maltreatment, which markedly increases risks for psychopathology, is associated with structural and functional brain differences. Especially, exposure to parental verbal abuse (PVA) or interparental violence during childhood is associated with negative outcomes such as depression, posttraumatic stress disorder (PTSD), and reduced cognitive abilities. Other forms of childhood maltreatment have been associated with brain structure or developmental alteration. Our earlier studies elucidated potential discernible effects of PVA and witnessing domestic violence during childhood on brain morphology, in...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Tomoda A Tags: Yakugaku Zasshi Source Type: research

Mission and Vision for the Future in University Pharmacy.
PMID: 27150925 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Teramachi H, Matsushita R Tags: Yakugaku Zasshi Source Type: research

Activity and the Role of Keio University Pharmacy.
Abstract Keio University Faculty of Pharmacy opened an insurance pharmacy on its campus in 2001. This pharmacy was opened with the objectives of 1) educating pharmacists to serve the regional community; 2) heightening students' motivation; and 3) providing practical education geared to the needs of actual healthcare settings. Since my appointment as director in 2003, I have led various initiatives to determine an ideal business model for a university pharmacy. This paper reports these initiatives and discusses the mission and future prospects of university pharmacies. In terms of education, all 4th-year students pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Fukushima N Tags: Yakugaku Zasshi Source Type: research

The Faculties of Pharmacy Schools Should Make an Effort to Network with Community Pharmacies.
Abstract By law, medical faculties are mandated to have a designated partner hospital for the purposes of student practical training. In contrast, pharmacy faculties do not have such a legal requirement for student training in a community pharmacy setting. Nevertheless, there are several public and private universities that do have community pharmacies. However, there is no national university that has established both an educational hospital and a community pharmacy. When Kanazawa University (KU) established a graduate school with a clinical pharmacy course, the faculty of KU deemed it necessary to set up an indep...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Matsushita R Tags: Yakugaku Zasshi Source Type: research

The Vision and Challenges of Hokkaido Pharmaceutical University's Affiliated Pharmacy.
Abstract Hokkaido Pharmaceutical University (HPU), according to its educational mission, seeks to "develop medical professionals who contribute to community medicine", and it has produced more than 6300 graduates since 1974. With recent medical advancements and a progressively aging society, the role of the pharmacist in community medicine has diversified and is increasing in importance. Therefore, in April 2012, the Hokkaido Pharmaceutical University Affiliated Pharmacy was established as a for-profit business of the Educational Foundation of the Hokkaido University of Science, the parent body of HPU. The pharmacy...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Norose T, Manabe T, Furuta S, Watanabe K Tags: Yakugaku Zasshi Source Type: research

Pharmacy Education and the Role of the Local Pharmacy at Gifu Pharmaceutical University Pharmacy.
Abstract Gifu Pharmaceutical University Pharmacy was established in front of Gifu University Hospital (GUH) as a pharmacy attached to the university, the first in Japan in 1998. When GUH moved in 2004, Gifu Pharmaceutical University Pharmacy was built in its current location. One of the priorities of the design of the new facility was easy access to those with disabilities. For example, ramps, wheelchair accessible restrooms, and handicap-friendly waiting-room chairs were installed. In cooperation with GUH, we introduced a two-dimensional bar code system for prescriptions. This promoted the efficiency of compoundin...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Teramachi H Tags: Yakugaku Zasshi Source Type: research

Psychopharmacological Studies in Mice.
Abstract Since 1998, when the laboratory of Medicinal Pharmacology was established in the Graduate School of Pharmaceutical Sciences, Osaka University, I have been interested in psychopharmacological research topics. During this period, we identified a number of novel regulatory mechanisms that control the prefrontal dopamine system through functional interaction between serotonin1A and dopamine D2 receptors or between serotonin1A and σ1 receptors. Our findings suggest that strategies that enhance the prefrontal dopamine system may have therapeutic potential in the treatment of psychiatric disorders. We also found...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Matsuda T Tags: Yakugaku Zasshi Source Type: research

Novel Strategies for Treating Lifestyle-related Diseases Using Various Approaches.
Abstract The number of patients with metabolic disorders is dramatically increasing all over the world. The diseases often exhibit multiple metabolic disturbances including diabetes, hyperlipidemia, and obesity, and so on, recognized as a concept of metabolic syndrome. It is important to consider the common underlying pathophysiological bases of such metabolic diseases at the suggestion of the teachings of a parable, "The blind men and an elephant," whereby each blind man investigates a different part of the elephant. The lesson could even be applicable to each aspect of the disorders. Physical exercise as well as ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Miyamoto L Tags: Yakugaku Zasshi Source Type: research

Factors Influencing the Accurate Administration of Peristaltic Finger Infusion Pumps Attached to Polyvinylchloride Infusion Sets Containing Tris(2-ethylhexyl) trimellitate.
Abstract An accurate continuous intravenous injection via a peristaltic finger infusion pump has been utilized at outpatient clinics recently. An infusion element designed for this pump is necessary for the accurate handling of the pump, and for proper use of this equipment, we need accurate information. Our experiments have shown that medication administration has occasionally been incomplete at the calculated input time when a peristaltic finger infusion pump has been used. In this paper, we have investigated the cause of the delay in the administration time and the effect of the attachment procedure using a comb...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Umemura M, Arai D, Maegawa K, Shigeno K, Wakiya Y Tags: Yakugaku Zasshi Source Type: research

Relationship of Prescribed Drugs with the Risk of Fall in Inpatients.
Abstract Falls are common in elderly patients and are often serious. Several drugs have been associated with an increased risk of fall. Older adults often take multiple drugs for chronic diseases, and thus may be at increased risk from drugs associated with fall. We investigated the association between drug use and falling in hospitalized older people, with the goal of identifying medications that may increase the risk of a fall. A retrospective case control study was performed at the National Hospital Organization Kumamoto Saishunso Hospital in Japan. Medications taken by patients who fell (n=57) were compared wit...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Kozono A, Isami K, Shiota K, Tsumagari K, Nagano M, Inoue D, Adachi R, Hiraki Y, Nakagawa Y, Kamimura H, Yamamichi K Tags: Yakugaku Zasshi Source Type: research

Future Vision of Regulatory Science in the Global Development of Pharmaceuticals and Medical Devices.
PMID: 27040332 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Nakamura M, Ikeda K Tags: Yakugaku Zasshi Source Type: research

New Medical Device Evaluation.
Abstract In this presentation, as a member of the Harmonization by Doing (HBD) project, I discuss the significance of regulatory science in global medical device development and our experience in the international collaboration process for medical devices. In Japan, most innovative medical therapeutic devices were previously developed and exported by foreign-based companies. Due to this device lag, Japanese had minimal opportunities for receiving treatment with innovative medical devices. To address this issue, the Japanese government has actively accepted foreign clinical trial results and promoted global clinical...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Ikeda K Tags: Yakugaku Zasshi Source Type: research

Future Regulatory Science through a Global Product Development Strategy to Overcome the Device Lag.
Abstract Environment that created "medical device lag (MDL)" has changed dramatically, and currently that term is not heard often. This was mainly achieved through the leadership of three groups: government, which determined to overcome MDL and took steps to do so; medical societies, which exhibited accountability in trial participation; and MD companies, which underwent a change in mindset that allowed comprehensive tripartite cooperation to reach the current stage. In particular, the global product development strategy (GPDS) of companies in a changing social environment has taken a new-turn with international ha...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Tsuchii I Tags: Yakugaku Zasshi Source Type: research

Quantitative Decision Making in Drug Development: Pharmacometrics.
Abstract According to the US Food and Drug Administration, pharmacometrics is an emerging science that quantifies drugs, diseases, and trial information to aid efficient drug development and/or regulatory decisions. Quantitative decision making occurs at all stages of drug development. In general, patient-level data are not made available to competitors. However, summary-level data are available. Model-based meta-analysis (MBMA) is a powerful tool for decision making which identifies the candidate position in the market. The limitation of MBMA is the heterogeneity of the treatment effect. In the near future, MBMA a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Suzuki A Tags: Yakugaku Zasshi Source Type: research

Role of Academia in Regulatory Science for Global Drug Development.
Abstract As diseases know no national boundaries, drug development must be designed at a global level. Drugs are highly regulated to maximize the benefits to public health, which is assessed on a regional basis. The complexity and diversity of stakeholders increase dramatically once multiple international regions are involved. Each stakeholder in drug development depends on customized criteria to make decisions for its own benefit. Thus, a huge gap exists among drug discovery researchers, developers, clinicians, patients, and regulatory bodies. With reasonable scientific evidence gathered and analyzed, mutual agree...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Tsukamoto K, Takenaka T Tags: Yakugaku Zasshi Source Type: research

Analysis of Spontaneously Reported Adverse Events.
Abstract Observational study is necessary for the evaluation of drug effectiveness in clinical practice. In recent years, the use of spontaneous reporting systems (SRS) for adverse drug reactions has increased and they have become an important resource for regulatory science. SRS, being the largest and most well-known databases worldwide, are one of the primary tools used for postmarketing surveillance and pharmacovigilance. To analyze SRS, the US Food and Drug Administration Adverse Event Reporting System (FAERS) and the Japanese Adverse Drug Event Report Database (JADER) are reviewed. Authorized pharmacovigilance...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Nakamura M Tags: Yakugaku Zasshi Source Type: research

Regulatory Science in the Review of Drugs and Medical Devices.
Abstract The review of drugs and medical devices is an integral part of regulatory science. The Pharmaceuticals and Medical Devices Agency (PMDA) evaluates the efficacy, safety, and quality of drugs and medical devices after applications are submitted for regulatory approval. The products are approved when their benefits exceed their risks, i.e., an application is approved if the efficacy of the product in patients was demonstrated and the safety of the product is acceptable in view of its observed benefits. However, drugs and medical devices for which efficacy was not clearly demonstrated in clinical trials makes ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Koide A Tags: Yakugaku Zasshi Source Type: research

Current Status and Future Prospects of Nonalcoholic Fatty Liver Disease (NAFLD) in Japan-Feedback from Clinical and Basic Researches to Medical Therapy and Pharmacist Activities.
PMID: 27040339 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Tokuyama S, Ih Kim K Tags: Yakugaku Zasshi Source Type: research

An Overview of NAFLD/NASH in Japan.
Abstract Clinical identity of nonalcoholic steatohepatitis (NASH) has established it as a chronic liver disease since the 1990s in the USA and in the 21st century in Japan, although its significance is not well recognized in Japanese society. It is characterized as a chronic liver disease, differentiated from viral liver disease and alcoholic liver disease. Nonalcoholic fatty liver disease (NAFLD) comprises nonalcoholic fatty liver (NAFL) and NASH. NASH is considered to be the hepatic manifestation of a metabolic syndrome. It is understood that among individuals with NAFLD, NAFL is a benign condition, whereas NASH ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Ryang Kim S, Ih Kim K Tags: Yakugaku Zasshi Source Type: research

Incretin as a Novel Treatment Strategy for NAFLD/NASH.
Abstract Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) have been recognized as metabolic disorders characterized by fatty accumulation in the liver without alcohol consumption. The diseases can cause metabolic syndromes, consisting of obesity, diabetes mellitus (DM), dyslipidemia and hypertension. For the treatment of NAFLD/NASH, losing weight by exercise or diet remains the standard treatment, because no effective pharmacological therapy has yet been developed for NAFLD/NASH. Two incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Takeda Y, Ikeda R, Kondo T Tags: Yakugaku Zasshi Source Type: research

Drug-induced Nonalcoholic Steatohepatitis.
Abstract Nonalcoholic steatohepatitis (NASH) is a chronic progressive liver disease characterized by intense liver steatosis accompanied by hepatocyte destruction, inflammation and fibrous, despite little or no history of alcoholic consumption. There are also cases of drug-induced secondary steatohepatitis. Drug-induced steatohepatitis is a relatively rare type of drug-induced liver disease, but close attention to the possible onset of steatohepatitis is needed when drugs with the potential to induce fatty liver are prescribed for long term use. Estrogen is a factor indispensable to smooth fatty acid β-oxidation i...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Miyamura M, Yokota J, Saibara T Tags: Yakugaku Zasshi Source Type: research

A Future Perspective on the Involvement of n-3 Polyunsaturated Fatty Acid in the Development of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis.
Abstract Nonalcoholic fatty liver disease (NAFLD) is characterized by the pathological accumulation of fat in the liver in the absence of any other disease related to liver steatosis, which includes a wide spectrum of liver diseases ranging from mild asymptomatic fatty liver to nonalcoholic steatohepatitis (NASH) and cirrhosis. Recently, it was reported that NAFLD is characterized by the impaired bioavailability of liver n-6 and n-3 long-chain polyunsaturated fatty acids (PUFAs). That is, compared with healthy individuals, steatosis and steatohepatitis patients have higher n-6/n-3 PUFA ratios. Furthermore, per rece...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Nakamoto K, Obata T, Hirasawa A, Ih Kim K, Ryang Kim S, Tokuyama S Tags: Yakugaku Zasshi Source Type: research

Characteristics and Functional Roles of Opioids Originally Present in Vivo.
Abstract The characteristics and functional roles of opioids originally present in vivo (endogenous opioids) in guinea-pig ileum were investigated. The release of endogenous opioids was determined by the inhibitory twitch response evoked by 0.1 Hz stimulation after 10 Hz stimulation (post-tetanic twitch inhibition). The effects of peptidase inhibitors increased the post-tetanic twitch inhibition, prevented by β-funaltrexamine and nor-binaltorphimine, which are selective μ- and κ-opioid receptor subtype antagonists, respectively. Dopamine receptor antagonists (haloperidol, sultopride and domperidone) increased th...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Ozaki M Tags: Yakugaku Zasshi Source Type: research

Synthetic Studies of Bioactive Heterocyclic Natural Products and Fused Heterocyclic Compounds Based on the Thermal Electrocyclic or Azaelectocyclic Reaction of 6π-Electron or Aza-6π-electron Systems.
Abstract Since 1979, synthetic studies of bioactive heterocyclic natural products and condensed heteroaromatic compounds based on the thermal electrocyclic reaction of 6π-electron or aza-6π-electron systems incorporating the double bond of the principal aromatic or heteroaromatic ring have been conducted by our research group. In this review, five types of electrocyclic and azaelectrocyclic reaction are described: 1) the synthesis of the carbazole alkaloids hyellazole and 6-chlorohyellazole through the electrocyclic reaction of 2,3-bisalkenylindoles; 2) synthetic studies of the pyridocarbazole alkaloids elliptici...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Hibino S Tags: Yakugaku Zasshi Source Type: research

Molecular Mechanisms of Early-stage Adipocyte Differentiation and Multi-functional Roles of Newly Isolated Adipogenic Factors.
Abstract Obesity is a major risk factor for diabetes, hypertension, hyperlipidemia, and arteriosclerosis. Although the middle and late stages of adipocyte differentiation are well characterized, the earliest step in the differentiation process has remained largely unknown. We isolated 102 genes expressed at the beginning of the differentiation of a mouse preadipocyte cell line, 3T3-L1 cells. Because approximately half of these genes were unknown, we named them factor for adipocyte differentiation (fad) genes. I first show how these genes regulate the early stage of adipocyte differentiation. We next generated fad10...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Imagawa M Tags: Yakugaku Zasshi Source Type: research

Development of Radiolabeled Molecular Imaging Probes for in Vivo Analysis of Biological Function.
Abstract Molecular imaging is a newly emerging field aimed at advancing our understanding of biology and medicine through the noninvasive in vivo investigation of cellular molecular events involved in normal and pathologic processes. In this field, researchers and/or clinicians are combining modern tools of molecular and cell biology with state of the art technology in order to noninvasively image living subjects. Various imaging modalities such as optics (fluorescence and luminescence), nuclear magnetic resonance imaging, ultrasound, and radiation are being used to visually capture and study molecular and cellular...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Ueda M Tags: Yakugaku Zasshi Source Type: research

Exploring New Drug Targets through the Identification of Target Molecules of Bioactive Natural Products.
Abstract With the development of cell biology and microbiology, it has become easy to culture many types of animal cells and microbes, and they are frequently used for phenotypic screening to explore medicinal seeds. On the other hand, it is recognized that cells and pathogenic microbes present in pathologic sites and infected regions of the human body display unique properties different from those under general culture conditions. We isolated several bioactive compounds from marine medicinal resources using constructed bioassay-guided separation focusing on the unique changes in the characteristics of cells and pa...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Arai M Tags: Yakugaku Zasshi Source Type: research

Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation-Study of Therapeutic Equivalence.
Abstract The introduction of generic drugs is promoted from the perspective of medical economics. In this context, we need to understand not only the bioequivalence of generic drugs specified in "the Guidelines for Bioequivalence Studies of Generic Products", but also formulation properties to consider their effect on pharmacological therapy. We evaluated the pharmaceutical characteristics of rebamipide formulations, a brand-name drug and two generic drugs, and their clinical functionality by using rat models of gastric mucosal injury induced by non-steroidal anti-inflammatory drugs (NSAIDs). Pharmaceutical evaluat...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 7, 2016 Category: Drugs & Pharmacology Authors: Abe N, Funato H, Hirata A, Nakai M, Iizuka M, Shiraishi H, Jobu K, Yagi Y, Kadota A, Ogi K, Yokota J, Miyamura M Tags: Yakugaku Zasshi Source Type: research

Dose reduction versus dose-interval prolongation in eribulin mesilate monotherapy in patients with metastatic breast cancer: A retrospective comparative study.
Abstract <bibitem lang="en"> It is often necessary to modify the dose or schedule of Eri (eribulin mesilate) because of adverse events. Therefore, we retrospectively investigated the optimal approach for Eri dose adjustment and/or dosage interval adjustment. Patients who received Eri at the institutions affiliated with the Division of Oncology of the Aichi Prefectural Society of Hospital Pharmacists between July 2011 and November 2013 were enrolled in this study. We compared the group that underwent dose reduction without changes to their dosage interval (dose reduction group) with the group that had a ch...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2016 Category: Drugs & Pharmacology Authors: Sasaki T, Oshima Y, Mishima E, Ban A, Katsuragawa K, Nagamatsu H, Yoshioka Y, Tsukiyama I, Hisada T, Itakura Y, Mizutani M Tags: Yakugaku Zasshi Source Type: research

New Developments to Break the Limitations of the Integrated Program-Inclusive Reform of Teaching and Learning by the Jigsaw Method.
PMID: 26935071 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Kodama N, Nagai N, Yasuhara T Tags: Yakugaku Zasshi Source Type: research

Introduction and Evaluation of an Integrated Program to Develop Pharmacotherapeutic Management Skills.
Abstract   Pharmacists must be able to select and collect important information for patient care, to accurately assess and monitor the status of patients, to develop care plans, propose optimal formulations, and provide advice to patients about pharmacotherapy. The core curriculum of Japan's pharmacy education model was revised in 2013 based on the "Basic competencies required of a pharmacist" that should be developed by the time of a student's graduation. Specific behavioral objectives to be acquired include competency in "The ability to implement pharmacotherapeutic management", which involves gaining the abili...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Yamashita M, Norose T, Hayakawa T Tags: Yakugaku Zasshi Source Type: research

Theory and Practice of the Constructive Jigsaw Method in Advancing Domain Knowledge and Skills in Parallel.
Abstract   The Learning Sciences constitute a rapidly expanding discipline that focuses on the learning potential of humans. In this paper, I will discuss the particular learning mechanism involved in the concomitant advancement of domain knowledge and 21st century skills, as well as the Constructive Jigsaw Method of knowledge construction through collaboration-that is, collaborative problem solving. An especially important focus on knowledge construction separates routine experts from adaptive experts. While routine experts develop a core set of skills that they apply throughout their lives with increasing effic...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Masukawa H Tags: Yakugaku Zasshi Source Type: research

Jigsaw Method Is Used to Promote a First Year-student's Understanding of Integrated Subjects at Kobe Pharmaceutical University.
Abstract   In the School of Pharmacy, collaborative learning that includes both problem-based learning (PBL) and team-based learning (TBL) methods, has been introduced as an active learning method into the education of first-year pharmacy students. These methods are an educational approach to teaching and learning that involve groups of students working collaboratively to resolve a problem, complete a task, or develop a product. However, these methods might not aid students who focus more on the results than on the problem-solving process. In addition, the self-efficacy and learning motivation of students who dis...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Kodama N, Koyama J Tags: Yakugaku Zasshi Source Type: research

The Synergistic Effect of Problem-based Learning Combined with the Jigsaw Method in a Pharmacotherapy Course.
Abstract   To promote problem-solving ability within a pharmacotherapy course, we developed new problem-based learning (PBL) and information and communication technologies (ICT) support systems, and introduced the "Jigsaw Method," an active learning method in which, similar to parts of a jigsaw puzzle, students are dependent on each other to create the full picture, to succeed. We conducted 10 PBL modules (one case per module), each lasting one week. To encourage constructive group work, information sharing, and student understanding in the individual modules, we implemented a Jigsaw Method-based wiki worksheet s...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Ohtsu F, Nagamatsu T, Nadai M, Hasegawa Y, Goto N Tags: Yakugaku Zasshi Source Type: research

Approach to the Education of Kampo Medicine by Pharmacognosy Faculty.
PMID: 26935076 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Mimaki Y, Kobayashi Y, Makino T Tags: Yakugaku Zasshi Source Type: research

Kampo Education in the Faculty of Pharmaceutical Sciences at Toho University.
Abstract   In the Faculty of Pharmaceutical Sciences at Toho University, Kampo education commenced 40 years ago through a course titeled "Kampo", which has since been renamed as "Kampo Pharmacology". The current university curriculum offers courses in subjects such as Pharmacognosy and Practical Pharmacognosy for sophomores, Kampo Pharmacology for juniors, and Clinical Kampo Medicine for seniors. Kampo Pharmacology is a subject that bridges "Pharmacognosy" to "Clinical Kampo Medicine". The functions of the crude drugs included in Kampo prescriptions are explained both in terms of efficacy from the perspective of ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Koike K Tags: Yakugaku Zasshi Source Type: research

Approach to Teaching Kampo Medicine at Kyoto Pharmaceutical University.
Abstract   An approach to educating our pharmaceutical students about Kampo medicine in the six-year system of undergraduate pharmacy education at Kyoto Pharmaceutical University is introduced, including the author's opinions. Curriculum revisions have been made in our university for students entering after 2012. In teaching Kampo medicine at present, a medical doctor and an on-site pharmacist share information difficult to give in a lecture with the teaching staff in my laboratory. For example, before the curriculum revision, we conferred with a pharmacist and a doctor in the course "Kampo Medicine A, B" for 4th...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Matsuda H Tags: Yakugaku Zasshi Source Type: research

How to Teach Kampo Medicine in the Age of Internationalization?
Abstract   Given the universal prevalence of complementary and alternative medicines, as well as integrative medicine, the usage of traditional medicine has been gaining in popularity worldwide. Japanese Kampo medicine and traditional Chinese medicine (TCM) are both derived from ancient medicines used in East Asia in the 5th-7th centuries, and have developed independently since the 14th century. Now Kampo medicine and TCM have different theories for the diagnosis and use of crude drugs. Unfortunately, Kampo medicine is not well known in Europe and the Americas; as a matter of practice, TCM is the international st...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Makino T Tags: Yakugaku Zasshi Source Type: research

Education Program of Kampo-medicine for Undergraduates in Preparation for Clinical Setting.
Abstract   Kampo-medicine has become popular in Japanese medical practice combined with western medicine. For example, Daikenchu-To for intestinal obstruction after surgical operation, Shakuyakukanzo-To and Goshajinki-Gan for anti-cancer agents-induced neuropathy, and Yokkan-San for behavioral psychological symptoms of dementia are alternatively used in addition to conventional treatments in Japan. However, combined use of Kampo-medicine and western medicine may cause unexpected adverse events including undesirable drug-drug interactions because Kampo-medicine was not originally developed to be used with western ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Homma M Tags: Yakugaku Zasshi Source Type: research

Kampo Medicine in the New Model Core Curriculum of Pharmaceutical Education.
Abstract   What should we educate for Kampo medicine in the model core curriculum of pharmaceutical education? The curricular core should be discussed considering the points mentioned below. (1) Positioning of Kampo medicine in the Japanese medical care system. Kampo medicine is an authorized medical care category in the National Health Insurance (NHI) program in Japan. The NHI drug price list carries 148 Kampo formulations. According to the report of the Japan Kampo Medicines Manufacturers Association in 2011, approximately 90% of Japanese physicians prescribe Kampo medicines. (2) Differences between Kampo medic...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Kobayashi Y Tags: Yakugaku Zasshi Source Type: research

Evaluation and Exploring Technique for Drug Target Discovery.
PMID: 26935082 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Kamada H, Inoue T Tags: Yakugaku Zasshi Source Type: research

Development of a Drug Discovery Method Targeted to Stromal Tissue.
Abstract   Several diseases are characterized by alterations in the molecular distribution of vascular structures, presenting the opportunity to use monoclonal antibodies for clinical therapies. This pharmaceutical strategy, often referred to as "vascular targeting", has promise in promoting the discovery and development of selective biological drugs to regulate angiogenesis-related diseases such as cancer. Various experimental approaches have been utilized to discover accessible vascular markers of health and disease at the protein level. Our group has developed a new chemical proteomics technology to identify a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Kamada H Tags: Yakugaku Zasshi Source Type: research

Biophysical Characterization of Biopharmaceuticals, Including Antibody Drugs.
Abstract   Biopharmaceuticals, including antibody drugs, are now popular because of their high specificity with low adverse effects, especially in the treatment of cancer and autoimmune diseases. However, because the active pharmaceutical ingredients of biopharmaceuticals are proteins, biophysical characterization of these therapeutic proteins should be required. In this manuscript, methods of chemical and physical characterization of therapeutic proteins are described. In terms of chemical characterization, analysis of chemical modifications of the constituent amino acids is explained. Physical characterization ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Uchiyama S Tags: Yakugaku Zasshi Source Type: research

Structural Study in the Platform for Drug Discovery, Informatics, and Structural Life Science.
Abstract   The Platform for Drug Discovery, Informatics, and Structural Life Science (PDIS), which has been launched since FY2012, is a national project in the field of structural biology. The PDIS consists of three cores - structural analysis, control, and informatics - and aims to support life science researchers who are not familiar with structural biology. The PDIS project is able to provide full-scale support for structural biology research. The support provided by the PDIS project includes protein purification with various expression systems, large scale protein crystallization, crystal structure determinat...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2016 Category: Drugs & Pharmacology Authors: Senda T Tags: Yakugaku Zasshi Source Type: research