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New Trend in Metal-based Drug Research.
PMID: 25832832 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Sakurai H, Odani A Tags: Yakugaku Zasshi Source Type: research

Iron, Aluminum, and Lanthanum-based Drugs for Treatment of Hyperphosphatemia.
Abstract   The control of the serum phosphorus (P) level in chronic kidney disease patients is important because elevated serum P levels are associated with progression of vascular calcification and increased mortality in these patients. In 2014, a novel phosphate binder, ferric citrate hydrate (Riona(®)), became available for the treatment of hyperphosphatemia in Japan, the first country to approve this medication. Ferric citrate hydrate, which relies upon the potent phosphate-binding capacity of ferric iron, inhibits P absorption by forming complexes between ferric iron and dietary phosphate in the gut. The ac...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Matsumura K Tags: Yakugaku Zasshi Source Type: research

Application of radioisotopes for theranostics, a combination of diagnostics and therapy.
Abstract   Radioisotopes emit radiation with various characteristics. These characteristics have been used for various applications of radioisotopes in clinical fields. For example, diagnostic nuclear medicine is a technique that uses gamma-emitted radionuclides with high permeability into the body and can visualize changes in physiological and biochemical processes throughout the distributed and interrelated systems of living tissues and organs. Therapeutic nuclear medicine is a technique that uses beta-emitted radionuclides with high radiation damage to the cell and can be used for internal radiation therapy. T...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Saji H Tags: Yakugaku Zasshi Source Type: research

Decorporation agents for internal radioactive contamination.
Abstract   When radionuclides are accidentally ingested or inhaled, blood circulation or tissue/organ deposition of the radionuclides causes systemic or local radiation effects. In such cases, decorporation therapy is used to reduce the health risks due to their intake. Decorporation therapy includes reduction and/or inhibition of absorption from the gastrointestinal tract, isotopic dilution, and the use of diuretics, adsorbents, and chelating agents. For example, penicillamine is recommended as a chelating agent for copper contamination, and diethylene triamine pentaacetic acid is approved for the treatment of i...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Ohmachi Y Tags: Yakugaku Zasshi Source Type: research

Front-line Research of Idiosyncratic Drug Toxicity.
PMID: 25832836 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Yamada H Tags: Yakugaku Zasshi Source Type: research

Recent findings regarding the mechanism of idiosyncratic drug toxicity.
Abstract   Animal experiments cannot predict the probability of idiosyncratic drug toxicity; consequently, an important goal of the pharmaceutical industry is to develop a new methodology for preventing this form of drug reaction. Although the mechanism remains unclear, immune reactions are likely involved in the toxic processes underlying idiosyncratic drug toxicity: the drug is first activated into a chemically reactive metabolite that binds covalently to proteins and then acts as an immunogen. Therefore, screening tests to detect chemically reactive metabolites are conducted early during drug development and t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Ikeda T Tags: Yakugaku Zasshi Source Type: research

Establishment of Animal Models of Drug-induced Liver Injury and Analysis of Possible Mechanisms.
Abstract   Drug-induced liver injury (DILI) is one of leading causes of attrition during both early and late stages of drug development and postmarketing. DILI is generally classified into the intrinsic and idiosyncratic types. Intrinsic DILI is dose dependent and predictable as exemplified by acetaminophen toxicity. However, the occurrence of idiosyncratic DILI with very low incidence and severe liver damage is difficult to predict because of the complex nature of DILI and poor understanding of its mechanism. In this review, we summarize current knowledge and our accumulated experimental findings on the pathogen...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Oda S, Yokoi T Tags: Yakugaku Zasshi Source Type: research

Predictive genomic markers for severe adverse drug reactions.
Abstract   Severe adverse drug reactions are an important issue to be considered during proper drug usage in postmarketing period. Most severe adverse reactions are idiosyncratic and unrelated to their pharmacological actions via primary targets. Although these reactions were not predictable, recent developments in the field of genomics have revealed closely associated markers responsible for some severe adverse reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). This review demonstrates genomic biomarkers for SJS/TEN and drug-induced liver injury (DILI) that were found mainl...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Saito Y, Kodama S, Sugiyama E, Nakamura R Tags: Yakugaku Zasshi Source Type: research

Gene Regulation Involved in the Formation of Long-term Memory.
Abstract   My former research focused on silk fibroin gene transcription. The in vivo transcription initiation site of the fibroin gene, which is similar to the site corresponding to the 5'-terminal of mature fibroin mRNA, was determined. By developing a cell-free transcription system prepared from silk glands, it was found that the upstream region of the fibroin gene is responsible for efficient transcription initiation, which has enhancer-like features. More recent research has switched my focus to cellular neurobiology to understand the molecular mechanisms of long-term memory at the level of gene expression i...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Tsuda M Tags: Yakugaku Zasshi Source Type: research

Clinical pharmacology and pharmacoepidemiology for medication safety in clinical settings.
In conclusion, our achievement in accurately assessing these would contribute to medication safety and the appropriate use of medicines in clinical settings. PMID: 25832841 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Kawakami J Tags: Yakugaku Zasshi Source Type: research

Preparation and physicochemical study of the preservation of nanoparticles.
In this study, trisaccharides, tetrasaccharides, and pentasaccharides were added to nanoparticle suspensions, followed by rehydration of the samples, which had been either dried normally or freeze-dried. The particle size after rehydration was measured. In addition, each powder was measured using a powder X-ray diffractometer and thermal analysis device to investigate the correlation between the nanoparticles' aggregation and the crystal form of saccharides. The diameter of the nanoparticles was maintained when it was freeze-dried, while particle aggregation occurred when normally dried samples were used. In addition, crys...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Kamiya S Tags: Yakugaku Zasshi Source Type: research

Analysis of phthalates in aromatic and deodorant aerosol products and evaluation of exposure risk.
Abstract   We established an analytical method for the detection of seven phthalates, dimethyl phthalate, diethyl phthalate (DEP), benzyl butyl phthalate, di-i-butyl phthalate, dibutyl phthalate (DBP), diethylhexyl phthalate (DEHP), and di-n-octhyl phthalate, using an ultra high performance liquid chromatograph equipped with a photodiode array detector. This method is quick, with minimal contamination, and was applied to the analysis of aromatic and deodorant aerosol products. Phthalates were detected in 15 of 52 samples purchased from 1999 to 2012 in Yokohama. Three types of phthalate (DEP, DBP, DEHP) were detec...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Sato Y, Sugaya N, Nakagawa T, Morita M Tags: Yakugaku Zasshi Source Type: research

Elevated serum lithium concentration due to switch from parenteral nutrition alone to parenteral with enteral nutrition.
We report a patient with elevated serum lithium concentration caused by switching from parenteral nutrition alone to parenteral with enteral nutrition. A 73-year-old female inpatient was treated with lithium carbonate 600 mg/d for manic episodes of bipolar disorder. Her serum lithium level was maintained at 0.57-0.79 mEq/L. She was administered total parenteral nutrition owing to difficulty in oral intake. Her diet contained 4.8-5.8 g/d of sodium chloride. After this, parenteral with enteral nutrition was initiated. The total sodium chloride intake decreased from 6.3 to 3.0-4.0 g/d following this change. On day 15 after in...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 5, 2015 Category: Drugs & Pharmacology Authors: Goto H, Tomita T, Doki S, Nakanishi R, Kojima C, Yoneshima M, Yoshida T, Tanaka K, Kohda Y Tags: Yakugaku Zasshi Source Type: research

Necessity of Advance Pharmaceutical Education and Research for Upbringing of the Pharmacist Who Can Make a Immediate Decision in Patient's Problems.
PMID: 25747205 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ooi K, Takamura N Tags: Yakugaku Zasshi Source Type: research

The necessity for pharmaceutical education on perioperative care-considering the activities of operating room pharmacists in relation to types of anesthetic operations involved.
Abstract   In an effort better to understand the application of pharmaceutical services in the operating room (OR) we conducted a survey among OR department directors of 526 hospitals throughout Japan. A total of 202 directors responded to the survey. Pharmacists are expected to achieve better outcomes in pharmacotherapy as well as play major roles as members of diverse perioperative care teams. Besides implementing medication safety standards, pharmacists' roles include optimizing drug therapy and other clinical interventions, both in OR and wards. Presently, few pharmacists in Japan participate in perioperative...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Shibata Y, Kawamoto M, Kihira K Tags: Yakugaku Zasshi Source Type: research

Practice of drug monitoring based on comprehensive pharmaceutical judgment.
Abstract   With the revisions to the pay for performance of pharmaceutical service of inpatients in April 2012, the ward permanent time of pharmacists grew longer than previously; however, there are as yet few reports on the pharmaceutical outcome of the new medical service. To improve the pharmaceutical service requires that pharmacists collect useful medical information and extract the problems of pharmaceutical care for inpatients. Since many cases of treatment with multidrug regimens are regularly performed, pharmacists cannot contribute to medical treatment only by knowledge of a single disease. Therefore qu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Katayama T Tags: Yakugaku Zasshi Source Type: research

Health assessment of local residents who made full use of symptomatology skills and test device.
Abstract   A strategy named "Japan is back" adopted in June 2013 specifies that pharmacies shall be regarded as community-based places where health-related information is provided, and the public shall be encouraged to use the services of pharmacies and pharmacists who can advise on health and appropriate use of over-the-counter (OTC) drugs, and promote self medication. In Japan there are approximately 55000 pharmacies and 260000 pharmacists, and community residents are recommended to use these resources. As advisors on healthcare in the community, pharmacists are required to make judgments regarding drug use in ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Akagawa S, Morikawa N, Ikeda K, Okazaki T, Takahashi S Tags: Yakugaku Zasshi Source Type: research

Key points in clinical pharmaceutical education and research, as seen from pharmaceutical consultation clinics.
Abstract   Pharmaceutical education was expanded to a 6-year system in 2006, in an efforts to enhance clinical pharmaceutical research and education. Since that time, pharmacists have attempted to participate in medical all aspects of medical care, but an environment in which they can master direct pharmaceutical techniques for patients has not yet been sufficiently developed. This is because pharmaceutical education emphasizes the acquisition of knowledge and has not reached the point where it cultivates minds that can adapt to the multitude of situations that are envisaged in medical settings. By incorporating ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ooi K Tags: Yakugaku Zasshi Source Type: research

Necessity of Research of Pharmaceutical Departments in the Creation of New Pharmaceutical Skills through Technical Education of Physical Assessment.
Abstract   Physical assessment skills are now being more widely accepted by pharmacists and pharmaceutical departments than in the past. This is explained by the realization that pharmacists can prevent serious adverse effects and evaluate drug efficacy for their patients through assessment, thus providing effective medical care. However, is that all physical assessment can provide to pharmacists and pharmaceutical students? These students, in turn, should recognize the "need for skill" and the "pleasure to be gained in acquiring that skill" through the physical assessment performed by doctors. They should also r...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Takamura N, Tokunaga J, Ogata K, Setoguchi N Tags: Yakugaku Zasshi Source Type: research

The creation of useful analytical tools to elucidate biological phenomena.
PMID: 25747211 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kishikawa N, Todoroki K Tags: Yakugaku Zasshi Source Type: research

Chemiluminescence assay for the investigation of reactive oxygen species generator.
Abstract   Quinones play critical roles in biological systems, but are also regarded as a class of toxins that can cause oxidative stress in living cells, and the involvement of quinone-based reactive oxygen species in oxidative stress has been reported. In biological systems, quinones are reduced to semiquinone radicals by the enzyme NADPH:quinone reductase. Next, semiquinone radicals react with dissolved oxygen to form superoxide anion, which reacts with biological molecules to cause oxidative stress. On the other hand, chemiluminescence reagents such as luminol can emit chemiluminescence after oxidation by rea...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kishikawa N, Kuroda N Tags: Yakugaku Zasshi Source Type: research

Development and Application of FD-LC-MS/MS Proteomics Analysis Revealing Protein Expression and Biochemical Events in Tissues and Cells.
Abstract   It is routine to search for and recognized genetic defects in human disorders to provide knowledge for diagnosis, treatment, and protection against diseases. It is also important to investigate and demonstrate the cause of a disease from the proteomic perspective, because intracellular signaling systems depend on protein dynamics. Demonstrating changes in protein levels enables us to understand biochemical events during the initiation and progression of a disease. To understand changes in protein levels in tissues and cells, we have developed a novel proteomics approach, FD-LC-MS/ MS. This consists of ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ichibangase T, Imai K Tags: Yakugaku Zasshi Source Type: research

Highly Selective Analysis of Biogenic-related Compounds Utilizing Fluorous Chemistry.
Abstract   Perfluoroalkyl-containing compounds are highly fluorous, meaning that they have a remarkable affinity for one another and effectively exclude non-fluorous species. Utilizing this unique property, we have developed a fluorous derivatization with a liquid chromatographic analysis method for highly selective analysis of target analytes. Although most previous methods focused on extremely sensitive detection-oriented derivatization, the fluorous derivatization method involves highly specific separation for analytes. This method includes perfluoroalkylation of analytes with a fluorous reagent, and separatio...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Hayama T Tags: Yakugaku Zasshi Source Type: research

Development of HPLC analysis methods for therapeutic monoclonal antibodies.
Abstract   Therapeutic monoclonal antibody (mAb) preparations are produced from cultured cells; therefore, detailed and multidimensional analyses of their heterogeneities are required. We analyzed five commercially available mAb preparations by high-temperature reversed-phase LC using a wide-pore core-shell column for pluralistic quality assessment. At a highly elevated column temperature, isopropanol with high eluotropic strength coefficients and a wide-pore core-shell type octyl column showed good peak resolution of the investigated mAbs and their related constituents. We used this method to estimate the residu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Todoroki K Tags: Yakugaku Zasshi Source Type: research

Next Generation Type Formulation Developed Using Innovation to Overcome Trade-offs between Patient-oriented Approach and Clinical Effectiveness of Formulation.
PMID: 25747216 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Uchida T, Namiki N Tags: Yakugaku Zasshi Source Type: research

Trade-offs in the Development of Various Dosage Form (Overview).
Abstract   In this symposium we focused on trade-offs which might occur in the process of development of many types of formulation and corresponding dissolution methods. Firstly, we focused on a solubility-permeability trade-off in the case of micelle with surfactant or molecular complex with CyD. The micelle would be successful in increasing drug solubility, however it rather decreased permeability of model drug progesterone (Biopharmaceutics Classfication System (BCS) Class II) as an overall flux. Secondly in order to reduce bitterness of branched chain amino acid (BCAA), increasing particle sizes of each amino...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Uchida T Tags: Yakugaku Zasshi Source Type: research

Trade-offs in Oral Drug Product Development.
This article introduces examples of such innovations which have been successful in doing this, as well as some encountered in the oral formulation development and in the selection of proper dosage forms. Based on these examples, points to be considered in order to produce the drug product are thoroughly discussed. PMID: 25747218 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kondo H, Sako K Tags: Yakugaku Zasshi Source Type: research

Clinical functionality required for orally disintegrating tablets selected as the next generation type.
Abstract   Orally disintegrating tablets (ODTs) are currently widely used in drug therapy and are clinically attractive, because they are suitable for administration to patients with dysphagia and improve adherence, both of which increase the possibility of achieving the expected therapeutic effect. These properties of ODTs, which increase treatment effectiveness, are termed their "clinical functionality", and ODTs with a high clinical functionality are required to meet the increasing need for these tablets. For example, there is a need for development of a clinically effective ODT with superior disintegrating pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Namiki N Tags: Yakugaku Zasshi Source Type: research

Oral dosage forms for children: acceptability and palatability.
Abstract   Children generally reject taking medicine which does not have a favorable shape, taste, flavor, etc. However, if a child who needs to take a medicine, rejects taking it, he might never recover from his condition. When a child is unable to take medicine orally, it is intravenously administered, and he and his caregivers then may experience stress. Syrups and suspensions are considered as favorable types of dosage forms in which to orally administer medicine to infants and children. However, they may have disadvantages such as solubility, a bad taste, portability problems or required refrigerator storage...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kojima J Tags: Yakugaku Zasshi Source Type: research

Development of a novel oral jelly formulation for elderly patients.
Abstract   Deterioration of the swallowing function in elderly persons and drug refusal among the behavioral abnormalities in Alzheimer's disease (AD) are commonly reported. Therefore, we developed an easy-to-swallow jelly formulation of Donepezil HCl which AD patients can take as a dessert. The development process, however, was full of trade-off problems. (1) Need for evaluating the taste of a drug product vs. Safety of human sensory evaluation of the taste. The trade-off was resolved by using a taste sensor. (2) Speed of development vs. Safety of the manufacturing process. We put priority on the safety rather t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Harada T, Yasuoka K, Sakurai M, Murase T, Owaki T Tags: Yakugaku Zasshi Source Type: research

Development of injection containers for patient and medical staff.
Abstract   Recently, there has been a transition from glass to plastic injection containers in Japan. In our previous study, we suggested that plastic containers had less impurity contamination than glass containers. However, the use of some plasticizers has been limited because of their endocrine disrupting effects. Therefore, contamination has been a concern due to chemicals in injection solution packed with plastic containers. Indeed, in our recent study, photoinitiators were detected in an injection solution coming from plastic containers. Photoinitiators mainly exist in ink. We therefore speculated that ink ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kawasaki Y, Sendo T Tags: Yakugaku Zasshi Source Type: research

The role of formulation and dosage form in vaccine.
Abstract   The importance of vaccination has recently been widely recognized among Japanese people with a growing interest in vaccine. On the other hand, because vaccine is administrated to healthy people, it has had a difficult history due to overreaction to adverse events. With the recent rapid increase in the rate of vaccination, however, it is essential to correct the understanding of the public as to the risk and benefit of vaccine. Life spans around the world and infectious diseases are closely related, and vaccine certainly contributes to the control of the latter. Research and Development (R&D) of nov...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kikuchi M Tags: Yakugaku Zasshi Source Type: research

What is proper drug information for patients to minimize risk?∼constructing drug guide for patients∼.
PMID: 25747224 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Yamamoto M, Sugimori H Tags: Yakugaku Zasshi Source Type: research

Present state and future tasks of "drug guide for patients".
Abstract   Safety information on drugs is provided through package inserts, which are the most basic tool offered by pharmaceutical companies, "Emergency Safety Information" and "Pharmaceuticals and Medical Devices Safety Information", etc. issued by the Ministry of Health, Labour and Welfare (MHLW). In addition, the Pharmaceuticals and Medical Devices Agency (PMDA) recently established an information website, and the provision of enhanced information is now being promoted not only for health care professionals but also for patients. "Drug Guide for Patients" is one of the information tools for patients. The "Dru...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Isozaki M Tags: Yakugaku Zasshi Source Type: research

Drug Information for Patients (Package Leaflets), and User Testing in EU.
Abstract   Patients and consumers have desired high quality drug information in their pharmacotherapy, and are entitled to receive it. It is desirable that the information should be aimed at shared decision-making between patients and healthcare professionals about medications. The quality of drug information available to patients should also be assured. With an aim to improve the quality of "Drug Guide for Patients", we investigated Patient Information Leaflets (PILs) which are approved by the Medicines and Healthcare Products Regulatory Agency (MHRA) in the United Kingdom (UK) with regard to the criteria of dev...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Yamamoto M, Doi H, Furukawa A Tags: Yakugaku Zasshi Source Type: research

Review of drug information provided to patients from the viewpoint of hospital pharmacists.
Abstract   Risks for patients and consumers can be minimized depending on how they are provided appropriate drug information. Therefore, from the viewpoint of hospital pharmacists, I would like to report on how information should be provided in order to minimize patient risk. For example, there is an ongoing opinion that the provision of easy-to-understand drug information to patients and consumers "does not appear necessary". The reasons for this include the following: Because the level of understanding varies greatly among patients, it is difficult to define what "easy-to-understand" information entails; rather...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Orii T Tags: Yakugaku Zasshi Source Type: research

Findings from a questionnaire survey on new guidelines for preparing drug guide for patients and a perspective from a pharmaceutical company as the information provider.
Abstract   Draft versions of two products of based on a "Drug Guide for Patients" have been prepared the guidelines proposed in "Research on risk communication between patients and healthcare professionals regarding information on safety measures for drugs, etc." by Health and Labour Sciences Research Grants. We conducted a questionnaire survey on the draft to identify issues regarding the contents and their preparation from the viewpoint of pharmaceutical companies as authors. The questionnaire results indicated that, the segments of the contents of the "Drug Guide for Patients" based on the new guidelines are g...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Asada K Tags: Yakugaku Zasshi Source Type: research

What is a medication guide suits patients' needs?
Abstract   In order for a patient to read a medication guide and develop appropriate behavior regarding use of the medication, the guide should suit patients' needs. In medical care, the primary needs of patients are preventing/curing disease and/or relieving symptoms. Certainly, patients would like knowledge about what can be expected after taking a medication. However, current "Drug Guides for Patients" are based on drug labeling, which is essentially a medically sophisticated instruction manual for medical professionals who have existing knowledge about the medical treatment of the disease. Thus, there seems t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Sato T Tags: Yakugaku Zasshi Source Type: research

Development of metallomics research on environmental toxicology.
Abstract   Metallomics is newly coined terms and defined as a comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type. Then, metallome is defined as the entire category of metalloproteins and any other metal-containing biomolecules. Metallomics and research on metallome require analytical techniques that can provide information on the identification and quantification of metal/metalloid-containing biomolecules. This concept has been called speciation, and the acquisition of data according to the concept is performed using hyphenated techniques involving both separation a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ogra Y Tags: Yakugaku Zasshi Source Type: research

Pharmacokinetics characteristics of dexamethasone in crush syndrome model rats.
Abstract   Crush syndrome (CS) is characterized by ischemia/reperfusion-induced rhabdomyolysis and subsequent systemic inflammation and has a high mortality rate, even when treated with conventional therapy. In previous studies, we demonstrated that treatment of rats with acute lethal CS using dexamethasone (DEX) had therapeutic effects in laboratory findings and improved the clinical course of CS. However, because the application of DEX in CS therapy is unknown, evaluation of the pharmacokinetic parameters of DEX was considered essential to support its clinical use. Here, we investigated the pharmacokinetic char...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Murata I, Otsuka A, Hara C, Motohashi R, Kouno S, Inoue Y, Kanamoto I Tags: Yakugaku Zasshi Source Type: research

Fundamental Study of Memory Impairment and Non-cognitive Behavioral Alterations in APPswe/PS1dE9 Mice.
Abstract   In addition to cognitive decline, Alzheimer's disease patients also exhibit non-cognitive symptoms commonly referred to as behavioral and psychological symptoms of dementia, or BPSD. These symptoms have a serious impact on the quality of life of these patients, as well as that of their caregivers, but there are currently no effective therapies. The amyloid β-peptide (Aβ) is suspected to play a central role in the cascade leading to Alzheimer's disease, but the precise mechanisms are still incompletely known. To assess the influence of Aβ pathology on cognitive and non-cognitive behaviors, we examine...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Taniuchi N, Niidome T, Sugimoto H Tags: Yakugaku Zasshi Source Type: research

Learning Outcomes of Six-year Pharmaceutical Education Program.
PMID: 25759036 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Nakamura A, Hasegawa Y, Kamei M Tags: Yakugaku Zasshi Source Type: research

Outcome of the 6-year curriculum for pharmacy education: "contribution to medical care and society: how will I act as a pharmacist in the future?"-a report on the 3rd national student workshop.
Abstract   In August 2013, the Pharmaceutical Society of Japan held the Third National Student Workshop in Tokyo. A total of 88 people-70 sixth-year undergraduate students from 70 universities, and 18 alumni who had participated in the First and the Second Workshops-attended this Workshop. The theme of this Workshop was "Contribution to medical care and society: How will I act as a pharmacist in the future?" The first day took the form of a World Café, with participants exchanging information on such topics as, "The purpose for choosing a pharmacy major, and my achievement status", "My favorite aspects of my col...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kamei M, Imoto Y, Otowa R, Shida M, Hirai Y, Nakamura A Tags: Yakugaku Zasshi Source Type: research

Introduction of Outcome-based Education in Pharmaceutical Education in Japan.
Abstract   Although Japanese medical and pharmaceutical educators have been interested in outcome-based education (OBE) in recent years, there are still many difficulties and problematic concepts involved in curriculum building, especially in determining objectives and assessment methods. From 2015, OBE will be incorporated in a model core curriculum of pharmaceutical education in Japan. In this paper, we will introduce the outline of an operative sample of OBE derived from the National Competency Standards Framework for Pharmacists in Australia. The products shown in this paper are examples of standards, element...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Takahashi H, Kosano H Tags: Yakugaku Zasshi Source Type: research

Design of spiral curriculum for pharmacy students to reach the outcome.
Abstract   The third advanced workshop of the Pharmaceutical Society of Japan for pharmaceutical teachers was held from October 12th to 14th, 2013, and participants discussed an outcome-based approach to curriculum development in pharmacy education. In this article, I report the outcome-based spiral curriculum model of group 2A, which was designed to enable pharmacy students to understand a patient's condition, and to provide a basic practical ability in medical therapy. In the curriculum, pharmacy students will learn biochemistry and functional morphology in the first and second years, skills to interview patien...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Sato E Tags: Yakugaku Zasshi Source Type: research

Program to Learn about the Empowerment: Diabetic Theater, a Workshop Including Drama and Discussion.
Discussion. Yakugaku Zasshi. 2015;135(3):349-50 Authors: Okada H PMID: 25759040 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Okada H Tags: Yakugaku Zasshi Source Type: research

"Throw your hammer!" the essence of patient empowerment in diabetes.
Abstract   The empowerment approach to patients with diabetes is a philosophy that was introduced by Robert M. Anderson and Martha M. Funnell of Michigan Diabetes Research and Training Center in the 1990s. This approach is based on the observation that more than 98% of diabetes care is performed by patients themselves. Dr. Anderson, Ms. Funnell, and their colleagues found that every patient has a right and an ability to solve his/her own problem in his/her own diabetes. Therefore healthcare providers should provide support for patients own endeavors. Empowerment has three essential elements: 1) the patient is cen...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Okazaki K Tags: Yakugaku Zasshi Source Type: research

Diabetes theater in kumamoto: scenario of the diabetes theater and contents of discussion.
Abstract   Diabetes Theater (DT) is reenactment of pharmacists treating their patients during medical interviews. DT shows different pharmacists treating their patients using different methods. After the performance, the participants can learn from reflecting on the plays and their own work. At the 134th Annual Meeting of the Pharmaceutical Society of Japan, Kumamoto we performed 3 plays. The plays were about a diabetic patient with hypoglycemia who consults 3 pharmacists who have 3 different approaches. Clinical pharmacists in Kumamoto performed and created DT. After DT, we received responses for each play from ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Nishimura H, Okada H Tags: Yakugaku Zasshi Source Type: research

Evaluation of diabetes theater: results of questionnaire survey and discussion.
In conclusion, DT was well accepted by attendances as a unique program to learn effective patient communication skills and thereby achieve better patient-pharmacist relations. Our findings suggest that DT might be an interesting approach to improve attitudes of pharmacists in diabetes care with the aim of empowerment. PMID: 25759043 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Okada H Tags: Yakugaku Zasshi Source Type: research

In what ways can we expand on empowerment to pharmacists?
Abstract   The number of Japanese patients with chronic diseases is increasing year by year largely because of the acceleration of demographic aging and lifestyle changes in Japan. Although many patients with chronic diseases receive their medications from pharmacists, many community pharmacists have not changed their communication style with their patients. Empowerment is the basic idea that patient support is not widely known by pharmacists but the certified diabetes educator (CDE). We started Diabetes Theater, a program for healthcare providers that includes short drama and discussion with attendees, in 2009. ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Okada H Tags: Yakugaku Zasshi Source Type: research