Medicine RSS Search Engine

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog.subscribe with FeedlySubscribe to this data using Feedly.

This page shows you the latest items in this publication.

Aim at the innovation of novel drug development.
PMID: 24694803 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Yamada H Tags: Yakugaku Zasshi Source Type: research

Impact of microdose clinical trials in the preclinical stage.
In this study, we examined microdose trials performed in the preclinical stage for two first-in-class compounds with a new mechanism of action. These compounds showed species difference in first pass metabolism in the digestive tract and liver, causing uncertainty in prediction of disposition in humans. For this reason, first-in-human microdose clinical trials were performed. The results showed that the two compounds had effective blood concentrations after oral administration at a dose of 100 mg qd. Administration of an extremely small dose of one (14)C-labeled compound permitted identification of major metabolites. No to...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Kim S Tags: Yakugaku Zasshi Source Type: research

Challenges of imaging as a biomarker in drug research and drug.
Abstract   Positron emission computed tomography (PET) imaging is a clinically translatable technology with the potential to accelerate drug research and development. Therapy monitoring by non-invasive PET imaging study allows a straightforward translation from preclinical to clinical research. In fact, PET imaging is making a major contribution to drug development today and will continue to grow in value. We hereby demonstrate that PET imaging capabilities and our experiences focused on oncology and central nervous system (CNS) therapeutic areas in drug research and development. PET with labeled anticancer drug ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Miyoshi S Tags: Yakugaku Zasshi Source Type: research

Knowledge-based Pharmcodynamics Biomarkers Implementation Using Commercially Available Databases in Early-stage Clinical Trials.
Abstract   The premise of the implementation of eligible pharmacodynamic biomarkers (PD markers) in clinical development of drugs is based on their qualification and understanding of human disease networks on a molecular level, which may be relevant to risk factors, pathogenesis, prognosis, and relapse/remission. Especially, information on PD markers characterized with drug exposure in target tissues, drug binding to target molecules, and linkage to clinical endpoints in early drug development stage can be critical for GO/NO GO decision for the next late clinical stages. Moreover, early confirmation of reliable b...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Goto N, Suzuki M Tags: Yakugaku Zasshi Source Type: research

Use of GWAS for Drug Discovery and Development.
Abstract   The Human Genome Project was completed in 2003. A catalog of common genetic variants in humans was built at the International HapMap Project. These variants, known as single nucleotide polymorphisms (SNPs), occur in human DNA and distributed among populations in different parts of the world. By using the Linkage Disequilibrium and mapping blocks are able to define quantitative characters of inherited diseases. Currently 50 K-5.0 M microarray are available commercially, which based on the results of following the ENCODE & 1000 genome projects. Therefore the genome wide association study (GWAS) has b...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Liou SY Tags: Yakugaku Zasshi Source Type: research

The current issues on development and clinical use of companion diagnostics and prospects of personalized medicine for the future.
Abstract   Recently companion diagnostics (CoDx) have been getting more importance to promote personalized medicine which can improve not only the efficacy and safety of treatments but also increase the cost-effectiveness of medication. In July 2011, the U.S. Food and Drug Administration (FDA) notified the draft guidance for development of CoDx that recommends co-development of CoDx and a new drug as the best practice. The Ministry of Health, Labour and Welfare in Japan also issued on July 1, 2013, their official notification regarding considerable items on co-development of CoDx if the drug needs its dedicate di...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Tazawa Y Tags: Yakugaku Zasshi Source Type: research

Life-oriented Chemistry in Pharmaceutical Sciences-Chemistry Challenge to Mystery of Life-.
PMID: 24694809 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Sasaki S, Futaki S Tags: Yakugaku Zasshi Source Type: research

A visualization tool for oligomerization and internalization of membrane proteins in living cells: coiled-coil labeling method.
Abstract   Genetic fusion of fluorescent/luminescent proteins to a target protein for specific labeling in living cells has been widely used to investigate the intracellular trafficking and oligomerization of the proteins. However, several limitations of fluorescent/luminescent proteins, such as considerable size, difficulty in controlling labeling ratio in multicolor labeling, can obscure true behaviors of the target proteins. To overcome these difficulties, post-translational labeling methods using pairs of small genetically-encodable 'tags' and synthetic 'probes' targeting the tags have been widely studied in ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Yano Y, Kawano K, Omae K, Takeda Y, Matsuzaki S, Matsuzaki K Tags: Yakugaku Zasshi Source Type: research

Chemical approach to analyze the physiological function of phospholipids with polyunsaturated Fatty acyl chain.
Abstract   Polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) occur in biological membranes as acyl groups of phospholipids and exhibit remarkable physiological activities. In human, they have various beneficial effects on health such as protective effects against cardiovascular disease, inflammation, and cancer. We have been studying their physiological functions in bacteria, which have a much simpler membrane structure than eukaryotes. We found that the cell division of a marine bacterium, Shewanella livingstonensis Ac10, is inhibited and shows growth retardation by d...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Kurihara T, Kawamoto J Tags: Yakugaku Zasshi Source Type: research

Reactive Oxygen Species Signaling and Redox Homeostasis Regulated by 8-Nitro-cGMP.
Abstract   An emerging aspect of redox signaling is the signaling pathway mediated by electrophilic byproducts, such as nitrated cyclic nucleotide (8-nitro-cGMP), generated via reactions of reactive oxygen species (ROS), NO, and their secondary products. We recently clarified that enzymatically-generated hydrosulfide derivatives regulate the metabolism and signaling of 8-nitro-cGMP. Although hydrogen sulfide was proposed to be a gaseous signaling mediator, its exact nature and physiological functions remain obscure. We thus found that particular hydropersulfide derivatives rather than hydrogen sulfide greatly ame...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Akaike T Tags: Yakugaku Zasshi Source Type: research

Quantitation of cellular phosphorylation dynamics by phosphoproteomics approaches.
Abstract   Reversible phosphorylation of proteins controlled by kinases and phosphatases is one of the most ubiquitous post-translational modifications, and regulates a variety of cell functions through cellular signal transduction pathways. These signals are involved in various diseases such as cancer and rheumatism, and often cause the disease itself or drive the progression. Quantitative phosphoproteomics based on liquid chromatography-tandem mass spectrometry combined with phosphopeptide enrichment and stable isotope labeling allows profiling thousands of phosphorylation sites on human proteins and has been a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Ishihama Y, Imami K Tags: Yakugaku Zasshi Source Type: research

Role of the Critical Period in Sex and Brain Differentiation: Learning from Dioxin-induced Disorders in Next Generations.
Abstract   The sexual differentiation of animal fetuses and infants needs stimuli by sex steroids, which are produced in their own gonads, during a short window ('critical period') of pre- and post-natal periods. Our laboratory has conducted a series of studies focusing on the damage to next generations by dioxins. When pregnant rats are exposed to a prototype of dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 1 μg/kg), sexual immaturity such as defects in copulation behavior as well as growth retardation emerges in their pups. We have provided evidence that such disorders are evoked, if not all, from a trans...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Yamada H, Takeda T, Koga T, Ishii Y Tags: Yakugaku Zasshi Source Type: research

Pharmacological studies on neurodegenerative diseases focusing on refolding and degradation of unfolded proteins in the endoplasmic reticulum.
In this study, we identified protein-disulfide isomerase (PDI) upregulation by hypoxic stress in the ER of rat brains/astroglial cells. PDI overexpression attenuates hypoxia-induced neuronal apoptosis. In the brain autopsy of patients with sporadic Alzheimer's and Parkinson diseases, PDI was found to be S-nitrosylated, which reduced chaperone activity of PDI, suggesting the involvement of PDI in these diseases. In addition, we identified the novel E3 ubiquitin ligase HRD1 and observed that HRD1 activates degradation of Parkin-associated endothelin receptor-like receptor (Pael-R). HRD1 suppresses ER stress and Pael-R-induce...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Nomura Y Tags: Yakugaku Zasshi Source Type: research

Influence of Temperature and Humidity on Physico-pharmaceutical Characteristics of Rasilez(®) Tablets.
We examined the influence of temperature and humidity on the physico-pharmaceutical characteristics (mass, volume, hardness, elution) of RTs. The RTs were preserved under conditions in which the temperature and humidity were altered using the second-order spherical composite experimental design for multi-objective problems. The characteristics of RTs were influenced more by the humidity than temperature, and differed markedly with over 55% relative humidity (RH). The mass and volume were increased with increasing humidity, and the tablets swelled. The hardness after vacuum-drying of the tablets, which preserved moisture co...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Nakamura Y, Nakajima T, Iwata M, Hayashi Y, Takayama K, Saito H, Sako K, Matsuda Y, Kimura M Tags: Yakugaku Zasshi Source Type: research

Problems of Collaboration between Community and Hospital Pharmacists for Cancer Chemotherapy and Proposed Corrective Measures: KJ Method Based Identification and Planning Workshop.
Abstract   We conducted a workshop that aimed to address the problems of collaboration between community and hospital pharmacists to provide safe outpatient chemotherapy and promote continuous collaboration. Thirty-nine pharmacists in Gunma were enrolled in the workshop and divided into five groups. Each group comprised similar number of community and hospital pharmacists in the neighboring area. Participants in these groups discussed using the KJ method and identified the following important and urgent problems; "lack of collaboration between hospitals and pharmacies" and "lack of exchanging patients' informatio...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Satoh H, Miki A, Maejima K, Iizuka K, Yamaga S, Sakashita K, Takano Y, Takahashi Y, Tajiri K, Takechi Y, Shimada M, Suzuki M, Sawada Y Tags: Yakugaku Zasshi Source Type: research

The Investigation of Understanding and Comfort of Patients Taking Divigel(®) 1 mg.
In this study, we investigated the understanding of medicines and diseases of patients receiving HRT and discuss the approaches pharmacists can take to improve patients' adherence. Thirty-seven patients (mean age 51.7±3.6 years) taking estradiol gel (Divigel(®) 1 mg) completed a questionnaire asked by their pharmacist. Responses indicated 70% of patients failed to use the gel as prescribed, and they had poor knowledge of both the sites where the gel shouldn't be applied and appropriate measures to take if having forgotten to apply the gel (43% and 11% correct understanding, respectively). Since the duration of HRT treatm...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Soda M, Ogawa K, Harada Y, Kawamoto S, Tanaka M, Yamaguchi M, Takahashi C, Ueno A, Osada T, Oguri A, Yamamura K Tags: Yakugaku Zasshi Source Type: research

Errata: in vitro and in silico approaches to evaluate usefulness and safety of chemical compounds applied or exposed on skin.
PMID: 24694819 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 6, 2014 Category: Drugs & Pharmacology Authors: Sugibayashi K, Todo H, Kadhum WR Tags: Yakugaku Zasshi Source Type: research

Recent topic of kansei biosensors on taste and odor sensing systems.
PMID: 24584005 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Uchida T, Toko K Tags: Yakugaku Zasshi Source Type: research

Kansei biosensors to reproduce gustatory and olfactory senses.
Abstract   Anyone talks about the taste using different taste scale. Since how to feel the taste is different from one to other people, we sometimes lead to inconsistency when speaking about the taste of food. The present study aims at development of electronic tongue (taste sensor) and electronic nose (odor sensor). There are two important properties about the taste sensor. One, each sensor electrode (lipid/polymer membrane) is specific to each taste. Another is that the sensor can measure the aftertaste such as richness, which is the aftertaste of umami. In the case of, e.g., bitterness electrode (BT0), it resp...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Toko K Tags: Yakugaku Zasshi Source Type: research

Development of taste sensor for bitterness evaluation of drugs.
Abstract   In pharmaceutical fields, the palatability of drug formulation has been attracted, especially for children. It is excellent that pediatric medicines are delivered to a famine-stricken area on volunteer work. However, children cannot take extremely bitter drug because they are said to be highly sensitive to bitterness. Therefore, we contribute to the development of formulation palatable to children by providing pharmaceutical industry with "the measure of taste". In taste sensing technology, we established two methods to control the sensor's characteristics by optimizing both electric density and hydrop...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Ikezaki H Tags: Yakugaku Zasshi Source Type: research

Comprehensive evaluation of palatability for commercial medicine by taste sensing system.
Abstract   The bitterness of 10 basic medicines was evaluated using a multichannel taste sensor (Intelligent Sensor Technology). Three variables were obtained from the taste sensor data: sensor output (S), the change of membrane potential caused by adsorption, corresponding to aftertaste (C), and the ratio C/S. These variables were used to predict an estimated bitterness score in multiple regression analysis. There was correlation between the bitterness score predicted by the taste sensor and the score obtained by human gustatory sensation. The method showed quantitative predictability for the evaluation of bitte...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Uchida T Tags: Yakugaku Zasshi Source Type: research

Application of taste sensor to medicines in research, development and market.
Abstract   Using a taste sensor in the field of medical products has the following four main purposes: (1) Ensuring that investigational product and placebo are indistinguishable; (2) Formulation design; (3) Quality control; (4) Benchmark test. Unlike evaluating a taste of food, roughly predicting a taste of drug without human sensory test and quantitative evaluation using small quantity of drug sample are more important than evaluation of the nuances of homogeneous taste and preference. Here are some examples of using taste sensor for these purposes. (1) We predicted a taste of suspension of phosphatic drug subs...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Harada T, Sakurai M, Hondo S, Yasui M, Owaki T Tags: Yakugaku Zasshi Source Type: research

Odor sensing system and olfactory display.
In conclusion, both odor sensing system and olfactory display can contribute to the field of human health care. PMID: 24584010 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Nakamoto T Tags: Yakugaku Zasshi Source Type: research

The Introduction of Medical Product's Applications by Using Flavor and Fragrance Analyzer "FF-2020".
Abstract   The design concept of flavor and fragrance analyzer "FF-2020" was descried; at first how to recognize the quantification of odor, introducing traditional quantification of odor and how to compose the analyzer. At last two analysis of the medical goods were described. The most important thing to quantify the odor is to recognize the three faced of odor that is chemical component face, subjective feeling and objective feeling. For the electronic nose like a flavor and fragrance analyzer, objective feeling should be quantified by the analyzer. Then the original mode of analysis was made to realize the qua...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Kita J Tags: Yakugaku Zasshi Source Type: research

Academic Detailing-Evidence-based Approach for the Proper Use of Medicines.
PMID: 24584012 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Yamamoto M, Orii T Tags: Yakugaku Zasshi Source Type: research

Drug information for safe use.
Abstract   Various information on pharmaceuticals is provided to healthcare professionals in order to ensure the safe use of pharmaceuticals. In addition to package inserts that contain information on indication, dosage, and administration, some review reports of new drugs which contain the summary of the results of clinical trials submitted for new drug application and review process as well as manuals for handling disorders due to adverse drug reactions which contain early symptoms and information on treatment of serious adverse reactions are provided. Information on drugs is renewed based on drug reactions rep...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Watanabe S Tags: Yakugaku Zasshi Source Type: research

Academic detailing for best practice and pharmacists' role.
Abstract   It is necessary to offer the proper information about prescription drugs for appropriate use of them in clinical practice. However, a lot of time and labor is required to comprehensively collect the information necessary for clinical application and it could be extremely difficult. If the clinical experience and other information is derived solely on a commercial basis, then it may lead to improper prescription practices. "Academic detailing" is a form of interactive educational outreach to physicians to provide unbiased, non-commercial, evidence-based information about medications and other therapeuti...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Yamamoto M Tags: Yakugaku Zasshi Source Type: research

Approach to academic detailing as a hospital pharmacist.
Abstract   In 2012, a new medical fee system was introduced for the clinical activities of hospital pharmacists responsible for in-patient pharmacotherapy monitoring in medical institutions in Japan. The new medical system demands greater efforts to provide the most suitable and safest medicine for each patient. By applying the concept of academic detailing to clinical pharmacists' roles in hospitals, I present drug use evaluation in three disease states (peptic ulcer, insomnia, and osteoporosis). To analyze these from multiple aspects, we not only need knowledge of drug monographs (clinical and adverse drug effe...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Nishikori A Tags: Yakugaku Zasshi Source Type: research

Expects for Academic Detailing from the Standpoints of Evidence-based Medicine (EBM).
Abstract   Academic detailing, interactive information services by pharmacists for clinicians, has been getting interests in the US and European countries. A systematic review of randomized controlled trials supported the effectiveness of academic detailing. Knowledge of evidence-based medicine and clinical practice guidelines is one of the essential bases for pharmacists to promote these activities. In addition, pharmacists need to understand attitudes and ways of thinking of clinicians toward medicines. Through communications and information sharing between clinicians and pharmacists, collaborations to modify a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Nakayama T Tags: Yakugaku Zasshi Source Type: research

Elucidation of the pathogenesis of chronic and intractable pain and its drug discovery.
PMID: 24584017 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Tokuyama S, Maeda T Tags: Yakugaku Zasshi Source Type: research

Study on Novel Mechanism Underlying Analgesia Targeting TRPV1.
Abstract   Transient receptor potential protein (TRP) channels are distributed in pain pathways including primary afferent neurons and function as transduction of various noxious stimuli to innocuous stimuli. TRP channels are considered as molecular basis of chronic pain. Targeting TRPs may lead to novel class of analgesics, and so drug-discovery efforts are focused on TRP agonists and its antagonists. Few products have, however, been placed on the market, because most of candidates have adverse effects. A lesion or disease of the somatosensory nervous system causes neuropathic pain, a type of chronic pain. Neuro...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Maeda T, Ozaki M Tags: Yakugaku Zasshi Source Type: research

Roles of transient receptor potential melastatin 2 expressed on immune cells in neuropathic pain.
In this study, we examined the roles of TRPM2 expressed on immune and glial cells in neuropathic pain. TRPM2 deficiency attenuated pain behaviors (mechanical allodynia, thermal hyperalgesia and spontaneous pain behaviors) in various kinds of inflammatory and neuropathic pain, but not in nociceptive pain models. In peripheral nerve injury-induced neuropathic pain models, TRPM2 deficiency diminished infiltration of neutrophils mediated through CXCL2 production from macrophages around the injured peripheral nerve and activation of spinal microglia, suggesting that TRPM2 expressed on macrophages and microglia aggravates periph...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Nakagawa T, Isami K, Haraguchi K, So K, Asakura K, Shirakawa H, Kaneko S Tags: Yakugaku Zasshi Source Type: research

Contribution of the sensitization of supraspinal nociceptive transmission in chronic pain.
Abstract   Central sensitization in the spinal cord is well known to be involved in chronic pain. Recent investigations indicated that the protein expressions involving the synaptic plasticity are changed in several brain areas under a chronic pain condition. These changes in supraspinal neural function might cause the emotional and memory dysfunction. It is also possible that these changes are involved in the chronic pain. Indeed, since the improvement of spinal and peripheral sensitization showed limited relief in the neuropathic pain, the sensitization of supraspinal nociceptive transmission might be involved ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Ohsawa M, Yamamoto S, Ono H Tags: Yakugaku Zasshi Source Type: research

Antinociceptive Effect of Docosahexaenoic Acid (DHA) through Long Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40).
Abstract   Fatty acids, one class of essential nutrients for humans, are an important source of energy and an essential component of cell membranes. They also function as signal transduction molecules in a variety of biological phenomena. The important functional role of fatty acids in both onset and suppression of pain has become increasingly apparent in recent years. Recently, we have also demonstrated that the release of an endogenous opioid peptide, β-endorphin, plays an important role in the induction of docosahexaenoic acid (DHA)-induced antinociception. It is well known that fatty acids affect intracellul...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Nakamoto K, Nishinaka T, Sato N, Mankura M, Koyama Y, Tokuyama S Tags: Yakugaku Zasshi Source Type: research

Electrophysiological evaluation of pathophysiological and pharmacological characteristics of chronic pain.
Abstract   Recent studies have revealed considerable evidence for our understanding of the mechanisms underlying the development and maintenance of chronic pain including neuropathic and inflammatory pain. It is considered that plastic changes in the spinal dorsal horn contribute to the amplification of pain signaling. Moreover, persistent pain affects brain function and also the endogenous descending pain regulatory system. To characterize these pathophysiological changes and pharmacological properties in chronic pain conditions at the synaptic level, we have employed in vitro electrophysiology in slices of the ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Tanabe M Tags: Yakugaku Zasshi Source Type: research

Pharmaceutical analysis of chemicals related with daily life products for safe and secure.
Abstract   An association between exposure to trace hazardous chemicals such as endocrine disrupting chemicals and an increased incidence of human endocrine disease might be continued to study. The accurate and sensitive analytical methods for determination of various chemicals in human biospecimen such as urine, blood and breast milk have been studied by techniques including chromatography. In order to obtain the safe and secure life, the pharmaceutical analytical approaches might be applicable with the hopes of realizing scientific risk assessment of the chemicals derived from daily life products as regulatory ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Nakazawa H Tags: Yakugaku Zasshi Source Type: research

Development of a novel transdermal delivery system of alendronate, a nitrogen containing bisphosphonate, using a new type of hydrophilic patch and dissolving microneedle arrays.
Abstract   Alendronate is a nitrogen-containing bisphosphonate that is widely used for the treatment of osteoporosis in postmenopausal women. However, the oral bioavailability (BA) of alendronate is approximately 0.9 to 1.8%. In addition, the oral administration of alendronate has been associated with mucosal damage including gastritis, gastric ulcer, and erosive esophagitis. To prevent these adverse effects of alendronate, patients with osteoporosis should sit up or walk for more than 30 min after oral administration, leading to poor compliance and QOL in these patients. To improve the compliance and QOL of thes...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Katsumi H Tags: Yakugaku Zasshi Source Type: research

Relationship between the Effectiveness and Dose of Micafungin in the Treatment of Candidemia.
Abstract   The Guidelines for Management of Deep-seated Mycoses 2007 recommend the use of micafungin as a first-line agent for the treatment of candidemia. On the package insert, the recommended dose of micafungin is 50 mg/d. However, the Guidelines recommend a micafungin dose of 100-150 mg/d. In the present study, we evaluated the relationship between the effectiveness and dose of micafungin in 42 patients with candidemia who underwent treatment with micafungin. We found that the efficacy rate of micafungin at a dose of 50 mg/d was 40%, whereas that at ≥100 mg/d was 87.5%. Moreover, the treatment was more effe...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Sugawara T, Murakami N, Uetake N, Matsumoto S, Miyamori S, Okamoto R, Hiraki K Tags: Yakugaku Zasshi Source Type: research

Errata: Z-ligustilide Extracted from Radix Angelica Sinensis Decreased Platelet Aggregation Induced by ADP Ex Vivo and Arterio-venous Shunt Thrombosis In Vivo in Rats.
PMID: 24584026 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Zhang L, DU JR, Wang J, Yu DK, Chen YS, He Y, Wang CY Tags: Yakugaku Zasshi Source Type: research

Progress for the revival after the fukushima nuclear plant accident to date.
PMID: 24492212 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Kojima S, Inoue H Tags: Yakugaku Zasshi Source Type: research

Assessment and Control of Health Risk Caused by the Radiological Accident at the TEPCO Fukushima Daiichi Nuclear Power Plant.
Abstract   The accident at the Tokyo Electric Power Company (TEPCO) Fukushima Daiichi nuclear power plant on March 11, 2011, released a large amount of radioactive materials resulting in the radioactive contamination of a wide area of eastern Japan. Residents of the Fukushima prefecture experienced various unavoidable damages and fear of radiation effects on their health. A reliable communication of accurate risk assessment for residents is required as a countermeasure aimed at the reconstruction of Fukushima. Here, the current status of individual dose estimation and the issues relating to the radiation risk per...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Matsuda N, Morita N, Miura M Tags: Yakugaku Zasshi Source Type: research

The terrestrial environmental dynamics of radioactive nuclides released by the fukushima nuclear accident.
Abstract   Research into environmental dynamics of radioactive nuclides released by the Fukushima nuclear accident, especially radiocesium (137)Cs (half-life, 30.1 years), is highly focused especially on diffusion processes of radiocesium into ecosystems, which is high-priority knowledge. Because of relatively sparse knowledge about the reallocation of radiocesium contained in organic matter in terrestrial ecosystems, the effects of diffused rediocesium into ecosystem cannot be accurately estimated. In this article, the terrestrial environmental dynamics of radiocesium mainly in the processes of plant uptake and ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Furukawa J Tags: Yakugaku Zasshi Source Type: research

Transport processes of fukushima derived radioactivity in the pacific ocean.
Abstract   Before the Fukushima Nuclear Power Plant 1 (FNPP1) accident, environmental (137)Cs was already detectable originating from nuclear weapon tests conducted in the late 1950s and early 1960s. In the western North Pacific Ocean, (90)Sr and (137)Cs activities in surface water were 10-100 Bqm(-3) in the late 1950s and early 1960s, then this parameter decreased gradually; (137)Cs activity in surface water subsequently decreased to around a few Bq m(-3). After the FNPP1 accident, (137)Cs and (134)Cs were released into the North Pacific Ocean by two pathways, direct discharge from the Fukushima NPP1 accident si...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Aoyama M Tags: Yakugaku Zasshi Source Type: research

Effect of ionizing radiation on the living body.
Abstract   Since the Fukushima nuclear plant accident following the great East Japan earthquake on March 11, 2011, we have been warned to be careful about possible radiation exposure almost every day in newspapers and on TV. Radioactive iodine ((131)I) and cesium ((134)Cs, (137)Cs) produced by nuclear reactions were released into the air during and after the accident, and have been scattered by the winds in Tohoku and in the Kanto district. Even today, 2 years after the accident, there is great public concern about possible pollution of foodstuffs and fishery products with radioactive cesium, not only in Japan, b...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Kojima S Tags: Yakugaku Zasshi Source Type: research

What should the radiation education in Japan in the future be like?
Abstract   In respect to policy and involvement in social cognition of Advanced Science and Technology, people desire to recognize the scientific understanding and social understanding hierarchically and simultaneously. However, the understandings of some sciences and technologies are dependent on the amount of information given and how easy it is to understand it. Nuclear power and radiation are a typical example of such sciences and technologies because their advantages and disadvantages are clear. On the other hand, the Fukushima Nuclear Plant Accident that occurred in March 2011 caused the myth about the safe...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Inoue H Tags: Yakugaku Zasshi Source Type: research

Team-based Learning (TBL) Brings Active and Complementary Learning-Practice and Outcomes in Pharmacy Education.
PMID: 24492218 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Yasuhara T, Kosano H Tags: Yakugaku Zasshi Source Type: research

Team-based Learning (TBL) in the Interdisciplinary Lecture.
Abstract   We conducted team-based learning (TBL) with interdisciplinary lectures as a part of "Introduction to Pharmacy", divided among the pharmacy department's six pharmacist education curricula in the first semester. The interdisciplinary lecture is led by seven lecturers, each specializing in one area: cell biology, biochemistry, chemistry, public health pharmacology, pharmacokinetics, and clinical science. This lecture's purpose is to demonstrate to the students that all field subjects relate to each other and they must learn the basic science subjects to understand pharmaceutical sciences. The TBL contents...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Nishiwaki K, Kawase A, Wada T, Yagi H, Kawasaki N, Ito E, Iwaki M Tags: Yakugaku Zasshi Source Type: research

Introduction of Team-based Learning to the Pharmacy Experiential Practice Course for First-year Pharmacy Students.
Abstract   In recent years, the number of high school graduates has decreased, whereas the number of new pharmacy schools has increased substantially. Therefore, pharmacy schools these days accommodate students from diverse backgrounds in terms of basic knowledge, study skills, and/or their motivation to be pharmacists. To address this issue, we developed a mandatory 10-day course named "Pharmacy experiential practice" for the first-year students. The program trains students in basic pharmacy calculation skills and communication skills, and provides an insight into how these skills can be applied in actual pharma...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Norose T, Ito M, Endo K, Fujimoto T, Moriya H, Murakami M Tags: Yakugaku Zasshi Source Type: research

Practical Chemistry Education Provided by Team-based Learning (TBL) and Peer Evaluation.
In this study, we researched the adoption of a peer evaluation process for this participatory learning model. Questionnaires taken after TBL exercises in the previous year showed a positive response to TBL. Further, a questionnaire taken after TBL exercises in the spring semester of the current year also yielded a positive response not only to TBL but also to peer evaluation. In addition, a significant correlation was observed between the improvement of students' grades in chemistry classes and the feeling the percentage (20%) of peer evaluation in overall evaluation low (logistic regression analysis, p=0.022). On the basi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Yasuhara T, Konishi M, Nishida T, Kushihata T, Sone T, Kurio W, Yamamoto Y, Nishikawa T, Yanada K, Nakamura M Tags: Yakugaku Zasshi Source Type: research

Front line of combating counterfeit medicines, globally and locally.
PMID: 24492222 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 12, 2014 Category: Drugs & Pharmacology Authors: Kimura K Tags: Yakugaku Zasshi Source Type: research