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Necessity of Advance Pharmaceutical Education and Research for Upbringing of the Pharmacist Who Can Make a Immediate Decision in Patient's Problems.
PMID: 25747205 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ooi K, Takamura N Tags: Yakugaku Zasshi Source Type: research

The necessity for pharmaceutical education on perioperative care-considering the activities of operating room pharmacists in relation to types of anesthetic operations involved.
Abstract   In an effort better to understand the application of pharmaceutical services in the operating room (OR) we conducted a survey among OR department directors of 526 hospitals throughout Japan. A total of 202 directors responded to the survey. Pharmacists are expected to achieve better outcomes in pharmacotherapy as well as play major roles as members of diverse perioperative care teams. Besides implementing medication safety standards, pharmacists' roles include optimizing drug therapy and other clinical interventions, both in OR and wards. Presently, few pharmacists in Japan participate in perioperative...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Shibata Y, Kawamoto M, Kihira K Tags: Yakugaku Zasshi Source Type: research

Practice of drug monitoring based on comprehensive pharmaceutical judgment.
Abstract   With the revisions to the pay for performance of pharmaceutical service of inpatients in April 2012, the ward permanent time of pharmacists grew longer than previously; however, there are as yet few reports on the pharmaceutical outcome of the new medical service. To improve the pharmaceutical service requires that pharmacists collect useful medical information and extract the problems of pharmaceutical care for inpatients. Since many cases of treatment with multidrug regimens are regularly performed, pharmacists cannot contribute to medical treatment only by knowledge of a single disease. Therefore qu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Katayama T Tags: Yakugaku Zasshi Source Type: research

Health assessment of local residents who made full use of symptomatology skills and test device.
Abstract   A strategy named "Japan is back" adopted in June 2013 specifies that pharmacies shall be regarded as community-based places where health-related information is provided, and the public shall be encouraged to use the services of pharmacies and pharmacists who can advise on health and appropriate use of over-the-counter (OTC) drugs, and promote self medication. In Japan there are approximately 55000 pharmacies and 260000 pharmacists, and community residents are recommended to use these resources. As advisors on healthcare in the community, pharmacists are required to make judgments regarding drug use in ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Akagawa S, Morikawa N, Ikeda K, Okazaki T, Takahashi S Tags: Yakugaku Zasshi Source Type: research

Key points in clinical pharmaceutical education and research, as seen from pharmaceutical consultation clinics.
Abstract   Pharmaceutical education was expanded to a 6-year system in 2006, in an efforts to enhance clinical pharmaceutical research and education. Since that time, pharmacists have attempted to participate in medical all aspects of medical care, but an environment in which they can master direct pharmaceutical techniques for patients has not yet been sufficiently developed. This is because pharmaceutical education emphasizes the acquisition of knowledge and has not reached the point where it cultivates minds that can adapt to the multitude of situations that are envisaged in medical settings. By incorporating ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ooi K Tags: Yakugaku Zasshi Source Type: research

Necessity of Research of Pharmaceutical Departments in the Creation of New Pharmaceutical Skills through Technical Education of Physical Assessment.
Abstract   Physical assessment skills are now being more widely accepted by pharmacists and pharmaceutical departments than in the past. This is explained by the realization that pharmacists can prevent serious adverse effects and evaluate drug efficacy for their patients through assessment, thus providing effective medical care. However, is that all physical assessment can provide to pharmacists and pharmaceutical students? These students, in turn, should recognize the "need for skill" and the "pleasure to be gained in acquiring that skill" through the physical assessment performed by doctors. They should also r...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Takamura N, Tokunaga J, Ogata K, Setoguchi N Tags: Yakugaku Zasshi Source Type: research

The creation of useful analytical tools to elucidate biological phenomena.
PMID: 25747211 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kishikawa N, Todoroki K Tags: Yakugaku Zasshi Source Type: research

Chemiluminescence assay for the investigation of reactive oxygen species generator.
Abstract   Quinones play critical roles in biological systems, but are also regarded as a class of toxins that can cause oxidative stress in living cells, and the involvement of quinone-based reactive oxygen species in oxidative stress has been reported. In biological systems, quinones are reduced to semiquinone radicals by the enzyme NADPH:quinone reductase. Next, semiquinone radicals react with dissolved oxygen to form superoxide anion, which reacts with biological molecules to cause oxidative stress. On the other hand, chemiluminescence reagents such as luminol can emit chemiluminescence after oxidation by rea...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kishikawa N, Kuroda N Tags: Yakugaku Zasshi Source Type: research

Development and Application of FD-LC-MS/MS Proteomics Analysis Revealing Protein Expression and Biochemical Events in Tissues and Cells.
Abstract   It is routine to search for and recognized genetic defects in human disorders to provide knowledge for diagnosis, treatment, and protection against diseases. It is also important to investigate and demonstrate the cause of a disease from the proteomic perspective, because intracellular signaling systems depend on protein dynamics. Demonstrating changes in protein levels enables us to understand biochemical events during the initiation and progression of a disease. To understand changes in protein levels in tissues and cells, we have developed a novel proteomics approach, FD-LC-MS/ MS. This consists of ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ichibangase T, Imai K Tags: Yakugaku Zasshi Source Type: research

Highly Selective Analysis of Biogenic-related Compounds Utilizing Fluorous Chemistry.
Abstract   Perfluoroalkyl-containing compounds are highly fluorous, meaning that they have a remarkable affinity for one another and effectively exclude non-fluorous species. Utilizing this unique property, we have developed a fluorous derivatization with a liquid chromatographic analysis method for highly selective analysis of target analytes. Although most previous methods focused on extremely sensitive detection-oriented derivatization, the fluorous derivatization method involves highly specific separation for analytes. This method includes perfluoroalkylation of analytes with a fluorous reagent, and separatio...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Hayama T Tags: Yakugaku Zasshi Source Type: research

Development of HPLC analysis methods for therapeutic monoclonal antibodies.
Abstract   Therapeutic monoclonal antibody (mAb) preparations are produced from cultured cells; therefore, detailed and multidimensional analyses of their heterogeneities are required. We analyzed five commercially available mAb preparations by high-temperature reversed-phase LC using a wide-pore core-shell column for pluralistic quality assessment. At a highly elevated column temperature, isopropanol with high eluotropic strength coefficients and a wide-pore core-shell type octyl column showed good peak resolution of the investigated mAbs and their related constituents. We used this method to estimate the residu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Todoroki K Tags: Yakugaku Zasshi Source Type: research

Next Generation Type Formulation Developed Using Innovation to Overcome Trade-offs between Patient-oriented Approach and Clinical Effectiveness of Formulation.
PMID: 25747216 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Uchida T, Namiki N Tags: Yakugaku Zasshi Source Type: research

Trade-offs in the Development of Various Dosage Form (Overview).
Abstract   In this symposium we focused on trade-offs which might occur in the process of development of many types of formulation and corresponding dissolution methods. Firstly, we focused on a solubility-permeability trade-off in the case of micelle with surfactant or molecular complex with CyD. The micelle would be successful in increasing drug solubility, however it rather decreased permeability of model drug progesterone (Biopharmaceutics Classfication System (BCS) Class II) as an overall flux. Secondly in order to reduce bitterness of branched chain amino acid (BCAA), increasing particle sizes of each amino...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Uchida T Tags: Yakugaku Zasshi Source Type: research

Trade-offs in Oral Drug Product Development.
This article introduces examples of such innovations which have been successful in doing this, as well as some encountered in the oral formulation development and in the selection of proper dosage forms. Based on these examples, points to be considered in order to produce the drug product are thoroughly discussed. PMID: 25747218 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kondo H, Sako K Tags: Yakugaku Zasshi Source Type: research

Clinical functionality required for orally disintegrating tablets selected as the next generation type.
Abstract   Orally disintegrating tablets (ODTs) are currently widely used in drug therapy and are clinically attractive, because they are suitable for administration to patients with dysphagia and improve adherence, both of which increase the possibility of achieving the expected therapeutic effect. These properties of ODTs, which increase treatment effectiveness, are termed their "clinical functionality", and ODTs with a high clinical functionality are required to meet the increasing need for these tablets. For example, there is a need for development of a clinically effective ODT with superior disintegrating pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Namiki N Tags: Yakugaku Zasshi Source Type: research

Oral dosage forms for children: acceptability and palatability.
Abstract   Children generally reject taking medicine which does not have a favorable shape, taste, flavor, etc. However, if a child who needs to take a medicine, rejects taking it, he might never recover from his condition. When a child is unable to take medicine orally, it is intravenously administered, and he and his caregivers then may experience stress. Syrups and suspensions are considered as favorable types of dosage forms in which to orally administer medicine to infants and children. However, they may have disadvantages such as solubility, a bad taste, portability problems or required refrigerator storage...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kojima J Tags: Yakugaku Zasshi Source Type: research

Development of a novel oral jelly formulation for elderly patients.
Abstract   Deterioration of the swallowing function in elderly persons and drug refusal among the behavioral abnormalities in Alzheimer's disease (AD) are commonly reported. Therefore, we developed an easy-to-swallow jelly formulation of Donepezil HCl which AD patients can take as a dessert. The development process, however, was full of trade-off problems. (1) Need for evaluating the taste of a drug product vs. Safety of human sensory evaluation of the taste. The trade-off was resolved by using a taste sensor. (2) Speed of development vs. Safety of the manufacturing process. We put priority on the safety rather t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Harada T, Yasuoka K, Sakurai M, Murase T, Owaki T Tags: Yakugaku Zasshi Source Type: research

Development of injection containers for patient and medical staff.
Abstract   Recently, there has been a transition from glass to plastic injection containers in Japan. In our previous study, we suggested that plastic containers had less impurity contamination than glass containers. However, the use of some plasticizers has been limited because of their endocrine disrupting effects. Therefore, contamination has been a concern due to chemicals in injection solution packed with plastic containers. Indeed, in our recent study, photoinitiators were detected in an injection solution coming from plastic containers. Photoinitiators mainly exist in ink. We therefore speculated that ink ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kawasaki Y, Sendo T Tags: Yakugaku Zasshi Source Type: research

The role of formulation and dosage form in vaccine.
Abstract   The importance of vaccination has recently been widely recognized among Japanese people with a growing interest in vaccine. On the other hand, because vaccine is administrated to healthy people, it has had a difficult history due to overreaction to adverse events. With the recent rapid increase in the rate of vaccination, however, it is essential to correct the understanding of the public as to the risk and benefit of vaccine. Life spans around the world and infectious diseases are closely related, and vaccine certainly contributes to the control of the latter. Research and Development (R&D) of nov...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kikuchi M Tags: Yakugaku Zasshi Source Type: research

What is proper drug information for patients to minimize risk?∼constructing drug guide for patients∼.
PMID: 25747224 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Yamamoto M, Sugimori H Tags: Yakugaku Zasshi Source Type: research

Present state and future tasks of "drug guide for patients".
Abstract   Safety information on drugs is provided through package inserts, which are the most basic tool offered by pharmaceutical companies, "Emergency Safety Information" and "Pharmaceuticals and Medical Devices Safety Information", etc. issued by the Ministry of Health, Labour and Welfare (MHLW). In addition, the Pharmaceuticals and Medical Devices Agency (PMDA) recently established an information website, and the provision of enhanced information is now being promoted not only for health care professionals but also for patients. "Drug Guide for Patients" is one of the information tools for patients. The "Dru...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Isozaki M Tags: Yakugaku Zasshi Source Type: research

Drug Information for Patients (Package Leaflets), and User Testing in EU.
Abstract   Patients and consumers have desired high quality drug information in their pharmacotherapy, and are entitled to receive it. It is desirable that the information should be aimed at shared decision-making between patients and healthcare professionals about medications. The quality of drug information available to patients should also be assured. With an aim to improve the quality of "Drug Guide for Patients", we investigated Patient Information Leaflets (PILs) which are approved by the Medicines and Healthcare Products Regulatory Agency (MHRA) in the United Kingdom (UK) with regard to the criteria of dev...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Yamamoto M, Doi H, Furukawa A Tags: Yakugaku Zasshi Source Type: research

Review of drug information provided to patients from the viewpoint of hospital pharmacists.
Abstract   Risks for patients and consumers can be minimized depending on how they are provided appropriate drug information. Therefore, from the viewpoint of hospital pharmacists, I would like to report on how information should be provided in order to minimize patient risk. For example, there is an ongoing opinion that the provision of easy-to-understand drug information to patients and consumers "does not appear necessary". The reasons for this include the following: Because the level of understanding varies greatly among patients, it is difficult to define what "easy-to-understand" information entails; rather...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Orii T Tags: Yakugaku Zasshi Source Type: research

Findings from a questionnaire survey on new guidelines for preparing drug guide for patients and a perspective from a pharmaceutical company as the information provider.
Abstract   Draft versions of two products of based on a "Drug Guide for Patients" have been prepared the guidelines proposed in "Research on risk communication between patients and healthcare professionals regarding information on safety measures for drugs, etc." by Health and Labour Sciences Research Grants. We conducted a questionnaire survey on the draft to identify issues regarding the contents and their preparation from the viewpoint of pharmaceutical companies as authors. The questionnaire results indicated that, the segments of the contents of the "Drug Guide for Patients" based on the new guidelines are g...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Asada K Tags: Yakugaku Zasshi Source Type: research

What is a medication guide suits patients' needs?
Abstract   In order for a patient to read a medication guide and develop appropriate behavior regarding use of the medication, the guide should suit patients' needs. In medical care, the primary needs of patients are preventing/curing disease and/or relieving symptoms. Certainly, patients would like knowledge about what can be expected after taking a medication. However, current "Drug Guides for Patients" are based on drug labeling, which is essentially a medically sophisticated instruction manual for medical professionals who have existing knowledge about the medical treatment of the disease. Thus, there seems t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Sato T Tags: Yakugaku Zasshi Source Type: research

Development of metallomics research on environmental toxicology.
Abstract   Metallomics is newly coined terms and defined as a comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type. Then, metallome is defined as the entire category of metalloproteins and any other metal-containing biomolecules. Metallomics and research on metallome require analytical techniques that can provide information on the identification and quantification of metal/metalloid-containing biomolecules. This concept has been called speciation, and the acquisition of data according to the concept is performed using hyphenated techniques involving both separation a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ogra Y Tags: Yakugaku Zasshi Source Type: research

Pharmacokinetics characteristics of dexamethasone in crush syndrome model rats.
Abstract   Crush syndrome (CS) is characterized by ischemia/reperfusion-induced rhabdomyolysis and subsequent systemic inflammation and has a high mortality rate, even when treated with conventional therapy. In previous studies, we demonstrated that treatment of rats with acute lethal CS using dexamethasone (DEX) had therapeutic effects in laboratory findings and improved the clinical course of CS. However, because the application of DEX in CS therapy is unknown, evaluation of the pharmacokinetic parameters of DEX was considered essential to support its clinical use. Here, we investigated the pharmacokinetic char...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Murata I, Otsuka A, Hara C, Motohashi R, Kouno S, Inoue Y, Kanamoto I Tags: Yakugaku Zasshi Source Type: research

Fundamental Study of Memory Impairment and Non-cognitive Behavioral Alterations in APPswe/PS1dE9 Mice.
Abstract   In addition to cognitive decline, Alzheimer's disease patients also exhibit non-cognitive symptoms commonly referred to as behavioral and psychological symptoms of dementia, or BPSD. These symptoms have a serious impact on the quality of life of these patients, as well as that of their caregivers, but there are currently no effective therapies. The amyloid β-peptide (Aβ) is suspected to play a central role in the cascade leading to Alzheimer's disease, but the precise mechanisms are still incompletely known. To assess the influence of Aβ pathology on cognitive and non-cognitive behaviors, we examine...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Taniuchi N, Niidome T, Sugimoto H Tags: Yakugaku Zasshi Source Type: research

Learning Outcomes of Six-year Pharmaceutical Education Program.
PMID: 25759036 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Nakamura A, Hasegawa Y, Kamei M Tags: Yakugaku Zasshi Source Type: research

Outcome of the 6-year curriculum for pharmacy education: "contribution to medical care and society: how will I act as a pharmacist in the future?"-a report on the 3rd national student workshop.
Abstract   In August 2013, the Pharmaceutical Society of Japan held the Third National Student Workshop in Tokyo. A total of 88 people-70 sixth-year undergraduate students from 70 universities, and 18 alumni who had participated in the First and the Second Workshops-attended this Workshop. The theme of this Workshop was "Contribution to medical care and society: How will I act as a pharmacist in the future?" The first day took the form of a World Café, with participants exchanging information on such topics as, "The purpose for choosing a pharmacy major, and my achievement status", "My favorite aspects of my col...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kamei M, Imoto Y, Otowa R, Shida M, Hirai Y, Nakamura A Tags: Yakugaku Zasshi Source Type: research

Introduction of Outcome-based Education in Pharmaceutical Education in Japan.
Abstract   Although Japanese medical and pharmaceutical educators have been interested in outcome-based education (OBE) in recent years, there are still many difficulties and problematic concepts involved in curriculum building, especially in determining objectives and assessment methods. From 2015, OBE will be incorporated in a model core curriculum of pharmaceutical education in Japan. In this paper, we will introduce the outline of an operative sample of OBE derived from the National Competency Standards Framework for Pharmacists in Australia. The products shown in this paper are examples of standards, element...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Takahashi H, Kosano H Tags: Yakugaku Zasshi Source Type: research

Design of spiral curriculum for pharmacy students to reach the outcome.
Abstract   The third advanced workshop of the Pharmaceutical Society of Japan for pharmaceutical teachers was held from October 12th to 14th, 2013, and participants discussed an outcome-based approach to curriculum development in pharmacy education. In this article, I report the outcome-based spiral curriculum model of group 2A, which was designed to enable pharmacy students to understand a patient's condition, and to provide a basic practical ability in medical therapy. In the curriculum, pharmacy students will learn biochemistry and functional morphology in the first and second years, skills to interview patien...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Sato E Tags: Yakugaku Zasshi Source Type: research

Program to Learn about the Empowerment: Diabetic Theater, a Workshop Including Drama and Discussion.
Discussion. Yakugaku Zasshi. 2015;135(3):349-50 Authors: Okada H PMID: 25759040 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Okada H Tags: Yakugaku Zasshi Source Type: research

"Throw your hammer!" the essence of patient empowerment in diabetes.
Abstract   The empowerment approach to patients with diabetes is a philosophy that was introduced by Robert M. Anderson and Martha M. Funnell of Michigan Diabetes Research and Training Center in the 1990s. This approach is based on the observation that more than 98% of diabetes care is performed by patients themselves. Dr. Anderson, Ms. Funnell, and their colleagues found that every patient has a right and an ability to solve his/her own problem in his/her own diabetes. Therefore healthcare providers should provide support for patients own endeavors. Empowerment has three essential elements: 1) the patient is cen...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Okazaki K Tags: Yakugaku Zasshi Source Type: research

Diabetes theater in kumamoto: scenario of the diabetes theater and contents of discussion.
Abstract   Diabetes Theater (DT) is reenactment of pharmacists treating their patients during medical interviews. DT shows different pharmacists treating their patients using different methods. After the performance, the participants can learn from reflecting on the plays and their own work. At the 134th Annual Meeting of the Pharmaceutical Society of Japan, Kumamoto we performed 3 plays. The plays were about a diabetic patient with hypoglycemia who consults 3 pharmacists who have 3 different approaches. Clinical pharmacists in Kumamoto performed and created DT. After DT, we received responses for each play from ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Nishimura H, Okada H Tags: Yakugaku Zasshi Source Type: research

Evaluation of diabetes theater: results of questionnaire survey and discussion.
In conclusion, DT was well accepted by attendances as a unique program to learn effective patient communication skills and thereby achieve better patient-pharmacist relations. Our findings suggest that DT might be an interesting approach to improve attitudes of pharmacists in diabetes care with the aim of empowerment. PMID: 25759043 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Okada H Tags: Yakugaku Zasshi Source Type: research

In what ways can we expand on empowerment to pharmacists?
Abstract   The number of Japanese patients with chronic diseases is increasing year by year largely because of the acceleration of demographic aging and lifestyle changes in Japan. Although many patients with chronic diseases receive their medications from pharmacists, many community pharmacists have not changed their communication style with their patients. Empowerment is the basic idea that patient support is not widely known by pharmacists but the certified diabetes educator (CDE). We started Diabetes Theater, a program for healthcare providers that includes short drama and discussion with attendees, in 2009. ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Okada H Tags: Yakugaku Zasshi Source Type: research

Chemical biology for pharmaceutical science-integrative approaches for elucidation of biological phenomena.
PMID: 25759045 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Nakase I, Nomura W Tags: Yakugaku Zasshi Source Type: research

Creation of Artificial Receptors Activated by Coiled-coil Peptides and Cellular Regulation.
Abstract   Exploiting the ability of coiled-coil peptides to induce dimer formation, we designed an artificial epidermal growth factor receptor (EGFR) in which dimerization is essential for increasing the tyrosine kinase activity of its intracellular domain. Using leucine-zipper coiled-coil peptides, the surface-exposed E3 ((EIAALEK)3) tag sequence was fused with EGFR (E3-EGFR) lacking domains I-III and a part of IV, which participate in dimerization of EGFR after binding to natural ligand (that is, epidermal growth factor). To dimerize E3-EGFR we synthesized conjugates of two K4 ((KIAALKE)4) peptides, called K4-...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Nakase I Tags: Yakugaku Zasshi Source Type: research

Total Synthesis of Biologically Active Alkaloids Using Bio-inspired Indole Oxidation.
Abstract   Many tryptophan-based dimeric diketopiperazine (DKP) alkaloids including WIN 64821 and ditryptophenaline, which exhibit fascinating biological activities, have been isolated from fungi. These alkaloids possess a unique architecture; therefore several total syntheses of these compounds have been accomplished via bio-inspired reactions. Despite these elegant strategies, we were convinced that a more direct bio-inspired solution for the preparation of tryptophan-based DKP alkaloids was possible because in a true biosynthesis, direct dimerization of tryptophan occurs in aqueous media without incorporation ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ishikawa H Tags: Yakugaku Zasshi Source Type: research

Non-invasive Analysis of Proteins in Living Cells Using NMR Spectroscopy.
Abstract   NMR spectroscopy enables structural analyses of proteins and has been widely used in the structural biology field in recent decades. NMR spectroscopy can be applied to proteins inside living cells, allowing characterization of their structures and dynamics in intracellular environments. The simplest "in-cell NMR" approach employs bacterial cells; in this approach, live Escherichia coli cells overexpressing a specific protein are subjected to NMR. The cells are grown in an NMR active isotope-enriched medium to ensure that the overexpressed proteins are labeled with the stable isotopes. Thus the obtained...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Tochio H, Murayama S, Inomata K, Morimoto D, Ohno A, Shirakawa M Tags: Yakugaku Zasshi Source Type: research

Synthetic RNA technologies to control functions of Mammalian cells.
Abstract   We recently succeeded in producing nanostructures made of RNA-protein (RNP) complexes. We show that RNA and the ribosomal protein L7Ae can form a triangular-like nanostructure that consists of three L7Ae proteins, which form the apices of the triangle, bound to one RNA scaffold. This shape is created through a 60° kink introduced into the RNA structure on L7Ae binding. By varying the size of the RNA scaffold we could in turn alter the overall size of the triangular nanostructure. Several functions can be added to this nanostructure by the introduction of effector proteins fused to L7Ae. The design and...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Saito H Tags: Yakugaku Zasshi Source Type: research

Application and potential of genome engineering by artificial enzymes.
Abstract   Artificial zinc finger proteins (ZFPs) consist of Cys2-His2-type modules composed of approximately 30 amino acids that adopt a ββα structure and coordinate a zinc ion. ZFPs recognizing specific DNA target sequences can substitute for the binding domains of various DNA-modifying enzymes to create designer nucleases, recombinases, and methylases with programmable sequence specificity. Enzymatic genome editing and modification can be applied to many fields of basic research and medicine. The recent development of new platforms using transcription activator-like effector (TALE) proteins or the clustered...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Nomura W Tags: Yakugaku Zasshi Source Type: research

Development and application of electroanalytical methods in biomedical fields.
Abstract   To summarize our electroanalytical research in the biomedical field over the past 43 years, this review describes studies on specular reflection measurement, redox potential determination, amperometric acid sensing, HPLC with electrochemical detection, and potential oscillation across a liquid membrane. The specular reflection method was used for clarifying the adsorption of neurotransmitters and their related drugs onto a gold electrode and the interaction between dental alloys and compound iodine glycerin. A voltammetric screening test using a redox potential for the antioxidative effect of flavonoid...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kusu F Tags: Yakugaku Zasshi Source Type: research

Study of cytokine signaling: the quest for immunomodulatory drugs interacting with cytokine production and activity.
Abstract   I have been engaged in research and education in the fields of immunology and biochemistry at a medical college and college of pharmacy for 40 years. The original reasons why I began studying cytokines and some of the interests that have motivated me to continue working in the field of cytokine research are described: 1) the roles of cytokines in various immunological and inflammatory diseases (e.g., chemokines in bacterial infections and inflammatory diseases, particularly the role of interleukin-5 and eotaxins in eosinophilia); 2) the role of focal adhesion kinase in antiapoptosis and metastasis of m...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Kasahara T Tags: Yakugaku Zasshi Source Type: research

A new strategy for preventive and functional therapeutic methods for dementia-approach using natural products.
Abstract   Alzheimer's disease (AD) has become a serious social problem in Japan. However, effective preventive and fundamental therapeutic methods for AD have not yet been developed. Using a new strategy in the course of our survey of numerous natural resouces having neurotrophic activity, we isolated a variety of active constituents and proved their pharmacological properties. As a result, we successfully found nobiletin, a compound with anti-dementia activity that comes from citrus peels. Also, we have demonstrated that nobiletin ameliorates cognitive impairment in several dementia model animals such as chroni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Ohizumi Y Tags: Yakugaku Zasshi Source Type: research

Pharmacological Study and Pharmaceutical Intervention to Reduce Intravenous Injection-induced Vascular Injury.
Abstract   Intravenous injection often causes vascular injury such as venous irritation, vascular pain, and phlebitis. Vascular injury deteriorates the patient's QOL and sometimes limits the continuation of injection therapy. Pharmaceutical intervention and pharmacological mechanisms used to reduce vascular injury induced by vinorelbine and epirubicin were reviewed. A multivariate logistic regression analysis revealed that the dose of vinorelbine (≥40 mg) was a significant predictor for venous irritation. Alteration of the volume of normal saline for vinorelbine dissolution, from 50 to 100 mL, significantly dec...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Yamada T Tags: Yakugaku Zasshi Source Type: research

Determinants of the stereoselective pharmacokinetics of fexofenadine.
Abstract   Drug transporters play an important role in the clinical pharmacokinetics of many therapeutic agents. Although it is estimated that about half of all therapeutic agents are chiral, there has been little information on the stereoselective pharmacokinetics related to drug transporters. This review focuses on the drug transporters contributing to the stereoselective pharmacokinetics of fexofenadine enantiomers in humans. Fexofenadine is administered clinically as a racemic mixture, and the plasma concentration of (R)-fexofenadine is about 1.5-fold higher than that of the (S)-enantiomer. Because fexofenadi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Akamine Y Tags: Yakugaku Zasshi Source Type: research

Rab GTPases Networks in Membrane Traffic in Saccharomyces cerevisiae.
Abstract   Intracellular membrane trafficking between membranous compartments is essential for organelle biogenesis, structure, and identity. Rab/Ypt GTPases are well-characterized regulators of intracellular membrane trafficking, functioning as molecular switches that alternate between GTP- and GDP-bound forms. In Saccharomyces cerevisiae, 11 Rab/Ypt GTPases have been identified and their functions are known to be conserved in their mammalian counterparts. In yeast, the secretory pathway is regulated by sequential activation and inactivation (the so-called Rab cascade) of three types of yeast Rab protein -Ypt1p,...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Nagano M, Y Toshima J, Toshima J Tags: Yakugaku Zasshi Source Type: research

Development of a therapeutic agent for menkes disease: solubilization of a copper-disulfiram complex.
Abstract   Menkes disease (MD) is a neurodegenerative disorder characterized by copper deficiency. It is caused by defective intestinal absorption of copper resulting from a deficiency of a copper-transporting ATPase, ATP7A. We investigated the effects of combination therapy with copper and disulfiram, a known lipophilic chelator. We synthesized a copper-disulfiram complex (Cu-DSF) and determined its crystal structure by X-ray crystallographic analysis. Unfortunately, Cu-DSF was not orally bioavailable due to its lipophilicity. We therefore planned to use cyclodextrin as a solubilizing agent to increase the water...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 13, 2015 Category: Drugs & Pharmacology Authors: Hoshi Y, Tani N, Tabata H, Wakamatsu S, Munakata M, Maruyama K, Kodama H, Oshitari T, Natsugari H, Takahashi H Tags: Yakugaku Zasshi Source Type: research