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Nonprescription Drugs and Self-medication-Approach and Practice to Pharmaceutical Education.
PMID: 27374952 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Watanabe K, Ohno N Tags: Yakugaku Zasshi Source Type: research

Non-prescription Drugs and Self-medication: Features and Subjects in Pharmaceutical Education.
Abstract At the time of consultation with a patient regarding OTC drugs, a pharmacist goes through the following five steps. In Step 1 information is collected, including the patient's gender, age, health condition, living situation, etc. In Step 2, upon analyzing and evaluating this collected information, the pharmacist decides whether to recommend that the patient see a medical doctor or whether an OTC drug is sufficient. In Step 3, when an OTC drug is required, the pharmacist suggests the most suitable OTC drug. In Step 4, the pharmacist provides the patient recommendations and information about the selected OTC...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Watanabe K Tags: Yakugaku Zasshi Source Type: research

Primary Care Requirements for Pharmacists-Clinical Reasoning Education at Schools of Pharmaceutical Sciences.
Abstract For appropriate primary care practice corresponding to the various symptoms of a patient, team medicine on that combines the expertise of physicians and other medical staff has been recommended in recent years. It results in (1) higher quality of medical care, (2) lower burden on the physician, (3) better medical safety, and (4) reduced medical expenses. In order to promote team medicine through inter-professional collaboration, the responsibilities of the medical staff need to be reviewed to expand their respective roles. The Ministry of Health, Labour and Welfare designated nine specific medical acts by ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Ashizawa T Tags: Yakugaku Zasshi Source Type: research

Systematic Education of Self-Medication at Tokyo University of Pharmacy and Life Sciences.
Abstract The promotion of self-medication by pharmacies, with the aim of encouraging a patient's self-selection of proper OTC drug, is written about in the national action plan "Japan is Back". The subject of self-medication has been improved in the 2013 revised edition of "Model Core Curriculum for Pharmaceutical Education". At Tokyo University of Pharmacy and Life Sciences, the systematic education of self-medication was started from the onset of the six-year course in the third, fourth and fifth grade. We introduce here a new approach in our systematic education of self-medication. In the practice of the fourth ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Narui K, Samizo K, Inoue M, Watanabe K Tags: Yakugaku Zasshi Source Type: research

Self-medication Activities in a Community Pharmacy for Student Pharmacist Training.
Abstract Japan's Ministry of Health, Labour and Welfare published "the required function and the desired operating form of a pharmacy" and proposed that "a pharmacy should demonstrate a positive role for the promotion of self-medication". In the future, it will be indispensable to pharmacies that pharmacists play a role not only in dispensing medicine but also in serving a central health-station role in the community, including promoting the self-selection of proper OTC medications for the maintenance of health. My pharmacy in a traditional area in Tokyo carries OTC drugs, health and nursing care goods, medical sup...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Sakaguchi M Tags: Yakugaku Zasshi Source Type: research

Issues and Prospects from the OTC Industry vis a vis Pharmaceutical Education and OTC Medicines.
Abstract In the amendment of the Pharmaceutical Affairs Law in 2013, a new category, Pharmacist Intervention Required Medicines (PIRM), was introduced, and other OTC medicines, which were classified after the 2006 amendment, were allowed to be sold via the Internet. Regarding PIRM, Japan's Ministry for Health, Labour and Welfare designates medicines which require special intervention by a pharmacist who explains their proper use to a patient through a face-to-face consultation, wherein the pharmacist provides guidance based on pharmaceutical knowledge and experience. This encourages consumers to approach their long...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Nishizawa M Tags: Yakugaku Zasshi Source Type: research

Possibility of Pharmacist in Emergency Medical Care: To Bring Up a Familiar Pharmacist for Emergency Care by Fusing Clinical Pharmacist Activity and University Education.
PMID: 27374958 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Zamami Y, Koyama T, Nakura H, Enomoto S Tags: Yakugaku Zasshi Source Type: research

Involvement of Pharmacists in Medical Care in Emergency and Critical Care Centers.
Abstract Emergency and critical care centers provide multidisciplinary therapy for critically ill patients by centralizing the expertise and technology of many medical professionals. Because the patients' conditions vary, different drug treatments are administered along with surgery. Therefore, the role of pharmacists is important. Critically ill patients who receive high-level invasive treatment undergo physiological changes differing from their normal condition along with variable therapeutic effects and pharmacokinetics. Pharmacists are responsible for recommending the appropriate drug therapy using their knowle...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Imai T, Yoshida Y Tags: Yakugaku Zasshi Source Type: research

Participation of Pharmacists in Emergency Care at Outpatient Clinics with Multiple Beds.
Abstract A major difference in medical flow between acute and nonacute medical care is the urgency of diagnosis and treatment. In the acute medical setting, diagnosis and treatment sometimes must be done almost simultaneously. Learning clinical management in the acute-care setting can be the basis of drug therapy in other clinical settings. When infusion is performed in emergency medicine, stabilization of blood pH is achieved through kidney and lung functions. At the same time, the oxygen transport capacity is monitored using blood gas analysis. One medical intervention can lead to multiple diagnostic and treatmen...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Deguchi H Tags: Yakugaku Zasshi Source Type: research

Physical Assessment Education Using Various Simulators.
Abstract Pharmacists are in demand not only because of their knowledge of medical therapy but also due to their skills in basic physical assessment and emergency care as medical personnel. Pharmaceutical education has developed using patient simulators in bedside training, seminars in hospital pharmacies, and physical assessment practice at the Kyushu University of Health and Welfare School of Pharmaceutical Sciences. We first explain the outline of the method to confirm basic vital signs with simulators and then demonstrate some simulations to enable the reproduction of drug misadministration/changes in condition....
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Tokunaga J, Takamura N, Ogata K, Setoguchi N, Sato K Tags: Yakugaku Zasshi Source Type: research

Pharmaceutical Education Focused on Pharmacotherapy in Emergency Medical Care.
Abstract Pharmacists are expected to be active members of the healthcare team in emergency medicine, because many pharmaceuticals are administered to patients with life-threatening conditions. However, adequate education for pharmacists and pharmacy students is not provided. The "Emergency Pharmaceutical Sciences" course was introduced for the first time in Japan by the Department of Pharmacy, Okayama University, to offer advanced education in emergency medicine and research related to critical care. We offer an emergency pharmaceutical training program with high-performance simulators and have succeeded in improvi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Zamami Y, Koyama T, Imai T, Takemoto A, Sagara H, Sendo T, Nakura H Tags: Yakugaku Zasshi Source Type: research

Social Pharmacy: Its Performance and Promise.
Abstract Among private Universities of Pharmacy in Japan, Kyoritsu University of Pharmacy was the first to introduce courses in social pharmacy in 1991. Social pharmacy is a discipline driven by social needs. By studying the relationship between pharmacy and society, particularly through case studies, the impact of drugs and changes in societal expectation of them, as well as through historical background studies and surveys of current trends, this discipline acts to determine the roles of pharmacists and pharmacies expected by society. Social pharmacy requires a basic knowledge of pharmaceutical science, but an un...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Fukushima N Tags: Yakugaku Zasshi Source Type: research

Changes in Legal Aspects of Public Education about Drugs and Their Importance.
Abstract Requirements for education on proper use of drugs were included in the junior high school educational guideline in 2012 incorporating pharmaceutical education in the obligatory school curriculum. This move is closely related to the country's new OTC drug marketing system. The amendment of the Pharmaceutical Affairs Law (PAL) in 2013 highlighted the public's own role in "promoting proper use of drugs and other related products and making greater efforts to acquire knowledge and improve understanding of their effective and safe use". Furthermore, the Law to Amend the PAL and Pharmacists Law enforced in 2014 ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Miyamoto N Tags: Yakugaku Zasshi Source Type: research

Molecular Mechanisms of Taste Disorder in Oxaliplatin-administered Rats.
In conclusion, the decreased response to sweet taste by oxaliplatin administration may be due to the upregulation of T1R2 expression. PMID: 27374965 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Nishida K Tags: Yakugaku Zasshi Source Type: research

Protective Efficacy of the Ingestion of Mandarin Orange Containing β-Cryptoxanthin on Lipopolysaccharide-induced Acute Nephritis.
Abstract β-cryptoxanthin is a common carotenoid pigment found in fruit, especially in Satsuma mandarins and in persimmons. After ingestion, β-cryptoxanthin is distributed to and accumulates in organs, such as the liver, lung, and kidney. Recent studies have reported that because of its antioxidant defense, β-cryptoxanthin performs several important functions in the preservation of human health and in the prevention of several diseases, including cancer and osteoporosis. The present study aims to determine whether β-cryptoxanthin has a protective effect on renal glomeruli during acute nephritis. To develop our a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Hikita M, Motojima K, Kamata S, Yoshida T, Tanaka-Nakadate S, Nakadate K Tags: Yakugaku Zasshi Source Type: research

An Attempt to Measure Presentation Skill Acquisition Using Peer and Self-evaluation.
Abstract In six-year pharmacy education programs, humanistic education is now regarded as more important than ever, and we are working to incorporate active learning methods into a variety of subjects. Because performance evaluations are by their nature subjective, it is difficult to ensure the validity of any given assessment. Fifth-year students at Tohoku Pharmaceutical University learn case and prescription analysis in problem-based learning tutorials. As part of this curriculum, 20 presentation and discussion meetings over the course of 10 weeks are held, with approximately 100 students making presentations two...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Morone M, Sato A, Ohno I, Ohkawara Y, Suzuki T, Nakamura H, Azuma Y Tags: Yakugaku Zasshi Source Type: research

Interdisciplinary Subject "Yakugaku Nyumon" for First-year Students Constructed with Lectures and Problem-based Learning.
Abstract In 2013, Kobe Pharmaceutical University established "Yakugaku Nyumon", an interdisciplinary course, which consists of omnibus lectures and problem-based learning (PBL) on topics ranging from basic to clinical subjects. The themes of the PBL were original ones; "Study from package inserts of aspirin", which aimed to reinforce the contents of the interdisciplinary lectures, and "Let's think about aspirin derivatives (super-aspirin)", which aimed to engender an interest in studying pharmacy. The PBL featured questions from teachers to help with study and was therefore referred to as "question-led PBL" (Q-PBL)...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Yamaki K, Ueda M, Ueda K, Emoto N, Mizutani N, Ikeda K, Yagi K, Tanaka M, Habu Y, Nakayama Y, Takeda N, Moriwaki K, Kitagawa S Tags: Yakugaku Zasshi Source Type: research

Association between Selective Beta-adrenergic Drugs and Blood Pressure Elevation: Data Mining of the Japanese Adverse Drug Event Report (JADER) Database.
Abstract Selective beta-adrenergic drugs are used clinically to treat various diseases. Because of imperfect receptor selectivity, beta-adrenergic drugs cause some adverse drug events by stimulating other adrenergic receptors. To examine the association between selective beta-adrenergic drugs and blood pressure elevation, we reviewed the Japanese Adverse Drug Event Reports (JADERs) submitted to the Japan Pharmaceuticals and Medical Devices Agency. We used the Medical Dictionary for Regulatory Activities (MedDRA) Preferred Terms extracted from Standardized MedDRA queries for hypertension to identify events related t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Ohyama K, Inoue M Tags: Yakugaku Zasshi Source Type: research

Lifestyle improvement through continuous measurements of hemoglobin A1c levels and lifestyle checks at the community pharmacy in three cases.
In this study, we took continuous measurements of hemoglobin A1c (HbA1c) levels and conducted lifestyle checks in three cases to determine if these parameters were effective in improving overall wellness. We selected three young men with relatively high HbA1c levels. During the 12-weeks study periods, we regularly measured each participant's HbA1c levels and monitored their lifestyle habits every two weeks at the community pharmacy once every 2 weeks using specific guidelines. The first participant, a 23-year-old man, had a HbA1c level of 5.7% at his first measurement. His HbA1c level decreased to 5.2% at the last measurem...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 28, 2016 Category: Drugs & Pharmacology Authors: Fujita N, Nabetani N, Umemura N, Kikuchi C, Suzuki T Tags: Yakugaku Zasshi Source Type: research

Creation new patient information leaflets with diabetes by pharmacists and assesment conducted by patients.
Abstract  We created a draft of new patient information leaflets to ensure patients' proper use of drugs and to highlight safety issues and improvement plans extracted and proposed by small group discussions (SGD) with pharmacists. A total of 3 SGDs (participants: 15 pharmacists) were conducted with the aim of improving patient information leaflets for oral diabetes drugs. First, the disadvantages and advantages of the current instructions as well as requests for ideal patient information leaflets were obtained from participants.Conventional patient information leaflets that could be improved were useful to under...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 27, 2016 Category: Drugs & Pharmacology Authors: Arai M, Maeda K, Satoh H, Miki A, Sawada Y Tags: Yakugaku Zasshi Source Type: research

Usability of an alcohol disinfectant containing organic acids and metal salt for environmental surfaces.
Abstract   Environmental cleaning and disinfection plays an important role as a part of the standard precautions to prevent healthcare-associated infections, whereas hand hygiene is one of the most important strategies for breaking the chain of transmission. Cleaning and disinfection of high-touch areas in a health-care facility is emphasized. And wiping with an alcohol-saturated cloth which has features such as low corrosion and a wide range of antimicrobial activity is performed commonly for this purpose. Although alcohol provides immediate activity against enveloped viruses, its virucidal activity against cert...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 15, 2016 Category: Drugs & Pharmacology Authors: Okunishi J, Nagahara H, Tsujitani K, Matsuse H, Kugawa K, Soga M Tags: Yakugaku Zasshi Source Type: research

School Pharmacists and Methods of Analysis in Health Science: Pharmaceutical Health Science for the Protection of Children's Health.
PMID: 27252051 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Jinno H, Ueno H Tags: Yakugaku Zasshi Source Type: research

Management for School Environmental Health in Japan.
Abstract Some acts such as the Basic Environment Act are aimed at managing environmental health for a productive living environment in Japan. School is not only a place where lessons for a better future are taught but also an environment in which children spend many hours of their day. Therefore, activities involving regular checks are important to maintain and improve the school environment. Article 5 of the School Health and Safety Act states that schools must make plans and carry out regular checks on school environmental health. Article 6 prescribes that the Minister of Education, Culture, Sports, Science and T...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Kitagaki K Tags: Yakugaku Zasshi Source Type: research

School Pharmacist/School Environmental Hygienic Activities at School Site.
Abstract The "School Health and Safety Act" was enforced in April 2009 in Japan, and "school environmental health standards" were established by the Minister of Education, Culture, Sports, Science and Technology. In Article 24 of the Enforcement Regulations, the duties of the school pharmacist have been clarified; school pharmacists have charged with promoting health activities in schools and carrying out complete and regular checks based on the "school environmental health standards" in order to protect the health of students and staff. In supported of this, the school pharmacist group of Japan Pharmaceutical Asso...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Muramatsu A Tags: Yakugaku Zasshi Source Type: research

School Pharmacist and "Methods of Analysis in Health Science".
The objectives of the "environmental" component of the pharmacy education model core curriculum include performing analyses corresponding to the regularly checked items of the school environmental health standards. Students of the School of Pharmacy should cultivate their expertise in environmental analysis and environmental health, through practices such as sample collection, analysis operation, and evaluation of test results. As analysis experts, school pharmacists must know the principles and characteristics of analytical methods. The "Methods of Analysis in Health Science" published by the Pharmaceutical Society of Jap...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Nagase H Tags: Yakugaku Zasshi Source Type: research

Current Indoor Air Quality in Japan.
Abstract People spend more than two thirds of their daily time indoors. Hence, maintaining a healthy indoor environment is indispensable for the prevention of building related illness. In Japan, guidelines for indoor air quality have been established for 13 volatile/semi-volatile organic compounds (VOCs/SVOCs). These guidelines are now under revision by the Committee on Sick House Syndrome: Indoor Air Pollution. In order to gain information on the current indoor air pollutants and their levels, we carried out a nation-wide survey of VOCs and aldehydes in indoor residential air during 2012-2013. In this review, I co...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Jinno H Tags: Yakugaku Zasshi Source Type: research

Exposure Measurements in Japan Environment and Children's Study.
Abstract The Japan Ministry of the Environment is conducting a large-scale birth cohort study called the Japan Environment and Children's Study (JECS), which involves 100000 mother-child pairs. Mothers are enrolled during pregnancy, and their children are followed up and studied until they reach the age of 13 years. The JECS started recruiting mothers in January 2011 and completed the registration of more than 103000 mothers in March 2014. The National Institute for Environmental Studies takes the lead in the study programming and implementation in cooperation with the National Centre for Child Health and Developme...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Nakayama S Tags: Yakugaku Zasshi Source Type: research

Mechanisms and Pharmacological Strategy Targeting Dysfunction of Endoplasmic Reticulum.
PMID: 27252057 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Ozawa K, Nomura Y, Kitamura Y Tags: Yakugaku Zasshi Source Type: research

Regulation of Unfolded Protein Response via Protein S-nitrosylation.
Abstract Nitric oxide (NO) plays a pivotal function in neurotransmission, vasodilation, proliferation, and apoptosis in various types of cells via protein S-nitrosylation. Previously we demonstrated that protein disulfide isomerase (PDI) is S-nitrosylated in brains manifesting sporadic neurodegenerative diseases. This modification results in dysfunction of its enzymatic activity and consequently the accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER). The aim of this study was to clarify the detailed function of NO on unfolded protein response (UPR) branches. We here found that the ER stre...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Ohkubo Y, Nakato R, Uehara T Tags: Yakugaku Zasshi Source Type: research

Physiological Roles of Ubiquitin Ligases Related to the Endoplasmic Reticulum.
In conclusion, oxidative stress-induced HRD1 insolubilization might be involved in a vicious cycle of increased Aβ production and Aβ-induced oxidative stress in Alzheimer's disease pathogenesis. PMID: 27252059 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Kaneko M Tags: Yakugaku Zasshi Source Type: research

ER Stress-induced Aberrant Neuronal Maturation and Neurodevelopmental Disorders.
Abstract Neurodevelopmental disorders, which include autism spectrum disorder, are congenital impairments in the growth and development of the central nervous system. They are mainly accentuated during infancy and childhood. Autism spectrum disorder may be caused by environmental factors, genomic imprinting of chromosome 15q11-q13 regions, and gene defects such as those in genes encoding neurexin and neuroligin, which are involved in synaptogenesis and synaptic signaling. However, regardless of the many reports on neurodevelopmental disorders, the pathogenic mechanism and treatment of neurodevelopmental disorders r...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Kawada K, Iekumo T, Kaneko M, Nomura Y, Okuma Y Tags: Yakugaku Zasshi Source Type: research

Pathogenic Mechanism of Diabetes Development Due to Dysfunction of Unfolded Protein Response.
Abstract The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and membrane proteins are folded and assembled. Various stresses cause the accumulation of unfolded or misfolded proteins in the ER, resulting in ER dysfunction. This condition is termed ER stress. To cope with ER stress, cells activate a signaling pathway termed the unfolded protein response (UPR). Recently, accumulating evidence suggests that the UPR plays a pivotal role in pancreatic β cells. Pancreatic β cells producing a large amount of insulin are highly sensitive when the UPR is impaired. In mammalian cells, three ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Tsuchiya Y, Saito M, Kohno K Tags: Yakugaku Zasshi Source Type: research

The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome.
Abstract Obesity is one of the major risk factors of metabolic syndrome, such as hypertension, hyperlipidemia, and diabetes. Leptin exerts an anti-obesity effect through the Ob-Rb leptin receptor, which is mainly expressed on hypothalamic neuronal cells. Recent evidence indicated that one of the mechanisms of obesity may be the development of leptin resistance. In the present review, we discuss the mechanisms of leptin resistance in obesity, focusing on endoplasmic reticulum (ER) stress. We previously found that flurbiprofen is a candidate drug for attenuating ER stress and the subsequent development of leptin resi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Hosoi T, Ozawa K Tags: Yakugaku Zasshi Source Type: research

Application of Unfolded Protein Response for Production of Biologics.
Abstract Improvements in the productivity of established mammalian cell lines used for biopharmaceutical production are desirable to increase product yields. Chinese hamster ovary (CHO) cells are the workhorse used for more than 60% of industrial therapeutic antibody production. Glycoprotein secretion by CHO cells requires intracellular processes including transcription, translation, glycosylation, and secretion. Within these intracellular steps, post-translational processes are rate limiting for production in high-producer cell lines. This review focuses on unfolded protein response-based engineering of CHO cells ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Omasa T Tags: Yakugaku Zasshi Source Type: research

Syntheses and Reactions of Chalcogen-containing Heterocycles.
Abstract The advances in my laboratory for the past 20-25 years concerning the chemistry of chalcogen-containing heterocycles are reviewed. The intramolecular cyclization of the chalcogenols (-TeH, -SeH, -SH) into a triple bond or appropriate leaving group produced various chalcogen-containing heterocycles. The reactions of the obtained products were examined: the reactions of 1-benzo- and 2-benzopyrylium salts containing a tellurium or selenium element with several nucleophiles, including alkoxides, amines, the cyanide ion, an active methyl compound (acetone), Grignard reagents, copper reagents, and tin reagents, ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Sashida H Tags: Yakugaku Zasshi Source Type: research

Induction of Aneuploidy, Centrosome Abnormality, Multipolar Spindle, and Multipolar Division in Cultured Mammalian Cells Exposed to an Arsenic Metabolite, Dimethylarsinate.
Abstract Toxicological studies of arsenic compounds were conducted in cultured mammalian cells to investigate the effects of glutathione (GSH) depletion. Dimethylarsinate DMA(V) was not cytotoxic in cells depleted of GSH, but was found to be cytotoxic when GSH was present outside the cells. The results suggested that a reactive form of DMA(V) was generated through interaction with GSH. Dimethylarsine iodide DMI(III) was used as a model compound of DMA(III), and the biological effects were investigated. DMI(III) was about 10000 times more toxic to the cells than DMA(V). Chromosome structural aberrations and numerica...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Ochi T Tags: Yakugaku Zasshi Source Type: research

Reaction Development on π- and σ-Conjugated Bonds and Creation of Innovative Functions.
Abstract Monocarba-closo-dodecaborate (1; [closo-CB11H12](-), or C1-carborane anion) is a symmetrical, stable anionic cluster, which possesses low nucleophilicity/basicity and exhibits three-dimensional aromaticity. In contrast to the rich applications of C2-carborane molecules (C2B10H12), the chemistry of the C1-carborane anion as a platform for functional molecules has not been thoroughly studied thus far due to the lack of its efficient functionalization. In particular, no efficient general methods are available for the introduction of aryl and sp(2)/sp-carbon groups at the carbon vertex of the C1-carborane anio...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Takita R Tags: Yakugaku Zasshi Source Type: research

Animal Models for Elucidation of the Mechanisms of Neuropsychiatric Disorders Induced by Sleep and Dietary Habits.
Abstract Numerous changes in human lifestyle in modern life increase the risk of disease. Especially, modern sleep and dietary habits are crucial factors affecting lifestyle disease. In terms of sleep, decreases in total sleep time and in rapid eye movement sleep time have been observed in attention-deficit/hyperactivity disorder (ADHD) patients. From a dietary perspective, mastication during eating has several good effects on systemic, mental, and physical functions of the body. However, few animal experiments have addressed the influence of this decline in sleep duration or of long-term powdered diet feeding on p...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Yaoita F Tags: Yakugaku Zasshi Source Type: research

Pharmacokinetic and Pharmacodynamic Analyses of Drug-Drug Interactions between Iguratimod and Warfarin.
Abstract Iguratimod (IGU), a disease-modifying antirheumatic drug launched in September 2012, has been reported to carry a risk of severe hemorrhages through a suspected interaction with warfarin (WF) in the all-case surveillance and early postmarketing-phase vigilance. To elucidate possible mechanisms of adverse interaction between IGU and WF, we analyzed the effects of IGU on the pharmacodynamics and pharmacokinetics of WF in rats. IGU was orally administered to male Wistar rats once daily for 5 d at 10 or 30 mg/kg in combination with WF at an oral dose of 0.25 mg/kg. Coadministration of IGU 30 mg/kg enhanced the...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Yamamoto T, Hasegawa K, Onoda M, Tanaka K Tags: Yakugaku Zasshi Source Type: research

An Approach for Safe Medication Assistance in Nursing Homes: A Workshop to Identify Problems of and Plan Measures for Care Workers.
Abstract We conducted a workshop that aimed to clarify problems with care workers supporting medication use in nursing homes, to propose measures for solving these problems, and to raise awareness of these problems among care workers. Eighteen care workers from different fee-based elderly nursing homes were enrolled in the workshop, and divided into four groups. The participants in these groups identified the issues based on their experiences regarding medication-related incidents, and discussed related problems and viable measures using the KJ method. The issues identified by each group were "dropping a medication...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Park H, Miki A, Satoh H, Maki H, Asai K, Konishi Y, Sawada Y Tags: Yakugaku Zasshi Source Type: research

Pharmaceutical Approach for the Diagnosis and Treatment of Malignant Syndrome: A Case Study.
Abstract Since 2012, Matsudo City Hospital has increased the number of pharmacists stationed in the ward on weekday mornings at the emergency care center, the intensive care unit (ICU) and the high care unit (HCU). Multidisciplinary joint meetings and joint conferences are conducted in the emergency care center, and patient and drug information is shared. A 20-year-old man was transferred to our hospital after a traffic accident. He was diagnosed with subarachnoid hemorrhage and brain contusion. He exhibited violent movement and intense restlessness. He was sedated with a continuous intravenous infusion of 5 mg/h m...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Kameda K, Watarai K, Takahashi K, Shoko T, Koinuma M, Ikushima G Tags: Yakugaku Zasshi Source Type: research

Effects of manufacturing conditions on pharmaceutical properties of petrolatum ointment.
In this study, it was clear that the pharmaceutical properties of WP ointment samples were particularly influenced by the paddle-mixer stopping temperature. PMID: 27193304 [PubMed - as supplied by publisher] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 19, 2016 Category: Drugs & Pharmacology Authors: Ashizuka Y, Horisawa E Tags: Yakugaku Zasshi Source Type: research

Inspired Visions of Young Pharmacologists; from Bench to Bedside.
PMID: 27150919 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Sato H, Kurauchi Y Tags: Yakugaku Zasshi Source Type: research

Possible Involvement of Insulin Resistance in the Progression of Cancer Cachexia in Mice.
Abstract Malnutrition is a common problem among cancer patients, affecting up to 85% of patients with certain cancers. In severe cases, malnutrition can progress to cachexia, a specific form of malnutrition characterized by loss of lean body mass and muscle wasting. Although this muscle wasting might be a product of enhanced protein degradation, the precise mechanisms of cancer cachexia are not fully elucidated. Based on basic and clinical research, glucose intolerance and insulin resistance have been postulated to be associated with cancer cachexia. Since insulin in the skeletal muscle inhibits protein degradation...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Ohsawa M, Murakami T, Kume K Tags: Yakugaku Zasshi Source Type: research

Functional Relationship between Arterial Tissue and Perivascular Adipose Tissue in Metabolic Syndrome.
Abstract Metabolic syndrome is a complex of disorders that includes visceral obesity, insulin resistance, hypertension, and dyslipidemia. It is characterized by an increased risk for serious cardiovascular events. Adipocytes are now recognized to contribute to the development of cardiovascular complications in metabolic syndrome via the release of several bioactive substances (adipocytokines). Obesity induces an increase in the volume of perivascular adipose tissue (PVAT), which is located outside the blood vessels. In recent years, PVAT has been reported to produce/release vasoactive adipocytokines. Thus, PVAT can...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Kagota S, Iwata S, Maruyama K, Wakuda H, Shinozuka K Tags: Yakugaku Zasshi Source Type: research

Molecular Understanding of the Acquisition of Resistance to Anti-cancer Drugs Associated with the Exacerbation of Cancer.
Abstract Gefitinib and erlotinib target the ATP cleft in the tyrosine kinase EGFR, which is overexpressed in 40-80 percent of non-small-cell lung cancer (NSCLC) and many other epithelial cancers. However, the application of gefitinib is ultimately limited by the emergence of mutations and other molecular mechanisms conferring drug resistance. Furthermore, it has been considered that acquired resistance to gefitinib is associated with a clinically significant risk of accelerated disease progression. We previously established a new gefitinib-resistant NSCLC cell line, HCC827GR, which harbors the T790M mutation. Using...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Kuzumaki N, Narita M, Ikegami D, Narita M Tags: Yakugaku Zasshi Source Type: research

Gene-manipulated Adipocytes for the Treatment of Various Intractable Diseases.
Abstract Although protein replacement is an effective treatment for serum protein deficiencies such as diabetes and hemophilia, recombinant protein products are not available for all rare inherited diseases due to the instability of the recombinant proteins and/or to cost. Gene therapy is the most attractive option for treating patients with such rare diseases. To develop an effective ex vivo gene therapy-based protein replacement treatment requires recipient cells that differ from those used in standard gene therapy, which is performed to correct the function of the recipient cells. Adipose tissue is an expected s...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Kuroda M, Bujo H, Aso M, Saito Y, Yokote K Tags: Yakugaku Zasshi Source Type: research

Preliminary Evidence for Impaired Brain Activity of Neural Reward Processing in Children and Adolescents with Reactive Attachment Disorder.
Abstract Childhood maltreatment, which markedly increases risks for psychopathology, is associated with structural and functional brain differences. Especially, exposure to parental verbal abuse (PVA) or interparental violence during childhood is associated with negative outcomes such as depression, posttraumatic stress disorder (PTSD), and reduced cognitive abilities. Other forms of childhood maltreatment have been associated with brain structure or developmental alteration. Our earlier studies elucidated potential discernible effects of PVA and witnessing domestic violence during childhood on brain morphology, in...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Tomoda A Tags: Yakugaku Zasshi Source Type: research

Mission and Vision for the Future in University Pharmacy.
PMID: 27150925 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Teramachi H, Matsushita R Tags: Yakugaku Zasshi Source Type: research

Activity and the Role of Keio University Pharmacy.
Abstract Keio University Faculty of Pharmacy opened an insurance pharmacy on its campus in 2001. This pharmacy was opened with the objectives of 1) educating pharmacists to serve the regional community; 2) heightening students' motivation; and 3) providing practical education geared to the needs of actual healthcare settings. Since my appointment as director in 2003, I have led various initiatives to determine an ideal business model for a university pharmacy. This paper reports these initiatives and discusses the mission and future prospects of university pharmacies. In terms of education, all 4th-year students pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2016 Category: Drugs & Pharmacology Authors: Fukushima N Tags: Yakugaku Zasshi Source Type: research