Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins
The intracellular pH (pHi) of most cancers is constitutively higher than that of normal cells and enhances proliferation and cell survival. We found that increased pHi enabled the tumorigenic behaviors caused by somatic arginine-to-histidine mutations, which are frequent in cancer and confer pH sensing not seen with wild-type proteins. Experimentally raising the pHi increased the activity of R776H mutant epidermal growth factor receptor (EGFR-R776H), thereby increasing proliferation and causing transformation in fibroblasts. An Arg-to-Gly mutation did not confer these effects. Molecular dynamics simulations of EGFR suggest...
Source: Signal Transduction Knowledge Environment - September 5, 2017 Category: Science Authors: White, K. A., Ruiz, D. G., Szpiech, Z. A., Strauli, N. B., Hernandez, R. D., Jacobson, M. P., Barber, D. L. Tags: STKE Research Articles Source Type: news

Beware The Plastic Surgeon You Found on Instagram
You may end up with a barber or a dentist instead
Source: WebMD Health - August 30, 2017 Category: Consumer Health News Source Type: news

Looking for A Plastic Surgeon on Instagram? Beware
You may end up with a barber or a dentist instead Source: HealthDay Related MedlinePlus Pages: Internet Safety, Plastic and Cosmetic Surgery
Source: MedlinePlus Health News - August 30, 2017 Category: Consumer Health News Source Type: news

Looking for a Plastic Surgeon on Instagram? Beware
WEDNESDAY, Aug. 30, 2017 -- If you ' re searching Instagram using hashtags for a good #plasticsurgeon, you may end up with a #plasticsurgerydisaster performed by a hair stylist, a barber or an ER doc offering cosmetic surgery on the side. More than...
Source: Drugs.com - Daily MedNews - August 30, 2017 Category: General Medicine Source Type: news

Epidemiology of injuries in men's lacrosse: implications for level, type of play, and position - Barber Foss K, Le Cara E, McCambridge T, Hinton R, Kushner A, Myer G.
OBJECTIVE: The growth in participation in men's lacrosse has increased the likelihood of sport-specific injuries. Despite the exponential growth in men's lacrosse participation, there continues to be a need for specific epidemiological data concerning lacr...
Source: SafetyLit - July 22, 2017 Category: International Medicine & Public Health Tags: Recreational and Sports Issues Source Type: news

Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury - Stephens JA, Salorio CF, Barber AD, Risen SR, Mostofsky SH, Suskauer SJ.
This study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). RESULTS: Compared ...
Source: SafetyLit - July 16, 2017 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

' Full House ' Star Andrea Barber ' s Take On Depression Is Flawless
"A thief of happiness. A thief of hope. A thief of a life well lived."
Source: Healthy Living - The Huffington Post - July 13, 2017 Category: Consumer Health News Source Type: news

Associations between brain drawings following mild traumatic brain injury and negative illness perceptions and post-concussion symptoms at 4  years - Jones KM, Theadom A, Barker-Collo S, Broadbent E, Feigin VL, Feigin V, Barker-Collo S, McPherson K, Theadom A, Jones KM, Jones A, Ao BT, Kydd R, Barber PA, Parag V, Ameratunga S, Starkey N, Dowell A, Kahan M, Christey G, Hardaker N, Brown P.
This study examined associations between brain drawings at 1  month and illness perceptions and post-concussion symptoms at 4...
Source: SafetyLit - June 24, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Trends in antidepressant prescribing to children and adolescents in Canadian primary care: a time-series analysis - Morkem R, Williamson T, Patten S, Queenan JA, Wong ST, Manca D, Barber D.
PURPOSE: The purpose of this study was to describe the trends and patterns of antidepressant (AD) prescribing to children and adolescents in Canadian primary care before and after the black-box warning in 2004. METHODS: Prescription data from the C...
Source: SafetyLit - June 15, 2017 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Kentucky Federal Judge Says Disability Insurer's Offset Was Permitted Under Policy
LOUISVILLE, Ky. - A Kentucky federal judge on May 16 granted a disability insurer's motion to dismiss after determining that the insurer did not act arbitrarily and capriciously by offsetting the claimant's benefits amount with income the claimant earned as a political consultant (Oliver H. Barber III, et al., v. Lincoln National Life Insurance Co., No. 17-34, W.D. Ky., 2017 U.S. Dist. LEXIS 74005).
Source: LexisNexis® Mealey's™ Disability Insurance Legal News - June 13, 2017 Category: Medical Law Source Type: news

The role of online social identity in the relationship between alcohol-related content on social networking sites and adolescent alcohol use - Pegg KJ, O'Donnell AW, Lala G, Barber BL.
Social networking sites (SNSs) are social platforms that facilitate communication. For adolescents, peers play a crucial role in constructing the self online through displays of group norms on SNSs. The current study investigated the role of online social ...
Source: SafetyLit - June 10, 2017 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Executive Voice: At Duke, he ’ll shape the future of ob/gyn care
Dr. Matthew Barber is in a field that he describes as having “a number of very exciting advances” – obstetrics and gynecology. He has now been tasked with adding to and overseeing some of that advancement as head of the department of obstetrics and gynecology at Duke University Medical Center.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 2, 2017 Category: Pharmaceuticals Authors: Cameron Snipes Source Type: news

Anger self-management training for chronic moderate to severe traumatic brain injury: results of a randomized controlled trial - Hart T, Brockway JA, Maiuro RD, Vaccaro M, Fann JR, Mellick D, Harrison-Felix C, Barber J, Temkin N.
OBJECTIVE: To test efficacy of 8-session, 1:1 treatment, anger self-management training (ASMT), for chronic moderate to severe traumatic brain injury (TBI). SETTING: Three US outpatient treatment facilities. PARTICIPANTS: Ninety people with TBI and elevate...
Source: SafetyLit - May 24, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Neighborhood social environment as risk factors to health behavior among African Americans: the Jackson Heart Study - Wang X, Auchincloss AH, Barber S, Mayne SL, Griswold ME, Sims M, Diez Roux AV.
BACKGROUND: Few studies have focused on the impact of neighborhood social environment on changes in smoking and alcohol use over time among African Americans. METHOD: Jackson Heart Study participants were recruited from the Jackson, MS metropolitan...
Source: SafetyLit - May 9, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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