Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Progressing Basic Immunology for Development of New Therapeutic Medicines
Yakugaku Zasshi. 2024;144(5):473-474. doi: 10.1248/yakushi.23-00154-F.NO ABSTRACTPMID:38692919 | DOI:10.1248/yakushi.23-00154-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Jun-Ichi Kashiwakura Keigo Nishida Source Type: research

Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Keigo Nishida Naoya Nakagawa Source Type: research

Mast Cell-Neutrophil Communication Regulates Allergic Diseases
Yakugaku Zasshi. 2024;144(5):483-488. doi: 10.1248/yakushi.23-00154-2.ABSTRACTAllergic diseases (e.g., food allergies) are a growing problem, with increasing numbers of individuals experiencing them worldwide. Congruently, the adverse reactions (e.g., anaphylaxis) associated with the administration of vaccines against emerging infectious diseases such as coronavirus disease 2019 (COVID-19) have become a familiar problem. Allergic diseases, which have a wide variety of symptoms, are difficult to prevent or cure; treatment is currently limited to therapeutic drugs or allergen immunotherapy. Therefore, elucidating new allergi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Ryo Suzuki Source Type: research

Immune Regulation by TNF Receptor-associated Factor 5
Yakugaku Zasshi. 2024;144(5):489-496. doi: 10.1248/yakushi.23-00154-3.ABSTRACTThe tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are intracellular adaptors that regulate cellular signaling through members of the TNFR and Toll-like receptor superfamily. Mammals have seven TRAF molecules numbered sequentially from TRAF1 to TRAF7. Although TRAF5 was identified as a potential regulator of TNFR superfamily members, the in vivo function of TRAF5 has not yet been fully elucidated. We identified an unconventional role of TRAF5 in interleukin-6 (IL-6) receptor signaling involving CD4+ T cells. Mo...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Takanori So Source Type: research

Understanding New Regulatory Mechanism of TCR Signal Transduction
Yakugaku Zasshi. 2024;144(5):497-501. doi: 10.1248/yakushi.23-00154-4.ABSTRACTSignal-transducing adaptor protein-2 (STAP-2) is a unique scaffold protein that regulates several immunological signaling pathways, including LIF/LIF receptor and LPS/TLR4 signals. STAP-2 is required for Fas/FasL-dependent T cell apoptosis and SDF-1α-induced T cell migration. Conversely, STAP-2 modulates integrin-mediated T cell adhesion, suggesting that STAP-2 is essential for several negative and positive T cell functions. However, whether STAP-2 is involved in T cell-antigen receptor (TCR)-mediated T cell activation is unknown. STAP-2 deficie...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Jun-Ichi Kashiwakura Tadashi Matsuda Source Type: research

Frontiers of Physical Pharmaceutical Research by Young Scientists Making Breakthroughs (Symposium of Division of Physical Sciences)
Yakugaku Zasshi. 2024;144(5):503-504. doi: 10.1248/yakushi.23-00178-F.NO ABSTRACTPMID:38692924 | DOI:10.1248/yakushi.23-00178-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Hiroaki Kato Mikako Ogawa Source Type: research

Development of Transdermal Formulation Based on Nanotechnology and Elucidation of Its Drug Delivery Pathways
Yakugaku Zasshi. 2024;144(5):505-510. doi: 10.1248/yakushi.23-00178-1.ABSTRACTTransdermal drug delivery is a formulation in which the drug is absorbed through the skin for systemic action. Its advantages include avoidance of first-pass effects, sustained drug supply, and ease of administration and discontinuation. Drugs administered transdermally transfer into the blood circulation through the stratum corneum, epidermis, and dermis. The stratum corneum on the skin surface plays a barrier function in skin absorption. Therefore, developing of transdermal drug delivery systems requires innovations that overcome the barrier fu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Hiroko Otake Noriaki Nagai Source Type: research

Atomic Force Microscopy to Measure the Mechanical Property of Nanosized Lipid Vesicles and Its Applications
Yakugaku Zasshi. 2024;144(5):511-519. doi: 10.1248/yakushi.23-00178-2.ABSTRACTNanoparticles, including liposomes and lipid nanoparticles, have garnered global attention due to their potential applications in pharmaceuticals, vaccines, and gene therapies. These particles enable targeted delivery of new drug modalities such as highly active small molecules and nucleic acids. However, for widespread use of nanoparticle-based formulations, it is crucial to comprehensively analyze their characteristics to ensure both efficacy and safety, as well as enable consistent production. In this context, this review focuses on our resear...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Yuki Takechi-Haraya Source Type: research

Analysis of the Divalent Cation Blocking in Ion Channels by Crystal Structure and Molecular Dynamics Simulations
In this study, we elucidated the molecular mechanism of the divalent cation block by reproducing the divalent cation block in NavAb. The X-ray crystal structure of divalent-cation-block mutants show electron density in the ion transmission pathway of the divalent cation blocked mutants, indicating that the mutations increasing the hydrophilicity of the inner vestibule of the pore domain enable a divalent cation to stack into the ion pathway. In molecular dynamics simulations, the stacked calcium ion repels the sodium ions near the channel lumen's entrance at the selective filter's bottom. These results suggest the primary ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Katsumasa Irie Source Type: research

Challenges Facing Middle Molecule Drug Discovery and How to Overcome Them
Yakugaku Zasshi. 2024;144(5):527-528. doi: 10.1248/yakushi.23-00191-F.NO ABSTRACTPMID:38692928 | DOI:10.1248/yakushi.23-00191-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Hiroyuki Miyachi Katsumi Maenaka Source Type: research

Evaluation of Solubility and Membrane Permeability of Middle-Molecule Compounds Using Artificial Membranes and Living Cells
Yakugaku Zasshi. 2024;144(5):529-537. doi: 10.1248/yakushi.23-00191-1.ABSTRACTIn contrast to small molecules, middle molecules present a promising therapeutic modality owing to their elevated specificity, minimal adverse effects, capacity to target protein-protein interactions, and, unlike antibody-based drugs, their suitability for oral administration and intracellular target engagement. Post-oral administration, the paramount considerations encompass solubility and membrane permeability during the initial phase until the drug attains systemic circulation. Furthermore, penetration of the cell membrane is essential to acce...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Kayoko Kanamitsu Mayumi Ishii Eri Watanabe Hiroyuki Miyachi Source Type: research

Development of Integrated Database for Experiments and Simulations
Yakugaku Zasshi. 2024;144(5):539-543. doi: 10.1248/yakushi.23-00191-2.ABSTRACTResearchers collect data and use various methods to organize it. Ensuring the reliability and reproducibility of data is crucial, and collaboration across different research fields is on the rise. However, when there is geographical distance, sharing data becomes a challenging task. Therefore, there is a need for the development of a mechanism for sharing data on the web. We have developed an integrated database to facilitate the sharing and management of research data, particularly focusing on small molecules. The integrated database serves as a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Issaku Yamada Naoki Kimura Takao Nomura Satoko Otsuguro Hiroyuki Miyachi Yasuteru Shigeta Katsumi Maenaka Source Type: research

Development of Membrane Permeability Coefficient by Means of Novel Molecular Dynamics Methods
Yakugaku Zasshi. 2024;144(5):545-551. doi: 10.1248/yakushi.23-00191-3.ABSTRACTThe membrane permeability, and its evaluation, is crucial factor in the process of uptake of compounds from outside to inside the cell and in the inhibition of the activity of disease-causing target proteins. Although molecular dynamics (MD) simulations have been shown to be able to reproduce the conformational changes of compounds occurring during membrane permeation, it is still challenging to extract the membrane permeability at an affordable computational workload solely by conventional MD. Indeed, the time scale accessible by MD is far below...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Ryuhei Harada Yuki Mitsuta Yasuteru Shigeta Source Type: research

Syntheses and Structure-Activity Relationship Studies of Antitumor Bicyclic Hexapeptide RA-VII Analogues
Yakugaku Zasshi. 2024;144(5):553-565. doi: 10.1248/yakushi.23-00208.ABSTRACTA series of antitumor bicyclic hexapeptide RA-VII analogues modified at residue 2, 3, or 6 were prepared by the chemical transformation of the hydroxy, methoxy, or carboxy groups or the aromatic rings of natural peptides RA-II, III, V, VII, and X. Analogues with modified side chains or peptide backbones, which cannot be prepared by the chemical transformation of their natural peptides, and newly isolated peptides from Rubia cordifolia roots were synthesized by using protected cycloisodityrosines prepared by the degradation of bis(thioamide) obtaine...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Yukio Hitotsuyanagi Source Type: research

Evaluation of Pharmacy Students' Understanding of Clinical Trials and Research through Questionnaires Before and After the Hospital Practical Training
Yakugaku Zasshi. 2024;144(5):567-576. doi: 10.1248/yakushi.23-00202.ABSTRACTA questionnaire survey was conducted to evaluate practical training and improve education on clinical trial and research. This survey was based on the results of questionnaire before and after the practical training undertaken by 240 pharmaceutical students (Kanto region; 1 university, Tokai region; 2 university, Kinki region; 9 university) at Mie University Hospital between 2011 and 2022. In the questionnaire before practical training, lectures in university (n=219, 91%) were the main source of information on clinical trials and research. Fifty-tw...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Chihiro Shiraishi Mayumi Kotera Yasuyuki Ota Eiko Takeshige Chisato Minamide Rie Kurimoto Aki Sato Miho Inamori Misaki Kataoka Toru Ogura Satoshi Tamaru Takuya Iwamoto Source Type: research