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This page shows you the most recent publications within this specialty of the MedWorm directory.

Dynamic DNA methylation regulates neuronal intrinsic membrane excitability.
This study has implications for human neurological and psychiatric diseases associated with dysregulated intrinsic excitability. PMID: 27555660 [PubMed - in process] (Source: Science Signaling)
Source: Science Signaling - August 26, 2016 Category: Biomedical Science Authors: Meadows JP, Guzman-Karlsson MC, Phillips S, Brown JA, Strange SK, Sweatt JD, Hablitz JJ Tags: Sci Signal Source Type: research

Metformin May Curb Weight Gain in Youth Taking Antipsychotics for Autism
Although atypical antipsychotic medications can help to reduce irritability and agitation in youth with autism spectrum disorder (ASD), these medications are known to cause weight gain and may increase risk of diabetes. Asmall trial published online yesterday inJAMA Psychiatry suggests that metformin, a drug used for treatment of type 2 diabetes, may decrease weight gain in children with ASD.Evdokia Anagnostou, M.D., a senior clinician scientist at the Bloorview Research Institute in Toronto, and colleagues randomly assigned 61 young people (aged 6 to 17) with ASD to receive metformin or placebo for 16 weeks. (All of ...
Source: Psychiatr News - August 25, 2016 Category: Psychiatry Tags: atypical antipsychotics autism autism spectrum disorder Bloorview Christopher McDougle Evdokia Anagnostou Metformin psychiatry Source Type: research

The malaise in the contemporary psychopathology
The objective of this article is to present an interpretation, oriented by psychoanalysis, about malaise in the field of contemporary psychopathology. Finding biomarkers to explain human behavior and its deviations is a dream long mitigated by psychiatry that now receives new investment from the new strategic plan of the National Institute of Mental Health (NIMH), that on one hand encourages the advancement of science, but on the other poses an organicist reductionism. Without taking the opposite position, that is, of a psychologism of mental disorders or denial of biological factors in psychopathology, this text discusses...
Source: Psicologia USP - August 25, 2016 Category: Psychiatry & Psychology Source Type: research

Potential drug-drug interaction in Mexican patients with schizophrenia.
CONCLUSIONS: Our results revealed a high number of patients with schizophrenia receiving two or more drugs. The potential drug-drug interactions observed in the Mexican population are consistent with the concomitant use of antipsychotics, benzodiazepines, and antidepressants prescribed in schizophrenia that could cause central nervous system (CNS) depression and anticholinergic effect. Drug-drug interaction must be considered when the patient with schizophrenia is medicated. PMID: 27552677 [PubMed - as supplied by publisher] (Source: International Journal of Psychiatry in Clinical Practice)
Source: International Journal of Psychiatry in Clinical Practice - August 25, 2016 Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research

Involuntary admissions in Italy: the impact of seasonality.
CONCLUSIONS: Seasonality has an important role in the psychopathology of psychiatric disorders, particularly in bipolar and related disorder, and may represent an influencing factor in hospital admissions and hospitalizations. Seasonal pattern must be considered while managing diagnosis and treatment of mental disorders, with regard to prevention and psychoeducation of patients. PMID: 27551753 [PubMed - as supplied by publisher] (Source: International Journal of Psychiatry in Clinical Practice)
Source: International Journal of Psychiatry in Clinical Practice - August 25, 2016 Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research

Ulnar Neuropathy at the Elbow in Chronic Alcohol-Dependent Subjects
Conclusions: UNE is frequent among alcohol dependent subjects and they must be instructed to avoid abnormal postures and to protect their elbow while working with the elbows flexed and resting on a hard object. (Source: Journal of Clinical Neuromuscular Disease)
Source: Journal of Clinical Neuromuscular Disease - August 25, 2016 Category: Neurology Tags: Original Article Source Type: research

How does gatekeeper training improve suicide prevention for elderly people in nursing homes? A controlled study in 24 centres.
CONCLUSIONS: Having trained gatekeepers has an impact not only for the trained individuals but also for the whole institution where they work, both in terms of managing suicidal residents and routine suicide prevention measures. PMID: 27552322 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - August 25, 2016 Category: Psychiatry Tags: Eur Psychiatry Source Type: research

Altered apolipoprotein C expression in association with cognition impairments and hippocampus volume in schizophrenia and bipolar disorder.
Authors: Knöchel C, Kniep J, Cooper JD, Stäblein M, Wenzler S, Sarlon J, Prvulovic D, Linden DE, Bahn S, Stocki P, Ozcan S, Alves G, Carvalho AF, Reif A, Oertel-Knöchel V Abstract Proteomic analyses facilitate the interpretation of molecular biomarker probes which are very helpful in diagnosing schizophrenia (SZ). In the current study, we attempt to test whether potential differences in plasma protein expressions in SZ and bipolar disorder (BD) are associated with cognitive deficits and their underlying brain structures. Forty-two plasma proteins of 29 SZ patients, 25 BD patients and 93 non-clinical controls wer...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 25, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men.
Authors: Sarubin N, Hilbert S, Naumann F, Zill P, Wimmer AM, Nothdurfter C, Rupprecht R, Baghai TC, Bühner M, Schüle C Abstract Genetic variations in the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) have been associated with maladaptive stress responses and major depressive disorder (MDD). In a case-control study design, we examined whether single nucleotide polymorphisms (SNPs) and haploid genotype (haplotype) associations of MR gene NR3C2, GR gene NR3C1 and genes of GR chaperone molecules FK506 binding protein 5 (FKBP5) and corticotrophin-releasing hormone receptor 1 (CRHR1) differed bet...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 25, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Requirements of Resident Scholarly Activity.
Authors: Balon R, Stromberg N PMID: 27549403 [PubMed - as supplied by publisher] (Source: The Journal of American Association of Directors of Psychiatric Residency Training)
Source: The Journal of American Association of Directors of Psychiatric Residency Training - August 25, 2016 Category: Psychiatry Tags: Acad Psychiatry Source Type: research

Chronic Medical Conditions and Negative Affect; Racial Variation in Reciprocal Associations Over Time
Shervin Assari, Maryam Moghani Lankarani (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - August 25, 2016 Category: Psychiatry Source Type: research

The delaying effect of stigma on mental health help ‐seeking in Sri Lanka
ConclusionReducing stigma may reduce help‐seeking delays during the course of treatment. (Source: Asia-Pacific Psychiatry)
Source: Asia-Pacific Psychiatry - August 25, 2016 Category: Psychiatry Authors: Sunera M. Fernando, Frank P. Deane, Hamish J. McLeod Tags: BRIEF REPORT Source Type: research

Guide for Authors
(Source: Biological Psychiatry)
Source: Biological Psychiatry - August 25, 2016 Category: Psychiatry Source Type: research

Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - August 25, 2016 Category: Psychiatry Source Type: research

Subscribers Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - August 25, 2016 Category: Psychiatry Source Type: research

Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - August 25, 2016 Category: Psychiatry Source Type: research

A brief summary of the articles appearing in this issue of Biological Psychiatry.
Singh et al. (pages 424 –431) conducted a multicenter, double-blind, randomized, placebo-controlled trial to investigate intravenous esketamine for adults with treatment-resistant depression. Compared with placebo, the majority of patients (67%) who were treated with 0.20 or 0.40 mg/kg esketamine showed rapid and signifi cant improvement in depressive symptoms. Adverse events, the most common of which were headache, nausea, and dissociation, were dose dependent. Symptom improvement did not differ between the doses, suggesting that the lower esketamine dose may be more tolerable for patients while maintaining efficac y. (...
Source: Biological Psychiatry - August 25, 2016 Category: Psychiatry Tags: In This Issue Source Type: research

Fibroblast Growth Factor 2 Sits at the Interface of Stress and Anxiety
The role of growth factors in the control of mood and emotions has gained considerable interest. In particular, discoveries during the past decade have pointed to the involvement of the fibroblast growth factor (FGF) family in affect regulation and have underscored the ability of one member, FGF2, to decrease depression and anxiety behaviors in animal models (1). In the present report, Salmaso et al. (2) show that Fgf2 knockout (KO) mice exhibit increased anxiety behavior, and this phenotype is rescued by FGF2 administration in adulthood (2). (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 25, 2016 Category: Psychiatry Authors: Cortney A. Turner, Stanley J. Watson, Huda Akil Tags: Commentary Source Type: research

Is Functional Magnetic Resonance Imaging-Inspired Electroencephalogram Feedback the Next New Treatment in Psychiatry?
Ever since Hans Berger recorded the first electroencephalogram (EEG) in 1924, scientists have struggled to understand which exact regions of the brain are causing the signal on the scalp. This inverse problem has proved quite difficult to crack, despite decades of research. Some researchers have used electrodes within the brain (electrocorticograms) simultaneously with surface electrodes to try to understand the source. Others have recorded functional magnetic resonance imaging (fMRI) blood oxygen level –dependent (BOLD) signals with concurrent surface EEG. (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 25, 2016 Category: Psychiatry Authors: Mark S. George Tags: Commentary Source Type: research

Ketamine for Depression: An Update
A decade has now passed since research into the antidepressant effects of ketamine began in earnest, after the clinical trial reported by Zarate et al. in 2006 (1). In that proof-of-concept study, 18 medication-free patients with treatment-resistant major depressive disorder (TRD) showed a large reduction in core depressive symptoms within hours of receiving a single low-dose 0.5 mg/kg intravenous infusion of ketamine as measured by the 21-item Hamilton Depression Rating Scale compared with saline placebo. (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 25, 2016 Category: Psychiatry Authors: James W. Murrough Tags: Commentary Source Type: research

Citalopram dose reductions in response to safety warning increased hospitalization
A group of Department of Veterans Affairs (VA) patients who had their citalopram doses reduced after a federal safety communication about doses exceeding 40 mg/day experienced a significant increase in hospitalizations and deaths compared with patients whose doses were not reduced, a study has found. The study's authors suggested that the Food and Drug Administration's (FDA's) 2011 safety communication appears to have generated unintended clinical consequences. Study results were published online May 10 in the American Journal of Psychiatry. (Source: The Brown University Psychopharmacology Update)
Source: The Brown University Psychopharmacology Update - August 25, 2016 Category: Psychiatry Tags: Adverse Events Source Type: research

Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder
This study aimed to investigate whether there are differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neurotrophin-3 (NTF3) levels between children with ADHD and healthy controls. A total of 110 treatment-naive children with the combined presentation of ADHD and 44 healthy controls aged 8 –18 years were enrolled in this study. The severity of ADHD symptoms was determined by scores on the Conners’ Parent Rating Scale-Revised Short and Conners’ Teacher Rating Scale-Revised Short. The severity of depression and anxiety symptoms of the c...
Source: European Child and Adolescent Psychiatry - August 25, 2016 Category: Psychiatry Source Type: research

Face transplant: long-term follow-up and results of a prospective open study
This study was registered with ClinicalTrials.gov, number NCT00527280. Findings Two of seven patients died: one at 65 days due to transplant destruction with concomitant pseudomonas infection and the second at 3·4 years after transplantation by suicide. The six patients alive at long-term follow-up presented with functional transplants. Safety endpoints were related to infection in the first month, acute rejection from 1 day to 7 years after transplantation, or side-effects of immunosuppressive therapy. Recurrent rejection episodes justified maintenance therapy with high-dose steroids at high levels in all patients at las...
Source: The Lancet - August 25, 2016 Category: Journals (General) Source Type: research

Associations of Adverse Clinical Course and Ingested Substances among Patients with Deliberate Drug Poisoning: A Cohort Study from an Intensive Care Unit in Japan
ConclusionThese results suggest that judicious prescribing of barbiturates by psychiatrists could reduce the risk of an adverse clinical course when a patient attempts an overdose. (Source: PLoS One)
Source: PLoS One - August 25, 2016 Category: Biomedical Science Authors: Kanako Ichikura Source Type: research

A spectroscopic approach toward depression diagnosis: local metabolism meets functional connectivity
AbstractAbnormal anterior insula (AI) response and functional connectivity (FC) is associated with depression. In addition to clinical features, such as severity, AI FC and its metabolism further predicted therapeutic response. Abnormal FC between anterior cingulate and AI covaried with reduced glutamate level within cingulate cortex. Recently, deficient glial glutamate conversion was found in AI in major depression disorder (MDD). We therefore postulate a local glutamatergic mechanism in insula cortex of depressive patients, which is correlated with symptoms severity and itself influences AI ’s network connectivity in M...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 25, 2016 Category: Neuroscience Source Type: research

Infant Mental Health Training for Child and Adolescent Psychiatry: A Comprehensive Model
(Source: Academic Psychiatry)
Source: Academic Psychiatry - August 25, 2016 Category: Psychiatry Source Type: research

Aggressive Event Incidence using the Staff Observation of Aggression Scale-Revised (SOAS-R): A Longitudinal Study
AbstractThe aim of this study was to identify aggressive event incidence rates in the inpatient psychiatric setting, describe characteristics of events and differences based on aggression target and type (verbal vs. physical). A longitudinal study was carried out of aggressive events identified by workers in four inpatient psychiatric units using the Staff Observation of Aggression Scale-Revised (SOAS-R) over 6  weeks. A total of 113 aggressive events were recorded resulting in a rate of 13.27 events per bed per year. Verbal aggression was demonstrated in 86 % and physical aggression in 57 % of events. Most events (70.8...
Source: Psychiatric Quarterly - August 25, 2016 Category: Psychiatry Source Type: research

Effect of as ‐needed use of intranasal PH94B on social and performance anxiety in individuals with social anxiety disorder
ConclusionsWhile further study is needed, these results, combined with earlier findings, suggest that PH94B could represent a useful as‐needed treatment for SAD, and continue to validate the nasal chemosensory system as a novel mechanism for medication delivery. (Source: Depression and Anxiety)
Source: Depression and Anxiety - August 25, 2016 Category: Psychiatry Authors: Michael R. Liebowitz, Rita Hanover, Ann Draine, Rita Lemming, Jason Careri, Louis Monti Tags: Research Article Source Type: research

The communicative impairment as a core feature of schizophrenia: Frequency of pragmatic deficit, cognitive substrates, and relation with quality of life
Impairments in specific aspects of pragmatic competence, supporting the use of language in context, are largely documented in schizophrenia and might represent an indicator of poor outcome. Yet pragmatics is rarely included in clinical settings. This paper aims to promote a clinical consideration of pragmatics as a target of assessment and intervention. We investigated the frequency of the pragmatic deficit, its cognitive substrates, and the relation with quality of life. (Source: Comprehensive Psychiatry)
Source: Comprehensive Psychiatry - August 25, 2016 Category: Psychiatry Authors: Valentina Bambini, Giorgio Arcara, Margherita Bechi, Mariachiara Buonocore, Roberto Cavallaro, Marta Bosia Source Type: research