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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Cardiac implantable electronic devices in tracheotomized muscular dystrophy patients: Safety and risks
Muscular dystrophies are genetic muscle disorders, in which heart involvement and chronic respiratory impairment affect survival. Cardiac conduction disturbances require implantable cardiac pacemaker. Implantable defibrillators may also be necessary to prevent cardiac sudden death. The safety and risk of cardiac electronic devices' implantation are not known in patients with muscular dystrophy. We aimed to assess the risks related to cardiac implantable electronic devices (CIED) in muscular dystrophy patients ventilated by tracheostomy. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 6, 2016 Category: Cardiology Authors: Abdallah Fayssoil, Arnaud Lazarus, Karim Wahbi, Adam Ogna, Olivier Nardi, Frederic Lofaso, Bernard Clair, David Orlikowski, Djillali Annane Source Type: research

The new generation synthetic reconstituted surfactant CHF5633 suppresses LPS-induced cytokine responses in human neonatal monocytes.
CONCLUSION: Our data confirm that CHF5633 does not exert unintended pro-apoptotic and pro-inflammatory effects in human neonatal monocytes. CHF5633 rather suppressed LPS-induced TNF-α and IL-1β cytokine responses. Our data add to previous work and may indicate anti-inflammatory features of CHF5633 on LPS-induced monocyte cytokine responses. PMID: 27505451 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - August 6, 2016 Category: Molecular Biology Authors: Glaser K, Fehrholz M, Papsdorf M, Curstedt T, Kunzmann S, Speer CP Tags: Cytokine Source Type: research

An Association Between Pain and American Association of Respiratory Care 2010 Guidelines During Tracheal Suctioning
Conclusions: Despite the low number of patients, this study showed that the implementation of the American Association of Respiratory Care 2010 endotracheal suctioning guidelines into practice helps to reduce procedural-induced pain. Therefore, training and continuing education are important for clinical staff performing tracheal suctioning. (Source: Dimensions of Critical Care Nursing)
Source: Dimensions of Critical Care Nursing - August 5, 2016 Category: Nursing Tags: Educational DIMENSION Source Type: research

A Pilot Study Implementing a Protocol Using Dexmedetomidine as a Safe Alternative to Traditional Sedation to Decrease Ventilator Days for Patients Difficult to Extubate
Conclusion: Dexmedetomidine was a safe alternative to traditional sedation for difficult-to-extubate patients when a bolus dose was not given. (Source: Dimensions of Critical Care Nursing)
Source: Dimensions of Critical Care Nursing - August 5, 2016 Category: Nursing Tags: Research DIMENSION Source Type: research

About the effect of pulmonary rehabilitation on lung function in patients with chronic obstructive pulmonary disease.
Abstract Detecting an improvement of lung function in a patient with chronic obstructive pulmonary disease (COPD) following pulmonary rehabilitation (PR) may appear unexpected, but actually recent studies showed that is not so rare. In fact, in a prospective study comparing a group of 190 COPD patients undergoing PR to a group of 67 patients treated only with drugs a mean improvement of FEV1 from 1240 mL to 1252.4 mL was found in the former, while the values changed from 1367 mL to 1150 mL in the latter (p < 0.001). Such improvement was detected also in a study in patients with very severe COPD, as assess...
Source: Respiratory Care - August 5, 2016 Category: Respiratory Medicine Authors: Incorvaia C, Riario-Sforza GG, Ridolo E Tags: Respir Med Case Rep Source Type: research

Fractured metallic tracheostomy tube: A rare complication of tracheostomy.
Abstract Although tracheostomy is a well-accepted procedure for airway management, some early and late complications may occur. Fracture of the tracheostomy tube (TT) is a rare complication, particularly in a patient with long-term use. Herein we report a case of fractured metallic TT migrating into the tracheobronchial tree. Rigid bronchoscopy was performed through the tracheostomy stoma and the fractured tube was successfully removed by a balloon catheter. Appropriate cleaning, routine careful examination, and scheduled replacement of the TT may help prevent this complication. PMID: 27489759 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - August 5, 2016 Category: Respiratory Medicine Authors: So-Ngern A, Boonsarngsuk V Tags: Respir Med Case Rep Source Type: research

Health and survival of HIV perinatally exposed but uninfected children born to HIV-infected mothers
Purpose of review: The number of HIV-exposed but uninfected (HEU) infants exposed to both HIV and multiple antiretroviral drugs in utero and during prolonged breastfeeding is increasing in low-income countries where HIV prevalence is the highest. We review recent evidence on the effects of perinatal/postnatal exposure to maternal HIV and combined antiretroviral therapy (cART) on health outcomes of HEU children (mitochondrial and metabolic toxicity, adverse pregnancy outcomes, neurodevelopment, growth, infectious morbidity, and mortality). Recent findings: Several studies have reported ART-associated mitochondrial toxicity...
Source: Current Opinion in HIV and AIDS - August 5, 2016 Category: Infectious Diseases Tags: SURVIVAL IN THE MODERN ART ERA: Edited by Margaret May and Dominique Costagliola Source Type: research

Post Hoc Analyses of Anxiety Measures in Adult Patients With Generalized Anxiety Disorder Treated With Vilazodone.
CONCLUSIONS: Treatment with vilazodone versus placebo was effective in adult GAD patients, with significant differences between treatment groups found on both psychic and somatic HARS items. TRIAL REGISTRATION: identifiers: NCT01629966, NCT01766401, NCT01844115. PMID: 27486544 [PubMed - in process] (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - August 5, 2016 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

Hypertensive disorders of pregnancy
ConclusionsHypertensive disorders of pregnancy are on the rise worldwide, and this trend is expected to continue. The major contributors to maternal mortality are failure to recognize HDP promptly or to treat the condition adequately. It is essential that anesthesiologists understand the disease process and acquire knowledge of the guidelines governing current obstetrical care in order to provide evidence-based multidisciplinary quality care to these patients. Anesthetic management helps prevent potentially deleterious maternal and fetal outcomes. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - August 5, 2016 Category: Anesthesiology Source Type: research

Takotsubo cardiomyopathy and its relevance to anesthesiology: a narrative review
ConclusionPerioperative TTCM is more common than appreciated and should be considered in any hospitalized patient presenting with acute coronary syndrome and/or hemodynamic instability, acute respiratory distress, as well as cardiac arrhythmias and arrest. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - August 5, 2016 Category: Anesthesiology Source Type: research

EP 47. Direct assessment of psychosocial measures using Eye Tracking Technology in advanced ALS – Can preserved autonomy and psychological wellbeing modify disease course?
Amyotrophic lateral sclerosis is a terminal motor neuron disease, with progressive paralysis, dysarthria, dysphagia and respiratory disabilities. Eye Tracking based computer systems (ETCS) facilitate communication and participation in advanced quadriplegic and anarthric disease state. The impact of ALS on patients and caregivers wellbeing is controversial, with patients showing surprisingly preserved psychological functioning in some studies. Quality of Life, depression and the impact of communicative functioning, especially ETCS usage in the advanced, quadriplegic disease state has not yet been investigated in a direct, f...
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: K. Linse, W. R üger, M. Joos, H. Schmitz-Peiffer, A. Storch, A. Hermann Source Type: research

EP 42. Smooth muscle involvement in Glycogenosis Type II: Thalamus hemorrhage, increased blood flow and dolichoectasia in a late-onset Pompe patient
Pompe disease (Glycogenosis Type II) is a rare autosomal-recessive disorder caused by mutations in the GAA gene encoding for the lysosomal α-glucosidase (acid maltase, GAA). The reduced enzyme activity results in glycogen accumulation in several tissues, particularly skeletal and cardiac muscles, leading to muscular weakness, respiratory and cardiac insufficiency. Enzyme replacement therapy (ERT) has been shown to delay ventilator dep endence and a prolong survival. However, in Pompe disease also smooth muscles are affected, but only little is known about the influence of glycogen accumulation in cerebral arteries and its...
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: O. Hensel, I. Schneider, S. Zierz Source Type: research

EP 9. GPi Deep Brain Stimulation for the treatment of status distonicus in tardive dystonia
Dystonia is a movement disorder due to sustained muscle contractions that cause twisting and repetitive movements conditioning abnormal postures. Tardive dystonia generally follows long treatment with neuroleptics. An extreme condition called status distonicus may even be life threatening, determining spasm of axial musculature leading to respiratory or cardiac arrest. Bilateral pallidotomy provided significant benefit to dystonic symptoms in some patients; moreover, in recent years, pallidotomy has been replaced from pallidal DBS; pallidal DBS is particularly effective both in primitive generalized dystonia and in tardive...
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: A. Trezza, A. Landi, D. Pirillo, A. Antonini, E.P. Sganzerla Source Type: research

Clindamycin confers no extra benefit for kids with SSSS
MINNEAPOLIS – A large single-site case review found that most pediatric patients with staphylococcal scalded skin syndrome (SSSS) had a classic presentation, often preceded by an upper respiratory... (Source: Hospitalist News)
Source: Hospitalist News - August 5, 2016 Category: Hospital Management Source Type: research

Chronic breathlessness: silent and deadly
No abstract available (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - August 5, 2016 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by David C. Currow and Miriam J. Johnson Source Type: research

What can we learn about breathlessness from population-based and administrative health data?
Purpose of review: To review the findings and methodological strengths and limitations of studies of breathlessness using population-based or routinely collected data, including the novel methodology of the registry-based randomized controlled trial (R-RCT). Recent findings: Breathlessness severe enough to restrict activity is common and increases in the last months of life both among elderly in the community and among patients in specialized palliative care. During the last week of life, risk factors for more severe breathlessness have been identified. Patients with advanced chronic obstructive or interstitial lung disea...
Source: Current Opinion in Supportive and Palliative Care - August 5, 2016 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by David C. Currow and Miriam J. Johnson Source Type: research

Service delivery of complex interventions for refractory breathlessness
Purpose of review: The review considers the evidence for different service models existing for helping people manage the chronic, irreversible breathlessness that accompanies advanced disease. Recent findings: Many of the service models that are delivering care have not yet published their results in the scientific literature because these ideas, and the methods to evaluate them, are relatively new. There are three randomized controlled trials published which demonstrate the effectiveness of this approach and one which suggests that more episodes of some intervention components are not necessarily better. Summary: Breath...
Source: Current Opinion in Supportive and Palliative Care - August 5, 2016 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by David C. Currow and Miriam J. Johnson Source Type: research

Physiological and functional failure in chronic obstructive pulmonary disease, congestive heart failure and cancer: a debilitating intersection of sarcopenia, cachexia and breathlessness
Purpose of review: Loss of skeletal muscle mass and cachexia are important manifestations of chronic obstructive pulmonary disease and have been associated with breathlessness, functional limitation and poor prognosis. A number of other life-limiting illnesses, including cancer and chronic heart failure as well as acute conditions seen in ICU such as sepsis, are characteristically associated with cachexia and sarcopenia. These conditions may have respiratory muscle atrophy of sufficient magnitude to contribute to the development of breathlessness and associated functional limitation. The purpose of this review is to summar...
Source: Current Opinion in Supportive and Palliative Care - August 5, 2016 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by David C. Currow and Miriam J. Johnson Source Type: research

Breathlessness and inflammation: potential relationships and implications
Purpose of review: Breathlessness and chronic inflammation both span a wide range of disease contexts and hold prognostic significance. The possibility of a causal relationship between the two has been hypothesized. The aims of this article are to review the intersections between breathlessness and inflammation in the literature, describe potential mechanisms connecting the two phenomena, and discuss the potential clinical implications of a causal relationship. Recent findings: There is a very limited literature exploring the relationship between systemic inflammation and breathlessness in chronic obstructive pulmonary di...
Source: Current Opinion in Supportive and Palliative Care - August 5, 2016 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by David C. Currow and Miriam J. Johnson Source Type: research

Thromboembolic disease and breathlessness
This study reviews the challenges of VTE management within supportive and palliative care, the new oral anticoagulants and the management of VTE in cases in which the evidence is lacking. (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - August 5, 2016 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by David C. Currow and Miriam J. Johnson Source Type: research

Inspiring change: humanities and social science insights into the experience and management of breathlessness
This article discusses a number of current issues in understanding the experience of breathlessness. Recent findings: Effective communication concerning the experience of breathlessness is crucial for diagnosis, to identify appropriate treatment, and to provide patients with the capacity to self-manage their condition. However, there is an evident disconnect between the way breathlessness is understood between clinical and lay perspectives, in terms of awareness of breathlessness, the way symptoms are expressed, and acknowledgement of how it affects the daily lives of patients. Summary: The review highlights the need for...
Source: Current Opinion in Supportive and Palliative Care - August 5, 2016 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by David C. Currow and Miriam J. Johnson Source Type: research

Montelukast, current indications and prospective future applications.
Authors: Kittana N, Hattab S, Ziyadeh-Isleem A, Jaradat N, Zaid AN Abstract INTRODUCTION: Montelukast is recommended for the treatment of asthma, exercise -induced bronchospasm and allergic rhinitis. Several trials demonstrated potential therapeutic effects in other respiratory conditions, and different animal-model-based studies explored potential pharmacological actions in non-respiratory conditions. AREAS COVERED: Clinical investigations on the pharmacotherapeutic effects of montelukast, in addition to in-vivo studies on animal models of non-respiratory diseases. The data discussed in this review were mainly...
Source: Expert Review of Respiratory Medicine - August 5, 2016 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Analysis of RTEL1 and PCDHGB6 promoter methylation in circulating free-DNA of lung cancer patients using liquid biopsy: A pilot study.
CONCLUSIONS: The evaluation of RTEL1 and PCDHGB6 promoter methylation may be an useful tool for non-invasive diagnosis of LC in liquid biopsy. PMID: 27485611 [PubMed - as supplied by publisher] (Source: Experimental Lung Research)
Source: Experimental Lung Research - August 5, 2016 Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research

Path to Health Asthma Study: a survey of pediatric asthma in an urban community.
CONCLUSION: Urban minority children living in low-income communities face neighborhood-specific asthma triggers and challenges to care. Studies conducted in urban neighborhoods, with collaboration from community members, will highlight the need of comprehensive services to account for community-centric social determinants. PMID: 27485682 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - August 5, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Individual Factors, Neighborhood Social Context and Asthma at Age 5 Years.
Conclusion Even after adjustment for several individual level factors, neighborhood disorder was associated with caregiver-report of asthma in this nationally-representative sample of 5 year old children. Further research is needed to better understand how risk factors at different levels of the socio-ecological framework may interact to affect childhood asthma development. PMID: 27485524 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - August 5, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Influence of Asthma Status on Sleep Variability in Overweight/Obese Youth.
CONCLUSION: Findings suggest that asthma status confers risk for more week-to-weekend variability among currently OV/OB youth, and that greater variability shortens the weekday sleep period. Further research on reasons for greater week-to-weekend sleep variability in asthma is needed. PMID: 27485318 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - August 5, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Significant phenotype variability of congenital central hypoventilation syndrome in a family with polyalanine expansion mutation of the PHOX2B gene.
CONCLUSION: Repeated respiratory failure of girl was explained by PHOX2B mutation and Ondina curse. Proband´s father has incompletely penetrated PHOX2B heterozygous mutation as well and proband´s grandmother died probably from the consequences of drug interaction with PHOX2B mutated background as well. Both daughter and father currently require overnight mechanical ventilatory support. Although most PHOX2B mutations occur de novo, our case is a rare three generation family affected by autosomal dominant inheritance with incomplete penetrance manifested as the late-form of CCHS and proven PHOX2B mutation in two generation...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - August 5, 2016 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Air pollution, aeroallergens and admissions to pediatric emergency room for respiratory reasons in Turin, northwestern Italy
This study looked at the short-term association of air pollution concentrations with Emerge... (Source: BMC Public Health)
Source: BMC Public Health - August 5, 2016 Category: Consumer Health News Authors: Roberto Bono, Valeria Romanazzi, Valeria Bellisario, Roberta Tassinari, Giulia Trucco, Antonio Urbino, Claudio Cassardo, Consolata Siniscalco, Pierpaolo Marchetti and Alessandro Marcon Source Type: research

A case –control study of innate immunity pathway gene polymorphisms in Puerto Ricans reveals association of toll-like receptor 2 +596 variant with asthma
For many years, African Dust Storms (ADE) has been thought to be associated with high prevalence of asthma in Puerto Rico (PR). Endotoxins (ENX) have been associated with ADE particulate matter (PM) and are kn... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 5, 2016 Category: Respiratory Medicine Authors: Mario G. Ortiz-Mart ínez, Orquídea Frías-Belén, Sylvette Nazario-Jiménez, María López-Quintero, Rosa I. Rodríguez-Cotto and Braulio D. Jiménez-Vélez Source Type: research

Sedation during bronchoscopy: data from a nationwide sedation and monitoring survey
There is limited knowledge on practice patterns in procedural sedation and analgesia (PSA), the use of propofol, and monitoring during flexible bronchoscopy (FB). The purpose of this study was to assess the cu... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 5, 2016 Category: Respiratory Medicine Authors: Thomas Gaisl, Daniel J. Bratton, Ludwig T. Heuss, Malcolm Kohler, Christian Schlatzer, Marco P. Zalunardo, Martin Frey and Daniel Franzen Source Type: research

Spindle cell sarcomatoid carcinoma of the trachea: first case report of surgical resection
Primary malignant tracheal tumors are rare, accounting for approximately 0.2  % of respiratory tract tumors yearly, with squamous cell carcinomas and adenoid cystic carcinomas accounting for two-thirds of these... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - August 5, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Juan P. Gurria, David M. De Acosta, Niloufar Hafezi, Eman B. Yousif, Ehab AlAmeer and Richard C. Anderson Source Type: research

Behavioral interventions to reduce inappropriate antibiotic prescribing: a randomized pilot trial
Clinicians frequently prescribe antibiotics inappropriately for acute respiratory infections (ARIs). Our objective was to test information technology-enabled behavioral interventions to reduce inappropriate an... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - August 5, 2016 Category: Infectious Diseases Authors: Stephen D. Persell, Jason N. Doctor, Mark W. Friedberg, Daniella Meeker, Elisha Friesema, Andrew Cooper, Ajay Haryani, Dyanna L. Gregory, Craig R. Fox, Noah J. Goldstein and Jeffrey A. Linder Source Type: research

ATP7A Is Essential for Redox Balance in Mitochondria [Metabolism]
Copper-transporting ATPase ATP7A is essential for mammalian copper homeostasis. Loss of ATP7A activity is associated with fatal Menkes disease and various other pathologies. In cells, ATP7A inactivation disrupts copper transport from the cytosol into the secretory pathway. Using fibroblasts from Menkes disease patients and mouse 3T3-L1 cells with a CRISPR/Cas9-inactivated ATP7A, we demonstrate that ATP7A dysfunction is also damaging to mitochondrial redox balance. In these cells, copper accumulates in nuclei, cytosol, and mitochondria, causing distinct changes in their redox environment. Quantitative imaging of live cells ...
Source: Journal of Biological Chemistry - August 5, 2016 Category: Chemistry Authors: Bhattacharjee, A., Yang, H., Duffy, M., Robinson, E., Conrad-Antoville, A., Lu, Y.-W., Capps, T., Braiterman, L., Wolfgang, M., Murphy, M. P., Yi, L., Kaler, S. G., Lutsenko, S., Ralle, M. Tags: Molecular Bases of Disease Source Type: research

SILAC ‐based quantitative proteomic analysis of secretome of Marc‐145 cells infected with porcine reproductive and respiratory syndrome virus
This article is protected by copyright. All rights reserved (Source: Proteomics)
Source: Proteomics - August 5, 2016 Category: Biochemistry Authors: Fuwei Zhao, Liurong Fang, Dang Wang, Tao Song, Ting Wang, Yinghao Xin, Huanchun Chen, Shaobo Xiao Tags: Research Article Source Type: research

Structural characterization, in-vivo acute systemic toxicity assessment and in-vitro intestinal absorption properties of tilapia (Oreochromis niloticus) skin acid and pepsin solublilized type − I collagen
Publication date: Available online 4 August 2016 Source:Process Biochemistry Author(s): Jingyi Zhang, Elango Jeevithan, Bin Bao, Chaoyan Zhang, Kaili Gao, Shujun Wang, Wenhui Wu Acid-soluble (ASC) and pepsin-soluble (PSC) collagens were isolated from tilapia skin and were characterized as type I collagen. The T d (denaturation temperature) of ASC and PSC was 26.80and 28.20°C, respectively. CD (circular dichroism) and FTIR (Fourier transform infrared) spectra of ASC and PSC were slightly different, which confirmed that limited digestion by pepsin disrupted the triple helical structure of collagen. The microstructure depic...
Source: Process Biochemistry - August 5, 2016 Category: Biochemistry Source Type: research

Ciprofloxacin provokes SOS-dependent changes in respiration and membrane potential and causes alterations in the redox status of Escherichia coli
Publication date: Available online 4 August 2016 Source:Research in Microbiology Author(s): Galina V. Smirnova, Aleksey V. Tyulenev, Nadezda G. Muzyka, Mikhail A. Peters, Oleg N. Oktyabrsky An in-depth understanding of the physiological response of bacteria to antibiotic-induced stress is needed for development of new approaches to combatting microbial infections. Fluoroquinolone ciprofloxacin causes phase alterations in Escherichia coli respiration and membrane potential that strongly depend on its concentration. Concentrations lower than the optimal bactericidal concentration (OBC) do not inhibit respiration during the ...
Source: Research in Microbiology - August 5, 2016 Category: Microbiology Source Type: research

Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus
The objectives of this study were to investigate associations between numbers of CD163 and CD169 positive macrophages, cathepsin positive areolae, and type 2 PRRSV load at the maternal –fetal interface in order to examine important factors related to transplacental infection. On gestation day 85 ± 1, naïve pregnant gilts were inoculated with PRRSV (n = 114) or were sham inoculated (n = 19). At 21 days post-inoculation (dpi), dams and their litters were humanely euthanized and necropsied. Samples of the maternal–fetal interface (uterus with fully attached placenta) and fetal thymus were collected for analysis b...
Source: Veterinary Research - August 5, 2016 Category: Veterinary Research Source Type: research

Multiple timescale mixed bursting dynamics in a respiratory neuron model
AbstractExperimental results in rodent medullary slices containing the pre-B ötzinger complex (pre-BötC) have identified multiple bursting mechanisms based on persistent sodium current (INaP) and intracellular Ca2+. The classic two-timescale approach to the analysis of pre-B ötC bursting treats the inactivation ofINaP, the calcium concentration, as well as the Ca2+-dependent inactivation of IP3 as slow variables and considers other evolving quantities as fast variables. Based on its time course, however, it appears that a novel mixed bursting (MB) solution, observed both in recordings and in model pre-B ötC neurons, in...
Source: Journal of Computational Neuroscience - August 5, 2016 Category: Neuroscience Source Type: research

Defining preB ötzinger Complex Rhythm- and Pattern-Generating Neural Microcircuits In Vivo
Publication date: 3 August 2016 Source:Neuron, Volume 91, Issue 3 Author(s): Yan Cui, Kaiwen Kam, David Sherman, Wiktor A. Janczewski, Yu Zheng, Jack L. Feldman Normal breathing in rodents requires activity of glutamatergic Dbx1-derived (Dbx1+) preBötzinger Complex (preBötC) neurons expressing somatostatin (SST). We combined in vivo optogenetic and pharmacological perturbations to elucidate the functional roles of these neurons in breathing. In transgenic adult mice expressing channelrhodopsin (ChR2) in Dbx1+ neurons, photoresponsive preBötC neurons had preinspiratory or inspiratory firing patterns associated with e...
Source: Neuron - August 5, 2016 Category: Neuroscience Source Type: research

Mental health status following severe sulfur mustard exposure: a long ‐term study of Iranian war survivors
ConclusionThe psychiatric morbidity in the chemically injured populations was remarkable and significantly different between the populations. The prevalence of mental illness in these groups highlights the need for the appropriate provision of mental health services. (Source: Asia-Pacific Psychiatry)
Source: Asia-Pacific Psychiatry - August 5, 2016 Category: Psychiatry Authors: Shahriar Khateri, Mohammadreza Soroush, Naghmeh Mokhber, Mohammadreza Sedighimoghaddam, Ehsan Modirian, Batool Mousavi, Seyed Javad Mousavi, Maryam Hosseini Tags: ORIGINAL ARTICLE Source Type: research

Current and future developments in the field of central sleep apnoea
Central sleep apnoea (CSA) occurs in ~30–50% of patients with heart failure (HF) with reduced left ventricular ejection fraction (LVEF) and in as much as in 18–30% of patients with preserved LVEF. In HF patients, it is characterized by periodic breathing also known as the Cheyne–Stokes respiration followed by pauses of breathing. Central sleep apnoea remains often unrecognized due to its chronic and insidious incidences. Patients may report excessive daytime somnolence, poor sleep quality, nocturnal angina, recurrent arrhythmias, refractory HF symptoms, or demonstrate abnormal respiratory pattern or apnoe...
Source: Europace - August 5, 2016 Category: Cardiology Authors: Bekfani, T., Abraham, W. T. Tags: REVIEW Source Type: research

Ethnobotanical investigation on medicinal plants in the Vesuvio National Park (Campania, Southern Italy)
Conclusion The number of medicinal plants reported in this paper reflects a well-preserved traditional popular knowledge (TPK) of the elderly people living in the rural areas and in the small villages of VNP. The conservation of TPK is owed to the persistence of an oral tradition that safeguard the use of plants as herbal medicine. We realized that while the use of some wild plants is decreasing, people continue to gather some cultivated and invasive plants for preparing remedies. Researches like this are necessary to protect ancient memories, to promote the transfer of information to the younger generations, to preserve e...
Source: Journal of Ethnopharmacology - August 5, 2016 Category: Drugs & Pharmacology Source Type: research

Immunologic mechanisms of fingolimod and the role of immunosenescence in the risk of cryptococcal infection: A case report and review of literature
Publication date: Available online 4 August 2016 Source:Multiple Sclerosis and Related Disorders Author(s): Elena Grebenciucova, Anthony T. Reder, Jacqueline T. Bernard Background Fingolimod is a disease-modifying agent used in the treatment of relapsing/remitting multiple sclerosis. In MS clinical studies, the overall rate of infections in fingolimod group was overall similar to placebo, except for slightly more common lower respiratory tract infections and to a lesser extent HSV. Recently, an increasing number of cryptococcal infections associated with a long-term use of this medication have been reported. Methods We re...
Source: Multiple Sclerosis and Related Disorders - August 5, 2016 Category: Neurology Source Type: research

Early severe anemia as the first sign of cystic fibrosis
Conclusion: In early infancy severe anemia in the absence of respiratory symptoms can be the first sign of CF. CF should be considered in the differential diagnosis of severe anemia in infants. Anemia can occur several months before respiratory symptoms in patients with CF and may be caused due to several reasons.What is Known:•Severe anemia as a first sign is reported to occur rarely in patients with cystic fibrosis.•Although anemia is well known in cystic fibrosis, factors that cause severe anemia are not known clearly.What is New:•Thisstudy shows the importance of severe anemia as the first sign of cystic fibrosis...
Source: European Journal of Pediatrics - August 5, 2016 Category: Pediatrics Source Type: research

Heart Rate Variability Moderates the Association Between Separation-Related Psychological Distress and Blood Pressure Reactivity Over Time
Divorce is a stressor associated with long-term health risk, though the mechanisms of this effect are poorly understood. Cardiovascular reactivity is one biological pathway implicated as a predictor of poor long-term health after divorce. A sample of recently separated and divorced adults (N = 138) was assessed over an average of 7.5 months to explore whether individual differences in heart rate variability—assessed by respiratory sinus arrhythmia—operate in combination with subjective reports of separation-related distress to predict prospective changes in cardiovascular reactivity, as indexed by blood pressur...
Source: Psychological Science - August 5, 2016 Category: Psychiatry & Psychology Authors: Bourassa, K. J., Hasselmo, K., Sbarra, D. A. Tags: Research Articles Source Type: research

Injection anaesthesia with fentanyl-midazolam-medetomidine in adult female mice: importance of antagonization and perioperative care
Injection anaesthesia is commonly used in laboratory mice; however, a disadvantage is that post-anaesthesia recovery phases are long. Here, we investigated the potential for shortening the recovery phase after injection anaesthesia with fentanyl–midazolam–medetomidine by antagonization with naloxone–flumazenil–atipamezole. In order to monitor side-effects, the depth of anaesthesia, heart rate (HR), core body temperature (BT) and concentration of blood gases, as well as reflex responses, were assessed during a 50 min anaesthesia. Mice were allowed to recover from the anaesthesia in their home cages e...
Source: Laboratory Animals - August 5, 2016 Category: Research Authors: Fleischmann, T., Jirkof, P., Henke, J., Arras, M., Cesarovic, N. Tags: Original Articles Source Type: research

Mild, moderate, and severe intensity cut-points for the Respiratory Distress Observation Scale
Conclusions Intensity cut-point enhances the clinical utility of the RDOS. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - August 5, 2016 Category: Respiratory Medicine Source Type: research