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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

Antibodies and tuberculosis
Tuberculosis (TB) remains a major public health problem internationally, causing 9.6 million new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Gu érin vaccine is the only licensed vaccine against TB, but its protective effect does not extend to controlling the development of infectious pulmonary disease in adults. The development of a more effective vaccine against TB is therefore a pressing need for global health. Although it is established that cell-mediated immunity is necessary for the control of latent infection, the presupposition that such immunity is sufficient for vaccine-induced protectio...
Source: Tuberculosis - August 27, 2016 Category: Respiratory Medicine Authors: Ashley J. Jacobs, Juthathip Mongkolsapaya, Gavin R. Screaton, Helen McShane, Robert J. Wilkinson Tags: Review Source Type: research

High body mass index is associated with heightened systemic and mycobacterial antigen - specific pro-inflammatory cytokines in latent tuberculosis
High body mass index (HBMI) has been shown to be protective against active tuberculosis (TB), although the biological mechanism underlying this protection is poorly understood. The immunological association between HBMI and latent TB has never been examined. In order to study the association of HBMI with latent TB, we examined the circulating and TB- antigen or mitogen stimulated levels of a large panel of cytokines in individuals with latent TB (LTB) and high or normal body mass index (HBMI or NBMI). (Source: Tuberculosis)
Source: Tuberculosis - August 27, 2016 Category: Respiratory Medicine Authors: Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Chandrakumar Dolla, Paul Kumaran, Subash Babu Tags: Immunological Aspects Source Type: research

A rare cause of cavitatory pneumonia
Publication date: Available online 27 August 2016 Source:Respiratory Medicine Case Reports Author(s): N.S. Harsha, H.S. Sandeepa, S. Hemantha Kumar, B. Prakash, K. Jayalakshmi Radiographic findings of thick walled cavities in the lungs are typically seen in mycobacterial infections, malignant lesions, fungal infections, pulmonary vasculitis or other inflammatory lesions of the lungs. Necrotizing infections of the lungs caused by gram negative bacteria (Klebsiella, Psudomonas, Legionella) and Staphylococcus aureus may also form cavities of varying thickness, with consolidation. Escherichia coli pneumonia causing pulmonary ...
Source: Respiratory Medicine Case Reports - August 27, 2016 Category: Respiratory Medicine Source Type: research

Relation of Concavity in the Expiratory Flow-Volume Loop to Dynamic Hyperinflation during Exercise in COPD
Publication date: Available online 26 August 2016 Source:Respiratory Physiology & Neurobiology Author(s): Janos Varga, Richard Casaburi, Shuyi Ma, Ariel Hecht, David Hsia, Attila Somfay, Janos Porszasz Active expiration during exercise can increase intrathoracic pressure yielding concavity in the expiratory flow-volume loop in COPD. We investigated the relationship between this concavity and dynamic hyperinflation (DH). 17 COPD patients (FEV1: 38±10%pred, GOLD stage 3-4) and 12 healthy subjects performed cycle ergometer incremental exercise. Expiratory limb of the spontaneous flow-volume loop was analyzed breath-...
Source: Respiratory Physiology and Neurobiology - August 27, 2016 Category: Respiratory Medicine Source Type: research

Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial
Publication date: Available online 27 August 2016 Source:The Lancet Respiratory Medicine Author(s): Paul M O'Byrne, Hristo Metev, Margareta Puu, Kai Richter, Christina Keen, Mohib Uddin, Bengt Larsson, Marie Cullberg, Parameswaran Nair Background Airway neutrophilic inflammation is a pathological feature in some patients with severe asthma. Stimulation of the chemokine receptor CXCR2 mediates neutrophil migration into the airways. We investigated the safety and efficacy of AZD5069, a CXCR2 antagonist, as an add-on therapy in patients with uncontrolled severe asthma. Methods In this multicentre, randomised, double-blind, p...
Source: The Lancet Respiratory Medicine - August 27, 2016 Category: Respiratory Medicine Source Type: research

Neutrophilic asthma: a distinct target for treatment?
Publication date: Available online 27 August 2016 Source:The Lancet Respiratory Medicine Author(s): Kian Fan Chung (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - August 27, 2016 Category: Respiratory Medicine Source Type: research

Dementia in patients suffering from critical limb ischemia
Critical limb ischemia (CLI) is a disease that is most prevalent in the elderly population. This group of patients includes patients suffering from comorbidities such as dementia. Mortality rates of both CLI and dementia are higher when compared to the non-affected population. These demented vascular patients are often deemed unfit for surgery and at risk of respiratory and cardiovascular adverse events. Unfortunately, current literature is lacking in to determining the optimal treatment for demented patients suffering from CLI. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - August 27, 2016 Category: Surgery Authors: S.L. Steunenberg, A. te Slaa, G.H. Ho, E.J. Veen, H.G.W. de Groot, L. van der Laan Source Type: research

Early extubation reduces respiratory complications and hospital length of stay following repair of abdominal aortic aneurysms
Early extubation after cardiac surgery is associated with decreased hospital stay and resource savings with similar mortality and has led to the widespread use of early extubation protocols. In the Vascular Quality Initiative, there is significant regional variation in the frequency of extubation in the operating room (endovascular aneurysm repair [EVAR], 77%-97%; open repair, 30%-70%) after repair of intact abdominal aortic aneurysms (AAAs). However, the effects of extubation practices on patient outcomes after repair of AAAs are unclear. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - August 27, 2016 Category: Surgery Authors: Sara L. Zettervall, Peter A. Soden, Katie E. Shean, Sarah E. Deery, Klaas H.J. Ultee, Matthew Alef, Jeffrey J. Siracuse, Marc L. Schermerhorn, Vascular Study Group of New England Tags: Clinical paper Source Type: research

Gold nanorods inhibit respiratory syncytial virus by stimulating the innate immune response
In this study, we showed that gold nanorods (GNRs) inhibit RSV in HEp-2 cells and BALB/c mice by 82% and 56%, respectively. The RSV inhibition correlated with marked upregulated antiviral genes due to GNR mediated TLR, NOD-like receptor and RIG-I-like receptor signaling pathways. Transmission electron microscopy of lungs showed GNRs in the endocytotic vesicles and histological analyses indicated infiltration by neutrophils, eosinophils and monocytes correlating with clearance of RSV. In addition, production of cytokines and chemokines in the lungs indicates recruitment of immune cells to counter RSV replication. To our kno...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - August 27, 2016 Category: Nanotechnology Source Type: research

Autosomal recessive agammaglobulinemia associated with an IGLL1 gene missense mutation
A full term, 2-month-old, white girl presented with respiratory distress and hypoxia. Results of chest radiography were consistent with bilateral upper lobe pneumonia; no organism was identified, and a full recovery was achieved after 14 days of antibiotics and supportive therapy. Because of persistent marked leukocytosis (white blood cell count, 51 –54.2 × 103/mm3) and thrombocytosis (platelet count, 455–600 × 103/mm3), bone marrow was examined; no indication of malignant transformation was noted. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 27, 2016 Category: Allergy & Immunology Authors: Kristina T. Gemayel, Gary W. Litman, Panida Sriaroon Tags: Letter Source Type: research

Utilization of a Gum Elastic Bougie to Facilitate Single Lung Intubation
Patients with severe pulmonary hemorrhage due to unilateral trauma or a bleeding cancer often present to the Emergency Department (ED) in acute respiratory distress. While it is generally recommended to perform single lung intubation, most ED providers do not have access to or are not familiar with double lumen endotracheal tubes and blind insertion of an endotracheal tube to maximum depth does not ensure that the proper (non-hemorrhagic) lung is ventilated. Therefore, single lung intubation may be significantly delayed in these patients. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - August 27, 2016 Category: Emergency Medicine Authors: Michael Gottlieb, Vibhu Sharma, John Field, Michael Rozum, John Bailitz Tags: Brief Report Source Type: research

Brain Dysplasia Associated with Ciliary Dysfunction in Infants with Congenital Heart Disease
To test for associations between abnormal respiratory ciliary motion (CM) and brain abnormalities in infants with congenital heart disease (CHD) (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - August 27, 2016 Category: Pediatrics Authors: Ashok Panigrahy, Vincent Lee, Rafael Ceschin, Giulio Zuccoli, Nancy Beluk, Omar Khalifa, Jodie K. Votava-Smith, Mark DeBrunner, Ricardo Munoz, Yuliya Domnina, Victor Morell, Peter Wearden, Joan Sanchez De Toledo, William Devine, Maliha Zahid, Cecilia W. L Tags: Original Articles Source Type: research

Progress in pediatrics in 2015: choices in allergy, endocrinology, gastroenterology, genetics, haematology, infectious diseases, neonatology, nephrology, neurology, nutrition, oncology and pulmonology
AbstractThis review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature. Epidemiological studies have evidenced th...
Source: Italian Journal of Pediatrics - August 27, 2016 Category: Pediatrics Source Type: research

New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase
Publication date: Available online 27 August 2016 Source:Antiviral Research Author(s): Rachel Fearns, Jerome Deval Worldwide, respiratory syncytial virus (RSV) causes severe disease in infants, the elderly, and immunocompromised people. No vaccine or effective antiviral treatment is available. RSV is a member of the non-segmented, negative-strand (NNS) group of RNA viruses and relies on its RNA-dependent RNA polymerase to transcribe and replicate its genome. Because of its essential nature and unique properties, the RSV polymerase has proven to be a good target for antiviral drugs, with one compound, ALS-8176, having alre...
Source: Antiviral Therapy - August 27, 2016 Category: Virology Source Type: research

Errors in Sepsis Management
A 72-year-old woman with coronary artery disease, pulmonary hypertension, and chronic obstructive pulmonary disease who used oxygen at home presented to the emergency department (ED) with left-sided abdominal pain and shortness of breath. Her temperature was 38.6 ° C (101.5° F), with heart rate of 115 beats per minute, blood pressure of 104/68 mm Hg, respiratory rate of 28 breaths per minute, and oxygen saturation of 86% on baseline 2 L. She had been hospitalized for an exacerbation of chronic obstructive pulmonary disease three weeks earlier. (Source: AORN Journal)
Source: AORN Journal - August 26, 2016 Category: Nursing Tags: Column Source Type: research

Functional Capacity, Respiratory Muscle Strength, and Oxygen Consumption Predict Mortality in Patients with Cirrhosis.
Conclusion. The 6MWT distance, MIP, and oxygen consumption are predictors of mortality in patients with cirrhosis. PMID: 27559536 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - August 26, 2016 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Examining the Phenomenon of the Administrative Burden in Health Care, Allied Health, and Respiratory Care
(Source: Journal of Allied Health)
Source: Journal of Allied Health - August 26, 2016 Category: Universities & Medical Training Authors: Heuer, Albert J. Parrott, James Scott Percival, Dreina Kacmarek, Robert M. Source Type: research

High-Intensity Training and Salivary Immunoglobulin A Responses in Professional Top-Level Soccer Players: Effect of Training Intensity
This study aimed (a) to test the hypothesis that salivary immunoglobulin A (s-IgA) would vary with training intensity sessions (low-intensity [LI] vs. high-intensity sessions [HI]) during a traditional training program divided into 4 training periods and (b) to identify key variables (e.g., GPS data, rating of perceived exertion [RPE], and training duration), which could affect s-IgA. Saliva samples of 10 elite professional soccer players were collected (a) before the investigation started to establish the baseline level and (b) before and after each 4 training sessions (LI vs. HI). Training intensity was monitored as inte...
Source: Journal of Strength and Conditioning Research - August 26, 2016 Category: Sports Medicine Tags: Original Research Source Type: research

Pulmonary Rehabilitation Utilization in Older Adults With Chronic Obstructive Pulmonary Disease, 2003 to 2012
CONCLUSIONS: Utilization of PR during the study period increased only 1.1% in these Medicare beneficiaries with COPD and remained low. (Source: Journal of Cardiopulmonary Rehabilitation)
Source: Journal of Cardiopulmonary Rehabilitation - August 26, 2016 Category: Rehabilitation Tags: Pulmonary Rehabilitation Source Type: research

Do lactate levels in the emergency department predict outcome in adult trauma patients? A systematic review
CONCLUSIONS: This review shows that elevated Emergency Department lactate levels are associated with mortality and may be associated with other clinical outcomes in adult trauma patients. We conclude that lactate is a useful marker of outcome in trauma, in addition to current markers of severity. The potential roles of serial lactate measurement and lactate clearance require further research. LEVEL OF EVIDENCE: Systematic review, level III. (Source: The Journal of Trauma: Injury, Infection, and Critical Care)
Source: The Journal of Trauma: Injury, Infection, and Critical Care - August 26, 2016 Category: Orthopaedics Tags: Systematic Reviews Source Type: research

Changes in the prevalence and biofilm formation of Haemophilus influenzae and Haemophilus parainfluenzae from the respiratory microbiota of patients with sarcoidosis
Healthy condition and chronic diseases may be associated with microbiota composition and its properties. The prevalence of respiratory haemophili with respect to their phenotypes including the ability to biofi... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - August 26, 2016 Category: Infectious Diseases Authors: Urszula Kosikowska, Pawe ł Rybojad, Dagmara Stępień–Pyśniak, Anna Żbikowska and Anna Malm Source Type: research

The impact of comorbidities on productivity loss in asthma patients
Health-related productivity loss is an important, yet overlooked, component of the economic burden of disease in asthma patients of a working age. We aimed at evaluating the effect of comorbidities on producti... (Source: Respiratory Research)
Source: Respiratory Research - August 26, 2016 Category: Respiratory Medicine Authors: Solmaz Ehteshami-Afshar, J. Mark FitzGerald, Christopher Carlsten, Hamid Tavakoli, Roxanne Rousseau, Wan Cheng Tan, J. Douglass Rolf and Mohsen Sadatsafavi Source Type: research

Dementia, gait disturbance, and urinary incontinence in a patient with pulmonary sarcoidosis
Hydrocephalus is an uncommon presentation of neurosarcoidosis. We discuss the case of a 67‐year‐old woman with a prior diagnosis of hypothyroidism, systemic hypertension, and lung sarcoidosis who presented with a 1‐month history of progressive impairment of consciousness leading to prostration and loss of sphincter control. At admission, patient was febrile with altered speech and without focalization. Laboratory results showed leucocytosis and mild anaemia. Cerebrospinal fluid (CSF) analysis was characterized by mild elevated protein level, increased cell count, normal glucose and adenosine deaminase (ADA), negative...
Source: Respirology Case Reports - August 26, 2016 Category: Respiratory Medicine Authors: Gonzalo Labarca, Romina Ramirez, Ximena Monsalve, Isabel Mira ‐Avendano Tags: Case Report Source Type: research

Tolerability and efficacy of afatinib at a low starting dosage in 10 elderly or low performance status patients with advanced refractory non-small-cell lung cancer
Conclusions A low starting dosage of afatinib might enable elderly or low PS patients with advanced refractory NSCLC to receive this drug as salvage therapy. (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 26, 2016 Category: Respiratory Medicine Source Type: research

Clinical analysis of patients treated with afatinib for advanced non-small cell lung cancer: A Nagano Lung Cancer Research Group observational study
Conclusions Although the survival benefit with afatinib remains unclear, our observational analysis demonstrated the feasibility of using afatinib for EGFR-mutated NSCLC in clinical practice. In particular, a relatively high level of drug delivery is possible. In addition, a lower BSA may be a predictor of diarrhea in patients treated with afatinib. (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 26, 2016 Category: Respiratory Medicine Source Type: research

Nasal high flow reduces hypercapnia by clearance of anatomical dead space in a COPD patient
In conclusion, NHF assist ventilation through clearance of anatomical dead space, which improves alveolar ventilation. Since the reduction in hypercapnia was similar to that reported with effective NIV treatment NHF may become an alternative to NIV in hypercapnic respiratory failure. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - August 26, 2016 Category: Respiratory Medicine Source Type: research

Retroperitoneal fibrosis with periaortitis: A case report of an unusual form of presentation of granulomatosis with polyangiitis
We present the case of a 74-year-old man with a past history of infrarenal abdominal aortic aneurysm. He consulted for abdominal pain. Cavitating pulmonary nodules and retroperitoneal fibrosis with periaortic alterations were detected on computed tomography. Laboratory investigations revealed that the patient was positive for cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) and necrotising granulomas were observed on biopsies of the lung lesions and retroperitoneal tissue. The patient was diagnosed with GPA and treatment was started with glucocorticoids and immunosuppressive agents, which led to a significant cli...
Source: Respiratory Medicine Case Reports - August 26, 2016 Category: Respiratory Medicine Source Type: research

Respiratory-gated time-of-flight PET/CT during whole-body scan for lung lesions: feasibility in a routine clinical setting and quantitative analysis
ConclusionsRespiratory gating during whole-body scan in routine TOF PET/CT examinations is feasible and can reduce both misregistration and PET image blurring, and improve the SUVmax of lung lesions located primarily in the LL. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - August 26, 2016 Category: Nuclear Medicine Source Type: research

A sneak peek into digital innovations and wearable sensors for cardiac monitoring
AbstractMany mobile phone or tablet applications have been designed to control cardiovascular risk factors (obesity, smoking, sedentary lifestyle, diabetes and hypertension) or to optimize treatment adherence. Some have been shown to be useful but the long-term benefits remain to be demonstrated. Digital stethoscopes make easier the interpretation of abnormal heart sounds, and the development of pocket-sized echo machines may quickly and significantly expand the use of ultrasounds. Daily home monitoring of pulmonary artery pressures with wireless implantable sensors has been shown to be associated with a significant decrea...
Source: Journal of Clinical Monitoring and Computing - August 26, 2016 Category: Information Technology Source Type: research

Utilization of ancillary studies in the cytologic diagnosis of respiratory lesions: The papanicolaou society of cytopathology consensus recommendations for respiratory cytology
The Papanicolaou Society of Cytopathology has developed a set of guidelines for respiratory cytology including indications for sputum examination, bronchial washings and brushings, CT‐guided FNA and endobronchial ultrasound guided fine needle aspiration (EBUS‐FNA), as well as recommendations for classification and criteria, ancillary testing and post‐cytologic diagnosis management and follow‐up. All recommendation documents are based on the expertise of committee members, an extensive literature review, and feedback from presentations at national and international conferences. The guideline documents selectively pr...
Source: Diagnostic Cytopathology - August 26, 2016 Category: Pathology Authors: Lester J. Layfield, Sinchita Roy ‐Chowdhuri, Zubair Baloch, Hormoz Ehya, Kim Geisinger, Susan J. Hsiao, Oscar Lin, Neal I. Lindeman, Michael Roh, Fernando Schmitt, Nikoletta Sidiropoulos, Paul A. VanderLaan Tags: Special Contribution Source Type: research

Dry Powder Inhaler Delivery of Tobramycin in In Vitro Models of Tracheostomized Children
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - August 26, 2016 Category: Respiratory Medicine Authors: Wallace B. Wee Scott Tavernini Andrew R. Martin Israel Amirav Carina Majaesic Warren H. Finlay Source Type: research

The Advantages of Adding Hyaluronic Acid or Mannitol to Hypertonic Saline Inhalation Treatment in Cystic Fibrosis
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - August 26, 2016 Category: Respiratory Medicine Authors: Clizia Cazzarolli Chiara Tartali Ugo Pradal Source Type: research

Physical function after extracorporeal membrane oxygenation in patients pre or post heart transplantation – An observational study
Conclusion Patients requiring ECMO pre or post HTx had impaired physical function at ICU discharge and leg complications were common. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - August 26, 2016 Category: Respiratory Medicine Source Type: research

Pig Abattoir Inspection Data: Can It Be Used for Surveillance Purposes?
In this study we postulate that FSA data could be used for surveillance purposes. To test this we compared FSA data with BPHS (a targeted surveillance system of slaughtered pigs) and laboratory diagnostic scanning surveillance (FarmFile) da ta, from mid-2008 to mid-2012, for respiratory conditions and tail bite lesions in pigs at population level. We also evaluated the agreement/correlation at batch level between FSA and BPHS inspections in four field trials during 2013. Temporal trends and regional differences at population level were described and compared using logistic regression models. Population temporal analysis sh...
Source: PLoS One - August 26, 2016 Category: Biomedical Science Authors: Carla Correia-Gomes Source Type: research

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
We describe a method for the rapid and specific isolation of mitochondria and use it in tandem with a database of predicted mitochondrial metabolites (“MITObolome”) to measure the matrix concentrations of more than 100 metabolites across various states of respiratory chain (RC) function. Disruption of the RC reveals extensive compartmentalization of mitochondrial metabolism and signatures unique to the inhibition of each RC complex. Pyruvate enables the proliferation of RC-deficient cells but has surprisingly limited effects on matrix contents. Interestingly, despite failing to restore matrix NADH/NAD balance, pyruva...
Source: Cell - August 26, 2016 Category: Cytology Source Type: research

Internet-based self-management support for adults with asthma: a qualitative study among patients, general practitioners and practice nurses on barriers to implementation
Conclusions We identified a variety of barriers to implementation of PatientCoach. An effective implementation strategy for internet-based self-management support in asthma care should focus on these barriers. (Source: BMJ Open)
Source: BMJ Open - August 26, 2016 Category: Journals (General) Authors: van Gaalen, J. L., van Bodegom-Vos, L., Bakker, M. J., Snoeck-Stroband, J. B., Sont, J. K. Tags: Open access, General practice / Family practice, Patient-centred medicine, Qualitative research, Respiratory medicine Source Type: research

Programmed Death-1 Inhibition of PI3K/AKT/mTOR Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation.
Abstract Patients with progressive sarcoidosis exhibit increased expression of Programmed-Death-1 (PD-1) on their CD4+ T cells. Upregulation of this marker of T cell exhaustion is associated with a reduction in the proliferative response to T cell receptor (TCR) stimulation, a defect which is reversed by PD-1 pathway blockade. Genome-Wide Association Studies (GWAS) and microarray analyses have correlated signaling downstream from the TCR with sarcoidosis disease severity, but the mechanism is not yet known. Reduced PI3K/Akt expression inhibits proliferation by inhibiting cell cycle progression. To test the hypothe...
Source: American Journal of Respiratory Cell and Molecular Biology - August 26, 2016 Category: Molecular Biology Authors: Celada LJ, Rotsinger JE, Young A, Shaginurova G, Shelton D, Hawkins C, Drake WP Tags: Am J Respir Cell Mol Biol Source Type: research

The effects of suplatast tosilate on acutely dissociated sensory and paratracheal ganglia neurons.
In this study, we investigated the effects of suplatast on acutely dissociated single neurons of sensory and paratracheal ganglia using a patch-clamp technique. Suplatast had little effect on various responses caused by capsaicin, acid, bradykinin, serotonin and adenosine 5'-triphosphate in rat sensory neurons. Suplatast, even at 10-3 M, also did not induce any current at various membrane potentials in rat and guinea pig paratracheal ganglia neurons. Further, acetylcholine- and bradykinin-induced depolarizations were not affected by suplatast. On the other hand, in rat paratracheal ganglia neurons, 10-5 M nicotine-induced ...
Source: Am J Physiol Lung Ce... - August 26, 2016 Category: Respiratory Medicine Authors: Zhou JR, Shirasaki T, Soeda F, Takahama K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Role of IQGAP1 in endothelial barrier enhancement caused by OxPAPC.
This study evaluated the role for the multifunctional Rac1/Cdc42 effector and regulator, IQGAP1, as a molecular transducer of the OxPAPC-mediated EC barrier enhancing signal. IQGAP1 knockdown in endothelial cells by gene-specific siRNA abolished OxPAPC-induced enlargement of VE-cadherin-positive adherens junctions, suppressed peripheral accumulation of actin polymerization regulators, namely cortactin, N-WASP and Arp3, and attenuated remodeling of the peripheral actin cytoskeleton. Inhibition of OxPAPC-induced barrier enhancement by IQGAP1 knockdown was due to suppressed Rac1 and Cdc42 activation. Expression of an IQGAP1 t...
Source: Am J Physiol Lung Ce... - August 26, 2016 Category: Respiratory Medicine Authors: Tian Y, Tian X, Gawlak G, Sarich N, Sacks DB, Birukova AA, Birukov KG Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Age and Small Airway Imaging Abnormalities in Subjects With and Without Airflow in SPIROMICS.
CONCLUSIONS: In never- and ever-smokers without airflow obstruction, aging is associated with increased FVC and CT-defined functional small airway abnormality regardless of respiratory symptoms. PMID: 27564413 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 26, 2016 Category: Respiratory Medicine Authors: Martinez CH, Diaz AA, Meldrum C, Curtis JL, Cooper CB, Pirozzi C, Kanner RE, Paine Iii R, Woodruff PG, Bleecker ER, Hansel NN, Barr RG, Marchetti N, Criner GJ, Kazerooni EA, Hoffman EA, Ross BD, Galban CJ, Cigolle CT, Martinez FJ, Han MK, SPIROMICS Invest Tags: Am J Respir Crit Care Med Source Type: research