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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Immunoglobulin G Subclass Deficiencies in Adult Patients with Chronic Airway Diseases.
In conclusion, IgGSCD is an important PI in the subset of patients with chronic airway diseases who had recurrent upper and lower respiratory infections as they presented with exacerbation-prone phenotypes, decline in lung function, and subsequently poor prognosis. PMID: 27550483 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - August 25, 2016 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Reconstructive transoral laser microsurgery for posterior glottic web with stenosis
ConclusionsRTLM using the PCMAF is a feasible, safe, and effective alternative to open approaches for airway reconstruction for PGWS. This novel transoral technique includes a much simpler endoscopic suturing alternative to knot tying among other new features. It is reproducible and reliable for laryngologists familiar with laryngeal microsurgery. Level of Evidence4. Laryngoscope, 2016 (Source: The Laryngoscope)
Source: The Laryngoscope - August 25, 2016 Category: ENT & OMF Authors: Ihab Atallah, Manjunath M. Krishniah, Ahmad Al Omari, Christian Adrien Righini, Paul F. Castellanos Tags: Laryngology Source Type: research

Recurrent Pneumonia in an Infant
A neonate had respiratory distress requiring endotracheal intubation; videofluoroscopic swallow study demonstrated aspiration with all consistencies, and she hadKlebsiella pneumoniaesepsis and persistent lung collapse. What is your diagnosis? (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - August 25, 2016 Category: ENT & OMF Source Type: research

Drop-out rate among patients treated with omalizumab for severe asthma: Literature review and real-life experience
In patients with asthma, particularly severe asthma, poor adherence to inhaled drugs negatively affects the achievement of disease control. A better adherence rate is expected in the case of injected drugs, su... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 25, 2016 Category: Respiratory Medicine Authors: M. Caminati, G. Senna, G. Stefanizzi, R. Bellamoli, S. Longhi, F. Chieco-Bianchi, G. Guarnieri, S. Tognella, M. Olivieri, C. Micheletto, G. Festi, E. Bertocco, M. Mazza, A. Rossi and A. Vianello Source Type: research

ALK gene copy number gains in non-small-cell lung cancer: prognostic impact and clinico-pathological correlations
This study aimed to evaluate the associati... (Source: Respiratory Research)
Source: Respiratory Research - August 25, 2016 Category: Respiratory Medicine Authors: U. Peretti, R. Ferrara, S. Pilotto, S. Kinspergher, M. Caccese, A. Santo, M. Brunelli, A. Cali ò, L. Carbognin, I. Sperduti, M. Garassino, M. Chilosi, A. Scarpa, G. Tortora and E. Bria Source Type: research

Post-ischemia mdivi-1 treatment protects against ischemia/reperfusion-induced brain injury in a rat model
In conclusion, when given after ischemia and prior to reperfusion, mdivi-1 can protect against brain damage by inhibiting the mitochondria-mediated apoptosis induced by mitochondrial fission. Post-ischemia mdivi-1 treatment might promote I/R-induced mitochondrial biogenesis. (Source: Neuroscience Letters)
Source: Neuroscience Letters - August 25, 2016 Category: Neuroscience Source Type: research

Priming of the neutrophil respiratory burst: role in host defense and inflammation
Summary Neutrophils are the major circulating white blood cells in humans. They play an essential role in host defense against pathogens. In healthy individuals, circulating neutrophils are in a dormant state with very low efficiency of capture and arrest on the quiescent endothelium. Upon infection and subsequent release of pro‐inflammatory mediators, the vascular endothelium signals to circulating neutrophils to roll, adhere, and cross the endothelial barrier. Neutrophils migrate toward the infection site along a gradient of chemo‐attractants, then recognize and engulf the pathogen. To kill this pathogen entrapped in...
Source: Immunological Reviews - August 25, 2016 Category: Allergy & Immunology Authors: Jamel El ‐Benna, Margarita Hurtado‐Nedelec, Viviana  Marzaioli, Jean‐Claude Marie, Marie‐Anne Gougerot‐Pocidalo, Pham My‐Chan Dang Tags: Invited Review Source Type: research

The intimate and controversial relationship between voltage ‐gated proton channels and the phagocyte NADPH oxidase
Summary One of the most fascinating and exciting periods in my scientific career entailed dissecting the symbiotic relationship between two membrane transporters, the Nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase complex and voltage‐gated proton channels (HV1). By the time I entered this field, there had already been substantial progress toward understanding NADPH oxidase, but HV1 were known only to a tiny handful of cognoscenti around the world. Having identified the first proton currents in mammalian cells in 1991, I needed to find a clear function for these molecules if the work was to becom...
Source: Immunological Reviews - August 25, 2016 Category: Allergy & Immunology Authors: Thomas E. DeCoursey Tags: Invited Review Source Type: research

Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation
Summary Neutrophils constitute the first line of cellular defense against invading microorganisms and modulate the subsequent innate and adaptive immune responses. In order to execute a rapid and precise response to infections, neutrophils rely on preformed effector molecules stored in a variety of intracellular granules. Neutrophil granules contain microbicidal factors, the membrane‐bound components of the respiratory burst oxidase, membrane‐bound adhesion molecules, and receptors that facilitate the execution of all neutrophil functions including adhesion, transmigration, phagocytosis, degranulation, and neutrophil e...
Source: Immunological Reviews - August 25, 2016 Category: Allergy & Immunology Authors: Mahalakshmi Ramadass, Sergio D Catz Tags: Invited Review Source Type: research

7th drug hypersensitivity meeting: part one
Table of contentsOral AbstractsO1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TENDaniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir PirmohamedO2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture?Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel YerlyO3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivityRebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, Davi...
Source: Clinical and Translational Allergy - August 25, 2016 Category: Allergy & Immunology Source Type: research

Factors Influencing Diaphragmatic Compound Motor Action Potentials During Cryoballoon Ablation for Atrial Fibrillation
ConclusionDiaphragmatic CMAP amplitude is not affected by stimulus strength or BMI. There is a significant respirophasic decrease in CMAP signal amplitude with inspiration. It is important to be aware of this variation to avoid premature termination of cryoablation.This article is protected by copyright. All rights reserved (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - August 25, 2016 Category: Cardiology Authors: PARIKSHIT S. SHARMA, SANTOSH K. PADALA, J. JENKINS THOMPSON, SAMPATH GUNDA, JAYANTHI N. KONERU, KENNETH A. ELLENBOGEN Tags: Original Article Source Type: research

Pneumonia due to Chlamydia pecorum in a Koala (Phascolarctos cinereus)
This report provides the best evidence to date of chlamydial infection causing pneumonia in a koala, and the first evidence that C. pecorum is capable of infecting the bronchiolar epithelium of the koala. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - August 25, 2016 Category: Pathology Source Type: research

Can treatment with statins have a negative influence on the tolerance of mandibular advancement devices?
ConclusionTreatment with statins can give rise to the appearance of undesirable side effects among patients being treated with oral devices. (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 25, 2016 Category: Respiratory Medicine Source Type: research

Cancer immunotherapy as a promising fourth standard therapy for lung cancer: Beyond 20 years for the development of immunotherapy
Publication date: September 2016 Source:Respiratory Investigation, Volume 54, Issue 5 Author(s): Yasuhiko Nishioka (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 25, 2016 Category: Respiratory Medicine Source Type: research

Efficacy and safety of indacaterol/glycopyrronium in Japanese patients with COPD: Pooled analysis of SHINE and ARISE
Conclusions Compared to tiotropium, IND/GLY provided significant improvements in lung function, health status, and rescue medication use, while having a good safety profile in Japanese patients with moderate-to-severe COPD. (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 25, 2016 Category: Respiratory Medicine Source Type: research

“Cold air” and/or “talking” as cough triggers, a sign for the diagnosis of cough variant asthma
Conclusion “Cold air” and/or “talking” as cough triggers could be signs for the diagnosis of CVA, particularly when FeNO levels are low. (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 25, 2016 Category: Respiratory Medicine Source Type: research

Primary spontaneous pneumothorax due to high bleb burden
We present a case report of a young, male, former-smoker and polysubstance abuser with no prior lung history that developed acute dyspnea at rest and was found to have a large right pneumothorax on chest x-ray. A pig-tail catheter was utilized, but his course was complicated by a recurrent tension pneumothorax. Chest computed tomography (CT) revealed a significant bleb burden and the patient underwent a lung wedge resection with mechanical pleurodesis. What made our case unique were the chest x-rays revealing blebs that could have predicted the patient's recurrent pneumothorax as well as the multiple potential risk factors...
Source: Respiratory Medicine Case Reports - August 25, 2016 Category: Respiratory Medicine Source Type: research

Health in times of uncertainty in the eastern Mediterranean region, 1990 –2013: a systematic analysis for the Global Burden of Disease Study 2013
The objective of this study was to present the burden of diseases, injuries, and risk factors in the eastern Mediterranean region as of 2013. Methods GBD 2013 includes an annual assessment covering 188 countries from 1990 to 2013. The study covers 306 diseases and injuries, 1233 sequelae, and 79 risk factors. Our GBD 2013 analyses included the addition of new data through updated systematic reviews and through the contribution of unpublished data sources from collaborators, an updated version of modelling software, and several improvements in our methods. In this systematic analysis, we use data from GBD 2013 to analyse th...
Source: The Lancet Global Health - August 25, 2016 Category: Global & Universal Source Type: research

Host –pathogen interactions of nontypeable Haemophilus influenzae: from commensal to pathogen
Nontypeable Haemophilus influenzae (NTHi) is a commensal microbe often isolated from the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis media in preschool children, exacerbations in patients suffering from chronic obstructive pulmonary disease, as well as conjunctivitis and bacteremia. Since the introduction of a vaccine against H. influenzae serotype b in the 1990s, the burden of H. influenzae‐related infections has been increasingly dominated by NTHi. Understanding the ability of NTHi to cause infection is currently an expanding area of study. NTHi is able to exert different...
Source: FEBS Letters - August 25, 2016 Category: Biochemistry Authors: Benjamin Luke Duell, Yu ‐Ching Su, Kristian Riesbeck Tags: Review Article Source Type: research

The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10 < sup > + < /sup > T Cells
by Martijn J. Schuijs, Susanne Hartmann, Murray E. Selkirk, Luke B. Roberts, Peter J. M. Openshaw, Corinna Schnoeller Respiratory Syncytial Virus (RSV) is a major pathogen causing low respiratory tract disease (bronchiolitis), primarily in infants. Helminthic infections may alter host immune responses to both helminths and to unrelated immune triggers. For example, we have previously shown that filarial cystatin (AvCystatin/Av17) ameliorates allergic airway inflammation. However, helminthic immunomodulators have so far not been tested in virus-induced disease. We now report that AvCystatin prevents Th2-based immunopatholo...
Source: PLoS One - August 25, 2016 Category: Biomedical Science Authors: Martijn J. Schuijs Source Type: research

Characterization of Staphylococcus aureus isolates from pediatric patients with cystic fibrosis
In this study, we collected sputum and isolated fiftyS. aureus isolates from CF patients with the median age of 9.5  years old. Then we determined the profiles of these isolates by antibiotic susceptibility testing, examining their cytotoxicity and ability to internalize into an epithelial cell line (A549), as well as multiple loci sequencing typing. Predominant CFS. aureus isolates were resistant to penicillin; however, these isolates were sensitive to various antibiotics, such as vancomycin and minocycline. Different CFS. aureus isolates showed distinct cytotoxic activities, and 90  % of CFS. aureus isolates possessed ...
Source: World Journal of Microbiology and Biotechnology - August 25, 2016 Category: Microbiology Source Type: research

Effect of lung-protective ventilation-induced respiratory acidosis on the duration of neuromuscular blockade by rocuronium
ConclusionsLung-protective ventilation-induced respiratory acidosis increased the duration of neuromuscular blockade by rocuronium. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 25, 2016 Category: Anesthesiology Source Type: research

Maternal obesity and childhood wheezing and asthma
The objective of this review is to provide an overview of the most recent evidence regarding the associations between pre-pregnancy overweight/obesity and wheezing and asthma in childhood. Potential mechanisms, mediators and confounding factors involved in these associations are also discussed. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - August 25, 2016 Category: Respiratory Medicine Authors: Franca Rusconi, Maja Popovic Source Type: research

Coexistence of asthma and polycystic ovary syndrome: A concise review
Asthma may be associated with polycystic ovary syndrome (PCOS), and possibly patients with PCOS have a more severe type of asthma. The purpose of this systematic literature review is to summarize evidence of a coexistense of PCOS and asthma using the available literature. The search was completed on 01.01.2016. English language articles were retrieved using the search terms ‘Asthma’ AND ‘PCOS’, ‘Asthma’ AND ‘systemic inflammation’, ‘Asthma’ AND ‘metabolic syndrome’, ‘asthma’ AND ‘gynaecology’, ‘PCOS’ AND ‘systemic inflammation’, ‘PCOS’ AND ‘metabolic syndrome’, ‘PCOS’ AND...
Source: Respiratory Medicine - August 25, 2016 Category: Respiratory Medicine Authors: Louise Zierau, Elisabeth Juul Gade, Svend Lindenberg, Vibeke Backer, Simon Francis Thomsen Tags: Review article Source Type: research

Diastolic pulmonary gradient predicts outcomes in group 1 pulmonary hypertension (analysis of the NIH primary pulmonary hypertension registry)
Diastolic pulmonary gradient (DPG), calculated as the difference between pulmonary artery diastolic pressure and mean pulmonary capillary wedge pressure  ≥ 7 mmHg is associated with pulmonary vascular disease and portends poor prognosis in heart failure (HF). The prognostic relevance of DPG in group 1 pulmonary hypertension (PH) is uncertain. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 25, 2016 Category: Respiratory Medicine Authors: Sula Mazimba, Eliany Mejia-Lopez, George Black, Jamie L. Kennedy, James Bergin, Jose A. Tallaj, Mohammad Abuannadi, Andrew D. Mihalek, Kenneth C. Bilchick Source Type: research

Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study
Exercise-induced oxygen desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics.Data from 2050 COPD patients (age: 63.3  ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several...
Source: Respiratory Medicine - August 25, 2016 Category: Respiratory Medicine Authors: Vasileios Andrianopoulos, Bartolome R. Celli, Frits M.E. Franssen, Victor M. Pinto-Plata, Peter M.A. Calverley, Lowie E.G.W. Vanfleteren, Ioannis Vogiatzis, J ørgen Vestbo, Alvar Agusti, Per S. Bakke, Stephen I. Rennard, William MacNee, Ruth Tal-Singer, Source Type: research

A retrospective epidemiological analysis of risk factors for a primary necropsy diagnosis of bovine respiratory disease
Publication date: Available online 25 August 2016 Source:Preventive Veterinary Medicine Author(s): G.M. Murray, J.P. Cassidy, T.A. Clegg, J.A. Tratalos, J. McClure, R.G.O. Neill, D.J. Sammin, M.J. Casey, M. McElroy, B. Earley, N. Bourke, S.J. More (Source: Preventive Veterinary Medicine)
Source: Preventive Veterinary Medicine - August 25, 2016 Category: Veterinary Research Source Type: research

Inhibition of CD8(+) T cells and elimination of myeloid cells by CD4(+) Foxp3(-) T regulatory type 1 cells in acute respiratory distress syndrome.
This article is protected by copyright. All rights reserved. PMID: 27558304 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 25, 2016 Category: Drugs & Pharmacology Authors: Li GG, Cao YH, Run Y, Xu RX, Zheng ZD Tags: Clin Exp Pharmacol Physiol Source Type: research

Resonance as the Mechanism of Daytime Periodic Breathing in Patients with Heart Failure.
CONCLUSIONS: Our study elucidates the mechanism underlying daytime ventilatory oscillations in heart failure, and provides a means to measure and interpret these oscillations to reveal the underlying chemoreflex hypersensitivity and reduced stability that foretells mortality in this population. PMID: 27559818 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 25, 2016 Category: Respiratory Medicine Authors: Sands SA, Mebrate Y, Edwards BA, Nemati S, Manisty CH, Desai AS, Wellman A, Willson K, Francis DP, Butler JP, Malhotra A Tags: Am J Respir Crit Care Med Source Type: research

Epigenetic Regulation of Caveolin-1 Gene Expression in Lung Fibroblasts.
CONCLUSION: Our data indicate that Cav-1 gene silencing in lung fibroblasts is actively regulated by epigenetic mechanisms that involve histone modifications, in particular H3K4Me3, whereas DNA methylation does not appear to be a primary mechanism. These findings support therapeutic strategies that target histone modifications to restore Cav-1 expression in fibroblasts participating in pathogenic tissue remodeling. PMID: 27560128 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - August 25, 2016 Category: Respiratory Medicine Authors: Sanders YY, Liu H, Scruggs AM, Duncan SR, Huang SK, Thannickal VJ Tags: Am J Respir Cell Mol Biol Source Type: research

Shelterin TPP1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirt1 Deacetylase in Chronic Obstructive Pulmonary Disease.
Abstract Lung cellular senescence and inflammatory response are the key events in the pathogenesis of chronic obstructive pulmonary disease (COPD) where cigarette smoke (CS) is the main etiological factor. Telomere dysfunction is induced by either critical shortening or disruption of the shelterin complex, leading to cellular senescence. However, it remains unknown whether disruption of shelterin complex is responsible for CS-induced lung cellular senescence. Here we show that TPP1 levels are reduced on telomeres in mouse lungs with emphysema, as well as in lungs from smokers and COPD patients. This is associated ...
Source: Am J Respir Cell Mol... - August 25, 2016 Category: Respiratory Medicine Authors: Ahmad T, Sundar IK, Tormos AM, Lerner CA, Gerloff J, Yao H, Rahman I Tags: Am J Respir Cell Mol Biol Source Type: research

Sphingobacterium chuzhouense sp. nov., isolated from farmland soil.
Abstract A novel Gram-staining-negative bacterial, designated DH-5T, was isolated from a farmland soil in Chuzhou, Anhui province, China. Cells of strain DH-5T were aerobic, non-motile, non-spore-forming and rod-shaped. The organism grew at 20-40°C, pH 6.0-9.0 and 0-5% NaCl (w/v). The DNA G+C content was 42.8 mol%. The major fatty acids (> 5%) were iso-C15:0, summed feature 3 (C16:1 7c and/or iso-C16:1 6c), iso-C17:0 3-OH and C16:0. The respiratory quinone was MK-7, and the major polar lipids were phosphatidylethanolamine and phosphoglycolipid. Phylogenetic analysis based on 16S rRNA gene sequences showed that...
Source: International Journal of Systematic and Evolutionary Microbiology - August 25, 2016 Category: Microbiology Authors: Wang X, Zhang CF, Yu X, Hu G, Yang HX, Zhang YK, Zhu SJ, Jin W, Zhang H, Hong Q Tags: Int J Syst Evol Microbiol Source Type: research

Pelobium manganitolerans gen. nov., sp. nov., isolated from sludge of a manganese mine.
Abstract A Gram-staining-negative, rod-shaped, motile by gliding and facultative anaerobic bacterial strain, YS-25T, was isolated from sludge of a manganese mine. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain YS-25T formed a single branch within the strains of family Sphingobacteriaceae and showed low similarities to Pedobacter arcticus CCTCC AB 2010223T (91.7%), Pedobacter zeaxanthinifaciens TDMA-5T (91.5%), Pedobacter terricola DS-45T (90.9%), Pedobacter ureilyticus THG-T11T (90.9%), Pseudopedobacter beijingensis MCCC 1A01299T (90.8%) and Pedobacter heparinus CCTCC AB 209030T (88.5%...
Source: International Journal of Systematic and Evolutionary Microbiology - August 25, 2016 Category: Microbiology Authors: Xia X, Wu S, Han Y, Liao S, Wang G Tags: Int J Syst Evol Microbiol Source Type: research

Sphingoaurantiacus capsulatus sp. nov., isolated from mountain soil, and emended description of the genus Sphingoaurantiacus.
Abstract A novel Gram-staining-negative, strictly aerobic, non-motile, rod-shaped, capsule-forming bacterium, designated strain YLT33T that forms orange-red colonies was isolated from mountain cliff soil located in Enshi Grand Canyon, southwest China. Growth occurred at 4-35 °C (optimum 28 °C) and at pH 6.0-10.0 (optimum 7.0). It showed maximum (99.3 %) 16S rRNA gene sequence similarity and formed a monophyletic clade with Sphingoaurantiacus polygranulatus MC 3718T (= CCTCC 2014274T). The DNA G+C content was 68.5 mol % and the strain YLT33T showed 50.5 % DNA-DNA relatedness to S. polygranulatus MC 3718T. The maj...
Source: International Journal of Systematic and Evolutionary Microbiology - August 25, 2016 Category: Microbiology Authors: Tan Y, Wang Y, Wang D, Wang G, Zheng S Tags: Int J Syst Evol Microbiol Source Type: research

Physician's knowledge, attitudes, and practices regarding seasonal influenza, pandemic influenza, and highly pathogenic avian influenza A (H5N1) virus infections of humans in Indonesia
This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - August 24, 2016 Category: Virology Authors: M Amalya, A D Iuliano, Y Wahyuningrum, C Y Praptiningsih, K E Lafond, A D Storms, G Samaan, I Ariawan, N Soeharno, J Kreslake, D Storey, T M Uyeki Tags: Original Article Source Type: research

Secukinumab for the Treatment of Psoriatic Arthritis.
Authors: Baronaite Hansen R, Kavanaugh A Abstract INTRODUCTION: Secukinumab (Cosentyx) is an interleukin-17A (IL-17A) inhibitor administered subcutaneously. Through 2016, it had received approval in a number of countries, including the USA, Japan and in the EU for the treatment of plaque psoriasis, psoriatic arthritis (PsA) and ankylosing spondylitis (AS). AREAS COVERED: This review addresses the mechanism of action, efficacy and safety of secukinumab observed in clinical studies of patients with PsA. Data from recent studies of secukinumab in psoriasis, PsA and AS are included. Expert Commentary: Secukinumab a...
Source: Expert Review of Clinical Immunology - August 24, 2016 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Risk stratification model to detect early pulmonary disease in infants with cystic fibrosis diagnosed by newborn screening
ConclusionWe combined socioeconomic and clinical data to risk‐stratify CF infants for early‐onset lung disease as quantified by iPFT. Our model showed significant differences in infant pulmonary function across risk groups. The developed tool offers an easily available, inexpensive, and non‐invasive way to assess risk of respiratory decline in CF infants and identify those meriting targeted therapeutic attention. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - August 24, 2016 Category: Respiratory Medicine Authors: Lacrecia J. Britton, Gabriela R. Oates, Robert A. Oster, Staci T. Self, Robert B. Troxler, Wynton C. Hoover, Hector H. Gutierrez, William T. Harris Tags: Original Article Source Type: research

Molecular testing increases detection of potential pathogens of acute gastroenteritis —now for the interpretation?
There is no question that new capabilities in molecular diagnostic testing for infectious diseases have advanced clinical care tremendously. Ability to detect viruses and bacteria in normally sterile body sites, such as the central nervous system and bloodstream, are extremely helpful. Molecular methods also have advanced our understanding of pathogen-specific burdens of respiratory tract and other infections, a necessary first step in considering potential development of vaccines for prevention. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - August 24, 2016 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research