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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Physiological responses during exercise with video games in patients with cystic fibrosis: A systematic review
This study aimed to assess the literature describing whether video games generate a physiological response similar to the exercise intensity needed for training in CF. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 21, 2016 Category: Respiratory Medicine Authors: Raquel Pinto Carbonera, Fernanda Maria Vendrusculo, M árcio Vinícius Fagundes Donadio Tags: Review article Source Type: research

Molecular mechanisms underlying hyperoxia acute lung injury
The management of acute hypoxemic respiratory failure frequently includes the use of supraphysiological fractions of inspired oxygen (FiO2), which can be beneficial in the short-term but not without risks in the long-term, causing acute lung injury (ALI). Over the last few years, much attention has been devoted to the intracellular signaling transduction pathways that lead to hyperoxia-induced cell damage, particularly MAP kinase cascades. Identification of involved signaling molecules and understanding of the regulation of the main signal transduction pathways might provide the basis for improving the outcome of patients ...
Source: Respiratory Medicine - August 21, 2016 Category: Respiratory Medicine Authors: Francisca Dias-Freitas, Catarina Metelo-Coimbra, Roberto Roncon-Albuquerque Tags: Review article Source Type: research

Psychiatric history, post-discharge distress, and personality characteristics among incident female cases of takotsubo cardiomyopathy: A case –control study
Conclusions Preadmission anxiety, but not depression, was associated with the occurrence of TC. High distress and PTSD symptoms post-discharge indicate that TC women may be at risk for poor psychological adjustment. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - August 21, 2016 Category: Respiratory Medicine Source Type: research

Think twice – Diagnostic delay in a patient with acute chest pain
We present a case of acute chest pain in a 58-year-old male with severe asthma, which regressed after sublingual administration of nitroglycerine. At the time of hospital admission, there were non-specific ST-changes on the ecg, coronary enzymes were increased, and the patient was concluded to have a non-ST-elevation myocardial infarction, and treated as such. A subacute cardiac catherization showed no signs of significant coronary stenosis. During the next days, there was increasing pain and reduced strength in both feet. Paraclinical imaging and neurological examinations could not explain the symptoms, and physiotherapy ...
Source: Respiratory Medicine Case Reports - August 21, 2016 Category: Respiratory Medicine Source Type: research

Inspiratory fraction as a marker of skeletal muscle dysfunction in patients with COPD
Conclusion IC/TLC≤25% is associated with reduced maximal strength and peak power output of the lower extremities. IC/TLC≤25% may have an important clinical relevance as an index to determine peripheral muscle dysfunction. (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - August 21, 2016 Category: Respiratory Medicine Source Type: research

Effect of a home-based intervention by trained community health nurses on immunization rates, exclusive breastfeeding, growth parameters, and hospitalizations for respiratory and diarrheal illness – a pilot randomized controlled trial
Publication date: May–June 2016 Source:Annals of Global Health, Volume 82, Issue 3 Author(s): Vasanthan Kuppuswamy, Sarah Logan, Janani Sridhar, Elizabeth O’Brien, Deepa Ranganathan, Kalpana Manthiram, Athi Narayan, Andrea Summer (Source: Annals of Global Health)
Source: Annals of Global Health - August 21, 2016 Category: Global & Universal Source Type: research

Letter to Editor: Application of neuroplasticity theory through the use of the Feldenkrais Method with a runner with scoliosis and lower quarter pain: Additional respiratory mechanic principle, implication of the Feldenkrais method for clinical practice in neuro-musculoskeletal rehabilitation
We read with much interest the paper titled “Application of neuroplasticity theory through the use of the Feldenkrais Method with a runner with scoliosis and hip and lumbar pain: A case report” by LK Myers, 2016. This is an interesting case study that highlight the importance of the neuroplasticity theory for the Feldenkrais Method (FM) o n musculoskeletal condition (Myers, 2016). This case study reveals that the FM method could be regarded as an alternate therapy in musculoskeletal rehabilitation (Henry et al., 2016). (Source: Journal of Bodywork and Movement Therapies)
Source: Journal of Bodywork and Movement Therapies - August 21, 2016 Category: Physiotherapy Authors: Vikram Mohan, Aatit Paungmali, Patraporn Sitilertpisan Source Type: research

RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine
Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections in children, yet no vaccine is available. The sole licensed preventive treatment against RSV is composed of a monoclonal neutralizing antibody (palivizumab), which targets a conformational epitope located on the fusion protein (F). Palivizumab reduces the burden of bronchiolitis but does not prevent infection. Thus, the development of RSV vaccines remains a priority. We previously evaluated nanorings formed by RSV nucleoprotein (N) as an RSV vaccine, as well as an immunostimulatory carrier for heterologous antigens. (Source: Nanomedicine...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - August 21, 2016 Category: Nanotechnology Authors: Pierre-Louis Herv é, Charlotte Deloizy, Delphyne Descamps, Marie-Anne Rameix-Welti, Jenna Fix, Jason S. McLellan, Jean-François Eléouët, Sabine Riffault Source Type: research

New perspectives in the treatment of obstructive sleep apnea –hypopnea syndrome
Conclusions Although a fully effective treatment is not yet available, a combination of strategies from an interdisciplinary perspective can enhance the quality of life of patients. It is expected that in the coming years, the scientific and technological advances will allow for the implementation of a treatment protocol that is able to directly address the etiological processes to reduce their prevalence. (Source: Colombian Journal of Anesthesiology)
Source: Colombian Journal of Anesthesiology - August 21, 2016 Category: Anesthesiology Source Type: research

Characteristics of and Predictors for Apnea and Clinical Interventions During Procedural Sedation
Conclusion Alterations in etco 2 predicted apnea along a specific time course. Alterations in SpO2, apnea, and propofol use predicted clinical interventions. Increasing age predicted both apnea and clinical intervention. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - August 21, 2016 Category: Emergency Medicine Source Type: research

Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells.
Authors: Ippolito L, Marini A, Cavallini L, Morandi A, Pietrovito L, Pintus G, Giannoni E, Schrader T, Puhr M, Chiarugi P, Taddei ML Abstract Drug resistance of cancer cells is recognized as the primary cause of failure of chemotherapeutic treatment in most human cancers. Growing evidences support the idea that deregulated cellular metabolism is linked to such resistance. Indeed, both components of the glycolytic and mitochondrial pathways are involved in altered metabolism linked to chemoresistance of several cancers. Here we investigated the drug-induced metabolic adaptations able to confer advantages to docetaxe...
Source: Oncotarget - August 20, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Essential Oil from Origanum vulgare Completely Inhibits the Growth of Multidrug-Resistant Cystic Fibrosis Pathogens.
Authors: Pesavento G, Maggini V, Maida I, Lo Nostro A, Calonico C, Sassoli C, Perrin E, Fondi M, Mengoni A, Chiellini C, Vannacci A, Gallo E, Gori L, Bogani P, Bilia AR, Campana S, Ravenni N, Dolce D, Firenzuoli F, Fani R Abstract Essential oils (EOs) are known to inhibit the growth of a wide range of microorganisms. Particularly interesting is the possible use of EOs to treat multidrug-resistant cystic fibrosis (CF) pathogens. We tested the essential oil (EO) from Origanum vulgare for in vitro antimicrobial activity, against three of the major human opportunistic pathogens responsible for respiratory infections in...
Source: Natural Product Communications - August 20, 2016 Category: Biochemistry Tags: Nat Prod Commun Source Type: research

Antiviral activity of aspirin against RNA viruses of the respiratory tract – an in vitro study
ConclusionsThese data demonstrate a specific antiviral activity of aspirin against influenza A virus and HRV. The mode of action against rhinoviruses is still unknown and requires further investigation, as does the possibility of aspirin being effective in vivo to treat the common cold.This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - August 20, 2016 Category: Virology Authors: Bernadette Glatthaar ‐Saalmüller, Kerstin H. Mair, Armin Saalmüller Tags: Original Article Source Type: research

Comparison of Cardiorespiratory Demand and Rate of Perceived Exertion During Propulsion in a Natural Environment With and Without the Use of a Mobility Assistance Dog in Manual Wheelchair Users
Conclusions: A trained MAD decreases cardiorespiratory demand and rate of perceived exertion during MWC propulsion on a 630-m course among experienced MWC users with SCI. Trained MADs represent a valuable mobility assistive technology option for MWC users. (Source: American Journal of Physical Medicine and Rehabilitation)
Source: American Journal of Physical Medicine and Rehabilitation - August 20, 2016 Category: Rehabilitation Tags: Original Research Articles Source Type: research

Respiratory Allergic Disorders
Allergic asthma refers to a chronic reversible bronchoconstriction influenced by an allergic trigger, leading to symptoms of cough, wheezing, shortness of breath, and chest tightness. Allergic bronchopulmonary aspergillosis is a complex hypersensitivity reaction, often in patients with asthma or cystic fibrosis, occurring when bronchi become colonized by Aspergillus species. The clinical picture is dominated by asthma complicated by recurrent episodes of bronchial obstruction, fever, malaise, mucus production, and peripheral blood eosinophilia. Hypersensitivity pneumonitis is a syndrome associated with lung inflammation fr...
Source: Primary Care: Clinics in Office Practice - August 20, 2016 Category: Primary Care Authors: Jason Raymond Woloski, Skye Heston, Sheyla Pamela Escobedo Calderon Source Type: research

Gastrointestinal Neoplasia: Current Perspectives and Emerging Frontiers
Gastrointestinal (GI) neoplasias present a substantial challenge to global public health, with recent data demonstrating that esophageal, gastric, colorectal, and pancreatic malignancies account for more than 3.1 million new and 2.1 million fatal cases per year.1 In the United States, 2016 estimates indicate that incident cancers of the digestive system (304,930) will outnumber all other sites, including the genital system (297,530), respiratory system (243,820), and breast (249,260).2 Encouragingly, favorable trends have been observed with respect to both incidence and mortality rates for many site-specific GI malignancie...
Source: Gastroenterology Clinics of North America - August 20, 2016 Category: Gastroenterology Authors: Paul J. Limburg, Dan A. Dixon Tags: Preface Source Type: research

CDC Grand Rounds: Public Health Strategies to Prevent Preterm Birth.
Abstract Preterm birth (delivery before 37 weeks and 0/7 days of gestation) is a leading cause of infant morbidity and mortality in the United States. In 2013, 11.4% of the nearly 4 million U.S. live births were preterm; however, 36% of the 8,470 infant deaths were attributed to preterm birth (1). Infants born at earlier gestational ages, especially <32 0/7 weeks, have the highest mortality (Figure) and morbidity rates. Morbidity associated with preterm birth includes respiratory distress syndrome, necrotizing enterocolitis, and intraventricular hemorrhage; longer-term consequences include developmental delay a...
Source: MMWR Morb Mortal Wkl... - August 20, 2016 Category: Epidemiology Authors: Shapiro-Mendoza CK, Barfield WD, Henderson Z, James A, Howse JL, Iskander J, Thorpe PG Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Diagnosis and surgical management of non-cerebral coenurosis ( Taenia gaigeri ) in local Black Bengal goat of Tripura: report of six cases
AbstractSix cases of coenurosis were reported in a local Black Bengal goat within the age group of 6  months to 1 and half years with the complaint of swelling present on the body surfaces at different anatomical sites. On palpation, the swelling was non-painful and fluctuating uniformly under the skin. All the animals exhibited almost similar signs and symptoms except for three animals which had mild gastro-intestinal problems. All the clinical parameters (heart rate, respiratory rate and rectal temperature) and blood haemoglobin levels (range 10–12 g %) were within the normal physiological limits. After sedation and...
Source: Journal of Parasitic Diseases - August 20, 2016 Category: Parasitology Source Type: research

Paravertebral pseudotumor in patient with hereditary spherocytosis.
Abstract As a rare complication in chronic anemic states, the extramedullary hematopoiesis may provide diagnostic and therapeutic challenge. Caused by the insufficiency of the bone marrow with reactivation of quiescent erythropoietic sites, this condition may vary its presentation as a simple radiologic finding to a spontaneous massive haemothorax. In this paper, we report the case of a 61-years-old female patient with hereditary spherocitosys and paravertebral masses, focusing on clinical and radiological findings in CT and MRI to conclude the tumors etiology and provide adequate care. PMID: 27536548 [PubMed...
Source: Respiratory Care - August 20, 2016 Category: Respiratory Medicine Authors: Rabelo LM, Vieira VL, Dos Santos GR, Heimbecker G, Escuissato DL Tags: Respir Med Case Rep Source Type: research

Cardiac autonomic function in patients with acute exacerbation of chronic obstructive pulmonary disease with and without ventricular tachycardia
Autonomic dysfunction in patients with chronic obstructive pulmonary disease (COPD) may increase the risks of arrhythmia and sudden death. We studied cardiac autonomic function in patients with acute exacerbat... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 20, 2016 Category: Respiratory Medicine Authors: Xingde Wang, Zhaohua Jiang, Bin Chen, Li Zhou, Zhibin Kong, Sheng Zuo, Hua Liu and Shaojun Yin Source Type: research

Implementation of 'matrix support' (collaborative care) to reduce asthma and COPD referrals and improve primary care management in Brazil: a pilot observational study.
Abstract Asthma and chronic obstructive pulmonary disease (COPD) are leading causes of hospitalisation and death in the city of Sao Bernardo do Campo. The municipality had difficulties in sustaining a pulmonology specialist team. Local policy has strengthened the knowledge of the primary care teams to improve the management of these diseases. Our aim is to pilot the implementation of an educational intervention based on collaborative care focused on reducing respiratory-related referrals. We implemented 'matrix support': a Brazilian collaborative educational intervention promoting specialist training and support f...
Source: Primary Care - August 20, 2016 Category: Primary Care Authors: Martins SM, Salibe-Filho W, Tonioli LP, Pfingesten LE, Braz PD, McDonnell J, Williams S, do Carmo D, de Sousa JC, Pinnock H, Stelmach R Tags: NPJ Prim Care Respir Med Source Type: research

Viral bronchiolitis
Publication date: Available online 20 August 2016 Source:The Lancet Author(s): Todd A Florin, Amy C Plint, Joseph J Zorc Viral bronchiolitis is a common clinical syndrome affecting infants and young children. Concern about its associated morbidity and cost has led to a large body of research that has been summarised in systematic reviews and integrated into clinical practice guidelines in several countries. The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children presenting with the typical clinical syndrome of viral upper respiratory in...
Source: The Lancet - August 20, 2016 Category: Journals (General) Source Type: research

A dynamic compartmental model for the Middle East respiratory syndrome outbreak in the Republic of Korea: A retrospective analysis on control interventions and superspreading events
Publication date: 7 November 2016 Source:Journal of Theoretical Biology, Volume 408 Author(s): Jonggul Lee, Gerardo Chowell, Eunok Jung The 2015 Middle East respiratory syndrome (MERS) outbreak in the Republic of Korea has provided an opportunity to improve our understanding of the spread of MERS linked to healthcare settings. Here we designed a dynamic transmission model to analyze the MERS outbreak in the Republic of Korea based on confirmed cases reported during the period May 20–July 4, 2015. Our model explicitly incorporates superspreading events and time-dependent transmission and isolation rates. Our model was ab...
Source: Journal of Theoretical Biology - August 20, 2016 Category: Biology Source Type: research

Interaction Between Allergy and Middle Ear Infection
AbstractPurpose of ReviewRecent studies have attempted to identify interactions among the causes of otitis media with effusion (OME). This review discusses the interaction between allergy and infection with regard to host and environmental factors in terms of the development of OME.Recent FindingsProtection of the upper airway against microbial invasion requires active interaction between the defense mechanisms of the respiratory epithelium, including innate and adaptive immunity, and mechanical factors. The impairment of these defenses due to allergy and/or increased bacterial resistance may lead to increased susceptibili...
Source: Current Allergy and Asthma Reports - August 20, 2016 Category: Allergy & Immunology Source Type: research

Utility and outcomes of hydroxocobalamin use in smoke inhalation patients
House fires account for 3200 deaths and 40,000 injuries undergoing hospitalization in the United States each year [1]. Approximately 60 –80% of these deaths involve smoke inhalation and elevated cyanide levels are frequently found in victims of closed- spaced fires, with the risk of death being directly related to the amount of cyanide exposure [2,3]. Manifestations of cyanide toxicity can range from confusion, headache, nausea an d vomiting to seizures, bradycardia, hypotension, and respiratory or cardiac arrest [4,5]. (Source: Burns : Journal of the International Society for Burn Injuries)
Source: Burns : Journal of the International Society for Burn Injuries - August 20, 2016 Category: Cosmetic Surgery Authors: Lyly Nguyen, Ashkan Afshari, Steven A. Kahn, Stuart McGrane, Blair Summitt Source Type: research

Steven Johnson Syndrome and Toxic Epidermal Necrolysis in a burn unit: A 15-year experience
The diffuse epidermal exfoliation seen in Steven Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) is similar to skin loss in second degree burns, and therefore many of these patients are referred for treatment at burn centers. The epithelial loss induced by these syndromes underlies their high morbidity and mortality as it predisposes the patient to bacterial and fungal infections as well as respiratory, gastrointestinal, nutritional and ocular complications [1]. Treatment can differ markedly from center to center, but most authors agree that optimal outcomes are achieved through early transfer to a burn center,...
Source: Burns : Journal of the International Society for Burn Injuries - August 20, 2016 Category: Cosmetic Surgery Authors: M. McCullough, M. Burg, E. Lin, D. Peng, W. Garner Source Type: research

Ten-year Single Center Experience of Pulmonary Carcinoid Tumors and Diagnostic Yield of Bronchoscopic Biopsy
ConclusionThe diagnosis of pulmonary carcinoid tumors via bronchoscopic biopsy is safe and effective, and bronchoscopy is recommended as the initial diagnostic modality for these tumors. (Source: Lung)
Source: Lung - August 20, 2016 Category: Respiratory Medicine Source Type: research

Prevalence of elevated liver enzymes in children with cystic fibrosis diagnosed by newborn screen
Prevalence and risks for elevated liver enzymes have not been studied systematically in children with CF identified by newborn screen. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - August 20, 2016 Category: Respiratory Medicine Authors: Samantha A. Woodruff, Marci K. Sontag, Frank J. Accurso, Ronald J. Sokol, Michael R. Narkewicz Tags: Original Article Source Type: research

Pharmacokinetics and Dosing of Anti-infective Drugs in Patients on Extracorporeal Membrane Oxygenation: A Review of the Current Literature.
Abstract PURPOSE: Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary bypass device that is used to temporarily support the most critically ill of patients with respiratory and/or cardiac failure. Infection and its sequelae may be an indication for ECMO or infections may be acquired while on ECMO and are associated with a mortality >50%. Effective therapy requires optimal dosing. However, optimal dosing can be different in patients on ECMO because the ECMO circuit can alter drug pharmacokinetics. This review assessed the current literature for pharmacokinetic data and subsequent dosing recommendatio...
Source: Clinical Therapeutics - August 20, 2016 Category: Drugs & Pharmacology Authors: Sherwin J, Heath T, Watt K Tags: Clin Ther Source Type: research

Insights from the German Compassionate Use Program of Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis
Background: Nintedanib is approved for the treatment of idiopathic pulmonary fibrosis (IPF) and has been shown to slow disease progression by reducing annual lung function decline.Objective: To evaluate the results of a large cohort of IPF patients treated with nintedanib within a compassionate use program (CUP) in Germany (9 centers).Methods: Patients ( ≥40 years) were required to have a confirmed diagnosis of IPF, a forced vital capacity (FVC) ≥50% predicted (pred.) and a carbon monoxide diffusing capacity (DLCO) 30-79% pred. and not to be eligible for pirfenidone treatment. Clinical data, pulmonary function tests an...
Source: Respiration - August 19, 2016 Category: Respiratory Medicine Source Type: research

Neonatal experiences with ethanol intoxication modify respiratory and thermoregulatory plasticity and affect subsequent ethanol intake in rats
Abstract Different studies have focused on the deleterious consequences of binge‐like or chronic exposure to ethanol during the brain growth spurt period (third human gestational trimester) that in the rat corresponds to postnatal days (PDs) 3–10. The present study analyzed behavioral and physiological disruptions caused by relatively brief binge‐like exposures (PDs 3, 5, and 7) with an ethanol dose lower (3.0 g/kg) than those frequently employed to examine teratological effects during this stage in development. At PD 9, pups were exposed to ethanol doses ranging between .0–3.0 g/kg and tested in terms of breat...
Source: Developmental Psychobiology - August 19, 2016 Category: Psychiatry & Psychology Authors: Mar ía Belén Acevedo, Ana Fabiola Macchione, Florencia Anunziata, Olga Beatriz Haymal, Juan Carlos Molina Tags: Research Article Source Type: research

Finite-time Lyapunov exponent-based analysis for compressible flows
The finite-time Lyapunov exponent (FTLE) technique has shown substantial success in analyzing incompressibleflows by capturing the dynamics ofcoherent structures. Recent applications include river and oceanflow patterns, respiratory tract dynamics, and bio-inspired propulsors. In the present work, we extendFTLE to thecompressible flow regime so thatcoherent structures, which travel at convective speeds, can be associated withwaves traveling at acoustic speeds. This is particularly helpful in the study ofjet acoustics. We first show that with a suitable choice of integration time interval,FTLE can extractwave dynamics from ...
Source: Chaos - August 19, 2016 Category: Physics Authors: D. R. Gonz ález, R. L. Speth, D. V. Gaitonde and M. J. Lewis Source Type: research

Qualitative Analysis of Surveyed Emergency Responders and the Identified Factors That Affect First Stage of Primary Triage Decision-Making of Mass Casualty Incidents
CONCLUSION Based upon this survey analysis, respondents both with and without direct disaster triage experience identified and ranked triage attributes that support the MUCC guidelines. What appears to best support a balanced disaster mass casualty triage system and considered the most important factors among the surveyed respondents are ‘neurological/cardiovascular’ condition, ‘resource availability’, and the personal attribute of ‘gut instinct’. In addition, decision making in primary triage of a MCI scenario is multifactorial and encompasses life saving interventions, patient mobility, situational instincts ...
Source: PLOS Currents Disasters - August 19, 2016 Category: Global & Universal Authors: Kelly Klein Source Type: research

Rg3 Improves Mitochondrial Function and the Expression of Key Genes Involved in Mitochondrial Biogenesis in C2C12 Myotubes.
CONCLUSION: Our results suggest that Rg3 improves mitochondrial function and the expression of key genes involved in mitochondrial biogenesis, leading to an improvement in insulin resistance in skeletal muscle. Rg3 may have the potential to be developed as an anti-hyperglycemic agent. PMID: 27535645 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - August 19, 2016 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Repositioning 'old' drugs to treat rare diseases: arguing from the mechanism of action.
Authors: Drent M, Bast A, Bootsma HP, Deneer V PMID: 27537726 [PubMed - as supplied by publisher] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Successful management of acute respiratory failure in an Idiopathic Pulmonary Fibrosis patient using an extracorporeal carbon dioxide removal system.
Authors: Vianello A, Arcaro G, Paladini L, Iovino S Abstract Patients with Idiopathic Pulmonary Fibrosis (IPF) requiring Invasive Mechanical Ventilation (IMV) following unsuccessful treatment with Non-Invasive Ventilation (NIV) have a high mortality rate. IMV is, moreover, an independent predictor of poor outcome during the post-transplantation period in patients on waiting lists for Lung Transplantation (LT). Here we describe the successful management of an IPF patient with acute respiratory failure (ARF) using a pump-assisted veno-venous system for extracorporeal CO2 removal (ECCO2R) (ProLUNG® system) as an alte...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Extensive pulmonary sarcoid reaction in a patient with BMPR-2 associated idiopathic pulmonary arterial hypertension.
We describe a case of a 35-year-old woman with idiopathic pulmonary arterial hypertension (IPAH) and a novel BMPR2 mutation, who underwent a successful lung transplantation.  Extensive granulomatous inflammation was seen in the resected lungs. The granulomatous inflammation found in the histology supports  a sarcoid-like reaction due to pulmonary hypertension in the context of the BMPR2 mutation. PMID: 27537724 [PubMed - as supplied by publisher] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sarcoidosis during etanercept treatment for rheumatoid arthritis in women with a history of bilateral oophorectomy.
Authors: Sawahata M, Sigiyama Y, Yamasawa H, Miki A, Yamamoto H, Muto S, Yamamoto H, Bando M Abstract nd in immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA). Paradoxically, this treatment induces sarcoidosis in a small population of RA patients as a class effect. A safer anti-TNF therapeutic strategy requires understanding of the risk factors for sarcoidosis. In Japan, TNF inhibitor was introduced in 2003. We reviewed 226 consecutive patients (65 men and 161 women) who were newly diagnosed with sarcoidosis between 2003 and 2012 at Jichi Medical University Hospital, Japan. We detected 3 cases...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Cardiac sarcoidosis - silent destroyer.
We report a case of histologically proven pulmonary sarcoidosis and cardiac involvement in a 53-year old woman with progression leading to the heart failure documented in cardiovascular magnetic resonsnce studies. PMID: 27537722 [PubMed - as supplied by publisher] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Pulmonary metastases from low grade sarcoma in a patient with pulmonary sarcoidosis. Sarcoidosis or sarcoid-like reaction?
Authors: Majori M, Anghinolfi M, Gnetti L, Casalini AG Abstract An asymptomatic man with previous histopatological diagnosis of pulmonary sarcoidosis in radiological follow-up (stable for about 4 years) presented massive right pleural effusion. After drainage, CT of the chest showed an increase in number and size of pulmonary nodules compared to the last check (8 months before). Surgical pulmonary biopsies were performed with the diagnosis of metastases from low grade sarcoma. The primary tumor was localized to the right buttock. Given the absence of symptoms, the extent of disease and many comorbidities the patien...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Polishing surgical metal pieces, granulomatosis and mineralogical analysis.
This study suggests that mineralogical analysis combined with a questionnaire on dust exposure could help redirect the diagnosis of a dust-related disease. PMID: 27537720 [PubMed - as supplied by publisher] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Exercise related ventilation dynamics and clinical correlates in patients with fibrotic idiopathic interstitial pneumonias.
Authors: De Martino M, Cobuccio R, Bruzzese D, Rea G, Meoli I, Stefanelli F, Canora A, Capaccio A, Sanduzzi A, Matarese A, Bocchino M Abstract Assessment of exercise performance is a key component in the management of interstitial lung diseases, as its limitation may occur very early. Aim of the present study was to assess ventilation dynamics in combination with pulse-oximetry changes in 54 clinically stable patients affected by idiopathic pulmonary fibrosis or idiopathic fibrotic nonspecific interstitial pneumonia. Testing was successfully performed with the Spiropalm 6-MWT Hand-held spirometer by the majority of...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Evaluation of Tpeak-Tend interval and Tpeak-end/QT ratio in patients with Sarcoidosis.
CONCLUSIONS: The novel repolarization parameters Tp-e interval, Tp-e/QT and Tp-e/QTc ratios are increased in patients with sarcoidosis without any cardiac symptoms. These parameters might be used as a marker for predicting the ventricular arrhythmias and sudden cardiac death in patients with sarcoidosis. PMID: 27537718 [PubMed - as supplied by publisher] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Platelet aggregability in patients with interstitial pneumonias.
CONCLUSIONS: Serum coagulation and fibrinolysis markers significantly increased in IIPs and CTD-IPs. In contrast, platelet aggregability was only weakly enhanced in CTDs, but not in IIPs. PMID: 27537717 [PubMed - as supplied by publisher] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research