Respiratory Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.
Pathophysiologic evaluation of the transgenic cftr "gut-corrected" porcine model of cystic fibrosis.
This study evaluated the pulmonary pathophysiology of the transgenic CFTR "gut-corrected" cystic fibrosis (CF) pigs. Four sows produced 18 piglets of which 11 were stillborn with only 2 animals surviving beyond 2 weeks. Failure to survive beyond the neonatal period by 5 piglets was judged to result from metabolic dysfunction related to genetic manipulation for CFTR gut expression or due to cloning artifact. Plasma analysis showed very low plasma proteins, highly elevated liver enzymes, and severe acidosis. All surviving offspring received furosemide for systemic edema. Physiologic evaluation was performed with lung tissues...
Source: Am J Physiol Lung Ce... - August 19, 2016 Category: Respiratory Medicine Authors: Ballard ST, Evans JW, Drag HS, Schuler M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Abstract We previously showed that newborn piglets who develop pulmonary hypertension during exposure to chronic hypoxia have diminished pulmonary vascular NO production and evidence of eNOS uncoupling. Tetrahydrobiopterin (BH4) is a co-factor that promotes eNOS coupling. Current clinical strategies typically invoke initiating treatment after the diagnosis of pulmonary hypertension, rather than prophylactically. The major purpose of this study was to determine whether starting treatment with an oral BH4 compound, Sapropterin Dihydrochloride (Sapropterin), after the onset of pulmonary hypertension would re-couple e...
Source: Am J Physiol Lung Ce... - August 19, 2016 Category: Respiratory Medicine Authors: Dikalova AE, Aschner JL, Kaplowitz MR, Summar M, Fike CD Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
2-aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive newborn lambs with partial gestation at high altitude.
2-AMINOETHYLDIPHENYLBORINATE MODIFIES THE PULMONARY CIRCULATION IN PULMONARY HYPERTENSIVE NEWBORN LAMBS WITH PARTIAL GESTATION AT HIGH ALTITUDE. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 19;:ajplung.00230.2016 Authors: Castillo-Galán S, Quezada S, Moraga FA, Ebensperger G, Herrera EA, Beñaldo F, Hernandez I, Ebensperger R, Ramirez S, Llanos AJ, Reyes RV Abstract Calcium signaling through store operated channels (SOC) is involved in hypoxic pulmonary hypertension. We determined whether a treatment with 2-aminoethyldiphenylborinate (2-APB), a compound with SOC blocker activity, reduces pulmonary hy...
Source: Am J Physiol Lung Ce... - August 19, 2016 Category: Respiratory Medicine Authors: Castillo-Galán S, Quezada S, Moraga FA, Ebensperger G, Herrera EA, Beñaldo F, Hernandez I, Ebensperger R, Ramirez S, Llanos AJ, Reyes RV Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
Interstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficient mice.
Abstract Angiopoietin-like protein 2 (ANGPTL2) is a chronic inflammatory mediator, which when deregulated is associated with various pathologies. However, little is known about its activity in lung. To assess a possible lung function, we generated a rabbit monoclonal antibody that specifically recognizes mouse ANGPTL2 and then evaluated protein expression in mouse lung tissue. We observed abundant ANGPTL2 expression in both alveolar epithelial type I and type II cells and in resident alveolar macrophages under normal conditions. To assess ANGPTL2 function, we compared lung phenotypes in Angptl2 knockout (KO) and w...
Source: Am J Physiol Lung Ce... - August 19, 2016 Category: Respiratory Medicine Authors: Motokawa I, Endo M, Terada K, Horiguchi H, Miyata K, Kadomatsu T, Morinaga J, Sugizaki T, Ito T, Araki K, Morioka MS, Manabe I, Samukawa T, Watanabe M, Inoue H, Oike Y Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
A Protonated Water Cluster as a Transient Proton-Loading Site in Cytochrome c Oxidase.
A Protonated Water Cluster as a Transient Proton-Loading Site in Cytochrome c Oxidase. Angew Chem Int Ed Engl. 2016 Aug 19; Authors: Supekar S, Gamiz-Hernandez AP, Kaila VR Abstract Cytochrome c oxidase (CcO) is a redox-driven proton pump that powers aerobic respiratory chains. We show here by multi-scale molecular simulations that a protonated water cluster near the active site is likely to serve as the transient proton-loading site (PLS) that stores a proton during the pumping process. The pKa of this water cluster is sensitive to the redox states of the enzyme, showing distinct similarities to ...
Source: Angewandte Chemie - August 19, 2016 Category: Chemistry Authors: Supekar S, Gamiz-Hernandez AP, Kaila VR Tags: Angew Chem Int Ed Engl Source Type: research
Allofrancisella inopinata gen. nov., sp. nov. and Allofrancisella frigidaquae sp. nov., isolated from water-cooling systems and transfer of Francisella guangzhouensis Qu et al. 2013 to the new genus as Allofrancisella guangzhouensis comb. nov.
Abstract Five bacterial strains isolated from water reservoirs of cooling systems were characterized using polyphasic taxonomic approaches. The isolates were observed to be Gram-negative, strictly aerobic and non-motile. Growth was enhanced in the presence of L-cysteine. The major fatty acids (>5 %) for strains were C10:0, C16:0, C16:0 3-OH, C18:0 3-OH and C18:1 9c. Ubiquinone-8 was detected as the respiratory quinone while the polar lipid profile consisted of phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol, phosphatidylcholine, three unidentified phospholipids, two unidentified aminophos...
Source: International Journal of Systematic and Evolutionary Microbiology - August 19, 2016 Category: Microbiology Authors: Qu PH, Li Y, Salam N, Chen SY, Liu L, Gu Q, Fang BZ, Xiao M, Li M, Chen C, Li WJ Tags: Int J Syst Evol Microbiol Source Type: research
Characterization and Evaluation of Newly Developed Immune-Chromatographic Method Targeting Mycoplasma pneumoniae Ribosomal Protein L7/L12.
Abstract Point-of-care testing (POCT) for Mycoplasma pneumoniae infection may be ideal and useful, because significant numbers of the cases will be seen as an outpatient. Recently, a new immune-chromatographic method (ICM) targeting M. pneumoniae ribosomal protein L7/L12 (RP-L7/L12) became available in Japan, although clinical data and basic information regarding efficacy and characterization of this ICM are limited. The present study examined the fate of M. pneumoniae ribosomal protein L7/L12 (RP-L7/L12) during the growth in-vitro and correlation between M. pneumoniae number in clinical samples and positivity in ...
Source: Journal of Medical Microbiology - August 19, 2016 Category: Microbiology Authors: Sano G, Itagaki T, Ishiwada N, Matsubara K, Iwata S, Nakamori Y, Matsuyama K, Watanabe K, Ishii Y, Homma S, Tateda K Tags: J Med Microbiol Source Type: research
Aging: a portrait from gene expression profile in blood cells.
We report here a microarray analysis of whole blood samples from two cohorts of healthy adult and elderly subjects, aged 43±3 and 68±4 years, respectively, to monitor gene expression changes in the initial phase of the senescence process. A number of significant changes were found in the elderly compared to the adult group, including decreased levels of transcripts coding for components of the mitochondrial respiratory chain, which correlate with a parallel decline in the maximum rate of oxygen consumption (VO2max), as monitored in the same subjects. In addition, blood cells show age-related changes in the expression of ...
Source: Aging - August 19, 2016 Category: Biomedical Science Authors: Calabria E, Mazza EM, Dyar KA, Pogliaghi S, Bruseghini P, Morandi C, Salvagno GL, Gelati M, Guidi GC, Bicciato S, Schiaffino S, Schena F, Capelli C Tags: Aging (Albany NY) Source Type: research
H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.
Abstract Sleep apnea is a prevalent respiratory disease in which episodic cessation of breathing causes intermittent hypoxia. Patients with sleep apnea and rodents exposed to intermittent hypoxia exhibit hypertension. The carotid body senses changes in blood O2 concentrations, and an enhanced carotid body chemosensory reflex contributes to hypertension in sleep apnea patients. A rodent model of intermittent hypoxia that mimics blood O2 saturation profiles of patients with sleep apnea has shown that increased generation of reactive oxygen species (ROS) in the carotid body enhances the chemosensory reflex and trigge...
Source: Science Signaling - August 18, 2016 Category: Biomedical Science Authors: Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR Tags: Sci Signal Source Type: research
Equipoise is necessary for randomising patients to clinical trials
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - August 18, 2016 Category: Pediatrics Authors: Gorm Greisen, Frank Bel Tags: A Different View Source Type: research
Respiratory Viral Infections and Coinfections in Children With Cancer, Fever and Neutropenia: Clinical Outcome of Infections Caused by Different Respiratory Viruses
Conclusions: To our knowledge, this is the largest report comparing clinical outcome in FN episodes caused by different RVs in children with cancer. A positive polymerase chain reaction for RV at admission was significantly associated with the presence of respiratory symptoms. Our data showed a favorable outcome in all episodes with RV detection, including single and viral coinfections. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 18, 2016 Category: Infectious Diseases Tags: Original Studies Source Type: research
Ten-Year Study of the Stringently Defined Otitis-prone Child in Rochester, NY
This review summarizes a prospective, longitudinal 10-year study in Rochester, NY, with virtually every clinically diagnosed acute otitis media (AOM) confirmed by bacterial culture of middle ear fluid. Children experiencing 3 episodes within 6 months or 4 episodes in 12 months were considered stringently defined otitis prone (sOP). We found stringent diagnosis compared with clinical diagnosis reduced the frequency of children meeting the OP definition from 27% to 6% resulting in 14.8% and 2.4% receiving tympanostomy tubes, respectively. Significantly more often respiratory syncytial virus infection led to AOM in sOP than n...
Source: The Pediatric Infectious Disease Journal - August 18, 2016 Category: Infectious Diseases Tags: Review Articles Source Type: research
Inflammatory and oxidative stress airway markers in premature newborns of hypertensive mothers.
In conclusion, the biomarkers evaluated were not increased in premature infants of hypertensive mothers and were not predictors of BPD/death. PMID: 27533763 [PubMed - as supplied by publisher] (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - August 18, 2016 Category: Research Authors: Madoglio RJ, Rugolo LM, Kurokawa CS, Sá MP, Lyra JC, Antunes LC Tags: Braz J Med Biol Res Source Type: research
Ontogeny and microanatomy of the nasal turbinals in lemuriformes
This article is protected by copyright. All rights reserved. (Source: The Anatomical Record Part B: The New Anatomist)
Source: The Anatomical Record Part B: The New Anatomist - August 18, 2016 Category: Anatomy Authors: Timothy D. Smith, Molly C. Martell, James B. Rossie, Christopher J. Bonar, Valerie B. DeLeon Tags: Full Length Article Source Type: research
Speckle tracking as a method to measure hemidiaphragm excursion
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - August 18, 2016 Category: Internal Medicine Authors: Stephen A. Goutman, James D. Hamilton, Blake Swihart, Bradley Foerster, Eva L. Feldman, Jonathan M. Rubin Tags: Short Reports Source Type: research
Efficacy of a new technique – INtubate-RECruit-SURfactant-Extubate – “IN-REC-SUR-E” – in preterm neonates with respiratory distress syndrome: study protocol for a randomized controlled trial
Although beneficial in clinical practice, the INtubate-SURfactant-Extubate (IN-SUR-E) method is not successful in all preterm neonates with respiratory distress syndrome, with a reported failure rate ranging f... (Source: Trials)
Source: Trials - August 18, 2016 Category: Journals (General) Authors: Giovanni Vento, Roberta Pastorino, Luca Boni, Francesco Cota, Virgilio Carnielli, Filip Cools, Carlo Dani, Fabio Mosca, Jane Pillow, Graeme Polglase, Paolo Tagliabue, Anton H. van Kaam, Maria Luisa Ventura, Milena Tana, Chiara Tirone, Claudia Aurilia & he Source Type: research
Aspergillus nodules; another presentation of Chronic Pulmonary Aspergillosis
This study aims to review the radiology, presentation, and histological features of lung nodules caused by Aspergillus spp. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 18, 2016 Category: Respiratory Medicine Authors: Eavan G. Muldoon, Anna Sharman, Iain Page, Paul Bishop and David W. Denning Source Type: research
Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers
We aimed to investigate the immediate respiratory effects of cigar smoking(CS), among young smokers with and without mild asthma. (Source: Tobacco Induced Diseases)
Source: Tobacco Induced Diseases - August 18, 2016 Category: Global & Universal Authors: Andreas S. Lappas, Efstathia M. Konstantinidi, Anna S. Tzortzi, Chara K. Tzavara and Panagiotis K. Behrakis Source Type: research
Agent kills pain like morphine but loses some side effects
Researchers find molecule that turns on opioid pain-relief pathway but skips one associated with constipation and respiratory distress (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - August 18, 2016 Category: Chemistry Authors: Stu Borman Source Type: research
Smoking and New-Onset Asthma in a Prospective Study on Italian Adults
Conclusions: In this prospective study, current smoking was not a risk factor for new-onset asthma, unless new-onset wheezing was also considered. The increase in asthma incidence among ex-smokers was likely due to reverse causation.Int Arch Allergy Immunol 2016;170:149-157 (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - August 18, 2016 Category: Allergy & Immunology Source Type: research
Heart Rate and Respiratory Rate Influence on Heart Rate Variability Repeatability: Effects of the Correction for the Prevailing Heart Rate
Jakub S. G ąsior, Jerzy Sacha, Piotr J. Jeleń, Jakub Zieliński, Jacek Przybylski (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - August 18, 2016 Category: Physiology Source Type: research
Identifying pre-hospital factors which influence outcome for major trauma patients in a regional trauma network: an exploratory study
Conclusion These findings validate GCS, BP and Respiratory Rate values as valid triggers for transport to a Major Trauma Centre. Analysis of the interactions between arrival time, time-on-scene, skill mix and age demand further exploration but tentatively validate the concept of a ‘Golden Hour’ and suggest the potential value of a ‘load and go and play on the way’ approach. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - August 18, 2016 Category: Emergency Medicine Authors: Thompson, L., Hill, M., Davies, C., Shaw, G. Tags: Poster Presentations Source Type: research
Point-of-care lung ultrasound in young children with respiratory tract infections and wheeze
Conclusions Among children with respiratory tract infections and wheeze, a positive LUS seems to distinguish between clinical syndromes by ruling in pneumonia and ruling out asthma. If confirmed in future studies, LUS may emerge as a point-of-care tool to guide diagnosis and disposition in young children with wheeze. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - August 18, 2016 Category: Emergency Medicine Authors: Varshney, T., Mok, E., Shapiro, A. J., Li, P., Dubrovsky, A. S. Tags: Bronchiolitis, Pneumonia (infectious disease), TB and other respiratory infections, Child health, Radiology, Asthma, Bronchitis, Pneumonia (respiratory medicine), Clinical diagnostic tests, Radiology (diagnostics) Original article Source Type: research
Uncoupling Protein 2 Deficiency Results in Higher Neutrophil Counts and Lower B Cell Counts During Ageing in Mice
Progress of age-related haematopoietic diseases as myelodysplastic syndrome has previously been linked to enhanced levels of reactive oxygen species (ROS). Uncoupling protein 2 (UCP2) was shown to reduce mitochondrial ROS production by uncoupling of the respiratory chain. The impact of UCP2 loss and elevated ROS on haematopoiesis during ageing has not yet been investigated. Herein, UCP2 knockout mice were analyzed at ageing stages of 3, 12 and 24 months in regard to oxidative and energy status of bone marrow cells. (Source: Experimental Hematology)
Source: Experimental Hematology - August 18, 2016 Category: Hematology Authors: Christin Kretzschmar, Catrin Roolf, Katrin Timmer, Anett Sekora, Gudrun Kn übel, Hugo Murua Escobar, Robert Jaster, Sarah Müller, Georg Fuellen, Rüdiger Köhling, Christian Junghanss Source Type: research
Down's syndrome as a risk factor for severe lower respiratory tract infection due to RSV
ConclusionChildren with Down's syndrome hospitalized due to RSV LRTI, have a longer hospital stay and worse clinical course than children without. Our findings support the need of RSV prevention in children with Down's syndrome, especially in children younger than one year.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - August 18, 2016 Category: Pediatrics Authors: Constanza Galleguillos, B árbara Galleguillos, Guillermo Larios, Gonzalo Menchaca, Louis Bont, Jose A. Castro‐Rodriguez Tags: Regular Article Source Type: research
Implementation of ‘matrix support’ (collaborative care) to reduce asthma and COPD referrals and improve primary care management in Brazil: a pilot observational study
npj Primary Care Respiratory Medicine, Published online: 18 August 2016; doi:10.1038/npjpcrm.2016.47 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - August 18, 2016 Category: Primary Care Authors: Sonia Maria Martins William Salibe-Filho Lu ís Paulo Tonioli Lu ís Eduardo Pfingesten Patr ícia Dias Braz Juliet McDonnell Si ân Williams D ébora do Carmo Jaime Correia de Sousa Hilary Pinnock Rafael Stelmach Source Type: research
Asthma prescribing, ethnicity and risk of hospital admission: an analysis of 35,864 linked primary and secondary care records in East London
npj Primary Care Respiratory Medicine, Published online: 18 August 2016; doi:10.1038/npjpcrm.2016.49 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - August 18, 2016 Category: Primary Care Authors: Sally A Hull Shauna McKibben Kate Homer Stephanie JC Taylor Katy Pike Chris Griffiths Source Type: research
Characterization of bronchiectasis in the elderly
This study aimed at evaluating bronchiectasis features in older adults and elderly, along with their clinical outcomes. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 18, 2016 Category: Respiratory Medicine Authors: Giuseppe Bellelli, James D. Chalmers, Giovanni Sotgiu, Simone Dore, Melissa J. McDonnell, Pieter C. Goeminne, Katerina Dimakou, Dusan Skrbic, Andrea Lombi, Federico Pane, Dusanka Obradovic, Thomas C. Fardon, Robert M. Rutherford, Alberto Pesci, Stefano Al Source Type: research
Effects of < i > Porphyromonas gingivalis < /i > LipopolysaccharideTolerized Monocytes on Inflammatory Responses in Neutrophils
by Xiang-qing Zhu, Wei Lu, Yang Chen, Xiao-fan Cheng, Jia-ying Qiu, Yan Xu, Ying Sun Periodontitis is a chronic inflammatory disease induced by bacteria. Exposure of the host to periodontal pathogens and their virulence factors induces a state of hyporesponsiveness to subsequent stimulations, which is termed endotoxin tolerance. The role and mechanism of lipopolysaccharide (LPS)– tolerized monocytes in inflammatory responses in neutrophils are currently unclear. Here, conditioned supernatants were collected from THP-1 cells treated with or without repeated 1 μg/mlPorphyromonas gingivalis (P.gingivalis) LPS. The chemota...
Source: PLoS One - August 18, 2016 Category: Biomedical Science Authors: Xiang-qing Zhu Source Type: research
A randomised trial of placing preterm infants on their back or left side after birth
Conclusions Preterm infants on their left side did not have higher SpO2 at 5 min of life. Placing preterm infants on their side at birth is feasible and appears to be a reasonable alternative to placing them on their back. Trial registration number ISRCTN74486341. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2016 Category: Perinatology & Neonatology Authors: Stenke, E., Kieran, E. A., McCarthy, L. K., Dawson, J. A., Van Vonderen, J. J., Kamlin, C. O. F., Davis, P. G., Te Pas, A. B., O'Donnell, C. P. F. Tags: Airway biology Original articles Source Type: research
High-flow support in very preterm infants in Australia and New Zealand
Conclusions HF use in extremely preterm and very preterm infants increased significantly within the ANZNN from 2009 to 2012. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2016 Category: Perinatology & Neonatology Authors: Roberts, C. T., Owen, L. S., Manley, B. J., Davis, P. G., for the Australian & New Zealand Neonatal Network (ANZNN) Tags: Epidemiologic studies, Child health, Infant health, Neonatal and paediatric intensive care, Neonatal health, Neonatal intensive care Original articles Source Type: research
High-flow nasal cannula oxygen and nasal continuous positive airway pressure and full oral feeding in infants with bronchopulmonary dysplasia
Conclusions In infants with BPD who required respiratory support beyond 34 weeks PMA, use of nCPAP then HHFNC was associated with earlier establishment of full oral feeds. Consideration should be given to assessing stable BPD infants with regard to oral feeding while on CPAP. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2016 Category: Perinatology & Neonatology Authors: Shetty, S., Hunt, K., Douthwaite, A., Athanasiou, M., Hickey, A., Greenough, A. Tags: Bronchopulmonary dysplasia, Clinical trials (epidemiology) Original articles Source Type: research
Prediction of infant extubation outcomes using the tension-time index
Conclusions Assessment of TTdi and TTmus cannot be recommended for use in routine clinical practice. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2016 Category: Perinatology & Neonatology Authors: Bhat, P., Peacock, J. L., Rafferty, G. F., Hannam, S., Greenough, A. Tags: Airway biology Original articles Source Type: research
Systemic endogenous erythropoietin and associated disorders in extremely preterm newborns
Conclusions EPO blood concentrations in extremely preterm newborns during the first 2 weeks of life convey information about increased risks of bowel, lung and retinal diseases. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2016 Category: Perinatology & Neonatology Authors: Holm, M., Skranes, J., Dammann, O., Fichorova, R. N., Allred, E. N., Leviton, A. Tags: Eye Diseases, Bronchopulmonary dysplasia, Epidemiologic studies, Ophthalmology, Drugs: endocrine system Original articles Source Type: research
Therapeutic hypothermia in neonatal cervical spine injury
A baby boy (39 weeks; 3350 g) delivered by forceps following shoulder dystocia was born in a poor condition requiring invasive respiratory support (Apgar scores at 1, 5 and 10 min were 3, 4 and 5, respectively). He was started on passive cooling at the local neonatal unit, and then referred to our centre. At admission, the baby had flaccid quadriparesis, absent deep tendon reflexes and lacked spontaneous respiration; however, the baby had a weak suck and opened his eyes spontaneously. Amplitude-integrated electroencephalography was normal. An MR scan at 12 h showed severe haemorrhagic contusion of the c...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2016 Category: Perinatology & Neonatology Authors: Montaldo, P., Oliveira, V., Lally, P. J., Chaban, B., Atreja, G., Kirmi, O., Thayyil, S. Tags: Obstetrics and gynaecology, Journalology, Neurological injury, Pregnancy, Child health, Disability, Competing interests (ethics), Trauma, Injury Images in neonatal medicine Source Type: research
Hypofractionated ablative radiotherapy for locally advanced pancreatic cancer
The role of radiation in locally advanced unresectable pancreatic cancer (LAPC) is controversial. Randomized trials evaluating standard doses of chemoradiation have not shown a significant benefit from the use of consolidative radiation. Results from non-randomized studies of 3–5-fraction stereotactic body radiotherapy (SBRT) have been similar to standard chemoradiation, but with less toxicity and a shorter treatment time. Doses of SBRT have been reduced to subablative levels for the sake of tolerability. The benefit of both options is unclear. In contrast, ablative doses can be delivered using an SBRT technique in 1...
Source: Journal of Radiation Research - August 18, 2016 Category: Physics Authors: Crane, C. H. Tags: Supplement - ICRR highlights Source Type: research
GPU accelerated dynamic respiratory motion model correction for MRI-guided cardiac interventions
• The highlight of this study is that a GPU accelerated dynamic motion model framework is described.• The proposed method is able to correct for respiratory motion in realtime, and be adaptive to changes in breathing pattern.• This methodology can be used to improve the accuracy of MRI guided cardiovascular interventions. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - August 18, 2016 Category: Bioinformatics Authors: Robert Xu, Graham A. Wright Source Type: research
Duox2 is required for the transcription of pattern recognition receptors in acute viral lung infection: An interferon-independent regulatory mechanism
Publication date: Available online 18 August 2016 Source:Antiviral Research Author(s): Seung-No Hong, Ji Young Kim, Hanna Kim, Dong-Young Kim, Tae-Bin Won, Doo Hee Han, Chae Seo Rhee, Hyun Jik Kim The innate immune response, which constitutes the first line of defense against influenza A virus (IAV) infection, is activated by pattern recognition receptors (PRRs) that recognize viral structures. We found that the PRRs, retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), which have been implicated as interferon (IFN)-stimulated genes, were dominantly responsible for the recogniti...
Source: Antiviral Therapy - August 18, 2016 Category: Virology Source Type: research
Functional Food and dietary supplements For Lung Health
Conclusions This plant metabolites benefits lung health by anti-inflammatory, immune-modulatory, and antioxidant effects. Many pungent flavor components in edible plants activate the mucous membranes of the respiratory tract to help fight microbes and remove undesirable agents. These flavor and aroma compounds can behave as expectorants, decongestant, antitussive, and antimicrobial agents. They enhance mucous membrane secretion, kill pathogens, reduce inflammation and decrease mucous viscosity by weakening the hydrogen bonds in the mucous. For lung cancer, certain plant metabolites help induce apoptosis, suppress angiogene...
Source: Trends in Food Science and Technology - August 18, 2016 Category: Food Science Source Type: research
Scoring of pediatric polysomnograms
This article highlights the problems associated with recording and scoring pediatric polysomnograms according to AASM rules with respect to the number of necessary electrodes, study over one or two nights, scoring of sleep stages (specific patterns for scoring sleep stages and the delta wave amplitude criterion), arousal definition, scoring movements and movement times, and scoring the respiratory pattern. Individual examples are discussed in each case. Beyond the fundamental aspects laid down in the AASM rules, recording and scoring polysomnograms in children necessitates additional understanding of development-specific c...
Source: Somnologie - Schlafforschung und Schlafmedizin - August 18, 2016 Category: Sleep Medicine Source Type: research
Applicability of data-driven respiratory motion correction to CZT SPECT myocardial perfusion imaging in the clinical setting: The birth of an old wish
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 18, 2016 Category: Nuclear Medicine Source Type: research
The P4 Health Spectrum – A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan
Chronic diseases (i.e., Noncommunicable Diseases), mainly cardiovascular disease, cancer, respiratory diseases and type-2-diabetes, are now the leading cause of death, disability and diminished quality of life on the planet. Moreover, these diseases are also a major financial burden worldwide, significantly impacting the economy of many countries. Healthcare systems and medicine have progressively improved upon the ability to address infectious diseases and react to adverse health events through both surgical interventions and pharmacology; we have become efficient in delivering reactive care (i.e., initiating intervention...
Source: Progress in Cardiovascular Diseases - August 18, 2016 Category: Cardiology Authors: Michael Sagner, Amy McNeil, Pekka Puska, Charles Auffray, Nathan D. Price, Leroy Hood, Carl J. Lavie, Ze-Guang Han, Zhu Chen, Samir Kumar Brahmachari, Bruce S. McEwen, Marcelo B. Soares, Rudi Balling, Elissa Epel, Ross Arena Source Type: research
Optimizing Oxygenation in the Mechanically Ventilated Patient
This article discusses fundamental aspects of respiratory physiology and clinical indices used to describe oxygenation status. Key nursing interventions including patient assessment, positioning, pharmacology, and managing hemodynamic parameters are discussed, emphasizing their effects toward mitigating ventilation –perfusion mismatch and optimizing oxygenation. (Source: Critical Care Nursing Clinics of North America)
Source: Critical Care Nursing Clinics of North America - August 18, 2016 Category: Nursing Authors: Glenn Barton, Brandi Vanderspank-Wright, Jacqueline Shea Source Type: research
Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region
Pathogenic bacteria such as Haemophilus influenzae, a major cause of lower respiratory tract diseases, must cope with a range of electrophiles generated in the host or by endogenous metabolism. Formaldehyde is one such compound that can irreversibly damage proteins and DNA through alkylation and cross-linking and interfere with redox homeostasis. Its detoxification operates under the control of HiNmlR, a protein from the MerR family that lacks a specific sensor region and does not bind metal ions. We demonstrate that HiNmlR is a thiol-dependent transcription factor that modulates H. influenzae response to formaldehyde, wit...
Source: Nucleic Acids Research - August 18, 2016 Category: Research Authors: Counago, R. M., Chen, N. H., Chang, C.-W., Djoko, K. Y., McEwan, A. G., Kobe, B. Tags: Structural Biology Source Type: research
Air pollution during pregnancy and lung development in the child
Air pollution exposure has increased extensively in recent years and there is considerable evidence that exposure to particulate matter can lead to adverse respiratory outcomes. The health impacts of exposure to air pollution during the prenatal period is especially concerning as it can impair organogenesis and organ development, which can lead to long-term complications. Exposure to air pollution during pregnancy affects respiratory health in different ways. Lung development might be impaired by air pollution indirectly by causing lower birth weight, premature birth or disturbed development of the immune system. (Source: ...
Source: Paediatric Respiratory Reviews - August 18, 2016 Category: Respiratory Medicine Authors: Insa Korten, Kathryn Ramsey, Philipp Latzin Source Type: research
Diabetes in pregnancy and lung health in offspring: developmental origins of respiratory disease
Diabetes is an increasingly common complication of pregnancy. In parallel with this trend, a rise in chronic lung disease in children has been observed in recent decades. While several adverse health outcomes associated with exposure to diabetes in utero have been documented in epidemiological and experimental studies, few have examined the impact of diabetes in pregnancy on offspring lung health and respiratory disease. We provide a comprehensive overview of current literature on this topic, finding suggestive evidence that exposure to diabetes in utero may have adverse effects on lung development. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - August 18, 2016 Category: Respiratory Medicine Authors: Azad MB, Moyce BL, Guillemette L, Pascoe CD, Wicklow B, McGavock JM, Halayko AJ, Dolinsky VW Source Type: research