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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

RSV-specific anti-viral immunity is disrupted by chronic ethanol consumption
Alcohol-use disorders (AUD) persist in the United States and are heavily associated with an increased susceptibility to respiratory viral infections. Respiratory syncytial virus (RSV) in particular has received attention as a viral pathogen commonly detected in children and immune-compromised populations (elderly, asthmatics), yet more recently was recognized as an important viral pathogen in young adults. Our study evaluated the exacerbation of RSV-associated illness in mice that chronically consumed alcohol for 6 weeks prior to infection. (Source: Alcohol)
Source: Alcohol - August 24, 2016 Category: Addiction Authors: Kristi J. Warren, Samantha M. Simet, Jacqueline A. Pavlik, Jane M. DeVasure, Joseph H. Sisson, Jill A. Poole, Todd A. Wyatt Source Type: research

Investigating asthma comorbidities: a systematic scoping review protocol
Introduction Asthma is a common long-term disorder with a number of related comorbid conditions, which may affect asthma outcomes. There is a need for greater appreciation for understanding how these comorbidities interact with asthma in order to improve asthma outcomes. Objectives To systematically identify and map out key asthma comorbidities. Methods We will systematically search the following electronic databases: MEDLINE, EMBASE, ISI Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO and Google Scholar. Additional literature will be identified by searching the reference list ...
Source: BMJ Open - August 24, 2016 Category: Journals (General) Authors: El Ferkh, K., Nwaru, B., Griffiths, C., Sheikh, A. Tags: Open access, Epidemiology, Immunology (including allergy), Respiratory medicine Protocol Source Type: research

Intrauterine growth restriction impairs right ventricular response to hypoxia in adult male rats.
CONCLUSIONS: In adult IUGR-born rats, mitochondria from RV are hypersensitive to oxygen deprivation and this translates into maladaptive RV cardiac response to acute hypoxia.Pediatric Research (2016); doi:10.1038/pr.2016.124. PMID: 27557421 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - August 24, 2016 Category: Pediatrics Authors: Keenaghan M, Sun L, Wang A, Hyodo E, Homma S, Ten VS Tags: Pediatr Res Source Type: research

New Guidelines for the Treatment of Drug-susceptible Tuberculosis from the American Thoracic Society, Centers for Disease Control and the Infectious Disease Society of America: Now Comes the Hard Part.
PMID: 27556737 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 24, 2016 Category: Respiratory Medicine Authors: Metersky ML, Schluger NW Tags: Am J Respir Crit Care Med Source Type: research

Wandering Pleural Mesothelial Fatty Cyst.
PMID: 27556583 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 24, 2016 Category: Respiratory Medicine Authors: Nicholson TT, Raparia K, Mutlu GM, Sporn PH, Bharat A Tags: Am J Respir Crit Care Med Source Type: research

Acute Exacerbations and Lung Function Loss in Smokers With and Without COPD.
Conclusions Exacerbations are associated with accelerated lung function loss in subjects with established COPD, particularly those with mild disease. Clinical trial registration available at www.clinicaltrials.gov, ID NCT00608764. PMID: 27556408 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 24, 2016 Category: Respiratory Medicine Authors: Dransfield MT, Kunisaki KM, Strand MJ, Anzueto A, Bhatt SP, Bowler RP, Criner GJ, Curtis JL, Hanania NA, Nath H, Putcha N, Roark SE, Wan ES, Washko GR, Wells JM, Wendt CH, Make BJ, COPDGene Investigators Tags: Am J Respir Crit Care Med Source Type: research

Systems Biology and Clinical Practice in Respiratory Medicine: The Twain Shall Meet.
We describe new studies using temporal complexity patterns to characterize asthma and COPD and predict exacerbations, as well as predict adverse outcomes in critical care. We highlight new methods which are emerging with this approach, and discuss remaining questions which merit greater attention in the field. PMID: 27556336 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 24, 2016 Category: Respiratory Medicine Authors: Thamrin C, Frey U, Kaminsky DA, Reddel HK, Seely AJ, Suki B, Sterk PJ Tags: Am J Respir Crit Care Med Source Type: research

Inflammatory and Co-Morbid Features of Patients with Severe Asthma and Frequent Exacerbations.
CONCLUSIONS: EPA may be a distinct susceptibility phenotype with implications for the targeting of exacerbation prevention strategies. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01760915. PMID: 27556234 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 24, 2016 Category: Respiratory Medicine Authors: Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Tags: Am J Respir Crit Care Med Source Type: research

RTP801 Amplifies Nox-4-dependent Oxidative Stress Induced by Cigarette Smoke.
Abstract Tobacco smoke (TS) causes chronic obstructive pulmonary disease including, chronic bronchitis, emphysema and asthma. Rtp801, an inhibitor of mTORC1, is induced by oxidative stress triggered by TS. Its upregulation drives lung susceptibility to TS injury by means of enhancing inflammation and alveolar destruction. We postulated that Rtp801 is not only increased by reactive oxygen species (ROS) in TS, but it is instrumental in creating a feedforward process leading to amplification of endogenous ROS generation. We used cigarette smoke extract (CSE) to model the effect of TS in wild type (Wt) and knockout (K...
Source: Am J Respir Cell Mol... - August 24, 2016 Category: Respiratory Medicine Authors: Hernández-Saavedra D, Sanders L, Perez MJ, Kosmider B, Smith LP, Mitchell JD, Yoshida T, Tuder RM Tags: Am J Respir Cell Mol Biol Source Type: research

An Inhaled Inhibitor of MARCKS Reverses LPS-induced Acute Lung Injury in Mice.
Abstract Intratracheal (IT) instillation of bacterial lipopolysaccharide (LPS) is a well-established model of acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). Since the myristoylated alanine-rich C Kinase substrate (MARCKS) protein is involved in neutrophil migration and proinflammatory cytokine production, we examined whether an aerosolized peptide that inhibits MARCKS function could attenuate LPS - induced lung injury in mice. The peptide, BIO-11006, was delivered at 50 μM via inhalation either just prior to IT instillation of 5μg of LPS into Balb/C mice, or 4, 12, 24 or 36 hrs after ...
Source: Am J Respir Cell Mol... - August 24, 2016 Category: Respiratory Medicine Authors: Yin Q, Fang S, Park J, Crews AL, Parikh I, Adler KB Tags: Am J Respir Cell Mol Biol Source Type: research

A brief clinical case of monitoring of oxygenator performance and patient-machine interdependency during prolonged veno-venous extracorporeal membrane oxygenation
AbstractMonitoring veno-venous extracorporeal membrane oxygenation (vvECMO) during 76  days of continuous support in a 42-years old patient with end-stage pulmonary disease, listed for double-lung transplantation. Applying a new monitor (Landing®, Eurosets, Medolla, Italy) and describing how measured and calculated parameters can be used to understand the variable interdependency between artificial membrane lung (ML) and patient native lung (NL). During vvECMO, in order to understand how the respiratory function is shared between ML and NL, ideally we should obtain data about oxygen transfer and CO2 removal, both by ML a...
Source: Journal of Clinical Monitoring and Computing - August 24, 2016 Category: Information Technology Source Type: research

Lung cancer among native and foreign-born Swedes: histopathology, treatment, and survival.
CONCLUSION: FBS patients were significantly younger than NatS at diagnosis, and female FBS lived longer than female NatS, but otherwise there were no significant differences between NatS and FBS patients with LC regarding diagnosis, treatment, and survival. PMID: 27556916 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 24, 2016 Category: Cancer & Oncology Authors: Koyi H, Hillerdal G, Andersson O, Högberg H, Brandén E Tags: Acta Oncol Source Type: research

From Genesis To Revelation: The Role Of Inflammatory Mediators In Chronic Respiratory Diseases And Their Control By Nucleic Acid-Based Drugs.
Abstract Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical role in their pathogenesis. Moreover, immune cells, particularly neutrophils, macrophages and dendritic cells as well structural cells such as epithelial and airway smooth muscle cells are also involved in the pathogenic cycle of these diseases. There is a pressing need for the development of ne...
Source: Current Drug Delivery - August 24, 2016 Category: Drugs & Pharmacology Authors: Di Gioia S, Sardo C, Castellani S, Porsio B, Belgiovine G, Carbone A, Giammona G, Cavallaro G Tags: Curr Drug Deliv Source Type: research

Impaired utilization of membrane potential by complex II-energized mitochondria of obese, diabetic mice assessed using ADP recycling methodology.
Abstract Recently, we used an ADP recycling approach to examine mouse skeletal muscle (SkM) mitochondrial function over respiratory states intermittent between state 3 and 4. We showed that respiration energized at complex II by succinate, in the presence of rotenone to block complex I, progressively increased with incremental additions of ADP. However, in the absence of rotenone, respiration peaked at low [ADP] but then dropped markedly as [ADP] was further increased. Here, we tested the hypothesis that these respiratory dynamics would differ between mitochondria of mice fed high-fat (HF) and treated with a low d...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 24, 2016 Category: Physiology Authors: Fink BD, Bai F, Yu L, Sivitz WI Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Pharmacokinetics and Tolerability of Obiltoxaximab: A Report of 5 Healthy Volunteer Studies.
This report describes the safety, immunogenicity, and pharmacokinetic results of obiltoxaximab treatment in healthy subjects from 5 clinical trials. METHODS: Healthy men and women were enrolled in randomized, double-blind studies of obiltoxaximab versus placebo (studies 1-3), an open-label, parallel-group study of obiltoxaximab alone versus obiltoxaximab and ciprofloxacin (study 4), or a randomized, double-blind, placebo-controlled study involving administration of a second dose of obiltoxaximab 13 or 119 days after an initial dose (study 5). Obiltoxaximab was administered intravenously in all studies. The safety prof...
Source: Clinical Therapeutics - August 24, 2016 Category: Drugs & Pharmacology Authors: Nagy CF, Leach TS, Hoffman JH, Czech A, Carpenter SE, Guttendorf R Tags: Clin Ther Source Type: research

Obesity is Associated with Increased Morbidity in Moderate to Severe COPD.
CONCLUSIONS: Obesity is prevalent among individuals with COPD and associated with worse COPD-related outcomes, ranging from QOL and dyspnea to 6MWD and severe AECOPD. These associations were strengthened when obesity was analyzed as a dose-dependent response. Obesity in patients with COPD may contribute to a worse COPD-related course. PMID: 27568229 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - August 24, 2016 Category: Respiratory Medicine Authors: Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, Kinney GL, McDonald MN, Brigham EP, Wise RA, McCormack C, Hansel NN, COPDGene Investigators Tags: Chest Source Type: research

Effects of Implementation of Lung Cancer Screening at One Veterans Affairs Medical Center.
CONCLUSIONS: Implementation of lung cancer screening in the veteran population leads to detection of increased number and proportion of early stage lung cancers. Lung cancer screening in veterans may also increase the rate of lung cancer diagnoses in the immediate post-implementation period. PMID: 27568228 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - August 24, 2016 Category: Respiratory Medicine Authors: Okereke IC, Bates MF, Jankowich MD, Rounds SI, Kimble BA, Baptiste JV, Ng TT, Nici LL Tags: Chest Source Type: research

The Pharmacology & Toxicology of the “Holy Trinity”
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 23, 2016 Category: Drugs & Pharmacology Authors: Joseph T. Horsfall, Jon E. Sprague Tags: Mini ‐Review Source Type: research

Nivolumab-Induced Pericardial Tamponade: A Case Report and Discussion
We present the case of a 67-year-old male patient with metastatic squamous cell carcinoma of the lung who suffered from a massive pericardial effusion secondary to treatment with nivolumab, which he began in June 2015. After five cycles the patient was hospitalized due to acute respiratory failure requiring mechanical ventilation. An echocardiogram revealed a massive pericardial effusion with tamponade. After pericardiocentesis and corticosteroid treatment, the patient's condition improved rapidly. A CT scan revealed a response of the tumor. Although anti-PD1 treatment is usually regarded as less toxic than chemotherapy, a...
Source: Cardiology - August 23, 2016 Category: Cardiology Source Type: research

The future of inhalers: how can we improve drug delivery in asthma and COPD?
Authors: Rogueda P, Traini D PMID: 27545190 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - August 23, 2016 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Anti-IgE therapy as novel target for asthma-COPD overlap syndrome: more questions before celebration.
Authors: Xia Y, Li W, Shen H PMID: 27547882 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - August 23, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Telehealthcare for Chronic Obstructive Pulmonary Disease in Switzerland Is Feasible and Appreciated by Patients
Conclusions: Adding THC to state-of-the-art COPD management is feasible in a selected subgroup of patients. We estimate that up to 50% of COPD patients could be eligible for a THC strategy. Patient compliance, acceptance and satisfaction were very high. With the proposed approach, we missed only very few AECOPD events. However, a telephone-based verification of THC alerts was required. Overall, in this proof-of-concept study, we experienced a positive effort-to-benefit ratio.Respiration (Source: Respiration)
Source: Respiration - August 23, 2016 Category: Respiratory Medicine Source Type: research

‘Idiopathic' Effusions Get a Proper Name
Respiration (Source: Respiration)
Source: Respiration - August 23, 2016 Category: Respiratory Medicine Source Type: research

The Importance of Obligate Anaerobes and the Streptococcus anginosus Group in Pulmonary Abscess: A Clone Library Analysis Using Bronchoalveolar Lavage Fluid
Conclusions: The findings by the molecular method suggest that obligate anaerobes play important roles in the pathogenesis of lung abscess and provide additional bacterial information regarding conventional culture methods.Respiration (Source: Respiration)
Source: Respiration - August 23, 2016 Category: Respiratory Medicine Source Type: research

Early Predictors of Mortality in Geriatric Patients With Trauma
Objective: To identify variables that predict mortality in geriatric patients with trauma. Design: Retrospective review. Setting: Level I trauma center. Patients/Participants: A total of 147 geriatric patients with trauma (age ≥65) with a predicted probability of survival of 10%–75% based on the Trauma Score-Injury Severity Score (TRISS). Main Outcome Measurements: Patients were divided into 2 cohorts: survivors and nonsurvivors. The following variables available at presentation were analyzed: age, mechanism of injury, temperature, systolic blood pressure, pulse rate, shock index, respiratory rate, Glasgow Coma Sca...
Source: Journal of Orthopaedic Trauma - August 23, 2016 Category: Orthopaedics Tags: Original Article Source Type: research

Infection in Early Life and Risk of Developing Type 1 Diabetes
In Reply Dr Rahmoune and colleagues and Mr Uzoigwe suggest that unmeasured confounding might have influenced the results of our study. The results are consistent with findings from a previous analysis that observed a strong association between respiratory infections during the first 6 months of life and development of beta cell autoimmunity in infants with a family history of T1D. This association was independent of early variables such as delivery mode, age at gluten introduction, season of birth, and antibiotic use in children, and could not be explained by modulations of the gut microbiome, suggesting that such confound...
Source: JAMA - August 23, 2016 Category: Journals (General) Source Type: research

Noninvasive ventilation with helmet versus control strategy in patients with acute respiratory failure: a systematic review and meta-analysis of controlled studies
Noninvasive ventilation (NIV) has proved to be a useful technique for breathing support. However, complications, discomfort, and failure of NIV were commonly caused by the mask. Therefore, the helmet was devel... (Source: Critical Care)
Source: Critical Care - August 23, 2016 Category: Intensive Care Authors: Qi Liu, Yonghua Gao, Rongchang Chen and Zhe Cheng Source Type: research

Chronic heart failure modifies respiratory mechanics in rats: a randomized controlled trial
Conclusion Rats with CHF present important changes in hemodynamic and respiratory mechanics, which may be associated with alterations in cardiopulmonary interactions. (Source: Revista Brasileira de Fisioterapia)
Source: Revista Brasileira de Fisioterapia - August 23, 2016 Category: Physiotherapy Source Type: research

An Acute Respiratory Infection of a Physiologically Anemic Infant is a More Likely Cause of SIDS than Neurological Prematurity
David T. Mage, Maria Luisa Latorre, Alejandro G. Jenik, E. Maria Donner (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - August 23, 2016 Category: Neurology Source Type: research

Nifedipine maintenance tocolysis and perinatal outcome: an individual participant data meta ‐analysis
ConclusionMaintenance tocolysis is not associated with improved perinatal outcome and is therefore not recommended for routine practice. Tweetable abstractNifedipine maintenance tocolysis is not associated with improved perinatal outcome or pregnancy prolongation. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - August 23, 2016 Category: OBGYN Authors: EOG Vliet, GH Dijkema, E Schuit, KY Heida, C Roos, JAM Post, EC Parry, L McCowan, DJ Lyell, YY El ‐Sayed, DB Carr, AL Clark, ZA Mahdy, M Uma, NC Sayin, GF Varol, BW Mol, MA Oudijk Tags: Systematic review Source Type: research

The relationship of body habitus and respiratory function in Duchenne muscular dystrophy
The multidisciplinary care of Duchenne Muscular Dystrophy (DMD) incorporates management of nutrition and the respiratory system, however the effect of body habitus on respiratory function in DMD is poorly understood. The present study examined the impact of nutritional status on respiratory function in DMD to guide further treatment strategies. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 23, 2016 Category: Respiratory Medicine Authors: Kenneth Chew, Kate Carey, Genevieve Ho, Kylie-Ann Mallitt, John Widger, Michelle Farrar Source Type: research

Ethnic and socio-economic differences in the prevalence of wheeze, severe wheeze, asthma, eczema and medication usage at 4 years of age: Findings from the born in Bradford birth cohort
Asthma, wheeze and eczema are common in early childhood and cause considerable morbidity. Generally rates of these conditions are higher in high income compared to low income countries. Rates in developed nations are generally higher than in less developed countries. After migration to Western countries, differences in risks of developing these conditions may between migrant and non-migrant may diminish. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 23, 2016 Category: Respiratory Medicine Authors: Emily S. Petherick, Neil Pearce, Jordi Sunyer, John Wright Source Type: research

Respiratory pattern in a FSHD pediatric population
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant inherited disorder characterized by selective weakness of face and upper arms and girdle. Respiratory involvement in FSHD has been described mainly in the most severely affected patients. In this work we tested the respiratory function by spirometry in 12 patients affected by FSHD with onset before 18 years. Spirometry results were correlated with motor involvement and compared to aged matched group of Becker patients. Of note FSHD patients present a peculiar pattern characterized by a flat shape in flow-volume loop. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 23, 2016 Category: Respiratory Medicine Authors: Federica Trucco, Marina Pedemonte, Chiara Fiorillo, Paola Tacchetti, Giacomo Brisca, Claudio Bruno, Carlo Minetti Tags: Short communication Source Type: research

Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique
Bronchodilator response (BDR) analyzed by the raised volume rapid thoracic compression (RVRTC) in wheezing infants is not yet well described, although bronchodilators (BD) are routine in the treatment of this population. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 23, 2016 Category: Respiratory Medicine Authors: Fernanda Cordoba Lanza, Gustavo Falbo Wandalsen, Amelia Miyashiro Nunes dos Santos, Dirceu Sol é Source Type: research

Updating a gas dynamics model using estimates for California sea lions (Zalophus californianus)
Publication date: Available online 22 August 2016 Source:Respiratory Physiology & Neurobiology Author(s): Matthew R. Hodanbosi, Blair Sterba-Boatwright, Andreas Fahlman Theoretical models are used to predict how breath-hold diving vertebrates manage O2, CO2, and N2 while underwater. One recent gas dynamics model used available lung and tracheal compliance data from various species. As variation in respiratory compliance significantly affects alveolar compression and pulmonary shunt, the current study objective was to evaluate changes in model output when using species-specific parameters from California sea lions ...
Source: Respiratory Physiology and Neurobiology - August 23, 2016 Category: Respiratory Medicine Source Type: research

The neural control of respiration in lampreys
Publication date: Available online 22 August 2016 Source:Respiratory Physiology & Neurobiology Author(s): Kianoush Missaghi, Jean-Patrick Le Gal, Paul A. Gray, Réjean Dubuc This review focuses on past and recent findings that have contributed to characterize the neural networks controlling respiration in the lamprey, a basal vertebrate. As in other vertebrates, respiration in lampreys is generated centrally in the brainstem. It is characterized by the presence of a fast and a slow respiratory rhythm. The anatomical and the basic physiological properties of the neural networks underlying the generation of the fast...
Source: Respiratory Physiology and Neurobiology - August 23, 2016 Category: Respiratory Medicine Source Type: research