Significantly Different Contact Patterns between A β40 and Aβ42 Monomers Involving the N‐Terminal Region
Chemical Biology&Drug Design,Volume 0, Issue ja, -Not available-. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - November 1, 2018 Category: Biology Authors: Ziye Liu,
Fan Jiang,
Yun ‐Dong Wu Source Type: research
MedPServer: a database for identification of therapeutic targets & novel leads pertaining to natural products
Chemical Biology&Drug Design,Volume 0, Issue ja, -Not available-. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - November 1, 2018 Category: Biology Authors: Angamba Meetei Potshangbam,
Raja Polavarapu,
R.S. Rathore,
Naresh Damuka,
N Prakash Prabhu,
Nongdam Potshangbam,
Pravind Kumar,
Vaibhav Vindal Source Type: research
Design, Synthesis, and Biological Evaluation of Thieno[3,2 ‐d]pyrimidine Derivatives as Potential Simplified Phosphatidylinositol 3‐Kinase alpha (PI3Kα) inhibitors
Chemical Biology&Drug Design,Volume 0, Issue ja, -Not available-. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - November 1, 2018 Category: Biology Authors: Xiuyan Yang,
Meng Deng,
Xi Zhang,
Kun Song,
Cong Ruan,
Linghua Meng,
Jian Zhang Source Type: research
Discovery of potent HIV ‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure‐activity relationship of solvent‐exposed regions I
Chemical Biology&Drug Design,Volume 0, Issue ja, -Not available-. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - November 1, 2018 Category: Biology Authors: Dongwei Kang,
Zhao Wang,
Meng Chen,
Da Feng,
Gaochan Wu,
Zhongxia Zhou,
Lanlan Jing,
Xiaofang Zuo,
Xiangyi Jiang,
Dirk Daelemans,
Erik De Clercq,
Christophe Pannecouque,
Peng Zhan,
Xinyong Liu Source Type: research
Preliminary application of micro ‐SPECT/CT imaging by 99mTc‐tricine‐EDDA‐Hynic‐c‐Met for non‐small‐cell lung cancer
Chemical Biology&Drug Design,Volume 0, Issue ja, -Not available-. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - November 1, 2018 Category: Biology Authors: Yiqiu Zhang,
Lanfang Meng,
Beilei Li,
Hui Tan,
Qing ‐Yu Lin,
Dengfeng Cheng,
Hongcheng Shi Source Type: research
Q817G mutation in phosphodiesterase type 5 (PDE ‐5): conformational analysis and dissociation profile of the inhibitor Tadalafil
Chemical Biology&Drug Design,Volume 0, Issue ja, -Not available-. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - November 1, 2018 Category: Biology Authors: Ivan Pires de Oliveira,
Caroline Honaiser Lescano,
Gilberto De Nucci Source Type: research
Design, synthesis, and biological activity evaluation of campthothecin ‐HAA‐Norcantharidin conjugates as antitumor agents in vitro
Three components of Camptothecin, hydroxyacetic acid, and functionalizednorcantharidins were constructed together to form a novel series ofcamptothecin derivatives in a good yield. The synthesized campthothecin ‐HAA‐norcantharidin conjugate pro‐drugs could suppress cancer cell growth in vitro. These conjugated pro‐drug molecules possess therapeutic potential as novel bi‐functional conjugates platforms for cancer treatment. Three components of Camptothecin, hydroxyacetic acid, and functionalizednorcantharidins were constructed together to form a novel series ofcamptothecin derivatives in a good yield. The synthesi...
Source: Chemical Biology and Drug Design - October 31, 2018 Category: Biology Authors: Xian H. Wang,
Mei Huang,
Chang K. Zhao,
Chan Li,
Lang Xu Tags: SPECIAL ISSUE ARTICLE Source Type: research
Secochiliolide ester derivatives: Preparation and evaluation of their antitrypanosomal and antimalarial efficacy
A series of new esters of secochiliolide acid (SA) were synthesized and evaluated for their in vitro antiparasitic properties (onPlasmodium falciparum andTrypanosoma brucei brucei). The in vivo antimalarial efficacy of then‐hexyl ester of SA was assessed on mice. An intraperitoneal treatment at 50 mg kg−1 day−1 induced 56.0 ± 8.2% of parasitaemia reduction on day 4 post‐infection and an increase on the survival time. AbstractIn the present study, a series of new esters of secochiliolide acid (SA), a diterpene isolated fromNardophyllum bryoides, were synthesized in good yield. All compounds were evaluated for...
Source: Chemical Biology and Drug Design - October 31, 2018 Category: Biology Authors: Romina J. Ronchi,
Claire Beaufay,
Joanne Bero,
Juan B. Robirosa,
Marcia Mazzuca,
Jorge A. Palermo,
Jo ëlle Quetin‐Leclercq,
Marianela Sánchez Tags: RESEARCH ARTICLE Source Type: research
Discovery of potent HIV ‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure‐activity relationship of solvent‐exposed regions I
This article is protected by copyright. All rights reserved. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - October 31, 2018 Category: Biology Authors: Dongwei Kang,
Zhao Wang,
Meng Chen,
Da Feng,
Gaochan Wu,
Zhongxia Zhou,
Lanlan Jing,
Xiaofang Zuo,
Xiangyi Jiang,
Dirk Daelemans,
Erik De Clercq,
Christophe Pannecouque,
Peng Zhan,
Xinyong Liu Tags: Research Article Source Type: research
Design, Synthesis, and Biological Evaluation of Thieno[3,2 ‐d]pyrimidine Derivatives as Potential Simplified Phosphatidylinositol 3‐Kinase alpha (PI3Kα) inhibitors
This article is protected by copyright. All rights reserved. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - October 31, 2018 Category: Biology Authors: Xiuyan Yang,
Meng Deng,
Xi Zhang,
Kun Song,
Cong Ruan,
Linghua Meng,
Jian Zhang Tags: Research Article Source Type: research
Q817G mutation in phosphodiesterase type 5 (PDE ‐5): conformational analysis and dissociation profile of the inhibitor Tadalafil
This article is protected by copyright. All rights reserved. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - October 31, 2018 Category: Biology Authors: Ivan Pires de Oliveira,
Caroline Honaiser Lescano,
Gilberto De Nucci Tags: Research Article Source Type: research
MedPServer: a database for identification of therapeutic targets & novel leads pertaining to natural products
This article is protected by copyright. All rights reserved. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - October 31, 2018 Category: Biology Authors: Angamba Meetei Potshangbam,
Raja Polavarapu,
R.S. Rathore,
Naresh Damuka,
N Prakash Prabhu,
Nongdam Potshangbam,
Pravind Kumar,
Vaibhav Vindal Tags: Research Article Source Type: research
Significantly Different Contact Patterns between A β40 and Aβ42 Monomers Involving the N‐Terminal Region
This article is protected by copyright. All rights reserved. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - October 31, 2018 Category: Biology Authors: Ziye Liu,
Fan Jiang,
Yun ‐Dong Wu Tags: Research Article Source Type: research
Preliminary application of micro ‐SPECT/CT imaging by 99mTc‐tricine‐EDDA‐Hynic‐c‐Met for non‐small‐cell lung cancer
ConclusionMicro ‐SPECT/CT imaging through99mTc ‐tricine‐EDDA‐Hynic‐c‐Met can be used to screen c‐Met indicators of NSCLC in H1993 nude mice models for targeted drug therapy.This article is protected by copyright. All rights reserved. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - October 31, 2018 Category: Biology Authors: Yiqiu Zhang,
Lanfang Meng,
Beilei Li,
Hui Tan,
Qing ‐Yu Lin,
Dengfeng Cheng,
Hongcheng Shi Tags: Research Article Source Type: research
Secochiliolide ester derivatives: Preparation and evaluation of their antitrypanosomal and antimalarial efficacy
Chemical Biology&Drug Design, EarlyView. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - October 31, 2018 Category: Biology Authors: Romina J. Ronchi,
Claire Beaufay,
Joanne Bero,
Juan B. Robirosa,
Marcia Mazzuca,
Jorge A. Palermo,
Jo ëlle Quetin‐Leclercq,
Marianela Sánchez Source Type: research
