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Late season pharmaceutical fate in wetland mesocosms with and without phosphorous addition.
Abstract The fate of six human-use drugs was assessed and predicted in mesocosms designed to mimic shallow constructed wetlands during the onset of fall and senescence. Mesocosms were monitored for 28 days after the addition of carbamazepine, clofibric acid, fluoxetine and naproxen (nominal initial concentrations of 5 μg/L each), sulfamethoxazole, and sulfapyridine (nominal initial concentrations of 150 μg/L each), with and without phosphorous (P) addition at 1.6 mg/L. We hypothesized that addition of P would stimulate primary productivity and enhance removal of pharmaceuticals from the water column. Carbama...
Source: Environmental Science and Pollution Research International - August 25, 2016 Category: Environmental Health Authors: Cardinal P, Anderson JC, Carlson JC, Low JE, Challis JK, Wong CS, Hanson ML Tags: Environ Sci Pollut Res Int Source Type: research

Mechanically tuned nanocomposite coating on titanium metal with integrated properties of biofilm inhibition, cell proliferation, sustained drug delivery
Publication date: Available online 21 August 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Sandeep K. Mishra, Arun K. Teotia, Ashok Kumar, Sanjeevi Kannan The clinical success of coated implants in executing biological functions inclusive of sustainable drug release and long term antibacterial activity without antibiotics is critical. To this aim, a nanohybrid of silver nanoparticles (AgNPs) cored polyvinyl alcohol nanocapsules (Ag-PVA NCs) embedded in chitosan (CS) matrix loaded with anti-inflammatory drug naproxen was prepared. The synthesized nanohybrids that were subjected to coatings on (3...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - August 22, 2016 Category: Nanotechnology Source Type: research

Analgesic Efficacy of a New, Immediate ‐Release/Extended‐Release Formulation of Ibuprofen: Results from Single‐ and Multiple‐Dose Postsurgical Dental Pain Studies
This article is protected by copyright. All rights reserved (Source: Clinical Pharmacology in Drug Development)
Source: Clinical Pharmacology in Drug Development - August 22, 2016 Category: Drugs & Pharmacology Authors: Steven Christensen, Ed Paluch, Shyamalie Jayawardena, Stephen Daniels, Suzanne Meeves Tags: Original Manuscript Source Type: research

Innovative combination of QuEChERS extraction with on-line solid-phase extract purification and pre-concentration, followed by liquid chromatography-tandem mass spectrometry for the determination of non-steroidal anti-inflammatory drugs and their metabolites in sewage sludge.
Abstract For the first time QuEChERS extraction of sewage sludge was combined with the automatic solid-phase pre-concentration and purification of the extract (following indicated as SPE) and LC-MS/MS analysis, for the determination of the non-steroidal anti-inflammatory drugs acetylsalicylic acid (ASA), diclofenac (DIC), fenbufen (FEN), flurbiprofen (FLU), ketoprofen (KET), ibuprofen (IBU) and naproxen (NAP), and their metabolites salicylic acid (SAL), 4'-hydroxydiclofenac (4'-HYDIC), 1-hydroxyibuprofen (1-HYIBU), 2-hydroxyibuprofen (2-HYIBU), 3-hydroxyibuprofen (3-HYIBU) and o-desmethylnaproxen (O-DMNAP). Variou...
Source: Analytica Chimica Acta - August 21, 2016 Category: Chemistry Authors: Rossini D, Ciofi L, Ancillotti C, Checchini L, Bruzzoniti MC, Rivoira L, Fibbi D, Orlandini S, Del Bubba M Tags: Anal Chim Acta Source Type: research

Mechanically tuned nanocomposite coating on titanium metal with integrated properties of biofilm inhibition, cell proliferation, sustained drug delivery
The clinical success of coated implants in executing biological functions inclusive of sustainable drug release and long term antibacterial activity without antibiotics is critical. To this aim, a nanohybrid of silver nanoparticles (AgNPs) cored polyvinyl alcohol nanocapsules (Ag-PVA NCs) embedded in chitosan (CS) matrix loaded with anti-inflammatory drug naproxen was prepared. The synthesized nanohybrids that were subjected to coatings on (3-amino propyl) triethoxysilane (APTES) treated Titanium (Ti) metal exhibited dual role of excellent inhibition on biofilm formation and sustained drug release. (Source: Nanomedicine : ...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - August 21, 2016 Category: Nanotechnology Authors: Sandeep K. Mishra, Arun K. Teotia, Ashok Kumar, Sanjeevi Kannan Source Type: research

Enantioselective simultaneous analysis of selected pharmaceuticals in environmental samples by ultrahigh performance supercritical fluid based chromatography tandem mass spectrometry.
Abstract In order to assess the true impact of each single enantiomer of pharmacologically active compounds (PACs) in the environment, highly efficient, fast and sensitive analytical methods are needed. For the first time this paper focuses on the use of ultrahigh performance supercritical fluid based chromatography coupled to a triple quadrupole mass spectrometer to develop multi-residue enantioselective methods for chiral PACs in environmental matrices. This technique exploits the advantages of supercritical fluid chromatography, ultrahigh performance liquid chromatography and mass spectrometry. Two coated modif...
Source: Analytica Chimica Acta - August 13, 2016 Category: Chemistry Authors: Camacho-Muñoz D, Kasprzyk-Hordern B, Thomas KV Tags: Anal Chim Acta Source Type: research

Magnetic field assisted μ-solid phase extraction of anti-inflammatory and loop diuretic drugs by modified polybutylene terephthalate nanofibers.
Abstract A magnetic nanocomposite consisting of nanoparticles-polybutylene terephthalate (MNPs-PBT) was electrospun and used as an extracting medium for an on-line μ-solid phase extraction (μ-SPE)-high performance liquid chromatography (HPLC) set-up with an ultraviolet (UV) detection system. Due to the magnetic property of the prepared nanofibers, the whole extraction procedure was implemented under an external magnetic field to enhance the extraction efficiencies. The developed method along with the synthesized nanocomposite were found to be appropriate for the determination of trace levels of selected drugs in...
Source: Analytica Chimica Acta - August 13, 2016 Category: Chemistry Authors: Bagheri H, Khanipour P, Asgari S Tags: Anal Chim Acta Source Type: research

Determination of non-steroidal anti-inflammatory drugs in water and urine using selective molecular imprinted polymer extraction and liquid chromatography
Publication date: 30 November 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 131 Author(s): Teresa Martinez-Sena, Sergio Armenta, Miguel de la Guardia, Francesc A. Esteve-Turrillas A selective solid-phase extraction was employed for the improvement of the determination of non-steroidal anti-inflammatory drugs (NSAIDs) in continental water and urine samples. Ketoprofen, naproxen, diclofenac, and ibuprofen were selected as target analytes due to they are the most frequently administered and consumed NSAIDs. These compounds were extracted using molecular imprinted polymers and determined by liquid chro...
Source: Journal of Pharmaceutical and Biomedical Analysis - August 11, 2016 Category: Drugs & Pharmacology Source Type: research

Newly Approved Agents for the Treatment and Prevention of Pediatric Migraine
AbstractTreatment of pediatric migraine remains an unmet medical need. There continues to be a paucity of pediatric randomized controlled trials for the treatment of migraine, both in the acute and preventive settings. Pediatric studies are often complicated by high placebo-response rates and much of our current practice is based on adult trials. This lack of significant pediatric studies results in a wide variation in migraine management both amongst clinicians and between institutions, and evidence-based treatments are not always administered. In this article, we aim to briefly review newly approved abortive and preventi...
Source: CNS Drugs - August 8, 2016 Category: Neurology Source Type: research

Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill
Publication date: 25 September 2016 Source:International Journal of Pharmaceutics, Volume 511, Issue 2 Author(s): Denise Steiner, Jan Henrik Finke, Arno Kwade Orodispersible films possess a great potential as a versatile platform for nanoparticle-loaded oral dosage forms. In this case, poorly water-soluble organic materials were ground in a stirred media mill and embedded into a polymer matrix. The aim of this study was the shortening of this manufacturing process by the integration of several process steps into a stirred media mill without facing disadvantages regarding the film quality. Furthermore, this process integra...
Source: International Journal of Pharmaceutics - August 7, 2016 Category: Drugs & Pharmacology Source Type: research

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties.
Conclusion. The present study demonstrated that copper, cobalt, and zinc complexes possess higher antinociceptive, anxiolytic, CNS depressant, and hypoglycemic properties than the parent ligand. PMID: 27478435 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - August 3, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Differences in Esterase Activity to Aspirin and p-Nitrophenyl Acetate among Human Serum Albumin Preparations.
Abstract Human serum albumin (HSA) has two major ligand-binding sites, sites I and II, and also hydrolyzes some compounds at both sites. In the present study, we investigated differences in esterase activity among HSA preparations, and also the effects of warfarin, indomethacin, and naproxen on the hydrolytic activities of HSA to aspirin and p-nitrophenyl acetate. The esterase activities of HSA to aspirin or p-nitrophenyl acetate were measured from the pseudo-first-order formation rate constant (kobs) of salicylic acid or p-nitrophenol by HSA. Inter-lot variations were observed in the esterase activities of HSA to...
Source: Biological and Pharmaceutical Bulletin - August 2, 2016 Category: Drugs & Pharmacology Authors: Tatsumi A, Okada M, Inagaki Y, Inoue S, Hamaguchi T, Iwakawa S Tags: Biol Pharm Bull Source Type: research

Repurposing FDA-approved drugs for anti-aging therapies.
Abstract There is great interest in drugs that are capable of modulating multiple aging pathways, thereby delaying the onset and progression of aging. Effective strategies for drug development include the repurposing of existing drugs already approved by the FDA for human therapy. FDA approved drugs have known mechanisms of action and have been thoroughly screened for safety. Although there has been extensive scientific activity in repurposing drugs for disease therapy, there has been little testing of these drugs for their effects on aging. The pool of FDA approved drugs therefore represents a large reservoir of ...
Source: Biogerontology - August 2, 2016 Category: Geriatrics Authors: Snell TW, Johnston RK, Srinivasan B, Zhou H, Gao M, Skolnick J Tags: Biogerontology Source Type: research

Multifocal pigmented villonodular synovitis in a child: A case report
Conclusions: PVNS was easily misdiagnosed as rheumatoid arthritis and the formal treatment was usually delayed. This case described here is the first case of PVNS involving such a large numbers of joints that has been reported in the literature. (Source: Medicine)
Source: Medicine - August 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Brief Report: Course of Active Inflammatory and Fatty Lesions in Patients With Early Axial Spondyloarthritis Treated With Infliximab Plus Naproxen as Compared to Naproxen Alone: Results From the Infliximab As First Line Therapy in Patients with Early Active Axial Spondyloarthritis Trial
ConclusionThese findings indicate that effective antiinflammatory treatment of axial SpA is associated with an increase in fatty lesion scores, independent of concomitant treatment with or without anti‐TNF. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - July 27, 2016 Category: Rheumatology Authors: Denis Poddubnyy, Joachim Listing, Joachim Sieper Tags: Spondyloarthritis Source Type: research

Use of Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Relation to Cardiovascular Events: A Systematic Pharmacoepidemiological Review.
CONCLUSION: Further research is needed in order to devise new guidelines for safer use of NSAIDs. PMID: 27468710 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - July 27, 2016 Category: Drugs & Pharmacology Authors: Kontogiorgis C, Valikeserlis I, Hadjipavlou-Litina D, Nena E, Constantinidis TC Tags: Curr Vasc Pharmacol Source Type: research

Loxoprofen: A Review in Pain and Inflammation
Abstract Loxoprofen (Loxonin ® , Loxonin ® Pap, Loxonin ® Tape) is a prodrug-type NSAID that is available in several formulations, including 60  mg tablets, 100 mg hydrogel patches and 50 or 100 mg tape. In active comparator-controlled trials, oral loxoprofen therapy (ranging from 2 days to 6 weeks’ duration depending on the pain type) provided analgesic efficacy that generally did not significantly differ from that of celecoxib for po stoperative pain or frozen shoulder, ibuprofen for knee osteoarthritis or naproxen for lumbar pain. In double-blind, double-dummy, multicentre trials, loxoprofen hydrogel patches ...
Source: Clinical Drug Investigation - July 21, 2016 Category: Drugs & Pharmacology Source Type: research

Liquid chromatography–tandem mass spectrometry and passive sampling: powerful tools for the determination of emerging pollutants in water for human consumption
Among the wide range of emerging pollutants, perfluorinated compounds and various pharmaceuticals, such as nonsteroidal anti‐inflammatory drugs (NSAIDs), are showing growing concern. These contaminants can be found in freshwater ecosystems due to their incomplete removal during wastewater treatments so, their water solubility and poor degradability result in their continuous discharge and pseudo‐persistent contamination. Usually, expected levels of these analytes are particularly low, therefore sensitive and selective analytical techniques are required for their determination. Moreover, sampling and preconcentration ar...
Source: Journal of Mass Spectrometry - July 15, 2016 Category: Chemistry Authors: Cristiana Mirasole, Marina Di Carro, Shivani Tanwar, Emanuele Magi Tags: Research article Source Type: research

Liquid chromatography –tandem mass spectrometry and passive sampling: powerful tools for the determination of emerging pollutants in water for human consumption
Among the wide range of emerging pollutants, perfluorinated compounds and various pharmaceuticals, such as nonsteroidal anti‐inflammatory drugs (NSAIDs), are showing growing concern. These contaminants can be found in freshwater ecosystems due to their incomplete removal during wastewater treatments so, their water solubility and poor degradability result in their continuous discharge and pseudo‐persistent contamination. Usually, expected levels of these analytes are particularly low, therefore sensitive and selective analytical techniques are required for their determination. Moreover, sampling and preconcentration ar...
Source: Journal of Mass Spectrometry - July 14, 2016 Category: Chemistry Authors: Cristiana Mirasole, Marina Di Carro, Shivani Tanwar, Emanuele Magi Tags: Research article Source Type: research

Fabrication of a nano-drug delivery system based on layered rare-earth hydroxides integrating drug-loading and fluorescence properties
Dalton Trans., 2016, Advance ArticleDOI: 10.1039/C6DT01875K, PaperQingyang Gu, Wen Chen, Fei Duan, Ruijun JuIntercalation of naproxen (NPX) into LEuH to form nanocomposites with low cytotoxic effects, which can control the release of NPX.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - July 12, 2016 Category: Chemistry Authors: Qingyang Gu Source Type: research

The Potent Inhibitory Effect of a Naproxen-Appended Cobalt(III)-Cyclam Complex on Cancer Stem Cells.
We report the cancer stem cell (CSC) potency of a novel cobalt(III)-cyclam complex, 1 bearing the nonsteroidal anti-inflammatory drug, naproxen. The cobalt(III)-cyclam complex, 1 displays selective potency for breast CSC-enriched HMLER-shEcad cells over breast CSC-depleted HMLER cells. Additionally, 1 inhibits the formation of three-dimensional tumor-like mammospheres, and reduces their viability to a greater extent than clinically used breast cancer drugs; vinorelbine, cisplatin, and paclitaxel. The mammosphere-potency of 1 was enhanced in hypoxia-mimicking conditions. Detailed mechanistic studies revealed that DNA damage...
Source: Chembiochem - July 5, 2016 Category: Biochemistry Authors: Cressey P, Eskandari A, Bruno P, Lu C, Hemann M, Suntharalingam K Tags: Chembiochem Source Type: research

Fabrication of nano-drug delivery system based layered rare-earth hydroxides integrating drug-loading and fluorescence properties
Dalton Trans., 2016, Accepted ManuscriptDOI: 10.1039/C6DT01875K, PaperQingyang Gu, Wen Chen, Fei Duan, Ruijun JuWe demonstrate the first example of intercalation naproxen (abbr. NPX) into layered europium hydroxide (LEuH) and investigate the structure, chemical composition, thermostability, morphology, luminescence property, cytotoxic effect, and controlled-release behaviors....The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - July 4, 2016 Category: Chemistry Authors: Qingyang Gu Source Type: research

Size effects of multi-walled carbon nanotubes on the electrochemical oxidation of propionic acid derivative drugs: Ibuprofen and naproxen
Publication date: 15 August 2016 Source:Journal of Electroanalytical Chemistry, Volume 775 Author(s): Rodrigo H.O. Montes, Ana P. Lima, Rafael R. Cunha, Tiago J. Guedes, Wallans T.P. dos Santos, Edson Nossol, Eduardo M. Richter, Rodrigo A.A. Munoz The superior electrochemical activity of multi-walled carbon nanotubes (MWCNTs) of shorter dimensions towards the oxidation of propionic acid derivative drugs, namely ibuprofen (IBF) and naproxen (NPX), is presented. A glassy-carbon electrode was modified with MWCNTs of different sizes (diameter×length: 100–170nm×5–9μm and 6–9nm×5μm, corresponding to LD- and ...
Source: Journal of Electroanalytical Chemistry - July 2, 2016 Category: Chemistry Source Type: research

Case Report: Industrial X-Ray Injury Treated With Non-Cultured Autologous Adipose-Derived Stromal Vascular Fraction (SVF)
Abstract: Local cutaneous injuries induced by ionizing radiation (IR) are difficult to treat. Many have reported local injection of adipose-derived stromal vascular fraction (SVF), often with additional therapies, as an effective treatment of IR-induced injury even after other local therapies have failed. The authors report a case of a locally recurrent, IR-induced wound that was treated with autologous, non-cultured SVF without other concurrent therapy. A nondestructive testing technician was exposed to 130 kVp x rays to his non-dominant right thumb on 5 October 2011. The wound healed 4 mo after initial conservative thera...
Source: Health Physics - July 1, 2016 Category: Radiology Tags: Papers Source Type: research

A detailed in vitro study of naproxen metal complexes in quest of new therapeutic possibilities
Conclusion The present study demonstrated that Naproxen and its complexes possess in vitro anti-inflammatory activity while silver, zinc and iron complexes possess higher antimicrobial and cytotoxic properties than the parent ligand and possess very mild antioxidant activity. (Source: Alexandria Journal of Medicine)
Source: Alexandria Journal of Medicine - July 1, 2016 Category: Journals (General) Source Type: research

Photoinduced Target ‐like Drug Reaction to Naproxen
This article is protected by copyright. All rights reserved. (Source: Photodermatology, Photoimmunology and Photomedicine)
Source: Photodermatology, Photoimmunology and Photomedicine - July 1, 2016 Category: Radiology Authors: Lorena Barboza ‐Guadagnini, Julio Bassas‐Vila, Jose Aguilera, Carlos Ferrándiz, José‐Manuel Carrascosa Tags: Letter to the Editor Source Type: research

Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes
This report presents data on the interaction of the most consumed NSAIDs (ibuprofen, naproxen and diclofenac) with one main phospholipid in eukaryotic cells, dimyristoylphosphatidylserine (DMPS). The applied techniques are Fourier-transform infrared spectroscopy (FTIR), with which in transmission the gel to liquid crystalline phase transition of the acyl chains in the absence and presence of the NSAID are monitored, supplemented by differential scanning calorimetry (DSC) data on the phase transition. FTIR in reflection (ATR, attenuated total reflectance) is applied to record the dependence of the interactions of the NSAID ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - June 28, 2016 Category: Biochemistry Source Type: research

Accessing the Physical State and Molecular Mobility of Naproxen Confined to Nanoporous Silica Matrixes
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.6b04078 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - June 24, 2016 Category: Chemistry Authors: Teresa Cordeiro, Andreia F. M. Santos, Guilherme Nunes, Guilherme Cunha, João C. Sotomayor, Isabel M. Fonseca, Florence Danède, C. J. Dias, M. Margarida Cardoso, Natália T. Correia, M. Teresa Viciosa and Madalena Dionísio Source Type: research

Acute toxicity and histopathological effects of naproxen in zebrafish (Danio rerio) early life stages.
Abstract Zebrafish (Danio rerio) embryos and larvae were selected to investigate the potential risk and aquatic toxicity of a widely used pharmaceutical, naproxen. The acute toxicity of naproxen to embryos and larvae was measured, respectively. The histopathology was investigated in the liver of zebrafish larvae after 8-day embryo-larvae exposure to naproxen. The values of 96-h LC50 were 115.2 mg/L for embryos and 147.6 mg/L for larvae, indicating that zebrafish embryos were more sensitive than larvae to naproxen exposure. Large suites of symptoms were induced in zebrafish (D. rerio) early life stages by differe...
Source: Environmental Science and Pollution Research International - June 18, 2016 Category: Environmental Health Authors: Li Q, Wang P, Chen L, Gao H, Wu L Tags: Environ Sci Pollut Res Int Source Type: research

0053 : Naproxen as an alternative to aspirin for platelet inhibition in patients with cardiovascular disease requiring nonsteroidal anti-inflammatory drug?
Conclusion Naproxen has a stable biological antiplatelet effect similar to aspirin. However, after naproxen or ibuprofen, aspirin was unable to inhibit platelet aggregation. These results suggest than NSAIDs could block the action of aspirin on platelets for several days. The author hereby declares no conflict of interest (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - June 16, 2016 Category: Cardiology Source Type: research

Arylhydrazone derivatives of naproxen as new analgesic and anti-inflammatory agents: Design, synthesis and molecular docking studies
Publication date: June 2016 Source:Journal of Molecular Graphics and Modelling, Volume 67 Author(s): Homa Azizian, Zahra Mousavi, Hamidreza Faraji, Mohammad Tajik, Kowsar Bagherzadeh, Peyman Bayat, Abbas Shafiee, Ali Almasirad A series of new arylidenehydrazone derivatives of naproxen were synthesized and evaluated for their analgesic and anti-inflammatory activities. Some of the synthesized analogues showed comparable activities when compared against naproxen for their analgesic and anti-inflammatory properties. 2-(6-methoxy-2-naphthyl)-N′-[(pyridine-4-yl)methylene]propanoic acid hydrazide 4j was found to be t...
Source: Journal of Molecular Graphics and Modelling - June 14, 2016 Category: Molecular Biology Source Type: research

Occurrence, fate and removal efficiencies of pharmaceuticals in wastewater treatment plants (WWTPs) discharging in the coastal environment of Algiers
Publication date: Available online 13 June 2016 Source:Comptes Rendus Chimie Author(s): Amine Elmouatezz Bellah Kermia, Djamila Fouial-Djebbar, Mohamed Trari In the last few decades, the presence of pharmaceutical products in the environment is known under the name of emerging contaminants. These substances can enter the aquatic environment via different sources, as parent compounds, metabolites or a combination of both. In this work, we have investigated the presence of four pharmaceutical active compounds belonging to the group of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), in wastewater, surface water and drink...
Source: Comptes Rendus Chimie - June 14, 2016 Category: Chemistry Source Type: research

Thermal Solvent-Free Method of Loading of Pharmaceutical Cocrystals into the Pores of Silica Particles: A Case of Naproxen/Picolinamide Cocrystal
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.6b05302 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - June 13, 2016 Category: Chemistry Authors: Ewa Skorupska, Agata Jeziorna and Marek J. Potrzebowski Source Type: research

Prediction of fetal ductus arteriosus constriction by systemic and local dermatological formulations of NSAIDs based on PK/PD analysis.
CONCLUSION: These results suggest that risk to the fetus should be carefully considered before administration of NSAIDs (especially systemic formulations, but including dermatological formulations) to women in the third trimester of pregnancy. PMID: 27285464 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - June 12, 2016 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Effects of kinesiotaping versus non-steroidal anti-inflammatory drugs and physical therapy for treatment of pes anserinus tendino-bursitis: A randomized comparative clinical trial.
CONCLUSION: Kinesiotaping is more effective than naproxen plus physical therapy in reduction of pain and swelling in patients with pes anserinus tendino-bursitis. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov identifier is NCT01680263. PMID: 27276165 [PubMed - as supplied by publisher] (Source: The Physician and Sportsmedicine Online)
Source: The Physician and Sportsmedicine Online - June 11, 2016 Category: Sports Medicine Tags: Phys Sportsmed Source Type: research

Challenge of the supercritical antisolvent technique SAS to prepare cocrystal-pure powders of naproxen-nicotinamide
Publication date: 1 November 2016 Source:Chemical Engineering Journal, Volume 303 Author(s): C. Neurohr, A. Erriguible, S. Laugier, P. Subra-Paternault Crystallization assisted by supercritical CO2 has been long ago developed for micronization purposes, but its application to fabricate cocrystals is in its infancy. In this work, the cocrystallization of naproxen and nicotinamide was investigated using CO2 as an antisolvent. In the so-called SAS technique (Supercritical AntiSolvent) a solution of the species dissolved in acetone was injected into a continuous flow of CO2. The conditions of temperature and pressure wer...
Source: Chemical Engineering Journal - June 11, 2016 Category: Chemistry Source Type: research

Naproxen, a Nonsteroidal Anti-Inflammatory Drug, Can Affect Daily Hypobaric Hypoxia-Induced Alterations of Monoamine Levels in Different Areas of the Brain in Male Rats
High Altitude Medicine & Biology Jun 2016, Vol. 17, No. 2: 133-140. (Source: High Altitude Medicine and Biology)
Source: High Altitude Medicine and Biology - June 9, 2016 Category: Sports Medicine Authors: Ananda Raj GoswamiGoutam DuttaTusharkanti Ghosh Source Type: research

Suppository naproxen reduces incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis: Randomized controlled trial.
CONCLUSION: Single dose of suppository naproxen administered immediately before ERCP reduces the incidence of PEP. PMID: 27275104 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2016 Category: Gastroenterology Authors: Mansour-Ghanaei F, Joukar F, Taherzadeh Z, Sokhanvar H, Hasandokht T Tags: World J Gastroenterol Source Type: research

Determination of ibuprofen, naproxen and diclofenac in aqueous samples using a multi-template molecularly imprinted polymer as selective adsorbent for solid-phase extraction
This study describes the application of multi-template molecularly imprinted polymer (MIP) as selective sorbent in the solid-phase extraction (SPE) of naproxen, ibuprofen and diclofenac from wastewater and river water. MIP was synthesized at 70°C by employing naproxen, ibuprofen and diclofenac as multi-templates, ethylene glycol dimethacrylate, 2-vinyl pyridine and toluene as cross-linker, functional monomer and porogen, respectively. Wastewater and river water samples (pH 2.5) were percolated through SPE cartridge packed with 50mg of the MIP. The cartridge was washed with 2mL of methanol-water 10:90% (v:v) prior to eluti...
Source: Journal of Pharmaceutical and Biomedical Analysis - June 5, 2016 Category: Drugs & Pharmacology Source Type: research

Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial
Rebamipide is a gastroprotective agent with promising results against gastric damage induced by non-steroidal anti-inflammatory drugs. The present study evaluated if rebamipide protects against naproxen-induce... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 4, 2016 Category: Gastroenterology Authors: Thiago Gagliano-Jucá, Ronilson A. Moreno, Tiago Zaminelli, Mauro Napolitano, Antônio Frederico N. Magalhães, Aloísio Carvalhaes, Miriam S. Trevisan, John L. Wallace and Gilberto De Nucci Source Type: research

Suitability of passive sampling for the monitoring of pharmaceuticals in Finnish surface waters.
Abstract The occurrence of five pharmaceuticals, consisting of four anti-inflammatory and one antiepileptic drug, was studied by passive sampling and grab sampling in northern Lake Päijänne and River Vantaa. The passive sampling was performed by using Chemcatcher® sampler with a SDB-RPS Empore disk as a receiving phase. In Lake Päijänne, the sampling was conducted during summer 2013 at four locations near the discharge point of a wastewater treatment plant and in the years 2013 and 2015 at four locations along River Vantaa. The samples were analyzed by liquid chromatography coupled to tandem mass spectrometry...
Source: Environmental Science and Pollution Research International - June 3, 2016 Category: Environmental Health Authors: Lindholm-Lehto PC, Ahkola HS, Knuutinen JS, Koistinen J, Lahti K, Vahtera H, Herve SH Tags: Environ Sci Pollut Res Int Source Type: research

Naproxen
(Source: Reactions Weekly)
Source: Reactions Weekly - June 1, 2016 Category: Drugs & Pharmacology Source Type: research

PURLs: More isn't better with acute low back pain treatment.
Abstract Adding cyclobenzaprine or oxycodone/acetaminophen to naproxen for the treatment of acute low back pain does nothing more than increase adverse effects. PMID: 27474822 [PubMed - as supplied by publisher] (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - June 1, 2016 Category: Practice Management Authors: Frazer K, Stevermer JJ Tags: J Fam Pract Source Type: research

Removal of pharmaceuticals from synthetic wastewater in an aerobic granular sludge membrane bioreactor and determination of the bioreactor microbial diversity.
Abstract Five types of pharmaceuticals and personal care products (PPCPs) substances were selected as pollutants in this study. The effects of the removal of these pollutants and the microbial succession process in a granular sludge membrane bioreactor (GMBR) were investigated. Results showed that wastewater containing PPCPs influenced the performance of granular sludge. The removal of the five PPCPs from the GMBR had different effects. The removal rates of prednisolone, norfloxacin and naproxen reached 98.5, 87.8 and 84 %, respectively. The degradation effect in the GMBR system was relatively lower for sulphamet...
Source: Applied Microbiology and Biotechnology - May 28, 2016 Category: Microbiology Authors: Wang XC, Shen JM, Chen ZL, Zhao X, Xu H Tags: Appl Microbiol Biotechnol Source Type: research

Solar photolysis versus TiO2-mediated solar photocatalysis: a kinetic study of the degradation of naproxen and diclofenac in various water matrices.
This study showed that the solar light intensity and the water matrix appear to be the main factors influencing the overall performance of the solar photolysis and TiO2-mediated solar photocatalysis for degradation of DCF and NPX mixtures. PMID: 27230148 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - May 26, 2016 Category: Environmental Health Authors: Kanakaraju D, Motti CA, Glass BD, Oelgemöller M Tags: Environ Sci Pollut Res Int Source Type: research

Arylhydrazone Derivatives of Naproxen as NewAnalgesic and Anti-Inflammatory Agents: Design, Synthesis and Molecular Docking Studies
Publication date: Available online 24 May 2016 Source:Journal of Molecular Graphics and Modelling Author(s): Homa Azizian, Zahra Mousavi, Hamidreza Faraji, Mohammad Tajik, Kowsar Bagherzadeh, Peyman Bayat, Abbas Shafiee, Ali Almasirad A series of new arylidenehydrazone derivatives of naproxen were synthesized and evaluated for their analgesic and anti-inflammatory activities. Some of the synthesized analogues showed comparable activities when compared against naproxen for their analgesic and anti-inflammatory properties. 2-(6-methoxy-2-naphthyl)-N′-[(pyridine-4-yl)methylene]propanoic acid hydrazide 4j was found...
Source: Journal of Molecular Graphics and Modelling - May 24, 2016 Category: Molecular Biology Source Type: research

Curcumin Blocks Naproxen-induced Gastric Antral Ulcerations through Inhibition of Lipid Peroxidation and Activation of Enzymatic Scavengers in Rats.
Abstract Curcumin is a polyphenol derived from the plant Curcuma longa, which is used for the treatment of diseases associated with oxidative stress and inflammation. The present study was undertaken to determine the protective effect of curcumin against naproxen-induced gastric antral ulcerations in rats. Different doses (10, 50, and 100 mg/kg) of curcumin or vehicle (curcumin, 0 mg/kg) were pretreated for 3 days by oral gavage, and then gastric mucosal lesions were caused by 80 mg/kg naproxen applied for 3 days. Curcumin significantly inhibited naproxen-induced gastric antral ulcer area and lipid peroxidation in...
Source: Journal of Microbiology and Biotechnology - May 20, 2016 Category: Biotechnology Authors: Kim JH, Jin S, Kwon HJ, Kim BW Tags: J Microbiol Biotechnol Source Type: research

Severe ocular side effects with acetazolamide: case report.
CONCLUSION: This was an iatrogenic case of acute angle closure induced by an anterior displacement of the irido-lenticular complex, secondary to the use of acetazolamide. The treatment of this condition involves suspending the drug responsible and applying topical corticosteroids, hypotensive and cycloplegic eye drops, with the aim of lowering the eye pressure and the degree of myopia due to the re-positioning of the irido-lenticular complex. PMID: 27179669 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)
Source: Archivos de la Sociedad Espanola de Oftalmologia - May 18, 2016 Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

Use of non-steroidal anti-inflammatory drugs correlates with the risk of venous thromboembolism in knee osteoarthritis patients: a UK population-based case-control study
Conclusion. Compared with the remote users of NSAIDs, the risk of VTE increased for current users of diclofenac, ibuprofen, meloxicam, and coxibs, but not for naproxen, in the knee OA population. Clinicians should consider the risk profile for specific NSAIDs when recommending their use. (Source: Rheumatology)
Source: Rheumatology - May 17, 2016 Category: Rheumatology Authors: Lee, T., Lu, N., Felson, D. T., Choi, H. K., Dalal, D. S., Zhang, Y., Dubreuil, M. Tags: Osteoarthritis and Cartilage CLINICAL SCIENCE Source Type: research

Effects of reclaimed water matrix on fate of pharmaceuticals and personal care products in soil.
Abstract Reclaimed water is increasingly used to supplement water resources. However, reclaimed water has a complex matrix, which includes emerging chemical contaminants, that is introduced to the soil when this water is used for irrigation. The effects of microbial activity, dissolved matter, nutrients, and particulate matter in reclaimed water on half-life of 11 pharmaceutical and personal care products (PPCPs) in soil were investigated with 7 treatment waters, namely swine lagoon effluent (either unaltered, sterilized, or filtered and sterilized) and nanopure water (either unaltered or with added nitrogen, phos...
Source: Chemosphere - May 12, 2016 Category: Chemistry Authors: Dodgen LK, Zheng W Tags: Chemosphere Source Type: research