American Journal of Clinical Pathology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.p53 immunohistochemistry as an ancillary tool for rapid assessment of residual disease in TP53-mutated acute myeloid leukemia and myelodysplastic syndromes
CONCLUSIONS: Our study suggests that p53 IHC can be used as a rapid tool (within 24 hours) to aid in the detection of residual disease that may complement MRD-FC or NGS in cases in which the flow cytometry immunophenotype is equivocal and/or the bone marrow aspirate is suboptimal.PMID:38643353 | DOI:10.1093/ajcp/aqae034 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 21, 2024 Category: Pathology Authors: Nivaz Brar Lauren Lawrence Eula Fung James L Zehnder Peter L Greenberg Gabriel N Mannis Tian Y Zhang Dita Gratzinger Jean Oak Oscar Silva Jason Kurzer Brent Tan Joshua R Menke Sebastian Fernandez-Pol Source Type: research
Early identification of patients at risk for iron-deficiency anemia using deep learning techniques
CONCLUSIONS: Our results showcase the feasibility of employing deep learning techniques for early prediction of IDA in the outpatient setting based on sequences of laboratory data, offering a substantial lead time for clinical intervention.PMID:38642073 | DOI:10.1093/ajcp/aqae031 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 20, 2024 Category: Pathology Authors: Nelly Estefanie Garduno-Rapp Yee Seng Ng Jenny L Weon Sameh N Saleh Christoph U Lehmann Chenlu Tian Andrew Quinn Source Type: research
Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma
CONCLUSIONS: The detection of K17 in 10% or greater of PDAC cells identified patients with shortest survival. Among patients with low K17 PDACs, 5-FU-based treatment was more likely than gemcitabine-based therapies to extend survival.PMID:38642081 | DOI:10.1093/ajcp/aqae038 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 20, 2024 Category: Pathology Authors: Lyanne A Delgado-Coka Lucia Roa-Pe ña Sruthi Babu Michael Horowitz Emanuel F Petricoin Lynn M Matrisian Edik M Blais Natalia Marchenko Felicia D Allard Ali Akalin Wei Jiang Brent K Larson Andrew E Hendifar Vincent J Picozzi Minsig Choi Kenneth R Shroyer Source Type: research
Concentration of voxelotor in sickle cell disease can be estimated using electrophoresis and high-performance liquid chromatography
CONCLUSIONS: Thus, peak splitting CZE and HPLC can be used to estimate voxelotor concentration.PMID:38639326 | DOI:10.1093/ajcp/aqae042 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 19, 2024 Category: Pathology Authors: Susanna A Curtis Elana Friedman Caterina Minniti Annie Nguyen Dang Mira Pochron Merin Thomas Jaime Betancourt Leena Vattappally Andrew Crouch Julissa Morales Sean T Campbell Source Type: research
Auditing plasma transfusion in intensive care: Use of decision time interval analysis
CONCLUSIONS: Compared with traditional methods of displaying the results of blood audits, DTI analysis displays information regarding the decision both to transfuse and to not transfuse. Utilization reviews that display data based on decision time analysis reveal clinical practice patterns very different from those suggested by traditional displays of plasma audit data.PMID:38635300 | DOI:10.1093/ajcp/aqae041 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Walter H Dzik Kristen Ruby Patricia A R Brunker Julia Collins Hyun-Il Paik Robert Makar Source Type: research
Warm reactive autoantibodies detected by solid phase technology: Patient characteristics, laboratory features, and clinical significance
CONCLUSIONS: Warm reactive autoantibodies are more likely to be hemolytic, have strongly reactive indirect and direct antiglobulin tests, remain reactive in tube-based ancillary testing methods, and are seen primarily in patients with hematologic disorders.PMID:38637286 | DOI:10.1093/ajcp/aqae039 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Douglas P Blackall Jennifer T Little Source Type: research
Auditing plasma transfusion in intensive care: Use of decision time interval analysis
CONCLUSIONS: Compared with traditional methods of displaying the results of blood audits, DTI analysis displays information regarding the decision both to transfuse and to not transfuse. Utilization reviews that display data based on decision time analysis reveal clinical practice patterns very different from those suggested by traditional displays of plasma audit data.PMID:38635300 | DOI:10.1093/ajcp/aqae041 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Walter H Dzik Kristen Ruby Patricia A R Brunker Julia Collins Hyun-Il Paik Robert Makar Source Type: research
Comparative analysis of ChatGPT and Bard in answering pathology examination questions requiring image interpretation
CONCLUSIONS: This study demonstrated the potential of ChatGPT and Bard in pathology education, stressing the importance of clinical context for accurate AI interpretations of pathology images. It underlined the need for careful AI integration in medical education.PMID:38619043 | DOI:10.1093/ajcp/aqae036 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 15, 2024 Category: Pathology Authors: Sompon Apornvirat Chutimon Namboonlue Thiyaphat Laohawetwanit Source Type: research
Comparative analysis of ChatGPT and Bard in answering pathology examination questions requiring image interpretation
CONCLUSIONS: This study demonstrated the potential of ChatGPT and Bard in pathology education, stressing the importance of clinical context for accurate AI interpretations of pathology images. It underlined the need for careful AI integration in medical education.PMID:38619043 | DOI:10.1093/ajcp/aqae036 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 15, 2024 Category: Pathology Authors: Sompon Apornvirat Chutimon Namboonlue Thiyaphat Laohawetwanit Source Type: research
Comparative analysis of ChatGPT and Bard in answering pathology examination questions requiring image interpretation
CONCLUSIONS: This study demonstrated the potential of ChatGPT and Bard in pathology education, stressing the importance of clinical context for accurate AI interpretations of pathology images. It underlined the need for careful AI integration in medical education.PMID:38619043 | DOI:10.1093/ajcp/aqae036 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 15, 2024 Category: Pathology Authors: Sompon Apornvirat Chutimon Namboonlue Thiyaphat Laohawetwanit Source Type: research
Comparison of the solid-phase red cell adherence assay and tube method for detection and identification of red blood cell antibodies
CONCLUSIONS: To our knowledge, this is the first robust, 15-year study comparing methodologic sensitivity to detect clinically significant alloantibodies. The incidence of discordant results between PEG-IAT and the solid-phase technique was low. Among discordant samples, anti-Jka was commonly detected using the solid-phase method but not with the PEG-IAT. In contrast, anti-E was commonly detected by PEG-IAT but not by the solid-phase method.PMID:38607807 | DOI:10.1093/ajcp/aqae035 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 12, 2024 Category: Pathology Authors: Mohamed Abdelmonem Alex Dussaq Kathy Papakonstantino Muharrem Yunce Mrigender Singh Virk Source Type: research
Comparison of the solid-phase red cell adherence assay and tube method for detection and identification of red blood cell antibodies
CONCLUSIONS: To our knowledge, this is the first robust, 15-year study comparing methodologic sensitivity to detect clinically significant alloantibodies. The incidence of discordant results between PEG-IAT and the solid-phase technique was low. Among discordant samples, anti-Jka was commonly detected using the solid-phase method but not with the PEG-IAT. In contrast, anti-E was commonly detected by PEG-IAT but not by the solid-phase method.PMID:38607807 | DOI:10.1093/ajcp/aqae035 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 12, 2024 Category: Pathology Authors: Mohamed Abdelmonem Alex Dussaq Kathy Papakonstantino Muharrem Yunce Mrigender Singh Virk Source Type: research
Comparison of the solid-phase red cell adherence assay and tube method for detection and identification of red blood cell antibodies
CONCLUSIONS: To our knowledge, this is the first robust, 15-year study comparing methodologic sensitivity to detect clinically significant alloantibodies. The incidence of discordant results between PEG-IAT and the solid-phase technique was low. Among discordant samples, anti-Jka was commonly detected using the solid-phase method but not with the PEG-IAT. In contrast, anti-E was commonly detected by PEG-IAT but not by the solid-phase method.PMID:38607807 | DOI:10.1093/ajcp/aqae035 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 12, 2024 Category: Pathology Authors: Mohamed Abdelmonem Alex Dussaq Kathy Papakonstantino Muharrem Yunce Mrigender Singh Virk Source Type: research
Predictors of clinical outcome in myeloproliferative neoplasm, unclassifiable: A Bone Marrow Pathology Group study
CONCLUSIONS: This study, as one of the largest of MPN-U studies incorporating both clinicopathologic and molecular data, moves toward identification of biomarkers that better predict prognosis in this heterogeneous category.PMID:38597584 | DOI:10.1093/ajcp/aqae033 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 10, 2024 Category: Pathology Authors: Genevieve M Crane Julia T Geyer Beenu Thakral Sa A Wang Geoffrey D Wool Ke David Li Adam R Davis Leonardo Boiocchi David Bosler Carlos E Bueso-Ramos Daniel A Arber Tracy I George Adam Bagg Robert P Hasserjian Attilio Orazi Eric D Hsi Heesun J Rogers Source Type: research
Predictors of clinical outcome in myeloproliferative neoplasm, unclassifiable: A Bone Marrow Pathology Group study
CONCLUSIONS: This study, as one of the largest of MPN-U studies incorporating both clinicopathologic and molecular data, moves toward identification of biomarkers that better predict prognosis in this heterogeneous category.PMID:38597584 | DOI:10.1093/ajcp/aqae033 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 10, 2024 Category: Pathology Authors: Genevieve M Crane Julia T Geyer Beenu Thakral Sa A Wang Geoffrey D Wool Ke David Li Adam R Davis Leonardo Boiocchi David Bosler Carlos E Bueso-Ramos Daniel A Arber Tracy I George Adam Bagg Robert P Hasserjian Attilio Orazi Eric D Hsi Heesun J Rogers Source Type: research
