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S100A8 and S100A9 proteins are expressed by human corneal stromal dendritic cells
Conclusions A8 and A9 expression may distinguish between subpopulations of DC that reside in different regions of the human cornea and may influence their maturation status. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Wilkinson, A., Kawaguchi, N., Geczy, C., Di Girolamo, N. Tags: Original articles - Laboratory science Source Type: research

Clinical manifestations and outcome of tuberculous sclerokeratitis
Conclusions Antituberculous medications can lead to complete resolution of the sclerokeratitis without concomitant use of steroids, or other anti-inflammatory agents. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Shoughy, S. S., Jaroudi, M. O., Tabbara, K. F. Tags: Cornea, Ocular surface, Sclera and apisclera Original articles - Clinical science Source Type: research

Implications of enlarged infraorbital nerve in idiopathic orbital inflammatory disease
Conclusions Patients with ION-enlarged IOI showed distinct clinical and radiological characteristics. As IOI accompanied by ION enlargement showed significantly higher steroid dependency and recurrence rate, a more careful follow-up of patients during steroid tapering might be helpful to prevent recurrence of IOI. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Lee, K. H., Han, S. H., Yoon, J. S. Tags: Orbit, Neurology Original articles - Clinical science Source Type: research

Scleritis associated with relapsing polychondritis
Conclusions Scleritis may be the first manifestation whose study leads to the diagnosis of RP. Scleritis associated with RP is more often bilateral, necrotising, recurrent and associated with decrease of vision than scleritis associated with other SIMD. About 69.2% of patients will have an additional SIMD disorder. Scleritis associated with RP most often will require immunomodulatory therapy. Occasionally, scleritis with RP may appear while using antitumor necrosis factor α agents. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Sainz-de-la-Maza, M., Molina, N., Gonzalez-Gonzalez, L. A., Doctor, P. P., Tauber, J., Foster, C. S. Tags: Angle, Choroid, Cornea, Intraocular pressure, Ocular surface, Sclera and apisclera, Vision, Neurology Original articles - Clinical science Source Type: research

Clinical features, microbiological profiles and treatment outcome of lacrimal plug-related canaliculitis compared with those of primary canaliculitis
Conclusions In comparison with primary canaliculitis, plug-related canaliculitis appear to be more prevalent in women and show a different microbiological profile. Retrieval of infected plug by canaliculotomy and adequate antibiotics can achieve a good outcome. Long-term follow-up is required because canaliculitis may develop several years after plug insertion. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Huang, Y.-Y., Yu, W.-K., Tsai, C.-C., Kao, S.-C., Kau, H.-C., Liu, C. J.-L. Tags: Original articles - Clinical science Source Type: research

Enlargement of the superior rectus and superior oblique muscles causes intorsion in Graves eye disease
Conclusions Preoperative SR and/or SO muscle enlargement appear to be a primary contributing factor relating to preoperative and postoperative intorsion in patients with GED-associated strabismus. Patients with only small amounts of preoperative extorsion (<3.5°) in the presence of tight IRs should be carefully evaluated for possible SR and/or SO involvement by CT or MRI scan to predict those at risk for and plan for prevention/treatment of postoperative intorsion. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Wei, Y., Kang, X. l., Del Monte, M. A. Tags: Muscles, Neurology Original articles - Clinical science Source Type: research

Association between light-to-dark changes in angle width and iris parameters in light, dark and changes from light-to-dark conditions
Conclusions Evaluation of iris parameters in light, dark and changes from light-to-dark conditions demonstrated that IT750, IT2000, IArea and PD in light conditions are significant predictors of light-to-dark changes in angle width. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Lee, R. Y., Lin, S.-C., Chen, R. I., Barbosa, D. T., Lin, S. C. Tags: Epidemiology Original articles - Clinical science Source Type: research

Comparison of trabeculectomy versus Ex-PRESS: 3-year follow-up
Conclusions We found no difference in success rates, mean IOP or other secondary outcomes between Ex-PRESS and trabeculectomy after 3 years of follow-up. Trial registration number NCT01263561; post results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Gonzalez-Rodriguez, J. M., Trope, G. E., Drori-Wagschal, L., Jinapriya, D., Buys, Y. M. Tags: Ophthalmologic surgical procedures, Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Monitoring ocular hypertension, how much and how often? A cost-effectiveness perspective
Conclusions For confirmed OHT, glaucoma monitoring more frequently than every 2 years is unlikely to be efficient. Primary treatment and minimal monitoring (assessing treatment responsiveness (IOP)) could be considered; however, further data to refine glaucoma risk prediction models and value patient preferences for treatment are needed. Consideration to innovative and affordable service redesign focused on treatment responsiveness rather than more glaucoma testing is recommended. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Hernandez, R., Burr, J., Vale, L., Azuara-Blanco, A., Cook, J., Banister, K., Tuulonen, A., Ryan, M., for the Surveillance of Ocular Hypertension Study group, Botello-Pinzon, Takwoingi, Vazquez-Montes, Elders, Asaoka, van der Schoot, Fraser, King, Lemij, Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Microcatheter-assisted trabeculotomy versus rigid probe trabeculotomy in childhood glaucoma
Conclusion Microcatheter-assisted circumferential trabeculotomy is a more effective treatment and is as safe as traditional trabeculotomy with a rigid probe for primary congenital glaucoma in the early postoperative course. Trial registration number ChiCTR-OCC-15005789, Results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Shi, Y., Wang, H., Yin, J., Li, M., Zhang, X., Xin, C., Chen, X., Wang, N. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

The height of the posterior staphyloma and corneal hysteresis is associated with the scleral thickness at the staphyloma region in highly myopic normal-tension glaucoma eyes
Conclusion Subfoveal scleral thinning and non-uniform posterior staphyloma were closely related in highly myopic NTG eyes. Corneal hysteresis, corneal resistance factor and the nasal posterior staphyloma height were associated with the scleral thickness. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Park, J. H., Choi, K.-R., Kim, C. Y., Kim, S. S. Tags: Angle, Intraocular pressure, Optic nerve, Glaucoma, Optics and refraction Original articles - Clinical science Source Type: research

Perceptual visual dysfunction, physical impairment and quality of life in Bangladeshi children with cerebral palsy
Conclusions PVD is an important contributor in reducing quality of life in children with CP, independent of motor disability and acuity impairment. Better characterisation of PVD is important to help design interventions for affected children, which may improve their quality of life. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Mitry, D., Williams, C., Northstone, K., Akter, A., Jewel, J., Khan, N., Muhit, M., Gilbert, C. E., Bowman, R. Tags: Paediatrics, Neurology Original articles - Clinical science Source Type: research

Correlation of central visual function and ROP risk factors in prematures with and without acute ROP at the age of 6-13 years: the Giessen long-term ROP study
Conclusions Low BW, GA and increasing severity of spontaneously resolving ROP were associated with significantly decreased central visual function. In addition to VA, LIS measurement further describes foveal function and is a unique parameter to assess parafoveal function. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Bowl, W., Lorenz, B., Stieger, K., Schweinfurth, S., Holve, K., Friedburg, C., Andrassi-Darida, M. Tags: Paediatrics, Retina, Editor's choice, Epidemiology Original articles - Clinical science Source Type: research

Macular nerve fibre and ganglion cell layer changes in acute Leber's hereditary optic neuropathy
Conclusions The natural history of GC-IPL thinning follows a specific pattern of reduction, reflecting the anatomical course of papillomacular fibres. Month 6 represents the end of GC-IPL loss. GC-IPL and mRNFL thinning is detectable before onset of visual loss. These observations can help future therapeutic approaches for both LHON carriers at high risk of conversion and patients with acute early LHON. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Balducci, N., Savini, G., Cascavilla, M. L., La Morgia, C., Triolo, G., Giglio, R., Carbonelli, M., Parisi, V., Sadun, A. A., Bandello, F., Carelli, V., Barboni, P. Tags: Optic nerve, Neurology Original articles - Clinical science Source Type: research

The extent of stretched lamellar cleavage and visual acuity in macular pseudoholes
Conclusions Although advanced cleavage in macular pseudohole is associated with worse VA before surgery, even an advanced pseudohole could show favourable visual recovery after surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Toyama, T., Roggia, M. F., Yamaguchi, T., Noda, Y., Ueta, T. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Phase IIb clinical trial of ranibizumab for the treatment of uveitic and idiopathic choroidal neovascular membranes
Conclusion Patients gained vision (mean of 21 letters at 12 months) and showed reduced CST. These results support the continued use of ranibizumab in the treatment of iCNV. Trial registration number 2008-007476-19, results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Carreno, E., Moutray, T., Fotis, K., Lee, R. W. J., Dick, A. D., Ross, A. H., Bailey, C. Tags: Original articles - Clinical science Source Type: research

Epidemiology and clinical characteristics of rhegmatogenous retinal detachment in Taiwan
Conclusions The annual incidence of RRD in Taiwan is comparable to most Western countries, with a relatively younger mean age. The male patients were more susceptible to retinal detachment in almost all age groups. Retinal detachment in patients with high myopia was associated with a younger age at onset. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Chen, S.-N., Lian, I.-B., Wei, Y.-J. Tags: Ophthalmologic surgical procedures, Lens and zonules, Optic nerve, Retina, Optics and refraction, Epidemiology Original articles - Clinical science Source Type: research

Vitrectomy After ocriplasmin for VitreOmacular adhesion Or Macular hole (VAVOOM) study
Conclusions Eyes with persistent symptomatic VMT and/or MH have similarly high rates of pathology resolution as well as similar VA gains regardless of whether they received ocriplasmin prior to PPV. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Greven, M. A., Garg, S., Chiu, B., Shah, S. P., Wolfe, J., Fine, H. F., Roth, D. B., Robinson, J., Mong, J., Hsu, J., Regillo, C., Ho, A., Haller, J. A. Tags: Ophthalmologic surgical procedures, Retina Original articles - Clinical science Source Type: research

Incidence and factors associated with complications of sutured and sutureless cataract surgery following pars plana vitrectomy at a tertiary referral centre in Turkey
Conclusions Longer duration of PPV surgery, a longer interval from PPV to silicone oil extraction, prior 20-gauge PPV, and 20-gauge PPV with scleral buckling surgery seem to influence the safety and outcomes of cataract surgery. Sutureless phacoemulsification in vitrectomised eyes was not associated with a higher incidence of endophthalmitis, suprachoroidal effusion or haemorrhage. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Hocaoglu, M., Karacorlu, M., Sayman Muslubas, I., Ozdemir, H., Arf, S., Uysal, O. Tags: Ophthalmologic surgical procedures, Choroid, Eye (globe), Lens and zonules Original articles - Clinical science Source Type: research

Evaluation and comparison of the new swept source OCT-based IOLMaster 700 with the IOLMaster 500
Conclusions Although the agreement between the two devices was excellent, the IOLMaster 700 was more effective in obtaining biometric measurements in eyes with posterior subcapsular and dense nuclear cataracts. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Akman, A., Asena, L., Güngör, S. G. Tags: Lens and zonules, Open access, Epidemiology Original articles - Clinical science Source Type: research

Corneal powers measured with a rotating Scheimpflug camera
Conclusions Pentacam rotating camera assessment of total corneal power over the central 3.0 mm zone differed significantly for simulated keratometry, equivalent power and Snell's law ray tracing. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Naeser, K., Savini, G., Bregnhoj, J. F. Tags: Original articles - Clinical science Source Type: research

Five-year results of Small Incision Lenticule Extraction (ReLEx SMILE)
Conclusions This first long-term study demonstrates SMILE to be an effective, stable and safe procedure for treatment of myopia and myopic astigmatism. Clinical trial number DE/CA93/KP/07/001. Post-results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Blum, M., Täubig, K., Gruhn, C., Sekundo, W., Kunert, K. S. Tags: Lens and zonules, Optic nerve, Optics and refraction Original articles - Clinical science Source Type: research

Evaluation of point-of-care test for elevated tear matrix metalloproteinase 9 in post-LASIK dry eyes
Conclusions Only half of post-LASIK dry eyes were found to have significant inflammation associated with elevated MMP-9. The OSDI is useful to non-specifically identify patients with symptomatic dry eye while the InflammaDry determined which patients with dry eye were associated with significant inflammation that may guide therapeutic management decisions. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Chan, T. C. Y., Ye, C., Chan, K. P., Chu, K. O., Jhanji, V. Tags: Ophthalmologic surgical procedures Original articles - Clinical science Source Type: research

Differential precision of corneal Pentacam HR measurements in early and advanced keratoconus
Conclusions Keratometric measurements on Pentacam HR are less reproducible in advanced keratoconus than in early keratoconus. In patients of Pentacam-derived Krumeich stage 1 or 2, an increase in K1, K2 or Kmax of more than 1 dioptre is likely to represent the real change in the corneal shape. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Flynn, T. H., Sharma, D. P., Bunce, C., Wilkins, M. R. Tags: Cornea, Ocular surface Original articles - Clinical science Source Type: research

Aetiology-specific comparison of long-term outcome of deep anterior lamellar keratoplasty for corneal diseases
Conclusions DALK provides good visual acuity with slight ECD decrease over long term in all groups. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Ogawa, A., Yamaguchi, T., Mitamura, H., Tomida, D., Shimazaki-Den, S., Murat, D., Satake, Y., Shimazaki, J. Tags: Ophthalmologic surgical procedures, Cornea, Eye (globe), Ocular surface Original articles - Clinical science Source Type: research

Prosthetic replacement of the ocular surface ecosystem: impact at 5 years
Conclusions PROSE treatment offers continued benefit, as defined by improved visual function and continued device wear at 5 years, in patients with complex corneal disease. Patients with distorted cornea have a higher rate of continued wear at 5 years than patients with OSD, although this is not true among all subgroups within OSD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Agranat, J. S., Kitos, N. R., Jacobs, D. S. Tags: Cornea, Ocular surface, Open access Original articles - Clinical science Source Type: research

Established and emerging ancillary techniques in management of microbial keratitis: a review
Microbial keratitis is a sight-threatening condition and an ocular emergency, because of the potential for rapid progression. Intensive topical antimicrobials are the mainstay and the gold standard of treatment for microbial keratitis. However, despite appropriate diagnosis and therapy, treatment failure is still common, and can result in significant morbidity due to corneal perforation and/or scarring. For this reason, clinicians continue to seek novel treatment techniques in order to expand the armamentarium of tools available to manage microbial keratitis, and in doing so improve clinical outcomes. In this review, we ex...
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Robaei, D., Carnt, N., Watson, S. Tags: Cornea, Ocular surface, Epidemiology Review Source Type: research

Blindness, cataract surgery and mortality in Ethiopia
Conclusions In this population, mortality risk was significantly elevated for older cataract-blind patients when compared with non-cataract-blind patients—an elevation of risk that was not noted in an age-matched cohort of cataract-blind patients who underwent cataract surgery as early as 1-year follow-up. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Thomas, B. J., Sanders, D. S., Oliva, M. S., Orrs, M. S., Glick, P., Ruit, S., Chen, W., Luoto, J., Tasfaw, A. K., Tabin, G. C. Tags: Lens and zonules, Vision, Neurology, Epidemiology Global issues Source Type: research

Highlights from this issue
Agranat et al (see page 1171) Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) Treatment results in a significant, sustained increase in visual functioning at five years in patients with complex corneal disease. Yamaguchi et al (see page 1176) The long-term visual outcome of deep anterior lamellar keratoplasty is not influenced by differences in aetiology, and hence its effectiveness does not vary in different corneal disorders including keratoconus, herpetic keratitis, stromal scar and corneal dystrophy. Flynn et al (see page 1183) In early keratoconus, inter-observer variation in keratometry on Pentacam HR ...
Source: British Journal of Ophthalmology - August 17, 2016 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

Delivery of macromolecules into the endothelium of whole ex vivo human cornea by femtosecond laser-activated carbon nanoparticles
Conclusions This study shows that a macromolecule can be delivered specifically into ECs of a whole organ-cultured human cornea, using fsL-activated CNPs. The delivery rate was relatively high for a non-viral method. Further optimisation is required to understand and reduce variability in cell mortality. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Jumelle, C., Mauclair, C., Houzet, J., Bernard, A., He, Z., Forest, F., Perrache, C., Gain, P., Thuret, G. Tags: Epidemiology Original articles - Laboratory science Source Type: research

Surgical management of temple-related problems following lateral wall rim-sparing orbital decompression for thyroid-related orbitopathy
Conclusions This is the first paper to show that persistent, troublesome temple-related problems following LWRS orbital decompression can be surgically corrected. Patients should be counselled about the potential risk of these complications when considering LWRS orbital decompression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Siah, W. F., Patel, B. C., Malhotra, R. Tags: Cornea, Muscles, Ocular surface, Orbit, Vision, Neurology Original articles - Clinical science Source Type: research

Evaluation of a new rebound tonometer for self-measurement of intraocular pressure
Conclusions Icare Home tonometry can be used for self-measurement by a majority of trained subjects. IOP measurements obtained using Icare Home tonometry by self-assessment and third party-assessment showed slight underestimation compared with GAT. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Dabasia, P. L., Lawrenson, J. G., Murdoch, I. E. Tags: Original articles - Clinical science Source Type: research

Neuroretinal rim area and ocular haemodynamic parameters in patients with normal-tension glaucoma with differing intracranial pressures
Conclusions Patients with NTG having lower ICP have decreased neuroretinal rim area and OA blood flow parameters compared with patients having higher ICP. Further longitudinal studies are needed to analyse the involvement of ICP in NTG management. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Siaudvytyte, L., Januleviciene, I., Daveckaite, A., Ragauskas, A., Siesky, B., Harris, A. Tags: Angle, Intraocular pressure, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Anxiety in visual field testing
Conclusions HVF testing induces more anxiety than HRT. Increased pretest anxiety may reduce HVF test reliability. Increased test experience or interventions aimed at reducing pretest anxiety may result in improved test reliability and accuracy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Chew, S. S. L., Kerr, N. M., Wong, A. B. C., Craig, J. P., Chou, C.-Y., Danesh-Meyer, H. V. Tags: Angle, Intraocular pressure, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Cycloplegic autorefraction versus subjective refraction: the Tehran Eye Study
Conclusions The cycloplegic refraction is more sensitive than the subjective one to measure refractive error at all age groups especially in children and young adults. The cyclorefraction technique is highly recommended to exactly measure the refractive error in momentous conditions such as refractive surgery, epidemiological researches and amblyopia therapy, especially in hypermetropic eyes and paediatric cases. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Hashemi, H., Khabazkhoob, M., Asharlous, A., Soroush, S., Yekta, A., Dadbin, N., Fotouhi, A. Tags: Paediatrics, Optic nerve, Vision, Neurology, Optics and refraction, Epidemiology Original articles - Clinical science Source Type: research

Assessing visual function in children with complex disabilities: the Bradford visual function box
Conclusions The results of this clinical study show that the BVFB is a reliable tool for assessing the visual function in children with severe learning disability in whom other tests fail to elicit a response. The need for a tool which is quick to administer and portable has previously been highlighted. The BVFB offers an option for children for whom other formal tests are unsuccessful in eliciting a response. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Pilling, R. F., Outhwaite, L., Bruce, A. Tags: Paediatrics, Neurology Original articles - Clinical science Source Type: research

Influence of progressive addition lenses on reading posture in myopic children
Conclusions The lens type and the near phoria state affected near vision posture. During reading, myopic esophoric children used a lower portion of their PALs compared with exophoric children, resulting in greater addition power. These results may partially explain why myopic children with near esophoria exhibited superior treatment effects in myopia control trials using PALs. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Bao, J., Wang, Y., Zhuo, Z., Yang, X., Tan, R., Drobe, B., Chen, H. Tags: Muscles, Optic nerve, Open access, Neurology, Optics and refraction Original articles - Clinical science Source Type: research

Vision screening in children: a retrospective study of social and demographic factors with regards to visual outcomes
Conclusions We found that children from the most deprived backgrounds and those from unstable homes were more likely to fail preschool vision screening. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: O'Colmain, U., Low, L., Gilmour, C., MacEwen, C. J. Tags: Public health, Vision, Open access, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Successful management of severe unilateral chemical burns in children using simple limbal epithelial transplantation (SLET)
Conclusions SLET appears to be a promising technique for treatment of LSCD secondary to ocular surface burns in children. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Mittal, V., Jain, R., Mittal, R., Vashist, U., Narang, P. Tags: Paediatrics Original articles - Clinical science Source Type: research

Iritis, glaucoma and corneal decompensation associated with BrightOcular cosmetic iris implant
Conclusions Cosmetic iris implants carry the risk of ocular damage when implanted in the anterior chamber of normal phakic eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Mansour, A. M., Ahmed, I. I. K., Eadie, B., Chelala, E., Saade, J. S., Slade, S. G., Mearza, A. A., Parmar, D., Ghabra, M., Luk, S., Kelly, A., Kaufman, S. C. Tags: Angle, Choroid, Eye (globe), Intraocular pressure, Iris, Editor's choice, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

Long-term visual acuity, retention and complications observed with the type-I and type-II Boston keratoprostheses in an Irish population
Conclusions These data demonstrate excellent visual acuity and retention outcomes in a cohort with a long follow-up period in a single centre. Complications remain a considerable source of morbidity. These outcomes provide further evidence for the long-term stability of type-I and type-II Boston keratoprostheses in the management of patients in whom a traditional graft is likely to fail. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Duignan, E. S., Ni Dhubhghaill, S., Malone, C., Power, W. Tags: Angle, Choroid, Eye (globe), Intraocular pressure, Retina, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

The efficacy of lens removal plus IOL implantation for the treatment of spherophakia with secondary glaucoma
Conclusions Both phacoemulsification+CTR+IOL and lensectomy with scleral-fixated PC IOL implantation are effective in lowering the IOP and enhancing the visual acuity in patients with spherophakia and secondary glaucoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Yang, J., Fan, Q., Chen, J., Wang, A., Cai, L., Sheng, H., Lu, W., Jiang, Y., Lu, Y. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Spontaneous rupture of the lens capsule in hypermature cataract: presentations and outcomes
Conclusion Spontaneous lens capsule rupture can occur in hypermature senile cataract (HMSC) and result in anterior or posterior dislocation of the nucleus or spontaneous resorption with or without an accompanying inflammatory reaction of varying severity. An acceptable visual outcome can be obtained, except in the presence of associated glaucoma or corneal decompensation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Goel, N., Nagar, M. Tags: Angle, Cornea, Intraocular pressure, Lens and zonules, Ocular surface, Glaucoma Original articles - Clinical science Source Type: research

Early versus delayed intravitreal betamethasone as an adjuvant in the treatment of presumed postoperative endophthalmitis: a randomised trial
Conclusions Early intravitreal betamethasone had no clear advantage versus delayed injection in the management of presumed postoperative endophthalmitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Koehrer, P., Bron, A. M., Chiquet, C., Thuret, G., Delbosc, B., Berrod, J.-P., Bourcier, T., Sauer, A., Jonval, L., D'Athis, P., Creuzot-Garcher, C. Tags: Ophthalmologic surgical procedures, Choroid, Eye (globe), Retina Original articles - Clinical science Source Type: research

Mycophenolate sodium for the treatment of chronic non-infectious uveitis of childhood
Conclusion Our data suggest that MPS is useful and well tolerated in children with chronic uveitis. MPS seems to be an effective drug for the treatment of chronic non-infectious uveitis of childhood and may be preferred as a first-line steroid-sparing agent in this form of uveitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Doycheva, D., Zierhut, M., Blumenstock, G., Sobolewska, B., Voykov, B., Hohmann, J., Spitzer, M. S., Deuter, C. Tags: Choroid, Ciliary body Original articles - Clinical science Source Type: research

Efficacy and safety of immunosuppressive agents in the treatment of necrotising scleritis: a retrospective, multicentre study in Korea
Conclusion The efficacy of cyclophosphamide in the treatment of necrotising scleritis was comparable with that of other ISAs. However, the rate of discontinuation due to side effects was much higher in the CYC group. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Jeon, H. S., Hyon, J. Y., Kim, M. K., Chung, T.-Y., Yoon, K. C., Kim, J. Y., Na, K.-S., Kim, H. J., Kim, T.-I., Lee, J. S., Lee, H. K., Song, J. S. Tags: Sclera and apisclera Original articles - Clinical science Source Type: research

Scleritis in patients with granulomatosis with polyangiitis (Wegener)
Conclusions The presence of necrotising changes or corneal involvement in the setting of scleral inflammation is highly suggestive of an underlying systemic vasculitis, of which GPA is the most common. These features should alert the doctor/optometrist and prompt a thorough diagnostic approach and an aggressive treatment given that it could reveal a life-threatening disease. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Cocho, L., Gonzalez-Gonzalez, L. A., Molina-Prat, N., Doctor, P., Sainz-de-la-Maza, M., Foster, C. S. Tags: Angle, Choroid, Intraocular pressure, Sclera and apisclera, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Incidence and clinical features of post-injection endophthalmitis according to diagnosis
Conclusions Endophthalmitis rates appear to be lower in eyes with RVO compared with diabetic eye disease and neovascular AMD, possibly due to impaired immunity in diabetics and waning immunity in the generally older AMD population. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Rayess, N., Rahimy, E., Shah, C. P., Wolfe, J. D., Chen, E., DeCroos, F. C., Storey, P., Garg, S. J., Hsu, J. Tags: Choroid, Eye (globe), Retina, Epidemiology Original articles - Clinical science Source Type: research

Predicting vision gains with anti-VEGF therapy in neovascular age-related macular degeneration patients by using low-luminance vision
Conclusions The baseline BCVA–LLVA gap is a significant predictor of visual acuity response to anti-VEGF treatment in patients with wAMD. Trial registration number NCT00891735; Post-results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Frenkel, R. E. P., Shapiro, H., Stoilov, I. Tags: Retina, Open access Original articles - Clinical science Source Type: research

Extramacular drusen are highly associated with age-related macular degeneration, but not with CFH and ARMS2 genotypes
Conclusions The strong association between drusen within and outside of the macula suggests a common pathogenesis. However, EMD were not AMD-independently associated with CFH or ARMS2 genotypes. Our results indicate that patients without AMD but with EMD can serve as controls in studies evaluating AMD risk factors. Further studies are required to elucidate the aetiology and clinical relevance of EMD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - July 21, 2016 Category: Opthalmology Authors: Ersoy, L., Schick, T., de Graft, D., Felsch, M., Hoyng, C., den Hollander, A., Kirchhof, B., Fauser, S., Liakopoulos, S. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research