Mechanistic correlation of molecular pathways in obesity-mediated stroke pathogenesis
Pharmacol Rep. 2024 Apr 18. doi: 10.1007/s43440-024-00590-9. Online ahead of print.ABSTRACTObesity, a prominent risk factor for the development of heart attacks and several cardiovascular ailments. Obesity ranks as the second most significant avoidable contributor to mortality, whereas stroke stands as the second leading cause of death on a global scale. While changes in lifestyle have been demonstrated to have significant impacts on weight management, the long-term weight loss remains challenging, and the global prevalence of obesity continues to rise. The pathophysiology of obesity has been extensively studied during the...
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Heena Khan Chanchal Tiwari Palak Kalra Daksha Vyas Amarjot Kaur Grewal Thakur Gurjeet Singh Source Type: research
Pharmacokinetic interaction between regorafenib and atorvastatin in rats
CONCLUSIONS: This animal model study showed a significant pharmacokinetic interaction between regorafenib and atorvastatin. While this interaction may be clinically significant, this needs to be confirmed in clinical trials involving cancer patients.PMID:38632186 | DOI:10.1007/s43440-024-00570-z (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Danuta Szkutnik-Fiedler Edyta Sza łek Filip Otto Andrzej Czyrski Marta Kara źniewicz-Łada Anna Wolc Edmund Grze śkowiak Konrad Lewandowski Agnieszka Karbownik Source Type: research
Partial mGlu < sub > 5 < /sub > receptor NAM, M-5MPEP, induces rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhances (R)-ketamine action in mice
CONCLUSION: Partial mGlu5 receptor NAM, M-5MPEP, induced rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhanced (R)-ketamine action in mice, indicating both substances' convergent mechanisms of action and the possibility of their practical use in treating depression as RAAD.PMID:38632187 | DOI:10.1007/s43440-024-00588-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Agnieszka Pa łucha-Poniewiera Anna Rafa ło-Ulińska Michal Santocki Yana Babii Katarzyna Kaczorowska Source Type: research
Mechanistic correlation of molecular pathways in obesity-mediated stroke pathogenesis
Pharmacol Rep. 2024 Apr 18. doi: 10.1007/s43440-024-00590-9. Online ahead of print.ABSTRACTObesity, a prominent risk factor for the development of heart attacks and several cardiovascular ailments. Obesity ranks as the second most significant avoidable contributor to mortality, whereas stroke stands as the second leading cause of death on a global scale. While changes in lifestyle have been demonstrated to have significant impacts on weight management, the long-term weight loss remains challenging, and the global prevalence of obesity continues to rise. The pathophysiology of obesity has been extensively studied during the...
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Heena Khan Chanchal Tiwari Palak Kalra Daksha Vyas Amarjot Kaur Grewal Thakur Gurjeet Singh Source Type: research
Pharmacokinetic interaction between regorafenib and atorvastatin in rats
CONCLUSIONS: This animal model study showed a significant pharmacokinetic interaction between regorafenib and atorvastatin. While this interaction may be clinically significant, this needs to be confirmed in clinical trials involving cancer patients.PMID:38632186 | DOI:10.1007/s43440-024-00570-z (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Danuta Szkutnik-Fiedler Edyta Sza łek Filip Otto Andrzej Czyrski Marta Kara źniewicz-Łada Anna Wolc Edmund Grze śkowiak Konrad Lewandowski Agnieszka Karbownik Source Type: research
Partial mGlu < sub > 5 < /sub > receptor NAM, M-5MPEP, induces rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhances (R)-ketamine action in mice
CONCLUSION: Partial mGlu5 receptor NAM, M-5MPEP, induced rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhanced (R)-ketamine action in mice, indicating both substances' convergent mechanisms of action and the possibility of their practical use in treating depression as RAAD.PMID:38632187 | DOI:10.1007/s43440-024-00588-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Agnieszka Pa łucha-Poniewiera Anna Rafa ło-Ulińska Michal Santocki Yana Babii Katarzyna Kaczorowska Source Type: research
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia
CONCLUSION: The pharmacological properties of AMIO concerning healthy rat atrial tissue are not dependent on pHe. However, the prevention of arrhythmias induced by INa-Late is pHe-dependent. The development of drugs analogous to AMIO with charge stabilization may help to create more effective drugs to treat arrhythmias related to the INa-Late.PMID:38619735 | DOI:10.1007/s43440-024-00597-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 15, 2024 Category: Drugs & Pharmacology Authors: Michael Ramon de Lima Concei ção Jorge Lucas Teixeira-Fonseca Leisiane Pereira Marques Diego Santos Souza Fabiana da Silva Alc ântara Diego Jose Belato Orts Danilo Roman-Campos Source Type: research
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia
CONCLUSION: The pharmacological properties of AMIO concerning healthy rat atrial tissue are not dependent on pHe. However, the prevention of arrhythmias induced by INa-Late is pHe-dependent. The development of drugs analogous to AMIO with charge stabilization may help to create more effective drugs to treat arrhythmias related to the INa-Late.PMID:38619735 | DOI:10.1007/s43440-024-00597-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 15, 2024 Category: Drugs & Pharmacology Authors: Michael Ramon de Lima Concei ção Jorge Lucas Teixeira-Fonseca Leisiane Pereira Marques Diego Santos Souza Fabiana da Silva Alc ântara Diego Jose Belato Orts Danilo Roman-Campos Source Type: research
Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms
Pharmacol Rep. 2024 Apr 12. doi: 10.1007/s43440-024-00593-6. Online ahead of print.ABSTRACTOral diseases, including periodontal disorders, oral cancer, periodontitis, and mucositis are the major challenges for both patients and healthcare providers. These conditions often involve inflammation, oxidative stress, and impaired cellular processes, leading to symptoms ranging from discomfort to severe debilitation. Conventional treatments for such oral diseases exhibit constraints, prompting the investigation of innovative therapeutic approaches. Considering the anti-inflammatory, anti-oxidant, and anti-cancer effects of melato...
Source: Pharmacological Reports - April 12, 2024 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Ali Jamshidi Naeini Mohammad Sheibani Babak Gholamine Russel J Reiter Saeed Mehrzadi Source Type: research
Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms
Pharmacol Rep. 2024 Apr 12. doi: 10.1007/s43440-024-00593-6. Online ahead of print.ABSTRACTOral diseases, including periodontal disorders, oral cancer, periodontitis, and mucositis are the major challenges for both patients and healthcare providers. These conditions often involve inflammation, oxidative stress, and impaired cellular processes, leading to symptoms ranging from discomfort to severe debilitation. Conventional treatments for such oral diseases exhibit constraints, prompting the investigation of innovative therapeutic approaches. Considering the anti-inflammatory, anti-oxidant, and anti-cancer effects of melato...
Source: Pharmacological Reports - April 12, 2024 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Ali Jamshidi Naeini Mohammad Sheibani Babak Gholamine Russel J Reiter Saeed Mehrzadi Source Type: research
Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms
Pharmacol Rep. 2024 Apr 12. doi: 10.1007/s43440-024-00593-6. Online ahead of print.ABSTRACTOral diseases, including periodontal disorders, oral cancer, periodontitis, and mucositis are the major challenges for both patients and healthcare providers. These conditions often involve inflammation, oxidative stress, and impaired cellular processes, leading to symptoms ranging from discomfort to severe debilitation. Conventional treatments for such oral diseases exhibit constraints, prompting the investigation of innovative therapeutic approaches. Considering the anti-inflammatory, anti-oxidant, and anti-cancer effects of melato...
Source: Pharmacological Reports - April 12, 2024 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Ali Jamshidi Naeini Mohammad Sheibani Babak Gholamine Russel J Reiter Saeed Mehrzadi Source Type: research
Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms
Pharmacol Rep. 2024 Apr 12. doi: 10.1007/s43440-024-00593-6. Online ahead of print.ABSTRACTOral diseases, including periodontal disorders, oral cancer, periodontitis, and mucositis are the major challenges for both patients and healthcare providers. These conditions often involve inflammation, oxidative stress, and impaired cellular processes, leading to symptoms ranging from discomfort to severe debilitation. Conventional treatments for such oral diseases exhibit constraints, prompting the investigation of innovative therapeutic approaches. Considering the anti-inflammatory, anti-oxidant, and anti-cancer effects of melato...
Source: Pharmacological Reports - April 12, 2024 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Ali Jamshidi Naeini Mohammad Sheibani Babak Gholamine Russel J Reiter Saeed Mehrzadi Source Type: research
Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer
CONCLUSION: The Mediator kinase module is deregulated in a sub-set of colorectal cancers with differences observed in genomically defined groups. These variations may result in differences in sensitivity to targeted therapies and may have to be taken into consideration as such therapies are developed.PMID:38602606 | DOI:10.1007/s43440-024-00589-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 11, 2024 Category: Drugs & Pharmacology Authors: Ioannis A Voutsadakis Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
