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Effects of long-term administration of pantoprazole on bone mineral density in young male rats.
CONCLUSION: We observed that PPIs might have a negative impact on bone formation in growing rats mainly due to their inhibitory effects on the gastric proton pump, with probable deterioration of calcium absorption and decrease in growth plate thickness. PMID: 27552060 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 20, 2016 Category: Drugs & Pharmacology Authors: Matuszewska A, Nowak B, Rzeszutko M, Zduniak K, Szandruk M, Jędrzejuk D, Landwójtowicz M, Bolanowski M, Pieśniewska M, Kwiatkowska J, Szeląg A Tags: Pharmacol Rep Source Type: research

Resveratrol intake enhances indoleamine-2,3-dioxygenase activity in humans.
CONCLUSION: This is the first evidence of a modulatory effect of orally administered resveratrol on tryptophan metabolism in humans. Since IDO has been shown to play a crucial role in immunity, cancer development and regulation of vascular tone, the modulation of this enzyme might be involved in resveratrol's diverse biological effects. PMID: 27552061 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 20, 2016 Category: Drugs & Pharmacology Authors: Gualdoni GA, Fuchs D, Zlabinger GJ, Gostner JM Tags: Pharmacol Rep Source Type: research

Intravenous lidocaine infusions in a multidirectional model of treatment of neuropathic pain patients.
CONCLUSIONS: The best therapeutic effects of lidocaine infusion was observed in pain symptoms characterized by the highest intensity of baseline pain. Intravenous lidocaine administered at the dose of 5mg/kg of body weight over 30min is effective, safe and caused no significant adverse effects. PMID: 27552062 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 20, 2016 Category: Drugs & Pharmacology Authors: Przeklasa-Muszyńska A, Kocot-Kępska M, Dobrogowski J, Wiatr M, Mika J Tags: Pharmacol Rep Source Type: research

Combining hypobaric hypoxia or hyperbaric oxygen postconditioning with memantine reduces neuroprotection in 7-day-old rat hypoxia-ischemia.
CONCLUSIONS: Our results show that, combining HBO or HH postconditioning with memantine produce no additive increase in the neuroprotective effect. On the contrary, combining the treatments resulted in lower neuroprotection in comparison to the effects of memantine, HBO or HH alone. PMID: 27552063 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 20, 2016 Category: Drugs & Pharmacology Authors: Gamdzyk M, Ziembowicz A, Bratek E, Salinska E Tags: Pharmacol Rep Source Type: research

N-pentyl-nitrofurantoin induces apoptosis in HL-60 leukemia cell line by upregulating BAX and downregulating BCL-xL gene expression.
CONCLUSION: The results indicate that NFP induces apoptosis in HL-60 cells by upregulating BAX and downregulating BCL-xL. PMID: 27505854 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 6, 2016 Category: Drugs & Pharmacology Authors: Andrade JK, Souza MI, Gomes Filho MA, Silva DM, Barros AL, Rodrigues MD, Silva PB, Nascimento SC, Aguiar JS, Brondani DJ, Militão GC, Silva TG Tags: Pharmacol Rep Source Type: research

Puerarin inhibits the inflammatory response in atherosclerosis via modulation of the NF- κB pathway in a rabbit model.
CONCLUSIONS: This study indicates that the effect of puerarin on the suppression of atherosclerosis was connected with an inhibited inflammatory response and reduced NF-κB activation. PMID: 27505855 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 6, 2016 Category: Drugs & Pharmacology Authors: Ji L, Du Q, Li Y, Hu W Tags: Pharmacol Rep Source Type: research

Peripheral mRNA expression of pluripotency markers in bipolar disorder and the effect of long-term lithium treatment.
CONCLUSIONS: The overexpression of the pluripotency master transcriptional factors in patients with a long duration of BD not treated with lithium, may contribute to the pathogenesis of the illness and make them potential biological markers of BD. Long-term lithium treatment may attenuate these excessive regenerative processes, especially in relation to the transcription factors Oct-4 and Sox2. PMID: 27472467 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 26, 2016 Category: Drugs & Pharmacology Authors: Ferensztajn-Rochowiak E, Tarnowski M, Samochowiec J, Michalak M, Ratajczak MZ, Rybakowski JK Tags: Pharmacol Rep Source Type: research

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations.
Abstract Cardiac safety is an issue causing early terminations at various stages of drug development. Efforts are put into the elimination of false negatives as well as false positives resulting from the current testing paradigm. In silico approaches offer mathematical system and data description from the ion current, through cardiomyocytes level, up to incorporation of inter-individual variability at the population level. The article aims to review three main modelling and simulation approaches, i.e. "top-down" which refers to models built on the observed data, "bottom-up", which stands for a mechanistic descript...
Source: Pharmacological Reports - July 20, 2016 Category: Drugs & Pharmacology Authors: Tylutki Z, Polak S, Wiśniowska B Tags: Curr Pharmacol Rep Source Type: research

Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study.
CONCLUSION: We showed that the tested transplant drugs have no effect on the expression of selected phase II and antioxidant enzymes in human hepatocytes. Nevertheless, the experiments carried out in two common and frequently used in vitro cellular models, we emphasize that finding based solely on carcinoma cells must be taken with caution when transposing to in vivo situations. PMID: 27428762 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 15, 2016 Category: Drugs & Pharmacology Authors: Vrzal R, Illes P, Dvorak Z Tags: Pharmacol Rep Source Type: research

Coenzyme Q10 - A new player in the treatment of heart failure?
Abstract Coenzyme Q10 is the only endogenously synthesized lipid with a redox function which exhibits broad tissue and intracellular distribution in mammals. Beneficial effects of CoenzymeQ10 supplementation were observed in several age-related diseases including heart failure. CoQ10 (coenzyme Q10) level is significantly decreased in patients with this disease, which correlates with severity of clinical symptoms. Supplementation with various pharmaceutical formulations of CoQ10 improves impaired cardiac function and clinical course of heart failure. Current data from clinical trials indicate that CoQ10 can signifi...
Source: Pharmacological Reports - July 15, 2016 Category: Drugs & Pharmacology Authors: Jankowski J, Korzeniowska K, Cieślewicz A, Jabłecka A Tags: Pharmacol Rep Source Type: research

Potential antidepressant-like activity of silymarin in the acute restraint stress in mice: Modulation of corticosterone and oxidative stress response in cerebral cortex and hippocampus.
CONCLUSION: The present experimental findings indicate that silymarin exhibits antidepressant like activity probably either through alleviating oxidative stress by modulation of corticosterone response, and antioxidant defense system in hippocampus and cerebral cortex in ARS mice. PMID: 27428764 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 15, 2016 Category: Drugs & Pharmacology Authors: Thakare VN, Dhakane VD, Patel BM Tags: Pharmacol Rep Source Type: research

Early antipsychotic exposure affects serotonin and dopamine receptor binding density differently in selected brain loci of male and female juvenile rats.
CONCLUSION: This study revealed that aripiprazole, olanzapine and risperidone affected 5-HT2AR, 5-HT2CR, 5-HTT, D1R and D2R bindings differently in the brains of juvenile male and female rats. PMID: 27428765 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 15, 2016 Category: Drugs & Pharmacology Authors: Lian J, Pan B, Deng C Tags: Pharmacol Rep Source Type: research

Antidepressant-like effects of ascorbic acid and ketamine involve modulation of GABAA and GABAB receptors.
CONCLUSIONS: Results indicate that the anti-immobility effect of ascorbic acid and ketamine in TST may involve an activation of GABAA receptors and a possible inhibition of GABAB receptors. PMID: 27423525 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 14, 2016 Category: Drugs & Pharmacology Authors: Rosa PB, Neis VB, Ribeiro CM, Moretti M, Rodrigues AL Tags: Pharmacol Rep Source Type: research

Everolimus treatment among patients with tuberous sclerosis affects serum lipid profile.
CONCLUSIONS: Patients with TSC have disrupted lipid homeostasis before and during treatment with everolimus, which might be partially connected to the mTOR-dependent nutritional status of the patients. There is a need to develop strategies for children with TSC treated with everolimus, who experience hyperlipidemia. PMID: 27423526 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 14, 2016 Category: Drugs & Pharmacology Authors: Trelińska J, Dachowska I, Kotulska K, Jóźwiak S, Fendler W, Młynarski W Tags: Pharmacol Rep Source Type: research

Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon.
CONCLUSIONS: Neuroleptic-induced reduction in the expression of thalamic NMDA-R subunits may play an important role in the regulation of glutamatergic transmission disorders in cortico-striato-thalamo-cortical loop in schizophrenia. A decrease in NMDA signaling in this region after long-term neuroleptic administration may also cautiously explain the incomplete effectiveness of these drugs in the therapy of schizophrenia-related cognitive disturbances. PMID: 27391358 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 5, 2016 Category: Drugs & Pharmacology Authors: Krzystanek M, Bogus K, Pałasz A, Wiaderkiewicz A, Filipczyk Ł, Rojczyk E, Worthington J, Wiaderkiewicz R Tags: Pharmacol Rep Source Type: research

Repositioning of anti-viral drugs as therapy for cervical cancer.
CONCLUSION: The study thus provides evidence that Ribavirin and Indinavir can be explored as therapy against HPV-18 induced cervical cancer. PMID: 27379616 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 2, 2016 Category: Drugs & Pharmacology Authors: Sharma S, Baksi R, Agarwal M Tags: Pharmacol Rep Source Type: research

Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse.
CONCLUSIONS: H2S inhibits the expression of BACE1 and PS1 by activating PI3K/Akt pathway in AD. PMID: 27372924 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 30, 2016 Category: Drugs & Pharmacology Authors: He XL, Yan N, Chen XS, Qi YW, Yan Y, Cai Z Tags: Pharmacol Rep Source Type: research

Clinical efficacy and safety of eperisone for low back pain: A systematic literature review.
Abstract Eperisone, an analgesic and centrally acting muscle relaxant has been in use for the treatment of low back pain (LBP). The present systematic review evaluates the efficacy and safety of eperisone in patients with LBP. Cochrane Back and Neck (CBN) Group and Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were adopted to perform this systematic review. For risk of bias assessment CBN Group and Moga tools were used. Seven (5 randomized controlled trials [RCTs] and 2 uncontrolled studies) studies involving 801 participants were included. Eperisone intervention may be eff...
Source: Pharmacological Reports - June 29, 2016 Category: Drugs & Pharmacology Authors: Bavage S, Durg S, Ali Kareem S, Dhadde SB Tags: Pharmacol Rep Source Type: research

Protective effects of MCR-1329, a dual α1 and angII receptor antagonist, in mineralocorticoid-induced hypertension.
CONCLUSIONS: MCR-1329 has the potential to be evaluated further for clinical development as a potential antihypertensive agent with multiple mechanisms of action. PMID: 27371897 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 29, 2016 Category: Drugs & Pharmacology Authors: Gandhi H, Naik P, Agrawal N, Yadav M Tags: Pharmacol Rep Source Type: research

Involvement of CGRP receptors in retinal spreading depression.
CONCLUSIONS: The data suggest that CGRP receptors mediate RSD propagation involving neuronal mechanism and approve that RSD is an efficient in vitro approach for assessing anti-migraine drugs targeting CGRP receptors. PMID: 27362770 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 27, 2016 Category: Drugs & Pharmacology Authors: Wang Y, Li Y, Wang M Tags: Pharmacol Rep Source Type: research

Resolvin D1 down-regulates CYP1A1 and PTGS2 gene in the HUVEC cells treated with benzo(a)pyrene.
CONCLUSIONS: Our data suggests that RvD1 can significantly contributes on vascular function and alleviates the harmful effects caused by BaP, which might potentially aid in the repair of the injured endothelium. PMID: 27362771 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 27, 2016 Category: Drugs & Pharmacology Authors: Gdula-Argasińska J, Czepiel J, Totoń-Żurańska J, Jurczyszyn A, Wołkow P, Librowski T, Perucki W Tags: Pharmacol Rep Source Type: research

Treatment with high dose of atorvastatin reduces vascular injury in diabetic rats.
CONCLUSIONS: The results suggest that treatment with high dose of atorvastatin, independent of glycemia, improves endothelial function in aortas from diabetic rats by reducing the constrictor prostanoids derived from COX-2 and by reducing the oxidative stress by NADPH oxidase, as well as a possible increasing of nitric oxide participation. PMID: 27351941 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 25, 2016 Category: Drugs & Pharmacology Authors: Simões FV, de Batista PR, Botelho T, Ribeiro-Júnior RF, Padilha AS, Vassallo DV Tags: Pharmacol Rep Source Type: research

Food, nutrients and nutraceuticals affecting the course of inflammatory bowel disease.
Abstract Inflammatory bowel diseases (ulcerative colitis; Crohn's disease) are debilitating relapsing inflammatory disorders affecting the gastrointestinal tract, with deleterious effect on quality of life, and increasing incidence and prevalence. Mucosal inflammation, due to altered microbiota, increased intestinal permeability and immune system dysfunction underlies the symptoms and may be caused in susceptible individuals by different factors (or a combination of them), including dietary habits and components. In this review we describe the influence of the Western diet, obesity, and different nutraceuticals/fu...
Source: Pharmacological Reports - June 3, 2016 Category: Drugs & Pharmacology Authors: Uranga JA, López-Miranda V, Lombó F, Abalo R Tags: Pharmacol Rep Source Type: research

Characteristics, diagnosis and therapeutic strategies for IgG4-related orbital disease.
Abstract Thanks to detailed studies conducted in recent years, a new disease syndrome was identified in 2001. It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs. Orbital IgG4-related disease is a recently reported issue that may prove important for the elucidation of the etiology of idiopathic, lymphoplasmacytic or fibrotic disorders of various organs, including the orbits. In this ar...
Source: Pharmacological Reports - April 29, 2016 Category: Drugs & Pharmacology Authors: Oles K, Sładzień J, Bartuś K, Leszczyńska J, Bojanowska E, Krakowczyk Ł, Mika J Tags: Pharmacol Rep Source Type: research

Natural terpenoids as a promising source for modulation of GABAergic system and treatment of neurological diseases.
Abstract γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter reducing neural excitability in the mammalian central nervous system (CNS) with three subclasses of receptors. Several conventional drugs and compounds modulate the GABAergic system, demonstrating different pharmacological effects. In this review, interactions of natural terpenoids with the GABAergic system are highlighted with relation to disorders like anxiety, insomnia, convulsion, pain, and cognitive deficits. Terpenoids with various structures affect the function of the GABAergic system via dissimilar mechanisms. Most of the discusse...
Source: Pharmacological Reports - April 8, 2016 Category: Drugs & Pharmacology Authors: Manayi A, Nabavi SM, Daglia M, Jafari S Tags: Pharmacol Rep Source Type: research

Therapeutic equivalence of antipsychotics and antidepressants - A systematic review.
Abstract The number of newly approved generic psychotropic drugs increases every year and, in many countries, their sales exceed the sales of brand-name counterparts. In order for any generic drug to receive an approval of regulatory authorities, its bioequivalence with the corresponding reference product must be demonstrated. Moreover, generic drugs must meet the same quality standards as reference drugs. However, many psychiatrists express concerns about use of generic drugs. We carried out a systematic analysis of the relevant literature indexed in PubMed and Cochrane databases. The MeSH term "generic" was comb...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Cessak G, Rokita K, Dąbrowska M, Rozbicka KS, Zaremba A, Mirowska-Guzel D, Bałkowiec-Iskra E Tags: Pharmacol Rep Source Type: research

The effect of lithium on hematopoietic, mesenchymal and neural stem cells.
Abstract Lithium has been used in modern psychiatry for more than 65 years, constituting a cornerstone for the long-term treatment of bipolar disorder. A number of biological properties of lithium have been discovered, including its hematological, antiviral and neuroprotective effects. In this article, a systematic review of the effect of lithium on hematopoietic, mesenchymal and neural stem cells is presented. The beneficial effects of lithium on the level of hematopoietic stem cells (HSC) and growth factors have been reported since 1970s. Lithium improves homing of stem cells, the ability to form colonies and HS...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Ferensztajn-Rochowiak E, Rybakowski JK Tags: Pharmacol Rep Source Type: research

Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs.
Abstract The pharmacological management of insomnia has lately become a challenge for researchers worldwide. As per the third International Classification of Sleep disorders (ICSD-3) insomnia can be defined as a state with repeated difficulty in sleep initiation, duration, consolidation, or quality that occurs despite adequate opportunity and circumstances for sleep, and results in some form of daytime impairment. The conventional treatments approved for management of insomnia were benzodiazepines (BZDs) (estazolam, quazepam, triazolam, flurazepam and temazepam) and non-BZDs, also known as z-drugs (zaleplon, zolpi...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Kumar A, Chanana P, Choudhary S Tags: Pharmacol Rep Source Type: research

Neuronal nitric oxide synthase has a role in the detrimental effects of lipopolysaccharide on spatial memory and synaptic plasticity in rats.
CONCLUSION: It is suggested that inhibition of nNOS by 7NI improves the deleterious effects of LPS by reducing NO metabolites and the brain tissues oxidative damage. PMID: 26922523 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Anaeigoudari A, Soukhtanloo M, Shafei MN, Sadeghnia HR, Reisi P, Beheshti F, Behradnia S, Mousavi SM, Hosseini M Tags: Pharmacol Rep Source Type: research

Pharmacological evaluation of novel 1-[4-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea as potent anticonvulsant and antidepressant agent.
CONCLUSION: BPPU displayed broad spectrum of anticonvulsant activity in several seizure models along with satisfactory antidepressant activity. Therefore, BPPU may be further developed as a potential therapeutic agent for therapy of epileptic disorders. PMID: 26922524 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Kumari S, Mishra CB, Tiwari M Tags: Pharmacol Rep Source Type: research

Assessment of the anticonvulsant potency of various benzylamide derivatives in the mouse maximal electroshock-induced seizure threshold model.
CONCLUSION: The studied benzylamide derivatives can be arranged with respect to their anticonvulsant potency in the MEST test as follows: Nic-BZA>2F-Pic-BZA>Pic-BZA>Me-Ala-BZA>Iso-Nic-BZA>Me-Pro-BZA. PMID: 26922525 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Świąder MJ, Paruszewski R, Łuszczki JJ Tags: Pharmacol Rep Source Type: research

The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect.
Abstract Depression is a serious global illness, becoming more and more common in developed countries. Because of specific symptoms it is considered as a leading cause of disability all over the world with a high death factor due to suicides. There are many antidepressants used in the therapy, but still more than 30% of patients do not respond to the treatment. The heterogeneous nature of the illness and its complex, unclear aetiology may be responsible for these difficulties. Next to the main monoaminergic hypothesis of depression there are also many other approaches connected with the pathophysiology of the dise...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Pytka K, Podkowa K, Rapacz A, Podkowa A, Żmudzka E, Olczyk A, Sapa J, Filipek B Tags: Pharmacol Rep Source Type: research

The heat shock protein 90 inhibitor, 17-AAG, attenuates thioacetamide induced liver fibrosis in mice.
CONCLUSION: The Hsp90 inhibitor, 17-AAG, can attenuate thioacetamide hepatotoxicity through oxidative stress counterbalance, reducing stellate cells activity and inducing apoptosis. PMID: 26922527 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Abu-Elsaad NM, Serrya MS, El-Karef AM, Ibrahim TM Tags: Pharmacol Rep Source Type: research

The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice.
CONCLUSIONS: Based on this preclinical study, a special caution is advised when treating epileptic patients with combinations of phenobarbital or carbamazepine with cimetidine. PMID: 26922528 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Świąder MJ, Barczyński B, Tomaszewski M, Świąder K, Czuczwar SJ Tags: Pharmacol Rep Source Type: research

The effect of an acute and 7-day administration of magnesium chloride on magnesium concentration in the serum, erythrocytes, and brain of rats.
CONCLUSIONS: Neither the brain nor the erythrocyte showed a change in the Mg level considerably after an increase in serum Mg level induced by the acute and subchronic administration of MgCl2 solution. PMID: 26922529 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Wlaź P, Serefko A, Szopa A, Poleszak E Tags: Pharmacol Rep Source Type: research

Effect of extended olanzapine administration on POMC and neuropeptide Y mRNA levels in the male rat amygdala and hippocampus.
CONCLUSIONS: Olanzapine can affect amygdalar and hippocampal neuronal populations by the modulation of neuropeptide activity. Importantly, it may suggest the existence of an alternative mode of its action. Undoubtedly this hypothetic regulatory mechanism requires further pharmacological and neurostructural study. PMID: 26922530 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Pałasz A, Bandyszewska M, Rojczyk E, Wiaderkiewicz R Tags: Pharmacol Rep Source Type: research

Protective action of nicotinic acid benzylamide in a variety of chemically-induced seizures in mice.
CONCLUSIONS: Summing up, Nic-BZA has a wide anticonvulsant effect in different experimental epilepsy models. PMID: 26922531 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Świąder MJ, Łuszczki JJ, Paruszewski R, Świąder K, Turski WA Tags: Pharmacol Rep Source Type: research

Facilitatory effect of AM281 on recognition memory in rats.
CONCLUSION: This is the first evidence that AM281 exerts facilitatory effect on recognition memory in rats. This effect seems to be memory specific because no alterations in animals' psychomotor activity and anxiety were observed. PMID: 26922532 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Bialuk I, Winnicka MM Tags: Pharmacol Rep Source Type: research

Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.
CONCLUSION: Overall, these findings confirm the chemopreventive potential of chrysin against B(a)P induced lung cancer in Swiss albino mice. PMID: 26922533 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Kasala ER, Bodduluru LN, Barua CC, Madhana RM, Dahiya V, Budhani MK, Mallugari RR, Maramreddy SR, Gogoi R Tags: Pharmacol Rep Source Type: research

n-3 Fatty acids regulate the inflammatory-state related genes in the lung epithelial cells exposed to polycyclic aromatic hydrocarbons.
CONCLUSIONS: Supplementation with n-3 FAs resulted in changes of inflammatory-state related genes in the lung epithelial cells exposed to PAHs. The altered profile of lipid mediators from n-3 FA as well as repression of the COX-2 protein by n-3 PUFAs in A549 cells incubated with PAHs suggests anti-inflammatory and pro-resolving properties of DHA and EPA. It remains to be shown whether these pleiotropic and protective actions of n-3 FAs contribute to fish oil's therapeutic effect in asthma. PMID: 26922534 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Gdula-Argasińska J, Czepiel J, Totoń-Żurańska J, Wołkow P, Librowski T, Czapkiewicz A, Perucki W, Woźniakiewicz M, Woźniakiewicz A Tags: Pharmacol Rep Source Type: research

Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner.
CONCLUSIONS: We showed that exenatide skewed the macrophages phenotype toward anti-inflammatory phenotype and this effect is predominantly attributable to protein kinase A and to a less extent to B/Akt activation. PMID: 26922535 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Bułdak Ł, Machnik G, Bułdak RJ, Łabuzek K, Bołdys A, Belowski D, Basiak M, Okopień B Tags: Pharmacol Rep Source Type: research

Effect of resveratrol on the pharmacokinetics of fexofenadine in rats: Involvement of P-glycoprotein inhibition.
CONCLUSIONS: RSV significantly enhanced the exposure of FEX in rats likely by the inhibition of P-glycoprotein (P-gp) mediated efflux during the intestinal absorption, suggesting that there is a potential pharmacokinetic interaction between RSV and FEX. Therefore, further studies are recommended to evaluate the potential drug-phytochemical interactions in humans. PMID: 26922536 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Bedada SK, Yellu NR, Neerati P Tags: Pharmacol Rep Source Type: research

Intensive statin therapy, used alone or in combination with ezetimibe, improves homocysteine level and lipid peroxidation to a similar degree in patients with coronary artery diseases.
CONCLUSION: Our results suggest that intensive lipid-lowering therapy has a beneficial effect on certain parameters of the blood of CAD patients. PMID: 26922537 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Pytel E, Jackowska P, Chwatko G, Olszewska-Banaszczyk M, Koter-Michalak M, Kubalczyk P, Broncel M Tags: Pharmacol Rep Source Type: research

Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity.
CONCLUSION: Hesperidin decreased cisplatin-induced functional and histopathological liver damage in a dose-dependent manner without affecting its potential cytotoxic effect. PMID: 26922538 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Omar HA, Mohamed WR, Arafa EA, Shehata BA, Sherbiny GA, Arab HH, Elgendy AN Tags: Pharmacol Rep Source Type: research

Ifenprodil for prolonged spinal blockades of motor function and nociception in rats.
CONCLUSIONS: The resulting data demonstrated that ifenprodil produces a dose-dependent local anesthetic effect in spinal anesthesia. Ifenprodil shows a more sensory-selective duration of action over motor block, whereas the duration of anesthesia is significantly longer with ifenprodil than with bupivacaine. PMID: 26922539 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Chen YW, Chiu CC, Wang JN, Hung CH, Wang JJ Tags: Pharmacol Rep Source Type: research

Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats.
CONCLUSION: Two weeks of URB597 administration to DOCA-salt hypertensive rats caused an age-specific reduction in BP, HR and cardiac and renal hypertrophy and did not affect the body weight, and water and food intake. Thus, caution should be taken during studies of FAAH inhibitors because of their potential age-specific effects. PMID: 26922540 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Toczek M, Baranowska-Kuczko M, Grzęda E, Pędzińska-Betiuk A, Weresa J, Malinowska B Tags: Pharmacol Rep Source Type: research

Renoprotective effect of diosgenin in streptozotocin induced diabetic rats.
CONCLUSION: The above study justifies diosgenin as a promising candidate in diabetes associated complication through its antioxidant and anti-inflammatory activity. PMID: 26922541 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Kanchan DM, Somani GS, Peshattiwar VV, Kaikini AA, Sathaye S Tags: Pharmacol Rep Source Type: research

The preventive role of levosimendan against bleomycin-induced pulmonary fibrosis in rats.
CONCLUSIONS: The results obtained from biochemical and histopathological evaluations indicate that levosimendan had an anti-fibrotic effect without a dose-dependent response on pulmonary fibrosis. PMID: 26922542 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Gürbüzel M, Sayar I, Cankaya M, Gürbüzel A, Demirtas L, Bakirci EM, Capoglu I Tags: Pharmacol Rep Source Type: research

The molecular basis of chloroethylclonidine block of inward rectifier (Kir2.1 and Kir4.1) K(+) channels.
CONCLUSIONS: Overall, our results suggest that differences in the cavity of Kir channels are determinants in its interactions with chloroethylclonidine. PMID: 26922543 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Rodríguez-Menchaca AA, Aréchiga-Figueroa IA, Sánchez-Chapula JA Tags: Pharmacol Rep Source Type: research

Odors identification differences in deficit and nondeficit schizophrenia.
CONCLUSIONS: No overall differences between DS and NDS regarding odors identification have been found. The results seem to indicate some specific deficits in the identification of markers of rose, pineapple, orange and cinnamon. PMID: 26922544 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Pełka-Wysiecka J, Wroński M, Bieńkowski P, Murawiec S, Samochowiec A, Samochowiec J Tags: Pharmacol Rep Source Type: research