The Poison Review The Poison Review RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the latest items in this publication.

State-of-the-art review of lithium poisoning: almost a must-read
4 out of 5 stars Lithium Poisoning: State of the Art.  Baird-Gunning J et al. J Intensive Care Med 2016 Aug 11 [Epub ahead of print] Abstract This is a very good paper, the best comprehensive review I can remember reading on lithium. It is up to date, with 78 references as recent as 2015. A major reason I liked it so much is that the authors are quire frank about how much we don’t know, and resist giving, for instance, mandates about when to start hemodialysis based on lithium levels. This is a temptation that the authors of the recent ExTRIP review  succumbed to. Interestingly, the two papers share an author (So...
Source: The Poison Review - August 20, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical lithium poisoning Review TUSH ultrasound Source Type: news

Elephant-tranquilizer (carfentanil)-tainted heroin showing up in Ohio
4 out of 5 stars Human Health Hazards of Veterinary Medications: Information for Emergency Departments. Lust EB et al. J Emerg Med 2011 Feb;40:198-207 Abstract Yesterday, Canadian police announced that, earlier in the summer, they had seized one kilogram of carfentanil contained in a package labelled “Printer Parts” shipped from China and addressed to a man in Calgary. Carfentanil is frequently, and accurately, referred to as an “elephant tranquilizer.” It is a fentanyl analog with a potency 10,000 times that of morphine (or 100 times that of fentanyl.) It is not approved for any medical indicatio...
Source: The Poison Review - August 10, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical animal tranquilizer carfentanil opiate opioid tainted heroin Source Type: news

Seven cases of laboratory-confirmed exposures to the synthetic cannabinoid MDMB-CHMICA
3 out of 5 stars Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification Of Novel psychoActive substances (IONA) study. Hill SL et al. Clin Toxicol 2016 Sep;54:638-643. Abstract MDMB-CHMICA is a synthetic cannabinoid receptor agonist (SCRA) with strong affinity for the CB1 receptor. It has to date not been banned in may localities, and is available on the street under labels such as “AK47 Loaded,” “Manga Hot,” “Black Diamond,” and “Sweet Leaf Obliteration.” It use has been associated w...
Source: The Poison Review - August 9, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical MDMB-CHMICA sweet leaf synthetic cannabinoid Source Type: news

Seven cases of laboratory-confirmed exposed to the synthetic cannabinoid MDMB-CHMICA
3 out of 5 stars Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification Of Novel psychoActive substances (IONA) study. Hill SL et al. Clin Toxicol 2016 Sep;54:638-643. Abstract MDMB-CHMICA is a synthetic cannabinoid receptor agonist (SCRA) with strong affinity for the CB1 receptor. It has to date not been banned in may localities, and is available on the street under labels such as “AK47 Loaded,” “Manga Hot,” “Black Diamond,” and “Sweet Leaf Obliteration.” It use has been associated w...
Source: The Poison Review - August 9, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical MDMB-CHMICA sweet leaf synthetic cannabinoid Source Type: news

Counterfeit Norco containing fentanyl and the synthetic opioid U-47700
3 out of 5 stars Fentanyl and a Novel Synthetic Opioid U-47700 Masquerading as Street “Norco” in Central California: A Case Report. Armenian P et al. Ann Emerg Med 2016 [Epub ahead of print] Full Text In a recent “Toxicology Rounds” column for Emergency Medicine News, I pointed out that designer opioids such as U-47700 are being identified in street drug specimens and overdose cases with increasing frequency. Knowing this, I was not really surprised when it was announced last week that the autopsy on music superstar Prince confirmed the presence of U-47700, as well as fentanyl. U-47700 is a synt...
Source: The Poison Review - July 29, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical counterfeit Norco synthetic opioid U-47700 Source Type: news

All bleeding stops — but does idarucizumab (Praxbind) make it stop faster?
3.5 out of 5 stars Persistent life-threatening hemorrhage after administration of idarucizumab. Alhashem HM et al. Am J Emerg Med 2016 June 30 [Epub ahead of print] Reference Dabigatran (Pradaxa) is a direct thrombin inhibitor approved for stroke and embolism prophylaxis in patients with non-valve-related atrial fibrillation. When it was first released in 2008, a major disincentive to widespread use was the lack of a reliable reversal agent to treat major bleeds, or to administer before necessary invasive procedures. In October 2015, the U.S. Food and Drug Administration approved idarucizumab (Praxbind), a monoclonal ant...
Source: The Poison Review - July 27, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical anticoagulant hemorrhage idarucizumab pradaxa praxbind reversal agent Source Type: news

A normal (or negative) anion gap does NOT rule out salicylate toxicity
3 out of 5 stars Salicylate toxicity in the absence of anion gap metabolic acidosis. Bauer S, Darracq MA. Am J Emerg Med  2016 Jul;34(7):1328.e1-3 Reference Moderate-to-severe salicylate toxicity typically presents with a combined metabolic acidosis and respiratory alkalosis. Often, the arterial blood gas shows a pH quite near the normal 7.4, but with decreased pCO2 and decreased bicarbonate. However, occasional case reports have shown that in these cases the anion cap may, rarely, but normal or even negative. This seems to be related to specific electrodes that measure chloride level loosing selectivity as they age, an...
Source: The Poison Review - July 23, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical anion gap aspirin poisoning laboratory error salicylate toxicity Source Type: news

Fentanyl can cause serotonin syndrome
3.5 out of 5 stars Serotonin Syndrome Induced by Fentanyl in a Child: Case Report. Robles LA. Clin Neuropharmacol 2015 Sept-Oct;38:206-8. Abstract When many clinicians think of serotonin syndrome (SS), they consider the usual suspects: Selective Serotonin Uptake Inhibitors (SSRIs) Citalopram Fluoxetine Sertraline Escitalopram Paroxetine Serotonin-Norepinephrine Reuptake Inhibitors Venlafaxine Duloxetine Antidepressants Trazodone Buspirone Clomipramine Aside from these common culprits, there are other commonly used drugs whose clear association with serotonin syndrome is less-often realized: Fentanyl Methadon...
Source: The Poison Review - July 8, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical fentanyl opioid serotonin syndrome Source Type: news

Loperamide (Imodium) overdose can cause fatal cardiac toxicity
A recent paper described two fatalities associated with overdose of the anti-diarrhea drug loperamide (Imodium.) This drug, once available by prescription only, had been thought so safe that in 1988 it was approved for purchase over-the-counter. Here are some important questions regarding this medication: Why is it sometimes called the “poor man’s methadone”? Why, despite having typical opiate μ-receptor activity, does it generally not cause respiratory or mental status depression? Why is P-glycoprotein (P-gp) important for understanding the pharmacokinetics of loperamide, and what does that have to do ...
Source: The Poison Review - July 4, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiotoxicity imodium loperamide opiate P-glycoprotein Source Type: news

Acetaminophen and N-acetylcysteine are removed by hemodialysis
3.5 out of 5 stars Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics. Ghannoum M et al. Clin Toxicol 2016 Jul;54:519-22. Abstract As we’ve discussed before, massive acetaminophen [APAP] overdose may be a somewhat different beast from the usual, run-of-the-mill case that reliably responds to N-acetylcysteine [NAC] (if administered at an early stage.)There is evidence that a very large intake of APAP (some say >500 mg/kg) can poison mitochondria, causing severe effects that manifest even before onset of hepatotoxicity. “Massive overdose” is suggested b...
Source: The Poison Review - June 30, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical acetaminophen acetylcysteine hemodialysis massive overdose Source Type: news

A can ’t miss item in the differential diagnosis of neuroleptic malignant syndrome
2 out of 5 stars Psychiatric Emergencies for Clinicians: Emergency Department Management of Neuroleptic Malignant Syndrome. Wilson MP et al. J Emerg Med 2016;51:66-69. Reference This review article about neuroleptic malignant syndrome (NMS) is brief but disappointing and misleading on some points. For example, the authors state that: The majority of cases of NMS develop symptoms within the first week [after starting the offending medication], and virtually all develop symptoms within the first 30 days. The clinician who takes this statement to the bank could easily miss late-onset NMS occurring as a result of dose change,...
Source: The Poison Review - June 23, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical anti-NMDA receptor encephalitis dantrolene neuroleptic malignant syndrome Source Type: news

A can’t miss item in the differential diagnosis of neuroleptic malignant syndrome
2 out of 5 stars Psychiatric Emergencies for Clinicians: Emergency Department Management of Neuroleptic Malignant Syndrome. Wilson MP et al. J Emerg Med 2016;51:66-69. Reference This review article about neuroleptic malignant syndrome (NMS) is brief but disappointing and misleading on some points. For example, the authors state that: The majority of cases of NMS develop symptoms within the first week [after starting the offending medication], and virtually all develop symptoms within the first 30 days. The clinician who takes this statement to the bank could easily miss late-onset NMS occurring as a result of dose change,...
Source: The Poison Review - June 23, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical anti-NMDA receptor encephalitis dantrolene neuroleptic malignant syndrome Source Type: news

Rant: ultrasound visualization of pills in the stomach will never make sense
Konstantin Shevtsov/shutterstock.com 2 out of 5 stars Accuracy of Trans-Abdominal Ultrasound in a Simulated Massive Acute Overdose. Sullivan S et al.  Am J Emerg Med 2016 Apr 23 [Epub ahead of print] Abstract As soon as emergency portable bedside ultrasound became feasible approximately three decades ago, toxicologists wondered if it would be a useful modality for visualizing pills in the stomach of overdose patients. The answer, clearly, is no it would not. This misguided paper illustrates why. This randomized study had a study group (N=10) and a control group (N=10) ingest 50 enteric-coated placebo capsules plus 1 L fl...
Source: The Poison Review - May 25, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical activated charcoal acute ingestion gastric lavage sonography ultrasound whole bowel irrigation Source Type: news

5-MAPB: a novel psychoactive benzofuran
3.5 out of 5 stars Acute Toxicity Associated With the Recreational Use of the Novel Psychoactive Benzofuran N-methyl-5-(2 aminopropyl)benzofuran. Sofer KE et al. Ann Emerg Med 2016 Apr 26 [Epub ahead of print] Abstract 5-MAPB is a psychoactive benzofuran with a structure and effects similar to those of MDMA (Ecstasy.) Although there has been scant investigation of its pharmacologic and toxic effects, animal studies indicate that it inhibits re-uptake of monoamines, especially serotonin. This case report from Zurich Switzerland describes a patient with laboratory-confirmed exposure to 5-MAPB. He presented with signs an...
Source: The Poison Review - May 24, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical 5-MAPB 5_APB bensofuran benzo fury ecstasy mdma psychoactive Source Type: news

Absolute must-read: LA Times on the myth of OxyContin’s 12-hour analgesic effect
Quick: how long does a dose of Oxycontin provide pain relief? Most clinicians would probably say 12 hours, since the drug was extensively marketed as a twice-daily opioid analgesic and the manufacturer — Purdue Pharma — cited this originally unique convenience factor as justifying its high cost, which could exceed $630 a bottle. In an explosive and masterfully written investigative piece by Harriet Ryan, Lisa Girion and Scott Glover,  the Los Angeles Times reported this week that in most patients the duration of the analgesic effect for OxyContin does not last nearly as long as claimed, and that this discrepancy may b...
Source: The Poison Review - May 8, 2016 Category: Toxicology Authors: Leon Gussow Tags: Best of TPR Medical 12-hour myth Los Angeles Times opiate opioid addiction oxycontin Purdue Pharma Source Type: news

Cardiac effects of loperamide overdose
3 out of 5 stars Not your regular high: cardiac dysrhythmias caused by loperamide. Wightman RS et al. Clin Toxicol 2016 Jun;54:454-458 Abstract Loperamide is an over-the-counter anti-diarrhea medication that is available without prescription under a variety of brand names including Imodium. In therapeutic doses, loperamide acts as a peripheral mu-opioid receptor agonist but doesn’t cross the blood-brain barrier (BBB). However, in massive overdose loperamide can enter the brain and cause central opioid toxicity, including altered mental status and respiratory. Although previously loperamide was thought to have litt...
Source: The Poison Review - April 30, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiac effects cardiogoxicity long QT loperamide overdose QRS interval qt interval Source Type: news

Bedside echocardiography findings in carbon monoxide-poisoned patients
4 out of 5 stars Incidence and patterns of cardiomyopathy in carbon monoxide-poisoned patients with myocardial injury. Cha YS et al. Clin Toxicol 2016 Apr 11 [Epub ahead of print] Abstract At last year’s Social Media and Critical Care (SMACC) conference in Chicago, I gave a talk remarking on how bedside ultrasound imaging in critically ill toxicology patients is underused and little studied. I suggested that it could provide crucial information in a number of settings. For example, visualizing the inferior vena cava (IVC) in salicylate toxicity to help guide rehydration, or evaluating left ventricular (LV) function...
Source: The Poison Review - April 29, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical bedside emergency ultrasound carbon monoxide cardiomyopathy echocardiography left ventricular dysfunction takotsubo Source Type: news

NBC Nightly News: Fentanyl Overdoses on the Rise
NBC Nightly News on the skyrocketing numbers of overdose deaths attributed to fentanyl. And yes, that is Steve Aks at 2:14. (Source: The Poison Review)
Source: The Poison Review - April 26, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical deaths fatality fentanyl NBC Nightly News overdoses Source Type: news

Metronidazole-induced cerebellar syndrome
3.5 out of 5 stars Metronidazole-Associated Encephalopathy. Farmakiotis D, Zeluff B. N Engl J Med 2016 Apr 14;374:1465 Full Text            Exposure to metronidazole (Flagyl) can precipitate a subacute cerebellar syndrome, typically manifested with dysarthria and ataxia, with or without cognitive impairment. This adverse effect is uncommon and little-appreciated. Although usually associated with prolonged exposure to the antibiotic for treatment of conditions such as abscesses of Clostridium difficile-associated diarrhea and occurring after total cumulative dose > 20 gm, the syndrome can occur after lower dose...
Source: The Poison Review - April 15, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical acute cerebellar syndrome encephalopathy metronidazole miri neurotoxicity Source Type: news

Vasculitis after snorting cocaine contaminated with levamisole
Lawrence et al. Allergy Rhinol (Providence) 2014Copyright policy — open-access 3.5 out of 5 stars Cocaine-induced ecchymotic rash. Voore NK. Cleve Clin J Med 2016 Apr;3:252-253. Full Text Since at least 2010, a large percentage of cocaine samples seized in the United States has contained levamisole, a veterinary anti-worm medication. Levamisole had previously used in humans as an anti-helminthic and also in some chemotherapy regimens. It was withdrawn from the U.S. market in 1999 because of its association with agranulocytosis and vasculitis. It is apparently added to cocaine because it increases catecholamine release, ...
Source: The Poison Review - April 7, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cocaine levamisole vasculitis Source Type: news

Cocaine-associated cardiotoxicity: a systematic review yields no answers
Christopher Siesarchik/shutterstock.com 3 out of 5 stars Treatment of cocaine cardiovascular toxicity: a systematic review. Richards JR et al. Clin Toxicol 2016 Feb 26 [Epub ahead of print] Abstract This paper is the most frustrating thing I’ve read since I force marched my way through the “Oxen of the Sun” chapter of James Joyce’s Ulysses. I must say that, despite its difficulties, the Joyce selection — with its obstetric setting and drunken medical students — was much more fun. There is considerable controversy among toxicologists, emergency physicians, and cardiologists as to the best agent...
Source: The Poison Review - April 6, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiotoxicity cocaine systematic review Source Type: news

Is ketamine safe and effective in excited delirium?
Zerbor/shutterstock.com 3 out of 5 stars Ketamine as Rescue Treatment for Difficult-to-Sedate Severe Acute Behavioral Disturbance in the Emergency Department. Isbister GK et al. Ann Emerg Med 2016 Feb 10 [Epub ahead of print] Abstract Rapidly sedating a toxicology patient who presents with excited delirium is a critical — yet often difficult — action. These patients are typically difficult to control and resistant to sedation with commonly used agents such as benzodiazepines and antipsychotics. They also have high mortality rates. The key to obtaining good outcomes in these cases is prompt evaluation and support, focus...
Source: The Poison Review - March 29, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical excited delirium ketamine sedation Source Type: news

Is possible chest wall rigidity after illicit intravenous fentanyl administration clinically significant?
3 out of 5 stars Could chest wall rigidity be a factor in rapid deaths from illicit fentanyl abuse? Burns G et al. Clin Toxicol 2016 Mar 21 [Epub ahead of print] Abstract “Wooden chest syndrome” describes marked muscle rigidity — especially involving the thoracic and abdominal muscles — that is an occasional adverse effect associated with the intravenous administration of lipophilic synthetic opioids such as fentanyl. It can make ventilation difficult, and seems to be reversed by naloxone. The authors of this interesting speculative paper hypothesized that chest wall rigidity might be at least partially re...
Source: The Poison Review - March 26, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical chest wall rigidity fentanyl wooden chest Source Type: news

---
Ti Santi/shutterstock.com 3.5 out of 5 stars Start me up! Recurrent ventriculat tachydysrhythmias following intentional concentrated caffeine ingestion. Laskowski LK et al. Clin Toxicol 2015;53:830-833. Abstract   (Source: The Poison Review)
Source: The Poison Review - March 22, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical Source Type: news

TPR Podcast Episode #11: Google Glass and the Toxicologist
, with Dr. Peter Chai   Written by Leon Gussow MD FACMT   In this episode, Steve Aks and I talk to Dr. Peter Chai, a senior medical toxicology fellow at the University of Massachusetts in Worcester, about his research on Google Glass and its potential use as an aid to consultation on poisoned patients.     Google Glass has the potential of giving us a new perspective on telemedicine. However, the use of this device presents several problems, especially involving data security, patient privacy and HIPAA compliance.   “Google Glass” is a head-mounted computer that can both receive and transmit data. ...
Source: The Poison Review - March 19, 2016 Category: Toxicology Authors: Leon GussowThe Poison Review Tags: Podcast Source Type: news

Sunday with SMACC: Amal Mattu on Lessons Learned from The Princess Bride
As the 2016 Social Media and Critical Care (SMACC) conference fast approaches — it will take place June 13-16 in Dublin — let’s look back on one my favorite talks from last years smaccCHICAGO get together. It’s Amal Mattu reflecting on lessons important to both life and emergency medicine contained in the 1987 film The Princess Bride. As with all of Amal’s talks, it is full of wisdom and highly entertaining. To hear the talk click here, and be sure to follow along with the slides. By the way, tickets for SMACC Dublin were snapped up quickly and are completely sold out. However, two “Golden Ticke...
Source: The Poison Review - February 29, 2016 Category: Toxicology Authors: Leon Tags: Medical Amal Mattu dublin SMACC 2016 The Princess Bride Source Type: news

Shiitake happens: dermatitis from uncooked mushrooms
puttography/shutterstock.com 3.5 out of 5 stars Shiitake dermatitis: the tale of an under-recognised, undercooked fungus. McNally A et al. Med J Aust 2016 Feb 15;204:124-6 Reference   Just when you thought it was safe to go back to the farmers’ market . . . This interesting paper presents a series of 3 cases of flagellate dermatitis following consumption of raw or undercooked shiitake mushrooms. The rashes described were linear, pruritic, and papular, sparing areas such as the mid-back that could not be reached for scratching. All of these factors suggested that lesions were caused by the Koebner phenomenon. S...
Source: The Poison Review - February 20, 2016 Category: Toxicology Authors: Leon Tags: Medical flagellate dermatitis lentinan mushroom poisoning shiitake Source Type: news

Tox Tunes #106: Mountain Dew (The Stanley Brothers)
Long before there was the soft drink, the term “mountain dew” referred to bootleg whiskey. Actually, the use of the term may have been brought over from Ireland. According to the Merriam-Webster dictionary, the use of the term to denote illegal alcohol goes back to the 1800s. When I went to camp as a teenager, this was one of our favorite songs to sing around the campfire. (Yes, it was that kind of camp.) My favorite version by far is that recorded by the great bluegrass duo Ralph and Carter Stanley — The Stanley Brothers. (Source: The Poison Review)
Source: The Poison Review - February 15, 2016 Category: Toxicology Authors: Leon Tags: Medical mountain dew stanley brothers tox tunes Source Type: news

Saturday with SMACC: Ho v Bellezzo debate — ECMO is a step too far
One of my favorite sessions from SMACC Chicago last year was the the debate between Chris Ho and Joe Bellezzo — both from Sharp Memorial Hospital in San Diego. Dr. Ho — on the resolution: ECPR (extracorporeal cardiopulmonary resuscitation) is a step to far. Dr. Ho took the affirmative side, arguing that ECPR (with is the same as ECMO) was not backed by any evidence of efficacy, horrendously expensive, resource-intensive, fraught with complications, and unethical. Dr. Bellezzo countered that all of his opponents objections were “bullshit.” The session was entertaining but also dead serious. To listen, click ...
Source: The Poison Review - February 14, 2016 Category: Toxicology Authors: Leon Tags: Medical Chris Ho ECMO ECPR extracorporeal cardiopulmonary resuscitation extracorporeal membrane oxygenation Joe Bellezzo saturday with smack SMACC Source Type: news

Severe bupropion overdose and ECMO: two great saves
ChaNaWiT/shutterstock.com 3.5 out of 5 stars Two Cases of Refractory Cardiogenic Shock Secondary to Bupropion Successfully Treated with Veno-Arterial Extracorporeal Membrance Oxygenation. Heise CW et al. J Med Toxicol 2016 Feb 8 [Epub Ahead of Print] Abstract This awesome, exciting paper from Banner University Medical Center in Phoenix describes two teenagers with severe bupropion overdose who survived refractory cardiac arrest after veno-arterial extracorporeal membrane oxygenation (VA-ECMO): Case 1: A 15-year-old girl was brought to hospital after ingesting up to 90 150-mg bupropion tablets. She had a seizure en route...
Source: The Poison Review - February 12, 2016 Category: Toxicology Authors: Leon Tags: Medical burpropion ECMO extracorporeal membrane oxygenation Source Type: news

Case report: Amanita muscaria (fly agaric) poisoning
Mikhail Kochlev/shutterstock.com 2 out of 5 stars Coma in the course of severe poisoning after  consumption of red fly agaric (Amanita muscaria). Mikaszewska-Sokolewicz MA et al. Acta Biochim Pol 2016 Feb 1 [Epub ahead of print] Full Text Probably the most recognizable mushroom in the world is Amanita muscaria (the “fly agaric”), This striking red-and-white fungus contains several distinct neurotoxins: ibotenic acid:  this toxin is structurally similar to the excitatory neurotransmitter glutamic acid muscimol: structurally similar to GABAA  this is the main psychoactive component of A muscaria producin...
Source: The Poison Review - February 9, 2016 Category: Toxicology Authors: Leon Tags: Medical amanita muscaria fly agaric isotonic acid muscimol mushroom poisoning Source Type: news

W-18, a synthetic opiate 100 times more potent than fentanyl
W-18 Last August, Canadian police seized 110 illegal fentanyl pills at a home in Alberta province. Yesterday, Global News reported that some of the pills have tested positive for an extremely potent opioid called W-18. This is certainly a disturbing development, since W-18 is a μ-receptor agonist 100 times more potent than fentanyl. According to B.C. Centre for Disease Control, W-18 is one of a series of 32 synthetic opioids discovered in the 1980s at the University of Alberta. W1 thru W19 are pure μ-receptor agonists; W20 thru W32 are agonist-antagonists (as is buprenorphine.)  W-18 seems to be the most powerful agonis...
Source: The Poison Review - February 4, 2016 Category: Toxicology Authors: Leon Tags: Best of TPR Medical fentanyl opiate opioid w-18 Source Type: news

Coronary artery vasospasm induced by cocaine (maybe)
2.5 out of 5 stars Cocaine-Induced Coronary Artery Vasospasm. Almaddah N, Ajayi TO. N Engl J Med 2016 Feb 4;374:e5 Full Text with video In a series of amazing studies that are now about three decades old, Richard Lange and his colleagues at Parkland Hospital in Dallas investigated the cardiovascular effects of administering intranasal cocaine to patients to patients during cardiac catheterization for routine workup of chest pain. In an initial study, the group demonstrated that cocaine produced coronary artery vasoconstriction that was relieved by nitroglycerin and exacerbated by smoking a cigarette and also by ad...
Source: The Poison Review - February 4, 2016 Category: Toxicology Authors: Leon Tags: Medical cardiovascular effects cocaine coronary artery vasospasm Source Type: news

Tox Tunes #105: How Can a Poor Man Stand Such Times and Live (Ry Cooder)
Well the doctor comes around with a face all bright, And he says in a little while you’ll be all right. All he gives is a humbug pill, A dose of dope and a great big bill — Tell me how can a poor man stand such times and live? “How Can a Poor Man Stand Such Times and Live” was written by Blind Alfred Reed (1880-1956), who recorded it about a month after the stock market crash in 1929 that heralded the Great Depression. This great cover by Ry Cooder features a first-rate band including the legendary Flaco Jiménez on accordion. This cut was taken from a 1987 concert at The Catalyst in Santa Cruz. Th...
Source: The Poison Review - February 1, 2016 Category: Toxicology Authors: Leon Tags: Medical blind alfred reed flaco jimenez how can a poor man stand such times and live ry cooder tox tunes Source Type: news

Saturday with SMACC: Strayer on how to use opioids (and how not to use opioids)
The 3rd (and final) release of registrations for the 2016 Social Media and Critical Care (SMACC) conference in Dublin (June 13-16) will take place on February 3 at 09:00 Sydney time — or 4 pm Tuesday February 2 Chicago time. The 2nd release early December sold out in just one hour (!) after being posted,  so if you’re interested in attending plan accordingly. The program and registration details for the conference can be accessed at the smaccDUB website. To get a taste of what’s in store for Dublin, here’s a talk from last year’s smaccCHICAGO — Reuben Strayer’s excellent talk o...
Source: The Poison Review - January 31, 2016 Category: Toxicology Authors: Leon Tags: Medical addiction dublin epidemic opiate opioid SMACC smaccdub social media and critical care Source Type: news

Cannabis psychopharmacology: it’s more complex than you might imagine
Yarygin/shuttershock.com 3.5 out of 5 stars The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD. Cannabis and Cannabinoid Research 2016 Jan;1:44-46 Full Text This short interview with Ethan Russo MD should be of interested to toxicologists and other clinicians who might counsel patients on issues regarding medical marijuana. It contains some interesting information about the different biologically active chemicals contained in cannabis plants, and their effects. These chemicals include: Δ9-tetrahydrocannabinol (THC) – main psychoactive chemical in Cannabis cannabinol – bre...
Source: The Poison Review - January 30, 2016 Category: Toxicology Authors: Leon Tags: Medical cannabidiol cannabinol cannabis cannabis indica cannabis sativa marijuana myrcene pinene THC Source Type: news

Extracorporeal treatment for digoxin toxicity: just say no
3 out of 5 stars Extracorporeal treatment for digoxin poisoning: systematic review and recommendations from the EXTRIP Workgroup. Mowry JB et al. Clin Toxicol 2016 Feb;54:103-14. Abstract “Forced diuresis, and hemodialysis are ineffective in enhancing the elimination of digoxin because of its large volume of distribution (4-10 L/kg), which makes it relatively inaccessible to these techniques.” Goldfrank’s Toxicologic Emergencies (Tenth Edition, 2015) That one sentence from the latest edition of Goldfrank’s tells you all you need to know about the use of extracorporeal treatment (ECTR)  in digoxin...
Source: The Poison Review - January 28, 2016 Category: Toxicology Authors: Leon Tags: Medical digoxin toxicity extracorporeal treatment extrip Fab fragment hemodialysis hemoperfusion Source Type: news

Tox on the Web: deadly French drug trial, fatal food, and more!
    Must-read post about the catastrophic phase 1 French drug trial: In a superb must-read post at the Forbes magazine website,  David Kroll discusses what we know about the disastrous drug safety trial in France that left 1 subject dead and 4 others with varying degrees of neurological damage.The drug in question — named BIA 10-2474 — is an inhibitor of the enzyme fatty acid amide hydrolase (FAAH) that was being developed as a new oral analgesic. As Kroll explains: What’s so important about FAAH? Our bodies make several fatty acid amides that include anandamide, a natural stimulator of the cannabinoi...
Source: The Poison Review - January 24, 2016 Category: Toxicology Authors: Leon Tags: Medical bia 10-2474 fatty acid amide hydrolase inhibitor litvenenko polonium-210 putin tox on the web Source Type: news

Happy Birthday, Wilbur Scoville! (1865-1942)
Pass the Carolina Reaper! (Source: The Poison Review)
Source: The Poison Review - January 22, 2016 Category: Toxicology Authors: Leon Tags: Medical Source Type: news

Definitive paper on phenytoin/phosphenytoin-associated purple glove syndrome
Purple glove syndrome (fda.gov) 4.5 out of 5 stars Purple Glove Syndrome after Phenytoin or Fosphenytoin Administration: Review of Reported Cases and Recommendations for Prevention. Garbovsky LA et al. J Med Toxicol 2015 Dec;11:445-459. Abstract Purple glove syndrome (PGS) is an uncommon adverse drug reaction to parenteral administration of phenytoin or fosphenytoin marked by severe progressive soft tissue discoloration, swelling and pain in the distal extremity into which the drug was infused. This extremely well done and comprehensive paper will tell you all you need to know (well, probably more than you need to know) ...
Source: The Poison Review - January 22, 2016 Category: Toxicology Authors: Leon Tags: Medical adverse drug reaction dilantin phenytoin phosphenytoin purple glove syndrome soft tissue Source Type: news

Review of synthetic cannabinoids out-of-date as soon as it’s published
3 out of 5 stars A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment. Tait RJ et al. Clin Toxicol 2016 Jan;54:1-13. Abstract This paper review clinical literature related to use of synthetic cannabinoids (SCs) through the end of 2015. Although it seems comprehensive, and cites 108 references, it is of course already at least 18 months out-of-date. The number of cases involving exposure to SC surged during 2015. For example, although the authors of this paper identified 22 deaths associated with SCs, according to CDC data in the first 6 months of 2015 alone ...
Source: The Poison Review - January 20, 2016 Category: Toxicology Authors: Leon Tags: Medical K2 spice synthetic cannabinoids systematic review Source Type: news

Must-read: combination acetaminophen-opioid formulations should be abandoned
4 out of 5 stars The prescription paradox of acetaminophen safety. Dart RC, Green JL. Pharmacoepidemiol Drug Saf 2015 Dec 29 [Epub ahead of print] Reference Last week, we pointed out that the American College of Medical Toxicology (ACMT) had issued a position statement on prescribing opioids that had missed a good opportunity to call for abandoning use of pharmaceutical products that combined strong opioids such as hydrocodone with acetaminophen. I just discovered that a recent editorial by Richard Dart and Jody Green from the Rocky Mountain Poison and Drug Center agree with my take on this matter. They point out that a re...
Source: The Poison Review - January 13, 2016 Category: Toxicology Authors: Leon Tags: Medical acetaminophen adverse effects hepatotoxicity opioid Source Type: news

Tox Tunes #104: Oxycontin Blues (Steve Earle)
This is from Steve Earle’s 2007 CD Washington Square Serenade. The lyrics are simple and stark: Well my daddy worked in the coal mine Till the company shut it down Then he sat around and drank his self blind Till we put him back underground Now nothing grows on this mountain And what’s a poor boy to do Except to wander these hills forgotten With the oxycontin blues Of course, in the nearly decade since this song came out, we’ve become all too aware that the “oxycontin blues” is an problem that has spread far beyond the coal region and Appalachia. Thanks to reader @kimvie for suggesting this ...
Source: The Poison Review - January 11, 2016 Category: Toxicology Authors: Leon Tags: Medical oxycontin blues Steve Earle tox tunes Source Type: news

Saturday with SMACC: Tox Dogmalysis
The 4th annual Social Media and Critical Care (SMACC) conference will take place in Dublin (Ireland, not California) later this year from June 13 through June 16. I’m really looking forward to it, both because last year’s meeting in Chicago was so much fun, and because the last day of the Dublin conference — June 16 —coincides with Bloomsday, the day James Joyce’s novel Ulysses takes place and the occasion every year for a huge festival in Dublin. The first two releases of tickets to SMACC Dublin sold out quickly. The third and last batch of tickets will be available in early February and are expecte...
Source: The Poison Review - January 10, 2016 Category: Toxicology Authors: Leon Tags: Medical benzodiazepine poisoning beta blocker Bryan Hayes calcium cocaine chest pain digoxin poisoning flumazenil hyperkalemia SMACC SMACC Chicago tox dogmalysis Source Type: news

ACMT position statement on prescribing opioids: a missed opportunity
3 out of 5 stars Safety Issues Regarding Prescription Opioids. American College of Medical Toxicology J Med Toxicol 2016 Jan 5 [Epub ahead of print] No abstract available This “Position Statement” from the American College of Medical Toxicology (ACMT) covers 3 topics related to safety issues associated with use of prescription opioids. Unfortunately, some of the positions taken by the College are, to say the least, wishy-washy, and represent a missed opportunity to make some important points forcefully. The first topic addressed in this statement involves the use of medications that combine acetaminophen with a...
Source: The Poison Review - January 7, 2016 Category: Toxicology Authors: Leon Tags: Medical american college of medical toxicology opiates opioids position statement prescribing Source Type: news

The 6th Annual Alexander Awards: The Best Tox Reading of 2015
Alexander Gettler At the end of every year, TPR bestows the coveted Alexander Awards on the best long-form writing on toxicology topics that have appeared in the popular press during the preceding 12 months. To be eligible, an article must be open-access and freely available, not locked behind some paywall. The awards were named for Alexander Gettler (1883-1968,) the head of toxicology for the Office of the Chief Medical Examiner on the City of New York during the first half of the 20th century. Gettler has been called the “father of forensic toxicology in America.” His work was vividly described in Deborah Blu...
Source: The Poison Review - January 1, 2016 Category: Toxicology Authors: Leon Tags: Medical Alexander awards arsenic earth and fire erowid erowid.org marsh test opiates opioids spice spike synthetic cannabinoids Source Type: news

Carbon monoxide “myths”
2.5 out of 5 stars Myth busting in carbon monoxide poisoning. Hampson NB. Am J Emerg Med 2015 Nov 3 [Epub ahead of print] Abstract This short review, by the former medical director for the Virginia Mason Center for Hyperbaric Medicine in Seattle, sets out to debunk four “myths” associated with carbon monoxide (CO) exposure. Although nothing here will surprise most emergency physicians, the paper may be worth a quick look. The “myths” discussed are: The caboxyhemoglobin (COHb) level correlates with symptoms in acute CO poisoning: What really matters is CO in the cells and central nervous system, no...
Source: The Poison Review - December 24, 2015 Category: Toxicology Authors: Leon Tags: Medical carbon monoxide toxicity myths Source Type: news

TPR Podcast Episode #10: Synthetic cannabinoids, “Crazy Monkey,” and a man and his dog
Episode #10: The Rise of Synthetic Cannabinoids…and Crazy Monkeys Written by Theresa Kim, M.D.   Highlights According to reports from the CDC, an increasing number of calls to poison centers for synthetic cannabinoid exposure has been noted on a local as well as national level A report in the Morbidity and Morality Weekly (MMWR) published June 2015 cites a 330% increase monthly incidence nationwide from January 2015 to April 2015 A report in the MMWR published April 2015 cites 721 suspected cases including 9 deaths at the Mississippi Control Center from April 2 to May 3 Most commonly reported adverse effects T...
Source: The Poison Review - December 17, 2015 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news

TPR Podcast Episode #10: Synthetic cannabdinois, “Crazy Monkey,” and a man and his dog
Episode #10: The Rise of Synthetic Cannabinoids…and Crazy Monkeys Written by Theresa Kim, M.D.   Highlights According to reports from the CDC, an increasing number of calls to poison centers for synthetic cannabinoid exposure has been noted on a local as well as national level A report in the Morbidity and Morality Weekly (MMWR) published June 2015 cites a 330% increase monthly incidence nationwide from January 2015 to April 2015 A report in the MMWR published April 2015 cites 721 suspected cases including 9 deaths at the Mississippi Control Center from April 2 to May 3 Most commonly reported adverse effects T...
Source: The Poison Review - December 17, 2015 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news

Tox Tunes # 103: I’ll Never Smoke Weed with Willie Again (Toby Keith & Scott Emerick)
Yesterday we linked to a New York Magazine piece about Willie Nelson and his relationship with marijuana. As described in the article: . . . Nelson’s tolerance is supernatural. He can easily smoke 30 or 40 hits in a session and then play a flawless two-hour show. He does not always deploy this talent toward noble ends. He is famous for smoking new friends to oblivion and then challenging them to a few hands of high-stakes poker. Willie’s game is cash-only, and all debts must be settled at the table. Toby Keith’s song “I’ll Never Smoke Weed with Willie Again” apparently was written after one suc...
Source: The Poison Review - December 13, 2015 Category: Toxicology Authors: Leon Tags: Medical i'll never smoke weed with willie again toby keith tox tunes willie nelson Source Type: news