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Prediction and prophylaxis of hepatocellular carcinoma occurrence and postoperative recurrence in chronic hepatitis B virus-infected subjects.
Abstract Hepatocellular carcinoma (HCC) is one of the most common and highly fatal malignancies worldwide. Chronic infection with hepatitis B virus (HBV) is a major cause of HCC. High HBV replication rate and related non-resolving inflammation are the major risk factors of HCC occurrence and postoperative recurrence. Early prophylactic options are effective in reducing HCC occurrence and improving survival. Therefore, it is important to identify HBV-infected patients who are at a higher risk of developing HCC and HBV-HCC patients who are more likely to relapse after surgery, thus providing them with more precise p...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Du Y, Han X, Ding YB, Yin JH, Cao GW Tags: World J Gastroenterol Source Type: research

Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance.
Abstract The use of direct-acting antivirals (DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response (around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity ...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Jiménez-Pérez M, González-Grande R, España Contreras P, Pinazo Martínez I, de la Cruz Lombardo J, Olmedo Martín R Tags: World J Gastroenterol Source Type: research

Progress in systemic therapy of advanced hepatocellular carcinoma.
Abstract Primary liver cancer, mainly consisting of hepatocellular carcinoma (HCC), is one of common malignancies worldwide, and prevalent among the Chinese population. A diagnosis of early stage HCC has proven to be very difficult because of its insidious feature in onset and development. At the time of diagnosis, most HCC cases are locally advanced and/or distant metastatic, which results in difficulty to be treated and poor prognosis. For advanced HCC, systemic therapy is frequently adopted as an important palliative method. In recent years, clinical studies and observations have often reported about systemic a...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Gong XL, Qin SK Tags: World J Gastroenterol Source Type: research

Management of a large mucosal defect after duodenal endoscopic resection.
Abstract Duodenal endoscopic resection is the most difficult type of endoscopic treatment in the gastrointestinal tract (GI) and is technically challenging because of anatomical specificities. In addition to these technical difficulties, this procedure is associated with a significantly higher rate of complication than endoscopic treatment in other parts of the GI tract. Postoperative delayed perforation and bleeding are hazardous complications, and emergency surgical intervention is sometimes required. Therefore, it is urgently necessary to establish a management protocol for preventing serious complications. For...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Fujihara S, Mori H, Kobara H, Nishiyama N, Matsunaga T, Ayaki M, Yachida T, Masaki T Tags: World J Gastroenterol Source Type: research

Noncoding RNAs in gastric cancer: Research progress and prospects.
Abstract Noncoding RNAs (ncRNAs) have attracted much attention in cancer research field. They are involved in cellular development, proliferation, differentiation and apoptosis. The dysregulation of ncRNAs has been reported in tumor initiation, progression, invasion and metastasis in various cancers, including gastric cancer (GC). In the past few years, an accumulating body of evidence has deepened our understanding of ncRNAs, and several emerging ncRNAs have been identified, such as PIWI-interacting RNAs (piRNAs) and circular RNAs (circRNAs). The competing endogenous RNA (ceRNA) networks include mRNAs, microRNAs,...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Zhang M, Du X Tags: World J Gastroenterol Source Type: research

Inflammatory microenvironment contributes to epithelial-mesenchymal transition in gastric cancer.
Abstract Gastric cancer (GC) is the fifth most common malignancy in the world. The major cause of GC is chronic infection with Helicobacter pylori (H. pylori). Infection with H. pylori leads to an active inflammatory microenvironment that is maintained by immune cells such as T cells, macrophages, natural killer cells, among other cells. Immune cell dysfunction allows the initiation and accumulation of mutations in GC cells, inducing aberrant proliferation and protection from apoptosis. Meanwhile, immune cells can secrete certain signals, including cytokines, and chemokines, to alter intracellular signaling pathwa...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Ma HY, Liu XZ, Liang CM Tags: World J Gastroenterol Source Type: research

Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis.
In conclusion, MACC1 participates in multiple biological processes inside and outside of GC cells, making it an important mediator of the tumor microenvironment. PMID: 27547006 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Wu ZZ, Chen LS, Zhou R, Bin JP, Liao YL, Liao WJ Tags: World J Gastroenterol Source Type: research

Use of rifaximin in gastrointestinal and liver diseases.
Abstract Rifaximin is a broad spectrum oral antibiotic with antimicrobial activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. It is poorly absorbed and thus has a highly favorable safety profile. Rifaximin has been shown to be effective in the treatment of traveler's diarrhea, functional bloating and irritable bowel syndrome, small bowel bacterial overgrowth and in the prevention of recurrent overt hepatic encephalopathy. In addition, there is emerging evidence for a possible beneficial effect of rifaximin in the treatment of uncomplicated diverticular disease and in the prevention of ...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Shayto RH, Abou Mrad R, Sharara AI Tags: World J Gastroenterol Source Type: research

MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling.
Abstract Liver fibrosis is a repair process in response to damage in the liver; however, severe and chronic injury promotes the accumulation of fibrous matrix, destroying the normal functions and architecture of liver. Hepatic stellate cells (HSCs) are quiescent in normal livers, but in damaged livers, they transdifferentiate into myofibroblastic HSCs, which produce extracellular matrix proteins. Hedgehog (Hh) signaling orchestrates tissue reconstruction in damaged livers and contributes to liver fibrogenesis by regulating HSC activation. MicroRNAs (miRNAs), endogenous small non-coding RNAs interfering with RNA po...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Hyun J, Jung Y Tags: World J Gastroenterol Source Type: research

Noninvasive models for assessment of liver fibrosis in patients with chronic hepatitis B virus infection.
Abstract There are approximately 240 million patients with chronic hepatitis B virus (HBV) infection worldwide. Up to 40% of HBV-infected patients can progress to liver cirrhosis, hepatocellular carcinoma or chronic end-stage liver disease during their lifetime. This, in turn, is responsible for around 650000 deaths annually worldwide. Repeated hepatitis flares may increase the progression of liver fibrosis, making the accurate diagnosis of the stage of liver fibrosis critical in order to make antiviral therapeutic decisions for HBV-infected patients. Liver biopsy remains the "gold standard" for diagnosing liver f...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Zeng DW, Dong J, Liu YR, Jiang JJ, Zhu YY Tags: World J Gastroenterol Source Type: research

Microbiota-based treatments in alcoholic liver disease.
Abstract Gut microbiota plays a key role in the pathogenesis of alcoholic liver disease (ALD). Consumption of alcohol leads to increased gut permeability, small intestinal bacterial overgrowth, and enteric dysbiosis. These factors contribute to the increased translocation of microbial products to the liver via the portal tract. Subsequently, bacterial endotoxins such as lipopolysaccharide, in association with the Toll-like receptor 4 signaling pathway, induce a gamut of damaging immune responses in the hepatic milieu. Because of the close association between deleterious inflammation and ALD-induced microbiota imba...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Sung H, Kim SW, Hong M, Suk KT Tags: World J Gastroenterol Source Type: research

Evaluation of preoperative staging for esophageal squamous cell carcinoma.
Abstract Esophageal squamous cell carcinoma (ESCC) is known for its rapid progression and poor outcomes. China has the highest incidence and mortality in the world. Diagnoses made at early stages and accurate staging are associated with better outcomes, all of which can play a significant role in the selection of treatment protocols. ESCC is staged according to the widely accepted TNM system. Common imaging modalities used in staging ESCC before treatment include endoscopy, computed tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). Endoscopic ultrasound is useful for staging...
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Luo LN, He LJ, Gao XY, Huang XX, Shan HB, Luo GY, Li Y, Lin SY, Wang GB, Zhang R, Xu GL, Li JJ Tags: World J Gastroenterol Source Type: research

Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent.
CONCLUSION: This study proves the potential use of hypericin for differential fluorescent detection of human gallstones regarding their chemical composition. PMID: 27547012 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Miranda Cona M, Liu YW, Hubert A, Yin T, Feng YB, de Witte P, Waelkens E, Jiang YS, Zhang J, Mulier S, Xia Q, Huang G, Oyen R, Ni YC Tags: World J Gastroenterol Source Type: research

Alterations in gut microbiota during remission and recurrence of diabetes after duodenal-jejunal bypass in rats.
CONCLUSION: Alterations in gut microbiota may be responsible for the diabetes remission and recurrence after DJB, possibly by influencing serum LPS and TBAs. PMID: 27547013 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Zhong MW, Liu SZ, Zhang GY, Zhang X, Liu T, Hu SY Tags: World J Gastroenterol Source Type: research

Hepatitis C virus G1b infection decreases the number of small low-density lipoprotein particles.
CONCLUSION: HCV G1b infection decreases the numbers of medium, small, and very small LDL particles. PMID: 27547014 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Kinoshita C, Nagano T, Seki N, Tomita Y, Sugita T, Aida Y, Itagaki M, Satoh K, Sutoh S, Abe H, Tsubota A, Aizawa Y Tags: World J Gastroenterol Source Type: research

Smaller tumor size is associated with poor survival in T4b colon cancer.
CONCLUSION: Smaller tumor size is associated with poorer CSS in the T4bN0-2M0 subset of colon cancer, particularly in the T4bN0M0 subgroup. PMID: 27547015 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Huang B, Feng Y, Mo SB, Cai SJ, Huang LY Tags: World J Gastroenterol Source Type: research

Feasibility study on expanded indication for endoscopic submucosal dissection of intramucosal poorly differentiated early gastric cancer.
CONCLUSION: Tumor size, lymphatic vessel involvement and signet-ring-cell component are independently associated with the presence of LNM in intramucosal poorly differentiated EGC. Thus, these three risk factors may be used as a simple criterion to expand the possibility of using ESD for the treatment of intramucosal poorly differentiated EGC. PMID: 27547016 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Li H, Huo ZB, Chen SB, Li H, Wu DC, Zhai TS, Xiao QH, Wang SX, Zhang LL Tags: World J Gastroenterol Source Type: research

Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review.
CONCLUSION: Polymorphisms and genetic factors of several genes contribute to NAFLD and its end results. These genes hold keys to future improvements in diagnosis and management. PMID: 27547017 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2016 Category: Gastroenterology Authors: Severson TJ, Besur S, Bonkovsky HL Tags: World J Gastroenterol Source Type: research

Symbiotic chemo- and immuno-therapy for hepatitis B and C viruses.
Abstract Hepatitis B and C viruses (HBV and HCV), both cause serious chronic infections leading to fatal liver diseases. The prototype therapy for both HBV and HCV was based on IFN-α with or without ribavirin. The advent of direct-acting antivirals (DAA) for both HBV and HCV has remarkably improved the standard of treatment for both infections. While HCV can be eliminated following combination DAA therapy, HBV persists even after treatment, requiring life-long therapy with DAAs. Treatment with DAAs is also associated with high cost, the development of resistance and side effects. There is ample published evidence...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Agrawal B, Kumar R Tags: World J Gastroenterol Source Type: research

Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids.
Abstract Despite recent advances in surgical techniques and perioperative management, the prognosis of pancreatic cancer (PCa) remains extremely poor. To provide optimal treatment for each patient with Pca, superior biomarkers are urgently needed in all phases of management from early detection to staging, treatment monitoring, and prognosis. In the blood of patients with cancer, circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs), such as DNA, mRNA, and noncoding RNA have been recognized. In the recent years, their presence in the blood has encouraged researchers to investigate their potential use ...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Imamura T, Komatsu S, Ichikawa D, Kawaguchi T, Miyamae M, Okajima W, Ohashi T, Arita T, Konishi H, Shiozaki A, Morimura R, Ikoma H, Okamoto K, Otsuji E Tags: World J Gastroenterol Source Type: research

Light and sound - emerging imaging techniques for inflammatory bowel disease.
Abstract Patients with inflammatory bowel disease are known to have a high demand of recurrent evaluation for therapy and disease activity. Further, the risk of developing cancer during the disease progression is increasing from year to year. New, mostly non-radiant, quick to perform and quantitative methods are challenging, conventional endoscopy with biopsy as gold standard. Especially, new physical imaging approaches utilizing light and sound waves have facilitated the development of advanced functional and molecular modalities. Besides these advantages they hold the promise to predict personalized therapeutic ...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Knieling F, Waldner MJ Tags: World J Gastroenterol Source Type: research

Oral pathology in inflammatory bowel disease.
Abstract The incidence of inflammatory bowel diseases (IBD) - Crohn's disease (CD) and ulcerative colitis (UC) - has been increasing on a global scale, and progressively, more gastroenterologists will be included in the diagnosis and treatment of IBD. Although IBD primarily affects the intestinal tract, extraintestinal manifestations of the disease are often apparent, including in the oral cavity, especially in CD. Specific oral manifestations in patients with CD are as follows: indurate mucosal tags, cobblestoning and mucogingivitis, deep linear ulcerations and lip swelling with vertical fissures. The most common...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Muhvić-Urek M, Tomac-Stojmenović M, Mijandrušić-Sinčić B Tags: World J Gastroenterol Source Type: research

Genomic diversity of colorectal cancer: Changing landscape and emerging targets.
Abstract Improvements in screening and preventive measures have led to an increased detection of early stage colorectal cancers (CRC) where patients undergo treatment with a curative intent. Despite these efforts, a high proportion of patients are diagnosed with advanced stage disease that is associated with poor outcomes, as CRC remains one of the leading causes of cancer-related deaths in the world. The development of next generation sequencing and collaborative multi-institutional efforts to characterize the cancer genome has afforded us with a comprehensive assessment of the genomic makeup present in CRC. This...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Ahn DH, Ciombor KK, Mikhail S, Bekaii-Saab T Tags: World J Gastroenterol Source Type: research

New trends in molecular and cellular biomarker discovery for colorectal cancer.
Abstract Colorectal cancer (CRC) is the third leading cause of cancer death worldwide, which is consequence of multistep tumorigenesis of several genetic and epigenetic events. Since CRC is mostly asymptomatic until it progresses to advanced stages, the early detection using effective screening approaches, selection of appropriate therapeutic strategies and efficient follow-up programs are essential to reduce CRC mortalities. Biomarker discovery for CRC based on the personalized genotype and clinical information could facilitate the classification of patients with certain types and stages of cancer to tailor preve...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Aghagolzadeh P, Radpour R Tags: World J Gastroenterol Source Type: research

Laparoscopic and robot-assisted gastrectomy for gastric cancer: Current considerations.
Abstract Radical gastrectomy with an adequate lymphadenectomy is the main procedure which makes it possible to cure patients with resectable gastric cancer (GC). A number of randomized controlled trials and meta-analysis provide phase III evidence that laparoscopic gastrectomy is technically safe and that it yields better short-term outcomes than conventional open gastrectomy for early-stage GC. While laparoscopic gastrectomy has become standard therapy for early-stage GC, especially in Asian countries such as Japan and South Korea, the use of minimally invasive techniques is still controversial for the treatment ...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Caruso S, Patriti A, Roviello F, De Franco L, Franceschini F, Coratti A, Ceccarelli G Tags: World J Gastroenterol Source Type: research

Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis.
Abstract Anastomotic leakage (AL) is one of the most devastating complications after rectal cancer surgery. The double stapling technique has greatly facilitated intestinal reconstruction especially for anastomosis after low anterior resection (LAR). Risk factor analyses for AL after open LAR have been widely reported. However, a few studies have analyzed the risk factors for AL after laparoscopic LAR. Laparoscopic rectal surgery provides an excellent operative field in a narrow pelvic space, and enables total mesorectal excision surgery and preservation of the autonomic nervous system with greater precision. Howe...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Kawada K, Sakai Y Tags: World J Gastroenterol Source Type: research

Hepatopulmonary syndrome: What we know and what we would like to know.
Abstract Hepatopulmonary syndrome (HPS) is characterized by abnormalities in blood oxygenation caused by the presence of intrapulmonary vascular dilations (IPVD) in the context of liver disease, generally at a cirrhotic stage. Knowledge about the subject is still only partial. The majority of the information about the etiopathogenesis of HPS has been obtained through experiments on animals. Reported prevalence in patients who are candidates for a liver transplantation (LT) varies between 4% and 32%, with a predominance of mild or moderate cases. Although it is generally asymptomatic it does have an impact on their...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Grilo-Bensusan I, Pascasio-Acevedo JM Tags: World J Gastroenterol Source Type: research

Gut dysfunction in Parkinson's disease.
Abstract Early involvement of gut is observed in Parkinson's disease (PD) and symptoms such as constipation may precede motor symptoms. α-Synuclein pathology is extensively evident in the gut and appears to follow a rostrocaudal gradient. The gut may act as the starting point of PD pathology with spread toward the central nervous system. This spread of the synuclein pathology raises the possibility of prion-like propagation in PD pathogenesis. Recently, the role of gut microbiota in PD pathogenesis has received attention and some phenotypic correlation has also been shown. The extensive involvement of the gut in ...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Mukherjee A, Biswas A, Das SK Tags: World J Gastroenterol Source Type: research

Acetic acid chromoendoscopy: Improving neoplasia detection in Barrett's esophagus.
Abstract Barrett's esophagus (BE) is an important condition given its significant premalignant potential and dismal five-year survival outcomes of advanced esophageal adenocarcinoma. It is therefore suggested that patients with a diagnosis of BE undergo regular surveillance in order to pick up dysplasia at an earlier stage to improve survival. Current "gold-standard" surveillance protocols suggest targeted biopsy of visible lesions followed by four quadrant random biopsies every 2 cm. However, this method of Barrett's surveillance is fraught with poor endoscopist compliance as the procedures are time consuming and...
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Chedgy FJ, Subramaniam S, Kandiah K, Thayalasekaran S, Bhandari P Tags: World J Gastroenterol Source Type: research

Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats.
CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying. PMID: 27433089 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Matos JF, Americo MF, Sinzato YK, Volpato GT, Corá LA, Calabresi MF, Oliveira RB, Damasceno DC, Miranda JR Tags: World J Gastroenterol Source Type: research

Urotensin II-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in HepG2 cells.
CONCLUSION: UII induces insulin resistance, and this can be reversed by JNK inhibitor SP600125 and antioxidant/NADPH oxidase inhibitor apocynin targeting the insulin signaling pathway in HepG2 cells. PMID: 27433090 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Li YY, Shi ZM, Yu XY, Feng P, Wang XJ Tags: World J Gastroenterol Source Type: research

Nationwide trends and predictors of inpatient mortality in 83884 transjugular intrahepatic portosystemic shunt.
CONCLUSION: The overall mortality of the TIPS procedure is steadily decreasing, though the length of stay has remained relatively constant. Specific patient ethnicity, location, transfer status, primary diagnosis and comorbidities correlate with increased odds of TIPS in-hospital death. PMID: 27433091 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Lee EW, Kuei A, Saab S, Busuttil RW, Durazo F, Han SH, El-Kabany MM, McWilliams JP, Kee ST Tags: World J Gastroenterol Source Type: research

Clinical analysis of patients with hepatocellular carcinoma recurrence after living-donor liver transplantation.
CONCLUSION: Curative treatment for recurrent HCC after LDLT is the most important factor in survival rates after HCC recurrence and combination treatments of sorafenib and an mTOR inhibitor could have survival benefits in patients with HCC recurrence after LT in the palliative treatment group. PMID: 27433092 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Na GH, Hong TH, You YK, Kim DG Tags: World J Gastroenterol Source Type: research

Acceptance of living liver donation among medical students: A multicenter stratified study from Spain.
CONCLUSION: Spanish medical students have a favorable attitude toward LLD. PMID: 27433093 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Ríos A, López-Navas AI, López-López AI, Gómez FJ, Iriarte J, Herruzo R, Blanco G, Llorca FJ, Asunsolo A, Sánchez-Gallegos P, Gutiérrez PR, Fernández A, de Jesús MT, Martínez-Alarcón L, Lana A, Fuentes L, Hernández JR, Virseda J, Yelamos J, Bon Tags: World J Gastroenterol Source Type: research

Low expression of ARID1A correlates with poor prognosis in intrahepatic cholangiocarcinoma.
CONCLUSION: Low expression of ARID1A is associated with poor prognosis in patients with IHCC, and thus may be a potential prognostic biomarker candidate in IHCC. PMID: 27433094 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Yang SZ, Wang AQ, Du J, Wang JT, Yu WW, Liu Q, Wu YF, Chen SG Tags: World J Gastroenterol Source Type: research

Establishment of a nested-ASP-PCR method to determine the clarithromycin resistance of Helicobacter pylori.
CONCLUSION: The nested-ASP-PCR assay showed higher detection sensitivity than ASP-PCR and drug sensitivity testing, which could be performed to evaluate clarithromycin resistance of H. pylori. PMID: 27433095 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Luo XF, Jiao JH, Zhang WY, Pu HM, Qu BJ, Yang BY, Hou M, Ji MJ Tags: World J Gastroenterol Source Type: research

Hemostatic effect of topical hemocoagulase spray in digestive endoscopy.
CONCLUSION: Topical hemocoagulase spray has a definite hemostatic effect for oozing bleeding in digestive endoscopy, and this method is convenient, safe, and reliable. It is expected to become a new method for endoscopic hemostasis. PMID: 27433096 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Wang T, Wang DN, Liu WT, Zheng ZQ, Chen X, Fang WL, Li S, Liang L, Wang BM Tags: World J Gastroenterol Source Type: research

Towards safe injection practices for prevention of hepatitis C transmission in South Asia: Challenges and progress.
CONCLUSION: Injection use is common in South Asian countries. Multilevel interventions aiming at patients, providers and the healthcare system are needed to reduce injection use and reuse. PMID: 27433097 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Janjua NZ, Butt ZA, Mahmood B, Altaf A Tags: World J Gastroenterol Source Type: research

Gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy in the years 2000.
CONCLUSION: The diagnostic work-up requires a multimodal approach and should be implemented (also by further studies on new biomarkers) for a prompt and individualized therapy. PMID: 27433098 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 7, 2016 Category: Gastroenterology Authors: Castagnola E, Ruberto E, Guarino A Tags: World J Gastroenterol Source Type: research

Need of righteous attitudes towards eradication of hepatitis C virus infection in Latin America.
Abstract Over the last few years, we have expanded our knowledge on numerous facets of the hepatitis C virus (HCV). Beginning with its discovery and viral life cycle, its impact on health, the development of liver disease and currently, effective antiviral treatments. The latter point has become of great interest throughout the developed world, where the possible eradication of HCV through specific strategies to reach all HCV-infected people has been announced. However, this scenario is very different in the countries of Latin America (LA), in which < 2% of infected patients requiring treatment have access to H...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Panduro A, Roman S Tags: World J Gastroenterol Source Type: research

Epidemiology of hepatitis E virus in Iran.
Abstract Iran is known as an endemic country for hepatitis E virus (HEV) infection, while there are variations in the epidemiology of HEV infection throughout the country. The available epidemiological studies in different regions of Iran show HEV seroprevalence of 1.1%-14.2% among general population, 4.5% -14.3% among blood donors, 6.1%-22.8% among injecting drug users, 6.3%-28.3% among hemodialysis patients, 1.6%-11.3% among patients infected with other hepatitis viruses, 27.5% among patients with chronic liver disease, 30.8% among kidney transplant recipient patients, and 10%-16.4% among human immunodeficiency ...
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Taherkhani R, Farshadpour F Tags: World J Gastroenterol Source Type: research

Structural and molecular features of intestinal strictures in rats with Crohn's-like disease.
CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. PMID: 27298558 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Talapka P, Berkó A, Nagy LI, Chandrakumar L, Bagyánszki M, Puskás LG, Fekete É, Bódi N Tags: World J Gastroenterol Source Type: research

Apoptosis induced by a low-carbohydrate and high-protein diet in rat livers.
CONCLUSION: Eight weeks of an experimental diet resulted in cellular and histopathological lesions in rat livers. Apoptosis was our principal finding; elevated plasma transaminases demonstrate hepatic lesions. PMID: 27298559 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Monteiro ME, Xavier AR, Oliveira FL, Filho PJ, Azeredo VB Tags: World J Gastroenterol Source Type: research

Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-II expression on dendritic cells in chronic hepatitis C infection.
CONCLUSION: Underexpressed MHC class-II genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs. PMID: 27298560 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Tomer S, Chawla YK, Duseja A, Arora SK Tags: World J Gastroenterol Source Type: research

miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma.
CONCLUSION: The data obtained in the present study suggests that HBx enhances miR-106b transcription to promote tumor progression in HBV-associated HCC. PMID: 27298561 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Yen CS, Su ZR, Lee YP, Liu IT, Yen CJ Tags: World J Gastroenterol Source Type: research

Chitooligosaccharides promote radiosensitivity in colon cancer line SW480.
CONCLUSION: COS can inhibit the proliferation of SW480 cells and enhance the radiosensitization of SW480 cells, inducing apoptosis and G2/M phase arrest. PMID: 27298562 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Han FS, Yang SJ, Lin MB, Chen YQ, Yang P, Xu JM Tags: World J Gastroenterol Source Type: research

Faecalibacterium prausnitzii supernatant ameliorates dextran sulfate sodium induced colitis by regulating Th17 cell differentiation.
CONCLUSION: F. prausnitzii supernatant exerts protective and therapeutic effects on DSS-induced colitis in mice, probably via inhibition of Th17 differentiation and IL-17A secretion in the plasma and colon mucosa tissues. It can also improve colitis in mice by downregulating IL-6 and prevent colitis by upregulating IL-4. PMID: 27298563 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Huang XL, Zhang X, Fei XY, Chen ZG, Hao YP, Zhang S, Zhang MM, Yu YQ, Yu CG Tags: World J Gastroenterol Source Type: research

Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients.
CONCLUSION: The dysbiosis MS rat model and the post-inflammatory rat model captured some of the dysbiosis features of IBS patients. Fusobacterium, Clostridium XI and Porphyromonadaceae were identified as targets for future mechanistic research. PMID: 27298564 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zhou XY, Li M, Li X, Long X, Zuo XL, Hou XH, Cong YZ, Li YQ Tags: World J Gastroenterol Source Type: research

Factors affecting occurrence of gastric varioliform lesions: A case-control study.
CONCLUSION: Seven risk factors and two protective factors are determined for GVLs, which were found to be associated with premalignant abnormalities. PMID: 27298565 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Zou TH, Zheng RH, Gao QY, Kong X, Chen XY, Ge ZZ, Chen YX, Zou XP, Fang JY Tags: World J Gastroenterol Source Type: research

Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study.
CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. PMID: 27298566 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2016 Category: Gastroenterology Authors: Atsushi I, Mitsuyoshi O, Kazuya Y, Syuhei K, Noriyuki K, Masashi M, Akira W, Kentaro S, Nobuyuki K, Natsuko S, Jun W, Yasushi I, Chikara K, Itaru E Tags: World J Gastroenterol Source Type: research