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Development of Magnetic Resonance Based Functional Imaging Techniques Heading Up to Theranostics ~Creating Next Generation Functional Contrast Agents~.
PMID: 27477719 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Takeshita K, Matsumoto K Tags: Yakugaku Zasshi Source Type: research

Development of Magnetic Resonance-based Functional Imaging: The Past, the Present, and the Future.
Abstract The term "theranostics" is a compound word combining "therapeutics" and "diagnostics". Discovery of the X-ray made an extraordinary contribution to the field of medical science. Development of computer science after World War II has been absolutely imperative for the development of medical imaging technology to date. The invention of X-ray computed tomography (CT) has revolutionized medical image diagnostic systems. Several functional imaging modalities emerged not only in the radiological field but also in magnetic resonance and ultrasonic fields. The fusion of three digital imaging techniques, MR Redox ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Matsumoto K Tags: Yakugaku Zasshi Source Type: research

Evaluation of Brain Redox Status and Its Association with Cognitive Dysfunction in Diabetic Animal Models by Redox Molecular Imaging (ReMI).
Abstract Oxidative stress contributes to the development of diabetic complications. Increasing epidemiologic evidence suggests that diabetes mellitus is associated with dementia and cognitive decline. However, the underlying mechanisms are not fully understood. We have evaluated brain redox status and its association of cognitive dysfunction in diabetic animal models by dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) and other oxidative stress markers. In this review, we discuss the role of oxidative stress in the development of diabetes-related dementia and clinical regulation of the redox state...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Sonoda N, Inoguchi T, Minami Y, Hyodo F, Ichikawa K, Yamato M, Utsumi H, Takayanagi R Tags: Yakugaku Zasshi Source Type: research

Nano-theranostics and Nitroxyl Radical-labeled Antitumor Agents for Magnetic Resonance Imaging.
Abstract The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDS) is opening new pathways to understanding pathophysiology using magnetic resonance imaging (MRI). Nitroxyl radical compounds are promising functional contrast agents for redox evaluation. We have developed a novel nitroxyl radical theranostic compound for noninvasive real-time imaging of blood-brain barrier-permeable antitumor drugs. Divalent manganese ions (Mn(2+)) can also be used as an intracellular functional MRI contrast agent. Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activa...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Aoki I Tags: Yakugaku Zasshi Source Type: research

Development of a Functional Contrast Agent for Targeting Lipid-derived Radicals.
Abstract Lipid derived radicals and their metabolic products are closely involved in the pathogenesis of oxidative stress diseases, such as inflammation and angiogenesis, through the formation of a protein or DNA complex. The starting point of lipid peroxide generation is lipid-derived radicals, which increase explosively via radical chain reaction. Therefore, the trapping of lipid-derived radicals is useful in understanding the mechanism of the formation of oxidative stress diseases, and in suppressing the following chain reaction. On the other hand, nitroxides with a stable unpaired electron allow for spin trapp...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Yamada K Tags: Yakugaku Zasshi Source Type: research

Prediction of Cancer Treatment Response by Physiologic and Metabolic Imaging.
Abstract Tumors develop a characteristic microenvironment depending on their specific genetic mutations. The direct products of mutant genes and the resulting microenvironmental changes provoke metabolic changes in the tumor. If noninvasive imaging techniques including magnetic resonance imaging (MRI) could be used to detect such microenvironmental and metabolic changes in tumors, we might be able to provide more effective treatment strategies for individual tumors in patients. In addition to conventional imaging techniques, this review article introduces quantitative 3D oxygen imaging using electron paramagnetic ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Matsumoto S Tags: Yakugaku Zasshi Source Type: research

Development of Redox Metabolic Imaging Using Endogenous Molecules.
We present a spectroscopic imaging technology with DNP-MRI, which enables the imaging of multiple free radical intermediates such as FADH and CoQH. DNP-MRI can also identify various endogenous free radical intermediates derived from redox transformations. PMID: 27477725 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Hyodo F, Ito S, Eto H, Nakaji T, Yasukawa K, Kobayashi R, Utsumi H Tags: Yakugaku Zasshi Source Type: research

Collaborative Approach to Heart Failure Care.
PMID: 27477726 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Takano H, Sato Y Tags: Yakugaku Zasshi Source Type: research

Team Medicine for CHF Treatment.
Abstract The mortality associated with end stage heart failure (HF) is high, despite the development of new and increasingly effective drugs and non-pharmacological therapies. Repetitive hospitalizations predict fatal outcomes, and each hospitalization should prompt individual conversations with the patient, the family and the caregivers. A multidisciplinary disease management program promotes the education of patients and their families, and modifies their behaviour, with a view to ultimately improving the prognosis and quality of life. Beginning with the earliest stages of HF, on through the late stages, a multi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Sato Y Tags: Yakugaku Zasshi Source Type: research

Roles of Cardiology Pharmacists.
Abstract Inpatients with heart failure take a number of high-risk drugs such as anti-thrombotic and anti-arrhythmic drugs, in addition to other drug types, including diuretics and cardioprotective agents. Pharmacists should support the pharmacological management of these patients by evaluating their clinical condition and laboratory data, due to the frequency of renal failure. Furthermore, it is known that poor adherence to a drug regimen is one of the aggravating factors for heart failure. It is necessary to conduct regular patient education to facilitate early hospital discharge and to prevent the recurrence of ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Yamaguchi H Tags: Yakugaku Zasshi Source Type: research

Role of the Pharmacist within the Heart Failure Team.
Abstract Hyogo Prefectural Amagasaki General Medical Center has formed a heart failure team. Here, I report on the role of the pharmacist in this heart failure team at this hospital. Patient education is one of the roles of the pharmacist. It is the pharmacist's responsibility to improve medication adherence among patients. For this purpose, the pharmacist uses a brochure created by the heart failure team. The brochure outlines drug information in an easy-to-understand manner. The roles of a pharmacist were addressed in a lecture presented to the heart failure team. These lectures helped improve the pharmaceutical...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Terasaki N Tags: Yakugaku Zasshi Source Type: research

Roles of Nurses in Home Medical Care.
Abstract Some patients of advanced age with heart failure (HF) require repeated hospital care. In an aging society, the importance of medical and social care support systems for patients with HF further increases. In Onomichi-city, a comprehensive community care system has been in place since its introduction in 1997. The system is called "Onomichi Type". This is an interprofessional care system in which a variety of healthcare professionals, with common basic knowledge of disease prevention, treatment and welfare, collaborate with other care professionals. These professionals gain shared knowledge in regard to ca...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Tomiyama M Tags: Yakugaku Zasshi Source Type: research

Home Medical Care for Heart Failure.
Abstract As heart failure progresses to the end stage, it becomes more difficult to maintain the same level of quality of life using the established therapy for the heart failure patients. We believe that an innovative home medical care for heart failure therapy that focuses on the individual's quality of daily living and early intervention is necessary. The roles of home medical care include: early discharge to home as opposed to long hospitalization; the prevention of re-hospitalization; the provision of good care; treatment of any exacerbations; and options available at the end of the patient's life at home. Be...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Yumino D Tags: Yakugaku Zasshi Source Type: research

Team-based Medical Care for Cardiac Failure-The Pharmacist's Expected Role.
Abstract The pharmacist's role in home care is increasingly important. We are required to collaborate with multiple other professions. As home care pharmaceutical managers, pharmacists verify the timeline of side effects and the onset of expected effects. It is also important to verify all prescriptions from the pharmaceutical viewpoint, and to point out potential negative interactions or consequences of each prescribed medication, suggesting changes or dosage reduction in drugs as appropriate. Additionally, we verify the cause of unused drugs (i.e. patient non-compliance) and take action. As an effort to provide ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Takahashi M Tags: Yakugaku Zasshi Source Type: research

A New Horizon in Vitamin K Research.
Abstract Vitamin K is a cofactor for γ-glutamyl carboxylase, which catalyzes the posttranslational conversion of specific glutamyl residues to γ-carboxyglutamyl residues in a variety of vitamin K-dependent proteins (VKDPs) involved in blood coagulation, bone and cartilage metabolism, signal transduction, and cell proliferation. Despite the great advances in the genetic, structural, and functional studies of VKDPs as well as the enzymes identified as part of the vitamin K cycle which enable it to be repeatedly recycled within the cells, little is known of the identity and roles of key regulators of vitamin K meta...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Okano T Tags: Yakugaku Zasshi Source Type: research

Effects of Food Thickeners on the Inhibitory Effect of Voglibose Oral-disintegrating Tablets on Post-prandial Elevation of Blood Sugar Levels.
Abstract The aim of this study was to examine the effects of food thickeners on the pharmacodynamics of voglibose, an α-glucosidase inhibitor. The pharmacodynamics of voglibose were examined in an open-label study in 9 healthy participants after the ingestion of a single oral dose of a voglibose oral-disintegrating tablet, with and without food thickener immersion. The area under the incremental blood sugar concentration-time curve was larger and the rate of increments in the blood sugar concentration was higher with the voglibose oral-disintegrating tablets immersed in the food thickener than with the tablets th...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Tomita T, Goto H, Sumiya K, Yoshida T, Tanaka K, Kohda Y Tags: Yakugaku Zasshi Source Type: research

Correlations between Plasma Levels of Anionic Uremic Toxins and Clinical Parameters in Hemodialysis Patients.
In this study, we assessed the correlations among plasma levels of indoxyl sulfate (IS), indoleacetic acid (IA), and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) in 20 hemodialysis patients and evaluated the relationship between the plasma levels of UTs and clinical parameters, such as serum creatinine (Scr), blood urea nitrogen, and estimated glomerular filtration rate (eGFR), with special focus on IS. There were no correlations among the plasma levels of the three UTs before and immediately after hemodialysis. However, a significant correlation was observed between plasma IS levels and Scr before hemodialysis...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Ichimura Y, Takamatsu H, Ideuchi H, Oda M, Takeda K, Saitoh H Tags: Yakugaku Zasshi Source Type: research

Clarification of the Relationship between Awareness of Doping of Competitive Sports Coaches and Their Instructions to Prevent Doping.
Abstract It has been 6 years since the establishment of the position of "sports pharmacist" as one type of pharmacist. In the sporting world of Japan, sports pharmacists are expected to promote athletes' awareness of antidoping regulations and provide them with relevant education. However, currently, these pharmacists' main duty is to provide athletes and their coaches with guidance on medication. Using a model for the prediction of athletes' actions, we have worked to promote athletes' awareness of antidoping regulations and encourage sports pharmacists to perform relevant activities, such as antidoping education...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2016 Category: Drugs & Pharmacology Authors: Yamaguchi T, Horio I, Goto M, Miyauchi Y, Izushi F Tags: Yakugaku Zasshi Source Type: research

Survey on disaster relief activities to the pharmacists belonging to Kobe-city pharmaceutical organization.
In this study, pharmacists of a pharmaceutical organization in Kobe City were asked to reply to a questionnaire survey so that their hopes and ideas about the disaster relief activities that they carry out can help build effective educational programs to enhance relief activities. Finally, 8 factors (cumulative contribution rate: 90.9%) were extracted by factor analysis (maximum likelihood method, the diagonal elements: squared multiple correlation, quartimin rotation) of the 25 questions. In addition, a hierarchical cluster analysis (Ward method) by the factor scores of the extracted 8 factors resulted in 7 groups.   Th...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 22, 2016 Category: Drugs & Pharmacology Authors: Yasuhara T, Kondo H, Nagata M, Iwata K, Kushihata T, Katsuragi S, Ikeuchi J, Sone T Tags: Yakugaku Zasshi Source Type: research

Nonprescription Drugs and Self-medication-Approach and Practice to Pharmaceutical Education.
PMID: 27374952 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Watanabe K, Ohno N Tags: Yakugaku Zasshi Source Type: research

Non-prescription Drugs and Self-medication: Features and Subjects in Pharmaceutical Education.
Abstract At the time of consultation with a patient regarding OTC drugs, a pharmacist goes through the following five steps. In Step 1 information is collected, including the patient's gender, age, health condition, living situation, etc. In Step 2, upon analyzing and evaluating this collected information, the pharmacist decides whether to recommend that the patient see a medical doctor or whether an OTC drug is sufficient. In Step 3, when an OTC drug is required, the pharmacist suggests the most suitable OTC drug. In Step 4, the pharmacist provides the patient recommendations and information about the selected OT...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Watanabe K Tags: Yakugaku Zasshi Source Type: research

Primary Care Requirements for Pharmacists-Clinical Reasoning Education at Schools of Pharmaceutical Sciences.
Abstract For appropriate primary care practice corresponding to the various symptoms of a patient, team medicine on that combines the expertise of physicians and other medical staff has been recommended in recent years. It results in (1) higher quality of medical care, (2) lower burden on the physician, (3) better medical safety, and (4) reduced medical expenses. In order to promote team medicine through inter-professional collaboration, the responsibilities of the medical staff need to be reviewed to expand their respective roles. The Ministry of Health, Labour and Welfare designated nine specific medical acts by...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Ashizawa T Tags: Yakugaku Zasshi Source Type: research

Systematic Education of Self-Medication at Tokyo University of Pharmacy and Life Sciences.
Abstract The promotion of self-medication by pharmacies, with the aim of encouraging a patient's self-selection of proper OTC drug, is written about in the national action plan "Japan is Back". The subject of self-medication has been improved in the 2013 revised edition of "Model Core Curriculum for Pharmaceutical Education". At Tokyo University of Pharmacy and Life Sciences, the systematic education of self-medication was started from the onset of the six-year course in the third, fourth and fifth grade. We introduce here a new approach in our systematic education of self-medication. In the practice of the fourth...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Narui K, Samizo K, Inoue M, Watanabe K Tags: Yakugaku Zasshi Source Type: research

Self-medication Activities in a Community Pharmacy for Student Pharmacist Training.
Abstract Japan's Ministry of Health, Labour and Welfare published "the required function and the desired operating form of a pharmacy" and proposed that "a pharmacy should demonstrate a positive role for the promotion of self-medication". In the future, it will be indispensable to pharmacies that pharmacists play a role not only in dispensing medicine but also in serving a central health-station role in the community, including promoting the self-selection of proper OTC medications for the maintenance of health. My pharmacy in a traditional area in Tokyo carries OTC drugs, health and nursing care goods, medical su...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Sakaguchi M Tags: Yakugaku Zasshi Source Type: research

Issues and Prospects from the OTC Industry vis a vis Pharmaceutical Education and OTC Medicines.
Abstract In the amendment of the Pharmaceutical Affairs Law in 2013, a new category, Pharmacist Intervention Required Medicines (PIRM), was introduced, and other OTC medicines, which were classified after the 2006 amendment, were allowed to be sold via the Internet. Regarding PIRM, Japan's Ministry for Health, Labour and Welfare designates medicines which require special intervention by a pharmacist who explains their proper use to a patient through a face-to-face consultation, wherein the pharmacist provides guidance based on pharmaceutical knowledge and experience. This encourages consumers to approach their lon...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Nishizawa M Tags: Yakugaku Zasshi Source Type: research

Possibility of Pharmacist in Emergency Medical Care: To Bring Up a Familiar Pharmacist for Emergency Care by Fusing Clinical Pharmacist Activity and University Education.
PMID: 27374958 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Zamami Y, Koyama T, Nakura H, Enomoto S Tags: Yakugaku Zasshi Source Type: research

Involvement of Pharmacists in Medical Care in Emergency and Critical Care Centers.
Abstract Emergency and critical care centers provide multidisciplinary therapy for critically ill patients by centralizing the expertise and technology of many medical professionals. Because the patients' conditions vary, different drug treatments are administered along with surgery. Therefore, the role of pharmacists is important. Critically ill patients who receive high-level invasive treatment undergo physiological changes differing from their normal condition along with variable therapeutic effects and pharmacokinetics. Pharmacists are responsible for recommending the appropriate drug therapy using their knowl...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Imai T, Yoshida Y Tags: Yakugaku Zasshi Source Type: research

Participation of Pharmacists in Emergency Care at Outpatient Clinics with Multiple Beds.
Abstract A major difference in medical flow between acute and nonacute medical care is the urgency of diagnosis and treatment. In the acute medical setting, diagnosis and treatment sometimes must be done almost simultaneously. Learning clinical management in the acute-care setting can be the basis of drug therapy in other clinical settings. When infusion is performed in emergency medicine, stabilization of blood pH is achieved through kidney and lung functions. At the same time, the oxygen transport capacity is monitored using blood gas analysis. One medical intervention can lead to multiple diagnostic and treatme...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Deguchi H Tags: Yakugaku Zasshi Source Type: research

Physical Assessment Education Using Various Simulators.
Abstract Pharmacists are in demand not only because of their knowledge of medical therapy but also due to their skills in basic physical assessment and emergency care as medical personnel. Pharmaceutical education has developed using patient simulators in bedside training, seminars in hospital pharmacies, and physical assessment practice at the Kyushu University of Health and Welfare School of Pharmaceutical Sciences. We first explain the outline of the method to confirm basic vital signs with simulators and then demonstrate some simulations to enable the reproduction of drug misadministration/changes in condition...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Tokunaga J, Takamura N, Ogata K, Setoguchi N, Sato K Tags: Yakugaku Zasshi Source Type: research

Pharmaceutical Education Focused on Pharmacotherapy in Emergency Medical Care.
Abstract Pharmacists are expected to be active members of the healthcare team in emergency medicine, because many pharmaceuticals are administered to patients with life-threatening conditions. However, adequate education for pharmacists and pharmacy students is not provided. The "Emergency Pharmaceutical Sciences" course was introduced for the first time in Japan by the Department of Pharmacy, Okayama University, to offer advanced education in emergency medicine and research related to critical care. We offer an emergency pharmaceutical training program with high-performance simulators and have succeeded in improv...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Zamami Y, Koyama T, Imai T, Takemoto A, Sagara H, Sendo T, Nakura H Tags: Yakugaku Zasshi Source Type: research

Social Pharmacy: Its Performance and Promise.
Abstract Among private Universities of Pharmacy in Japan, Kyoritsu University of Pharmacy was the first to introduce courses in social pharmacy in 1991. Social pharmacy is a discipline driven by social needs. By studying the relationship between pharmacy and society, particularly through case studies, the impact of drugs and changes in societal expectation of them, as well as through historical background studies and surveys of current trends, this discipline acts to determine the roles of pharmacists and pharmacies expected by society. Social pharmacy requires a basic knowledge of pharmaceutical science, but an u...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Fukushima N Tags: Yakugaku Zasshi Source Type: research

Changes in Legal Aspects of Public Education about Drugs and Their Importance.
Abstract Requirements for education on proper use of drugs were included in the junior high school educational guideline in 2012 incorporating pharmaceutical education in the obligatory school curriculum. This move is closely related to the country's new OTC drug marketing system. The amendment of the Pharmaceutical Affairs Law (PAL) in 2013 highlighted the public's own role in "promoting proper use of drugs and other related products and making greater efforts to acquire knowledge and improve understanding of their effective and safe use". Furthermore, the Law to Amend the PAL and Pharmacists Law enforced in 2014...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Miyamoto N Tags: Yakugaku Zasshi Source Type: research

Molecular Mechanisms of Taste Disorder in Oxaliplatin-administered Rats.
In conclusion, the decreased response to sweet taste by oxaliplatin administration may be due to the upregulation of T1R2 expression. PMID: 27374965 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Nishida K Tags: Yakugaku Zasshi Source Type: research

Protective Efficacy of the Ingestion of Mandarin Orange Containing β-Cryptoxanthin on Lipopolysaccharide-induced Acute Nephritis.
Abstract β-cryptoxanthin is a common carotenoid pigment found in fruit, especially in Satsuma mandarins and in persimmons. After ingestion, β-cryptoxanthin is distributed to and accumulates in organs, such as the liver, lung, and kidney. Recent studies have reported that because of its antioxidant defense, β-cryptoxanthin performs several important functions in the preservation of human health and in the prevention of several diseases, including cancer and osteoporosis. The present study aims to determine whether β-cryptoxanthin has a protective effect on renal glomeruli during acute nephritis. To develop our ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Hikita M, Motojima K, Kamata S, Yoshida T, Tanaka-Nakadate S, Nakadate K Tags: Yakugaku Zasshi Source Type: research

An Attempt to Measure Presentation Skill Acquisition Using Peer and Self-evaluation.
Abstract In six-year pharmacy education programs, humanistic education is now regarded as more important than ever, and we are working to incorporate active learning methods into a variety of subjects. Because performance evaluations are by their nature subjective, it is difficult to ensure the validity of any given assessment. Fifth-year students at Tohoku Pharmaceutical University learn case and prescription analysis in problem-based learning tutorials. As part of this curriculum, 20 presentation and discussion meetings over the course of 10 weeks are held, with approximately 100 students making presentations tw...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Morone M, Sato A, Ohno I, Ohkawara Y, Suzuki T, Nakamura H, Azuma Y Tags: Yakugaku Zasshi Source Type: research

Interdisciplinary Subject "Yakugaku Nyumon" for First-year Students Constructed with Lectures and Problem-based Learning.
Abstract In 2013, Kobe Pharmaceutical University established "Yakugaku Nyumon", an interdisciplinary course, which consists of omnibus lectures and problem-based learning (PBL) on topics ranging from basic to clinical subjects. The themes of the PBL were original ones; "Study from package inserts of aspirin", which aimed to reinforce the contents of the interdisciplinary lectures, and "Let's think about aspirin derivatives (super-aspirin)", which aimed to engender an interest in studying pharmacy. The PBL featured questions from teachers to help with study and was therefore referred to as "question-led PBL" (Q-PBL...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Yamaki K, Ueda M, Ueda K, Emoto N, Mizutani N, Ikeda K, Yagi K, Tanaka M, Habu Y, Nakayama Y, Takeda N, Moriwaki K, Kitagawa S Tags: Yakugaku Zasshi Source Type: research

Association between Selective Beta-adrenergic Drugs and Blood Pressure Elevation: Data Mining of the Japanese Adverse Drug Event Report (JADER) Database.
Abstract Selective beta-adrenergic drugs are used clinically to treat various diseases. Because of imperfect receptor selectivity, beta-adrenergic drugs cause some adverse drug events by stimulating other adrenergic receptors. To examine the association between selective beta-adrenergic drugs and blood pressure elevation, we reviewed the Japanese Adverse Drug Event Reports (JADERs) submitted to the Japan Pharmaceuticals and Medical Devices Agency. We used the Medical Dictionary for Regulatory Activities (MedDRA) Preferred Terms extracted from Standardized MedDRA queries for hypertension to identify events related ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2016 Category: Drugs & Pharmacology Authors: Ohyama K, Inoue M Tags: Yakugaku Zasshi Source Type: research

Lifestyle improvement through continuous measurements of hemoglobin A1c levels and lifestyle checks at the community pharmacy in three cases.
In this study, we took continuous measurements of hemoglobin A1c (HbA1c) levels and conducted lifestyle checks in three cases to determine if these parameters were effective in improving overall wellness. We selected three young men with relatively high HbA1c levels. During the 12-weeks study periods, we regularly measured each participant's HbA1c levels and monitored their lifestyle habits every two weeks at the community pharmacy once every 2 weeks using specific guidelines. The first participant, a 23-year-old man, had a HbA1c level of 5.7% at his first measurement. His HbA1c level decreased to 5.2% at the last measurem...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 28, 2016 Category: Drugs & Pharmacology Authors: Fujita N, Nabetani N, Umemura N, Kikuchi C, Suzuki T Tags: Yakugaku Zasshi Source Type: research

Creation new patient information leaflets with diabetes by pharmacists and assesment conducted by patients.
Abstract  We created a draft of new patient information leaflets to ensure patients' proper use of drugs and to highlight safety issues and improvement plans extracted and proposed by small group discussions (SGD) with pharmacists. A total of 3 SGDs (participants: 15 pharmacists) were conducted with the aim of improving patient information leaflets for oral diabetes drugs. First, the disadvantages and advantages of the current instructions as well as requests for ideal patient information leaflets were obtained from participants.Conventional patient information leaflets that could be improved were useful to unde...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 27, 2016 Category: Drugs & Pharmacology Authors: Arai M, Maeda K, Satoh H, Miki A, Sawada Y Tags: Yakugaku Zasshi Source Type: research

Usability of an alcohol disinfectant containing organic acids and metal salt for environmental surfaces.
Abstract   Environmental cleaning and disinfection plays an important role as a part of the standard precautions to prevent healthcare-associated infections, whereas hand hygiene is one of the most important strategies for breaking the chain of transmission. Cleaning and disinfection of high-touch areas in a health-care facility is emphasized. And wiping with an alcohol-saturated cloth which has features such as low corrosion and a wide range of antimicrobial activity is performed commonly for this purpose. Although alcohol provides immediate activity against enveloped viruses, its virucidal activity against cer...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 15, 2016 Category: Drugs & Pharmacology Authors: Okunishi J, Nagahara H, Tsujitani K, Matsuse H, Kugawa K, Soga M Tags: Yakugaku Zasshi Source Type: research

School Pharmacists and Methods of Analysis in Health Science: Pharmaceutical Health Science for the Protection of Children's Health.
PMID: 27252051 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Jinno H, Ueno H Tags: Yakugaku Zasshi Source Type: research

Management for School Environmental Health in Japan.
Abstract Some acts such as the Basic Environment Act are aimed at managing environmental health for a productive living environment in Japan. School is not only a place where lessons for a better future are taught but also an environment in which children spend many hours of their day. Therefore, activities involving regular checks are important to maintain and improve the school environment. Article 5 of the School Health and Safety Act states that schools must make plans and carry out regular checks on school environmental health. Article 6 prescribes that the Minister of Education, Culture, Sports, Science and ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Kitagaki K Tags: Yakugaku Zasshi Source Type: research

School Pharmacist/School Environmental Hygienic Activities at School Site.
Abstract The "School Health and Safety Act" was enforced in April 2009 in Japan, and "school environmental health standards" were established by the Minister of Education, Culture, Sports, Science and Technology. In Article 24 of the Enforcement Regulations, the duties of the school pharmacist have been clarified; school pharmacists have charged with promoting health activities in schools and carrying out complete and regular checks based on the "school environmental health standards" in order to protect the health of students and staff. In supported of this, the school pharmacist group of Japan Pharmaceutical Ass...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Muramatsu A Tags: Yakugaku Zasshi Source Type: research

School Pharmacist and "Methods of Analysis in Health Science".
The objectives of the "environmental" component of the pharmacy education model core curriculum include performing analyses corresponding to the regularly checked items of the school environmental health standards. Students of the School of Pharmacy should cultivate their expertise in environmental analysis and environmental health, through practices such as sample collection, analysis operation, and evaluation of test results. As analysis experts, school pharmacists must know the principles and characteristics of analytical methods. The "Methods of Analysis in Health Science" published by the Pharmaceutical Society of Jap...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Nagase H Tags: Yakugaku Zasshi Source Type: research

Current Indoor Air Quality in Japan.
Abstract People spend more than two thirds of their daily time indoors. Hence, maintaining a healthy indoor environment is indispensable for the prevention of building related illness. In Japan, guidelines for indoor air quality have been established for 13 volatile/semi-volatile organic compounds (VOCs/SVOCs). These guidelines are now under revision by the Committee on Sick House Syndrome: Indoor Air Pollution. In order to gain information on the current indoor air pollutants and their levels, we carried out a nation-wide survey of VOCs and aldehydes in indoor residential air during 2012-2013. In this review, I c...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Jinno H Tags: Yakugaku Zasshi Source Type: research

Exposure Measurements in Japan Environment and Children's Study.
Abstract The Japan Ministry of the Environment is conducting a large-scale birth cohort study called the Japan Environment and Children's Study (JECS), which involves 100000 mother-child pairs. Mothers are enrolled during pregnancy, and their children are followed up and studied until they reach the age of 13 years. The JECS started recruiting mothers in January 2011 and completed the registration of more than 103000 mothers in March 2014. The National Institute for Environmental Studies takes the lead in the study programming and implementation in cooperation with the National Centre for Child Health and Developm...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Nakayama S Tags: Yakugaku Zasshi Source Type: research

Mechanisms and Pharmacological Strategy Targeting Dysfunction of Endoplasmic Reticulum.
PMID: 27252057 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Ozawa K, Nomura Y, Kitamura Y Tags: Yakugaku Zasshi Source Type: research

Regulation of Unfolded Protein Response via Protein S-nitrosylation.
Abstract Nitric oxide (NO) plays a pivotal function in neurotransmission, vasodilation, proliferation, and apoptosis in various types of cells via protein S-nitrosylation. Previously we demonstrated that protein disulfide isomerase (PDI) is S-nitrosylated in brains manifesting sporadic neurodegenerative diseases. This modification results in dysfunction of its enzymatic activity and consequently the accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER). The aim of this study was to clarify the detailed function of NO on unfolded protein response (UPR) branches. We here found that the ER str...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Ohkubo Y, Nakato R, Uehara T Tags: Yakugaku Zasshi Source Type: research

Physiological Roles of Ubiquitin Ligases Related to the Endoplasmic Reticulum.
In conclusion, oxidative stress-induced HRD1 insolubilization might be involved in a vicious cycle of increased Aβ production and Aβ-induced oxidative stress in Alzheimer's disease pathogenesis. PMID: 27252059 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Kaneko M Tags: Yakugaku Zasshi Source Type: research

ER Stress-induced Aberrant Neuronal Maturation and Neurodevelopmental Disorders.
Abstract Neurodevelopmental disorders, which include autism spectrum disorder, are congenital impairments in the growth and development of the central nervous system. They are mainly accentuated during infancy and childhood. Autism spectrum disorder may be caused by environmental factors, genomic imprinting of chromosome 15q11-q13 regions, and gene defects such as those in genes encoding neurexin and neuroligin, which are involved in synaptogenesis and synaptic signaling. However, regardless of the many reports on neurodevelopmental disorders, the pathogenic mechanism and treatment of neurodevelopmental disorders ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Kawada K, Iekumo T, Kaneko M, Nomura Y, Okuma Y Tags: Yakugaku Zasshi Source Type: research