Platinum(IV) compounds as potential drugs: a quantitative structure-activity relationship study
CONCLUSION: Complexes 1, 3 and 13 have high generalized optimality criteria and are predicted as potential SARS-CoV RNA dependent RNA polymerase inhibitors.PMID:37736338 | PMC:PMC10509740 | DOI:10.34172/bi.2023.24180
Source: BioImpacts - September 22, 2023 Category: Research Authors: Jurica Novak Alena R Zykova Vladimir A Potemkin Vladimir V Sharutin Olga K Sharutina Source Type: research

Low-density lipoprotein subclasses over the menopausal transition and risk of coronary calcification and carotid atherosclerosis: the SWAN Heart and HDL ancillary studies
CONCLUSIONS: During the MT, women experience significant increases in LDL subclasses found to be related to greater cIMT levels and CAC prevalence. Whether these changes could better predict future risk of hard cardiovascular disease events beyond LDL-C remains a research question to address.PMID:37738035 | DOI:10.1097/GME.0000000000002245
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Samar R El Khoudary Xirun Chen Ziyuan Wang Maria M Brooks Trevor Orchard Sybil Crawford Imke Janssen Susan A Everson-Rose Daniel McConnell Karen Matthews Source Type: research

Depression, sleep, body image, and lifestyle: Prevalence and associated factors of depression among school-going adolescents in Delhi National Capital Region
CONCLUSIONS: Depression is common among adolescents and shows associations with poor sleep quality and lifestyle choices. Awareness of these associations may enable better screening and early intervention for vulnerable adolescents.PMID:37736230 | PMC:PMC10510640 | DOI:10.4103/indianjpsychiatry.indianjpsychiatry_19_23
Source: Indian Journal of Psychiatry - September 22, 2023 Category: Psychiatry Authors: Tejasvini Khanna Bratati Banerjee Madan M Majhi Dheeman Futela Source Type: research

Relationship of personality, psychological distress, and substance use with social network characteristics of college going young adults
CONCLUSION: Personality and psychological distress are associated with an individual's social network and significantly contribute to student substance use problems.PMID:37736229 | PMC:PMC10510637 | DOI:10.4103/indianjpsychiatry.indianjpsychiatry_182_23
Source: Indian Journal of Psychiatry - September 22, 2023 Category: Psychiatry Authors: P C Pradeep Kumar Sojan Antony Pratima Murthy Ammapattian Thirumoorthy Mariamma Philip Source Type: research

Novel intervention of high-frequency repetitive transcranial magnetic stimulation in patients with somatic symptom disorder and its safety and outcome
Indian J Psychiatry. 2023 Aug;65(8):887-891. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_65_23. Epub 2023 Aug 7.ABSTRACTSomatic Symptom disorders (SSDs) are characterised by the presence of persistent somatic symptoms associated with excessive thoughts, feelings and behaviours related to the symptoms. However, current treatment modalities are non-specific with modest effects. We aim to explore the safety and outcome of high-frequency transcranial magnetic stimulation at medial Prefrontal Cortex in ten such patients. Patient Health Questionnaire-15, Hamilton Rating Scale for Depression and Hamilton Anxiety Rating Scale...
Source: Indian Journal of Psychiatry - September 22, 2023 Category: Psychiatry Authors: Nand Kumar Prakamya Singal Abhishek Chakladar Source Type: research

Libya: 'The Mental Toll is Very High' - Survivors of Floods Grapple With Trauma
[UN News] Post-traumatic stress and anxiety has become a daily challenge for thousands of Libyans who survived Storm Daniel nearly two weeks ago, UN humanitarians warned on Thursday.
Source: AllAfrica News: Health and Medicine - September 22, 2023 Category: African Health Tags: Aid and Assistance External Relations Health and Medicine International Organizations and Africa Libya North Africa Source Type: news

Prevalence and risk factors of disordered eating behavior in youth with hypertension disorders
ConclusionsDEB prevalence is higher in youth with HTN disorders and comparable to other conditions requiring lifestyle counseling. Youth with HTN disorders may benefit from DEB screening.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Increasing the transparency of systematic reviews: presenting a generalized registration form
AbstractThis paper presents a generalized registration form for systematic reviews that can be used when currently available forms are not adequate. The form is designed to be applicable across disciplines (i.e., psychology, economics, law, physics, or any other field) and across review types (i.e., scoping review, review of qualitative studies, meta-analysis, or any other type of review). That means that the reviewed records may include research reports as well as archive documents, case law, books, poems, etc. Items were selected and formulated to optimize broad applicability instead of specificity, forgoing some benefit...
Source: Systematic Reviews - September 22, 2023 Category: International Medicine & Public Health Source Type: research

Speculation on optimal numbers of examined lymph node for early-stage epithelial ovarian cancer from the perspective of stage migration
This study comprehensively considered the stage migration and survival to determine appropriate numbers of examined lymph node (ELN) for early-stage EOC and high-grade serous ovarian cancer (HGSOC).MethodsFrom the Surveillance, Epidemiology, and End Results database, we obtained 10372 EOC cases with stage T1M0 and ELN ≥ 2, including 2849 HGSOC cases. Generalized linear models with multivariable adjustment were used to analyze associations between ELN numbers and lymph node stage migration, survival and positive lymph node (PLN). LOESS regression characterized dynamic trends of above associations followed by Chow test to ...
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review
ConclusionOur case indicates that Janus kinase 2 (JAK2)-related PV is a treatable cause of late-onset chorea and that chorea may herald the deterioration of hematological parameters. Our case provides a clinically specific representation of post-PV MF. Patients with a long course of PV are recommended to undergo bone marrow re-examinations when they present with neuropsychiatric symptoms to achieve an early diagnosis of post-PV MF.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research

“Ready-to-use” two-week home exercise program targeting depressive symptoms: pilot study
Exercise is an evidence-based treatment for depressive symptoms, yet it often requires specialised knowledge, equipment, or professional supervision. Lay people in certain contexts, for example in remote locations or under pandemic restrictions, often lack these resources and thus cannot use exercise to manage their depressive symptoms. We developed a two-week home exercise program that bypasses these barriers and tested it in university students during pandemic restrictions. In an online study, we recruited 49 participants to complete a week of baseline symptom monitoring then follow the exercise program for 2 weeks (6 se...
Source: Frontiers in Psychiatry - September 22, 2023 Category: Psychiatry Source Type: research

School distress and the school attendance crisis: a story dominated by neurodivergence and unmet need
ConclusionWhile not a story of exclusivity relating solely to autism, School Distress is a story dominated by complex neurodivergence and a seemingly systemic failure to meet the needs of these CYP. Given the disproportionate number of disabled CYP impacted, we ask whether the United Kingdom is upholding its responsibility to ensure the “right to an education” for all CYP (Human Rights Act 1998).
Source: Frontiers in Psychiatry - September 22, 2023 Category: Psychiatry Source Type: research

Effect of coercive measures on treatment outcome in involuntarily admitted patients in Amsterdam
ConclusionSeclusion, whether or not in combination with forced medication, was applied to two-fifths of patients. The HoNOS scores of the group without coercion improved by nearly two and a half points more on average than those of the two groups with coercion. A causal relationship between coercion and treatment outcome could neither be confirmed nor excluded on the basis of our results.
Source: Frontiers in Psychiatry - September 22, 2023 Category: Psychiatry Source Type: research

Cardiovascular adverse reactions associated with escitalopram in patients with underlying cardiovascular diseases: a systematic review and meta-analysis
ConclusionEscitalopram does not significantly increase the risk of cardiovascular adverse reactions compared with placebo in patients with underlying cardiovascular disease. However, the presence of wide CIs and the limited number of included studies highlight the need for further studies with larger sample sizes to enhance the precision and reliability of these findings.Systematic review registration: International Prospective Register of Systematic Reviews [CRD42022298181].
Source: Frontiers in Psychiatry - September 22, 2023 Category: Psychiatry Source Type: research

Interoception, alexithymia, and anxiety among individuals with alcohol use disorder
ConclusionThe results suggests that interoceptive impairment contributes to greater negative affect (i.e., state anxiety) via alexithymia especially for individuals with AUD. Improving emotion recognition via therapeutic methods focused on strengthening interoceptive abilities could improve outcomes for individuals receiving treatment for AUD.
Source: Frontiers in Psychiatry - September 22, 2023 Category: Psychiatry Source Type: research

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