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The adjuvant component α-tocopherol triggers via modulation of Nrf2 the expression and turnover of hypocretin in vitro and its implication to the development of narcolepsy.
CONCLUSION: In case of a genetic predisposition (DQB1*602) α-tocopherol could confer to development of narcolepsy by activation of Nrf2 that finally leads to an elevated formation of longer hypocretin-derived fragments that can be presented by HLA-subtype DQB1*602. These cells are recognized by the immune system and due to their increased sensitivity to apoptotic stimuli they can be destroyed, finally leading to a lack of hypocretin.
PMID: 24721530 [PubMed - as supplied by publisher]
Source: Vaccine - April 7, 2014 Category: Allergy & Immunology Authors: Masoudi S, Ploen D, Kunz K, Hildt E Tags: Vaccine Source Type: research
UK study strengthens link between GSK flu shot and narcolepsy
LONDON (Reuters) - Children in Britain who were vaccinated with a GlaxoSmithKline shot against H1N1 swine flu had a significantly increased risk of developing the rare sleep disorder narcolepsy, according to results of a scientific study.
Source: Reuters: Health - January 31, 2013 Category: Consumer Health News Tags: healthNews Source Type: news
HPA warns of link between narcolepsy and swine flu vaccine
Researchers have discovered that there may be a link between children developing narcolepsy and the Pandemrix flu vaccine.
Source: Nursing Times Breaking News - February 27, 2013 Category: Nursing Source Type: news
On the Flu Vax?Narcolepsy Link
Researchers identify a peptide present in the swine-flu vaccine linked to narcolepsy that may be responsible for the sleep disorder.
Source: The Scientist - July 1, 2015 Category: Science Tags: Daily News Source Type: news
Did the 2009 flu vaccine give some people narcolepsy?
Following the 2009 H1N1 or swine flu pandemic, scientists saw an increase in narcolepsy cases in countries where an immune system booster was use in shots. Now, the US stockpiles it.
Source: the Mail online | Health - July 5, 2018 Category: Consumer Health News Source Type: news
Flu research may lead to universal vaccine
Conclusion
This research has identified that CD8+ T-cells are linked with protection against different strains of influenza. They are also linked with reduced severity of flu.
The authors note that current vaccines that use inactivated forms of the flu virus protect against specific strains, and do not induce a strong maintained T-cell response. They suggest that, in light of their findings, this may be the reason why they produce limited protection across different subtypes of influenza virus. They say that further testing is needed to see if the live vaccines being used are better at producing cross-subtype protection, ...
Source: NHS News Feed - September 23, 2013 Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news
Swine flu jab linked to sleep disorder: Fears one million children received jab that can increase risk of narcolepsy
New research shows the Pandemrix vaccine carries a 14-fold extra risk of triggering narcolepsy, in which sufferers can fall asleep suddenly and unexpectedly (posed by model).
Source: the Mail online | Health - February 27, 2013 Category: Consumer Health News Source Type: news
Influenza vaccine linked to narcolepsy in children in England
Researchers have found an increased risk for narcolepsy in children who received the swine flu vaccination in England.
Source: MedWire News - Infectious Diseases - March 1, 2013 Category: Infectious Diseases Source Type: news
Predicting hotspots for future flu outbreaks
This year's unusually long and rocky flu season would be nothing compared to the pandemic that could occur if bird flu became highly contagious among humans, which is why UCLA researchers and their colleagues are creating new ways to predict where an outbreak could emerge.
"Using surveillance of influenza cases in humans and birds, we've come up with a technique to predict sites where these viruses could mix and generate a future pandemic," said lead author Trevon Fuller, a UCLA postdoctoral research fellow at the Institute of the Environment and Sustainability's Center for Tropical Research.
The researchers'...
Source: UCLA Newsroom: Health Sciences - March 14, 2013 Category: Universities & Medical Training Source Type: news
Boy, 7, who developed narcolepsy after swine flu jab is denied compensation because he is 'not ill enough' - even though he sleeps 19 hours a day
Josh Hadfield, from Somerset, takes a cocktail of drugs to control his narcolepsy as otherwise he falls asleep up to every five minutes - even while walking and eating.
Source: the Mail online | Health - September 25, 2013 Category: Consumer Health News Source Type: news
Journal Retracts Paper Linking "Swine Flu" Vaccine and Narcolepsy
The retraction represents a setback for those trying to explain a puzzling cluster of sudden-onset narcolepsy reported in 2010 in Europe
-- Read more on ScientificAmerican.com
Source: Scientific American - Official RSS Feed - August 1, 2014 Category: Science Tags: Health Infectious Diseases Pharmaceuticals Source Type: research
Josh Hadfield who developed narcolepsy after H1N1 swine flu jab awarded £120k
Josh Hadfield, from Somerset, developed narcolepsy after the Pandremix vaccine 6 years ago. The vaccine is associated with a 14-fold increase in a child's risk of developing the condition.
Source: the Mail online | Health - February 3, 2016 Category: Consumer Health News Source Type: news
Frog slime could protect us against future flu epidemic
Conclusion
This study has identified a substance in the mucus secreted by a south Indian frog which can kill certain types of flu virus.
Researchers often turn to natural substances with known health-giving properties to find potential new drugs for humans. For example, aspirin was developed based on a compound found in willow bark – which had been used in traditional medicine for hundreds of years.
Some other drugs – such as some chemotherapy and anticlotting drugs – have also been developed from chemicals found in plants.
By isolating the substances that have an effect the researchers can make sure they are pure a...
Source: NHS News Feed - April 19, 2017 Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news
Quality of life and trust among young people with narcolepsy and their families, after the Pandemrix ® vaccination: protocol for a case-control study
The extensive vaccination programme against swine flu resulted in an increased incidence of narcolepsy among children and adolescents. There is a need to explore if these young persons ’ experiences have affect...
Source: BMC Pediatrics - August 23, 2017 Category: Pediatrics Authors: Karin Blomberg, Agneta Anderz én Carlsson, Lars Hagberg, Östen Jonsson, Lena Leissner and Mats H. Eriksson Tags: Study protocol Source Type: research
